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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRMT7 Gene

protein-coding   GIFtS: 53
GCID: GC16P068344

Protein Arginine Methyltransferase 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Arginine Methyltransferase 71 2     EC 2.1.1.-3
Histone-Arginine N-Methyltransferase PRMT72 3     EC 2.1.1.1253
[Myelin Basic Protein]-Arginine N-Methyltransferase PRMT72 3     EC 2.1.1.1263
Myelin Basic Protein-Arginine N-Methyltransferase2     KIAA19333
Protein Arginine N-Methyltransferase 72     EC 2.1.18

External Ids:    HGNC: 255571   Entrez Gene: 544962   Ensembl: ENSG000001326007   OMIM: 6100875   UniProtKB: Q9NVM43   

Export aliases for PRMT7 gene to outside databases

Previous GC identifers: GC16P068122 GC16P066902 GC16P054218


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRMT7 Gene:
Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases,
such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in
signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 (PubMed 15044439)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for PRMT7 Gene: 
PRMT7 (protein arginine methyltransferase 7) is a protein-coding gene. Diseases associated with PRMT7 include testicular cancer, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include S-adenosylmethionine-dependent methyltransferase activity and histone binding. An important paralog of this gene is PRMT10.

UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4
Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
(SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically
mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by
being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s,
possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell
(ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP)
in vitro; the relevance of such results is however unclear in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRMT7 gene promoter:
         GR   Pax-5   AML1a   POU3F1   RORalpha1   PPAR-gamma1   ARP-1   GR-alpha   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRMT7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

PRMT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068344:  view genomic region     (about GC identifiers)

Start:
68,344,877 bp from pter      End:
68,392,466 bp from pter
Size:
47,590 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 7  
Size: 692 amino acids; 78459 Da
Subunit: Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and
SNRPD3
Subcellular location: Cytoplasm, cytosol. Nucleus
Miscellaneous: May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for
testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers.
Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT)
Sequence caution: Sequence=BAB14215.1; Type=Erroneous initiation;
Secondary accessions: B3KPR0 B3KUG9 B4E379 Q96PV5 Q9H9L0
Alternative splicing: 4 isoforms:  Q9NVM4-1   Q9NVM4-2   Q9NVM4-3   Q9NVM4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT7: NX_Q9NVM4

Explore proteomics data for PRMT7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVM4

  • 2 DME Specific Peptides for PRMT7 (Q9NVM4)
     VLDIGTG  DTELIGEGA 

    PRMT7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRMT7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171753.1  NP_061896.1  

    ENSEMBL proteins: 
     ENSP00000454980   ENSP00000456364   ENSP00000456190   ENSP00000455538   ENSP00000455705  
     ENSP00000456848   ENSP00000414716   ENSP00000457381   ENSP00000343103   ENSP00000454776  
     ENSP00000409324   ENSP00000345775  

    Human Recombinant Protein Products for PRMT7: 
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    Novus Biologicals PRMT7 Proteins
    Novus Biologicals PRMT7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRMT7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15494416
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA15494416

    PRMT7 for ontologies           About GeneDecksing



    PRMT7 Antibody Products: 
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    Abcam antibodies for PRMT7
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    Assay Products for PRMT7: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRMT7 
    Cloud-Clone Corp. CLIAs for PRMT7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT7 
    Protein arginine N-methyltransferases

    4 InterPro protein domains:
     IPR014644 Arg_MeTrfase_PRMT7
     IPR025801 Arg_MeTrfase_PMTR7_chr
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA

    Graphical View of Domain Structure for InterPro Entry Q9NVM4

    ProtoNet protein and cluster: Q9NVM4

    UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4
    Similarity: Belongs to the protein arginine N-methyltransferase family. PRMT7 subfamily


    PRMT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM7_HUMAN, Q9NVM4
    Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
    symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
    symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
    (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically
    mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by
    being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s,
    possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell
    (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP)
    in vitro; the relevance of such results is however unclear in vivo
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Catalytic activity: S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine +
    [myelin basic protein]-N(omega)-methyl-arginine

