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Aliases for PROB1 Gene

Aliases for PROB1 Gene

  • Proline-Rich Basic Protein 1 2 3
  • C5orf65 3 4
  • Weakly Similar To Basic Proline-Rich Protein 3
  • Chromosome 5 Open Reading Frame 65 2

External Ids for PROB1 Gene

Previous Symbols for PROB1 Gene

  • C5orf65

Summaries for PROB1 Gene

GeneCards Summary for PROB1 Gene

PROB1 (Proline-Rich Basic Protein 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROB1 Gene

Genomics for PROB1 Gene

Genomic Location for PROB1 Gene

139,390,592 bp from pter
139,395,713 bp from pter
5,122 bases
Minus strand

Genomic View for PROB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROB1 Gene

No data available for Regulatory Elements for PROB1 Gene

Proteins for PROB1 Gene

  • Protein details for PROB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich basic protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E007

    Protein attributes for PROB1 Gene

    1015 amino acids
    Molecular mass:
    106917 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG64269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH14854.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PROB1 Gene

Proteomics data for PROB1 Gene at MOPED

Post-translational modifications for PROB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROB1 Gene

Domains for PROB1 Gene

Protein Domains for PROB1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROB1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROB1 Gene

Function for PROB1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PROB1 Gene

Localization for PROB1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PROB1 Gene

Pathways for PROB1 Gene

SuperPathways for PROB1 Gene

No Data Available

Interacting Proteins for PROB1 Gene

Gene Ontology (GO) - Biological Process for PROB1 Gene


No data available for Pathways by source for PROB1 Gene

Transcripts for PROB1 Gene

mRNA/cDNA for PROB1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROB1 Gene

Proline-rich basic protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROB1 Gene

No ASD Table

Relevant External Links for PROB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PROB1 Gene

mRNA expression in normal human tissues for PROB1 Gene

mRNA differential expression in normal tissues according to GTEx for PROB1 Gene

This gene is overexpressed in Muscle - Skeletal (17.8) and Heart - Left Ventricle (7.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PROB1 Gene

SOURCE GeneReport for Unigene cluster for PROB1 Gene Hs.729482

genes like me logo Genes that share expressions with PROB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PROB1 Gene

Orthologs for PROB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PROB1 35
  • 98.31 (n)
  • 98.03 (a)
PROB1 36
  • 98 (a)
(Bos Taurus)
Mammalia PROB1 35
  • 81.04 (n)
  • 73.79 (a)
PROB1 36
  • 73 (a)
(Canis familiaris)
Mammalia PROB1 35
  • 79.95 (n)
  • 72.01 (a)
PROB1 36
  • 71 (a)
(Mus musculus)
Mammalia Prob1 35
  • 75.28 (n)
  • 69.47 (a)
Prob1 36
  • 68 (a)
(Monodelphis domestica)
Mammalia PROB1 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Prob1 35
  • 75.81 (n)
  • 69.68 (a)
(Anolis carolinensis)
Reptilia PROB1 36
  • 38 (a)
(Danio rerio)
Actinopterygii PROB1 36
  • 15 (a)
Species with no ortholog for PROB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROB1 Gene

Gene Tree for PROB1 (if available)
Gene Tree for PROB1 (if available)

Paralogs for PROB1 Gene

No data available for Paralogs for PROB1 Gene

Variants for PROB1 Gene

Sequence variations from dbSNP and Humsavar for PROB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7356760 -- 139,395,338(+) TGACA(A/G)GCAGG upstream-variant-2KB
rs7447765 -- 139,394,404(+) gggcg(C/T)ggcgc synonymous-codon, reference
rs10063870 -- 139,392,844(+) GTTAC(C/T)TCGGG synonymous-codon, reference
rs10078623 -- 139,392,794(+) CCTCT(A/G)CATCC missense, reference
rs11743760 -- 139,392,682(+) CCGGG(A/G)CGGGG reference, synonymous-codon

Relevant External Links for PROB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PROB1 Gene

Disorders for PROB1 Gene

No disorders were found for PROB1 Gene.

No data available for UniProtKB/Swiss-Prot for PROB1 Gene

Publications for PROB1 Gene

  1. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for PROB1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PROB1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PROB1
    • Block miRNA regulation of PROB1 using miScript Target Protectors

    Sources for PROB1 Gene

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