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Aliases for PRMT8 Gene

Aliases for PRMT8 Gene

  • Protein Arginine Methyltransferase 8 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 4 3 4
  • HRMT1L3 3 4
  • HRMT1L4 3 4
  • HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 4 (S. Cerevisiae) 2
  • Protein Arginine N-Methyltransferase 4 3
  • Protein Arginine N-Methyltransferase 8 3
  • HMT1 HnRNP Methyltransferase-Like 3 3
  • Arginine Methyltransferase 8 3
  • EC 2.1.1.77 61
  • EC 2.1.1.- 4
  • EC 2.1.1 61

External Ids for PRMT8 Gene

Previous HGNC Symbols for PRMT8 Gene

  • HRMT1L3
  • HRMT1L4

Previous GeneCards Identifiers for PRMT8 Gene

  • GC12P003470
  • GC12P003600
  • GC12P003490

Summaries for PRMT8 Gene

Entrez Gene Summary for PRMT8 Gene

  • Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRMT8 Gene

PRMT8 (Protein Arginine Methyltransferase 8) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is PRMT1.

UniProtKB/Swiss-Prot for PRMT8 Gene

  • Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.

Tocris Summary for PRMT8 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT8 Gene

Genomics for PRMT8 Gene

Regulatory Elements for PRMT8 Gene

Enhancers for PRMT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F003310 0.9 FANTOM5 ENCODE 3.3 -69.9 -69866 1.8 ZFHX2 MAZ ZNF687 FOS ZIC2 TCF7L2 PRMT8 LOC105369606 GC12M003283
GH12F003380 0.6 ENCODE 0.8 -0.2 -189 1.4 GLIS2 KLF1 JUND SUZ12 GLIS1 CEBPB FOXP2 MAFK EZH2 PRMT8 LOC101930162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRMT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRMT8 Gene

Chromosome:
12
Start:
3,381,349 bp from pter
End:
3,593,973 bp from pter
Size:
212,625 bases
Orientation:
Plus strand

Genomic View for PRMT8 Gene

Genes around PRMT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT8 Gene

Proteins for PRMT8 Gene

  • Protein details for PRMT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR22-ANM8_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 8
    Protein Accession:
    Q9NR22
    Secondary Accessions:
    • B2RDP0
    • Q8TBJ8

    Protein attributes for PRMT8 Gene

    Size:
    394 amino acids
    Molecular mass:
    45291 Da
    Quaternary structure:
    • Homodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with PRMT2 and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status.
    SequenceCaution:
    • Sequence=AAF91390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37987.1; Type=Frameshift; Positions=45; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT8 Gene

    Alternative splice isoforms for PRMT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT8 Gene

Selected DME Specific Peptides for PRMT8 Gene

Q9NR22:
  • HEEMLKD
  • KWLKPGG
  • LDFKGQLC
  • VTNACLIKEVDIYTVK
  • IISEWMGY
  • VLDVGSG
  • DYYFDSY
  • GIHEEML
  • KVVLDVG
  • AKAGAKKV

Post-translational modifications for PRMT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRMT8 Gene

Domains & Families for PRMT8 Gene

Gene Families for PRMT8 Gene

Protein Domains for PRMT8 Gene

Suggested Antigen Peptide Sequences for PRMT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR22

UniProtKB/Swiss-Prot:

ANM8_HUMAN :
  • The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily.
Domain:
  • The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.
  • The N-terminal region (1-60) inhibits the enzymatic activity.
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily.
genes like me logo Genes that share domains with PRMT8: view

Function for PRMT8 Gene

Molecular function for PRMT8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.3 uM for GRGGFGGRGGFRGGRGG-NH2 {ECO:0000269 PubMed:18320585};
UniProtKB/Swiss-Prot Function:
Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.

Enzyme Numbers (IUBMB) for PRMT8 Gene

Gene Ontology (GO) - Molecular Function for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16051612
GO:0008168 methyltransferase activity IEA --
GO:0008469 histone-arginine N-methyltransferase activity IDA 16051612
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 16051612
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PRMT8: view
genes like me logo Genes that share phenotypes with PRMT8: view

Animal Models for PRMT8 Gene

MGI Knock Outs for PRMT8:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT8 Gene

Localization for PRMT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT8 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT8 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 16051612
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IEA,IDA 16051612
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRMT8: view

Pathways & Interactions for PRMT8 Gene

SuperPathways for PRMT8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRMT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006479 protein methylation IEA --
GO:0016571 histone methylation IDA 16051612
GO:0018216 peptidyl-arginine methylation IDA 16051612
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA 16051612
genes like me logo Genes that share ontologies with PRMT8: view

No data available for Pathways by source and SIGNOR curated interactions for PRMT8 Gene

