Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRMT7 Gene

Aliases for PRMT7 Gene

  • Protein Arginine Methyltransferase 7 2 3 5
  • [Myelin Basic Protein]-Arginine N-Methyltransferase PRMT7 3 4
  • Histone-Arginine N-Methyltransferase PRMT7 3 4
  • Myelin Basic Protein-Arginine N-Methyltransferase 3
  • Protein Arginine N-Methyltransferase 7 3
  • EC 2.1.1.321 4
  • KIAA1933 4
  • EC 2.1.1 61
  • SBIDDS 3

External Ids for PRMT7 Gene

Previous GeneCards Identifiers for PRMT7 Gene

  • GC16P068122
  • GC16P066902
  • GC16P054218

Summaries for PRMT7 Gene

Entrez Gene Summary for PRMT7 Gene

  • Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRMT7 Gene

PRMT7 (Protein Arginine Methyltransferase 7) is a Protein Coding gene. Diseases associated with PRMT7 include Short Stature-Brachydactyly-Obesity-Global Developmental Delay Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include methyltransferase activity and ribonucleoprotein complex binding. An important paralog of this gene is PRMT9.

UniProtKB/Swiss-Prot for PRMT7 Gene

  • Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 Arg-3 to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Tocris Summary for PRMT7 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT7 Gene

Genomics for PRMT7 Gene

Regulatory Elements for PRMT7 Gene

Enhancers for PRMT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068279 1.7 FANTOM5 Ensembl ENCODE 44.5 -24.5 -24514 13.5 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 SLC30A9 FOS SP5 JUNB PRMT7 SLC7A6 NFATC3 DPEP2 SLC7A6OS RNU4-30P DUS2 RANBP10 PSMB10 LRRC36
GH16F068267 1.7 FANTOM5 Ensembl ENCODE 34.1 -38.4 -38403 10.7 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC7A6 PRMT7 DPEP2 NFATC3 THAP11 SLC7A6OS PSMB10 ZFP90 EDC4 RANBP10
GH16F068381 1.4 FANTOM5 Ensembl ENCODE 41.4 +74.3 74265 6.9 PKNOX1 KLF17 RAD21 YY1 ZNF335 GATA2 SCRT2 EGR2 SMAD5 ELF1 PRMT7 SLC7A6 SLC7A6OS RNU4-36P DUS2 GC16M068393 ENSG00000279693
GH16F068355 1 Ensembl ENCODE 48.3 +45.4 45406 1.9 CTCF USF1 TBL1XR1 MAX ZIC2 THRB RAD21 RELA POLR2A EGR1 PRMT7 SLC7A6 RNU6-1262P SLC7A6OS ENSG00000212445 DUS2 ENSG00000279693 RNU4-30P
GH16F068326 1.2 Ensembl ENCODE 32.4 +17.8 17782 3.7 ARID4B FEZF1 ZNF48 BRCA1 GLIS2 ZNF143 FOS ZNF263 SP5 TSHZ1 PRMT7 SLC7A6 DUS2 DPEP2 RNU4-30P ENSG00000259797
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRMT7 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001506073 126 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for PRMT7 Gene

Chromosome:
16
Start:
68,310,974 bp from pter
End:
68,358,829 bp from pter
Size:
47,856 bases
Orientation:
Plus strand

Genomic View for PRMT7 Gene

Genes around PRMT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT7 Gene

Proteins for PRMT7 Gene

  • Protein details for PRMT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM4-ANM7_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 7
    Protein Accession:
    Q9NVM4
    Secondary Accessions:
    • B3KPR0
    • B3KUG9
    • B4E379
    • Q96PV5
    • Q9H9L0

    Protein attributes for PRMT7 Gene

    Size:
    692 amino acids
    Molecular mass:
    78459 Da
    Quaternary structure:
    • Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and SNRPD3.
    Miscellaneous:
    • May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
    SequenceCaution:
    • Sequence=BAB14215.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRMT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT7 Gene

Selected DME Specific Peptides for PRMT7 Gene

Q9NVM4:
  • VLDIGTG
  • DTELIGEGA

Post-translational modifications for PRMT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT7 (PRMT7)
  • Abcam antibodies for PRMT7

Domains & Families for PRMT7 Gene

Gene Families for PRMT7 Gene

Protein Domains for PRMT7 Gene

Suggested Antigen Peptide Sequences for PRMT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVM4

UniProtKB/Swiss-Prot:

ANM7_HUMAN :
  • Contains 2 SAM-dependent MTase PRMT-type domains.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
Domain:
  • Contains 2 SAM-dependent MTase PRMT-type domains.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
genes like me logo Genes that share domains with PRMT7: view

Function for PRMT7 Gene

Molecular function for PRMT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 Arg-3 to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Enzyme Numbers (IUBMB) for PRMT7 Gene

Gene Ontology (GO) - Molecular Function for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008469 histone-arginine N-methyltransferase activity IDA 15494416
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 15044439
GO:0016274 protein-arginine N-methyltransferase activity TAS --
GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity IDA 15494416
genes like me logo Genes that share ontologies with PRMT7: view
genes like me logo Genes that share phenotypes with PRMT7: view

Animal Models for PRMT7 Gene

MGI Knock Outs for PRMT7:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRMT7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT7 Gene

Localization for PRMT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT7 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15494416
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 15494416
genes like me logo Genes that share ontologies with PRMT7: view

