PRMT2 Gene
protein-coding GIFtS: 57
GCID: GC21P048055
|
|
protein arginine methyltransferase 2(Previous names: HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1, HMT1...)
(Previous symbol: HRMT1L1)
| |
Aliases
for PRMT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Arginine Methyltransferase 21 2 | | PRMT2 Alpha2 | | HRMT1L11 2 3 5 | | PRMT2 Beta2 | | HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 11 2 | | PRMT2 Gamma2 | | Histone-Arginine N-Methyltransferase PRMT22 3 | | Protein Arginine N-Methyltransferase 22 | | MGC1113731 | | EC 2.1.1.-3 | | HMT1 HnRNP Methyltransferase-Like 1 (S. Cerevisiae)1 | | EC 2.1.1.1253 | | HMT1 HnRNP Methyltransferase-Like 12 | | HMT13 |
Export aliases for PRMT2 gene to outside databasesPrevious GC identifers: GC21P046880 GC21P033435 |
Summaries
for PRMT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such asSTAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation.Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG,RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation
Gene Wiki entry for PRMT2
|
Genomic Views
for PRMT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011515.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRMT2 gene promoter:
STAT1 AP-1 AP-2alpha isoform 3 ATF-2 AP-2alpha isoform 2 AP-2alpha isoform 4 c-Jun NF-kappaB1 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRMT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3PRMT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P048055: view genomic region
(about GC identifiers)
Start:
|
48,055,079 bp from pter |
End:
|
48,085,036 bp from pter |
Size:
|
29,958 bases |
Orientation:
|
plus strand |
|
Proteins
for PRMT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345 (See
protein sequence)Recommended Name: Protein arginine N-methyltransferase 2 Size: 433 amino acids; 49042 Da
Subunit: Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (viaSH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRAand THRB. Interacts with HNRNPUL1
Subcellular location: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure
1 PDB 3D structure from  and Proteopedia  for PRMT2:1X2P (3D)
Secondary accessions: P78350 Q498Y5 Q6FHF0 Q99781 Q9BW15 Q9UMC2Alternative splicing: 3 isoforms: P55345-1 P55345-2 P55345-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PRMT2: NX_P55345
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55345
PRMT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001229793.1 NP_001229794.1 NP_001229795.1 NP_001526.2 NP_996845.1
ENSEMBL proteins: ENSP00000347906 ENSP00000380760 ENSP00000380759 ENSP00000335490 ENSP00000380752 ENSP00000397266 ENSP00000406127 ENSP00000407463 ENSP00000411984 ENSP00000291705
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PRMT2 for ontologies About GeneDecksing
PRMT2 Antibody Products:
Assay Products for PRMT2: |
Protein
Domains /
Families
for PRMT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRMT2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55345ProtoNet protein and cluster: P55345 1 Blocks protein family: IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345Similarity: Belongs to the protein arginine N-methyltransferase familySimilarity: Contains 1 SH3 domain |
Function
for PRMT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such asSTAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation.Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG,RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1transcriptional activity (in a RB1-dependent manner). May be involved in growth regulationCatalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +N(omega)-methyl-arginine-[histone]Biophysicochemical properties: Kinetic parameters: KM=2.6 uM for AdoMet; KM=3.3 uM for H4; Vmax=1.4 nmol/min/mg enzymetoward AdoMet; Vmax=1.5 nmol/min/mg enzyme toward H4;Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.1.1251
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PRMT2 (NM_001535) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRMT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT2 |
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
PRMT2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRMT2:
Animal Models:
Mouse knock-out Prmt2tm1Enbl for PRMT2
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Prmt2):
PRMT2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRMT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
1  BioSystems Pathway for PRMT2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRMT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/24 Interacting proteins for PRMT2 (P553451, 2, 3 ENSP000003479064) via UniProtKB, MINT, STRING, and/or I2D (see all 24)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PRRC2A | P486342, 3, ENSP000003651754 | MINT-62625 MINT-62799 MINT-62723 I2D:
score=5 STRING: ENSP00000365175 | | AKR1B1 | P151212, 3, ENSP000002859304 | MINT-8290942 MINT-8291016 I2D:
score=1 STRING: ENSP00000285930 | | ESR1 | P033721, 2, 3, ENSP000002062494 | EBI-78458,EBI-78473 MINT-8290999 MINT-8290926 MINT-8290984 MINT-8291028 I2D:
score=5 STRING: ENSP00000206249 | | RB1 | P064001, 3, ENSP000002671634 | EBI-78458,EBI-491274 I2D:
score=4 STRING: ENSP00000267163 | | HNRNPK | P619782, 3, ENSP000003654394 | MINT-6803939 I2D:
score=1 STRING: ENSP00000365439 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
PRMT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRMT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRMT2
Search CenterWatch for drugs/clinical trials and news about PRMT2 / ANM2
|
Transcripts
for PRMT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRMT2 gene (5 alternative transcripts): NM_001242864.1 NM_001242865.1 NM_001242866.1 NM_001535.3 NM_206962.2 Unigene Cluster for PRMT2: Protein arginine methyltransferase 2 Hs.154163 [show with all ESTs]Unigene Representative Sequence: NM_00124286515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355680(uc002zjx.3 uc002zjy.3 uc011agb.2) ENST00000397638
ENST00000397637 ENST00000334494(uc021wkc.1) ENST00000397628 ENST00000440086(uc010gqm.3 uc011aga.2 uc011agc.2)
ENST00000482508(uc002zjz.1) ENST00000481861(uc002zjw.3) ENST00000455177
ENST00000491389 ENST00000498151 ENST00000486520 ENST00000458387 ENST00000451211
ENST00000291705
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PRMT2 (NM_001535) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRMT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT2 |