Transcripts for PRMT8 Gene

Unigene Clusters for PRMT8 Gene

Protein arginine methyltransferase 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for PRMT8 Gene

GeneLoc Exon Structure for
PRMT8
ECgene alternative splicing isoforms for
PRMT8

Expression for PRMT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRMT8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.2), Brain - Putamen (basal ganglia) (x6.9), Brain - Cortex (x6.6), Brain - Caudate (basal ganglia) (x6.2), Brain - Frontal Cortex (BA9) (x6.0), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for PRMT8 Gene

This gene is overexpressed in Frontal cortex (61.6) and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRMT8 Gene



Protein tissue co-expression partners for PRMT8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRMT8 Gene:

PRMT8

SOURCE GeneReport for Unigene cluster for PRMT8 Gene:

Hs.504530

mRNA Expression by UniProt/SwissProt for PRMT8 Gene:

Q9NR22-ANM8_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with PRMT8: view

Primer Products

Orthologs for PRMT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT8 34 35
  • 99.32 (n)
oppossum
(Monodelphis domestica)
Mammalia PRMT8 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT8 34 35
  • 94.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT8 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt8 34 16 35
  • 93.06 (n)
rat
(Rattus norvegicus)
Mammalia Prmt8 34
  • 92.98 (n)
cow
(Bos Taurus)
Mammalia PRMT8 34 35
  • 92.89 (n)
chicken
(Gallus gallus)
Aves PRMT8 34 35
  • 82.15 (n)
lizard
(Anolis carolinensis)
Reptilia PRMT8 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt8 34
  • 79 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01016567.1 35
  • 81 (a)
OneToMany
prmt8b 35
  • 79 (a)
OneToMany
LOC556054 34
  • 77.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Art1 35
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prmt-1 35
  • 65 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 35
  • 46 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.1977 34
rice
(Oryza sativa)
Liliopsida Os.18453 34
wheat
(Triticum aestivum)
Liliopsida Ta.385 34
corn
(Zea mays)
Liliopsida Zm.2042 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2169 35
  • 68 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4364 34
Species where no ortholog for PRMT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRMT8 Gene

ENSEMBL:
Gene Tree for PRMT8 (if available)
TreeFam:
Gene Tree for PRMT8 (if available)

Paralogs for PRMT8 Gene

Paralogs for PRMT8 Gene

(6) SIMAP similar genes for PRMT8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRMT8: view

Variants for PRMT8 Gene

Sequence variations from dbSNP and Humsavar for PRMT8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082841 -- 3,401,994(+) TCATA(C/T)GGAAC intron-variant
rs1014132 -- 3,384,963(-) CCCCC(A/G)CCCCC intron-variant
rs1029766 -- 3,594,334(-) AAACA(C/T)TCCAC downstream-variant-500B
rs10444476 -- 3,388,041(+) ccttc(C/T)ttcct intron-variant
rs10450713 -- 3,447,795(+) GTGTT(C/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT8 Gene

Variant ID Type Subtype PubMed ID
nsv976557 CNV duplication 23825009
nsv581 CNV deletion 18451855
nsv580 CNV insertion 18451855
nsv557116 CNV gain 21841781
nsv557115 CNV loss 21841781
nsv483060 CNV loss 15286789
nsv468981 CNV gain 19166990
nsv468980 CNV loss 19166990
nsv1150557 CNV deletion 26484159
nsv1112253 CNV deletion 24896259
nsv1071003 CNV deletion 25765185
nsv1042348 CNV gain 25217958
esv3874 CNV loss 18987735
esv3628346 CNV loss 21293372
esv3628345 CNV loss 21293372
esv28881 CNV loss 19812545
esv2745436 CNV deletion 23290073
esv2745435 CNV deletion 23290073
esv2674403 CNV deletion 23128226
esv2293557 CNV deletion 18987734
dgv245e214 CNV gain 21293372

Variation tolerance for PRMT8 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT8 Gene

Disorders for PRMT8 Gene

Relevant External Links for PRMT8

Genetic Association Database (GAD)
PRMT8
Human Genome Epidemiology (HuGE) Navigator
PRMT8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT8

No disorders were found for PRMT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRMT8 Gene

Publications for PRMT8 Gene

  1. Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. (PMID: 18320585) Pahlich S. … Gehring H. (Proteins 2008) 3 4 22 64
  2. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. (PMID: 17925405) Sayegh J. … Clarke S.G. (J. Biol. Chem. 2007) 3 4 22 64
  3. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PMID: 16051612) Lee J. … Bedford M.T. (J. Biol. Chem. 2005) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko Y.S. … Peltonen L. (Nat. Genet. 2009) 3 46 64

Products for PRMT8 Gene

Sources for PRMT8 Gene

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