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Aliases for PRNT Gene

Subcategory (RNA class) for PRNT Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for PRNT Gene

  • Prion Protein (Testis Specific) 2 3 5
  • M8 Protein 2
  • Protein M8 4
  • M8 3

External Ids for PRNT Gene

Previous GeneCards Identifiers for PRNT Gene

  • GC00U991277

Summaries for PRNT Gene

GeneCards Summary for PRNT Gene

PRNT (Prion Protein (Testis Specific)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with PRNT include Venezuelan Hemorrhagic Fever and Creutzfeldt-Jakob Disease.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRNT Gene

Genomics for PRNT Gene

Regulatory Elements for PRNT Gene

Enhancers for PRNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F004760 1.3 FANTOM5 ENCODE 22.2 -20.4 -20420 1.8 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF143 FOS MXD4 MIER2 REST PRNT RASSF2 TMEM230 SLC23A2 PRNP ENSG00000278595
GH20F004037 1.7 FANTOM5 Ensembl ENCODE 16.2 +702.4 702368 2.2 HDGF PKNOX1 ATF1 FEZF1 ZNF2 YY1 GLIS2 FOS SP3 YY2 ENSG00000236387 PRNT RN7SL555P LOC100421361 ENSG00000229539 RNF24 UBOX5-AS1 MAVS PANK2 FTLP3
GH20F003795 1.5 FANTOM5 ENCODE 16.2 +938.6 938615 14.1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 CDC25B ENSG00000236387 RN7SL555P LOC100421361 PRNT VPS16 SPEF1 ENSG00000229539 UBOX5-AS1 PANK2
GH20F004961 1.6 FANTOM5 Ensembl ENCODE 12.1 -221.2 -221246 1.8 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 FOS ZNF263 SP5 MCM8 RASSF2 PRNT LOC100421361 TMEM230 PRND CDS2 SLC23A2 GC20M004944
GH20F004765 1.3 FANTOM5 Ensembl ENCODE 14.5 -26.1 -26095 1.9 BCOR PKNOX1 TAL1 MAX NCOR1 GATA2 MTA2 RNF2 HLF DPF2 PRNT RASSF2 SLC23A2 GC20P004769 ENSG00000278595
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRNT on UCSC Golden Path with GeneCards custom track

Genomic Location for PRNT Gene

Chromosome:
20
Start:
4,731,282 bp from pter
End:
4,740,668 bp from pter
Size:
9,387 bases
Orientation:
Minus strand

Genomic View for PRNT Gene

Genes around PRNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRNT Gene

Proteins for PRNT Gene

  • Protein details for PRNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SH4-PRNT_HUMAN
    Recommended name:
    Putative testis-specific prion protein
    Protein Accession:
    Q86SH4
    Secondary Accessions:
    • B2RPD9
    • B7ZBI9

    Protein attributes for PRNT Gene

    Size:
    94 amino acids
    Molecular mass:
    10756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This putative protein is only present in primates and not in other mammals.

neXtProt entry for PRNT Gene

Post-translational modifications for PRNT Gene

Other Protein References for PRNT Gene

No data available for DME Specific Peptides for PRNT Gene

Domains & Families for PRNT Gene

Protein Domains for PRNT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRNT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRNT Gene

Function for PRNT Gene

genes like me logo Genes that share phenotypes with PRNT: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRNT Gene

Localization for PRNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRNT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRNT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRNT: view

Pathways & Interactions for PRNT Gene

No Data Available

Interacting Proteins for PRNT Gene

Gene Ontology (GO) - Biological Process for PRNT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRNT Gene

Transcripts for PRNT Gene

mRNA/cDNA for PRNT Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRNT Gene

Prion protein (testis specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRNT Gene

ExUns: 1a · 1b ^ 2
SP1: -
SP2:

Relevant External Links for PRNT Gene

GeneLoc Exon Structure for
PRNT
ECgene alternative splicing isoforms for
PRNT

Expression for PRNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRNT Gene

mRNA differential expression in normal tissues according to GTEx for PRNT Gene

This gene is overexpressed in Testis (x52.9).

NURSA nuclear receptor signaling pathways regulating expression of PRNT Gene:

PRNT

SOURCE GeneReport for Unigene cluster for PRNT Gene:

Hs.126516

mRNA Expression by UniProt/SwissProt for PRNT Gene:

Q86SH4-PRNT_HUMAN
Tissue specificity: Specifically expressed in adult testis.
genes like me logo Genes that share expression patterns with PRNT: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRNT Gene

Orthologs for PRNT Gene

Evolution for PRNT Gene

ENSEMBL:
Gene Tree for PRNT (if available)
TreeFam:
Gene Tree for PRNT (if available)

No data available for Orthologs for PRNT Gene

Paralogs for PRNT Gene

No data available for Paralogs for PRNT Gene

Variants for PRNT Gene

Sequence variations from dbSNP and Humsavar for PRNT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1040872 -- 4,733,581(-) ACAGA(C/G)GCCTG intron-variant
rs111408000 -- 4,735,104(+) CCGTC(G/T)CTCGG intron-variant
rs111436702 -- 4,742,037(+) TGGAT(A/G)CTGAA upstream-variant-2KB
rs111740136 -- 4,733,420(+) TTCTC(-/A)AAAAA intron-variant
rs111840404 -- 4,735,308(+) CCATG(C/G)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRNT Gene

Variant ID Type Subtype PubMed ID
nsv585310 CNV gain 21841781
nsv512602 CNV loss 21212237
esv3645074 CNV gain 21293372
esv3584432 CNV loss 25503493

Variation tolerance for PRNT Gene

Gene Damage Index Score: 0.26; 5.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRNT Gene

Disorders for PRNT Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRNT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
venezuelan hemorrhagic fever
  • guanarito hemorrhagic fever
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
variola major
  • smallpox
korean hemorrhagic fever
  • hemorrhagic fever with renal syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRNT in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRNT

Genetic Association Database (GAD)
PRNT
Human Genome Epidemiology (HuGE) Navigator
PRNT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRNT
genes like me logo Genes that share disorders with PRNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRNT Gene

Publications for PRNT Gene

  1. Genomic characterization of the human prion protein (PrP) gene locus. (PMID: 12514748) Makrinou E. … Antoniou M. (Mamm. Genome 2002) 2 3 4 22 64
  2. Comparative genomic analysis of prion genes. (PMID: 17199895) Premzl M. … Gamulin V. (BMC Genomics 2007) 3 4 64
  3. Comparative genomic organization of the human and bovine PRNP locus. (PMID: 16460908) Choi S.-H. … Park H.-S. (Genomics 2006) 3 4 64
  4. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients. (PMID: 16889908) Geldermann H. … Zerr I. (Gene 2006) 3 46 64
  5. Genomic assessment of the evolution of the prion protein gene family in vertebrates. (PMID: 20206252) Harrison P.M. … Kumar M. (Genomics 2010) 3 64

Products for PRNT Gene

Sources for PRNT Gene

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