Aliases for PROC Gene
External Ids for PROC Gene
Previous GeneCards Identifiers for PROC Gene
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
GeneCards Summary for PROC Gene
PROC (Protein C (Inactivator Of Coagulation Factors Va And VIIIa)) is a Protein Coding gene. Diseases associated with PROC include protein c deficiency and hereditary thrombophilia due to congenital protein c deficiency. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include calcium ion binding and peptidase activity. An important paralog of this gene is HP.
UniProtKB/Swiss-Prot for PROC Gene
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.