Additional cDNA sequence: AF059319.1 AK055950.1 AK095641.1 AK123650.1 AK124494.1 AK223157.1 AK312573.1 AL109794.1 AL833586.1 AY786414.2 BC000727.2 BC038765.1 BC100026.1 CR541804.1 FJ436410.1 FJ436411.1 FJ436412.1 U79286.1 U80213.1 X99209.1 24/25 DOTS entries (see all 25): DT.100821853 DT.448865 DT.100821850 DT.100714254 DT.100821849 DT.116524 DT.101985213 DT.91980706 DT.91880534 DT.444221 DT.91953079 DT.95151287 DT.121129834 DT.100821852 DT.91715558 DT.121129805 DT.95170216 DT.97860283 DT.40295406 DT.100692841 DT.100821851 DT.121129780 DT.121129796 DT.97793418 24/674 AceView cDNA sequences (see all 674): AI250921 BE152728 BU185873 AI694230 BQ007776 R07626 AW664265 CR601878 AA909503 BQ421001 AA279777 NM_001535 BM719452 AI126899 AW207159 BM682457 BM998720 AI095616 AA495821 BF445186 CB529922 AA705927 BX098798 AI051752
GeneLoc Exon Structure
5/24 Alternative Splicing Database (ASD) splice patterns (SP) for PRMT2 (see all 24) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 8d | · | 8e | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d |
|---|
|
| SP1: | - | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | - | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRMT2
|
Expression
for PRMT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRMT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAATAAAT
About this image
See PRMT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRMT2
SOURCE GeneReport for Unigene cluster: Hs.154163
UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345Tissue specificity: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletalmuscle, ovary and spinal cord
SABiosciences Expression via Pathway-Focused PCR Array including PRMT2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRMT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRMT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRMT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT2 |
Orthologs
for PRMT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRMT2 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
1377162692 |
-- |
70.97(n) |
|
137716269 |
zebrafish
(Danio rerio) |
Actinopterygii |
prmt21 |
protein arginine methyltransferase 2 |
59.85(n)
56.06(a) |
|
558841 NM_001080175.1 NP_001073644.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Art86 |
Arginine methyltransferase 8 |
33(a) |
1 ↔ 1 |
2L(11009821-11011085) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PRMT106 |
putative protein arginine N-methyltransferase 4.2 |
29(a) |
1 ↔ 1 |
1(1373234-1375762) |
rice
(Oryza sativa) |
Liliopsida |
-- |
methyltransferase domain containing protein, expre... |
30(a) |
1 ↔ 1 |
6(2246853-2249861) |
ENSEMBL Gene Tree for PRMT2 (if available)
TreeFam Gene Tree for PRMT2 (if available) |
Paralogs
for PRMT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRMT2 gene
- PRMT62 PRMT32 CARM12 PRMT12 PRMT82
6 SIMAP similar genes for PRMT2 using alignment to 9 protein entries: ANM2_HUMAN (see all proteins):PRMT1 CARM1 PRMT8 HRMT1L2 PRMT3 PRMT6
PRMT2 for paralogs About GeneDecksing
|
Genomic Variants
for PRMT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRMT2 (48055079 - 48085036 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PRMT2
4 CNVs: 8897 3235 31065 31064 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRMT2 |
|
Disorders
/ Diseases
for PRMT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRMT2 for disorders About GeneDecksing
OMIM gene information: 601961
OMIM disorders: --
8  diseases for PRMT2: About MalaCardsspina bifida homocysteine breast cancer thyroiditis
malaria prostatitis breast carcinoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: PRMT2 (1 document)
Export disorders for PRMT2 gene to outside databases
|
Publications
for PRMT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRMT2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with PRMT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PubMed id 9545638)1, 2, 3, 9 Scott H.S....Henry M.F. (1998)
- Kinetic analysis of human protein arginine N-methyltr ansferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PubMed id 19405910)1, 2, 9 Lakowski T.M. and Frankel A. (2009)
- Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. (PubMed id 9196002)1, 2, 9 Katsanis N.... Fisher E.M.C. (1997)
- PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. (PubMed id 17587566)1, 2 Meyer R....Obendorf M. (2007)
- Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. (PubMed id 16648481)1, 2 Ganesh L....Nabel G.J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. (PubMed id 12039952)1, 2 Qi C.... Zhu Y.-J. (2002)
- Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. (PubMed id 11513728)1, 2 Kzhyshkowska J....Dobner T. (2001)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
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External Searches for PRMT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PRMT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PRMT2 gene
(According to HUGE)
About This Section
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Specialized Databases showing PRMT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PRMT2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PRMT2 gene:
Search GeneIP for patents involving PRMT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PRMT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PRMT2 | | OriGene shRNA RFP for PRMT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRMT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRMT2 | | | OriGene Protein Over-expression Lysate for PRMT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for PRMT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRMT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRMT2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRMT2 | | OriGene Custom Protein Services for PRMT2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRMT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRMT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRMT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRMT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRMT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRMT2 |
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| | | | Search Tocris compounds for PRMT2 |
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 | | | PRMT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT2 |
|  |  |  | | | | ThermoFisher Antibodies for PRMT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT2 |
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