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PRMT1 Gene

protein-coding   GIFtS: 66
GCID: GC19P050181

Protein Arginine Methyltransferase 1

(Previous names: HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2, HMT1...)
(Previous symbol: HRMT1L2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Arginine Methyltransferase 11 2     HCP12
HRMT1L21 2 3 5     Heterogeneous Nuclear Ribonucleoprotein Methyltransferase 1-Like 22
IR1B42 3 5     Protein Arginine N-Methyltransferase 12
HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 21 2     EC 2.1.1.-3
Histone-Arginine N-Methyltransferase PRMT12 3     EC 2.1.1.1253
Interferon Receptor 1-Bound Protein 42 3     HMT23
HMT1 HnRNP Methyltransferase-Like 2 (S. Cerevisiae)1     EC 2.1.18
ANM12     EC 2.1.1.778

External Ids:    HGNC: 51871   Entrez Gene: 32762   Ensembl: ENSG000001264577   OMIM: 6029505   UniProtKB: Q998733   

Export aliases for PRMT1 gene to outside databases

Previous GC identifers: GC19P054873 GC19P046557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRMT1 Gene:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational
modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby
PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal
guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular
arginine methylation activity. Increased expression of this gene may play a role in many types of cancer.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a
pseudogene of this gene is located on the long arm of chromosome 5. (provided by RefSeq, Dec 2011)

GeneCards Summary for PRMT1 Gene:
PRMT1 (protein arginine methyltransferase 1) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity and identical protein binding. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot: ANM1_HUMAN, Q99873
Function: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens
of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP,
SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of
histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional
activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of
interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act
as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act
as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and
retains it in the nucleus increasing its transcriptional activity

Gene Wiki entry for PRMT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRMT1 gene promoter:
         STAT1   AP-1   p53   ATF-2   p300   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRMT1 promoter sequence
   Search Chromatin IP Primers for PRMT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13

PRMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRMT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050181:  view genomic region     (about GC identifiers)

Start:
50,179,043 bp from pter      End:
50,192,286 bp from pter
Size:
13,244 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANM1_HUMAN, Q99873 (See protein sequence)
Recommended Name: Protein arginine N-methyltransferase 1  
Size: 361 amino acids; 41516 Da
Subunit: Homodimer and heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer.
Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby
enabling the interaction of CHTOP with the 5FMC complex (By similarity). Interacts with ILF3 and SUPT5H.
Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1
transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress
Secondary accessions: B4E3C3 G5E9B6 Q15529 Q2VP93 Q6LEU5 Q8WUW5 Q99872 Q99874 Q9NZ04 Q9NZ05
Q9NZ06
Alternative splicing: 4 isoforms:  Q99873-1   Q99873-2   Q99873-3   Q99873-4   

Explore the universe of human proteins at neXtProt for PRMT1: NX_Q99873

Explore proteomics data for PRMT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys124, Lys173, Lys223, Lys233, Lys266, Lys303, Lys332
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRMT1 (Q99873) (see all 11)
     KVVLDVG  DYYFDSY  HEEMLKD  VLDVGSG 


    See PRMT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193971.1  NP_001527.3  NP_938074.2  

    ENSEMBL proteins: 
     ENSP00000432349   ENSP00000433556   ENSP00000432538   ENSP00000434911   ENSP00000431957  
     ENSP00000375724   ENSP00000432050   ENSP00000406162   ENSP00000433480   ENSP00000437273  
     ENSP00000432788   ENSP00000436732  

    PRMT1 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for PRMT1
    Novus Biologicals PRMT1 Proteins
    Novus Biologicals PRMT1 Lysates
    Sino Biological Recombinant Protein for PRMT1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRMT1
    Cloud-Clone Corp. Proteins for PRMT1

     
    Search eBioscience for Proteins for PRMT1 

     
    antibodies-online proteins for PRMT1 (43 products) 

     
    antibodies-online peptides for PRMT1

    PRMT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRMT1
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    ThermoFisher Antibody for PRMT1
    antibodies-online antibodies for PRMT1 (82 products) 

    PRMT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRMT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRMT1
    Cloud-Clone Corp. CLIAs for PRMT1
    Search eBioscience for ELISAs for PRMT1 
    antibodies-online kits for PRMT1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT1
    Protein arginine N-methyltransferases

    2 InterPro protein domains:
     IPR025714 Methyltranfer_dom
     IPR025799 Arg_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q99873

