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Aliases for PRMT6 Gene

Aliases for PRMT6 Gene

  • Protein Arginine Methyltransferase 6 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6 3 4
  • Histone-Arginine N-Methyltransferase PRMT6 3 4
  • HRMT1L6 3 4
  • HMT1 HnRNP Methyltransferase-Like 6 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 6 3
  • EC 2.1.1.319 4

External Ids for PRMT6 Gene

Previous HGNC Symbols for PRMT6 Gene

  • HRMT1L6

Previous GeneCards Identifiers for PRMT6 Gene

  • GC01P108100
  • GC01P106581
  • GC01P106756
  • GC01P106954
  • GC01P107400
  • GC01P107599
  • GC01P105545

Summaries for PRMT6 Gene

Entrez Gene Summary for PRMT6 Gene

  • The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

GeneCards Summary for PRMT6 Gene

PRMT6 (Protein Arginine Methyltransferase 6) is a Protein Coding gene. Diseases associated with PRMT6 include Hiv-1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include methyltransferase activity and protein methyltransferase activity. An important paralog of this gene is PRMT2.

UniProtKB/Swiss-Prot for PRMT6 Gene

  • Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 Arg-2 to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 Lys-4 (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 Arg-3 (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

Tocris Summary for PRMT6 Gene

Gene Wiki entry for PRMT6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT6 Gene

Genomics for PRMT6 Gene

Regulatory Elements for PRMT6 Gene

Enhancers for PRMT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRMT6 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRMT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRMT6 Gene

Chromosome:
1
Start:
107,056,645 bp from pter
End:
107,059,294 bp from pter
Size:
2,650 bases
Orientation:
Plus strand

Genomic View for PRMT6 Gene

Genes around PRMT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT6 Gene

Proteins for PRMT6 Gene

  • Protein details for PRMT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA8-ANM6_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 6
    Protein Accession:
    Q96LA8
    Secondary Accessions:
    • A3KME1
    • B4DID8
    • Q5T5Y5
    • Q6DKI4
    • Q9NVR8

    Protein attributes for PRMT6 Gene

    Size:
    375 amino acids
    Molecular mass:
    41938 Da
    Quaternary structure:
    • Interacts with (and methylates) HIV-1 Tat, Rev and Nucleocapsid protein p7 (NC). Interacts with EPB41L3 and NCOA1.
    SequenceCaution:
    • Sequence=AAH02729.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH63446.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT6 Gene

    Alternative splice isoforms for PRMT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT6 Gene

Proteomics data for PRMT6 Gene at MOPED

Post-translational modifications for PRMT6 Gene

  • Automethylation enhances its stability and antiretroviral activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRMT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT6 (PRMT6)
  • Abcam antibodies for PRMT6

No data available for DME Specific Peptides for PRMT6 Gene

Domains & Families for PRMT6 Gene

Gene Families for PRMT6 Gene

Protein Domains for PRMT6 Gene

Suggested Antigen Peptide Sequences for PRMT6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LA8

UniProtKB/Swiss-Prot:

ANM6_HUMAN :
  • Contains 1 SAM-dependent MTase PRMT-type domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
genes like me logo Genes that share domains with PRMT6: view

Function for PRMT6 Gene

Molecular function for PRMT6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=18.6 uM for AdoMet {ECO:0000269 PubMed:18263580}; KM=501 uM for WGGYSRGGYGGW peptide {ECO:0000269 PubMed:18263580}; KM=183.7 uM for WGGYSR(MMA)GGYGGW monomethylated peptide {ECO:0000269 PubMed:18263580}; Vmax=3.3 nmol/min/mg enzyme with AdoMet as substrate {ECO:0000269 PubMed:18263580}; Vmax=1.8 nmol/min/mg enzyme with WGGYSRGGYGGW peptide as substrate {ECO:0000269 PubMed:18263580}; Vmax=3.2 nmol/min/mg enzyme with WGGYSR(MMA)GGYGGW monomethylated peptide as substrate {ECO:0000269 PubMed:18263580};
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 Arg-2 to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 Lys-4 (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 Arg-3 (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

Enzyme Numbers (IUBMB) for PRMT6 Gene

Gene Ontology (GO) - Molecular Function for PRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016274 protein-arginine N-methyltransferase activity IEA,TAS --
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IDA 11724789
GO:0042393 histone binding IDA 17898714
genes like me logo Genes that share ontologies with PRMT6: view
genes like me logo Genes that share phenotypes with PRMT6: view

Animal Models for PRMT6 Gene

MGI Knock Outs for PRMT6:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT6 Gene

Localization for PRMT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT6 Gene COMPARTMENTS Subcellular localization image for PRMT6 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PRMT6 Gene

Pathways & Interactions for PRMT6 Gene

genes like me logo Genes that share pathways with PRMT6: view

Pathways by source for PRMT6 Gene

1 GeneTex pathway for PRMT6 Gene
1 Cell Signaling Technology pathway for PRMT6 Gene

Gene Ontology (GO) - Biological Process for PRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0016049 cell growth IEA --
genes like me logo Genes that share ontologies with PRMT6: view

