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Aliases for PRMT5 Gene

Aliases for PRMT5 Gene

  • Protein Arginine Methyltransferase 5 2 3
  • Histone-Arginine N-Methyltransferase PRMT5 3 4
  • Shk1 Kinase-Binding Protein 1 Homolog 3 4
  • 72 KDa ICln-Binding Protein 3 4
  • Jak-Binding Protein 1 3 4
  • SKB1 Homolog 3 4
  • HRMT1L5 3 4
  • SKB1Hs 3 4
  • IBP72 3 4
  • SKB1 3 4
  • JBP1 3 4
  • Protein Arginine N-Methyltransferase 5 3
  • HMT1 HnRNP Methyltransferase-Like 5 3
  • Skb1 (S. Pombe) Homolog 2
  • SKB1 Homolog (S. Pombe) 2
  • EC 2.1.1.125 4
  • EC 2.1.1.- 4

External Ids for PRMT5 Gene

Previous HGNC Symbols for PRMT5 Gene

  • HRMT1L5
  • SKB1

Previous GeneCards Identifiers for PRMT5 Gene

  • GC14M022460
  • GC14M023389
  • GC14M003506

Summaries for PRMT5 Gene

GeneCards Summary for PRMT5 Gene

PRMT5 (Protein Arginine Methyltransferase 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for PRMT5 Gene

  • Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 Arg-3 during germ cell development. Methylates histone H3 Arg-8, which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR Tyr-1197 phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter.

Gene Wiki entry for PRMT5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT5 Gene

Genomics for PRMT5 Gene

Regulatory Elements for PRMT5 Gene

Genomic Location for PRMT5 Gene

Start:
22,920,511 bp from pter
End:
22,929,585 bp from pter
Size:
9,075 bases
Orientation:
Minus strand

Genomic View for PRMT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRMT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT5 Gene

Proteins for PRMT5 Gene

  • Protein details for PRMT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14744-ANM5_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 5
    Protein Accession:
    O14744
    Secondary Accessions:
    • A8MTP3
    • A8MZ91
    • B4DX49
    • B4DY30
    • B5BU10
    • D3DS33
    • E2QRE7
    • Q6IBR1
    • Q9UKH1

    Protein attributes for PRMT5 Gene

    Size:
    637 amino acids
    Molecular mass:
    72684 Da
    Quaternary structure:
    • Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1 and WDR77/MEP50. Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 AND CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (By similarity). Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln. Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10. Interacts with WDR77. Interacts with IWS1. Interacts with CRY1.
    SequenceCaution:
    • Sequence=BC005820; Type=Frameshift; Positions=370; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRMT5 Gene

    Alternative splice isoforms for PRMT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT5 Gene

Proteomics data for PRMT5 Gene at MOPED

Post-translational modifications for PRMT5 Gene

  • Ubiquitination at Lys60, Lys85, Lys95, Lys227, and Lys490
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT5 (PRMT5)

No data available for DME Specific Peptides for PRMT5 Gene

Domains for PRMT5 Gene

Gene Families for PRMT5 Gene

HGNC:
  • PRMT :Protein arginine methyltransferases
IUPHAR :

Protein Domains for PRMT5 Gene

Graphical View of Domain Structure for InterPro Entry

O14744

UniProtKB/Swiss-Prot:

ANM5_HUMAN :
  • O14744
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT5: view

Function for PRMT5 Gene

Molecular function for PRMT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.
UniProtKB/Swiss-Prot Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 Arg-3 during germ cell development. Methylates histone H3 Arg-8, which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR Tyr-1197 phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter.

Enzyme Numbers (IUBMB) for PRMT5 Gene

Gene Ontology (GO) - Molecular Function for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity ISS --
GO:0005515 protein binding IPI 16087681
GO:0008168 methyltransferase activity IDA 15369763
genes like me logo Genes that share ontologies with PRMT5: view
genes like me logo Genes that share phenotypes with PRMT5: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRMT5 Gene

Localization for PRMT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT5 Gene COMPARTMENTS Subcellular localization image for PRMT5 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 18404153
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0034709 methylosome IDA 18984161
genes like me logo Genes that share ontologies with PRMT5: view

Pathways for PRMT5 Gene

genes like me logo Genes that share pathways with PRMT5: view

Pathways by source for PRMT5 Gene

1 Cell Signaling Technology pathway for PRMT5 Gene
3 Reactome pathways for PRMT5 Gene
1 KEGG pathway for PRMT5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with PRMT5: view