    ProtoNet protein and cluster: Q99873

    UniProtKB/Swiss-Prot: ANM1_HUMAN, Q99873
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine
    N-methyltransferase family
    Similarity: Contains 1 SAM-dependent MTase PRMT-type domain


    Find genes that share domains with PRMT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANM1_HUMAN, Q99873
    Function: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens
    of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP,
    SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of
    histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional
    activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of
    interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act
    as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act
    as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and
    retains it in the nucleus increasing its transcriptional activity
    Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine +
    N(omega)-methyl-arginine-[histone]
    Enzyme regulation: By BTG1, BTG2 and ILF3
    Biophysicochemical properties: Kinetic parameters: KM=1 uM for AdoMet; KM=4.2 uM for H4; Vmax=1.2 nmol/min/mg
    enzyme toward AdoMet; Vmax=1.24 nmol/min/mg enzyme toward H4;

         Enzyme Numbers (IUBMB): EC 2.1.1.772 EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.1251

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10749851
    GO:0008168methyltransferase activity TAS9545638
    GO:0008170N-methyltransferase activity IMP19124016
    GO:0008276protein methyltransferase activity ----
    GO:0008469histone-arginine N-methyltransferase activity ----
         
    Find genes that share ontologies with PRMT1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRMT1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased S DNA content  Increased cell size 
     Increased gamma-H2AX phosphory  Nuclear pre-40S maturation def 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prmt1):
     cellular  embryogenesis  homeostasis/metabolism  mortality/aging  no phenotypic analysis 
     reproductive system 

    Find genes that share phenotypes with PRMT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prmt1tm1.1Rchd for PRMT1

       genOway: Develop your customized and physiologically relevant rodent model for PRMT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRMT1:
    hsa-mir-877-3p (MIRT037074), hsa-mir-30a-5p (MIRT028512), hsa-mir-378a-5p (MIRT043993)

    Block miRNA regulation of human, mouse, rat PRMT1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PRMT1:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRMT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRMT1
    Predesigned siRNA for gene silencing in human, mouse, rat PRMT1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PRMT1 (see all 18)
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT1 (NM_198318)
    Sino Biological Human cDNA Clone for PRMT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRMT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRMT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANM1_HUMAN, Q99873: Nucleus. Nucleus, nucleoplasm (By similarity). Cytoplasm, cytosol (By similarity).
    Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the
    chromatin fraction (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10749851
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm TAS9029147
    GO:0005829cytosol IBA--
    GO:0043234protein complex ----

    Find genes that share ontologies with PRMT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRMT1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    3mRNA Splicing - Major Pathway
    mRNA processing0.44
    4Packaging Of Telomere Ends
    Histone modification0.31
    5Interferon type I
    Interferon type I


    Find genes that share SuperPaths with PRMT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRMT1
        Nuclear Receptor Activation by Vitamin-A
    Cell Cycle Control by BTG Proteins
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for PRMT1
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for PRMT1
        Immune response IFN alpha/beta signaling pathway

    5 BioSystems Pathways for PRMT1
        mRNA processing
    Interferon type I
    Energy Metabolism
    Direct p53 effectors
    Tryptophan metabolism



    1 Kegg Pathway  (Kegg details for PRMT1):
        FoxO signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRMT1

    Selected Interacting proteins for PRMT1 (Q998731, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 207)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=6 
    HIST1H4BP628053I2D: score=6 
    HIST1H4CP628053I2D: score=6 
    HIST1H4DP628053I2D: score=6 
    HIST1H4EP628053I2D: score=6 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ----
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006479protein methylation TAS9545638
    GO:0007166cell surface receptor signaling pathway TAS9029147
    GO:0008152metabolic process ----

    Find genes that share ontologies with PRMT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRMT1 (ANM1)

    1 DrugBank Compound for PRMT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235

    10 Novoseek inferred chemical compound relationships for PRMT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 87.4 206 18316480 (4), 19136629 (4), 19158082 (3), 19078953 (3) (see all 89)
    adma 70.3 3 18771293 (1), 19833096 (1), 19822957 (1)
    s-adenosylmethionine 66.5 6 19405910 (1), 17191129 (1)
    s-adenosylhomocysteine 61.5 4 17960915 (1), 19733141 (1)
    lysine 47.1 2 19596784 (1), 20219369 (1)
    estrogen 18 5 16861234 (3), 18657504 (1)
    retinoid 12.3 4 15525597 (1), 15964820 (1)
    steroid 8.67 8 19183483 (1), 15525597 (1), 11097842 (1)
    tyrosine 0 2 18492485 (1), 16492668 (1)
    cyclic amp 0 2 15525597 (1)



