Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRM1 Gene

Aliases for PRM1 Gene

  • Protamine 1 2 3 5
  • Cancer/Testis Antigen Family 94, Member 1 2 3
  • Cysteine-Rich Protamine 3 4
  • Testicular Tissue Protein Li 91 3
  • Testis Specific Protamine 1 3
  • Sperm Protamine P1 3
  • CT94.1 3
  • P1 3

External Ids for PRM1 Gene

Previous GeneCards Identifiers for PRM1 Gene

  • GC16M011149
  • GC16M011526
  • GC16M011341
  • GC16M011282
  • GC16M011374
  • GC16M011292
  • GC16M011285
  • GC16M011289
  • GC16M011293
  • GC16M011296

Summaries for PRM1 Gene

GeneCards Summary for PRM1 Gene

PRM1 (Protamine 1) is a Protein Coding gene. Diseases associated with PRM1 include Male Infertility and Pelvic Varices.

UniProtKB/Swiss-Prot for PRM1 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRM1 Gene

Genomics for PRM1 Gene

Regulatory Elements for PRM1 Gene

Enhancers for PRM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G011291 0.4 FANTOM5 12.1 -9.2 -9178 0.1 MAZ ZMYM3 TNP2 PRM2 PRM3 PRM1 CLEC16A PIR58691
GH16G011279 1 ENCODE 0.7 +1.6 1552 0.2 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 MXD4 PPARG KAT8 SSRP1 PRM1 PRM2
GH16G011280 0.7 ENCODE 0.7 +2.0 2012 0.2 GATAD2A NFYC ZNF384 ZIC2 ZNF48 ZFHX2 ZKSCAN8 MXD3 U2AF1 RBFOX2 PRM1 PRM2
GH16G011293 0.9 ENCODE 0.4 -12.1 -12149 0.2 ELF3 ARID4B RAD21 ZNF48 RARA CREM MXD4 KAT8 ZNF217 TGIF2 PIR58691 PRM1
GH16G011290 0.5 ENCODE 0.4 -10.1 -10122 1.0 OSR2 RNF2 ZIC2 TEAD3 RMI2 PIR58691 PRM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRM1 Gene

Chromosome:
16
Start:
11,280,836 bp from pter
End:
11,281,350 bp from pter
Size:
515 bases
Orientation:
Minus strand

Genomic View for PRM1 Gene

Genes around PRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRM1 Gene

Proteins for PRM1 Gene

  • Protein details for PRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04553-HSP1_HUMAN
    Recommended name:
    Sperm protamine P1
    Protein Accession:
    P04553

    Protein attributes for PRM1 Gene

    Size:
    51 amino acids
    Molecular mass:
    6823 Da
    Quaternary structure:
    • Cross-linked by interchain disulfide bonds around the DNA-helix.

    Three dimensional structures from OCA and Proteopedia for PRM1 Gene

neXtProt entry for PRM1 Gene

Post-translational modifications for PRM1 Gene

Other Protein References for PRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRM1 Gene

Domains & Families for PRM1 Gene

Protein Domains for PRM1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04553

UniProtKB/Swiss-Prot:

HSP1_HUMAN :
  • Belongs to the protamine P1 family.
Family:
  • Belongs to the protamine P1 family.
genes like me logo Genes that share domains with PRM1: view

No data available for Gene Families for PRM1 Gene

Function for PRM1 Gene

Molecular function for PRM1 Gene

GENATLAS Biochemistry:
protamine 1
UniProtKB/Swiss-Prot Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

Gene Ontology (GO) - Molecular Function for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS,IEA --
genes like me logo Genes that share ontologies with PRM1: view
genes like me logo Genes that share phenotypes with PRM1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM1 Gene

Localization for PRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRM1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRM1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS 2081589
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PRM1: view

Pathways & Interactions for PRM1 Gene

No Data Available

Interacting Proteins for PRM1 Gene

Gene Ontology (GO) - Biological Process for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 2081589
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0030154 cell differentiation IEA --
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with PRM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRM1 Gene

Drugs & Compounds for PRM1 Gene

(2) Drugs for PRM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for PRM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRM1: view

Transcripts for PRM1 Gene

mRNA/cDNA for PRM1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(140) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRM1 Gene

Protamine 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRM1 Gene

No ASD Table

Relevant External Links for PRM1 Gene

GeneLoc Exon Structure for
PRM1
ECgene alternative splicing isoforms for
PRM1

Expression for PRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRM1 Gene

mRNA differential expression in normal tissues according to GTEx for PRM1 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of PRM1 Gene:

PRM1

SOURCE GeneReport for Unigene cluster for PRM1 Gene:

Hs.2909

mRNA Expression by UniProt/SwissProt for PRM1 Gene:

P04553-HSP1_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with PRM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRM1 Gene

Orthologs for PRM1 Gene

Evolution for PRM1 Gene

ENSEMBL:
Gene Tree for PRM1 (if available)
TreeFam:
Gene Tree for PRM1 (if available)

No data available for Orthologs for PRM1 Gene

Paralogs for PRM1 Gene

(1) SIMAP similar genes for PRM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRM1: view

No data available for Paralogs for PRM1 Gene

Variants for PRM1 Gene

Sequence variations from dbSNP and Humsavar for PRM1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000597076 -- 11,281,510(+) GGGGC(A/G)ATACA intron-variant, upstream-variant-2KB
rs1001032733 -- 11,281,347(+) CAGCT(A/C)TGCGG intron-variant, upstream-variant-2KB
rs1001106297 -- 11,281,200(+) TATCT(A/G)CTCCG intron-variant, reference, synonymous-codon
rs1001366235 -- 11,282,222(+) AACCT(A/C/G)GGGTT intron-variant, upstream-variant-2KB
rs1002296372 -- 11,280,709(+) GTGAC(A/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRM1 Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571453 CNV loss 21841781

Variation tolerance for PRM1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRM1 Gene

Human Gene Mutation Database (HGMD)
PRM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRM1 Gene

Disorders for PRM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PRM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
pelvic varices
male reproductive system disease
  • genital diseases, male
reproductive system disease
  • genital system disease
infertility
- elite association - COSMIC cancer census association via MalaCards
Search PRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRM1

Genetic Association Database (GAD)
PRM1
Human Genome Epidemiology (HuGE) Navigator
PRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRM1
genes like me logo Genes that share disorders with PRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRM1 Gene

Publications for PRM1 Gene

  1. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) TA1ttelmann F. … Simoni M. (Int. J. Androl. 2010) 3 22 46 64
  2. Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L. … McElreavey K. (Mol. Hum. Reprod. 2009) 3 22 46 64
  3. A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. (PMID: 18390561) GA!zquez C. … Oliva R. (J. Androl. 2008) 3 22 46 64
  4. Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki V.W. … Carrell D.T. (Fertil. Steril. 2006) 3 22 46 64
  5. Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered. (PMID: 2081589) Domenjoud L. … Engel W. (Genomics 1990) 3 4 22 64

Products for PRM1 Gene

Sources for PRM1 Gene

Content
Loading form....