No data available for SIGNOR curated interactions for PRMT6 Gene

Drugs & Compounds for PRMT6 Gene

(8) Drugs for PRMT6 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Entacapone Approved, Investigational Pharma COMT inhibitor, Potent COMT inhibitor; blocks alpha-synuclein aggregation 48
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
EPZ004777 Pharma DOT1L inhibitor 0
PFI-2 Pharma 0

(1) Additional Compounds for PRMT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for PRMT6 Gene

Compound Action Cas Number
Entacapone COMT inhibitor 130929-57-6
EPZ004777 DOT1L inhibitor 1338466-77-5
PFI-2 1627676-59-8
SGI-1027 DNMT inhibitor 1020149-73-8
genes like me logo Genes that share compounds with PRMT6: view

Transcripts for PRMT6 Gene

mRNA/cDNA for PRMT6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRMT6 Gene

Protein arginine methyltransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT6 Gene

No ASD Table

Relevant External Links for PRMT6 Gene

GeneLoc Exon Structure for
PRMT6
ECgene alternative splicing isoforms for
PRMT6

Expression for PRMT6 Gene

mRNA expression in normal human tissues for PRMT6 Gene

Protein differential expression in normal tissues from HIPED for PRMT6 Gene

This gene is overexpressed in Adrenal (37.3) and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRMT6 Gene



SOURCE GeneReport for Unigene cluster for PRMT6 Gene Hs.26006

mRNA Expression by UniProt/SwissProt for PRMT6 Gene

Q96LA8-ANM6_HUMAN
Tissue specificity: Highly expressed in kidney and testis.
genes like me logo Genes that share expression patterns with PRMT6: view

Protein tissue co-expression partners for PRMT6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRMT6 Gene

Orthologs for PRMT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT6 35
  • 92.09 (n)
  • 92.53 (a)
PRMT6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT6 35
  • 86.13 (n)
  • 86.4 (a)
PRMT6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt6 35
  • 89.72 (n)
  • 93.66 (a)
Prmt6 16
Prmt6 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRMT6 35
  • 99.56 (n)
  • 100 (a)
PRMT6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911617 35
  • 89.6 (n)
  • 93.87 (a)
oppossum
(Monodelphis domestica)
Mammalia PRMT6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 13 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt6 35
  • 61.13 (n)
  • 59.35 (a)
Str.3505 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25304 35
zebrafish
(Danio rerio)
Actinopterygii prmt6 35
  • 61.26 (n)
  • 55.46 (a)
prmt6 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16840 37
  • 40 (a)
Art8 35
  • 50.46 (n)
  • 43.45 (a)
Art2 36
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008846 35
  • 50.97 (n)
  • 43.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT6 35
  • 52 (n)
  • 51.13 (a)
rice
(Oryza sativa)
Liliopsida Os10g0489100 35
  • 52 (n)
  • 48.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9497 36
  • 35 (a)
OneToOne
Species with no ortholog for PRMT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRMT6 Gene

ENSEMBL:
Gene Tree for PRMT6 (if available)
TreeFam:
Gene Tree for PRMT6 (if available)

Paralogs for PRMT6 Gene

Paralogs for PRMT6 Gene

(6) SIMAP similar genes for PRMT6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRMT6: view

Variants for PRMT6 Gene

Sequence variations from dbSNP and Humsavar for PRMT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2232016 - 107,057,296(+) CATAG(A/C/T)CCCCA reference, missense
rs2910 -- 107,059,252(-) TAAAA(C/G)GGCAG utr-variant-3-prime
rs1730850 -- 107,055,366(-) GTATG(A/G)GTGTC upstream-variant-2KB
rs1762482 -- 107,056,380(+) AGTTC(A/C)GCAGA upstream-variant-2KB
rs2232006 -- 107,055,891(+) CATTT(C/G)CACTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRMT6 Gene

Variant ID Type Subtype PubMed ID
dgv82e1 CNV Complex 17122850
nsv482070 CNV Gain 20164927

Variation tolerance for PRMT6 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRMT6 Gene

Disorders for PRMT6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PRMT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRMT6

Genetic Association Database (GAD)
PRMT6
Human Genome Epidemiology (HuGE) Navigator
PRMT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT6
genes like me logo Genes that share disorders with PRMT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT6 Gene

Publications for PRMT6 Gene

  1. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. (PMID: 11724789) Frankel A. … Bedford M.T. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Thrombospondin-1 is a transcriptional repression target of PRMT6. (PMID: 19509293) Michaud-Levesque J. … Richard S. (J. Biol. Chem. 2009) 3 23
  3. Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. (PMID: 17415034) Invernizzi C.F. … Wainberg M.A. (AIDS 2007) 3 23
  4. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. (PMID: 18079182) Hyllus D. … Bauer U.M. (Genes Dev. 2007) 3 23
  5. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. (PMID: 16293633) Sgarra R. … Manfioletti G. (J. Biol. Chem. 2006) 3 23

Products for PRMT6 Gene

Sources for PRMT6 Gene

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