Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRMT8 Gene

protein-coding   GIFtS: 54
GCID: GC12P003490

protein arginine methyltransferase 8

(Previous names: HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae), HMT1...)
(Previous symbols: HRMT1L3, HRMT1L4)
 Explore 7 diseases affiliated with
PRMT8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRMT8    

Aliases
for PRMT8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Arginine Methyltransferase 81 2     HMT1 HnRNP Methyltransferase-Like 32
HRMT1L31 2 3     Protein Arginine N-Methyltransferase 42
HRMT1L41 2 3     Protein Arginine N-Methyltransferase 82
Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 42 3     EC 2.1.1.-3
HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae)1     EC 2.1.18
HMT1 HnRNP Methyltransferase-Like 4 (S. Cerevisiae)1     EC 2.1.1.778

External Ids:    HGNC: 51881   Entrez Gene: 563412   Ensembl: ENSG000001112187   OMIM: 6100865   UniProtKB: Q9NR223   

Export aliases for PRMT8 gene to outside databases

Previous GC identifers: GC12P003470 GC12P003600


Summaries
for PRMT8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRMT8:
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as
PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription,
signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 (PubMed
16051612)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
Function: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N
monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however
its precise role toward EWS remains unclear as it still interacts with fully methylated EWS




Genomic Views
for PRMT8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRMT8 gene promoter:
         AhR   MAZR   Pax-6   YY1   Arnt   E47   HEN1   Pax-3   E2F   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRMT8 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRMT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13.3

PRMT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P003490:  view genomic region     (about GC identifiers)

Start:
 3,490,515 bp from pter      End:
 3,703,139 bp from pter
Size:
 212,625 bases      Orientation:
 plus strand

Proteins
for PRMT8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 8  
Size: 394 amino acids; 45291 Da
Subunit: Homodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with PRMT2
and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Sequence caution: Sequence=AAF91390.1; Type=Erroneous initiation; Sequence=BAG37987.1; Type=Frameshift; Positions=45;
Secondary accessions: B2RDP0 Q8TBJ8
Alternative splicing: 2 isoforms:  Q9NR22-1   Q9NR22-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT8: NX_Q9NR22

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NR22

    • 4/10 DME Specific Peptides for PRMT8 (Q9NR22) (see all 10)
     KVVLDVG  DYYFDSY  HEEMLKD  KWLKPGG 

    PRMT8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243465.1  NP_062828.3  

    ENSEMBL proteins: 
     ENSP00000414507   ENSP00000372067  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PRMT8
    OriGene Protein Over-expression Lysate: PRMT8
    OriGene Custom Protein Services for PRMT8 
    GenScript Custom Purified and Recombinant Proteins Services for PRMT8
    Novus Biologicals PRMT8 Proteins
    Novus Biologicals PRMT8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRMT8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA16051612
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA16051612


    PRMT8 for ontologies           About GeneDecksing



    PRMT8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: PRMT8
    OriGene Custom Antibody Services for PRMT8 
    GenScript Custom Superior Antibodies Services for PRMT8
    Novus Biologicals PRMT8 Antibodies
    Search for Antibodies for PRMT8 at Abcam  
    Uscn Antibodies for PRMT8
    ThermoFisher Antibodies for PRMT8

    Assay Products for PRMT8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRMT8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRMT8

    Protein Domains /
    Families
    for PRMT8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRMT8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA

    Graphical View of Domain Structure for InterPro Entry Q9NR22

    ProtoNet protein and cluster: Q9NR22

    UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
    Domain: The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN,
    possibly leading to displace the N-terminal domain and activate the protein
    Domain: The N-terminal region (1-60) inhibits the enzymatic activity
    Similarity: Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily


    Function
    for PRMT8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
    Function: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N
    monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however
    its precise role toward EWS remains unclear as it still interacts with fully methylated EWS
    Biophysicochemical properties: Kinetic parameters: KM=1.3 uM for GRGGFGGRGGFRGGRGG-NH2;

    Enzyme Numbers (IUBMB): EC 2.1.1.772 EC 2.1.1.-1 EC 2.1.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PRMT8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRMT8
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate PRMT8 (see all 12):
    hsa-miR-3173-3p hsa-miR-676 hsa-miR-7-2* hsa-miR-27a hsa-miR-548o hsa-miR-103a hsa-miR-339-3p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: PRMT8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRMT8 (see all 4)
    OriGene shRNA RFP: PRMT8
    OriGene siRNA: PRMT8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRMT8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRMT8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRMT8 (NM_019854)
    Sino Biological Human cDNA Clone for PRMT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRMT8
    Search LifeMap BioReagents cell lines for PRMT8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT8

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16051612
    GO:0008469histone-arginine N-methyltransferase activity IDA16051612
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA16051612
    GO:0035241protein-arginine omega-N monomethyltransferase activity IDA16051612
    GO:0035242protein-arginine omega-N asymmetric methyltransferase activity IDA18320585


