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Aliases for PROB1 Gene

Aliases for PROB1 Gene

  • Proline Rich Basic Protein 1 2 3 5
  • C5orf65 3 4
  • Weakly Similar To Basic Proline-Rich Protein 3
  • Chromosome 5 Open Reading Frame 65 2
  • Proline-Rich Basic Protein 1 3

External Ids for PROB1 Gene

Previous HGNC Symbols for PROB1 Gene

  • C5orf65

Previous GeneCards Identifiers for PROB1 Gene

  • GC05M138728

Summaries for PROB1 Gene

GeneCards Summary for PROB1 Gene

PROB1 (Proline Rich Basic Protein 1) is a Protein Coding gene.

Additional gene information for PROB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROB1 Gene

Genomics for PROB1 Gene

Regulatory Elements for PROB1 Gene

Enhancers for PROB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H139341 1.2 ENCODE 12.5 +53.4 53399 2 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZNF610 ZNF585B GLIS1 KDM3B PURA RPL7P19 ENSG00000232174 SLC23A1 MZB1 PROB1 MATR3 SNORA74A SIL1
GH05H139413 1 Ensembl ENCODE 11.9 -21.3 -21337 6 CTCF SMARCA5 ZNF362 HLF ZNF175 FEZF1 REST RAD21 NR2F2 NFIC DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 GC05P139410
GH05H139422 0.8 ENCODE 11.8 -26.8 -26774 0 CTCF RB1 ARID4B KLF17 MAX ZNF2 ZSCAN9 RAD21 RFX5 CC2D1A DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 GC05P139409
GH05H139436 0.8 ENCODE 11.1 -41.6 -41628 1 HDGF PKNOX1 TBL1XR1 BMI1 BATF ZSCAN5C ZNF143 ZNF207 ATF7 ETV6 DNAJC18 PROB1 MZB1 SLC23A1 GC05P139410 GC05P139409
GH05H139368 0.6 ENCODE 13.8 +26.4 26407 1 CTCF ZNF654 ZNF366 SCRT2 ZNF629 ZNF600 RAD21 DNAJC18 MZB1 PROB1 PAIP2 SIL1 MATR3 ENSG00000272742 PIR39115
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROB1 on UCSC Golden Path with GeneCards custom track

Promoters for PROB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187637 713 401 CTBP2 EZH2
ENSR00000317496 1413 201 SMARCA5 CTCF ZNF687 RB1 NR2F1 BACH1 TRIM22 RAD21 ZNF592 TARDBP

Genomic Location for PROB1 Gene

Chromosome:
5
Start:
139,390,592 bp from pter
End:
139,395,713 bp from pter
Size:
5,122 bases
Orientation:
Minus strand

Genomic View for PROB1 Gene

Genes around PROB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROB1 Gene

Proteins for PROB1 Gene

  • Protein details for PROB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7EW31-PROB1_HUMAN
    Recommended name:
    Proline-rich basic protein 1
    Protein Accession:
    E7EW31
    Secondary Accessions:
    • B4E007

    Protein attributes for PROB1 Gene

    Size:
    1015 amino acids
    Molecular mass:
    106917 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG64269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH14854.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PROB1 Gene

Post-translational modifications for PROB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROB1 Gene

Domains & Families for PROB1 Gene

Gene Families for PROB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROB1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROB1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROB1 Gene

Function for PROB1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PROB1 Gene

Localization for PROB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROB1 gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROB1 Gene

Pathways & Interactions for PROB1 Gene

SuperPathways for PROB1 Gene

No Data Available

Interacting Proteins for PROB1 Gene

Gene Ontology (GO) - Biological Process for PROB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROB1 Gene

Drugs & Compounds for PROB1 Gene

No Compound Related Data Available

Transcripts for PROB1 Gene

mRNA/cDNA for PROB1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROB1 Gene

Proline-rich basic protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PROB1 Gene

No ASD Table

Relevant External Links for PROB1 Gene

GeneLoc Exon Structure for
PROB1
ECgene alternative splicing isoforms for
PROB1

Expression for PROB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROB1 Gene

mRNA differential expression in normal tissues according to GTEx for PROB1 Gene

This gene is overexpressed in Muscle - Skeletal (x17.8) and Heart - Left Ventricle (x7.1).

Protein differential expression in normal tissues from HIPED for PROB1 Gene

This gene is overexpressed in Pancreatic juice (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PROB1 Gene



Protein tissue co-expression partners for PROB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PROB1 Gene:

PROB1

SOURCE GeneReport for Unigene cluster for PROB1 Gene:

Hs.729482
genes like me logo Genes that share expression patterns with PROB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROB1 Gene

Orthologs for PROB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROB1 33 34
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia PROB1 33 34
  • 81.04 (n)
dog
(Canis familiaris)
Mammalia PROB1 33 34
  • 79.95 (n)
rat
(Rattus norvegicus)
Mammalia Prob1 33
  • 75.81 (n)
mouse
(Mus musculus)
Mammalia Prob1 33 16 34
  • 75.28 (n)
oppossum
(Monodelphis domestica)
Mammalia PROB1 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROB1 34
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PROB1 34
  • 15 (a)
OneToOne
Species where no ortholog for PROB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROB1 Gene

ENSEMBL:
Gene Tree for PROB1 (if available)
TreeFam:
Gene Tree for PROB1 (if available)

Paralogs for PROB1 Gene

No data available for Paralogs for PROB1 Gene

Variants for PROB1 Gene

Sequence variations from dbSNP and Humsavar for PROB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000037209 -- 139,395,931(+) TCACA(A/G)GGCCC upstream-variant-2KB, utr-variant-3-prime
rs1000257218 -- 139,393,599(+) CGGGC(G/T)GCTAC reference, missense
rs1000348803 -- 139,393,322(+) GCTCG(A/G/T)GTGCT reference, missense
rs1000518419 -- 139,394,934(+) TTTCG(C/T)GTCCG downstream-variant-500B, reference, missense
rs1000591429 -- 139,394,856(+) ATTCT(C/G)GGCGC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PROB1 Gene

Variant ID Type Subtype PubMed ID
nsv950410 CNV deletion 24416366

Variation tolerance for PROB1 Gene

Gene Damage Index Score: 13.17; 95.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROB1 Gene

Disorders for PROB1 Gene

Relevant External Links for PROB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROB1

No disorders were found for PROB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROB1 Gene

Publications for PROB1 Gene

  1. Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing. (PMID: 27703147) Karolak JA … Gajecka M (European journal of human genetics : EJHG 2016) 3 60
  2. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert TA … Walter MJ (PloS one 2009) 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 60

Products for PROB1 Gene

Sources for PROB1 Gene

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