    Find genes that share compounds with PRMT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRMT1 gene (4 alternative transcripts): 
    NM_001207042.2  NM_001536.5  NM_198318.4  NM_198319.2  

    Unigene Cluster for PRMT1:

    Protein arginine methyltransferase 1
    Hs.20521  [show with all ESTs]
    Unigene Representative Sequence: AK295973
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000529284 ENST00000532489 ENST00000527382 ENST00000528623 ENST00000534465
    ENST00000391851(uc021uxu.1 uc010enf.2 uc002ppe.3 uc021uxv.1)
    ENST00000534280 ENST00000534676(uc010yba.2) ENST00000525915 ENST00000454376
    ENST00000525616 ENST00000524771 ENST00000529836 ENST00000526224 ENST00000527412
    ENST00000529650 ENST00000530070 ENST00000530361
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    6 qRT-PCR Assays for microRNAs that regulate PRMT1:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548d-3p hsa-miR-548x hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRMT1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRMT1 (NM_198318)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRMT1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PRMT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRMT1
      QuantiTect SYBR Green Assays in human, mouse, rat PRMT1
      QuantiFast Probe-based Assays in human, mouse, rat PRMT1

    Additional mRNA sequence: 

    AF085918.1 AK295973.1 AK301038.1 AK304660.1 AY775289.1 BC019268.1 BC109282.1 BC109283.2 
    CR407608.1 D66904.1 NR_033397.4 Y10805.1 Y10806.1 Y10807.1 

    Selected DOTS entries (see all 34):

    DT.100887218  DT.454147  DT.92458443  DT.100039192  DT.121443718  DT.95371958  DT.100887214  DT.100887213 
    DT.100832963  DT.95371948  DT.100039186  DT.95371959  DT.97860934  DT.100039187  DT.101980192  DT.100887220 
    DT.92058762  DT.95371946  DT.95371947  DT.121443779  DT.95305445  DT.100887224  DT.100887228  DT.121443908 

    Selected AceView cDNA sequences (see all 738):

    BI862070 BU178551 AW245999 BE784370 BE792327 BI222559 BQ636868 BI087440 
    BF796122 CR620963 BM970949 CR618569 BQ434963 CF144839 CA841973 BU686037 
    BU507588 AW245553 BU152869 H52143 BQ933715 AA295851 BQ942575 CR614514 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRMT1 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ·
    SP1:                                                                                -     -           -     -     -                                   -         
    SP2:                                                                                -     -     -     -     -     -                                   -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                -     -     -     -     -     -                                   -         
    SP5:                                                                                      -           -     -     -                                   -         

    ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                            -     -                           
    SP2:                                            -     -                           
    SP3:                                            -     -                           
    SP4:              -     -     -     -     -     -     -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for PRMT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCCCAACG
    PRMT1 Expression
    About this image


    PRMT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    PRMT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRMT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20521

    UniProtKB/Swiss-Prot: ANM1_HUMAN, Q99873
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including PRMT1: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRMT1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prmt11 , 5 protein arginine N-methyltransferase 11, 5 92.36(n)1
    99.73(a)1
      7 (29.07 cM)5
    154691  NM_019830.31  NP_062804.11 
     449759895 
    lizard
    (Anolis carolinensis)
    Reptilia PRMT16
    protein arginine methyltransferase 1
    95(a)
    1 ↔ 1
    GL343287.1(83111-106628)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232952 Xenopus laevis, Similar to heterogeneous nuclear ribonucleoproteins more 81.32(n)    AB085173.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662012 hypothetical protein MGC66201 79.96(n)   393623  BC044522.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Art11 Arginine methyltransferase 1 68.95(n)
    66.3(a)
      41295  NM_141760.3  NP_650017.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prmt-11 prmt-1 67.37(n)
    68.18(a)
      180326  NM_075508.4  NP_507909.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HMT11 HMT1 55.05(n)
    51.29(a)
      852322   NP_009590.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRMT1A1 PRMT1A 58.84(n)
    58.54(a)
      816486  NM_127525.4  NP_179557.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03598001 Os09g0359800 59.16(n)
    58.77(a)
      4346843  NM_001069510.1  NP_001062975.1 


