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Aliases for PRNT Gene

Subcategory (RNA class) for PRNT Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PRNT Gene

  • Prion Locus LncRNA, Testis Expressed 2 3 5
  • Prion Protein (Testis Specific) 2 3
  • M8 Protein 2
  • Protein M8 4
  • M8 3

External Ids for PRNT Gene

Previous GeneCards Identifiers for PRNT Gene

  • GC00U991277

Summaries for PRNT Gene

GeneCards Summary for PRNT Gene

PRNT (Prion Locus LncRNA, Testis Expressed) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PRNT include Venezuelan Hemorrhagic Fever and Variola Major.

Additional gene information for PRNT Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRNT Gene

Genomics for PRNT Gene

GeneHancer (GH) Regulatory Elements for PRNT Gene

Promoters and enhancers for PRNT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I004740 Enhancer 0.6 ENCODE 550.8 -0.3 -322 0.2 CTCF ZNF654 FOXA2 L3MBTL2 TEAD1 TRIM22 ELF1 ZIC2 RAD21 ZKSCAN1 PRNT AP5S1 ENSG00000278595
GH20I004760 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.2 -20.4 -20420 1.8 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ARID2 ZNF207 ZNF143 FOS ENSG00000278595 PRNT RASSF2 TMEM230 SLC23A2 PRNP
GH20I004998 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 -259.5 -259471 4.3 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 SLC23A2 TMEM230 PRNT LOC100421361 PRNP GC20M004944
GH20I004949 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -210.3 -210270 2.4 HDGF CTCF JUN CEBPG RAD21 YY1 LCORL HSF1 HNF4G FOSL2 SLC23A2 LOC100421361 PRNT RASSF2 ENSG00000252096 PRNP PRND LINC00658 GC20M004944 GC20P004944
GH20I004684 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 +53.7 53714 5.5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF213 PRNP PRND LOC100421361 PRNT GC20P004700
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRNT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRNT gene promoter:

Genomic Locations for PRNT Gene

Genomic Locations for PRNT Gene
chr20:4,731,282-4,740,668
(GRCh38/hg38)
Size:
9,387 bases
Orientation:
Minus strand
chr20:4,711,928-4,721,314
(GRCh37/hg19)

Genomic View for PRNT Gene

Genes around PRNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRNT Gene

Proteins for PRNT Gene

  • Protein details for PRNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SH4-PRNT_HUMAN
    Recommended name:
    Putative testis-specific prion protein
    Protein Accession:
    Q86SH4
    Secondary Accessions:
    • B2RPD9
    • B7ZBI9

    Protein attributes for PRNT Gene

    Size:
    94 amino acids
    Molecular mass:
    10756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This putative protein is only present in primates and not in other mammals.

neXtProt entry for PRNT Gene

Post-translational modifications for PRNT Gene

Other Protein References for PRNT Gene

No data available for DME Specific Peptides for PRNT Gene

Domains & Families for PRNT Gene

Gene Families for PRNT Gene

Protein Domains for PRNT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRNT: view

No data available for UniProtKB/Swiss-Prot for PRNT Gene

Function for PRNT Gene

Phenotypes From GWAS Catalog for PRNT Gene

genes like me logo Genes that share phenotypes with PRNT: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRNT Gene

Localization for PRNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRNT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRNT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRNT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRNT Gene

Pathways & Interactions for PRNT Gene

No Data Available

Interacting Proteins for PRNT Gene

Gene Ontology (GO) - Biological Process for PRNT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRNT Gene

Drugs & Compounds for PRNT Gene

No Compound Related Data Available

Transcripts for PRNT Gene

mRNA/cDNA for PRNT Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRNT Gene

Prion protein (testis specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRNT Gene

ExUns: 1a · 1b ^ 2
SP1: -
SP2:

Relevant External Links for PRNT Gene

GeneLoc Exon Structure for
PRNT
ECgene alternative splicing isoforms for
PRNT

Expression for PRNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRNT Gene

mRNA differential expression in normal tissues according to GTEx for PRNT Gene

This gene is overexpressed in Testis (x52.9).

NURSA nuclear receptor signaling pathways regulating expression of PRNT Gene:

PRNT

SOURCE GeneReport for Unigene cluster for PRNT Gene:

Hs.126516

mRNA Expression by UniProt/SwissProt for PRNT Gene:

Q86SH4-PRNT_HUMAN
Tissue specificity: Specifically expressed in adult testis.
genes like me logo Genes that share expression patterns with PRNT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRNT Gene

Orthologs for PRNT Gene

Evolution for PRNT Gene

ENSEMBL:
Gene Tree for PRNT (if available)
TreeFam:
Gene Tree for PRNT (if available)

No data available for Orthologs for PRNT Gene

Paralogs for PRNT Gene

No data available for Paralogs for PRNT Gene

Variants for PRNT Gene

Sequence variations from dbSNP and Humsavar for PRNT Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000039558 -- 4,736,869(-) G/C intron_variant
rs1000173804 -- 4,731,535(-) A/C non_coding_transcript_variant
rs1000205227 -- 4,731,777(-) T/C non_coding_transcript_variant
rs1001007733 -- 4,741,243(-) A/G upstream_transcript_variant
rs1001086015 -- 4,731,616(-) G/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRNT Gene

Variant ID Type Subtype PubMed ID
esv3584432 CNV loss 25503493
esv3645074 CNV gain 21293372
nsv512602 CNV loss 21212237
nsv585310 CNV gain 21841781

Variation tolerance for PRNT Gene

Gene Damage Index Score: 0.26; 5.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRNT Gene

Disorders for PRNT Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRNT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
venezuelan hemorrhagic fever
  • guanarito hemorrhagic fever
variola major
  • smallpox
creutzfeldt-jakob disease
  • cjd
korean hemorrhagic fever
  • hemorrhagic fever with renal syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRNT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRNT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRNT Gene

Publications for PRNT Gene

  1. Genomic characterization of the human prion protein (PrP) gene locus. (PMID: 12514748) Makrinou E … Antoniou M (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 2 3 4 22 58
  2. Genomic assessment of the evolution of the prion protein gene family in vertebrates. (PMID: 20206252) Harrison PM … Kumar M (Genomics 2010) 2 3 58
  3. Comparative genomic analysis of prion genes. (PMID: 17199895) Premzl M … Gamulin V (BMC genomics 2007) 3 4 58
  4. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients. (PMID: 16889908) Geldermann H … Zerr I (Gene 2006) 3 44 58
  5. Comparative genomic organization of the human and bovine PRNP locus. (PMID: 16460908) Choi SH … Park HS (Genomics 2006) 3 4 58

Products for PRNT Gene

Sources for PRNT Gene

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