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Aliases for PRLHR Gene

Aliases for PRLHR Gene

  • Prolactin Releasing Hormone Receptor 2 3 5
  • G-Protein Coupled Receptor 10 3 4
  • PrRP Receptor 3 4
  • GPR10 3 4
  • PrRPR 3 4
  • HGR3 3 4
  • GR3 3 4
  • Prolactin-Releasing Peptide Receptor 3
  • G Protein-Coupled Receptor 10 2

External Ids for PRLHR Gene

Previous HGNC Symbols for PRLHR Gene

  • GPR10

Previous GeneCards Identifiers for PRLHR Gene

  • GC10M120344
  • GC10M113981

Summaries for PRLHR Gene

Entrez Gene Summary for PRLHR Gene

  • PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRLHR Gene

PRLHR (Prolactin Releasing Hormone Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot for PRLHR Gene

  • Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.

Gene Wiki entry for PRLHR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLHR Gene

Genomics for PRLHR Gene

Regulatory Elements for PRLHR Gene

Enhancers for PRLHR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G118729 1.1 Ensembl ENCODE 10.7 -131.4 -131424 4.6 JUN WRNIP1 FEZF1 ZBTB40 ZNF766 GATA3 ARID3A ETV6 IKZF2 ZNF263 CACUL1 PRLHR GC10P118694
GH10G118725 1.1 Ensembl ENCODE 10.7 -126.4 -126387 0.9 INSM2 FEZF1 ZNF2 ZNF366 ZSCAN5C ZNF391 OVOL3 TSHZ1 ZEB2 ZNF398 CACUL1 PRLHR GC10P118694
GH10G118568 0.9 Ensembl ENCODE 11.9 +31.3 31334 0.5 CTCF ZNF654 ZNF362 PKNOX1 ARNT MTA2 MNT ZNF384 REST RAD21 PRLHR SLC25A18P1 GC10P118535 GC10P118534
GH10G118571 0.4 ENCODE 18.7 +28.6 28620 0.6 RAD21 PRLHR SLC25A18P1 GC10P118535 GC10P118534
GH10G118797 0.6 ENCODE 11.1 -198.7 -198659 1.2 ESRRA ZNF362 RFX1 ZFP37 FOS PRDM1 PRLHR GC10M118785 PIR53333
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRLHR on UCSC Golden Path with GeneCards custom track

Genomic Location for PRLHR Gene

Chromosome:
10
Start:
118,589,989 bp from pter
End:
118,599,895 bp from pter
Size:
9,907 bases
Orientation:
Minus strand

Genomic View for PRLHR Gene

Genes around PRLHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLHR Gene

Proteins for PRLHR Gene

  • Protein details for PRLHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49683-PRLHR_HUMAN
    Recommended name:
    Prolactin-releasing peptide receptor
    Protein Accession:
    P49683
    Secondary Accessions:
    • O75194
    • Q502U8
    • Q5VXR9

    Protein attributes for PRLHR Gene

    Size:
    370 amino acids
    Molecular mass:
    41121 Da
    Quaternary structure:
    • Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
    SequenceCaution:
    • Sequence=AAC50504.1; Type=Frameshift; Positions=168, 175; Evidence={ECO:0000305};

neXtProt entry for PRLHR Gene

Post-translational modifications for PRLHR Gene

  • Glycosylation at isoforms=27 and isoforms=36
  • Modification sites at PhosphoSitePlus

Other Protein References for PRLHR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLHR Gene

Domains & Families for PRLHR Gene

Gene Families for PRLHR Gene

Suggested Antigen Peptide Sequences for PRLHR Gene

Graphical View of Domain Structure for InterPro Entry

P49683

UniProtKB/Swiss-Prot:

PRLHR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PRLHR: view

Function for PRLHR Gene

Molecular function for PRLHR Gene

UniProtKB/Swiss-Prot Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
UniProtKB/Swiss-Prot Induction:
Repressed by bromocriptine, a dopamine agonist.