    ENSEMBL Gene Tree for PRMT1 (if available)
    TreeFam Gene Tree for PRMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRMT1 gene
    PRMT62  PRMT32  CARM12  PRMT22  PRMT82  
    7 SIMAP similar genes for PRMT1 using alignment to 11 protein entries:     ANM1_HUMAN (see all proteins):
    PRMT8    HRMT1L2    PRMT3    CARM1    PRMT2    PRMT6
    PRMT7

    Find genes that share paralogs with PRMT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRMT1
    PGOHUM00000258198


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRMT1 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461659181,2
    --50355322(+) CCTGAA/TGTGCA 4 -- us2k10--------
    rs735884131,2
    C,F--50355371(+) TGGAAC/ACAAAT 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1835455101,2
    C--50355561(+) GGCGTG/TTGCCA 4 -- us2k10--------
    rs1861429741,2
    --50356100(+) TCGACC/TTCCTG 4 -- us2k10--------
    rs1172825691,2
    C,F--50356234(+) AGACTG/AGTCTC 4 -- us2k11Minor allele frequency- A:0.08EA 120
    rs1437684751,2
    --50356299(+) ACACCC/GGTGAG 4 -- us2k10--------
    rs1447933181,2
    --50356334(+) AATTTC/TAAGTC 4 -- us2k10--------
    rs175512621,2
    C,F--50356450(+) GTAGAG/CGGATC 4 -- us2k11Minor allele frequency- C:0.03EA 120
    rs798615031,2
    C,F--50356535(+) AATCAA/GGGAAA 4 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1900602611,2
    C--50356589(+) TTTAGA/GAGCTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRMT1 (50179043 - 50192286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRMT1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912269CNV Loss21882294
    esv24796CNV Loss19812545
    dgv3972n71CNV Loss21882294
    nsv828578CNV Loss20364138
    nsv470150CNV Gain18288195
    nsv833864CNV Gain17160897
    nsv817854CNV Gain17921354
    nsv9739CNV Gain+Loss18304495
    nsv833865CNV Gain+Loss17160897
    nsv469715CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRMT1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRMT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602950    OMIM disorders: --


    Find genes that share disorders with PRMT1           About GenesLikeMe

    5 Novoseek inferred disease relationships for PRMT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 50.1 1 16044463 (1)
    hepatitis c chronic 13.6 3 20043320 (1)
    hepatitis c 9.64 2 11483748 (1), 16306605 (1)
    breast cancer 9.01 11 19183483 (1), 17848568 (1), 19170758 (1), 15525597 (1) (see all 5)
    cancer 6.56 10 19596784 (2), 19085993 (1), 17891136 (1)

    Genetic Association Database (GAD): PRMT1
    Human Genome Epidemiology (HuGE) Navigator: PRMT1 (3 documents)

    Export disorders for PRMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRMT1 gene, integrated from 10 sources (see all 230):
    (articles sorted by number of sources associating them with PRMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PubMed id 9545638)1, 2, 3, 9 Scott H.S....Henry M.F. (Genomics 1998)
    2. Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene. (PubMed id 11097842)1, 2, 9 Scorilas A.... Diamandis E.P. (Biochem. Biophys. Res. Commun. 2000)
    3. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PubMed id 19124016)1, 2, 9 Jobert L.... Tora L. (Exp. Cell Res. 2009)
    4. PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. (PubMed id 18773938)1, 2, 9 Miyata S.... Tohyama M. (Neurosci. Lett. 2008)
    5. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PubMed id 19405910)1, 2, 9 Lakowski T.M. and Frankel A. (Biochem. J. 2009)
    6. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PubMed id 11387442)1, 2, 9 Wang H.... Zhang Y. (Science 2001)
    7. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. (PubMed id 18657504)1, 2, 9 Le Romancer M....Corbo L. (Mol. Cell 2008)
    8. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PubMed id 19183483)1, 4, 9 Haiman C.A....Press M.F. (BMC Cancer 2009)
    9. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. (PubMed id 11448779)1, 2, 9 Strahl B.D.... Allis C.D. (Curr. Biol. 2001)
    10. Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. (PubMed id 20442406)1, 2 Chang Y.I.... Lin W.J. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3276 HGNC: 5187 AceView: HRMT1L2 Ensembl:ENSG00000126457 euGenes: HUgn3276
    ECgene: PRMT1 Kegg: 3276 H-InvDB: PRMT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRMT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRMT1 gene:
    Search GeneIP for patents involving PRMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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