         Enzyme Numbers (IUBMB): EC 2.1.1.1261 EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ----
    GO:0008469histone-arginine N-methyltransferase activity IDA15494416
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA15044439
         
    PRMT7 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prmt7):
     cellular 

    PRMT7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRMT7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRMT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRMT7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRMT7 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRMT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/25 Interacting proteins for PRMT7 (Q9NVM43 ENSP000003431034) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly IMP17709427
    GO:0006349regulation of gene expression by genetic imprinting ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006479protein methylation ----

    PRMT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRMT7 for compounds           About GeneDecksing

    EMD Millipore small molecules for PRMT7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRMT7 (ANM7)

    4 Novoseek inferred chemical compound relationships for PRMT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n(g),n(g)-dimethylarginine 84.5 1 11862754 (1)
    arginine 75.7 26 15044439 (3), 15056663 (1), 16051612 (1), 11413150 (1) (see all 18)
    adma 74.2 1 11862754 (1)
    s-adenosylmethionine 63.7 4 10903992 (1), 19405910 (1)

    Search CenterWatch for drugs/clinical trials and news about PRMT7 / ANM7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRMT7 gene (2 alternative transcripts): 
    NM_001184824.1  NM_019023.2  

    Unigene Cluster for PRMT7:

    Protein arginine methyltransferase 7
    Hs.653193  [show with all ESTs]
    Unigene Representative Sequence: AB067520
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000566657 ENST00000562381 ENST00000565745 ENST00000569571 ENST00000566341
    ENST00000564050 ENST00000569047 ENST00000449359(uc010vlg.2) ENST00000564441
    ENST00000565356 ENST00000562050 ENST00000563520 ENST00000565983 ENST00000339507(uc002evy.2)
    ENST00000568975 ENST00000563562 ENST00000561806 ENST00000562456
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRMT7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRMT7
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT7

    Additional mRNA sequence: 

    AB067520.1 AK001502.1 AK022739.1 AK056647.1 AK097175.1 AK304605.1 BC000146.1 BC127884.1 

    23 DOTS entries:

    DT.212531  DT.97844435  DT.208696  DT.95166029  DT.100773462  DT.100829738  DT.91736735  DT.91788226 
    DT.100702432  DT.100776289  DT.100776290  DT.91736740  DT.95360158  DT.65287875  DT.101967897  DT.92020339 
    DT.92420664  DT.97844433  DT.99999354  DT.100716961  DT.100767306  DT.95166027  DT.95215598 

    24/152 AceView cDNA sequences (see all 152):

    AK022739 BM547362 AL698140 CR610385 BF590702 AK001502 BP345848 BQ070378 
    AU125909 BF438197 BU189250 CR604457 BF224136 BP364420 AI435996 AW593557 
    BM922828 BP345733 NM_019023 H52857 BG675458 BQ053883 AI288686 BP346424 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT7 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                                                                  -                           
    SP2:                                                                                      -           -                           
    SP3:        -                                                                                                                     
    SP4:                                                                          -           -           -                           
    SP5:                                                              -     -                                                         


    ECgene alternative splicing isoforms for PRMT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRMT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATACCCC
    PRMT7 Expression
    About this image


