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Aliases for PRND Gene

Aliases for PRND Gene

  • Prion Protein 2 (Dublet) 2 3 5
  • PrPLP 3 4
  • DPL 3 4
  • Prion Gene Complex, Downstream 3
  • Prion-Like Protein Doppel 2
  • Prion Protein 2 4
  • DJ1068H6.4 3
  • DOPPEL 3

External Ids for PRND Gene

Previous GeneCards Identifiers for PRND Gene

  • GC20P004690
  • GC20P004697
  • GC20P004650

Summaries for PRND Gene

Entrez Gene Summary for PRND Gene

  • This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRND Gene

PRND (Prion Protein 2 (Dublet)) is a Protein Coding gene. Diseases associated with PRND include Creutzfeldt-Jakob Disease and Familial Creutzfeldt-Jakob Disease.

Gene Wiki entry for PRND Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRND Gene

Genomics for PRND Gene

Regulatory Elements for PRND Gene

Enhancers for PRND Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRND on UCSC Golden Path with GeneCards custom track

Genomic Location for PRND Gene

4,721,854 bp from pter
4,728,462 bp from pter
6,609 bases
Plus strand

Genomic View for PRND Gene

Genes around PRND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRND Gene

Proteins for PRND Gene

  • Protein details for PRND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prion-like protein doppel
    Protein Accession:
    Secondary Accessions:
    • A7U7M5
    • Q9H311
    • Q9H312
    • Q9NTM4

    Protein attributes for PRND Gene

    176 amino acids
    Molecular mass:
    20293 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRND Gene

neXtProt entry for PRND Gene

Proteomics data for PRND Gene at MOPED

Post-translational modifications for PRND Gene

  • Glycosylation at Asn 98 and Asn 110

Other Protein References for PRND Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRND Gene

Domains & Families for PRND Gene

Protein Domains for PRND Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prion family.
  • Belongs to the prion family.
genes like me logo Genes that share domains with PRND: view

No data available for Gene Families for PRND Gene

Function for PRND Gene

genes like me logo Genes that share phenotypes with PRND: view

Animal Models for PRND Gene

MGI Knock Outs for PRND:

Animal Model Products

miRNA for PRND Gene

miRTarBase miRNAs that target PRND

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRND Gene

Localization for PRND Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRND Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for PRND Gene COMPARTMENTS Subcellular localization image for PRND gene
Compartment Confidence
extracellular 4
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRND: view

Pathways & Interactions for PRND Gene

SuperPathways for PRND Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRND Gene


No data available for Pathways by source and SIGNOR curated interactions for PRND Gene

Drugs & Compounds for PRND Gene

(2) Drugs for PRND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PRND: view

Transcripts for PRND Gene

mRNA/cDNA for PRND Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRND Gene

Prion protein 2 (dublet):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRND Gene

No ASD Table

Relevant External Links for PRND Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRND Gene

mRNA expression in normal human tissues for PRND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRND Gene

This gene is overexpressed in Testis (x47.7).

Protein differential expression in normal tissues from HIPED for PRND Gene

This gene is overexpressed in Ovary (39.7) and Testis (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRND Gene

SOURCE GeneReport for Unigene cluster for PRND Gene Hs.406696

mRNA Expression by UniProt/SwissProt for PRND Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with PRND: view

Protein tissue co-expression partners for PRND Gene

Primer Products

Orthologs for PRND Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRND Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRND 35
  • 79.92 (n)
  • 77.27 (a)
  • 77 (a)
(Canis familiaris)
Mammalia PRND 35
  • 82.39 (n)
  • 78.98 (a)
  • 78 (a)
(Mus musculus)
Mammalia Prn 35
  • 81.28 (n)
  • 76.54 (a)
Prnd 16
  • 66 (a)
Prnd 36
  • 73 (a)
(Pan troglodytes)
Mammalia PRND 35
  • 98.98 (n)
  • 98.16 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Prnd 35
  • 80.12 (n)
  • 75.16 (a)
(Monodelphis domestica)
Mammalia PRND 36
  • 45 (a)
Species with no ortholog for PRND:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRND Gene

Gene Tree for PRND (if available)
Gene Tree for PRND (if available)

Paralogs for PRND Gene

No data available for Paralogs for PRND Gene

Variants for PRND Gene

Sequence variations from dbSNP and Humsavar for PRND Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_013765 -
rs35453518 - 4,724,718(-) CTCCC(A/G/T)GGCGG reference, missense
rs2245220 - 4,725,072(+) GCTCA(C/T)GGTGA reference, missense
VAR_013769 -
VAR_013770 -

Structural Variations from Database of Genomic Variants (DGV) for PRND Gene

Variant ID Type Subtype PubMed ID
nsv912627 CNV Gain 21882294
nsv179053 CNV Loss 16902084

Variation tolerance for PRND Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRND Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRND Gene

Disorders for PRND Gene

MalaCards: The human disease database

(7) MalaCards diseases for PRND Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
familial creutzfeldt-jakob disease
  • fcjd
prion disease
  • prion disease pathway
sporadic creutzfeldt-jakob disease
  • sporadic cjd
- elite association - COSMIC cancer census association via MalaCards
Search PRND in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRND

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRND Gene

Publications for PRND Gene

  1. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. (PMID: 11702213) Schroeder B. … Zerr I. (Hum. Genet. 2001) 3 4 23 48 67
  2. Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein. (PMID: 19129949) Li P. … Dong X. (Acta Biochim. Biophys. Sin. (Shanghai) 2009) 3 23
  3. [Expression of recombinant human doppel protein and analysis of its cytotoxic activities]. (PMID: 17894227) Li P. … Dong X.P. (Bing Du Xue Bao 2007) 3 23
  4. Spatio-developmental distribution of the prion-like protein doppel in Mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids. (PMID: 16421231) Serres C. … Laplanche J.L. (Biol. Reprod. 2006) 3 23
  5. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients. (PMID: 16889908) Geldermann H. … Zerr I. (Gene 2006) 3 23

Products for PRND Gene

Sources for PRND Gene