PROC Gene

Aliases
for PROC gene

Previous GC identifers: GC02P125475 GC02P126102 GC02P128080 GC02P128269 GC02P127892 GC02P120483

Summaries
for PROC gene

Genomic Views
for PROC gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022135.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): PROC promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROC

PROC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P128176:  view genomic region     (about GC identifiers)

Proteins
for PROC gene

6/7 PDB 3D structures from and Proteopedia for PROC (see all 7):

1AUT (3D)        1LQV (3D)        1PCU (3D)        2PCT (3D)        3F6U (3D)        3JTC (3D)    

Explore the universe of human proteins at neXtProt for PROC: NX_P04070

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for PROC (Coagulation Factor XIV/Protein C)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PROC OriGene Protein Over-expression Lysate: PROC OriGene Custom Protein Services for PROC
	GenScript Custom Purified and Recombinant Proteins Services for PROC
	Novus Biologicals PROC Proteins Novus Biologicals PROC Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PROC
	Uscn Proteins for PROC

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PROC
	R&D Systems Antibodies for PROC (Coagulation Factor XIV/Protein C)
	OriGene Antibodies: PROC OriGene Custom Antibody Services for PROC
	GenScript Superior Antibodies for PROC
	Novus Biologicals PROC Antibodies
	Abcam antibodies for PROC
	Uscn Antibodies for PROC
	ThermoFisher Antibodies for PROC

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PROC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PROC

Protein Domains /
Families
for PROC gene

ProtoNet protein and cluster: P04070

Function
for PROC gene

miRNA Products:		miRTarBase miRNAs that target PROC: hsa-mir-210 (MIRT003183), hsa-mir-155 (MIRT001207)
		OriGene 3'-UTR Clone: PROC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROC
		1 QIAGEN miScript miRNA Assays for microRNA that regulate PROC:
		hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: PROC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PROC (see all 7) OriGene shRNA RFP: PROC OriGene siRNA: PROC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROC

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PROC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROC (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PROC (NM_000312)
		Sino Biological Human cDNA Clone for PROC
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PROC
		Search LifeMap BioReagents cell lines for PROC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROC

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Proc)

Pathways & Interactions
for PROC gene

	Super-pathway	contained gene-specific pathways
1	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 1.00 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 0.73 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.82 Warfarin Pathway, Pharmacodynamics 0.67 Gamma-carboxylation of protein precursors 0.82
2	Formation of Fibrin Clot (Clotting Cascade)	Formation of Fibrin Clot (Clotting Cascade) 1.00 Blood Coagulation Signaling Pathways 0.51
3	Common Pathway	Common Pathway 1.00 Extrinsic Prothrombin Activation Pathway 0.69
4	Blood Coagulation Cascade	Blood Coagulation Cascade 1.00 Intrinsic Prothrombin Activation Pathway 0.96
5	Complement and coagulation cascades	Complement and coagulation cascades 1.00 Complement and Coagulation Cascades 0.72

1 EMD Millipore Pathway for PROC

Selected targets of HNF1

1 R&D Systems Pathway for PROC

Blood Coagulation Signaling Pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PROC

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade
	Intrinsic Prothrombin Activation Pathway

1 BioSystems Pathway for PROC

Complement and Coagulation Cascades

5/11        Reactome Pathways for PROC

	Hemostasis
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Common Pathway
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

1 PharmGKB Pathway for PROC

Warfarin Pathway, Pharmacodynamics

1         Kegg Pathway  (Kegg details for PROC)

Complement and coagulation cascades

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for PROC gene

Transcripts
for PROC gene

Expression
for PROC gene

PROC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACAAGCAC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PROC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROC

Orthologs
for PROC gene

Paralogs
for PROC gene

Paralogs for PROC gene

PROZ²  PAMR1²  C1S²  C1R²  C1RL²  F9²  MASP1²  F10²  

F2²  HPR²  HP²  F7²  MASP2²  

18/106 SIMAP similar genes for PROC using alignment to 17 protein entries:     PROC_HUMAN (see all proteins) (see all similar genes):

