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PRLHR Gene

protein-coding   GIFtS: 58
GCID: GC10M120344

Prolactin Releasing Hormone Receptor

(Previous name: G protein-coupled receptor 10)
(Previous symbol: GPR10)
  See PRLHR-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prolactin Releasing Hormone Receptor1 2     G-Protein Coupled Receptor 102 3
GPR101 2 3 5     hGR32 3
G Protein-Coupled Receptor 101 2     Prolactin Releasing Peptide Receptor2
PrRP Receptor2 3     Prolactin-Releasing Hormone Receptor2
GR32 3     Prolactin-Releasing Peptide Receptor2
PrRPR2 3     

External Ids:    HGNC: 44641   Entrez Gene: 28342   Ensembl: ENSG000001199737   OMIM: 6008955   UniProtKB: P496833   

Export aliases for PRLHR gene to outside databases

Previous GC identifer: GC10M113981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRLHR Gene:
PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly
expressed in anterior pituitary (Ozawa et al., 2002 (PubMed 11923475)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PRLHR Gene:
PRLHR (prolactin releasing hormone receptor) is a protein-coding gene. Diseases associated with PRLHR include uterine fibroid. GO annotations related to this gene include neuropeptide Y receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: PRLHR_HUMAN, P49683
Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and
pain-signal processing

Gene Wiki entry for PRLHR (Prolactin-releasing peptide receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRLHR gene promoter:
         FOXF2   Pax-5   NRSF form 1   AP-2gamma   NRSF form 2   CREB   FOXC1   HFH-1   deltaCREB   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRLHR promoter sequence
   Search Chromatin IP Primers for PRLHR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRLHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q25.3-q26

PRLHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRLHR gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M120344:  view genomic region     (about GC identifiers)

Start:
120,352,916 bp from pter      End:
120,355,160 bp from pter
Size:
2,245 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRLHR_HUMAN, P49683 (See protein sequence)
Recommended Name: Prolactin-releasing peptide receptor  
Size: 370 amino acids; 41121 Da
Subunit: Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1.
Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1
Sequence caution: Sequence=AAC50504.1; Type=Frameshift; Positions=168, 175;
Secondary accessions: O75194 Q502U8 Q5VXR9

Explore the universe of human proteins at neXtProt for PRLHR: NX_P49683

Explore proteomics data for PRLHR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn27, Asn36
  • Modification sites at PhosphoSitePlus

  • See PRLHR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004239.1  
    ENSEMBL proteins: 
     ENSP00000358167   ENSP00000239032  
    Reactome Protein details: P49683

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PRLHR (3 products) 

     
    antibodies-online peptides for PRLHR

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RFAPR: GPCR / Class A : RF amide peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRRP receptor
    Prolactin-releasing peptide receptor

    3 InterPro protein domains:
     IPR001402 Prolrel_pep_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P49683

    ProtoNet protein and cluster: P49683

    1 Blocks protein domain: IPB001402 Probable G protein-coupled receptor GPR10 signature

    UniProtKB/Swiss-Prot: PRLHR_HUMAN, P49683
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with PRLHR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRLHR_HUMAN, P49683
    Function: Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and
    pain-signal processing
    Induction: Repressed by bromocriptine, a dopamine agonist

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8666380
    GO:0004983neuropeptide Y receptor activity IEA--
    GO:0005515protein binding IPI11641419
    GO:0008188neuropeptide receptor activity TAS9607765
         
    Find genes that share ontologies with PRLHR           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prlhr):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  integument 

    Find genes that share phenotypes with PRLHR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRLHR: Prlhrtm1Dgen Prlhrtm1Map

       genOway: Develop your customized and physiologically relevant rodent model for PRLHR

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    hsa-miR-877* hsa-miR-642a hsa-miR-1207-3p hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidPRLHR 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRLHR_HUMAN, P49683: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8666380
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with PRLHR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRLHR About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with PRLHR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PRLHR
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for PRLHR
        Peptide ligand-binding receptors


