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Aliases for PRMT2 Gene

Aliases for PRMT2 Gene

  • Protein Arginine Methyltransferase 2 2 3 5
  • HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 1 2 3
  • Histone-Arginine N-Methyltransferase PRMT2 3 4
  • HRMT1L1 3 4
  • HMT1 HnRNP Methyltransferase-Like 1 (S. Cerevisiae) 2
  • Protein Arginine N-Methyltransferase 2 3
  • HMT1 HnRNP Methyltransferase-Like 1 3
  • EC 2.1.1.319 4
  • PRMT2 Alpha 3
  • PRMT2 Gamma 3
  • PRMT2 Beta 3
  • HMT1 4

External Ids for PRMT2 Gene

Previous HGNC Symbols for PRMT2 Gene

  • HRMT1L1

Previous GeneCards Identifiers for PRMT2 Gene

  • GC21P046880
  • GC21P048055
  • GC21P033435

Summaries for PRMT2 Gene

GeneCards Summary for PRMT2 Gene

PRMT2 (Protein Arginine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are RB in Cancer and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein homodimerization activity and transcription coactivator activity. An important paralog of this gene is PRMT3.

UniProtKB/Swiss-Prot for PRMT2 Gene

  • Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.

Tocris Summary for PRMT2 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT2 Gene

Genomics for PRMT2 Gene

Regulatory Elements for PRMT2 Gene

Enhancers for PRMT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F046660 1.3 Ensembl ENCODE 16.5 +26.6 26622 1.8 CTCF MAZ SIN3A MNT REST RAD21 E2F1 EGR1 SMC3 ZNF143 S100B PRMT2 DSTNP1 RPL23AP4
GH21F046573 0.3 FANTOM5 13.3 -61.3 -61341 0.3 S100B PRMT2 DIP2A RNU6-396P
GH21F046550 0.7 Ensembl ENCODE 12.6 -83.2 -83214 3.9 CTCF KLF9 S100B PRMT2 SPATC1L RNU6-396P
GH21F046632 0.4 ENCODE 11.4 +0.1 63 4.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 S100B ENSG00000228137 MCM3AP MCM3AP-AS1 ENSG00000227438 ENSG00000228235 LOC105372842 DSTNP1 PRMT2 SPATC1L
GH21F046649 1 ENCODE 11 +15.4 15373 1.7 ZFHX2 PRMT2 S100B DSTNP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRMT2 on UCSC Golden Path with GeneCards custom track

Promoters for PRMT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107333 1447 3601 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for PRMT2 Gene

Chromosome:
21
Start:
46,635,153 bp from pter
End:
46,665,685 bp from pter
Size:
30,533 bases
Orientation:
Plus strand

Genomic View for PRMT2 Gene

Genes around PRMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT2 Gene

Proteins for PRMT2 Gene

  • Protein details for PRMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55345-ANM2_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 2
    Protein Accession:
    P55345
    Secondary Accessions:
    • B7U630
    • B7U631
    • B7U632
    • P78350
    • Q498Y5
    • Q5U7D4
    • Q6FHF0
    • Q99781
    • Q9BW15
    • Q9UMC2

    Protein attributes for PRMT2 Gene

    Size:
    433 amino acids
    Molecular mass:
    49042 Da
    Quaternary structure:
    • Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB. Interacts with HNRNPUL1.

    Three dimensional structures from OCA and Proteopedia for PRMT2 Gene

    Alternative splice isoforms for PRMT2 Gene

neXtProt entry for PRMT2 Gene

Post-translational modifications for PRMT2 Gene

  • Ubiquitination at Lys 124
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRMT2 Gene

Domains & Families for PRMT2 Gene

Gene Families for PRMT2 Gene

Protein Domains for PRMT2 Gene

Graphical View of Domain Structure for InterPro Entry

P55345

UniProtKB/Swiss-Prot:

ANM2_HUMAN :
  • Contains 1 SAM-dependent MTase PRMT-type domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT2: view

Function for PRMT2 Gene

Molecular function for PRMT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.6 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=3.3 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.4 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.5 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.

Enzyme Numbers (IUBMB) for PRMT2 Gene

Gene Ontology (GO) - Molecular Function for PRMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 12039952
GO:0004871 signal transducer activity TAS 9545638
GO:0005515 protein binding IPI 11513728
GO:0008168 methyltransferase activity IEA --
GO:0008469 histone-arginine N-methyltransferase activity ISS,IBA --
genes like me logo Genes that share ontologies with PRMT2: view
genes like me logo Genes that share phenotypes with PRMT2: view

Animal Models for PRMT2 Gene

MGI Knock Outs for PRMT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRMT2

miRNA for PRMT2 Gene

miRTarBase miRNAs that target PRMT2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT2 Gene

Localization for PRMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT2 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.
Isoform PRMT2Alpha: Nucleus. Note=Excluded from nucleolus.
Isoform PRMT2Beta: Cytoplasm. Nucleus. Nucleus, nucleolus.
Isoform PRMT2Gamma: Nucleus. Note=Excluded from nucleolus.
Isoform PRMT2L2: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT2 Gene COMPARTMENTS Subcellular localization image for PRMT2 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 11513728
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 11513728
GO:0005829 cytosol IDA 17587566
genes like me logo Genes that share ontologies with PRMT2: view

Pathways & Interactions for PRMT2 Gene

SuperPathways for PRMT2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
2 RB in Cancer
genes like me logo Genes that share pathways with PRMT2: view

