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Aliases for PRM2 Gene

Aliases for PRM2 Gene

  • Protamine 2 2 3 5
  • Sperm Protamine P2 3 4
  • Sperm Histone P2 3 4
  • Cancer/Testis Antigen Family 94, Member 2 3
  • Testicular Secretory Protein Li 40 3
  • Cancer/Testis Antigen Family 94 2
  • Member 2 2
  • CT94.2 3

External Ids for PRM2 Gene

Previous GeneCards Identifiers for PRM2 Gene

  • GC16M011143
  • GC16M011520
  • GC16M011335
  • GC16M011276
  • GC16M011369
  • GC16M011287
  • GC16M011283
  • GC16M011288

Summaries for PRM2 Gene

Entrez Gene Summary for PRM2 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for PRM2 Gene

PRM2 (Protamine 2) is a Protein Coding gene. Diseases associated with PRM2 include male infertility and male reproductive system disease.

UniProtKB/Swiss-Prot for PRM2 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRM2 Gene

Genomics for PRM2 Gene

Regulatory Elements for PRM2 Gene

Genomic Location for PRM2 Gene

Chromosome:
16
Start:
11,275,636 bp from pter
End:
11,276,480 bp from pter
Size:
845 bases
Orientation:
Minus strand

Genomic View for PRM2 Gene

Genes around PRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRM2 Gene

Proteins for PRM2 Gene

  • Protein details for PRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04554-PRM2_HUMAN
    Recommended name:
    Protamine-2
    Protein Accession:
    P04554
    Secondary Accessions:
    • Q6ZMM0

    Protein attributes for PRM2 Gene

    Size:
    102 amino acids
    Molecular mass:
    13051 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRM2 Gene

    Alternative splice isoforms for PRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRM2 Gene

Proteomics data for PRM2 Gene at MOPED

Post-translational modifications for PRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRM2 Gene

No data available for DME Specific Peptides for PRM2 Gene

Domains & Families for PRM2 Gene

Protein Domains for PRM2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P04554

UniProtKB/Swiss-Prot:

PRM2_HUMAN :
  • Belongs to the protamine P2 family.
Family:
  • Belongs to the protamine P2 family.
genes like me logo Genes that share domains with PRM2: view

No data available for Gene Families for PRM2 Gene

Function for PRM2 Gene

Molecular function for PRM2 Gene

GENATLAS Biochemistry:
protamine 2
UniProtKB/Swiss-Prot Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
genes like me logo Genes that share phenotypes with PRM2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM2 Gene

Localization for PRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRM2 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRM2 Gene COMPARTMENTS Subcellular localization image for PRM2 gene
Compartment Confidence
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PRM2 Gene

Pathways & Interactions for PRM2 Gene

SuperPathways for PRM2 Gene

No Data Available

Interacting Proteins for PRM2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000241808%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000369445%0d%0a
Selected Interacting proteins: ENSP00000241808 for PRM2 Gene via STRING

Gene Ontology (GO) - Biological Process for PRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 2081589
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,TAS 2081589
GO:0030261 chromosome condensation IBA --
genes like me logo Genes that share ontologies with PRM2: view

No data available for Pathways by source and SIGNOR curated interactions for PRM2 Gene

Drugs & Compounds for PRM2 Gene

(1) Additional Compounds for PRM2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRM2: view

Transcripts for PRM2 Gene

Unigene Clusters for PRM2 Gene

Protamine 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRM2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PRM2 Gene

GeneLoc Exon Structure for
PRM2
ECgene alternative splicing isoforms for
PRM2

Expression for PRM2 Gene

mRNA expression in normal human tissues for PRM2 Gene

mRNA differential expression in normal tissues according to GTEx for PRM2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for PRM2 Gene

This gene is overexpressed in Ovary (37.3) and Testis (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRM2 Gene



SOURCE GeneReport for Unigene cluster for PRM2 Gene Hs.2324

mRNA Expression by UniProt/SwissProt for PRM2 Gene

P04554-PRM2_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with PRM2: view

Protein tissue co-expression partners for PRM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRM2 Gene

Orthologs for PRM2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRM2 36
  • 93 (a)
OneToOne
Species with no ortholog for PRM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRM2 Gene

ENSEMBL:
Gene Tree for PRM2 (if available)
TreeFam:
Gene Tree for PRM2 (if available)

Paralogs for PRM2 Gene

No data available for Paralogs for PRM2 Gene

Variants for PRM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRM2 Gene

Variant ID Type Subtype PubMed ID
nsv510412 CNV Loss 20534489

Variation tolerance for PRM2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRM2 Gene

HapMap Linkage Disequilibrium report
PRM2
Human Gene Mutation Database (HGMD)
PRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PRM2 Gene

Disorders for PRM2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PRM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
male reproductive system disease
  • genital diseases, male
progressive relapsing multiple sclerosis
  • prms
pelvic varices
reproductive system disease
  • genital system disease
- elite association - COSMIC cancer census association via MalaCards
Search PRM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRM2

Genetic Association Database (GAD)
PRM2
Human Genome Epidemiology (HuGE) Navigator
PRM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRM2
genes like me logo Genes that share disorders with PRM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRM2 Gene

Publications for PRM2 Gene

  1. Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations. (PMID: 12569175) Tanaka H. … Nishimune Y. (Mol. Hum. Reprod. 2003) 3 23 48 67
  2. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) TA1ttelmann F. … Simoni M. (Int. J. Androl. 2010) 3 23
  3. Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L. … McElreavey K. (Mol. Hum. Reprod. 2009) 3 23
  4. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PMID: 18292840) Depa-MartynA^w M. … Jedrzejczak P. (Folia Histochem. Cytobiol. 2007) 3 23
  5. Identification of genetic variation in the 5' and 3' non-coding regions of the protamine genes in patients with protamine deregulation. (PMID: 18309899) Hammoud S. … Carrell D.T. (Arch. Androl. 2007) 3 23

Products for PRM2 Gene

Sources for PRM2 Gene

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