Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRLH Gene

Aliases for PRLH Gene

  • Prolactin Releasing Hormone 2 3 5
  • PRRP 3 4
  • PRH 3 4
  • Preproprolactin-Releasing Peptide 3
  • Prolactin-Releasing Peptide 3
  • Prolactin-Releasing Hormone 4

External Ids for PRLH Gene

Previous GeneCards Identifiers for PRLH Gene

  • GC02P238762
  • GC02P238257
  • GC02P238139
  • GC02P238475
  • GC02P230265

Summaries for PRLH Gene

GeneCards Summary for PRLH Gene

PRLH (Prolactin Releasing Hormone) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and prolactin-releasing peptide receptor binding.

UniProtKB/Swiss-Prot for PRLH Gene

  • Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Gene Wiki entry for PRLH Gene

Additional gene information for PRLH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLH Gene

Genomics for PRLH Gene

GeneHancer (GH) Regulatory Elements for PRLH Gene

Promoters and enhancers for PRLH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I237685 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +125.8 125810 13.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 LRRFIP1 ILKAP RAB17 LOC105373958 PRLH RNU6-1140P RBM44 ESPNL UBE2F PIR56300
GH02I237588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 12.1 +25.5 25512 7.8 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 RAB17 LOC105373958 PRLH RNU6-1140P MLPH RAMP1 TRAF3IP1
GH02I237508 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -55.3 -55338 5.4 FOXA2 ARID4B NEUROD1 SIN3A ZNF2 ZNF48 ZNF143 RXRA MIER2 REST MIR6811 MLPH RNU6-1140P PRLH LOC105373958 RAB17 ENSG00000222022 COL6A3
GH02I237473 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -91.7 -91673 3.8 ATF1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 FOS KLF13 SP3 MLPH ENSG00000222022 COL6A3 RNU6-1140P PRLH LRRFIP1 ENSG00000222032
GH02I237464 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -100.9 -100871 2.7 HDAC1 ATF1 NFRKB ZBTB40 RCOR1 FOS ATF7 CREM ZBTB11 NCOA1 COL6A3 MLPH ENSG00000222022 RAB17 RNU6-1140P PRLH ENSG00000222032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRLH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRLH gene promoter:

Genomic Locations for PRLH Gene

Genomic Locations for PRLH Gene
602 bases
Plus strand

Genomic View for PRLH Gene

Genes around PRLH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLH Gene

Proteins for PRLH Gene

  • Protein details for PRLH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prolactin-releasing peptide
    Protein Accession:

    Protein attributes for PRLH Gene

    87 amino acids
    Molecular mass:
    9639 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRLH Gene

Post-translational modifications for PRLH Gene

No Post-translational modifications

Other Protein References for PRLH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLH Gene

Domains & Families for PRLH Gene

Gene Families for PRLH Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRLH Gene


Suggested Antigen Peptide Sequences for PRLH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRLH: view

No data available for UniProtKB/Swiss-Prot for PRLH Gene

Function for PRLH Gene

Molecular function for PRLH Gene

UniProtKB/Swiss-Prot Function:
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Phenotypes From GWAS Catalog for PRLH Gene

Gene Ontology (GO) - Molecular Function for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 9607765
GO:0005184 neuropeptide hormone activity IEA --
GO:0031861 prolactin-releasing peptide receptor binding IEA --
genes like me logo Genes that share ontologies with PRLH: view
genes like me logo Genes that share phenotypes with PRLH: view

Animal Models for PRLH Gene

MGI Knock Outs for PRLH:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRLH Gene

Localization for PRLH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLH Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLH gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
plasma membrane 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PRLH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRLH Gene

Pathways & Interactions for PRLH Gene

genes like me logo Genes that share pathways with PRLH: view

Interacting Proteins for PRLH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P81277-PRRP_HUMAN ENSP00000165524 for PRLH Gene via IID STRING

Gene Ontology (GO) - Biological Process for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IEA --
GO:0002021 response to dietary excess IEA --
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006112 energy reserve metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PRLH: view

No data available for SIGNOR curated interactions for PRLH Gene

Drugs & Compounds for PRLH Gene

(5) Drugs for PRLH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PRLH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLH: view

Transcripts for PRLH Gene

mRNA/cDNA for PRLH Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLH Gene

No ASD Table

Relevant External Links for PRLH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRLH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRLH Gene

mRNA differential expression in normal tissues according to GTEx for PRLH Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x33.9) and Heart - Atrial Appendage (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of PRLH Gene:


SOURCE GeneReport for Unigene cluster for PRLH Gene:


mRNA Expression by UniProt/SwissProt for PRLH Gene:

Tissue specificity: Medulla oblongata and hypothalamus.

Evidence on tissue expression from TISSUES for PRLH Gene

  • Nervous system(4.5)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with PRLH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLH Gene

Orthologs for PRLH Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRLH Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Prlh 33 16 34
  • 79.67 (n)
(Rattus norvegicus)
Mammalia Prlh 33
  • 74.9 (n)
(Canis familiaris)
Mammalia PRLH 34
  • 67 (a)
(Bos Taurus)
Mammalia PRLH 34
  • 66 (a)
(Anolis carolinensis)
Reptilia PRLH 34
  • 53 (a)
Species where no ortholog for PRLH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRLH Gene

Gene Tree for PRLH (if available)
Gene Tree for PRLH (if available)

Paralogs for PRLH Gene

(1) SIMAP similar genes for PRLH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRLH: view

No data available for Paralogs for PRLH Gene

Variants for PRLH Gene

Sequence variations from dbSNP and Humsavar for PRLH Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000121219 -- 237,565,200(+) A/G/T upstream_transcript_variant
rs1000182244 -- 237,565,170(+) C/T upstream_transcript_variant
rs1000567739 -- 237,565,835(+) C/A upstream_transcript_variant
rs1003428990 -- 237,566,240(+) C/A upstream_transcript_variant
rs1004459168 -- 237,565,601(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRLH Gene

Variant ID Type Subtype PubMed ID
dgv4192n100 CNV loss 25217958
nsv1000252 CNV loss 25217958
nsv1010093 CNV gain 25217958

Variation tolerance for PRLH Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRLH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLH Gene

Disorders for PRLH Gene

Additional Disease Information for PRLH

No disorders were found for PRLH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLH Gene

Publications for PRLH Gene

  1. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S … Fujino M (Nature 1998) 2 3 4 22 58
  2. Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. (PMID: 10498338) Fujii R … Fujino M (Regulatory peptides 1999) 3 4 22 58
  3. The ancestry of the prolactin-releasing hormone precursor. (PMID: 15891064) Lagerström MC … Schiöth HB (Annals of the New York Academy of Sciences 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of prolactin-releasing peptide in human placenta and decidua. (PMID: 11523913) Yasui Y … Murata Y (Endocrine journal 2001) 3 22 58

Products for PRLH Gene

Sources for PRLH Gene

Loading form....