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PRMT8 Gene

protein-coding   GIFtS: 56
GCID: GC12P003490

Protein Arginine Methyltransferase 8

(Previous names: HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae), HMT1...)
(Previous symbols: HRMT1L3, HRMT1L4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 81 2     HMT1 HnRNP Methyltransferase-Like 32
HRMT1L31 2 3     Protein Arginine N-Methyltransferase 42
HRMT1L41 2 3     Protein Arginine N-Methyltransferase 82
Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 42 3     EC 2.1.1.-3
HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae)1     EC 2.1.18
HMT1 HnRNP Methyltransferase-Like 4 (S. Cerevisiae)1     EC 2.1.1.778

External Ids:    HGNC: 51881   Entrez Gene: 563412   Ensembl: ENSG000001112187   OMIM: 6100865   UniProtKB: Q9NR223   

Export aliases for PRMT8 gene to outside databases

Previous GC identifers: GC12P003470 GC12P003600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRMT8 Gene:
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such
as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA
transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al.,
2005 (PubMed 16051612)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PRMT8 Gene:
PRMT8 (protein arginine methyltransferase 8) is a protein-coding gene. Diseases associated with PRMT8 include peripheral primitive neuroectodermal tumor, and primitive neuroectodermal tumor. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
Function: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N
monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein;
however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT8 gene promoter:
         AhR   MAZR   Pax-6   YY1   Arnt   E47   HEN1   Pax-3   E2F   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT8 promoter sequence
   Search Chromatin IP Primers for PRMT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13.3

PRMT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P003490:  view genomic region     (about GC identifiers)

Start:
3,490,515 bp from pter      End:
3,703,139 bp from pter
Size:
212,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 8  
Size: 394 amino acids; 45291 Da
Subunit: Homodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with
PRMT2 and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status
Sequence caution: Sequence=AAF91390.1; Type=Erroneous initiation; Sequence=BAG37987.1; Type=Frameshift;
Positions=45;
Secondary accessions: B2RDP0 Q8TBJ8
Alternative splicing: 2 isoforms:  Q9NR22-1   Q9NR22-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT8: NX_Q9NR22

Explore proteomics data for PRMT8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRMT8 (Q9NR22) (see all 10)
     KVVLDVG  DYYFDSY  HEEMLKD  KWLKPGG 


    See PRMT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243465.1  NP_062828.3  

    ENSEMBL proteins: 
     ENSP00000414507   ENSP00000372067  

    PRMT8 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT8
    Protein arginine N-methyltransferases

    2 InterPro protein domains:
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA

    Graphical View of Domain Structure for InterPro Entry Q9NR22

    ProtoNet protein and cluster: Q9NR22

    UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
    Domain: The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN,
    possibly leading to displace the N-terminal domain and activate the protein
    Domain: The N-terminal region (1-60) inhibits the enzymatic activity
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family. PRMT8 subfamily
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain


    PRMT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM8_HUMAN, Q9NR22
    Function: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N
    monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein;
    however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS
    Biophysicochemical properties: Kinetic parameters: KM=1.3 uM for GRGGFGGRGGFRGGRGG-NH2;

         Enzyme Numbers (IUBMB): EC 2.1.1.772 EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16051612
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ----
    GO:0008469histone-arginine N-methyltransferase activity IDA16051612
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA16051612
         
    PRMT8 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRMT8:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prmt8):
     hematopoietic system  immune system 

    PRMT8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRMT8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRMT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRMT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRMT8

    miRNA
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    miRTarBase miRNAs that target PRMT8:
    hsa-mir-330-3p (MIRT043830)

    Block miRNA regulation of human, mouse, rat PRMT8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRMT8 (see all 12):
    hsa-miR-3173-3p hsa-miR-676 hsa-miR-7-2* hsa-miR-27a hsa-miR-548o hsa-miR-103a hsa-miR-339-3p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidPRMT8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRMT8

