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PRMT5 Gene

protein-coding   GIFtS: 62
GCID: GC14M023389

Protein Arginine Methyltransferase 5

(Previous names: skb1 (S. pombe) homolog, SKB1 homolog (S. pombe))
(Previous symbols: HRMT1L5, SKB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 51 2     SKB1Hs2 3
HRMT1L51 2 3     SKB1 Homolog2 3
SKB11 2 3     Skb1 (S. Pombe) Homolog1
Histone-Arginine N-Methyltransferase PRMT52 3     SKB1 Homolog (S. Pombe)1
Jak-Binding Protein 12 3     HMT1 HnRNP Methyltransferase-Like 52
Shk1 Kinase-Binding Protein 1 Homolog2 3     Protein Arginine N-Methyltransferase 52
72 KDa ICln-Binding Protein2 3     EC 2.1.1.-3
IBP722 3     EC 2.1.1.1253
JBP12 3     

External Ids:    HGNC: 108941   Entrez Gene: 104192   Ensembl: ENSG000001004627   OMIM: 6040455   UniProtKB: O147443   

Export aliases for PRMT5 gene to outside databases

Previous GC identifers: GC14M022460 GC14M003506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRMT5 Gene:
PRMT5 (protein arginine methyltransferase 5) is a protein-coding gene. Diseases associated with PRMT5 include leukemia/lymphoma, t-cell, and mantle cell lymphoma. GO annotations related to this gene include chromatin binding and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot: ANM5_HUMAN, O14744
Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
(SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates
SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the
assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively
regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional
elongation properties. May be part of a pathway that is connected to a chloride current, possibly through
cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates
histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4),
methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and
subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3
pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6
recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence
destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of
E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates
and regulates SRGAP2 which is involved in cell migration and differentiation

Gene Wiki entry for PRMT5 (Protein arginine methyltransferase 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT5 gene promoter:
         HOXA9B   HOXA9   Tal-1   MyoD   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Meis-1b   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT5 promoter sequence
   Search Chromatin IP Primers for PRMT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

PRMT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023389:  view genomic region     (about GC identifiers)

Start:
23,389,720 bp from pter      End:
23,398,794 bp from pter
Size:
9,075 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANM5_HUMAN, O14744 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 5  
Size: 637 amino acids; 72684 Da
Subunit: Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the
methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1 and WDR77/MEP50. Interacts with EGFR;
methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found
in a complex with COPRS, RUNX1 AND CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP,
but seems to require the presence of PRMT1 (By similarity). Interacts with EPB41L3; this modulates methylation of
target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor
complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2,
SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPRS; promoting
its recruitment on histone H4. Interacts with CLNS1A/pICln. Identified in a complex with CLNS1A/pICln and Sm
proteins. Interacts with RPS10. Interacts with WDR77. Interacts with IWS1
1 PDB 3D structure from and Proteopedia for PRMT5:
4GQB (3D)    
Secondary accessions: A8MZ91 B5BU10 D3DS33 Q6IBR1 Q9UKH1
Alternative splicing: 2 isoforms:  O14744-1   O14744-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT5: NX_O14744

Explore proteomics data for PRMT5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys60, Lys85, Lys95, Lys227, Lys490
  • Modification sites at PhosphoSitePlus

  • See PRMT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001034708.1  NP_001269882.1  NP_001269883.1  NP_001269884.1  NP_001269885.1  NP_006100.2  

    ENSEMBL proteins: 
     ENSP00000319169   ENSP00000380583   ENSP00000452501   ENSP00000380582   ENSP00000216350  
     ENSP00000451245   ENSP00000387663   ENSP00000451127   ENSP00000452555   ENSP00000450956  
     ENSP00000452409   ENSP00000452509   ENSP00000450737   ENSP00000452102   ENSP00000452218  
     ENSP00000450633   ENSP00000450919   ENSP00000452411   ENSP00000409482   ENSP00000444915  
    Reactome Protein details: O14744

