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PRMT2 Gene

protein-coding   GIFtS: 60
GCID: GC21P048055

Protein Arginine Methyltransferase 2

(Previous names: HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1, HMT1...)
(Previous symbol: HRMT1L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 21 2     PRMT2 Beta2
HRMT1L11 2 3 5     PRMT2 Gamma2
HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 11 2     Protein Arginine N-Methyltransferase 22
Histone-Arginine N-Methyltransferase PRMT22 3     EC 2.1.1.-3
HMT1 HnRNP Methyltransferase-Like 1 (S. Cerevisiae)1     EC 2.1.1.1253
HMT1 HnRNP Methyltransferase-Like 12     HMT13
PRMT2 Alpha2     

External Ids:    HGNC: 51861   Entrez Gene: 32752   Ensembl: ENSG000001603107   OMIM: 6019615   UniProtKB: P553453   

Export aliases for PRMT2 gene to outside databases

Previous GC identifers: GC21P046880 GC21P033435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRMT2 Gene:
PRMT2 (protein arginine methyltransferase 2) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and protein homodimerization activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345
Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such
as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated
transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation.
Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis.
Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation

Gene Wiki entry for PRMT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT2 gene promoter:
         STAT1   AP-1   AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 2   AP-2alpha isoform 4   c-Jun   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT2 promoter sequence
   Search Chromatin IP Primers for PRMT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

PRMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P048055:  view genomic region     (about GC identifiers)

Start:
48,055,079 bp from pter      End:
48,085,155 bp from pter
Size:
30,077 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 2  
Size: 433 amino acids; 49042 Da
Subunit: Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts
(via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG,
RARA, RXRA and THRB. Interacts with HNRNPUL1
1 PDB 3D structure from and Proteopedia for PRMT2:
1X2P (3D)    
Secondary accessions: P78350 Q498Y5 Q6FHF0 Q99781 Q9BW15 Q9UMC2
Alternative splicing: 3 isoforms:  P55345-1   P55345-2   P55345-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRMT2: NX_P55345

Explore proteomics data for PRMT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys124
  • Modification sites at PhosphoSitePlus

  • See PRMT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001229793.1  NP_001229794.1  NP_001229795.1  NP_001273605.1  NP_001273606.1  NP_001273607.1  NP_001526.2  NP_996845.1  

    ENSEMBL proteins: 
     ENSP00000347906   ENSP00000380760   ENSP00000380759   ENSP00000335490   ENSP00000380752  
     ENSP00000397266   ENSP00000406127   ENSP00000407463   ENSP00000411984   ENSP00000291705  

    PRMT2 Human Recombinant Protein Products:

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    Novus Biologicals PRMT2 Protein
    Novus Biologicals PRMT2 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRMT2

     
    Search eBioscience for Proteins for PRMT2 

     
    antibodies-online proteins for PRMT2 (6 products) 

     
    antibodies-online peptides for PRMT2

    PRMT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRMT2
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    antibodies-online antibodies for PRMT2 (62 products) 

    PRMT2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRMT2
    Cloud-Clone Corp. CLIAs for PRMT2
    Search eBioscience for ELISAs for PRMT2 
    antibodies-online kits for PRMT2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT2
    Protein arginine N-methyltransferases

    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR025799 Arg_MeTrfase

    Graphical View of Domain Structure for InterPro Entry P55345

    ProtoNet protein and cluster: P55345

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with PRMT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM2_HUMAN, P55345
    Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such
    as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated
    transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation.
    Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis.
    Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Biophysicochemical properties: Kinetic parameters: KM=2.6 uM for AdoMet; KM=3.3 uM for H4; Vmax=1.4 nmol/min/mg
    enzyme toward AdoMet; Vmax=1.5 nmol/min/mg enzyme toward H4;

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.1.1251

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA12039952
    GO:0004871signal transducer activity TAS9545638
    GO:0005515protein binding IPI11513728
    GO:0008168methyltransferase activity ----
    GO:0008276protein methyltransferase activity ----
         
    Find genes that share ontologies with PRMT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRMT2:
     Increased gamma-H2AX phosphory  Increased viability after born 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prmt2):
     cardiovascular system  cellular  homeostasis/metabolism  immune system  integument 
     no phenotypic analysis 

    Find genes that share phenotypes with PRMT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prmt2tm1Enbl for PRMT2

       genOway: Develop your customized and physiologically relevant rodent model for PRMT2

    miRNA
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    miRTarBase miRNAs that target PRMT2:
    hsa-mir-17-3p (MIRT050766)

