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Aliases for PRMT3 Gene

Aliases for PRMT3 Gene

  • Protein Arginine Methyltransferase 3 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 3 4
  • HRMT1L3 3 4
  • HMT1 HnRNP Methyltransferase-Like 3 (S. Cerevisiae) 2
  • HMT1 HnRNP Methyltransferase-Like 3 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for PRMT3 Gene

Previous HGNC Symbols for PRMT3 Gene

  • HRMT1L3

Previous GeneCards Identifiers for PRMT3 Gene

  • GC11M021595
  • GC11U900019
  • GC11P020448
  • GC11P020373
  • GC11P020092

Summaries for PRMT3 Gene

Entrez Gene Summary for PRMT3 Gene

  • This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRMT3 Gene

PRMT3 (Protein Arginine Methyltransferase 3) is a Protein Coding gene. Diseases associated with PRMT3 include myopathy of extraocular muscle. GO annotations related to this gene include methyltransferase activity and histone-arginine N-methyltransferase activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for PRMT3 Gene

  • Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Tocris Summary for PRMT3 Gene

Gene Wiki entry for PRMT3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT3 Gene

Genomics for PRMT3 Gene

Regulatory Elements for PRMT3 Gene

Enhancers for PRMT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRMT3 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRMT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRMT3 Gene

Chromosome:
11
Start:
20,387,530 bp from pter
End:
20,509,333 bp from pter
Size:
121,804 bases
Orientation:
Plus strand

Genomic View for PRMT3 Gene

Genes around PRMT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT3 Gene

Proteins for PRMT3 Gene

  • Protein details for PRMT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60678-ANM3_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 3
    Protein Accession:
    O60678
    Secondary Accessions:
    • B4DUC7

    Protein attributes for PRMT3 Gene

    Size:
    531 amino acids
    Molecular mass:
    59876 Da
    Quaternary structure:
    • Monomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2.

    Three dimensional structures from OCA and Proteopedia for PRMT3 Gene

    Alternative splice isoforms for PRMT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT3 Gene

Proteomics data for PRMT3 Gene at MOPED

Selected DME Specific Peptides for PRMT3 Gene

Post-translational modifications for PRMT3 Gene

  • Ubiquitination at Lys 187
  • Modification sites at PhosphoSitePlus

Other Protein References for PRMT3 Gene

Antibody Products

Domains & Families for PRMT3 Gene

Gene Families for PRMT3 Gene

Protein Domains for PRMT3 Gene

Suggested Antigen Peptide Sequences for PRMT3 Gene

Graphical View of Domain Structure for InterPro Entry

O60678

UniProtKB/Swiss-Prot:

ANM3_HUMAN :
  • The zinc-finger is responsible for substrate specificity.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • The zinc-finger is responsible for substrate specificity.
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with PRMT3: view

Function for PRMT3 Gene

Molecular function for PRMT3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide and high concentrations of zinc chloride.
UniProtKB/Swiss-Prot Function:
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Enzyme Numbers (IUBMB) for PRMT3 Gene

Gene Ontology (GO) - Molecular Function for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA,IDA 18573314
GO:0008469 histone-arginine N-methyltransferase activity IBA --
GO:0016274 protein-arginine N-methyltransferase activity IEA,NAS 9642256
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IBA --
genes like me logo Genes that share ontologies with PRMT3: view
genes like me logo Genes that share phenotypes with PRMT3: view

Animal Models for PRMT3 Gene

MGI Knock Outs for PRMT3:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT3 Gene

Localization for PRMT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT3 Gene COMPARTMENTS Subcellular localization image for PRMT3 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9642256
GO:0005829 cytosol IEA,IBA --
genes like me logo Genes that share ontologies with PRMT3: view

Pathways & Interactions for PRMT3 Gene

SuperPathways for PRMT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRMT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA --
GO:0031397 negative regulation of protein ubiquitination IDA 18573314
GO:0034969 histone arginine methylation IBA --
genes like me logo Genes that share ontologies with PRMT3: view

No data available for Pathways by source and SIGNOR curated interactions for PRMT3 Gene

Drugs & Compounds for PRMT3 Gene

(6) Drugs for PRMT3 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma Target 0
2-Methoxyestradiol Investigational Pharma 9
COMPOUND 1 [PMID: 22795084] Pharma 0
Serotonin Pharma 3472