    PRMT8 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PRMT8:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Prmt8):
     immune system 

    PRMT8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRMT8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRMT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for PRMT8 (Q9NR221, 3 ENSP000003720674) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384323, ENSP000002403164I2D: score=2 STRING: ENSP00000240316
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    SYNCRIPO605063, ENSP000003586354I2D: score=1 STRING: ENSP00000358635
    PRMT1Q998733I2D: score=1 
    PRMT8Q9NR221EBI-745545,EBI-745545
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016571histone methylation IDA16051612
    GO:0018216peptidyl-arginine methylation IDA16051612
    GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA16051612
    GO:0034969histone arginine methylation IDA16051612
    GO:0043393regulation of protein binding TAS16051612


    PRMT8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRMT8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PRMT8:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRMT8
    Search CenterWatch for drugs/clinical trials and news about PRMT8 / ANM8 

    Transcripts
    for PRMT8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRMT8 gene (3 alternative transcripts): 
    NM_001256537.1  NM_001256536.1  NM_019854.4  

    Unigene Cluster for PRMT8:

    Protein arginine methyltransferase 8
    Hs.504530  [show with all ESTs]
    Unigene Representative Sequence: AK026786
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452611 ENST00000382622(uc009zed.3 uc001qmf.3 uc001qmg.3 uc001qmh.3)
    ENST00000543701 ENST00000261252(uc009zee.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PRMT8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRMT8
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate PRMT8 (see all 12):
    hsa-miR-3173-3p hsa-miR-676 hsa-miR-7-2* hsa-miR-27a hsa-miR-548o hsa-miR-103a hsa-miR-339-3p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: PRMT8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRMT8 (see all 4)
    OriGene shRNA RFP: PRMT8
    OriGene siRNA: PRMT8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRMT8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRMT8 (NM_019854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRMT8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRMT8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRMT8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT8

    Additional cDNA sequence: 

    AF263539.1 AK026786.1 AK093651.1 AK315619.1 BC022458.1 

    3 DOTS entries:

    DT.91750857  DT.121129050  DT.100017281 

    24/25 AceView cDNA sequences (see all 25):

    AA776911 BM921694 AA861463 AW088060 BG149561 AF263539 BX098641 NM_019854 
    BC022458 BM805285 BF433361 AK093651 BM975204 AI150403 AI368503 BM547924 
    AK026786 BF953462 CD687488 BG714739 BE327021 AI927209 BI489941 BF528491 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -                             -                     
    SP2:              -           -                 -                                 
    SP3:                                            -                                 


    ECgene alternative splicing isoforms for PRMT8

    Expression
    for PRMT8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRMT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAACAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRMT8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    CartilageLumbar Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRMT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRMT8

    SOURCE GeneReport for Unigene cluster: Hs.504530

    UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
    Tissue specificity: Brain-specific

        SABiosciences Expression via Pathway-Focused PCR Array including PRMT8: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRMT8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRMT8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRMT8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT8

    Orthologs
    for PRMT8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT8 gene from 7/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRMT81 protein arginine methyltransferase 8 82.15(n)
    94.16(a)    		   425989  XM_423669.3  XP_423669.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PRMT86
    		 --
    		 90(a)
    		 1 ↔ 1
    		 5(81450680-81489212)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5560541 protein arginine N-methyltransferase 8-B-like 77.07(n)
    85.28(a)    		   556054  XM_003200433.1  XP_003200481.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Art16
    Art66
    (see all 5)    		 Arginine methyltransferase 6
    (see all 5)    		 61(a)
    38(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 3R(6612203-6613946)
    3R(9770376-9771534)
    worm
    (Caenorhabditis elegans)    		 Secernentea prmt-16
    		 Protein PRMT-1
    		 64(a)
    		 1 → many
    		 V(20267338-20269682)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATPRMT1A6
    ATPRMT116
    		 protein arginine N-methyltransferase 1
    		 52(a)
    49(a)
    		 many ↔ many
    many ↔ many
    		 2(8499086-8501181)
    4(14491625-14494001)
    rice
    (Oryza sativa)    		 Liliopsida Os.184532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.97(n)    AK099826.1 


    ENSEMBL Gene Tree for PRMT8 (if available)
    TreeFam Gene Tree for PRMT8 (if available) 

    Paralogs
    for PRMT8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRMT8 gene
    PRMT62  PRMT32  CARM12  PRMT22  PRMT12  
    6 SIMAP similar genes for PRMT8 using alignment to 2 protein entries:     ANM8_HUMAN (see all proteins):
    PRMT1    PRMT3    HRMT1L2    PRMT2    PRMT6    CARM1

