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Aliases for PRMT8 Gene

Aliases for PRMT8 Gene

  • Protein Arginine Methyltransferase 8 2 3
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 4 3 4
  • HRMT1L3 3 4
  • HRMT1L4 3 4
  • HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 4 (S. Cerevisiae) 2
  • Protein Arginine N-Methyltransferase 4 3
  • Protein Arginine N-Methyltransferase 8 3
  • HMT1 HnRNP Methyltransferase-Like 3 3
  • EC 2.1.1.77 64
  • EC 2.1.1.- 4
  • EC 2.1.1 64

External Ids for PRMT8 Gene

Previous Symbols for PRMT8 Gene

  • HRMT1L3
  • HRMT1L4

Summaries for PRMT8 Gene

Entrez Gene Summary for PRMT8 Gene

  • Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRMT8 Gene

PRMT8 (Protein Arginine Methyltransferase 8) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for PRMT8 Gene

  • Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT8 Gene

Genomics for PRMT8 Gene

Genomic Location for PRMT8 Gene

Start:
3,381,349 bp from pter
End:
3,593,973 bp from pter
Size:
212,625 bases
Orientation:
Plus strand

Genomic View for PRMT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRMT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT8 Gene

Regulatory Elements for PRMT8 Gene

Proteins for PRMT8 Gene

  • Protein details for PRMT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR22-ANM8_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 8
    Protein Accession:
    Q9NR22
    Secondary Accessions:
    • B2RDP0
    • Q8TBJ8

    Protein attributes for PRMT8 Gene

    Size:
    394 amino acids
    Molecular mass:
    45291 Da
    Quaternary structure:
    • Homodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with PRMT2 and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status.
    SequenceCaution:
    • Sequence=AAF91390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37987.1; Type=Frameshift; Positions=45; Evidence={ECO:0000305};

    Alternative splice isoforms for PRMT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT8 Gene

Proteomics data for PRMT8 Gene at MOPED

Selected DME Specific Peptides for PRMT8 Gene

Post-translational modifications for PRMT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRMT8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PRMT8 Gene

Gene Families for PRMT8 Gene

HGNC:
  • PRMT :Protein arginine methyltransferases
IUPHAR :

Protein Domains for PRMT8 Gene

UniProtKB/Swiss-Prot:

ANM8_HUMAN
Domain:
  • The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.:
    • Q9NR22
  • The N-terminal region (1-60) inhibits the enzymatic activity.:
    • Q9NR22
  • Contains 1 SAM-dependent MTase PRMT-type domain.:
    • Q9NR22
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily.:
    • Q9NR22
genes like me logo Genes that share domains with PRMT8: view

Function for PRMT8 Gene

Molecular function for PRMT8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.3 uM for GRGGFGGRGGFRGGRGG-NH2 {ECO:0000269 PubMed:18320585};
UniProtKB/Swiss-Prot Function: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.

Enzyme Numbers (IUBMB) for PRMT8 Gene

Gene Ontology (GO) - Molecular Function for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16051612
GO:0008168 methyltransferase activity --
GO:0008276 protein methyltransferase activity --
GO:0008469 histone-arginine N-methyltransferase activity IDA 16051612
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 16051612
genes like me logo Genes that share ontologies with PRMT8: view
genes like me logo Genes that share phenotypes with PRMT8: view

miRNA for PRMT8 Gene

miRTarBase miRNAs that target PRMT8

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRMT8 Gene

Localization for PRMT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT8 Gene COMPARTMENTS Subcellular localization image for PRMT8 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 16051612
GO:0005737 cytoplasm --
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IDA 16051612
genes like me logo Genes that share ontologies with PRMT8: view

Pathways for PRMT8 Gene

SuperPathways for PRMT8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006479 protein methylation --
GO:0008152 metabolic process --
GO:0016571 histone methylation IDA 16051612
GO:0018216 peptidyl-arginine methylation IDA 16051612
genes like me logo Genes that share ontologies with PRMT8: view

No data available for Pathways by source for PRMT8 Gene

Transcripts for PRMT8 Gene

Unigene Clusters for PRMT8 Gene

Protein arginine methyltransferase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for PRMT8 Gene

