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PRMT7 Gene

protein-coding   GIFtS: 53
GCID: GC16P068344

Protein Arginine Methyltransferase 7

  Search for PRMT7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 71 2     Protein Arginine N-Methyltransferase 72
Histone-Arginine N-Methyltransferase PRMT72 3     EC 2.1.1.-3
[Myelin Basic Protein]-Arginine N-Methyltransferase PRMT72 3     EC 2.1.1.1253
KIAA19333 5     EC 2.1.1.1263
Myelin Basic Protein-Arginine N-Methyltransferase2     EC 2.1.18

External Ids:    HGNC: 255571   Entrez Gene: 544962   Ensembl: ENSG000001326007   OMIM: 6100875   UniProtKB: Q9NVM43   

Export aliases for PRMT7 gene to outside databases

Previous GC identifers: GC16P068122 GC16P066902 GC16P054218


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRMT7 Gene:
Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases,
such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in
signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 (PubMed 15044439)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for PRMT7 Gene:
PRMT7 (protein arginine methyltransferase 7) is a protein-coding gene. GO annotations related to this gene include S-adenosylmethionine-dependent methyltransferase activity and histone binding. An important paralog of this gene is PRMT9.

UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4
Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
(SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically
mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by
being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s,
possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell
(ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP)
in vitro; the relevance of such results is however unclear in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT7 gene promoter:
         GR   Pax-5   AML1a   POU3F1   RORalpha1   PPAR-gamma1   ARP-1   GR-alpha   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT7 promoter sequence
   Search Chromatin IP Primers for PRMT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

PRMT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068344:  view genomic region     (about GC identifiers)

Start:
68,344,877 bp from pter      End:
68,392,466 bp from pter
Size:
47,590 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 7  
Size: 692 amino acids; 78459 Da
Subunit: Homodimer and heterodimer (By similarity). Interacts with CTCFL (By similarity). Interacts with PRMT5 and
SNRPD3
Miscellaneous: May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for
testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers.
Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT)
Sequence caution: Sequence=BAB14215.1; Type=Erroneous initiation;
Secondary accessions: B3KPR0 B3KUG9 B4E379 Q96PV5 Q9H9L0
Alternative splicing: 4 isoforms:  Q9NVM4-1   Q9NVM4-2   Q9NVM4-3   Q9NVM4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT7: NX_Q9NVM4

Explore proteomics data for PRMT7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PRMT7 (Q9NVM4)
     VLDIGTG  DTELIGEGA 


    See PRMT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171753.1  NP_001276947.1  NP_061896.1  

    ENSEMBL proteins: 
     ENSP00000454980   ENSP00000456364   ENSP00000456190   ENSP00000455538   ENSP00000455705  
     ENSP00000456848   ENSP00000414716   ENSP00000457381   ENSP00000343103   ENSP00000454776  
     ENSP00000409324   ENSP00000345775  

    PRMT7 Human Recombinant Protein Products:

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    Novus Biologicals PRMT7 Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for PRMT7

     
    Search eBioscience for Proteins for PRMT7 

    PRMT7 Antibody Products:

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    PRMT7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PRMT7
    Cloud-Clone Corp. CLIAs for PRMT7
    Search eBioscience for ELISAs for PRMT7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT7
    Protein arginine N-methyltransferases

    3 InterPro protein domains:
     IPR014644 MeTrfase_PRMT7
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA

    Graphical View of Domain Structure for InterPro Entry Q9NVM4

    ProtoNet protein and cluster: Q9NVM4

    UniProtKB/Swiss-Prot: ANM7_HUMAN, Q9NVM4
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family. PRMT7 subfamily
    Similarity: Contains 2 SAM-dependent MTase PRMT-type domains


    Find genes that share domains with PRMT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM7_HUMAN, Q9NVM4
    Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
    symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
    symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
    (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically
    mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by
    being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s,
    possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell
    (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP)
    in vitro; the relevance of such results is however unclear in vivo
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Catalytic activity: S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine +
    [myelin basic protein]-N(omega)-methyl-arginine