    1 Kegg Pathway  (Kegg details for PRLHR):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRLHR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRLHR

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for PRLHR (P496831, 2, 3 ENSP000002390324) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIP2Q9C0E42, 3MINT-1785769 I2D: score=1 
    GRIP1Q9Y3R01, 2, 3, ENSP000003810984EBI-8009236,EBI-5349621 MINT-1785743 MINT-1785849 I2D: score=2 STRING: ENSP00000381098
    PICK1Q9NRD52, 3, ENSP000003494654MINT-1785875 MINT-1785826 I2D: score=3 STRING: ENSP00000349465
    PRLHP812773, ENSP000001655244I2D: score=1 STRING: ENSP00000165524
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8666380
    GO:0007218neuropeptide signaling pathway TAS9607765
    GO:0007565female pregnancy TAS9607765
    GO:0007631feeding behavior IEA--
    GO:0042445hormone metabolic process IEA--

    Find genes that share ontologies with PRLHR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRLHR

    10 IUPHAR Ligands for PRLHR (PRRP receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]PrRP-20 (human)
    AgonistFull agonist9.2 - 10.611030716
    PrRP-20
    AgonistFull agonist9.711030716
    PrRP-20
    AgonistFull agonist9 - 9.611030716 12606605
    PrRP-31
    AgonistFull agonist9.511030716
    PrRP-31
    AgonistFull agonist9 - 9.211030716 12606605
    PrRP-(24-31) (human)
    AgonistFull agonist7.312606605
    neuropeptide Y
    AntagonistAntagonist5.415885496
    NPY-(18-36) (human, pig)
    AgonistPartial agonist5.112606605
    [125I]PrRP31
    NoneNone5.115752583
    PTHrP
    AgonistFull agonist5.1--

    1 Novoseek inferred chemical compound relationship for PRLHR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 5.8 1 11641419 (1)



    Find genes that share compounds with PRLHR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRLHR gene: 
    NM_004248.2  

    Unigene Cluster for PRLHR:

    Prolactin releasing hormone receptor
    Hs.248119  [show with all ESTs]
    Unigene Representative Sequence: NM_004248
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369169(uc021pzm.1) ENST00000239032(uc001ldp.1)
    miRNA
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    hsa-miR-877* hsa-miR-642a hsa-miR-1207-3p hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidPRLHR 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB015745.1 AK290461.1 AK313269.1 BC095539.1 BC101490.1 BC101492.1 EF577402.1 

    2 DOTS entries:

    DT.121243221  DT.102820834 

    12 AceView cDNA sequences:

    AB015745 CR607650 NM_004248 CN838171 AL528009 CN842565 CN839277 BX471829 
    CN839221 CN838339 AL563031 CN842623 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRLHR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTGCTTA
    PRLHR Expression
    About this image

    PRLHR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRLHR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248119

    UniProtKB/Swiss-Prot: PRLHR_HUMAN, P49683
    Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRLHR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRLHR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prlhr1 , 5 prolactin releasing hormone receptor1, 5 86.19(n)1
    90.74(a)1
      19 (56.52 cM)5
    2262781  NM_201615.21  NP_963909.21 
     604667335 
    chicken
    (Gallus gallus)
    Aves PRLHR1 prolactin releasing hormone receptor 59.28(n)
    55.98(a)
      428985  NM_001012295.2  NP_001012295.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRLHR6
    prolactin releasing hormone receptor
    66(a)
    1 ↔ 1
    GL343206.1(80785-82599)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ524111.12   -- 79.66(n)    BQ524111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prlhr2b6
    prlhr2a6
    prolactin releasing hormone receptor 2a
    53(a)
    50(a)
    many → 1
    many → 1
    10(42627246-42635288) ENSDARG00000036458
    8(39017817-39061266) ENSDARG00000044900
    fruit fly
    (Drosophila melanogaster)
    Insecta sNPF-R1 short neuropeptide F receptor 55.86(n)
    40.93(a)
      40195  NM_001275157.1  NP_001262086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npr-66
    Protein NPR-6 (npr-6) mRNA, complete cds
    25(a)
    1 ↔ 1
    X(10282825-10285734) WBGene00009619