    PRMT5 Human Recombinant Protein Products:

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    Novus Biologicals PRMT5 Proteins
    Novus Biologicals PRMT5 Lysates
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    Sino Biological Cell Lysate for PRMT5
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    Cloud-Clone Corp. Proteins for PRMT5

    PRMT5 Antibody Products:

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    PRMT5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRMT5
    Cloud-Clone Corp. CLIAs for PRMT5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT5
    Protein arginine N-methyltransferases

    2 InterPro protein domains:
     IPR007857 Arg_MeTrfase_PRMT5
     IPR025799 Arg_MeTrfase

    Graphical View of Domain Structure for InterPro Entry O14744

    ProtoNet protein and cluster: O14744

    1 Blocks protein domain: IPB007857 Skb1 methyltransferase

    UniProtKB/Swiss-Prot: ANM5_HUMAN, O14744
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain


    PRMT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM5_HUMAN, O14744
    Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and
    symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the
    symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3
    (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates
    SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the
    assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively
    regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional
    elongation properties. May be part of a pathway that is connected to a chloride current, possibly through
    cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates
    histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4),
    methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and
    subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3
    pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6
    recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence
    destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of
    E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates
    and regulates SRGAP2 which is involved in cell migration and differentiation
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Enzyme regulation: Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF
    treatment

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.1.1251

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI16087681
    GO:0008168methyltransferase activity IDA15369763
    GO:0008469histone-arginine N-methyltransferase activity IBA--
    GO:0035243protein-arginine omega-N symmetric methyltransferase activity IMP17709427
         
    PRMT5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRMT5:
     Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prmt5):
     behavior/neurological  cellular  embryogenesis  growth/size/body  integument 
     mortality/aging  nervous system 

    PRMT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRMT5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRMT5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRMT5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRMT5

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRMT5:
    hsa-mir-346 (MIRT042720), hsa-mir-92b-3p (MIRT004351), hsa-mir-25-3p (MIRT000983), hsa-mir-96-5p (MIRT004352), hsa-mir-320a (MIRT044499), hsa-mir-32-5p (MIRT000982), hsa-mir-19a-3p (MIRT004350)

    Block miRNA regulation of human, mouse, rat PRMT5 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PRMT5:
    hsa-miR-3149 hsa-miR-1233 hsa-miR-1266 hsa-miR-2115 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidPRMT5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRMT5
    Predesigned siRNA for gene silencing in human, mouse, rat PRMT5

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for PRMT5 (see all 11)
    OriGene ORF clones in mouse, rat for PRMT5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT5 (NM_006109)
    Sino Biological Human cDNA Clone for PRMT5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PRMT5
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM5_HUMAN, O14744: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS18404153
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0034709methylosome IDA18984161
    GO:0043234protein complex ----

    PRMT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRMT5 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2Gene Expression
    Gene Expression0.40
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4RNA transport
    RNA transport
    5p53 pathway
    p53 pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRMT5
        Chromatin Regulation / Acetylation

    3 BioSystems Pathways for PRMT5
        E2F transcription factor network
    Signaling events mediated by HDAC Class I
    p53 pathway


    1 Reactome Pathway for PRMT5
        snRNP Assembly


    1 Kegg Pathway  (Kegg details for PRMT5):
        RNA transport


    PRMT5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT5: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRMT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRMT5 (O147441, 2, 3 ENSP000003191694) via UniProtKB, MINT, STRING, and/or I2D (see all 451)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628051, 2, 3, ENSP000003529804EBI-351098,EBI-302023 MINT-56509 I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628051, 2, 3, ENSP000003482584EBI-351098,EBI-302023 MINT-56509 I2D: score=3 STRING: ENSP00000348258
    HIST1H4BP628051, 2, 3EBI-351098,EBI-302023 MINT-56509 I2D: score=3 
    HIST1H4CP628051, 2, 3EBI-351098,EBI-302023 MINT-56509 I2D: score=3 
    HIST1H4DP628051, 2, 3EBI-351098,EBI-302023 MINT-56509 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006479protein methylation ----