         Enzyme Numbers (IUBMB): EC 2.1.1.1261 EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ----
    GO:0008469histone-arginine N-methyltransferase activity IDA15494416
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IDA15044439
         
    Find genes that share ontologies with PRMT7           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prmt7):
     cellular 

    Find genes that share phenotypes with PRMT7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRMT7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRMT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRMT7

    miRNA
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    miRTarBase miRNAs that target PRMT7:
    hsa-mir-30b-5p (MIRT046164), hsa-mir-10b-5p (MIRT047476), hsa-mir-484 (MIRT042041)

    Block miRNA regulation of human, mouse, rat PRMT7 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRMT7

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    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT7 (NM_019023)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT7
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    Addgene plasmids for PRMT7 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM7_HUMAN, Q9NVM4: Cytoplasm, cytosol. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA15494416
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with PRMT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRMT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for PRMT7 (Q9NVM43 ENSP000003431034) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly IMP17709427
    GO:0006349regulation of gene expression by genetic imprinting ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006479protein methylation ----

    Find genes that share ontologies with PRMT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT7 (ANM7)

    4 Novoseek inferred chemical compound relationships for PRMT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n(g),n(g)-dimethylarginine 84.5 1 11862754 (1)
    arginine 75.7 26 15044439 (3), 15056663 (1), 16051612 (1), 11413150 (1) (see all 18)
    adma 74.2 1 11862754 (1)
    s-adenosylmethionine 63.7 4 10903992 (1), 19405910 (1)



    Find genes that share compounds with PRMT7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRMT7 gene (3 alternative transcripts): 
    NM_001184824.1  NM_001290018.1  NM_019023.2  

    Unigene Cluster for PRMT7:

    Protein arginine methyltransferase 7
    Hs.653193  [show with all ESTs]
    Unigene Representative Sequence: AB067520
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000566657 ENST00000562381 ENST00000565745 ENST00000569571 ENST00000566341
    ENST00000564050 ENST00000569047 ENST00000449359(uc010vlg.2) ENST00000564441
    ENST00000565356 ENST00000562050 ENST00000563520 ENST00000565983 ENST00000339507(uc002evy.2)
    ENST00000568975 ENST00000563562 ENST00000561806 ENST00000562456
    miRNA
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    Addgene plasmids for PRMT7 
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      QuantiTect SYBR Green Assays in human, mouse, rat PRMT7
      QuantiFast Probe-based Assays in human, mouse, rat PRMT7

    Additional mRNA sequence: 

    AB067520.1 AK001502.1 AK022739.1 AK056647.1 AK097175.1 AK304605.1 BC000146.1 BC127884.1 

    23 DOTS entries:

    DT.212531  DT.97844435  DT.208696  DT.95166029  DT.100773462  DT.100829738  DT.91736735  DT.91788226 
    DT.100702432  DT.100776289  DT.100776290  DT.91736740  DT.95360158  DT.65287875  DT.101967897  DT.92020339 
    DT.92420664  DT.97844433  DT.99999354  DT.100716961  DT.100767306  DT.95166027  DT.95215598 

    Selected AceView cDNA sequences (see all 152):

    H52857 BM922828 BU189250 AL698140 CR604457 BF590702 BP346424 BQ070378 
    BU187820 BF062807 AW593557 CR610385 BP345848 BU738337 BP345733 BQ053883 
    BF438197 NM_019023 AI435996 BM663052 AK001502 BG675458 BP364420 AU125909 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRMT7 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                                                                  -                           
    SP2:                                                                                      -           -                           
    SP3:        -                                                                                                                     
    SP4:                                                                          -           -           -                           
    SP5:                                                              -     -                                                         


    ECgene alternative splicing isoforms for PRMT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRMT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATACCCC
    PRMT7 Expression
    About this image

