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PRMT3 Gene

protein-coding   GIFtS: 62
GCID: GC11P020409

Protein Arginine Methyltransferase 3

(Previous name: HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae))
(Previous symbol: HRMT1L3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 31 2     HMT1 HnRNP Methyltransferase-Like 32
HRMT1L31 2 3     Protein Arginine N-Methyltransferase 32
Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 32 3     EC 2.1.1.-3
HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae)1     EC 2.1.18

External Ids:    HGNC: 301631   Entrez Gene: 101962   Ensembl: ENSG000001852387   OMIM: 6031905   UniProtKB: O606783   

Export aliases for PRMT3 gene to outside databases

Previous GC identifers: GC11M021595 GC11U900019 GC11P020448 GC11P020373 GC11P020092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRMT3 Gene:
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the
methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2
(rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for PRMT3 Gene:
PRMT3 (protein arginine methyltransferase 3) is a protein-coding gene. Diseases associated with PRMT3 include fragile x syndrome, and kaposi's sarcoma. GO annotations related to this gene include protein-arginine N-methyltransferase activity and protein-arginine omega-N asymmetric methyltransferase activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678
Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some
proteins

Gene Wiki entry for PRMT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT3 gene promoter:
         TBP   AML1a   POU6F1 (c2)   NF-E2 p45   HNF-1A   N-Myc   HNF-1   TFIID   LHX3a/Lhx3a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT3 promoter sequence
   Search Chromatin IP Primers for PRMT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

PRMT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P020409:  view genomic region     (about GC identifiers)

Start:
20,409,076 bp from pter      End:
20,530,879 bp from pter
Size:
121,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 3  
Size: 531 amino acids; 59876 Da
Subunit: Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target
proteins. Interacts with the 40S ribosomal protein RPS2
3 PDB 3D structures from and Proteopedia for PRMT3:
2FYT (3D)        3SMQ (3D)        4HSG (3D)    
Secondary accessions: B4DUC7
Alternative splicing: 2 isoforms:  O60678-1   O60678-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT3: NX_O60678

Explore proteomics data for PRMT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys187
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRMT3 (O60678) (see all 9)
     KVVLDVG  HEEMLKD  GIHEEML  VLDVGCG 


    See PRMT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138638.1  NP_001138639.1  NP_005779.1  

    ENSEMBL proteins: 
     ENSP00000331879   ENSP00000329586   ENSP00000435151   ENSP00000397766   ENSP00000434260  

    PRMT3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PRMT3

    PRMT3 Antibody Products:

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    PRMT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PRMT3
    Cloud-Clone Corp. CLIAs for PRMT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT3
    Protein arginine N-methyltransferases

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR025799 Arg_MeTrfase
     IPR010456 Ribosomal-L11_MeTrfase_PrmA
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O60678

    ProtoNet protein and cluster: O60678

    1 Blocks protein domain: IPB013216 Methyltransferase type 11

    UniProtKB/Swiss-Prot: ANM3_HUMAN, O60678
    Domain: The zinc-finger is responsible for substrate specificity (By similarity)
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain


    PRMT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM3_HUMAN, O60678
    Function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some
    proteins
    Enzyme regulation: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride (By similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18573314
    GO:0008168methyltransferase activity IDA18573314
    GO:0008276protein methyltransferase activity ----
    GO:0008469histone-arginine N-methyltransferase activity IBA--
    GO:0016274protein-arginine N-methyltransferase activity NAS9642256
         
    PRMT3 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prmt3):
     embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  skeleton  vision/eye 

    PRMT3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRMT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRMT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRMT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRMT3

    miRNA
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    miRTarBase miRNAs that target PRMT3:
    hsa-mir-1260b (MIRT052756), hsa-mir-361-3p (MIRT038276), hsa-mir-106b-5p (MIRT044363)

    Block miRNA regulation of human, mouse, rat PRMT3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PRMT3:
    hsa-miR-3163 hsa-miR-607 hsa-miR-548am hsa-miR-548x hsa-miR-648 hsa-miR-4282 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPRMT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRMT3
    Predesigned siRNA for gene silencing in human, mouse, rat PRMT3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRMT3 (NM_005788)
    Sino Biological Human cDNA Clone for PRMT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PRMT3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM3_HUMAN, O60678: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS9642256
    GO:0005829cytosol IBA--
    GO:0005840ribosome IEA--

