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Aliases for PRM1 Gene

Aliases for PRM1 Gene

  • Protamine 1 2 3 5
  • Cysteine-Rich Protamine 3 4
  • Cancer/Testis Antigen Family 94, Member 1 3
  • Cancer/Testis Antigen Family 94 2
  • Testicular Tissue Protein Li 91 3
  • Testis Specific Protamine 1 3
  • Member 1 2
  • CT94.1 3
  • P1 3

External Ids for PRM1 Gene

Previous GeneCards Identifiers for PRM1 Gene

  • GC16M011149
  • GC16M011526
  • GC16M011341
  • GC16M011282
  • GC16M011374
  • GC16M011292
  • GC16M011285
  • GC16M011289

Summaries for PRM1 Gene

GeneCards Summary for PRM1 Gene

PRM1 (Protamine 1) is a Protein Coding gene. Diseases associated with PRM1 include Male Infertility and Pelvic Varices.

UniProtKB/Swiss-Prot for PRM1 Gene

  • Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRM1 Gene

Genomics for PRM1 Gene

Regulatory Elements for PRM1 Gene

Enhancers for PRM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRM1 Gene

Chromosome:
16
Start:
11,280,836 bp from pter
End:
11,281,350 bp from pter
Size:
515 bases
Orientation:
Minus strand

Genomic View for PRM1 Gene

Genes around PRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRM1 Gene

Proteins for PRM1 Gene

  • Protein details for PRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04553-HSP1_HUMAN
    Recommended name:
    Sperm protamine P1
    Protein Accession:
    P04553

    Protein attributes for PRM1 Gene

    Size:
    51 amino acids
    Molecular mass:
    6823 Da
    Quaternary structure:
    • Cross-linked by interchain disulfide bonds around the DNA-helix.

    Three dimensional structures from OCA and Proteopedia for PRM1 Gene

neXtProt entry for PRM1 Gene

Proteomics data for PRM1 Gene at MOPED

Post-translational modifications for PRM1 Gene

Other Protein References for PRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRM1 Gene

Domains & Families for PRM1 Gene

Protein Domains for PRM1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04553

UniProtKB/Swiss-Prot:

HSP1_HUMAN :
  • Belongs to the protamine P1 family.
Family:
  • Belongs to the protamine P1 family.
genes like me logo Genes that share domains with PRM1: view

No data available for Gene Families for PRM1 Gene

Function for PRM1 Gene

Molecular function for PRM1 Gene

GENATLAS Biochemistry:
protamine 1
UniProtKB/Swiss-Prot Function:
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
genes like me logo Genes that share phenotypes with PRM1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRM1 Gene

Localization for PRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRM1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRM1 Gene COMPARTMENTS Subcellular localization image for PRM1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PRM1 Gene

Pathways & Interactions for PRM1 Gene

SuperPathways for PRM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS 2081589
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,TAS 2081589
GO:0030261 chromosome condensation IBA --
genes like me logo Genes that share ontologies with PRM1: view

No data available for Pathways by source and SIGNOR curated interactions for PRM1 Gene

Drugs & Compounds for PRM1 Gene

(2) Drugs for PRM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for PRM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRM1: view

Transcripts for PRM1 Gene

mRNA/cDNA for PRM1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(140) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRM1 Gene

Protamine 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRM1 Gene

No ASD Table

Relevant External Links for PRM1 Gene

GeneLoc Exon Structure for
PRM1
ECgene alternative splicing isoforms for
PRM1

Expression for PRM1 Gene

mRNA expression in normal human tissues for PRM1 Gene

mRNA differential expression in normal tissues according to GTEx for PRM1 Gene

This gene is overexpressed in Testis (x52.7).

SOURCE GeneReport for Unigene cluster for PRM1 Gene Hs.2909

mRNA Expression by UniProt/SwissProt for PRM1 Gene

P04553-HSP1_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with PRM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRM1 Gene

Orthologs for PRM1 Gene

Evolution for PRM1 Gene

ENSEMBL:
Gene Tree for PRM1 (if available)
TreeFam:
Gene Tree for PRM1 (if available)

No data available for Orthologs for PRM1 Gene

Paralogs for PRM1 Gene

(1) SIMAP similar genes for PRM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRM1: view

No data available for Paralogs for PRM1 Gene

Variants for PRM1 Gene

Variation tolerance for PRM1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRM1 Gene

Human Gene Mutation Database (HGMD)
PRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for PRM1 Gene

Disorders for PRM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PRM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
pelvic varices
male reproductive system disease
  • genital diseases, male
reproductive system disease
  • genital system disease
infertility
- elite association - COSMIC cancer census association via MalaCards
Search PRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRM1

Genetic Association Database (GAD)
PRM1
Human Genome Epidemiology (HuGE) Navigator
PRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRM1
genes like me logo Genes that share disorders with PRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRM1 Gene

Publications for PRM1 Gene

  1. A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. (PMID: 19863670) TA1ttelmann F. … Simoni M. (Int. J. Androl. 2010) 3 23 48 67
  2. Mutations in the protamine locus: association with spermatogenic failure? (PMID: 19602509) Imken L. … McElreavey K. (Mol. Hum. Reprod. 2009) 3 23
  3. A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. (PMID: 18390561) GA!zquez C. … Oliva R. (J. Androl. 2008) 3 23
  4. Mutations in the protamine 1 gene associated with male infertility. (PMID: 17494104) Ravel C. … McElreavey K. (Mol. Hum. Reprod. 2007) 3 23
  5. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PMID: 18292840) Depa-MartynA^w M. … Jedrzejczak P. (Folia Histochem. Cytobiol. 2007) 3 23

Products for PRM1 Gene

Sources for PRM1 Gene

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