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Aliases for PRLH Gene

Aliases for PRLH Gene

  • Prolactin Releasing Hormone 2 3 5
  • PRRP 3 4
  • PRH 3 4
  • Preproprolactin-Releasing Peptide 3
  • Prolactin-Releasing Peptide 3
  • Prolactin-Releasing Hormone 4

External Ids for PRLH Gene

Previous GeneCards Identifiers for PRLH Gene

  • GC02P238762
  • GC02P238257
  • GC02P238139
  • GC02P238475
  • GC02P230265

Summaries for PRLH Gene

GeneCards Summary for PRLH Gene

PRLH (Prolactin Releasing Hormone) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include hormone activity and prolactin-releasing peptide receptor binding.

UniProtKB/Swiss-Prot for PRLH Gene

  • Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Gene Wiki entry for PRLH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRLH Gene

Genomics for PRLH Gene

Regulatory Elements for PRLH Gene

Enhancers for PRLH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G237508 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -55.3 -55339 5.4 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 KLF13 REST MLPH RNU6-1140P PRLH LOC105373958 RAB17 ENSG00000222022 COL6A3 MIR6811
GH02G237464 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -100.9 -100872 2.7 HDAC1 ATF1 NFRKB ELK1 GATA2 FOS CREM ZBTB11 JUNB CEBPB COL6A3 MLPH ENSG00000222022 RAB17 RNU6-1140P PRLH ENSG00000222032
GH02G237473 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -91.7 -91673 3.8 ATF1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 FOS SP3 SP5 MLPH ENSG00000222022 COL6A3 RNU6-1140P PRLH LRRFIP1 ENSG00000222032
GH02G237685 1.8 FANTOM5 ENCODE dbSUPER 10.2 +125.8 125810 13.1 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRFIP1 ILKAP RAB17 LOC105373958 PRLH RNU6-1140P RBM44 ESPNL UBE2F PIR56300
GH02G237588 1.5 Ensembl ENCODE dbSUPER 12.1 +25.5 25512 7.8 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ELK1 RAB17 PRLH RNU6-1140P MLPH LOC105373958 RAMP1 TRAF3IP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRLH on UCSC Golden Path with GeneCards custom track

Genomic Location for PRLH Gene

Chromosome:
2
Start:
237,566,574 bp from pter
End:
237,567,175 bp from pter
Size:
602 bases
Orientation:
Plus strand

Genomic View for PRLH Gene

Genes around PRLH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRLH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRLH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRLH Gene

Proteins for PRLH Gene

  • Protein details for PRLH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81277-PRRP_HUMAN
    Recommended name:
    Prolactin-releasing peptide
    Protein Accession:
    P81277

    Protein attributes for PRLH Gene

    Size:
    87 amino acids
    Molecular mass:
    9639 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRLH Gene

Post-translational modifications for PRLH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRLH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRLH Gene

Domains & Families for PRLH Gene

Gene Families for PRLH Gene

Protein Domains for PRLH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRLH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRLH: view

No data available for UniProtKB/Swiss-Prot for PRLH Gene

Function for PRLH Gene

Molecular function for PRLH Gene

UniProtKB/Swiss-Prot Function:
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Gene Ontology (GO) - Molecular Function for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 9607765
GO:0005184 neuropeptide hormone activity IEA --
GO:0031861 prolactin-releasing peptide receptor binding IEA --
genes like me logo Genes that share ontologies with PRLH: view
genes like me logo Genes that share phenotypes with PRLH: view

Animal Models for PRLH Gene

MGI Knock Outs for PRLH:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRLH Gene

Localization for PRLH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRLH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRLH gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
plasma membrane 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PRLH: view

Pathways & Interactions for PRLH Gene

genes like me logo Genes that share pathways with PRLH: view

Interacting Proteins for PRLH Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000165524%0d%0a9606.ENSP00000239032%0d%0a
Selected Interacting proteins: P81277-PRRP_HUMAN ENSP00000165524 for PRLH Gene via IID STRING

Gene Ontology (GO) - Biological Process for PRLH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IEA --
GO:0002021 response to dietary excess IEA --
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006112 energy reserve metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with PRLH: view

No data available for SIGNOR curated interactions for PRLH Gene

Drugs & Compounds for PRLH Gene

(5) Drugs for PRLH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PRLH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRLH: view

Transcripts for PRLH Gene

mRNA/cDNA for PRLH Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRLH Gene

No ASD Table

Relevant External Links for PRLH Gene

GeneLoc Exon Structure for
PRLH
ECgene alternative splicing isoforms for
PRLH

Expression for PRLH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRLH Gene

mRNA differential expression in normal tissues according to GTEx for PRLH Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x33.9) and Heart - Atrial Appendage (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of PRLH Gene:

PRLH

SOURCE GeneReport for Unigene cluster for PRLH Gene:

Hs.247710

mRNA Expression by UniProt/SwissProt for PRLH Gene:

P81277-PRRP_HUMAN
Tissue specificity: Medulla oblongata and hypothalamus.

Evidence on tissue expression from TISSUES for PRLH Gene

  • Nervous system(4.5)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with PRLH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRLH Gene

Orthologs for PRLH Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRLH Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Prlh 34 16 35
  • 79.67 (n)
rat
(Rattus norvegicus)
Mammalia Prlh 34
  • 74.9 (n)
dog
(Canis familiaris)
Mammalia PRLH 35
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRLH 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRLH 35
  • 53 (a)
OneToOne
Species where no ortholog for PRLH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRLH Gene

ENSEMBL:
Gene Tree for PRLH (if available)
TreeFam:
Gene Tree for PRLH (if available)

Paralogs for PRLH Gene

(1) SIMAP similar genes for PRLH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRLH: view

No data available for Paralogs for PRLH Gene

Variants for PRLH Gene

Sequence variations from dbSNP and Humsavar for PRLH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000121219 -- 237,565,200(+) ACCTC(A/T)TTGCG upstream-variant-2KB
rs1000182244 -- 237,565,170(+) GCTGA(C/T)GCGCA upstream-variant-2KB
rs1000567739 -- 237,565,835(+) CACAC(A/C)TACAC upstream-variant-2KB
rs1003428990 -- 237,566,240(+) ACATA(A/C)ACACA upstream-variant-2KB
rs1004459168 -- 237,565,601(+) CACAC(A/G)CACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRLH Gene

Variant ID Type Subtype PubMed ID
dgv4192n100 CNV loss 25217958
nsv1000252 CNV loss 25217958
nsv1010093 CNV gain 25217958

Variation tolerance for PRLH Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRLH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRLH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRLH Gene

Disorders for PRLH Gene

Relevant External Links for PRLH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRLH

No disorders were found for PRLH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRLH Gene

Publications for PRLH Gene

  1. A prolactin-releasing peptide in the brain. (PMID: 9607765) Hinuma S. … Fujino M. (Nature 1998) 2 3 4 22 64
  2. Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. (PMID: 10498338) Fujii R. … Fujino M. (Regul. Pept. 1999) 3 4 22 64
  3. The ancestry of the prolactin-releasing hormone precursor. (PMID: 15891064) LagerstrAPm M.C. … SchiAPth H.B. (Ann. N. Y. Acad. Sci. 2005) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Expression of prolactin-releasing peptide in human placenta and decidua. (PMID: 11523913) Yasui Y. … Murata Y. (Endocr. J. 2001) 3 22 64

Products for PRLH Gene

Sources for PRLH Gene

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