    PRMT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRMT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRMT3 (O606781, 2, 3 ENSP000003318794) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCN5AQ145241, 2EBI-2809009,EBI-726858 MINT-8435152 MINT-8435118
    HNRNPKP619782, 3, ENSP000003654394MINT-6803896 I2D: score=1 STRING: ENSP00000365439
    FBLP220873, ENSP000002218014I2D: score=1 STRING: ENSP00000221801
    PABPN1Q86U423, ENSP000002167274I2D: score=1 STRING: ENSP00000216727
    RPS2P158803, ENSP000003418854I2D: score=1 STRING: ENSP00000341885
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006479protein methylation ----
    GO:0008150biological_process ----
    GO:0008152metabolic process ----
    GO:0018216peptidyl-arginine methylation ----

    PRMT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT3 (ANM3)

    Selected HMDB Compounds for PRMT3 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistidine1 methylhistidine (see all 9)332-80-91446680
    2-HydroxyestradiolEstra-1,3,5(10)-triene-2,3,17b-triol (see all 15)362-05-0--
    2-Methoxyestradiol2-Methoxyestradiol 362-07-2--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--
    ChlorineCl2 (see all 13)16887-00-6--
    Hordenine4-(2-Dimethylaminoethyl)phenol (see all 16)539-15-1--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    N-Methyltyramine{p-[2-(Methylamino)ethyl]phenol} (see all 12)370-98-9--
    Se-Adenosylselenohomocysteine ----

    1 DrugBank Compound for PRMT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235

    1 Novoseek inferred chemical compound relationship for PRMT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 66.8 19 15334060 (3), 15473865 (2), 16190779 (1), 10931850 (1) (see all 7)



    PRMT3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRMT3 gene (3 alternative transcripts): 
    NM_001145166.1  NM_001145167.1  NM_005788.3  

    Unigene Cluster for PRMT3:

    Protein arginine methyltransferase 3
    Hs.152337  [show with all ESTs]
    Unigene Representative Sequence: AK125039
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331079(uc001mqb.3) ENST00000330796(uc001mqc.3 uc010rdn.2)
    ENST00000525188 ENST00000437750 ENST00000526583 ENST00000529592
    miRNA
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    Block miRNA regulation of human, mouse, rat PRMT3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PRMT3:
    hsa-miR-3163 hsa-miR-607 hsa-miR-548am hsa-miR-548x hsa-miR-648 hsa-miR-4282 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidPRMT3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRMT3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRMT3 (NM_005788)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT3
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PRMT3
      QuantiFast Probe-based Assays in human, mouse, rat PRMT3

    Additional mRNA sequence: 

    AF059531.1 AK125039.1 AK129984.1 AK298185.1 AK300591.1 AK301449.1 AK307776.1 BC019339.1 
    BC037544.1 BC047226.1 BC064831.1 

    7 DOTS entries:

    DT.95268561  DT.100778488  DT.99951853  DT.101982543  DT.92430010  DT.100778489  DT.100023631 

    Selected AceView cDNA sequences (see all 97):

    AA508769 BM787108 BC037544 BM459248 BF114844 BF513925 BM788645 AI016195 
    AL583012 AI383794 AW768682 CA454164 CD107462 BI544798 BX509356 AI087787 
    BG770884 BF979089 BU623763 BX390979 BG030714 BQ774524 AA307385 BE779934 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                      
    SP2:        -                                                                                             


    ECgene alternative splicing isoforms for PRMT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRMT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTGTTAC
    PRMT3 Expression
    About this image

    PRMT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.152337
        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT3: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PRMT3
    OriGene qSTAR qPCR primer pairs in human, mouse for PRMT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRMT3
    QuantiTect SYBR Green Assays in human, mouse, rat PRMT3
    QuantiFast Probe-based Assays in human, mouse, rat PRMT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt31 , 5 protein arginine N-methyltransferase 31, 5 87.1(n)1
    90.7(a)1
      7 (31.44 cM)5
    719741  NM_133740.21  NP_598501.11 
     497783465 
    chicken
    (Gallus gallus)
    Aves PRMT31 protein arginine methyltransferase 3 73.78(n)
    72.6(a)
      422975  NM_001199471.1  NP_001186400.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT36
    protein arginine methyltransferase 3
    68(a)
    1 ↔ 1
    1(57036879-57112157)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC760342 hypothetical protein MGC76034 76.27(n)    BC061427.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prmt31 protein arginine methyltransferase 3 63.73(n)
    63(a)
      550348  NM_001017655.1  NP_001017655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art31 Arginine methyltransferase 3 47.89(n)
    41.63(a)
      41837  NM_142177.4  NP_650434.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT16
    Nuclear SAM-dependent mono- and asymmetric arginin...
    42(a)
    1 → many
    II(304930-305976) YBR034C
    rice
    (Oryza sativa)
    Liliopsida Os.122672 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.73(n)    AK101865.1 