    PRMT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT5 (ANM5)

    4 HMDB Compounds for PRMT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Cob(II)alaminVitamin B12r (see all 5)14463-33-3--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    2 Novoseek inferred chemical compound relationships for PRMT5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 72.6 46 17437848 (7), 17974993 (3), 11413150 (2), 19086919 (2) (see all 20)
    testosterone 0.167 2 17437848 (2)



    PRMT5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for PRMT5 gene (6 alternative transcripts): 
    NM_001039619.2  NM_001282953.1  NM_001282954.1  NM_001282955.1  NM_001282956.1  NM_006109.4  

    Unigene Cluster for PRMT5:

    Protein arginine methyltransferase 5
    Hs.367854  [show with all ESTs]
    Unigene Representative Sequence: NM_001039619
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000324366(uc001whm.1 uc010tnh.1) ENST00000397441(uc001whl.1 uc010tnf.1 uc010tng.1 uc001whn.1)
    ENST00000557443 ENST00000476175 ENST00000397440 ENST00000216350 ENST00000555454
    ENST00000454731 ENST00000553915 ENST00000553897 ENST00000557758 ENST00000553502
    ENST00000555530 ENST00000556043 ENST00000553550 ENST00000554716 ENST00000553787
    ENST00000553641
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    SwitchGear 3'UTR luciferase reporter plasmidPRMT5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT5 (NM_006109)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PRMT5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRMT5
      QuantiTect SYBR Green Assays in human, mouse, rat PRMT5
      QuantiFast Probe-based Assays in human, mouse, rat PRMT5

    Additional mRNA sequence: 

    AB451246.1 AB451370.1 AF015913.1 AF167572.1 AK027737.1 AK075251.1 AK300863.1 AK301812.1 
    AK302240.1 AK315500.1 AL833612.1 BC005820.2 BC025979.2 CR456741.1 

    Selected DOTS entries (see all 35):

    DT.443547  DT.101969883  DT.120777773  DT.100709939  DT.100681614  DT.100649367  DT.100681617  DT.120777844 
    DT.100681609  DT.100030872  DT.120777751  DT.100857670  DT.120777544  DT.120777507  DT.97855476  DT.95366575 
    DT.85100215  DT.95366561  DT.95366580  DT.95366583  DT.97855479  DT.100847465  DT.100658420  DT.100694208 

    Selected AceView cDNA sequences (see all 575):

    BM452271 BM752460 BM788566 AK075251 CB157151 CB153206 BG760811 BF983212 
    BU184908 BM718489 BF954738 CR624259 BM757708 CD673722 AW160491 AW779827 
    BM698643 BQ646843 BM749431 AW439883 BM822069 BX347527 AA330136 AL043891 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRMT5 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
    SP1:                                      -     -                                                           -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                                      -     -                                   -     -     -     -     -     -                                             
    SP4:                                      -     -                       -     -     -     -     -     -     -     -                                             
    SP5:                                      -     -     -                                                     -                                                   

    ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PRMT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRMT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTTGAAC
    PRMT5 Expression
    About this image


    PRMT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    PRMT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367854

    UniProtKB/Swiss-Prot: ANM5_HUMAN, O14744
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT5: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt51 , 5 protein arginine N-methyltransferase 51, 5 91.69(n)1
    97.92(a)1
      14 (27.82 cM)5
    273741  NM_013768.31  NP_038796.21 
     545071875 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT56
    protein arginine methyltransferase 5
    82(a)
    1 ↔ 1
    GL343879.1(52516-75894)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX846887.12   -- 75.7(n)    BX846887.1 
    zebrafish
    (Danio rerio)
    Actinopterygii skb12 SKB1 homolog (S. pombe) 77.84(n)   368664  57044391 
    fruit fly
    (Drosophila melanogaster)
    Insecta csul1 capsuleen 51.02(n)
    42.83(a)
      36809  NM_166158.1  NP_725552.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prmt-56
    Protein PRMT-5 (prmt-5) mRNA, complete cds
    30(a)
    1 ↔ 1
    III(5230555-5234607) WBGene00016408
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSL7(YBR133C)4 Protein arginine N-methyltransferase that exhibits more   --   2(504287-501804) 852431  NP_009691.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKB11 SKB1 54.54(n)
    50.34(a)
      829240  NM_119262.5  NP_194841.2 
    rice
    (Oryza sativa)
    Liliopsida Os.177722 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.38(n)    AK103804.1 


