Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRMT5 Gene

Aliases for PRMT5 Gene

  • Protein Arginine Methyltransferase 5 2 3 5
  • Histone-Arginine N-Methyltransferase PRMT5 3 4
  • Shk1 Kinase-Binding Protein 1 Homolog 3 4
  • 72 KDa ICln-Binding Protein 3 4
  • Jak-Binding Protein 1 3 4
  • SKB1 Homolog 3 4
  • HRMT1L5 3 4
  • SKB1Hs 3 4
  • IBP72 3 4
  • SKB1 3 4
  • JBP1 3 4
  • Protein Arginine N-Methyltransferase 5 3
  • HMT1 HnRNP Methyltransferase-Like 5 3
  • Skb1 (S. Pombe) Homolog 2
  • SKB1 Homolog (S. Pombe) 2
  • EC 2.1.1.320 4

External Ids for PRMT5 Gene

Previous HGNC Symbols for PRMT5 Gene

  • HRMT1L5
  • SKB1

Previous GeneCards Identifiers for PRMT5 Gene

  • GC14M022460
  • GC14M023389
  • GC14M003506

Summaries for PRMT5 Gene

Entrez Gene Summary for PRMT5 Gene

  • This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

GeneCards Summary for PRMT5 Gene

PRMT5 (Protein Arginine Methyltransferase 5) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and Regulation of TP53 Activity. GO annotations related to this gene include protein heterodimerization activity and transcription corepressor activity.

UniProtKB/Swiss-Prot for PRMT5 Gene

  • Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 Arg-3 during germ cell development. Methylates histone H3 Arg-8, which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR Tyr-1197 phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).

Tocris Summary for PRMT5 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT5 Gene

Genomics for PRMT5 Gene

Regulatory Elements for PRMT5 Gene

Enhancers for PRMT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022976 1.9 FANTOM5 ENCODE dbSUPER 37.5 -50.3 -50321 7.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 MMP14 PSMB5 C14orf119 CDH24 C14orf93 PSMB11 PABPN1
GH14G022994 1.3 Ensembl ENCODE dbSUPER 32.7 -65.3 -65283 1.1 ELF3 CTCF SAP130 TEAD4 ARID4B ZIC2 ZNF48 RAD21 TEAD3 ZFHX2 PRMT5 CDH24 PSMB5 PSMB11 ACIN1 GC14P023988 ENSG00000280129
GH14G022884 1.6 FANTOM5 Ensembl ENCODE 16.8 +42.7 42731 4.3 HDGF PKNOX1 ARNT AGO1 SIN3A ZNF766 ZNF143 SP3 REST TBX21 PRMT5 HAUS4 MMP14 SLC7A7 MRPL52 ABHD4 CDH24 RBM23 REM2 PRMT5-AS1
GH14G022504 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +391.4 391398 66.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 MMP14 ABHD4 OXA1L EFS BCL2L2-PABPN1 DAD1 LOC105370399 TRAC C14orf119 OR6J1
GH14G022921 0.6 ENCODE 30.5 +7.5 7521 1.5 FOSL1 PKNOX1 EGR1 PBX2 FOS ZBTB33 HAUS4 PRMT5 RBM23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRMT5 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066664 -215 2401 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC

Genomic Location for PRMT5 Gene

Chromosome:
14
Start:
22,920,511 bp from pter
End:
22,929,585 bp from pter
Size:
9,075 bases
Orientation:
Minus strand

Genomic View for PRMT5 Gene

Genes around PRMT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT5 Gene

Proteins for PRMT5 Gene

  • Protein details for PRMT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14744-ANM5_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 5
    Protein Accession:
    O14744
    Secondary Accessions:
    • A8MTP3
    • A8MZ91
    • B4DX49
    • B4DY30
    • B5BU10
    • D3DS33
    • E2QRE7
    • Q6IBR1
    • Q9UKH1

    Protein attributes for PRMT5 Gene

    Size:
    637 amino acids
    Molecular mass:
    72684 Da
    Quaternary structure:
    • Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH. Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 AND CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (PubMed:25284789). Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln. Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10. Interacts with WDR77. Interacts with IWS1. Interacts with CRY1. Interacts with POLR2A. Interacts with SMN1/SMN2.
    SequenceCaution:
    • Sequence=BC005820; Type=Frameshift; Positions=370; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT5 Gene

    Alternative splice isoforms for PRMT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT5 Gene

Post-translational modifications for PRMT5 Gene

  • Ubiquitination at isoforms=2, 3, 4, 560, isoforms=2, 485, isoforms=2, 495, Lys227, and Lys490
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT5 (PRMT5)
  • Abcam antibodies for PRMT5

No data available for DME Specific Peptides for PRMT5 Gene

Domains & Families for PRMT5 Gene

Gene Families for PRMT5 Gene

Protein Domains for PRMT5 Gene

Graphical View of Domain Structure for InterPro Entry

O14744

UniProtKB/Swiss-Prot:

ANM5_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT5: view

Function for PRMT5 Gene

Molecular function for PRMT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 Arg-3 during germ cell development. Methylates histone H3 Arg-8, which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR Tyr-1197 phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).