(8) Additional Compounds for PRMT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-hydroxyestradiol
  • (17b)-Estra-1,3, 5(10)-triene-2,3,17-triol
  • (17beta)- Estra-1,3, 5 (10)-triene-2,3,17-triol
  • (17beta)-Estra-1,3,5(10)-triene-2,3,17-triol
  • 1,3,5(10)-Estratriene-2,3,17Beta-triol
  • 17beta-2-Hydroxyestradiol
362-05-0
5-Hydroxyindoleacetaldehyde
  • (5-hydroxy-1H-indol-3-yl)acetaldehyde
  • (5-hydroxyindol-3-yl)acetaldehyde
  • 5-Hial
  • 5-Hydroxy-1H-Indole-3-acetaldehyde
  • 5-Hydroxyindole-3-acetaldehyde
1892-21-3
5-Methoxytryptamine
  • 2-(5-Methoxy-1H-indol-3-yl)ethanamine
  • 2-(5-Methoxyindol-3-yl)ethylamine
  • 3-(2-Aminoethyl)-5-methoxyindole
  • 5-Mot
  • 5MOT
608-07-1
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Hordenine
  • 4-(2-Dimethylaminoethyl)phenol
  • 4-[2-(Dimethylamino)ethyl]phenol
  • Anhalin
  • Anhaline
  • Cactine
539-15-1
genes like me logo Genes that share compounds with PRMT3: view

Transcripts for PRMT3 Gene

Unigene Clusters for PRMT3 Gene

Protein arginine methyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2: -

Relevant External Links for PRMT3 Gene

GeneLoc Exon Structure for
PRMT3
ECgene alternative splicing isoforms for
PRMT3

Expression for PRMT3 Gene

mRNA expression in normal human tissues for PRMT3 Gene

Protein differential expression in normal tissues from HIPED for PRMT3 Gene

This gene is overexpressed in Breast (51.6) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRMT3 Gene



SOURCE GeneReport for Unigene cluster for PRMT3 Gene Hs.152337

genes like me logo Genes that share expression patterns with PRMT3: view

Protein tissue co-expression partners for PRMT3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRMT3 Gene

Orthologs for PRMT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT3 35
  • 91.9 (n)
  • 91.65 (a)
PRMT3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT3 35
  • 92.4 (n)
  • 92.09 (a)
PRMT3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt3 35
  • 87.1 (n)
  • 90.7 (a)
Prmt3 16
Prmt3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRMT3 35
  • 99.56 (n)
  • 99.62 (a)
PRMT3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prmt3 35
  • 86.46 (n)
  • 89.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PRMT3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRMT3 35
  • 73.78 (n)
  • 72.6 (a)
PRMT3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRMT3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76034 35
prmt3 35
  • 66.6 (n)
  • 65.35 (a)
zebrafish
(Danio rerio)
Actinopterygii prmt3 35
  • 63.73 (n)
  • 63 (a)
prmt3 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003593 35
  • 51.59 (n)
  • 47.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Art3 35
  • 47.89 (n)
  • 41.63 (a)
Art3 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 36
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12267 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11923 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01669 35
  • 45.5 (n)
  • 38.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt3 35
  • 49.25 (n)
  • 40.94 (a)
Species with no ortholog for PRMT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRMT3 Gene

ENSEMBL:
Gene Tree for PRMT3 (if available)
TreeFam:
Gene Tree for PRMT3 (if available)

Paralogs for PRMT3 Gene

Paralogs for PRMT3 Gene

(5) SIMAP similar genes for PRMT3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRMT3: view

Variants for PRMT3 Gene

Sequence variations from dbSNP and Humsavar for PRMT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3758805 - 20,464,517(+) TTACC(C/G)TGAAA reference, missense
rs6483700 - 20,508,340(+) CAAGA(A/G)TAAGA reference, missense
rs11025585 - 20,494,177(+) GTTCT(C/G/T)TACGG reference, missense
rs736283 -- 20,489,318(-) AGGGG(A/G)AAAAA intron-variant
rs737183 -- 20,486,649(+) CATTG(G/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT3 Gene

Variant ID Type Subtype PubMed ID
nsv469939 CNV Gain 18288195
nsv467720 CNV Gain 19166990
nsv832083 CNV Gain 17160897
esv2616116 CNV Deletion 19546169
esv2744183 CNV Deletion 23290073
esv3723 CNV Deletion 18987735
esv2663802 CNV Deletion 23128226
esv2744184 CNV Deletion 23290073

Variation tolerance for PRMT3 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT3 Gene

HapMap Linkage Disequilibrium report
PRMT3
Human Gene Mutation Database (HGMD)
PRMT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT3 Gene

Disorders for PRMT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy of extraocular muscle
  • myopathy of extraocular muscles
- elite association - COSMIC cancer census association via MalaCards
Search PRMT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRMT3

Genetic Association Database (GAD)
PRMT3
Human Genome Epidemiology (HuGE) Navigator
PRMT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT3
genes like me logo Genes that share disorders with PRMT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT3 Gene

Publications for PRMT3 Gene

  1. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. (PMID: 9642256) Tang J. … Herschman H.R. (J. Biol. Chem. 1998) 2 3 4 67
  2. PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex. (PMID: 18573314) Choi S. … Im D.S. (Biochim. Biophys. Acta 2008) 3 23
  3. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PMID: 16420693) Jiang W. … Newsham I.F. (Mol. Cancer 2006) 3 23
  4. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). (PMID: 15473865) Swiercz R. … Bedford M.T. (Biochem. J. 2005) 3 23
  5. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. (PMID: 16157300) Miranda T.B. … Clarke S. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for PRMT3 Gene

Sources for PRMT3 Gene

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