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    GenScript: all cDNA clones in your preferred vector: PRMT8 (NM_019854)
    Sino Biological Human cDNA Clone for PRMT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM8_HUMAN, Q9NR22: Cell membrane; Lipid-anchor; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA16051612
    GO:0005737cytoplasm ----
    GO:0005829cytosol IBA--
    GO:0005886plasma membrane IDA16051612

    PRMT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT8: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRMT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRMT8 (Q9NR221, 3 ENSP000003720674) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT1Q998731, 3EBI-745545,EBI-78738 I2D: score=1 
    SYNCRIPO605061, 3, ENSP000003586354EBI-745545,EBI-1024357 I2D: score=1 STRING: ENSP00000358635
    COILP384323, ENSP000002403164I2D: score=2 STRING: ENSP00000240316
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    PRMT8Q9NR221EBI-745545,EBI-745545
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006479protein methylation ----
    GO:0008152metabolic process ----
    GO:0016571histone methylation IDA16051612
    GO:0018216peptidyl-arginine methylation IDA16051612

    PRMT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT8 (ANM8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRMT8 gene (3 alternative transcripts): 
    NM_001256537.1  NM_001256536.1  NM_019854.4  

    Unigene Cluster for PRMT8:

    Protein arginine methyltransferase 8
    Hs.504530  [show with all ESTs]
    Unigene Representative Sequence: AK026786
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452611 ENST00000382622(uc009zed.3 uc001qmf.3 uc001qmg.3 uc001qmh.3)
    ENST00000543701 ENST00000261252(uc009zee.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRMT8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRMT8 (see all 12):
    hsa-miR-3173-3p hsa-miR-676 hsa-miR-7-2* hsa-miR-27a hsa-miR-548o hsa-miR-103a hsa-miR-339-3p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidPRMT8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRMT8
    Clone
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    OriGene ORF clones in mouse, rat for PRMT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRMT8 (NM_019854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT8
    Primer
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    OriGene qPCR primer pairs and template standards for PRMT8
    OriGene qSTAR qPCR primer pairs in human, mouse for PRMT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRMT8
      QuantiTect SYBR Green Assays in human, mouse, rat PRMT8
      QuantiFast Probe-based Assays in human, mouse, rat PRMT8

    Additional mRNA sequence: 

    AF263539.1 AK026786.1 AK093651.1 AK315619.1 BC022458.1 

    3 DOTS entries:

    DT.91750857  DT.121129050  DT.100017281 

    Selected AceView cDNA sequences (see all 25):

    BG149561 BX098641 BM921694 AF263539 AA776911 AW088060 AA861463 BF433361 
    AK093651 BM975204 NM_019854 BC022458 BM805285 AI368503 BM547924 AK026786 
    AI150403 BG714739 BF953462 CD687488 AI927209 BE327021 BI489941 BF528491 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -                             -                     
    SP2:              -           -                 -                                 
    SP3:                                            -                                 


    ECgene alternative splicing isoforms for PRMT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRMT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACAAAAA
    PRMT8 Expression
    About this image


    PRMT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    PRMT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504530

    UniProtKB/Swiss-Prot: ANM8_HUMAN, Q9NR22
    Tissue specificity: Brain-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT8: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat PRMT8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT8 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt81 , 5 protein arginine N-methyltransferase 81, 5 93.06(n)1
    98.48(a)1
      6 (62.49 cM)5
    3818131  NM_201371.21  NP_958759.21 
     1276890115 
    chicken
    (Gallus gallus)
    Aves PRMT81 protein arginine methyltransferase 8 82.15(n)
    94.16(a)
      425989  XM_423669.4  XP_423669.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT86
    protein arginine methyltransferase 8
    90(a)
    1 ↔ 1
    5(81412340-81490293)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prmt81 protein arginine methyltransferase 8 79(n)
    90.31(a)
      100491340  XM_002938693.2  XP_002938739.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5560541 protein arginine N-methyltransferase 8-B-like 77.07(n)
    85.28(a)
      556054  XM_003200433.2  XP_003200481.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art16
    Arginine methyltransferase 1
    62(a)
    1 → many
    3R(6612203-6613946)
    worm
    (Caenorhabditis elegans)
    Secernentea prmt-16
    Protein PRMT-1 (prmt-1) mRNA, complete cds
    65(a)
    1 → many
    V(20267369-20269711) WBGene00013766
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT16
    Nuclear SAM-dependent mono- and asymmetric arginin...
    46(a)
    1 → many
    II(304930-305976) YBR034C
    rice
    (Oryza sativa)
    Liliopsida Os.184532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.97(n)    AK099826.1 


