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Aliases for PRNT Gene

Subcategory (RNA class) for PRNT Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PRNT Gene

  • Prion Locus LncRNA, Testis Expressed 2 3
  • Prion Protein (Testis Specific) 2 3 5
  • M8 Protein 2
  • Protein M8 4
  • M8 3

External Ids for PRNT Gene

Previous GeneCards Identifiers for PRNT Gene

  • GC00U991277

Summaries for PRNT Gene

GeneCards Summary for PRNT Gene

PRNT (Prion Locus LncRNA, Testis Expressed) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PRNT include Venezuelan Hemorrhagic Fever and Variola Major.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRNT Gene

Genomics for PRNT Gene

Regulatory Elements for PRNT Gene

Enhancers for PRNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G004760 1.6 FANTOM5 ENCODE dbSUPER 22.2 -20.4 -20420 1.8 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF143 ZNF207 FOS ZHX2 PRNT RASSF2 TMEM230 SLC23A2 PRNP ENSG00000278595
GH20G004766 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.5 -26.2 -26227 1.7 BCOR HDAC1 PKNOX1 TAL1 MAX TCF12 FOXM1 FOXK2 GATA2 NCOR1 PRNT RASSF2 SLC23A2 GC20P004769 ENSG00000278595
GH20G004961 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -221.3 -221346 1.6 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ELK1 FOS RASSF2 PRNT LOC100421361 TMEM230 PRND CDS2 SLC23A2 GC20M004944
GH20G004972 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -233.0 -233003 2.9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 YY1 SLC30A9 TMEM230 PRNT LOC100421361 SLC23A2 RASSF2 PRNP CDS2 GC20M004944
GH20G004808 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -71.9 -71881 8.0 HDGF PKNOX1 WRNIP1 SIN3A ZNF48 FOS ZNF263 JUNB TBX21 PBX2 RASSF2 PRNT LOC100421361 CDS2 SLC23A2 LOC105372511
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRNT on UCSC Golden Path with GeneCards custom track

Genomic Location for PRNT Gene

Chromosome:
20
Start:
4,731,282 bp from pter
End:
4,740,668 bp from pter
Size:
9,387 bases
Orientation:
Minus strand

Genomic View for PRNT Gene

Genes around PRNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRNT Gene

Proteins for PRNT Gene

  • Protein details for PRNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SH4-PRNT_HUMAN
    Recommended name:
    Putative testis-specific prion protein
    Protein Accession:
    Q86SH4
    Secondary Accessions:
    • B2RPD9
    • B7ZBI9

    Protein attributes for PRNT Gene

    Size:
    94 amino acids
    Molecular mass:
    10756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This putative protein is only present in primates and not in other mammals.

neXtProt entry for PRNT Gene

Post-translational modifications for PRNT Gene

Other Protein References for PRNT Gene

No data available for DME Specific Peptides for PRNT Gene

Domains & Families for PRNT Gene

Gene Families for PRNT Gene

Protein Domains for PRNT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRNT: view

No data available for UniProtKB/Swiss-Prot for PRNT Gene

Function for PRNT Gene

genes like me logo Genes that share phenotypes with PRNT: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRNT

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRNT Gene

Localization for PRNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRNT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRNT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRNT: view

Pathways & Interactions for PRNT Gene

No Data Available

Interacting Proteins for PRNT Gene

Gene Ontology (GO) - Biological Process for PRNT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRNT Gene

Drugs & Compounds for PRNT Gene

No Compound Related Data Available

Transcripts for PRNT Gene

mRNA/cDNA for PRNT Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRNT Gene

Prion protein (testis specific):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRNT

Alternative Splicing Database (ASD) splice patterns (SP) for PRNT Gene

ExUns: 1a · 1b ^ 2
SP1: -
SP2:

Relevant External Links for PRNT Gene

GeneLoc Exon Structure for
PRNT
ECgene alternative splicing isoforms for
PRNT

Expression for PRNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRNT Gene

mRNA differential expression in normal tissues according to GTEx for PRNT Gene

This gene is overexpressed in Testis (x52.9).

NURSA nuclear receptor signaling pathways regulating expression of PRNT Gene:

PRNT

SOURCE GeneReport for Unigene cluster for PRNT Gene:

Hs.126516

mRNA Expression by UniProt/SwissProt for PRNT Gene:

Q86SH4-PRNT_HUMAN
Tissue specificity: Specifically expressed in adult testis.
genes like me logo Genes that share expression patterns with PRNT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRNT Gene

Orthologs for PRNT Gene

Evolution for PRNT Gene

ENSEMBL:
Gene Tree for PRNT (if available)
TreeFam:
Gene Tree for PRNT (if available)

No data available for Orthologs for PRNT Gene

Paralogs for PRNT Gene

No data available for Paralogs for PRNT Gene

Variants for PRNT Gene

Sequence variations from dbSNP and Humsavar for PRNT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000039558 -- 4,736,869(+) GATTG(C/G)CAAGG intron-variant
rs1000173804 -- 4,731,535(+) TGCAA(A/C)TCTGC nc-transcript-variant
rs1000205227 -- 4,731,777(+) CCTCA(C/T)CTTGG nc-transcript-variant
rs1001007733 -- 4,741,243(+) TGTGA(A/G)TCTGT upstream-variant-2KB
rs1001086015 -- 4,731,616(+) CCAAG(A/G)GCAGG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PRNT Gene

Variant ID Type Subtype PubMed ID
esv3584432 CNV loss 25503493
esv3645074 CNV gain 21293372
nsv512602 CNV loss 21212237
nsv585310 CNV gain 21841781

Variation tolerance for PRNT Gene

Gene Damage Index Score: 0.26; 5.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRNT Gene

Disorders for PRNT Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRNT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
venezuelan hemorrhagic fever
  • guanarito hemorrhagic fever
variola major
  • smallpox
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
korean hemorrhagic fever
  • hemorrhagic fever with renal syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRNT in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRNT

Genetic Association Database (GAD)
PRNT
Human Genome Epidemiology (HuGE) Navigator
PRNT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRNT
genes like me logo Genes that share disorders with PRNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRNT Gene

Publications for PRNT Gene

  1. Genomic characterization of the human prion protein (PrP) gene locus. (PMID: 12514748) Makrinou E. … Antoniou M. (Mamm. Genome 2002) 2 3 4 22 64
  2. Genomic assessment of the evolution of the prion protein gene family in vertebrates. (PMID: 20206252) Harrison P.M. … Kumar M. (Genomics 2010) 2 3 64
  3. Comparative genomic analysis of prion genes. (PMID: 17199895) Premzl M. … Gamulin V. (BMC Genomics 2007) 3 4 64
  4. Comparative genomic organization of the human and bovine PRNP locus. (PMID: 16460908) Choi S.-H. … Park H.-S. (Genomics 2006) 3 4 64
  5. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients. (PMID: 16889908) Geldermann H. … Zerr I. (Gene 2006) 3 46 64

Products for PRNT Gene

Sources for PRNT Gene

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