Pathways & Interactions for PRMT7 Gene

genes like me logo Genes that share pathways with PRMT7: view

Pathways by source for PRMT7 Gene

1 GeneTex pathway for PRMT7 Gene
1 Cell Signaling Technology pathway for PRMT7 Gene

Gene Ontology (GO) - Biological Process for PRMT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly IMP 17709427
GO:0006349 regulation of gene expression by genetic imprinting ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006479 protein methylation IEA --
genes like me logo Genes that share ontologies with PRMT7: view

No data available for SIGNOR curated interactions for PRMT7 Gene

Drugs & Compounds for PRMT7 Gene

(3) Drugs for PRMT7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for PRMT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRMT7: view

Transcripts for PRMT7 Gene

Unigene Clusters for PRMT7 Gene

Protein arginine methyltransferase 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for PRMT7 Gene

GeneLoc Exon Structure for
PRMT7
ECgene alternative splicing isoforms for
PRMT7

Expression for PRMT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRMT7 Gene

Protein differential expression in normal tissues from HIPED for PRMT7 Gene

This gene is overexpressed in Fetal ovary (49.8) and Retina (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRMT7 Gene



Protein tissue co-expression partners for PRMT7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRMT7 Gene:

PRMT7

SOURCE GeneReport for Unigene cluster for PRMT7 Gene:

Hs.653193
genes like me logo Genes that share expression patterns with PRMT7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRMT7 Gene

Orthologs for PRMT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT7 34 35
  • 97.23 (n)
cow
(Bos Taurus)
Mammalia PRMT7 34 35
  • 87.48 (n)
dog
(Canis familiaris)
Mammalia PRMT7 34 35
  • 86.68 (n)
mouse
(Mus musculus)
Mammalia Prmt7 34 16 35
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Prmt7 34
  • 83.12 (n)
oppossum
(Monodelphis domestica)
Mammalia PRMT7 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT7 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRMT7 34 35
  • 67.93 (n)
lizard
(Anolis carolinensis)
Reptilia PRMT7 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt7 34
  • 63.14 (n)
Str.95 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68979 34
zebrafish
(Danio rerio)
Actinopterygii prmt7 34 35
  • 64.55 (n)
zgc66172 34
fruit fly
(Drosophila melanogaster)
Insecta Art7 34 35
  • 50.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta ANM7_ANOGA 34
  • 50.03 (n)
worm
(Caenorhabditis elegans)
Secernentea prmt-7 34 35
  • 44.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT7 34
  • 44.95 (n)
rice
(Oryza sativa)
Liliopsida Os06g0105500 34
  • 44.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for PRMT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT7 Gene

ENSEMBL:
Gene Tree for PRMT7 (if available)
TreeFam:
Gene Tree for PRMT7 (if available)

Paralogs for PRMT7 Gene

Paralogs for PRMT7 Gene

(1) SIMAP similar genes for PRMT7 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PRMT7: view

Variants for PRMT7 Gene

Sequence variations from dbSNP and Humsavar for PRMT7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs149170494 Pathogenic 68,316,074(+) TGCAA(C/G)GTACT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs201824659 Pathogenic 68,346,144(+) GCCTA(G/T)CCCTG splice-acceptor-variant
rs751670999 Pathogenic 68,352,314(+) ACTTC(C/T)GGTAC nc-transcript-variant, reference, missense
rs762515973 Pathogenic 68,346,248(+) AGGAC(A/G)GAACT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10707423 -- 68,327,922(+) TGAGA(-/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT7 Gene

Variant ID Type Subtype PubMed ID
esv3582280 CNV loss 25503493
esv3638905 CNV loss 21293372
nsv510691 CNV deletion 20534489
nsv519368 CNV loss 19592680

Variation tolerance for PRMT7 Gene

Residual Variation Intolerance Score: 4.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT7 Gene

Human Gene Mutation Database (HGMD)
PRMT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT7 Gene

Disorders for PRMT7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT7 Gene - From: Orphanet

- elite association - COSMIC cancer census association via MalaCards
Search PRMT7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ANM7_HUMAN
  • Note=Defects in PRMT7 are associated with mild intellectual disabilityy, obesity and symmetrical shortening of the digits and posterior metacarpals and metatarsals. The phenotype is a phenocopy of pseudohypoparathyroidism (PHP). {ECO:0000269 PubMed:26429889}.

Relevant External Links for PRMT7

Genetic Association Database (GAD)
PRMT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT7
genes like me logo Genes that share disorders with PRMT7: view

No data available for Genatlas for PRMT7 Gene

Publications for PRMT7 Gene

  1. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. (PMID: 15044439) Miranda T.B. … Clarke S. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. (PMID: 19110445) Wang H. … Qu J. (J. Am. Soc. Mass Spectrom. 2009) 3 4 22 64
  3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PMID: 17709427) Gonsalvez G.B. … Matera A.G. (J. Cell Biol. 2007) 3 4 22 64
  4. Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop. (PMID: 25294873) Feng Y. … Clarke S.G. (J. Biol. Chem. 2014) 3 4 64
  5. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PMID: 20700443) Meyer T.E. … . (PLoS Genet. 2010) 3 46 64

Products for PRMT7 Gene

Sources for PRMT7 Gene

Content
Loading form....