    ENSEMBL Gene Tree for PRMT8 (if available)
    TreeFam Gene Tree for PRMT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT8 gene
    PRMT62  PRMT32  CARM12  PRMT22  PRMT12  
    6 SIMAP similar genes for PRMT8 using alignment to 2 protein entries:     ANM8_HUMAN (see all proteins):
    PRMT1    PRMT3    HRMT1L2    PRMT2    PRMT6    CARM1

    PRMT8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRMT8 (see all 4047)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430471681,2
    C--3488574(+) GCTGGA/CAAGAG 1 -- us2k10--------
    rs1872258271,2
    --3488739(+) GTAGCC/TGTGAT 1 -- us2k10--------
    rs1922498061,2
    --3488765(+) TTCCAC/TCGTCA 1 -- us2k10--------
    rs1451457841,2
    --3488833(+) AAACTA/GAAAGT 1 -- us2k10--------
    rs20413081,2
    C,F,A,H--3488913(-) AGTCCT/CCAGCC 1 -- us2k111Minor allele frequency- C:0.38NA WA EA 374
    rs773854301,2
    C,F--3489096(+) TCCAGC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.27WA 118
    rs1173594391,2
    C,F--3489319(+) AGGATG/AGAAGC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs793218801,2
    F--3489325(+) GAAGCG/ATGTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs740556741,2
    C,F--3489521(+) ATTTTG/AAATAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1423074361,2
    --3489583(+) TTGCAA/GCATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRMT8 (3490515 - 3703139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PRMT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745435CNV Deletion23290073
    esv2293557CNV Deletion18987734
    esv2745436CNV Deletion23290073
    esv3874CNV Deletion18987735
    nsv581CNV Loss18451855
    nsv468980CNV Loss19166990
    nsv468981CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610086    OMIM disorders: --

    6 diseases for PRMT8:    
    About MalaCards
    peripheral primitive neuroectodermal tumor    primitive neuroectodermal tumor    coronary heart disease    kaposi's sarcoma
    sarcoma    ataxia

    1 disease from the University of Copenhagen DISEASES database for PRMT8:
    Peripheral primitive neuroectodermal tumor

    PRMT8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRMT8
    Human Genome Epidemiology (HuGE) Navigator: PRMT8 (2 documents)

    Export disorders for PRMT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT8 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PRMT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PubMed id 16051612)1, 2, 3 Lee J.... Bedford M.T. (J. Biol. Chem. 2005)
    2. Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. (PubMed id 18320585)1, 2, 9 Pahlich S.... Gehring H. (Proteins 2008)
    3. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. (PubMed id 17925405)1, 2, 9 Sayegh J.... Clarke S.G. (J. Biol. Chem. 2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (Nat. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo. (PubMed id 23620769)1 Scaramuzzino C....Pandey U.B. (PLoS ONE 2013)
    10. Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS. (PubMed id 23635657)1 Ravenscroft T.A....Rademakers R. (Neurobiol. Aging 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56341 HGNC: 5188 AceView: HRMT1L4 Ensembl:ENSG00000111218 euGenes: HUgn56341
    ECgene: PRMT8 H-InvDB: PRMT8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRMT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRMT8 gene:
    Search GeneIP for patents involving PRMT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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