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Aliases for PRMT7 Gene

Aliases for PRMT7 Gene

  • Protein Arginine Methyltransferase 7 2 3 5
  • [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7 4
  • Histone-Arginine N-Methyltransferase PRMT7 4
  • EC 2.1.1.321 4
  • KIAA1933 4
  • EC 2.1.1 63

External Ids for PRMT7 Gene

Previous GeneCards Identifiers for PRMT7 Gene

  • GC16P068122
  • GC16P066902
  • GC16P054218

Summaries for PRMT7 Gene

Entrez Gene Summary for PRMT7 Gene

  • Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRMT7 Gene

PRMT7 (Protein Arginine Methyltransferase 7) is a Protein Coding gene. Diseases associated with PRMT7 include Kabuki Syndrome 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include methyltransferase activity and ribonucleoprotein complex binding. An important paralog of this gene is PRMT9.

UniProtKB/Swiss-Prot for PRMT7 Gene

  • Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 Arg-3 to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Tocris Summary for PRMT7 Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT7 Gene

Genomics for PRMT7 Gene

Regulatory Elements for PRMT7 Gene

Enhancers for PRMT7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRMT7 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRMT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRMT7 Gene

Chromosome:
16
Start:
68,310,974 bp from pter
End:
68,358,829 bp from pter
Size:
47,856 bases
Orientation:
Plus strand

Genomic View for PRMT7 Gene

Genes around PRMT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT7 Gene

Proteins for PRMT7 Gene

  • Protein details for PRMT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM4-ANM7_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 7
    Protein Accession:
    Q9NVM4
    Secondary Accessions:
    • B3KPR0
    • B3KUG9
    • B4E379
    • Q96PV5
    • Q9H9L0

    Protein attributes for PRMT7 Gene

    Size:
    692 amino acids
    Molecular mass:
    78459 Da
    Quaternary structure:
    • Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
    Miscellaneous:
    • May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
    SequenceCaution:
    • Sequence=BAB14215.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRMT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT7 Gene

Proteomics data for PRMT7 Gene at MOPED

Selected DME Specific Peptides for PRMT7 Gene

Post-translational modifications for PRMT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT7 (PRMT7)
  • Abcam antibodies for PRMT7

Domains & Families for PRMT7 Gene

Gene Families for PRMT7 Gene

Protein Domains for PRMT7 Gene

Suggested Antigen Peptide Sequences for PRMT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVM4

UniProtKB/Swiss-Prot:

ANM7_HUMAN :
  • Contains 2 SAM-dependent MTase PRMT-type domains.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
Domain:
  • Contains 2 SAM-dependent MTase PRMT-type domains.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
genes like me logo Genes that share domains with PRMT7: view

Function for PRMT7 Gene

Molecular function for PRMT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 Arg-3 to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Enzyme Numbers (IUBMB) for PRMT7 Gene

Gene Ontology (GO) - Molecular Function for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016274 protein-arginine N-methyltransferase activity TAS --
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IBA --
GO:0042393 histone binding IC 15494416
GO:0043021 ribonucleoprotein complex binding IPI 17709427
genes like me logo Genes that share ontologies with PRMT7: view
genes like me logo Genes that share phenotypes with PRMT7: view

Animal Models for PRMT7 Gene

MGI Knock Outs for PRMT7:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRMT7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT7 Gene

Localization for PRMT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT7 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT7 Gene COMPARTMENTS Subcellular localization image for PRMT7 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PRMT7 Gene

Pathways & Interactions for PRMT7 Gene

genes like me logo Genes that share pathways with PRMT7: view

Pathways by source for PRMT7 Gene

1 GeneTex pathway for PRMT7 Gene
1 Cell Signaling Technology pathway for PRMT7 Gene

Gene Ontology (GO) - Biological Process for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly IMP 17709427
GO:0006325 chromatin organization TAS --
GO:0006349 regulation of gene expression by genetic imprinting ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0018216 peptidyl-arginine methylation IMP 17709427
genes like me logo Genes that share ontologies with PRMT7: view

No data available for SIGNOR curated interactions for PRMT7 Gene

Drugs & Compounds for PRMT7 Gene

(3) Drugs for PRMT7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for PRMT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRMT7: view

