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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRMT3 Gene

protein-coding   GIFtS: 59
GCID: GC11P020373

protein arginine methyltransferase 3

(Previous name: HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) )
(Previous symbol: HRMT1L3)
 Explore 3 diseases affiliated with
PRMT3 via our new
 Human Malady Compendium 
Biological research products
for PRMT3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Protein Arginine Methyltransferase 31 2     HMT1 HnRNP Methyltransferase-Like 32
HRMT1L31 2 3     Protein Arginine N-Methyltransferase 32
Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 32 3     EC 2.1.1.-3
HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae)1     EC 2.1.18
Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like 32     

External Ids:    HGNC: 301631   Entrez Gene: 101962   Ensembl: ENSG000001852387   OMIM: 6031905   UniProtKB: O606783   

Export aliases for PRMT3 gene to outside databases

Previous GC identifers: GC11M021595 GC11U900019 GC11P020448 GC11P020092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRMT3:
Type I protein arginine N-methyltransferases (PRMTs), such as PRMT3, catalyze the formation of asymmetric
N(G),N(G)-dimethylarginine (ADMA) residues in proteins (Tang et al., 1998 (PubMed 9642256)).(supplied by OMIM, Mar
2008)

UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678
Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins

Gene Wiki entry for PRMT3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRMT3 gene promoter:
         TBP   AML1a   POU6F1 (c2)   NF-E2 p45   HNF-1A   N-Myc   HNF-1   TFIID   LHX3a/Lhx3a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRMT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

PRMT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P020373:  view genomic region     (about GC identifiers)

Start:
20,409,076 bp from pter      End:
20,530,879 bp from pter
Size:
121,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 3  
Size: 531 amino acids; 59876 Da
Subunit: May exist as a monomer or homodimer (By similarity)
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for PRMT3:
2FYT (3D)        3SMQ (3D)        4HSG (3D)    
Secondary accessions: B4DUC7
Alternative splicing: 2 isoforms:  O60678-1   O60678-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT3: NX_O60678

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60678

  • 4/9 DME Specific Peptides for PRMT3 (O60678) (see all 9)
     KVVLDVG  HEEMLKD  GIHEEML  VLDVGCG 

    PRMT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138638.1  NP_001138639.1  NP_005779.1  

    ENSEMBL proteins: 
     ENSP00000331879   ENSP00000329586   ENSP00000435151   ENSP00000397766   ENSP00000434260  

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    Uscn Proteins for PRMT3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS9642256
    GO:0005829cytosol IEA--
    GO:0005840ribosome IEA--


    PRMT3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PRMT3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PRMT3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O60678

    ProtoNet protein and cluster: O60678

    1 Blocks protein family: IPB013216 Methyltransferase type 11

    UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678
    Domain: The zinc-finger is responsible for substrate specificity (By similarity)
    Similarity: Belongs to the protein arginine N-methyltransferase family
    Similarity: Contains 1 C2H2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678
    Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins
    Enzyme regulation: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride (By similarity)

    Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PRMT3:
    hsa-miR-3163 hsa-miR-607 hsa-miR-548am hsa-miR-548x hsa-miR-648 hsa-miR-4282 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPRMT3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016274protein-arginine N-methyltransferase activity NAS9642256
    GO:0035242protein-arginine omega-N asymmetric methyltransferase activity IEA--


    PRMT3 for ontologies           About GeneDecksing


    Animal Models:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prmt3):
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  skeleton  vision/eye 

    PRMT3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRMT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for PRMT3 (O606782, 3 ENSP000003318794) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPKP619782, 3, ENSP000003654394MINT-6803896 I2D: score=1 STRING: ENSP00000365439
    FBLP220873, ENSP000002218014I2D: score=1 STRING: ENSP00000221801
    PABPN1Q86U423, ENSP000002167274I2D: score=1 STRING: ENSP00000216727
    RPS2P158803, ENSP000003418854I2D: score=1 STRING: ENSP00000341885
    C12orf44Q9BSB43I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006479protein methylation ----
    GO:0008150biological_process ND--
    GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ----
    GO:0035246peptidyl-arginine N-methylation ----


    PRMT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRMT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PRMT3:
    Small Molecule - inhibitor
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    Browse Tocris compounds for PRMT3

    10/12 HMDB Compounds for PRMT3 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistidine1 methylhistidine (see all 9)332-80-91446680
    2-HydroxyestradiolEstra-1,3,5(10)-triene-2,3,17b-triol (see all 15)362-05-0--
    2-Methoxyestradiol2-Methoxyestradiol 362-07-2--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--
    ChlorineCl2 (see all 13)16887-00-6--
    Hordenine4-(2-Dimethylaminoethyl)phenol (see all 16)539-15-1--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    N-Methyltyramine{p-[2-(Methylamino)ethyl]phenol} (see all 12)370-98-9--
    Se-Adenosylselenohomocysteine ----

    1 DrugBank Compound for PRMT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235

    1 Novoseek chemical compound relationship for PRMT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 66.8 19 15334060 (3), 15473865 (2), 16190779 (1), 10931850 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about PRMT3 / ANM3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRMT3 gene (3 alternative transcripts): 
    NM_001145166.1  NM_001145167.1  NM_005788.3  

