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Aliases for PRLHR Gene

Aliases for PRLHR Gene

  • Prolactin Releasing Hormone Receptor 2 3
  • GPR10 3 4 6
  • G Protein-Coupled Receptor 10 2 3
  • G-Protein Coupled Receptor 10 3 4
  • PrRP Receptor 3 4
  • PrRPR 3 4
  • HGR3 3 4
  • GR3 3 4
  • Prolactin Releasing Peptide Receptor 3
  • Prolactin-Releasing Hormone Receptor 3
  • Prolactin-Releasing Peptide Receptor 3

External Ids for PRLHR Gene

Previous Symbols for PRLHR Gene

  • GPR10

Summaries for PRLHR Gene

Entrez Gene Summary for PRLHR Gene

  • PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRLHR Gene

PRLHR (Prolactin Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with PRLHR include uterine fibroid. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for PRLHR Gene

  • Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing

Gene Wiki entry for PRLHR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLHR Gene

Genomics for PRLHR Gene

Genomic Location for PRLHR Gene

Start:
118,589,989 bp from pter
End:
118,595,699 bp from pter
Size:
5,711 bases
Orientation:
Minus strand

Genomic View for PRLHR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRLHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLHR Gene

Regulatory Elements for PRLHR Gene

Proteins for PRLHR Gene

  • Protein details for PRLHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49683-PRLHR_HUMAN
    Recommended name:
    Prolactin-releasing peptide receptor
    Protein Accession:
    P49683
    Secondary Accessions:
    • O75194
    • Q502U8
    • Q5VXR9

    Protein attributes for PRLHR Gene

    Size:
    370 amino acids
    Molecular mass:
    41121 Da
    Quaternary structure:
    • Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
    SequenceCaution:
    • Sequence=AAC50504.1; Type=Frameshift; Positions=168, 175; Evidence={ECO:0000305};

neXtProt entry for PRLHR Gene

Proteomics data for PRLHR Gene at MOPED

Post-translational modifications for PRLHR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn27 and Asn36

Other Protein References for PRLHR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLHR Gene

Domains for PRLHR Gene

Gene Families for PRLHR Gene

HGNC:
  • RFAPR :GPCR / Class A : RF amide peptide receptors
IUPHAR :

UniProtKB/Swiss-Prot:

PRLHR_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P49683
genes like me logo Genes that share domains with PRLHR: view

Function for PRLHR Gene

Molecular function for PRLHR Gene

UniProtKB/Swiss-Prot Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing
UniProtKB/Swiss-Prot Induction: Repressed by bromocriptine, a dopamine agonist.

Gene Ontology (GO) - Molecular Function for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8666380
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 11641419
GO:0008188 neuropeptide receptor activity TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view
genes like me logo Genes that share phenotypes with PRLHR: view

Animal Models for PRLHR Gene

MGI Knock Outs for PRLHR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PRLHR Gene

Localization for PRLHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRLHR Gene COMPARTMENTS Subcellular localization image for PRLHR gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8666380
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PRLHR: view

Pathways for PRLHR Gene

genes like me logo Genes that share pathways with PRLHR: view

Pathways by source for PRLHR Gene

Gene Ontology (GO) - Biological Process for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 8666380
GO:0007218 neuropeptide signaling pathway TAS 9607765
GO:0007565 female pregnancy TAS 9607765
GO:0007631 feeding behavior IEA --
GO:0042445 hormone metabolic process IEA --
genes like me logo Genes that share ontologies with PRLHR: view

Compounds for PRLHR Gene

(10) IUPHAR Ligand for PRLHR Gene

Ligand Type Action Affinity Pubmed IDs
[125I]PrRP-20 (human) Agonist Full agonist 10.6
PrRP-20 Agonist Full agonist 9.7
PrRP-20 Agonist Full agonist 9.7
PrRP-31 Agonist Full agonist 9.5
PrRP-31 Agonist Full agonist 9.5
neuropeptide Y Agonist Full agonist 9.1
PrRP-(24-31) (human) Agonist Full agonist 7.3
NPY-(18-36) (human, pig) Agonist Full agonist 6.2
[125I]PrRP31 None None
PTHrP Agonist Full agonist

(1) Novoseek inferred chemical compound relationships for PRLHR Gene

Compound -log(P) Hits PubMed IDs
glutamate 5.8 1
genes like me logo Genes that share compounds with PRLHR: view

Transcripts for PRLHR Gene

mRNA/cDNA for PRLHR Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRLHR Gene

Prolactin releasing hormone receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRLHR Gene

No ASD Table

Relevant External Links for PRLHR Gene

GeneLoc Exon Structure for
PRLHR
ECgene alternative splicing isoforms for
PRLHR

Expression for PRLHR Gene

mRNA expression in normal human tissues for PRLHR Gene

mRNA differential expression in normal tissues according to GTEx for PRLHR Gene

This gene is overexpressed in Pituitary (15.6), Vagina (6.7), Uterus (5.2), and Brain - Hypothalamus (4.3).