PROC1    PROS1    PRRG3    PRRG1    GAS6    F2

PRSS42    SCUBE2    MEGF6    F9    F11    KLKB1

TMPRSS11B    TMPRSS11F    TMPRSS9    TMPRSS2    TMPRSS7    TMPRSS11A

PROC for paralogs           About GeneDecksing

Genomic Variants
for PROC gene

10/285 NCBI SNPs in PROC are shown (see all 285)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219181431,2	C	pathogenic	128183756(+)	ATCCGC/TGGCTC	2	R W	mis1		0	--	--	--	--
rs1219181521,2	C	pathogenic	128183783(+)	CCAGGC/TGGGGA	2	R W	mis1		0	--	--	--	--
rs1219181601,2	C	pathogenic	128186071(+)	CCTCTC/TGCAGA	2	S L	mis1		0	--	--	--	--
rs1219181571,2	C	pathogenic	128186471(+)	TGGATC/GCATGG	2	I M	mis1		1		NA	4546
rs1994694811,2	C	probable-pathogenic	128178996(+)	AGGCCA/GAGGAA	2	K E	mis1		0	--	--	--	--
rs1994694821,2	C	probable-pathogenic	128179030(+)	AGTAAA/GGCCAC	1	--	int1		0	--	--	--	--
rs1994694791,2	C	probable-pathogenic	128180663(+)	TGTGCG/TGCGGG	3	G C	mis1 ds5001		0	--	--	--	--
rs1994694771,2	C	probable-pathogenic	128180696(+)	TCGGC-/AGCT           TCAGC	3	S SF	fra1 ds5001		0	--	--	--	--
rs1994694741,2	C	probable-pathogenic	128180973(+)	GCAGTA/GTCACC	3	Y C	mis1 ds5001		0	--	--	--	--
rs1469223251,2	C,	probable-pathogenic	128183690(+)	GGAAGC/TGGATG	2	R W	mis1		1		NA	4552

HapMap Linkage Disequilibrium report for PROC (128175996 - 128186822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PROC: --
Human Gene Mutation Database (HGMD): PROC

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROC

DNA2.0 Custom Variant and Variant Library Synthesis for PROC

Disorders / Diseases
for PROC gene

20/70 diseases for PROC

10/15 Novoseek disease relationships for PROC gene (see all 15)    About this table

Publications
for PROC gene

PubMed articles for PROC gene, integrated from 9 sources (see all 407): (articles sorted by number of sources associating them with PROC)

Utopia: connect your pdf to the dynamic world of online information

1. Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene. (PubMed id 2437584)^{1, 2, 3} Romeo G....Peschle C. (1987)
2. The nucleotide sequence of the gene for human protein C. (PubMed id 2991887)^{1, 2, 3} Foster D.C.... Davie E.W. (1985)
3. Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels. (PubMed id 9798967)^{1, 2, 9} Couture P.... Simard J. (1998)
4. R147W mutation of PROC gene is common in venous thrombotic patients in Taiwanese Chinese. (PubMed id 15114590)^{1, 4, 9} Tsay W. and Shen M.C. (2004)
5. A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy. (PubMed id 7841323)^{1, 2, 9} Millar D.S.... Cooper D.N. (1994)
6. Three novel mutations in the protein C (PROC) gene causing venous thrombosis. (PubMed id 7605880)^{1, 2, 9} Millar D.S.... Cooper D.N. (1995)
7. A Gla domain mutation (Arg 15-->Trp) in the protein C (PROC) gene causing type 2 protein C deficiency and recurrent venous thrombosis. (PubMed id 8499568)^{1, 2, 9} Millar D.S.... Cooper D.N. (1993)
8. A novel homozygous missense mutation in the protein C (PROC) gene causing recurrent venous thrombosis. (PubMed id 1511988)^{1, 2, 9} Grundy C.B.... Cooper D.N. (1992)
9. Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis. (PubMed id 1511989)^{1, 2, 9} Grundy C.B.... Cooper D.N. (1992)
10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)

External Searches for PROC gene

Genome Databases showing PROC gene

Other Databases showing PROC gene

Specialized Databases showing PROC gene

Products
for PROC gene