    PRMT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653193
        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT7: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat PRMT7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT7 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt71 , 5 protein arginine N-methyltransferase 71, 5 84.01(n)1
    85.36(a)1
      8 (53.11 cM)5
    2145721  NM_145404.11  NP_663379.11 
     1062109365 
    chicken
    (Gallus gallus)
    Aves PRMT71 protein arginine methyltransferase 7 67.93(n)
    69.05(a)
      415620  NM_001005831.1  NP_001005831.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT76
    protein arginine methyltransferase 7
    70(a)
    1 ↔ 1
    LGc(6753811-6790261)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689792 hypothetical protein MGC68979 76(n)    BC059311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661722 hypothetical protein MGC66172 75.39(n)   393475  BC044492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art71 Arginine methyltransferase 7 50.65(n)
    38.7(a)
      37664  NM_137909.4  NP_611753.4 
    worm
    (Caenorhabditis elegans)
    Secernentea prmt-71 prmt-7 44.64(n)
    35.51(a)
      172727  NM_060035.3  NP_492436.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRMT71 PRMT7 44.95(n)
    35.34(a)
      827358  NM_117758.2  NP_567508.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01055001 Os06g0105500 44.57(n)
    34.16(a)
      4339860  NM_001063091.1  NP_001056556.1 


    ENSEMBL Gene Tree for PRMT7 (if available)
    TreeFam Gene Tree for PRMT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT7 gene
    PRMT92  
    1 SIMAP similar gene for PRMT7 using alignment to 8 protein entries:     ANM7_HUMAN (see all proteins):
    PRMT1

    Find genes that share paralogs with PRMT7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRMT7 (see all 1024)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880523031,2
    --68346935(+) GTTGGC/TCAGGC 2 -- int10--------
    rs1922767521,2
    --68347013(+) GTGAGC/TCACCG 2 -- int10--------
    rs1488405291,2
    --68347101(+) ATCCTA/GTGGAT 2 -- int10--------
    rs557360511,2
    C,F--68347121(+) TCACTA/GTAAGT 2 -- int12Minor allele frequency- G:0.05WA 120
    rs1842857061,2
    --68347188(+) AGGCAC/TGTCTG 2 -- int10--------
    rs1181853911,2
    F--68347189(+) GGCACG/ATCTGA 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1434551541,2
    --68347197(+) TGACAA/CAGGCA 2 -- int10--------
    rs1879940751,2
    --68347208(+) CATGAA/GCACCC 2 -- int10--------
    rs1178816561,2
    F--68347210(+) TGAACA/TCCCAG 2 -- int11Minor allele frequency- T:0.01NA 120
    rs757062221,2
    F--68347221(+) TCATCA/GCGCTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRMT7 (68344877 - 68392466 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRMT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510691CNV Loss20534489
    nsv519368CNV Loss19592680

    Human Gene Mutation Database (HGMD): PRMT7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRMT7
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610087    OMIM disorders: --


    Find genes that share disorders with PRMT7           About GenesLikeMe

    Genetic Association Database (GAD): PRMT7

    Export disorders for PRMT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT7 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with PRMT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. (PubMed id 15044439)1, 2, 3, 9 Miranda T.B.... Clarke S. (J. Biol. Chem. 2004)
    2. Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. (PubMed id 19110445)1, 2, 9 Wang H.... Qu J. (J. Am. Soc. Mass Spectrom. 2009)
    3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PubMed id 17709427)1, 2, 9 Gonsalvez G.B....Matera A.G. (J. Cell Biol. 2007)
    4. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PubMed id 20700443)1, 4 Meyer T.E.... . (PLoS Genet. 2010)
    5. PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. (PubMed id 15494416)1, 2 Lee J.-H.... Pestka S. (J. Biol. Chem. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    9. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. (PubMed id 16051612)1, 9 Lee J.... Bedford M.T. (J. Biol. Chem. 2005)
    10. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54496 HGNC: 25557 AceView: PRMT7 Ensembl:ENSG00000132600 euGenes: HUgn54496
    ECgene: PRMT7 H-InvDB: PRMT7

    (According to HUGE)
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    HUGE: KIAA1933

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRMT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRMT7 gene:
    Search GeneIP for patents involving PRMT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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