Enzyme Numbers (IUBMB) for PRMT5 Gene

Gene Ontology (GO) - Molecular Function for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003714 transcription corepressor activity ISS --
GO:0005515 protein binding IPI 11756452
GO:0008168 methyltransferase activity IEA,IDA 15369763
GO:0008327 methyl-CpG binding IDA 25284789
genes like me logo Genes that share ontologies with PRMT5: view
genes like me logo Genes that share phenotypes with PRMT5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRMT5 Gene

Localization for PRMT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT5 Gene

Cytoplasm. Nucleus. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT5 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 18404153
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 22952863
GO:0005794 Golgi apparatus IEA,IDA 20421892
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with PRMT5: view

Pathways & Interactions for PRMT5 Gene

genes like me logo Genes that share pathways with PRMT5: view

Pathways by source for PRMT5 Gene

1 GeneTex pathway for PRMT5 Gene
1 Cell Signaling Technology pathway for PRMT5 Gene

SIGNOR curated interactions for PRMT5 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006353 DNA-templated transcription, termination IMP 26700805
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006479 protein methylation IEA --
genes like me logo Genes that share ontologies with PRMT5: view

Drugs & Compounds for PRMT5 Gene

(5) Drugs for PRMT5 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
EPZ015666 Pharma PRMT5 inhibitor 0

(2) Additional Compounds for PRMT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
cob(ii)alamin
  • Co(I)-Cobalamine
  • Cob(2)alamin
  • Cob(II)alamin
  • Cobinamide-Co(1+)
  • Vitamin B12r
14463-33-3

(1) ApexBio Compounds for PRMT5 Gene

Compound Action Cas Number
EPZ015666 PRMT5 inhibitor 1616391-65-1
genes like me logo Genes that share compounds with PRMT5: view

Drug Products

Transcripts for PRMT5 Gene

Unigene Clusters for PRMT5 Gene

Protein arginine methyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - -
SP13: - - -
SP14:
SP15: - - - - - - - - - - - - - - - - - - -
SP16:
SP17: - - - - -
SP18: - -
SP19:

ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PRMT5 Gene

GeneLoc Exon Structure for
PRMT5
ECgene alternative splicing isoforms for
PRMT5

Expression for PRMT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRMT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRMT5 Gene

This gene is overexpressed in Lymph node (9.6) and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRMT5 Gene



Protein tissue co-expression partners for PRMT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRMT5 Gene:

PRMT5

SOURCE GeneReport for Unigene cluster for PRMT5 Gene:

Hs.367854

mRNA Expression by UniProt/SwissProt for PRMT5 Gene:

O14744-ANM5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PRMT5 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Blood(4.3)
  • Thyroid gland(4.3)
  • Liver(3.7)
  • Kidney(3.3)
  • Lung(3.3)
  • Intestine(2.8)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with PRMT5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT5 Gene

Orthologs for PRMT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT5 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia PRMT5 34 35
  • 94.3 (n)
oppossum
(Monodelphis domestica)
Mammalia PRMT5 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRMT5 34 35
  • 93.56 (n)
mouse
(Mus musculus)
Mammalia Prmt5 34 16 35
  • 91.69 (n)
rat
(Rattus norvegicus)
Mammalia Prmt5 34
  • 91.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT5 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT5 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt5 34
  • 73.96 (n)
Str.6690 34
zebrafish
(Danio rerio)
Actinopterygii prmt5 34 35
  • 72.06 (n)
skb1 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009048 34
  • 51.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta csul 34 35
  • 51.02 (n)
worm
(Caenorhabditis elegans)
Secernentea prmt-5 35
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSL7 35 37
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SKB1 34
  • 54.54 (n)
rice
(Oryza sativa)
Liliopsida Os02g0139200 34
  • 54.85 (n)
Os.17772 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2107 34
Species where no ortholog for PRMT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT5 Gene

ENSEMBL:
Gene Tree for PRMT5 (if available)
TreeFam:
Gene Tree for PRMT5 (if available)

Paralogs for PRMT5 Gene

Pseudogenes.org Pseudogenes for PRMT5 Gene

genes like me logo Genes that share paralogs with PRMT5: view

No data available for Paralogs for PRMT5 Gene

Variants for PRMT5 Gene

Sequence variations from dbSNP and Humsavar for PRMT5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000364140 -- 22,928,873(+) CTCCT(C/G)AGGTG intron-variant, upstream-variant-2KB
rs1000947209 -- 22,920,194(+) TTCCC(A/G)AGAGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1001102865 -- 22,929,762(+) GACTC(C/T)TGGCT intron-variant, upstream-variant-2KB
rs1001244882 -- 22,921,781(+) GGAGG(C/T)TGAGG intron-variant
rs1001981358 -- 22,923,356(+) CCACT(A/G)CTAGG intron-variant, nc-transcript-variant

Variation tolerance for PRMT5 Gene

Residual Variation Intolerance Score: 8.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRMT5 Gene

Disorders for PRMT5 Gene

Relevant External Links for PRMT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT5

No disorders were found for PRMT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRMT5 Gene

Publications for PRMT5 Gene

  1. Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. (PMID: 20159986) Ren J. … Xu Z. (J. Biol. Chem. 2010) 3 4 22 64
  2. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. (PMID: 18404153) Lacroix M. … Fabbrizio E. (EMBO Rep. 2008) 3 4 22 64
  3. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PMID: 17709427) Gonsalvez G.B. … Matera A.G. (J. Cell Biol. 2007) 3 4 22 64
  4. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PMID: 16087681) Azzouz T.N. … Schuemperli D. (J. Biol. Chem. 2005) 3 4 22 64
  5. Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. (PMID: 12718890) Kwak Y.T. … Gaynor R.B. (Mol. Cell 2003) 3 4 22 64

Products for PRMT5 Gene

Sources for PRMT5 Gene

Content
Loading form....