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Aliases for PRLHR Gene

Aliases for PRLHR Gene

  • Prolactin Releasing Hormone Receptor 2 3
  • G Protein-Coupled Receptor 10 2 3
  • G-Protein Coupled Receptor 10 3 4
  • PrRP Receptor 3 4
  • GPR10 3 4
  • PrRPR 3 4
  • HGR3 3 4
  • GR3 3 4
  • Prolactin Releasing Peptide Receptor 3
  • Prolactin-Releasing Hormone Receptor 3

External Ids for PRLHR Gene

Previous HGNC Symbols for PRLHR Gene

  • GPR10

Previous GeneCards Identifiers for PRLHR Gene

  • GC10M120344
  • GC10M113981

Summaries for PRLHR Gene

Entrez Gene Summary for PRLHR Gene

  • PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRLHR Gene

PRLHR (Prolactin Releasing Hormone Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for PRLHR Gene

  • Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing

Gene Wiki entry for PRLHR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLHR Gene

Genomics for PRLHR Gene

Regulatory Elements for PRLHR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRLHR Gene

Chromosome:
10
Start:
118,589,989 bp from pter
End:
118,599,895 bp from pter
Size:
9,907 bases
Orientation:
Minus strand

Genomic View for PRLHR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PRLHR Gene

Proteins for PRLHR Gene

  • Protein details for PRLHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49683-PRLHR_HUMAN
    Recommended name:
    Prolactin-releasing peptide receptor
    Protein Accession:
    P49683
    Secondary Accessions:
    • O75194
    • Q502U8
    • Q5VXR9

    Protein attributes for PRLHR Gene

    Size:
    370 amino acids
    Molecular mass:
    41121 Da
    Quaternary structure:
    • Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
    SequenceCaution:
    • Sequence=AAC50504.1; Type=Frameshift; Positions=168, 175; Evidence={ECO:0000305};

neXtProt entry for PRLHR Gene

Proteomics data for PRLHR Gene at MOPED

Post-translational modifications for PRLHR Gene

  • Glycosylation at Asn 27 and Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for PRLHR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PRLHR Gene

Domains & Families for PRLHR Gene

Gene Families for PRLHR Gene

Suggested Antigen Peptide Sequences for PRLHR Gene

Graphical View of Domain Structure for InterPro Entry

P49683

UniProtKB/Swiss-Prot:

PRLHR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PRLHR: view

Function for PRLHR Gene

Molecular function for PRLHR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing
UniProtKB/Swiss-Prot Induction:
Repressed by bromocriptine, a dopamine agonist.

Gene Ontology (GO) - Molecular Function for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8666380
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 11641419
GO:0008188 neuropeptide receptor activity TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view
genes like me logo Genes that share phenotypes with PRLHR: view

Animal Models for PRLHR Gene

MGI Knock Outs for PRLHR:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRLHR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PRLHR Gene

Localization for PRLHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRLHR Gene COMPARTMENTS Subcellular localization image for PRLHR gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8666380
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with PRLHR: view

Pathways & Interactions for PRLHR Gene

genes like me logo Genes that share pathways with PRLHR: view

Pathways by source for PRLHR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8666380
GO:0007218 neuropeptide signaling pathway TAS 9607765
GO:0007565 female pregnancy TAS 9607765
GO:0007631 feeding behavior IBA --
genes like me logo Genes that share ontologies with PRLHR: view

No data available for SIGNOR curated interactions for PRLHR Gene

Drugs & Compounds for PRLHR Gene

(8) Drugs for PRLHR Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]PrRP-20 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]PrRP31 Pharma 0
neuropeptide Y Pharma Full agonist, Agonist 0
NPY-(18-36) (human, pig) Pharma Full agonist, Agonist 0
PrRP-(24-31) (human) Pharma Full agonist, Agonist 0

(1) Additional Compounds for PRLHR Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
genes like me logo Genes that share compounds with PRLHR: view

Transcripts for PRLHR Gene

mRNA/cDNA for PRLHR Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRLHR Gene

Prolactin releasing hormone receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRLHR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLHR Gene

No ASD Table

Relevant External Links for PRLHR Gene

GeneLoc Exon Structure for
PRLHR
ECgene alternative splicing isoforms for
PRLHR

Expression for PRLHR Gene

mRNA expression in normal human tissues for PRLHR Gene

mRNA differential expression in normal tissues according to GTEx for PRLHR Gene

This gene is overexpressed in Pituitary (x15.6), Vagina (x6.7), Uterus (x5.2), and Brain - Hypothalamus (x4.3).