    PRMT8 for paralogs           About GeneDecksing



    Genomic Variants
    for PRMT8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3633 NCBI SNPs in PRMT8 are shown (see all 3633)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs779880701,2
    		C,,--3448559(+) TTTTTC/TCTGTG 1 -- ds50010--------
    rs732600811,2
    		C,--3448617(+) GAGAGG/CTACGC 1 -- ds50013Minor allele frequency- C:0.15WA NA 240
    rs1116544031,2
    		C,--3449258(+) GGAAGG/AAGGGG 1 -- nc-transcript-variant1Minor allele frequency- A:0.50NA 2
    rs79745761,2
    		C,F,H,--3449303(+) GAGTTG/AAATTT 1 -- nc-transcript-variant15Minor allele frequency- A:0.10NS EA NA WA 1892
    rs79647491,2
    		C,F,H,--3449356(+) GTGGTT/GAGCAT 1 -- nc-transcript-variant15Minor allele frequency- G:0.11NS EA NA WA 1890
    rs79746821,2
    		C,F,A,H,--3449406(+) GATGCG/AGGGTT 1 -- nc-transcript-variant17Minor allele frequency- A:0.09NS EA NA WA 2032
    rs795043961,2
    		F,--3449884(+) GGGAGG/ATTTTA 1 -- nc-transcript-variant1Minor allele frequency- A:0.02NA 120
    rs785230641,2
    		F,--3450511(+) AATTTC/GATGAG 1 -- nc-transcript-variant1Minor allele frequency- G:0.04WA 118
    rs110626801,2
    		C,F,A,H,--3450542(+) GGTAAT/CATCAC 1 -- nc-transcript-variant3Minor allele frequency- C:0.07NA WA 124
    rs110626811,2
    		C,F,A,H,--3450606(+) TAAAAC/TTCATT 1 -- nc-transcript-variant10Minor allele frequency- T:0.04NS EA NA 1190

    HapMap Linkage Disequilibrium report for PRMT8 (3490515 - 3703139 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PRMT8
         2 Indels: 41649 45042

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRMT8
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT8

    Disorders / Diseases
    for PRMT8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRMT8 for disorders           About GeneDecksing

    OMIM gene information: 610086    OMIM disorders: --

    7 diseases for PRMT8:    About MalaCards
    primitive neuroectodermal tumor    peripheral primitive neuroectodermal tumor    neuroectodermal tumors    coronary heart disease
    ataxia    sarcoma    malaria

    1 disease from the University of Copenhagen DISEASES database for PRMT8:
    Peripheral primitive neuroectodermal tumor
    Human Genome Epidemiology (HuGE) Navigator: PRMT8 (2 documents)

    Export disorders for PRMT8 gene to outside databases

    Publications
    for PRMT8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRMT8 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PRMT8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PubMed id 16051612)1, 2, 3 Lee J....Bedford M.T. (2005)
    2. Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. (PubMed id 18320585)1, 2, 9 Pahlich S.... Gehring H. (2008)
    3. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. (PubMed id 17925405)1, 2, 9 Sayegh J....Clarke S.G. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Protein arginine methyltransferase 1-directed methylat ion of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. (PubMed id 22179613)1 Campbell M....Izumiya Y. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    10. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1 Aulchenko Y.S....Peltonen L. (2009)

    External Searches for PRMT8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRMT8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56341 HGNC: 5188 AceView: HRMT1L4 Ensembl:ENSG00000111218 euGenes: HUgn56341
    ECgene: PRMT8 H-InvDB: PRMT8

    Other Databases showing PRMT8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRMT8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRMT8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRMT8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRMT8 gene:
    Search GeneIP for patents involving PRMT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRMT8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for PRMT8
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for PRMT8   OriGene shRNA RFP for PRMT8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRMT8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRMT8  
     OriGene Protein Over-expression Lysate for PRMT8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PRMT8   OriGene 3'-UTR Clone for PRMT8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PRMT8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRMT8   OriGene Custom Protein Services for PRMT8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRMT8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRMT8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRMT8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRMT8
     GenScript Custom Purified and Recombinant Proteins Services for PRMT8 GenScript cDNA clones with any tag delivered in your preferred vector for PRMT8
     GenScript Custom Assay Services for PRMT8 GenScript Custom Superior Antibodies Services for PRMT8
     GenScript Custom overexpressing Cell Line Services for PRMT8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRMT8 promoter
     Search Chromatin IP Primers for PRMT8
     RT2 qPCR Primer Assay in human, mouse, rat PRMT8
     Search GNC Networks for PRMT8
     SABiosciences PCR Arrays including human, mouse, rat PRMT8
     Search Tocris compounds for PRMT8
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for PRMT8
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRMT8 antibodies
     PRMT8 proteins
     PRMT8 lysates
     Search for Antibodies for PRMT8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PRMT8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PRMT8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PRMT8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT8
     SwitchGear 3'UTR luciferase reporter plasmids for PRMT8
     SwitchGear Promoter luciferase reporter plasmids for PRMT8
     ThermoFisher Antibodies for PRMT8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PRMT8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4