GeneLoc Exon Structure for
PRMT8
ECgene alternative splicing isoforms for
PRMT8

Expression for PRMT8 Gene

mRNA expression in normal human tissues for PRMT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRMT8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.2), Brain - Putamen (basal ganglia) (6.9), Brain - Cortex (6.6), Brain - Caudate (basal ganglia) (6.2), Brain - Frontal Cortex (BA9) (6.0), and Brain - Anterior cingulate cortex (BA24) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRMT8 Gene

SOURCE GeneReport for Unigene cluster for PRMT8 Gene Hs.504530

mRNA Expression by UniProt/SwissProt for PRMT8 Gene

Q9NR22-ANM8_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expressions with PRMT8: view

Orthologs for PRMT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT8 36
  • 99.32 (n)
  • 99.75 (a)
PRMT8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRMT8 36
  • 92.89 (n)
  • 98.98 (a)
PRMT8 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT8 36
  • 94.75 (n)
  • 98.48 (a)
PRMT8 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt8 36
  • 93.06 (n)
  • 98.48 (a)
Prmt8 16
Prmt8 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRMT8 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT8 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prmt8 36
  • 92.98 (n)
  • 98.48 (a)
chicken
(Gallus gallus)
Aves PRMT8 36
  • 82.15 (n)
  • 94.16 (a)
PRMT8 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT8 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt8 36
  • 79 (n)
  • 90.31 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01016567.1 37
  • 81 (a)
OneToMany
LOC556054 36
  • 77.07 (n)
  • 85.28 (a)
prmt8b 37
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Art1 37
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prmt-1 37
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 37
  • 46 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.1977 36
corn
(Zea mays)
Liliopsida Zm.2042 36
rice
(Oryza sativa)
Liliopsida Os.18453 36
wheat
(Triticum aestivum)
Liliopsida Ta.385 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4364 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2169 37
  • 68 (a)
OneToMany
Species with no ortholog for PRMT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRMT8 Gene

ENSEMBL:
Gene Tree for PRMT8 (if available)
TreeFam:
Gene Tree for PRMT8 (if available)

Paralogs for PRMT8 Gene

Paralogs for PRMT8 Gene

Selected SIMAP similar genes for PRMT8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRMT8: view

Variants for PRMT8 Gene

Sequence variations from dbSNP and Humsavar for PRMT8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs731577 -- 3,518,835(-) tttaa(C/T)cctga intron-variant
rs740765 -- 3,433,937(+) GTTGC(A/G)TGAAA intron-variant
rs758611 -- 3,518,427(-) TTTCC(A/G)AGAGT intron-variant
rs758612 -- 3,518,285(-) AGGAA(G/T)AGGGA intron-variant
rs758613 -- 3,470,980(-) CCAGG(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT8 Gene

Variant ID Type Subtype PubMed ID
nsv581 CNV Loss 18451855
esv2745435 CNV Deletion 23290073
esv2293557 CNV Deletion 18987734
esv3874 CNV Deletion 18987735
esv2745436 CNV Deletion 23290073
nsv468980 CNV Loss 19166990
nsv468981 CNV Gain 19166990

Relevant External Links for PRMT8 Gene

HapMap Linkage Disequilibrium report
PRMT8

Disorders for PRMT8 Gene

(1) University of Copenhagen DISEASES for PRMT8 Gene

Relevant External Links for PRMT8

Genetic Association Database (GAD)
PRMT8
Human Genome Epidemiology (HuGE) Navigator
PRMT8
genes like me logo Genes that share disorders with PRMT8: view

No data available for UniProtKB/Swiss-Prot for PRMT8 Gene

Publications for PRMT8 Gene

  1. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. (PMID: 17925405) Sayegh J. … Clarke S.G. (J. Biol. Chem. 2007) 3 4 23
  2. Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. (PMID: 18320585) Pahlich S. … Gehring H. (Proteins 2008) 3 4 23
  3. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PMID: 16051612) Lee J. … Bedford M.T. (J. Biol. Chem. 2005) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PRMT8 Gene

Sources for PRMT8 Gene

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