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Aliases for PRND Gene

Aliases for PRND Gene

  • Prion Like Protein Doppel 2 3 5
  • Prion-Like Protein Doppel 2 3
  • Prion Protein 2 (Dublet) 2 3
  • PrPLP 3 4
  • DPL 3 4
  • Downstream Prion Protein-Like Gene 2
  • Prion Gene Complex, Downstream 3
  • Downstream Prion Protein-Like 3
  • Prion Protein 2 4
  • DJ1068H6.4 3
  • DOPPEL 3

External Ids for PRND Gene

Previous GeneCards Identifiers for PRND Gene

  • GC20P004690
  • GC20P004697
  • GC20P004650

Summaries for PRND Gene

Entrez Gene Summary for PRND Gene

  • This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRND Gene

PRND (Prion Like Protein Doppel) is a Protein Coding gene. Diseases associated with PRND include Creutzfeldt-Jakob Disease and Prion Disease. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for PRND Gene

  • Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).

Gene Wiki entry for PRND Gene

Additional gene information for PRND Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRND Gene

Genomics for PRND Gene

GeneHancer (GH) Regulatory Elements for PRND Gene

Promoters and enhancers for PRND Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I004719 Enhancer 1.1 Ensembl ENCODE 550.8 -1.3 -1294 1.8 FOXA2 DMAP1 IRF4 ARID2 ZNF207 ZNF143 ATF7 RUNX3 RXRA SP5 PRND PRNP GC20P004699
GH20I004721 Promoter 0.7 EPDnew 550.8 +0.0 37 0.1 GLIS1 ZIC2 PRND LOC100421361
GH20I004684 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 -34.9 -34900 5.5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF213 PRNP PRND LOC100421361 PRNT GC20P004700
GH20I004949 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +229.1 229084 2.4 HDGF CTCF JUN CEBPG RAD21 YY1 LCORL HSF1 HNF4G FOSL2 SLC23A2 LOC100421361 PRNT RASSF2 ENSG00000252096 PRNP PRND LINC00658 GC20M004944 GC20P004944
GH20I004961 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +240.2 240160 1.6 ATF1 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 SLC30A9 ATF7 RASSF2 LOC100421361 PRNT TMEM230 PRND CDS2 SLC23A2 GC20M004944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRND on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRND gene promoter:

Genomic Locations for PRND Gene

Genomic Locations for PRND Gene
chr20:4,721,854-4,728,462
(GRCh38/hg38)
Size:
6,609 bases
Orientation:
Plus strand
chr20:4,702,556-4,709,106
(GRCh37/hg19)

Genomic View for PRND Gene

Genes around PRND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRND Gene

Proteins for PRND Gene

  • Protein details for PRND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKY0-PRND_HUMAN
    Recommended name:
    Prion-like protein doppel
    Protein Accession:
    Q9UKY0
    Secondary Accessions:
    • A7U7M5
    • Q9H311
    • Q9H312
    • Q9NTM4

    Protein attributes for PRND Gene

    Size:
    176 amino acids
    Molecular mass:
    20293 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRND Gene

neXtProt entry for PRND Gene

Post-translational modifications for PRND Gene

Other Protein References for PRND Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRND Gene

Domains & Families for PRND Gene

Gene Families for PRND Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for PRND Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKY0

UniProtKB/Swiss-Prot:

PRND_HUMAN :
  • A short helical region is required and sufficient for Cu(2+) binding.
  • Belongs to the prion family.
Domain:
  • A short helical region is required and sufficient for Cu(2+) binding.
Family:
  • Belongs to the prion family.
genes like me logo Genes that share domains with PRND: view

Function for PRND Gene

Molecular function for PRND Gene

UniProtKB/Swiss-Prot Function:
Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).

