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Aliases for PROB1 Gene

Aliases for PROB1 Gene

  • Proline Rich Basic Protein 1 2 3 5
  • C5orf65 3 4
  • Weakly Similar To Basic Proline-Rich Protein 3
  • Chromosome 5 Open Reading Frame 65 2
  • Proline-Rich Basic Protein 1 3

External Ids for PROB1 Gene

Previous HGNC Symbols for PROB1 Gene

  • C5orf65

Previous GeneCards Identifiers for PROB1 Gene

  • GC05M138728

Summaries for PROB1 Gene

GeneCards Summary for PROB1 Gene

PROB1 (Proline Rich Basic Protein 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROB1 Gene

Genomics for PROB1 Gene

Regulatory Elements for PROB1 Gene

Enhancers for PROB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G139413 1.4 Ensembl ENCODE 11.9 -21.3 -21337 6.6 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 DNAJC18 IGIP RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 LRRTM2 SIL1
GH05G139341 1.2 ENCODE 12.5 +53.4 53399 2.6 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZNF610 KDM3B PURA RPL7P19 SLC23A1 MZB1 PROB1 MATR3 SNORA74A SIL1 ENSG00000222937
GH05G139436 0.9 ENCODE 11.1 -41.6 -41628 1.1 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 ZSCAN5C ZNF143 ZNF207 DNAJC18 PROB1 MZB1 SLC23A1 GC05P139409 GC05P139410
GH05G139368 0.7 ENCODE 13.8 +26.4 26407 1.2 BCOR CTCF RAD21 GATA3 ZNF316 ZNF366 SCRT2 ZNF600 MAFK ZNF654 DNAJC18 MZB1 PROB1 PAIP2 SIL1 MATR3 ENSG00000272742 PIR39115
GH05G139422 0.8 ENCODE 11.9 -26.8 -26774 0.2 CTCF RB1 ARID4B KLF17 MAX ZNF2 ZSCAN9 RAD21 ZNF101 RFX5 DNAJC18 RNU5B-4P ECSCR PROB1 MZB1 SLC23A1 PAIP2 SIL1 MATR3 GC05P139409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROB1 on UCSC Golden Path with GeneCards custom track

Promoters for PROB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187637 196 401 ZGPAT POLR2A CHD1 CTBP2 KDM6A EZH2 TEAD3
ENSR00000317496 896 201 CTCF USF1 SUZ12 NR2F1 BACH1 TRIM22 USF2 REST UBTF RAD21

Genomic Location for PROB1 Gene

Chromosome:
5
Start:
139,390,592 bp from pter
End:
139,395,713 bp from pter
Size:
5,122 bases
Orientation:
Minus strand

Genomic View for PROB1 Gene

Genes around PROB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROB1 Gene

Proteins for PROB1 Gene

  • Protein details for PROB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7EW31-PROB1_HUMAN
    Recommended name:
    Proline-rich basic protein 1
    Protein Accession:
    E7EW31
    Secondary Accessions:
    • B4E007

    Protein attributes for PROB1 Gene

    Size:
    1015 amino acids
    Molecular mass:
    106917 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG64269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH14854.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PROB1 Gene

Post-translational modifications for PROB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROB1 Gene

Domains & Families for PROB1 Gene

Protein Domains for PROB1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROB1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROB1 Gene

Function for PROB1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PROB1 Gene

Localization for PROB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROB1 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROB1 Gene

Pathways & Interactions for PROB1 Gene

SuperPathways for PROB1 Gene

No Data Available

Interacting Proteins for PROB1 Gene

Gene Ontology (GO) - Biological Process for PROB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROB1 Gene

Drugs & Compounds for PROB1 Gene

No Compound Related Data Available

Transcripts for PROB1 Gene

mRNA/cDNA for PROB1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROB1 Gene

Proline-rich basic protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROB1 Gene

No ASD Table

Relevant External Links for PROB1 Gene

GeneLoc Exon Structure for
PROB1
ECgene alternative splicing isoforms for
PROB1

Expression for PROB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROB1 Gene

mRNA differential expression in normal tissues according to GTEx for PROB1 Gene

This gene is overexpressed in Muscle - Skeletal (x17.8) and Heart - Left Ventricle (x7.1).

Protein differential expression in normal tissues from HIPED for PROB1 Gene

This gene is overexpressed in Pancreatic juice (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PROB1 Gene



Protein tissue co-expression partners for PROB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PROB1 Gene:

PROB1

SOURCE GeneReport for Unigene cluster for PROB1 Gene:

Hs.729482
genes like me logo Genes that share expression patterns with PROB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROB1 Gene

Orthologs for PROB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROB1 34 35
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia PROB1 34 35
  • 81.04 (n)
dog
(Canis familiaris)
Mammalia PROB1 34 35
  • 79.95 (n)
rat
(Rattus norvegicus)
Mammalia Prob1 34
  • 75.81 (n)
mouse
(Mus musculus)
Mammalia Prob1 34 16 35
  • 75.28 (n)
oppossum
(Monodelphis domestica)
Mammalia PROB1 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROB1 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PROB1 35
  • 15 (a)
OneToOne
Species where no ortholog for PROB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROB1 Gene

ENSEMBL:
Gene Tree for PROB1 (if available)
TreeFam:
Gene Tree for PROB1 (if available)

Paralogs for PROB1 Gene

No data available for Paralogs for PROB1 Gene

Variants for PROB1 Gene

Sequence variations from dbSNP and Humsavar for PROB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000037209 -- 139,395,931(+) TCACA(A/G)GGCCC upstream-variant-2KB, utr-variant-3-prime
rs1000257218 -- 139,393,599(+) CGGGC(G/T)GCTAC reference, missense
rs1000348803 -- 139,393,322(+) GCTCG(A/G/T)GTGCT reference, missense
rs1000518419 -- 139,394,934(+) TTTCG(C/T)GTCCG downstream-variant-500B, reference, missense
rs1000591429 -- 139,394,856(+) ATTCT(C/G)GGCGC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PROB1 Gene

Variant ID Type Subtype PubMed ID
nsv950410 CNV deletion 24416366

Variation tolerance for PROB1 Gene

Gene Damage Index Score: 13.17; 95.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROB1 Gene

Disorders for PROB1 Gene

Relevant External Links for PROB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROB1

No disorders were found for PROB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROB1 Gene

Publications for PROB1 Gene

  1. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for PROB1 Gene

Sources for PROB1 Gene

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