SOURCE GeneReport for Unigene cluster for PRLHR Gene Hs.248119

mRNA Expression by UniProt/SwissProt for PRLHR Gene

P49683-PRLHR_HUMAN
Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas.
genes like me logo Genes that share expression patterns with PRLHR: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRLHR Gene

Orthologs for PRLHR Gene

This gene was present in the common ancestor of animals.

Orthologs for PRLHR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRLHR 35
  • 90.27 (n)
  • 91.89 (a)
PRLHR 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRLHR 35
  • 91.62 (n)
  • 94.86 (a)
PRLHR 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prlhr 35
  • 86.19 (n)
  • 90.74 (a)
Prlhr 16
Prlhr 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRLHR 35
  • 99.55 (n)
  • 99.46 (a)
PRLHR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prlhr 35
  • 86.45 (n)
  • 91.21 (a)
oppossum
(Monodelphis domestica)
Mammalia PRLHR 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PRLHR 35
  • 59.28 (n)
  • 55.98 (a)
-- 36
  • 55 (a)
OneToMany
PRLHR 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRLHR 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prlhr 35
  • 60.84 (n)
  • 57.83 (a)
zebrafish
(Danio rerio)
Actinopterygii prlhr2a 36
  • 50 (a)
OneToMany
prlhr2b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sNPF-R 35
  • 55.86 (n)
  • 40.93 (a)
sNPF-R 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-6 36
  • 25 (a)
OneToOne
Species with no ortholog for PRLHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRLHR Gene

ENSEMBL:
Gene Tree for PRLHR (if available)
TreeFam:
Gene Tree for PRLHR (if available)

Paralogs for PRLHR Gene

genes like me logo Genes that share paralogs with PRLHR: view

Variants for PRLHR Gene

Sequence variations from dbSNP and Humsavar for PRLHR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs938700 -- 118,594,960(+) AAGTT(C/T)GTCAC synonymous-codon, reference
rs938701 -- 118,595,438(+) GAACA(C/T)ACGGT intron-variant
rs938702 -- 118,595,763(+) CATGC(C/T)TGGTG upstream-variant-2KB, intron-variant
rs938703 -- 118,595,764(+) ATGCC(C/T)GGTGC upstream-variant-2KB, intron-variant
rs938704 -- 118,595,789(+) AAGAG(C/G)ACAGT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRLHR Gene

Variant ID Type Subtype PubMed ID
nsv832006 CNV Gain 17160897
nsv7569 CNV Insertion 18451855

Variation tolerance for PRLHR Gene

Residual Variation Intolerance Score: 51.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRLHR Gene

HapMap Linkage Disequilibrium report
PRLHR
Human Gene Mutation Database (HGMD)
PRLHR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLHR Gene

Disorders for PRLHR Gene

Relevant External Links for PRLHR

Genetic Association Database (GAD)
PRLHR
Human Genome Epidemiology (HuGE) Navigator
PRLHR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRLHR
genes like me logo Genes that share disorders with PRLHR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLHR Gene

Publications for PRLHR Gene

  1. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PMID: 15885496) LagerstrAPm M.C. … SchiAPth H.B. (Genomics 2005) 2 23 67
  2. PDZ domain protein-protein interactions: a case study with PICK1. (PMID: 17266593) Dev K.K. (Curr Top Med Chem 2007) 23 67
  3. Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor. (PMID: 15752583) Ellacott K.L. … Luckman S.M. (Peptides 2005) 23 67
  4. The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. (PMID: 14742914) Gu W. … Stricker-Krongrad A. (J. Mol. Neurosci. 2004) 23 67
  5. Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. (PMID: 14691196) Franks P.W. … Wareham N.J. (Hypertension 2004) 23 67

Products for PRLHR Gene

Sources for PRLHR Gene

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