    Block miRNA regulation of human, mouse, rat PRMT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRMT2 (see all 13):
    hsa-miR-3678-3p hsa-miR-875-3p hsa-miR-24-1* hsa-miR-513a-5p hsa-miR-1285 hsa-miR-7 hsa-miR-24-2* hsa-miR-138-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRMT2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT2 (NM_001535)
    Sino Biological Human cDNA Clone for PRMT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT2
    Addgene plasmids for PRMT2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM2_HUMAN, P55345: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone
    exposure
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11513728
    GO:0005737cytoplasm IDA11513728
    GO:0005829cytosol IDA17587566
    GO:0035189colocalizes with Rb-E2F complex ISS--

    Find genes that share ontologies with PRMT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRMT2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2RB in Cancer
    RB in Cancer


    2 BioSystems Pathways for PRMT2
        mRNA processing
    RB in Cancer



        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRMT2 (P553451, 2, 3 ENSP000003479064) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62625 MINT-62799 MINT-62723 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62625 MINT-62799 MINT-62723 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62625 MINT-62799 MINT-62723 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62625 MINT-62799 MINT-62723 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62625 MINT-62799 MINT-62723 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006479protein methylation TAS9545638
    GO:0007165signal transduction TAS9545638
    GO:0016571histone methylation ISS--
    GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA16648481

    Find genes that share ontologies with PRMT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT2 (ANM2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRMT2 gene (8 alternative transcripts): 
    NM_001242864.2  NM_001242865.2  NM_001242866.2  NM_001286676.1  NM_001286677.1  NM_001286678.1  NM_001535.4  NM_206962.3  

    Unigene Cluster for PRMT2:

    Protein arginine methyltransferase 2
    Hs.154163  [show with all ESTs]
    Unigene Representative Sequence: NM_001242865
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355680(uc002zjx.3 uc002zjy.3 uc011agb.2) ENST00000397638
    ENST00000397637 ENST00000334494(uc021wkc.1) ENST00000397628 ENST00000440086(uc010gqm.3 uc011aga.2 uc011agc.2)
    ENST00000482508(uc002zjz.1) ENST00000481861(uc002zjw.3) ENST00000455177
    ENST00000491389 ENST00000498151 ENST00000486520 ENST00000458387 ENST00000451211
    ENST00000291705
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    Selected qRT-PCR Assays for microRNAs that regulate PRMT2 (see all 13):
    hsa-miR-3678-3p hsa-miR-875-3p hsa-miR-24-1* hsa-miR-513a-5p hsa-miR-1285 hsa-miR-7 hsa-miR-24-2* hsa-miR-138-1*
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    Addgene plasmids for PRMT2 
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      QuantiFast Probe-based Assays in human, mouse, rat PRMT2

    Additional mRNA sequence: 

    AF059319.1 AK055950.1 AK095641.1 AK123650.1 AK124494.1 AK223157.1 AK312573.1 AL109794.1 
    AL833586.1 AY786414.2 BC000727.2 BC038765.1 BC100026.1 CR541804.1 FJ436410.1 FJ436411.1 
    FJ436412.1 U79286.1 U80213.1 X99209.1 

    Selected DOTS entries (see all 26):

    DT.100821853  DT.448865  DT.100821850  DT.100714254  DT.100821849  DT.116524  DT.101985213  DT.91980706 
    DT.91880534  DT.444221  DT.91953079  DT.95151287  DT.121129834  DT.100821852  DT.91715558  DT.107528 
    DT.121129805  DT.95170216  DT.97860283  DT.121129780  DT.40295406  DT.100692841  DT.100821851  DT.121129796 

    Selected AceView cDNA sequences (see all 674):

    CR541804 BM832334 AI694230 BM561913 BU162319 NM_001535 AW664265 BQ007776 
    AI051752 BM719452 BE502054 H45497 AA279777 BU839385 BE152728 CR601878 
    AA705927 AA666085 AI652459 AI460043 AI206981 AI656878 BQ015783 AL109794 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRMT2 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ·
    SP1:                                            -                             -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:                                            -     -     -                 -                                                                                 
    SP4:                                            -     -     -                 -                                                                                 
    SP5:                                            -     -     -                 -                                                                                 

    ExUns: 8d · 8e ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
    SP1:  -     -     -     -                 -           -                                             
    SP2:  -     -     -     -                 -           -                                             
    SP3:  -     -     -     -                 -           -                                             
    SP4:  -     -     -     -     -     -     -     -     -                                             
    SP5:  -     -                                                                                       


    ECgene alternative splicing isoforms for PRMT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAATAAAT
    PRMT2 Expression
    About this image