Gene Ontology (GO) - Molecular Function for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8666380
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0005515 protein binding IPI 11641419
GO:0008188 neuropeptide receptor activity TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view
genes like me logo Genes that share phenotypes with PRLHR: view

Animal Models for PRLHR Gene

MGI Knock Outs for PRLHR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRLHR

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRLHR Gene

Localization for PRLHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLHR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8666380
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRLHR: view

Pathways & Interactions for PRLHR Gene

genes like me logo Genes that share pathways with PRLHR: view

Pathways by source for PRLHR Gene

Gene Ontology (GO) - Biological Process for PRLHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8666380
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007565 female pregnancy TAS 9607765
genes like me logo Genes that share ontologies with PRLHR: view

No data available for SIGNOR curated interactions for PRLHR Gene

Drugs & Compounds for PRLHR Gene

(8) Drugs for PRLHR Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]PrRP-20 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]PrRP31 Pharma 0
neuropeptide Y Pharma Full agonist, Agonist 0
NPY-(18-36) (human, pig) Pharma Full agonist, Agonist 0
PrRP-(24-31) (human) Pharma Full agonist, Agonist 0

(1) Additional Compounds for PRLHR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLHR: view

Transcripts for PRLHR Gene

mRNA/cDNA for PRLHR Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRLHR Gene

Prolactin releasing hormone receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLHR Gene

No ASD Table

Relevant External Links for PRLHR Gene

GeneLoc Exon Structure for
PRLHR
ECgene alternative splicing isoforms for
PRLHR

Expression for PRLHR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRLHR Gene

mRNA differential expression in normal tissues according to GTEx for PRLHR Gene

This gene is overexpressed in Pituitary (x15.6), Vagina (x6.7), Uterus (x5.2), and Brain - Hypothalamus (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PRLHR Gene:

PRLHR

SOURCE GeneReport for Unigene cluster for PRLHR Gene:

Hs.248119

mRNA Expression by UniProt/SwissProt for PRLHR Gene:

P49683-PRLHR_HUMAN
Tissue specificity: Only detected in the pituitary gland and in all cell types of pituitary adenomas.
genes like me logo Genes that share expression patterns with PRLHR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLHR Gene

Orthologs for PRLHR Gene

This gene was present in the common ancestor of animals.

Orthologs for PRLHR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRLHR 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia PRLHR 34 35
  • 91.62 (n)
cow
(Bos Taurus)
Mammalia PRLHR 34 35
  • 90.27 (n)
rat
(Rattus norvegicus)
Mammalia Prlhr 34
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Prlhr 34 16 35
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia PRLHR 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PRLHR 34 35
  • 59.28 (n)
-- 35
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRLHR 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prlhr 34
  • 60.84 (n)
zebrafish
(Danio rerio)
Actinopterygii prlhr2b 35
  • 53 (a)
OneToMany
prlhr2a 35
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sNPF-R 34 35
  • 55.86 (n)
worm
(Caenorhabditis elegans)
Secernentea npr-6 35
  • 25 (a)
OneToOne
Species where no ortholog for PRLHR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRLHR Gene

ENSEMBL:
Gene Tree for PRLHR (if available)
TreeFam:
Gene Tree for PRLHR (if available)

Paralogs for PRLHR Gene

genes like me logo Genes that share paralogs with PRLHR: view

Variants for PRLHR Gene

Sequence variations from dbSNP and Humsavar for PRLHR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001296871 -- 118,594,521(+) CAGGA(A/G)GATGA reference, missense
rs1001667502 -- 118,594,303(+) CCAGC(-/CCAAAGG)CCAAA reference, frameshift-variant
rs1003657331 -- 118,596,007(+) AGGAA(G/T)TAGCG upstream-variant-2KB
rs1004043948 -- 118,593,119(+) TCTGC(C/T)GGTCC downstream-variant-500B
rs1005602571 -- 118,595,519(+) ACCTG(C/G)GAGTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRLHR Gene

Variant ID Type Subtype PubMed ID
nsv7569 CNV insertion 18451855
nsv832006 CNV gain 17160897
nsv951861 CNV deletion 24416366

Variation tolerance for PRLHR Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRLHR Gene

Human Gene Mutation Database (HGMD)
PRLHR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRLHR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLHR Gene

Disorders for PRLHR Gene

Relevant External Links for PRLHR

Genetic Association Database (GAD)
PRLHR
Human Genome Epidemiology (HuGE) Navigator
PRLHR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRLHR

No disorders were found for PRLHR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLHR Gene

Publications for PRLHR Gene

  1. Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. (PMID: 15885496) LagerstrAPm M.C. … SchiAPth H.B. (Genomics 2005) 2 3 22 64
  2. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. (PMID: 12716769) Bhattacharyya S. … O'Rahilly S. (Diabetes 2003) 3 22 46 64
  3. Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. (PMID: 11923475) Ozawa A. … Mori M. (Mol. Endocrinol. 2002) 3 4 22 64
  4. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin S.H.S. … Civelli O. (Mol. Pharmacol. 2001) 3 4 22 64
  5. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S. … Fujino M. (Nature 1998) 3 4 22 64

Products for PRLHR Gene

Sources for PRLHR Gene

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