Pathways by source for PRMT2 Gene

2 BioSystems pathways for PRMT2 Gene

Gene Ontology (GO) - Biological Process for PRMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IEA,TAS 9545638
GO:0007165 signal transduction TAS 9545638
GO:0016571 histone methylation ISS --
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 16648481
genes like me logo Genes that share ontologies with PRMT2: view

No data available for SIGNOR curated interactions for PRMT2 Gene

Drugs & Compounds for PRMT2 Gene

(2) Drugs for PRMT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with PRMT2: view

Transcripts for PRMT2 Gene

Unigene Clusters for PRMT2 Gene

Protein arginine methyltransferase 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ·
SP1: - -
SP2: -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10: - -
SP11: - -
SP12: - -
SP13: - - - -
SP14: - - - -
SP15: - -
SP16: - - - - - - - -
SP17:
SP18: - - - -
SP19: -
SP20: - -
SP21: - -
SP22: - - -
SP23:
SP24:

ExUns: 8d · 8e ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - - -
SP24:

Relevant External Links for PRMT2 Gene

GeneLoc Exon Structure for
PRMT2
ECgene alternative splicing isoforms for
PRMT2

Expression for PRMT2 Gene

mRNA expression in normal human tissues for PRMT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRMT2 Gene

This gene is overexpressed in Fetal Brain (19.3), Peripheral blood mononuclear cells (12.6), Testis (10.3), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRMT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRMT2 Gene:

PRMT2

SOURCE GeneReport for Unigene cluster for PRMT2 Gene:

Hs.154163

mRNA Expression by UniProt/SwissProt for PRMT2 Gene:

P55345-ANM2_HUMAN
Tissue specificity: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
genes like me logo Genes that share expression patterns with PRMT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PRMT2 Gene

Orthologs for PRMT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRMT2 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia HRMT1L1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT2 34 35
  • 85.37 (n)
mouse
(Mus musculus)
Mammalia Prmt2 34 16 35
  • 83.76 (n)
rat
(Rattus norvegicus)
Mammalia Prmt2 34
  • 83.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRMT2 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt2 34
  • 61.76 (n)
zebrafish
(Danio rerio)
Actinopterygii prmt2 34 35
  • 59.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Art8 35
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 35
  • 33 (a)
OneToMany
Species where no ortholog for PRMT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRMT2 Gene

ENSEMBL:
Gene Tree for PRMT2 (if available)
TreeFam:
Gene Tree for PRMT2 (if available)

Paralogs for PRMT2 Gene

Paralogs for PRMT2 Gene

genes like me logo Genes that share paralogs with PRMT2: view

Variants for PRMT2 Gene

Sequence variations from dbSNP and Humsavar for PRMT2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10222188 -- 46,641,192(+) ATCAC(A/C)TAAGC intron-variant
rs1047602 -- 46,636,346(+) GAATA(A/T)CACAA intron-variant
rs1053608 -- 46,665,459(+) ACAGT(G/T)CTAGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1054420 -- 46,659,551(+) AAATA(C/T)ATGAA intron-variant, utr-variant-3-prime
rs1054620 -- 46,659,998(+) ATATC(A/C)CAATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRMT2 Gene

Variant ID Type Subtype PubMed ID
dgv4441n100 CNV gain 25217958
dgv4442n100 CNV gain 25217958
dgv4443n100 CNV gain 25217958
dgv4444n100 CNV gain 25217958
dgv4446n100 CNV gain 25217958
dgv4447n100 CNV loss 25217958
dgv4448n100 CNV gain 25217958
dgv4449n100 CNV gain+loss 25217958
esv1540677 CNV insertion 17803354
esv2658047 CNV deletion 23128226
esv2758822 CNV gain 17122850
esv34393 CNV gain 17911159
esv3647171 CNV gain 21293372
esv3647172 CNV loss 21293372
esv3647173 CNV gain 21293372
esv3647174 CNV loss 21293372
nsv1059706 CNV gain 25217958
nsv1078938 CNV insertion 25765185
nsv1125229 CNV insertion 24896259
nsv1129228 CNV insertion 24896259
nsv1129684 CNV tandem duplication 24896259
nsv470910 CNV gain 18288195
nsv587999 CNV gain 21841781
nsv588002 CNV gain 21841781
nsv9864 CNV gain 18304495
nsv9865 CNV gain 18304495

Variation tolerance for PRMT2 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT2 Gene

Disorders for PRMT2 Gene

Relevant External Links for PRMT2

Genetic Association Database (GAD)
PRMT2
Human Genome Epidemiology (HuGE) Navigator
PRMT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT2

No disorders were found for PRMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRMT2 Gene

Publications for PRMT2 Gene

  1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott H.S. … Henry M.F. (Genomics 1998) 2 3 4 22 64
  2. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski T.M. … Frankel A. (Biochem. J. 2009) 3 4 22 64
  3. Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. (PMID: 9196002) Katsanis N. … Fisher E.M.C. (Mamm. Genome 1997) 3 4 22 64
  4. Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma. (PMID: 22093364) Zhong J. … Wen G.B. (FEBS J. 2012) 3 4 64
  5. Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. (PMID: 21820040) Zhong J. … Wen G.B. (Gene 2011) 3 4 64

Products for PRMT2 Gene

Sources for PRMT2 Gene

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