    PRMT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Kidney (Urinary System)
             Metanephros
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    PRMT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154163

    UniProtKB/Swiss-Prot: ANM2_HUMAN, P55345
    Tissue specificity: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal
    muscle, ovary and spinal cord

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRMT2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt21 , 5 protein arginine N-methyltransferase 21, 5 83.76(n)1
    88.22(a)1
      10 (38.74 cM)5
    154681  NM_133182.21  NP_573445.21 
     762072275 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377162692   -- 70.97(n)    137716269 
    zebrafish
    (Danio rerio)
    Actinopterygii prmt21 protein arginine methyltransferase 2 59.63(n)
    55.78(a)
      558841  NM_001080175.1  NP_001073644.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art86
    Arginine methyltransferase 8
    33(a)
    1 ↔ 1
    2L(11009821-11011085)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT16
    Nuclear SAM-dependent mono- and asymmetric arginin...
    33(a)
    1 → many
    II(304930-305976) YBR034C


    ENSEMBL Gene Tree for PRMT2 (if available)
    TreeFam Gene Tree for PRMT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT2 gene
    PRMT62  PRMT32  CARM12  PRMT12  PRMT82  
    6 SIMAP similar genes for PRMT2 using alignment to 9 protein entries:     ANM2_HUMAN (see all proteins):
    PRMT1    CARM1    PRMT8    HRMT1L2    PRMT3    PRMT6

    Find genes that share paralogs with PRMT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRMT2 (see all 815)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611103071,2
    C--33445104(+) AAAAA-/AA/TAGGAAAAATTCTATAAATCTATGAATGATACTACGTGAGCCATGATGG
    TGCTGTTGCACTTCAGCCTGGGCTACAGAGCGAGAGCCTGTCTCAAAAAAAAAAA
    TAGAA
    5 -- int11NA 2
    rs602834411,2
    C--48053599(+) TTTTT-/TCTTTT 5 -- us2k10--------
    rs99798621,2
    C--48053648(+) ccacaT/Ccacct 5 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1459054951,2
    C--48053656(+) CCTTT-/TGTGTGT 5 -- us2k10--------
    rs568223801,2
    C--48053670(+) GTGTG-/T/TG  
            
    GTGGG
    5 -- us2k10--------
    rs1123495151,2
    F--48053700(+) CACTTC/TAGAGG 5 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs99774921,2
    C,F--48053710(+) gcctcA/Gcttct 5 -- us2k19Minor allele frequency- G:0.45NA WA CSA EA 370
    rs1435976471,2
    C--48053742(+) GGTTTC/TGATCA 5 -- us2k10--------
    rs1878641441,2
    --48053795(+) GAACAA/GAAAAC 5 -- us2k10--------
    rs1931555071,2
    --48053820(+) AAAAAA/CCAGTT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRMT2 (48055079 - 48085155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PRMT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658047CNV Deletion23128226
    esv1540677CNV Insertion17803354
    nsv9864CNV Gain18304495
    esv34393CNV Gain17911159
    nsv470910CNV Gain18288195
    nsv9865CNV Gain18304495
    dgv1375e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601961    OMIM disorders: --


    Find genes that share disorders with PRMT2           About GenesLikeMe

    Genetic Association Database (GAD): PRMT2
    Human Genome Epidemiology (HuGE) Navigator: PRMT2 (1 document)

    Export disorders for PRMT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PRMT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PubMed id 9545638)1, 2, 3, 9 Scott H.S....Henry M.F. (Genomics 1998)
    2. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PubMed id 19405910)1, 2, 9 Lakowski T.M. and Frankel A. (Biochem. J. 2009)
    3. Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. (PubMed id 9196002)1, 2, 9 Katsanis N.... Fisher E.M.C. (Mamm. Genome 1997)
    4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    5. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. (PubMed id 17587566)1, 2 Meyer R.... Obendorf M. (J. Steroid Biochem. Mol. Biol. 2007)
    6. Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. (PubMed id 16648481)1, 2 Ganesh L.... Nabel G.J. (Mol. Cell. Biol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. (PubMed id 12039952)1, 2 Qi C.... Zhu Y.-J. (J. Biol. Chem. 2002)
    10. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. (PubMed id 11513728)1, 2 Kzhyshkowska J....Dobner T. (Biochem. J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3275 HGNC: 5186 AceView: HRMT1L1 Ensembl:ENSG00000160310 euGenes: HUgn3275
    ECgene: PRMT2 H-InvDB: PRMT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRMT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRMT2 gene:
    Search GeneIP for patents involving PRMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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