    ENSEMBL Gene Tree for PRLHR (if available)
    TreeFam Gene Tree for PRLHR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRLHR gene
    GPR832  HCRTR22  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    Selected SIMAP similar genes for PRLHR using alignment to 2 protein entries:     PRLHR_HUMAN (see all proteins) (see all similar genes):
    NPY1R    NPY2R    GALR1    GPR83    NPFFR2    PPYR1
    NPY4R    PROKR2    BRS3    SSTR1    SSTR4    TACR1
    TACR3    NPY6R    OPRL1    KISS1R    PROKR1    TACR2

    Find genes that share paralogs with PRLHR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRLHR (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922858701,2
    --120708525(+) GTTAAA/GGTGAT 1 -- ds50010--------
    rs22259161,2
    H--120708581(-) CTCCAG/CGGTTA 1 -- ds50014Minor allele frequency- C:0.00NS EA 396
    rs1382694441,2
    --120708586(+) CTGGAC/GGTAAT 1 -- ds50010--------
    rs1496409921,2
    --120708641(+) GTTCTA/GTCCTT 1 -- ds50010--------
    rs1468930071,2
    --120708648(+) CCTTAA/GGTAAA 1 -- ds50010--------
    rs1390532391,2
    --120708755(+) GTGAGC/TAATTA 1 -- ds50010--------
    rs1839072181,2
    --120708781(+) TGCCAC/TGCTAC 1 -- ds50010--------
    rs70978081,2
    C,F--120708884(+) caaacA/Tcacat 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs608009251,2
    C,F--120708933(+) CTCTTA/CAGTGA 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1429654241,2
    C--120709066(+) AGGTGC/TTTTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRLHR (120352916 - 120355160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRLHR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7569CNV Insertion18451855
    nsv832006CNV Gain17160897

    Human Gene Mutation Database (HGMD): PRLHR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRLHR
    DNA2.0 Custom Variant and Variant Library Synthesis for PRLHR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600895    OMIM disorders: --

    1 disease for PRLHR:    
    About MalaCards
    uterine fibroid


    Find genes that share disorders with PRLHR           About GenesLikeMe

    2 Novoseek inferred disease relationships for PRLHR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 42.7 4 10984631 (3), 11923475 (1)
    obesity 1.84 3 12716769 (2)

    Genetic Association Database (GAD): PRLHR
    Human Genome Epidemiology (HuGE) Navigator: PRLHR (5 documents)

    Export disorders for PRLHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PRLHR gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with PRLHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 2, 3 Marchese A.... Docherty J.M. (Genomics 1995)
    2. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (PubMed id 12716769)1, 4, 9 Bhattacharyya S....O'Rahilly S. (Diabetes 2003)
    3. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PubMed id 11641419)1, 2, 9 Lin S.H.S.... Civelli O. (Mol. Pharmacol. 2001)
    4. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PubMed id 15885496)1, 3, 9 LagerstrAPm M.C....SchiAPth H.B. (Genomics 2005)
    5. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PubMed id 11923475)1, 2, 9 Ozawa A.... Mori M. (Mol. Endocrinol. 2002)
    6. A prolactin-releasing peptide in the brain. (PubMed id 9607765)1, 2, 9 Hinuma S.... Fujino M. (Nature 1998)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. (PubMed id 10498338)1, 2 Fujii R.... Fujino M. (Regul. Pept. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2834 HGNC: 4464 AceView: GPR10 Ensembl:ENSG00000119973 euGenes: HUgn2834
    ECgene: PRLHR Kegg: 2834 H-InvDB: PRLHR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRLHR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRLHR gene:
    Search GeneIP for patents involving PRLHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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