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Aliases for PROCA1 Gene

Aliases for PROCA1 Gene

  • Protein Interacting With Cyclin A1 2 3 4 5
  • Proline-Rich Cyclin A1-Interacting Protein 2

External Ids for PROCA1 Gene

Previous GeneCards Identifiers for PROCA1 Gene

  • GC17M024054
  • GC17M027030
  • GC17M023239

Summaries for PROCA1 Gene

GeneCards Summary for PROCA1 Gene

PROCA1 (Protein Interacting With Cyclin A1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G3.

Additional gene information for PROCA1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROCA1 Gene

Genomics for PROCA1 Gene

Regulatory Elements for PROCA1 Gene

Enhancers for PROCA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H028715 1.7 Ensembl ENCODE dbSUPER 22.4 -10.9 -10853 14 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ENSG00000264577 NUFIP2 SUPT6H TMEM199 PROCA1 ENSG00000264647 SARM1 RPL23A PHF12 ANKRD13B
GH17H028863 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -153.3 -153266 3 HDGF ARNT ARID4B ZNF766 CBX5 ZC3H11A JUNB REST SMARCB1 ZNF592 DHRS13 PROCA1 FLOT2 NEK8 TLCD1 SNORD4B SNORD42A RAB34 RPL23A SNORD42B
GH17H028737 1.7 FANTOM5 ENCODE dbSUPER 20.3 -32.1 -32149 13 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A SSRP1 GLIS1 NR2C1 SUPT6H PROCA1 TRAF4 NUFIP2 ENSG00000264577 GC17P028751
GH17H028709 1.1 ENCODE 22.7 +0.6 605 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 SP3 MXD4 PROCA1 ENSG00000264577 SDF2 TMEM199 NUFIP2 SUPT6H RPL23A PHF12 ENSG00000265205
GH17H028643 1.1 ENCODE 22.7 +66.4 66350 4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ENSG00000264577 NUFIP2 SUPT6H LOC101927018 PHF12 ENSG00000265205 PROCA1 ENSG00000265908 TMEM199 PIGS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROCA1 on UCSC Golden Path with GeneCards custom track

Promoters for PROCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092754 771 1801 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 SP3 MXD4 NFYC

Genomic Location for PROCA1 Gene

Chromosome:
17
Start:
28,703,197 bp from pter
End:
28,712,071 bp from pter
Size:
8,875 bases
Orientation:
Minus strand

Genomic View for PROCA1 Gene

Genes around PROCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCA1 Gene

Proteins for PROCA1 Gene

  • Protein details for PROCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ7-PRCA1_HUMAN
    Recommended name:
    Protein PROCA1
    Protein Accession:
    Q8NCQ7
    Secondary Accessions:
    • B4DX95
    • G5E9R8
    • Q6PKN3

    Protein attributes for PROCA1 Gene

    Size:
    364 amino acids
    Molecular mass:
    40522 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAT09159.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAT09159.1; Type=Frameshift; Positions=10, 44; Evidence={ECO:0000305};

    Alternative splice isoforms for PROCA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROCA1 Gene

Post-translational modifications for PROCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PROCA1 Gene

Domains & Families for PROCA1 Gene

Gene Families for PROCA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROCA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PROCA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCQ7

UniProtKB/Swiss-Prot:

PRCA1_HUMAN :
  • Belongs to the PROCA1 family.
Family:
  • Belongs to the PROCA1 family.
genes like me logo Genes that share domains with PROCA1: view

Function for PROCA1 Gene

Phenotypes From GWAS Catalog for PROCA1 Gene

Gene Ontology (GO) - Molecular Function for PROCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with PROCA1: view
genes like me logo Genes that share phenotypes with PROCA1: view

Animal Model Products

CRISPR Products

miRNA for PROCA1 Gene

miRTarBase miRNAs that target PROCA1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROCA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROCA1 Gene

Localization for PROCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROCA1 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PROCA1 Gene

Pathways & Interactions for PROCA1 Gene

SuperPathways for PROCA1 Gene

No Data Available

Interacting Proteins for PROCA1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301039%0d%0a9606.ENSP00000255465%0d%0a
Selected Interacting proteins: Q8NCQ7-PRCA1_HUMAN ENSP00000301039 for PROCA1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PROCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PROCA1: view

No data available for Pathways by source and SIGNOR curated interactions for PROCA1 Gene

Drugs & Compounds for PROCA1 Gene

No Compound Related Data Available

Transcripts for PROCA1 Gene

Unigene Clusters for PROCA1 Gene

Protein interacting with cyclin A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROCA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PROCA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - -

Relevant External Links for PROCA1 Gene

GeneLoc Exon Structure for
PROCA1
ECgene alternative splicing isoforms for
PROCA1

Expression for PROCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCA1 Gene

This gene is overexpressed in Testis (x26.7).

NURSA nuclear receptor signaling pathways regulating expression of PROCA1 Gene:

PROCA1

SOURCE GeneReport for Unigene cluster for PROCA1 Gene:

Hs.207471

mRNA Expression by UniProt/SwissProt for PROCA1 Gene:

Q8NCQ7-PRCA1_HUMAN
Tissue specificity: High expressed in testis.
genes like me logo Genes that share expression patterns with PROCA1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROCA1 Gene

Orthologs for PROCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROCA1 33 34
  • 94.88 (n)
dog
(Canis familiaris)
Mammalia PROCA1 33 34
  • 81.85 (n)
cow
(Bos Taurus)
Mammalia PROCA1 33 34
  • 79.74 (n)
rat
(Rattus norvegicus)
Mammalia Proca1 33
  • 68.21 (n)
mouse
(Mus musculus)
Mammalia Proca1 34 16 33
  • 60.16 (n)
OneToOne
chicken
(Gallus gallus)
Aves PROCA1 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROCA1 34
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii proca1 34
  • 9 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sPLA2 34
  • 14 (a)
ManyToMany
GIIIspla2 34
  • 12 (a)
ManyToMany
CG30503 34
  • 12 (a)
ManyToMany
CG3009 34
  • 8 (a)
ManyToMany
CG42237 34
  • 4 (a)
ManyToMany
Species where no ortholog for PROCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROCA1 Gene

ENSEMBL:
Gene Tree for PROCA1 (if available)
TreeFam:
Gene Tree for PROCA1 (if available)

Paralogs for PROCA1 Gene

Paralogs for PROCA1 Gene

genes like me logo Genes that share paralogs with PROCA1: view

Variants for PROCA1 Gene

Sequence variations from dbSNP and Humsavar for PROCA1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000544647 -- 28,706,106(+) TGGGT(C/T)CTCAC intron-variant
rs1000789179 -- 28,705,097(+) GTCCT(C/T)TCCCT intron-variant
rs1000847800 -- 28,709,494(+) TCGTG(A/G)TCCGC intron-variant, upstream-variant-2KB
rs1000879019 -- 28,709,877(+) CTGTA(A/G)TCCCA intron-variant, upstream-variant-2KB
rs1001158659 -- 28,713,224(+) GGACA(A/C)CCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PROCA1 Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958

Variation tolerance for PROCA1 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROCA1 Gene

Human Gene Mutation Database (HGMD)
PROCA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCA1 Gene

Disorders for PROCA1 Gene

Relevant External Links for PROCA1

Genetic Association Database (GAD)
PROCA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROCA1

No disorders were found for PROCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROCA1 Gene

Publications for PROCA1 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S … Müller-Tidow C (The Journal of biological chemistry 2004) 2 3 4 60
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for PROCA1 Gene

Sources for PROCA1 Gene

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