Phenotypes From GWAS Catalog for PRND Gene

Gene Ontology (GO) - Molecular Function for PRND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IDA 20411530
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRND: view
genes like me logo Genes that share phenotypes with PRND: view

Animal Models for PRND Gene

MGI Knock Outs for PRND:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRND Gene

Localization for PRND Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRND Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRND gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane ISS --
genes like me logo Genes that share ontologies with PRND: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRND Gene

Pathways & Interactions for PRND Gene

genes like me logo Genes that share pathways with PRND: view

Interacting Proteins for PRND Gene

Gene Ontology (GO) - Biological Process for PRND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006878 cellular copper ion homeostasis IBA --
GO:0007338 single fertilization IEA --
GO:0007340 acrosome reaction ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with PRND: view

No data available for SIGNOR curated interactions for PRND Gene

Drugs & Compounds for PRND Gene

(2) Drugs for PRND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PRND: view

Transcripts for PRND Gene

mRNA/cDNA for PRND Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRND Gene

Prion protein 2 (dublet):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRND Gene

No ASD Table

Relevant External Links for PRND Gene

GeneLoc Exon Structure for
PRND
ECgene alternative splicing isoforms for
PRND

Expression for PRND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRND Gene

This gene is overexpressed in Testis (x47.7).

Protein differential expression in normal tissues from HIPED for PRND Gene

This gene is overexpressed in Ovary (39.7) and Testis (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRND Gene



Protein tissue co-expression partners for PRND Gene

NURSA nuclear receptor signaling pathways regulating expression of PRND Gene:

PRND

SOURCE GeneReport for Unigene cluster for PRND Gene:

Hs.406696

mRNA Expression by UniProt/SwissProt for PRND Gene:

Q9UKY0-PRND_HUMAN
Tissue specificity: Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).

Evidence on tissue expression from TISSUES for PRND Gene

  • Nervous system(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with PRND: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRND Gene

Orthologs for PRND Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRND Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRND 34 33
  • 98.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRND 33 34
  • 82.39 (n)
mouse
(Mus musculus)
Mammalia Prnd 33 16 34
  • 81.28 (n)
PRND 34
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prnd 33
  • 80.12 (n)
cow
(Bos Taurus)
Mammalia PRND 33 34
  • 79.92 (n)
oppossum
(Monodelphis domestica)
Mammalia PRND 34
  • 45 (a)
OneToOne
Species where no ortholog for PRND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRND Gene

ENSEMBL:
Gene Tree for PRND (if available)
TreeFam:
Gene Tree for PRND (if available)

Paralogs for PRND Gene

No data available for Paralogs for PRND Gene

Variants for PRND Gene

Sequence variations from dbSNP and Humsavar for PRND Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000452062 -- 4,722,105(+) A/T intron_variant
rs1000514564 -- 4,721,946(+) A/C 5_prime_UTR_variant
rs1000759653 -- 4,726,928(+) G/A 3_prime_UTR_variant
rs1001139187 -- 4,723,955(+) T/G intron_variant
rs1001379302 -- 4,724,281(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRND Gene

Variant ID Type Subtype PubMed ID
esv3645074 CNV gain 21293372
nsv1058830 CNV gain 25217958
nsv179053 CNV deletion 16902084
nsv585310 CNV gain 21841781

Variation tolerance for PRND Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRND Gene

Human Gene Mutation Database (HGMD)
PRND
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRND

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRND Gene

Disorders for PRND Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRND Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
creutzfeldt-jakob disease
  • cjd
prion disease
  • prion disease pathway
scrapie
astrocytoma
  • astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search PRND in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRND

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRND Gene

Publications for PRND Gene

  1. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. (PMID: 11702213) Schröder B … Zerr I (Human genetics 2001) 3 4 22 44 58
  2. Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients. (PMID: 16889908) Geldermann H … Zerr I (Gene 2006) 3 22 44 58
  3. Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study. (PMID: 17047093) Vollmert C … Kretzschmar HA (Journal of medical genetics 2006) 3 22 44 58
  4. Polymorphisms at codons 56 and 174 of the prion-like protein gene (PRND) are not associated with sporadic Creutzfeldt-Jakob disease. (PMID: 15933804) Jeong BH … Kim YS (Journal of human genetics 2005) 3 22 44 58
  5. Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease. (PMID: 15986038) Jeong BH … Kim YS (European journal of human genetics : EJHG 2005) 3 22 44 58

Products for PRND Gene

Sources for PRND Gene

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