    See PRMT7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRMT7

    SOURCE GeneReport for Unigene cluster: Hs.653193
        SABiosciences Expression via Pathway-Focused PCR Array including PRMT7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT7 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt71 , 5 protein arginine N-methyltransferase 71, 5 84.01(n)1
    85.36(a)1
      8 (53.11 cM)5
    2145721  NM_145404.11  NP_663379.11 
     1062109365 
    chicken
    (Gallus gallus)
    Aves PRMT71 protein arginine methyltransferase 7 67.93(n)
    69.05(a)
      415620  NM_001005831.1  NP_001005831.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT76
    Uncharacterized protein
    70(a)
    1 ↔ 1
    LGc(6753811-6790261)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689792 hypothetical protein MGC68979 76(n)    BC059311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661722 hypothetical protein MGC66172 75.39(n)   393475  BC044492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art71 Arginine methyltransferase 7 50.65(n)
    38.7(a)
      37664  NM_137909.3  NP_611753.4 
    worm
    (Caenorhabditis elegans)
    Secernentea prmt-71 Protein PRMT-7 43.66(n)
    34.59(a)
      172727  NM_060035.2  NP_492436.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRMT71 protein arginine N-methyltransferase 7 44.14(n)
    33.72(a)
      827358  NM_117758.2  NP_567508.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01055001 hypothetical protein 44.29(n)
    33.96(a)
      4339860  NM_001063091.1  NP_001056556.1 


    ENSEMBL Gene Tree for PRMT7 (if available)
    TreeFam Gene Tree for PRMT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRMT7 gene
    PRMT102  
    1 SIMAP similar gene for PRMT7 using alignment to 8 protein entries:     ANM7_HUMAN (see all proteins):
    PRMT1

    PRMT7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1024 SNPs in PRMT7 are shown (see all 1024)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880523031,2
    --68346935(+) GTTGGC/TCAGGC 2 -- int10--------
    rs1922767521,2
    --68347013(+) GTGAGC/TCACCG 2 -- int10--------
    rs1488405291,2
    --68347101(+) ATCCTA/GTGGAT 2 -- int10--------
    rs557360511,2
    C,F--68347121(+) TCACTA/GTAAGT 2 -- int12Minor allele frequency- G:0.05WA 120
    rs1842857061,2
    --68347188(+) AGGCAC/TGTCTG 2 -- int10--------
    rs1181853911,2
    F--68347189(+) GGCACG/ATCTGA 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1434551541,2
    --68347197(+) TGACAA/CAGGCA 2 -- int10--------
    rs1879940751,2
    --68347208(+) CATGAA/GCACCC 2 -- int10--------
    rs1178816561,2
    F--68347210(+) TGAACA/TCCCAG 2 -- int11Minor allele frequency- T:0.01NA 120
    rs757062221,2
    F--68347221(+) TCATCA/GCGCTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRMT7 (68344877 - 68392466 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRMT7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510691CNV Loss20534489
    nsv519368CNV Loss19592680


    Human Gene Mutation Database (HGMD): PRMT7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRMT7
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610087    OMIM disorders: --

    9 diseases for PRMT7:    About MalaCards
    testicular cancer    intrahepatic cholangiocarcinoma    germ cell tumors    cholangiocarcinoma
    kaposi's sarcoma    lung cancer    sarcoma    endotheliitis
    leukemia


    PRMT7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRMT7

    Export disorders for PRMT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRMT7 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with PRMT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. (PubMed id 15044439)1, 2, 3, 9 Miranda T.B.... Clarke S. (2004)
    2. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. (PubMed id 19110445)1, 2, 9 Wang H.... Qu J. (2009)
    3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PubMed id 17709427)1, 2, 9 Gonsalvez G.B....Matera A.G. (2007)
    4. Genome-wide association studies of serum magnesium, p otassium, and sodium concentrations identify six Loci influencing serum magnesi um levels. (PubMed id 20700443)1, 4 Meyer T.E.... . (2010)
    5. PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. (PubMed id 15494416)1, 2 Lee J.H....Pestka S. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
    9. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PubMed id 16051612)1, 9 Lee J....Bedford M.T. (2005)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54496 HGNC: 25557 AceView: PRMT7 Ensembl:ENSG00000132600 euGenes: HUgn54496
    ECgene: PRMT7 H-InvDB: PRMT7

    (According to HUGE)
    About This Section
    HUGE: KIAA1933

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRMT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRMT7 gene:
    Search GeneIP for patents involving PRMT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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