Compounds for PRMT5 Gene

(4) HMDB Compounds for PRMT5 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Cob(II)alamin
  • Vitamin B12r
14463-33-3
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(2) Novoseek inferred chemical compound relationships for PRMT5 Gene

Compound -log(P) Hits PubMed IDs
arginine 72.6 33
testosterone 0.167 2
genes like me logo Genes that share compounds with PRMT5: view

Transcripts for PRMT5 Gene

Unigene Clusters for PRMT5 Gene

Protein arginine methyltransferase 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRMT5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - - - -
SP13: - - -
SP14:
SP15: - - - - - - - - - - - - - - - - - - -
SP16:
SP17: - - - - -
SP18: - -
SP19:

ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:

Relevant External Links for PRMT5 Gene

GeneLoc Exon Structure for
PRMT5
ECgene alternative splicing isoforms for
PRMT5

Expression for PRMT5 Gene

mRNA expression in normal human tissues for PRMT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRMT5 Gene

SOURCE GeneReport for Unigene cluster for PRMT5 Gene Hs.367854

mRNA Expression by UniProt/SwissProt for PRMT5 Gene

O14744-ANM5_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PRMT5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRMT5 Gene

Orthologs for PRMT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT5 35
  • 99.79 (n)
  • 100 (a)
PRMT5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRMT5 35
  • 93.56 (n)
  • 99.22 (a)
PRMT5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT5 35
  • 94.3 (n)
  • 99.37 (a)
PRMT5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt5 35
  • 91.69 (n)
  • 97.92 (a)
Prmt5 16
Prmt5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRMT5 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT5 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prmt5 35
  • 91.64 (n)
  • 97.76 (a)
lizard
(Anolis carolinensis)
Reptilia PRMT5 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt5 35
  • 73.96 (n)
  • 84.35 (a)
Str.6690 35
zebrafish
(Danio rerio)
Actinopterygii prmt5 35
  • 72.06 (n)
  • 79.17 (a)
prmt5 36
  • 79 (a)
OneToOne
skb1 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009048 35
  • 51.96 (n)
  • 45.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta csul 35
  • 51.02 (n)
  • 42.83 (a)
csul 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prmt-5 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSL7 36
  • 23 (a)
OneToOne
HSL7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SKB1 35
  • 54.54 (n)
  • 50.34 (a)
rice
(Oryza sativa)
Liliopsida Os.17772 35
Os02g0139200 35
  • 54.85 (n)
  • 50.84 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2107 35
Species with no ortholog for PRMT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT5 Gene

ENSEMBL:
Gene Tree for PRMT5 (if available)
TreeFam:
Gene Tree for PRMT5 (if available)

Paralogs for PRMT5 Gene

Pseudogenes.org Pseudogenes for PRMT5 Gene

genes like me logo Genes that share paralogs with PRMT5: view

No data available for Paralogs for PRMT5 Gene

Variants for PRMT5 Gene

Sequence variations from dbSNP and Humsavar for PRMT5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1956880 -- 22,924,798(+) CTGAG(C/T)TTTAG intron-variant
rs1956881 -- 22,924,860(+) CCTCT(A/C)AGTGC intron-variant
rs4982709 -- 22,925,490(+) CAATA(C/T)CAACA intron-variant
rs8005846 -- 22,927,014(+) TCCAA(A/G)ATAAT intron-variant
rs8006409 -- 22,927,302(+) ACAGG(A/G)TTTCA intron-variant

Relevant External Links for PRMT5 Gene

HapMap Linkage Disequilibrium report
PRMT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRMT5 Gene

Disorders for PRMT5 Gene

(1) Novoseek inferred disease relationships for PRMT5 Gene

Disease -log(P) Hits PubMed IDs
cancer 3.92 2
genes like me logo Genes that share disorders with PRMT5: view

No data available for UniProtKB/Swiss-Prot for PRMT5 Gene

Publications for PRMT5 Gene

  1. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. (PMID: 10531356) Pollack B.P. … Pestka S. (J. Biol. Chem. 1999) 3 4 23
  2. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. (PMID: 11152681) Rho J. … Im D.-S. (J. Biol. Chem. 2001) 3 4 23
  3. Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. (PMID: 12718890) Kwak Y.T. … Gaynor R.B. (Mol. Cell 2003) 3 4 23
  4. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PMID: 16087681) Azzouz T.N. … Schuemperli D. (J. Biol. Chem. 2005) 3 4 23
  5. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PMID: 17709427) Gonsalvez G.B. … Matera A.G. (J. Cell Biol. 2007) 3 4 23

Products for PRMT5 Gene

Sources for PRMT5 Gene

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