SOURCE GeneReport for Unigene cluster for PRLHR Gene Hs.248119

mRNA Expression by UniProt/SwissProt for PRLHR Gene

P49683-PRLHR_HUMAN
Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas.
genes like me logo Genes that share expressions with PRLHR: view

Orthologs for PRLHR Gene

This gene was present in the common ancestor of animals.

Orthologs for PRLHR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRLHR 36
  • 99.55 (n)
  • 99.46 (a)
PRLHR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRLHR 36
  • 90.27 (n)
  • 91.89 (a)
PRLHR 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRLHR 36
  • 91.62 (n)
  • 94.86 (a)
PRLHR 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prlhr 36
  • 86.19 (n)
  • 90.74 (a)
Prlhr 16
Prlhr 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRLHR 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Prlhr 36
  • 86.45 (n)
  • 91.21 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 55 (a)
OneToMany
PRLHR 36
  • 59.28 (n)
  • 55.98 (a)
PRLHR 37
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRLHR 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prlhr 36
  • 60.84 (n)
  • 57.83 (a)
zebrafish
(Danio rerio)
Actinopterygii prlhr2a 37
  • 50 (a)
OneToMany
prlhr2b 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sNPF-R 36
  • 55.86 (n)
  • 40.93 (a)
sNPF-R 37
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-6 37
  • 25 (a)
OneToOne
Species with no ortholog for PRLHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRLHR Gene

ENSEMBL:
Gene Tree for PRLHR (if available)
TreeFam:
Gene Tree for PRLHR (if available)

Paralogs for PRLHR Gene

Selected SIMAP similar genes for PRLHR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRLHR: view

Variants for PRLHR Gene

Sequence variations from dbSNP and Humsavar for PRLHR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs938700 -- 118,594,960(+) AAGTT(C/T)GTCAC synonymous-codon, reference
rs938701 -- 118,595,438(+) GAACA(C/T)ACGGT intron-variant
rs938702 -- 118,595,763(+) CATGC(C/T)TGGTG upstream-variant-2KB
rs938703 -- 118,595,764(+) ATGCC(C/T)GGTGC upstream-variant-2KB
rs938704 -- 118,595,789(+) AAGAG(C/G)ACAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRLHR Gene

Variant ID Type Subtype PubMed ID
nsv832006 CNV Gain 17160897
nsv7569 CNV Insertion 18451855

Relevant External Links for PRLHR Gene

HapMap Linkage Disequilibrium report
PRLHR
Human Gene Mutation Database (HGMD)
PRLHR

Disorders for PRLHR Gene

(1) MalaCards Diseases for PRLHR Gene

Search for PRLHR Gene in MalaCards »

(2) Novoseek inferred disease relationships for PRLHR Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma 42.7 4
obesity 1.84 2

Relevant External Links for PRLHR

Genetic Association Database (GAD)
PRLHR
Human Genome Epidemiology (HuGE) Navigator
PRLHR
genes like me logo Genes that share disorders with PRLHR: view

No data available for UniProtKB/Swiss-Prot for PRLHR Gene

Publications for PRLHR Gene

  1. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S. … Fujino M. (Nature 1998) 3 4 23
  2. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin S.H.S. … Civelli O. (Mol. Pharmacol. 2001) 3 4 23
  3. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PMID: 11923475) Ozawa A. … Mori M. (Mol. Endocrinol. 2002) 3 4 23
  4. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (PMID: 12716769) Bhattacharyya S. … O'Rahilly S. (Diabetes 2003) 3 23 49
  5. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PMID: 15885496) LagerstrAPm M.C. … SchiAPth H.B. (Genomics 2005) 2 3 23

Products for PRLHR Gene

Sources for PRLHR Gene

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