    ENSEMBL Gene Tree for PRMT3 (if available)
    TreeFam Gene Tree for PRMT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT3 gene
    PRMT62  CARM12  PRMT22  PRMT12  PRMT82  
    5 SIMAP similar genes for PRMT3 using alignment to 4 protein entries:     ANM3_HUMAN (see all proteins):
    PRMT8    PRMT1    HRMT1L2    PRMT2    PRMT6

    PRMT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PRMT3 (see all 2324)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400658791,2
    --20090447(+) CAAAGA/GAAAAC 3 -- us2k10--------
    rs1497001721,2
    --20090472(+) ATATTC/TAATGG 3 -- us2k10--------
    rs108333161,2
    C,F,A--20090489(+) TCCTCC/TAGGAA 3 -- us2k112Minor allele frequency- T:0.32NA WA CSA EA 375
    rs786675021,2
    C,F--20090568(+) CAGTGA/GATACA 3 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1854394061,2
    --20090656(+) CTTACC/TCTTAT 3 -- us2k10--------
    rs2002720911,2
    --20090692(+) AAAAG-/AAAAAA 3 -- us2k10--------
    rs734429591,2
    C,F--20090760(+) TGGTGG/CAAACT 3 -- us2k12Minor allele frequency- C:0.10WA 120
    rs765397561,2
    F--20090786(+) TGAGGA/GAAGTG 3 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1159444141,2
    F--20090920(+) GGCCTG/AATAGG 3 -- us2k11Minor allele frequency- A:0.04WA 118
    rs110255381,2
    C,F,A--20091000(+) CTCGCC/GGGCAG 3 -- us2k111Minor allele frequency- G:0.32NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for PRMT3 (20409076 - 20530879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRMT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2616116CNV Deletion19546169
    esv2663802CNV Deletion23128226
    esv2744183CNV Deletion23290073
    esv2744184CNV Deletion23290073
    esv3723CNV Deletion18987735
    nsv467720CNV Gain19166990
    nsv832083CNV Gain17160897
    nsv469939CNV Gain18288195

    Human Gene Mutation Database (HGMD): PRMT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRMT3
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603190    OMIM disorders: --

    8 diseases for PRMT3:    
    About MalaCards
    fragile x syndrome    kaposi's sarcoma    coronary heart disease    sarcoma
    lymphoblastic leukemia    mental retardation    leukemia    breast cancer


    PRMT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRMT3
    Human Genome Epidemiology (HuGE) Navigator: PRMT3 (3 documents)

    Export disorders for PRMT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT3 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with PRMT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. (PubMed id 9642256)1, 2, 3 Tang J.... Herschman H.R. (J. Biol. Chem. 1998)
    2. DAL-1/4.1B tumor suppressor interacts with protein arginine N- methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PubMed id 15334060)1, 2, 9 Singh V.... Newsham I.F. (Oncogene 2004)
    3. Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3). (PubMed id 21059412)1, 2 Handrkova H....Cmejla R. (Biochim. Biophys. Acta 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PubMed id 18573314)1, 9 Choi S....Im D.S. (Biochim. Biophys. Acta 2008)
    8. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PubMed id 15473865)1, 9 Swiercz R....Bedford M.T. (Biochem. J. 2005)
    9. Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. (PubMed id 16190779)1, 9 Smith C.L....Vallance P. (PLoS Med. 2005)
    10. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PubMed id 16420693)1, 9 Jiang W. and Newsham I.F. (Mol. Cancer 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10196 HGNC: 30163 AceView: HRMT1L3 Ensembl:ENSG00000185238 euGenes: HUgn10196
    ECgene: PRMT3 H-InvDB: PRMT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRMT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRMT3 gene:
    Search GeneIP for patents involving PRMT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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