    Unigene Cluster for PRMT3:

    Protein arginine methyltransferase 3
    Hs.152337  [show with all ESTs]
    Unigene Representative Sequence: AK125039
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331079(uc001mqb.3) ENST00000330796(uc001mqc.3 uc010rdn.2)
    ENST00000525188 ENST00000437750 ENST00000526583 ENST00000529592

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    hsa-miR-3163 hsa-miR-607 hsa-miR-548am hsa-miR-548x hsa-miR-648 hsa-miR-4282 hsa-miR-218
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF059531.1 AK125039.1 AK129984.1 AK298185.1 AK300591.1 AK301449.1 AK307776.1 BC019339.1 
    BC037544.1 BC047226.1 BC064831.1 

    7 DOTS entries:

    DT.95268561  DT.100778488  DT.99951853  DT.101982543  DT.92430010  DT.100778489  DT.100023631 

    24/97 AceView cDNA sequences (see all 97):

    BM459248 AA508769 CD107462 CA454164 BF513925 BF114844 BC037544 AL583012 
    AI383794 BM787108 BM788645 AW768682 AI016195 BX502395 BG499123 BQ774524 
    NM_005788 CA428457 BU599774 BU616880 AA307385 BX509356 BE779934 BG614029 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                      
    SP2:        -                                                                                             


    ECgene alternative splicing isoforms for PRMT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRMT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACTGTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PRMT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRMT3

    SOURCE GeneReport for Unigene cluster: Hs.152337
        SABiosciences Expression via Pathway-Focused PCR Array including PRMT3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT3 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PRMT31 protein arginine methyltransferase 3 73.92(n)
    72.75(a)
      422975  NM_001199471.1  NP_001186400.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT36
    --
    68(a)
    1 ↔ 1
    1(57037502-57110009)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC760342 hypothetical protein MGC76034 76.27(n)    BC061427.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prmt31 protein arginine methyltransferase 3 63.73(n)
    63(a)
      550348  NM_001017655.1  NP_001017655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art31 Arginine methyltransferase 3 47.92(n)
    41.33(a)
      41837  NM_142177.3  NP_650434.1 
    rice
    (Oryza sativa)
    Liliopsida Os.122672 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.73(n)    AK101865.1 


    ENSEMBL Gene Tree for PRMT3 (if available)
    TreeFam Gene Tree for PRMT3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRMT3 gene
    PRMT62  CARM12  PRMT22  PRMT12  PRMT82  
    5 SIMAP similar genes for PRMT3 using alignment to 4 protein entries:     ANM3_HUMAN (see all proteins):
    PRMT8    PRMT1    HRMT1L2    PRMT2    PRMT6

    PRMT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/75 NCBI SNPs in PRMT3 are shown (see all 75    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1179666201,2
    C,F,--20412753(+) CTTTCG/ATAAGG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs1830665351,2
    --20412768(+) AATGAC/TAGCCT 1 -- int10--------
    rs1890901931,2
    --20412894(+) TCAAGA/TGATTC 1 -- int10--------
    rs107666661,2
    C,A,H,--20412917(+) CTCCCG/AAGTAG 1 -- int12Minor allele frequency- A:0.00NA 4
    rs107666671,2
    C,F,A,H,--20412941(+) CATGCA/GCCACC 1 -- int17Minor allele frequency- G:0.14WA NA CSA 14
    rs113514681,2
    C,--20413462(+) GGATC-/TTAATT 1 -- int14Minor allele frequency- T:0.00NA CSA 8
    rs353579711,2
    C--20422519(+) TTGGA-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs802315361,2
    C,--20425707(+) TTTAG-/TTTTTT 3 -- int10--------
    rs108333201,2
    C,A--20425763(+) TTTTTG/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.17NA WA 6
    rs128085711,2
    C--20425764(+) TTTTTG/TTTTTt 1 -- int1 trp31Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for PRMT3 (20409076 - 20530879 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PRMT3
         1 CNV: 101152
         1 Indel: 41601
    Human Gene Mutation Database (HGMD): PRMT3

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PRMT3 for disorders           About GeneDecksing

    OMIM gene information: 603190    OMIM disorders: --

    3 diseases for PRMT3:    About MalaCards
    homocysteine    breast cancer    malaria

    Human Genome Epidemiology (HuGE) Navigator: PRMT3 (3 documents)

    Export disorders for PRMT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRMT3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with PRMT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. (PubMed id 9642256)1, 2, 3 Tang J.... Herschman H.R. (1998)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)1, 9 Choi S....Im D.S. (2008)
    5. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PubMed id 15334060)1, 9 Singh V....Newsham I.F. (2004)
    6. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. (PubMed id 16157300)1, 9 Miranda T.B.... Clarke S. (2005)
    7. PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits. (PubMed id 15175657)1, 9 Bachand F. and Silver P.A. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Protein arginine methyltransferase 1-directed methylat ion of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. (PubMed id 22179613)1 Campbell M....Izumiya Y. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10196 HGNC: 30163 AceView: HRMT1L3 Ensembl:ENSG00000185238 euGenes: HUgn10196
    ECgene: PRMT3 H-InvDB: PRMT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRMT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRMT3 gene:
    Search GeneIP for patents involving PRMT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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