    ENSEMBL Gene Tree for PRMT5 (if available)
    TreeFam Gene Tree for PRMT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT5 gene

    PRMT5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRMT5
    PGOHUM00000261903


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRMT5 (see all 223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841021071,2
    C--23393188(+) ATCACA/CCTCCA 2 -- int10--------
    rs1887816381,2
    C--23393435(+) GAAATC/TTGGCA 2 -- int10--------
    rs2001212681,2
    C--23393447(+) TGAGGA/GCTAAC 2 -- int10--------
    rs1504204781,2
    C--23393548(+) CTGCCC/TGCAGG 4 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1491768391,2
    F--23393716(+) TTCTGG/ATACTC 4 /P /S mis11Minor allele frequency- A:0.00NA 4552
    rs2017108281,2
    --23393792(+) CTCCCC/TAGGTC 2 -- int10--------
    rs101442681,2
    H--23393819(+) TTCCTC/TACCCT 2 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1152448731,2
    C,F--23393856(+) TGAGAG/ATATTT 4 /Y syn12Minor allele frequency- A:0.00WA NA 4770
    rs779385911,2
    C,F--23393969(+) GACAAT/CGCACT 2 -- int13Minor allele frequency- C:0.10CSA WA 122
    rs1808729841,2
    --23393994(+) TTTCCA/GCTGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRMT5 (23389720 - 23398794 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRMT5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRMT5
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604045    OMIM disorders: --

    16 diseases for PRMT5:    
    About MalaCards
    leukemia/lymphoma, t-cell    mantle cell lymphoma    germ cell tumors    kaposi's sarcoma
    sarcoma    hypoxia    ovarian cancer    tonsillitis
    prostatitis    endotheliitis    prostate cancer    lung cancer
    leukemia    thyroiditis    malaria    cerebritis


    PRMT5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PRMT5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 3.92 5 17627275 (2)


    Export disorders for PRMT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT5 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with PRMT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. (PubMed id 9843966)1, 2, 3 Gilbreth M.... Marcus S. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. (PubMed id 11152681)1, 2, 9 Rho J.... Im D.-S. (J. Biol. Chem. 2001)
    3. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. (PubMed id 18404153)1, 2, 9 Lacroix M....Fabbrizio E. (EMBO Rep. 2008)
    4. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. (PubMed id 10531356)1, 2, 9 Pollack B.P....Pestka S. (J. Biol. Chem. 1999)
    5. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PubMed id 17709427)1, 2, 9 Gonsalvez G.B....Matera A.G. (J. Cell Biol. 2007)
    6. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PubMed id 16087681)1, 2, 9 Azzouz T.N.... Schuemperli D. (J. Biol. Chem. 2005)
    7. Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. (PubMed id 12718890)1, 2, 9 Kwak Y.T.... Gaynor R.B. (Mol. Cell 2003)
    8. Crystal structure of the human PRMT5:MEP50 complex. (PubMed id 23071334)1, 2 Antonysamy S....Emtage S. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules. (PubMed id 22269951)1, 2 Bandyopadhyay S.... Dicorleto P.E. (Mol. Cell. Biol. 2012)
    10. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. (PubMed id 21917714)1, 2 Andreu-Perez P.... Recio J.A. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10419 HGNC: 10894 AceView: SKB1 Ensembl:ENSG00000100462 euGenes: HUgn10419
    ECgene: PRMT5 Kegg: 10419 H-InvDB: PRMT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRMT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRMT5 gene:
    Search GeneIP for patents involving PRMT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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