Transcripts for PRMT7 Gene

Unigene Clusters for PRMT7 Gene

Protein arginine methyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for PRMT7 Gene

GeneLoc Exon Structure for
PRMT7
ECgene alternative splicing isoforms for
PRMT7

Expression for PRMT7 Gene

mRNA expression in normal human tissues for PRMT7 Gene

Protein differential expression in normal tissues from HIPED for PRMT7 Gene

This gene is overexpressed in Fetal ovary (49.8) and Retina (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRMT7 Gene



SOURCE GeneReport for Unigene cluster for PRMT7 Gene Hs.653193

genes like me logo Genes that share expression patterns with PRMT7: view

Protein tissue co-expression partners for PRMT7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRMT7 Gene

Orthologs for PRMT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT7 35
  • 87.48 (n)
  • 87.57 (a)
PRMT7 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT7 35
  • 86.68 (n)
  • 88.08 (a)
PRMT7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt7 35
  • 84.01 (n)
  • 85.36 (a)
Prmt7 16
Prmt7 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRMT7 35
  • 97.23 (n)
  • 96.77 (a)
PRMT7 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prmt7 35
  • 83.12 (n)
  • 84.33 (a)
oppossum
(Monodelphis domestica)
Mammalia PRMT7 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT7 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRMT7 35
  • 67.93 (n)
  • 69.05 (a)
PRMT7 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT7 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt7 35
  • 63.14 (n)
  • 64.12 (a)
Str.95 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68979 35
zebrafish
(Danio rerio)
Actinopterygii prmt7 35
  • 64.55 (n)
  • 63.81 (a)
zgc66172 35
prmt7 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta ANM7_ANOGA 35
  • 50.03 (n)
  • 39.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Art7 35
  • 50.65 (n)
  • 38.7 (a)
Art7 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prmt-7 35
  • 44.64 (n)
  • 35.51 (a)
prmt-7 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT7 35
  • 44.95 (n)
  • 35.34 (a)
rice
(Oryza sativa)
Liliopsida Os06g0105500 35
  • 44.57 (n)
  • 34.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for PRMT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT7 Gene

ENSEMBL:
Gene Tree for PRMT7 (if available)
TreeFam:
Gene Tree for PRMT7 (if available)

Paralogs for PRMT7 Gene

Paralogs for PRMT7 Gene

(1) SIMAP similar genes for PRMT7 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PRMT7: view

Variants for PRMT7 Gene

Sequence variations from dbSNP and Humsavar for PRMT7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3890052 -- 68,344,953(-) CGTGT(A/G)TGTGT intron-variant
rs3961282 -- 68,331,254(-) gaaga(A/G)tctta intron-variant
rs4381598 -- 68,319,761(+) TTTCA(A/G)GTAAG intron-variant
rs12934423 -- 68,356,483(+) CCCGG(C/T)TGCAG intron-variant
rs12934542 -- 68,337,181(+) ATTAA(A/G)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT7 Gene

Variant ID Type Subtype PubMed ID
nsv510691 CNV Loss 20534489
nsv519368 CNV Loss 19592680

Variation tolerance for PRMT7 Gene

Residual Variation Intolerance Score: 4.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT7 Gene

Human Gene Mutation Database (HGMD)
PRMT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT7 Gene

Disorders for PRMT7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRMT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRMT7

Genetic Association Database (GAD)
PRMT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT7
genes like me logo Genes that share disorders with PRMT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT7 Gene

Publications for PRMT7 Gene

  1. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. (PMID: 15044439) Miranda T.B. … Clarke S. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. (PMID: 19110445) Wang H. … Qu J. (J. Am. Soc. Mass Spectrom. 2009) 3 23
  3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PMID: 17709427) Gonsalvez G.B. … Matera A.G. (J. Cell Biol. 2007) 3 23
  4. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PMID: 16051612) Lee J. … Bedford M.T. (J. Biol. Chem. 2005) 3 23
  5. Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. (PMID: 25605249) Baldwin R.M. … CA'tAc J. (Oncotarget 2015) 3

Products for PRMT7 Gene

Sources for PRMT7 Gene

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