Aliases for PRMT8 Gene
External Ids for PRMT8 Gene
Previous HGNC Symbols for PRMT8 Gene
Previous GeneCards Identifiers for PRMT8 Gene
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PRMT8 Gene
PRMT8 (Protein Arginine Methyltransferase 8) is a Protein Coding gene. Diseases associated with PRMT8 include ewing sarcoma. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PRMT6.
UniProtKB/Swiss-Prot for PRMT8 Gene
Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.