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PRL Gene

protein-coding   GIFtS: 66
GCID: GC06M022230

Prolactin

  See PRL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
prolactin1 2
Decidual Prolactin2

External Ids:    HGNC: 94451   Entrez Gene: 56172   Ensembl: ENSG000001721797   OMIM: 1767605   UniProtKB: P012363   

Export aliases for PRL gene to outside databases

Previous GC identifers: GC06M022345 GC06M022395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRL Gene:
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many
tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis,
and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the
same protein. (provided by RefSeq, Aug 2011)

GeneCards Summary for PRL Gene:
PRL (prolactin) is a protein-coding gene. Diseases associated with PRL include hypogonadotropism, and sheehan syndrome. GO annotations related to this gene include prolactin receptor binding and hormone activity.

UniProtKB/Swiss-Prot: PRL_HUMAN, P01236
Function: Prolactin acts primarily on the mammary gland by promoting lactation

Gene Wiki entry for PRL (Prolactin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRL gene promoter:
         AP-1   ATF-2   FOXO1a   STAT3   IRF-1   c-Jun   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRL promoter sequence
   Search Chromatin IP Primers for PRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

PRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M022230:  view genomic region     (about GC identifiers)

Start:
22,287,475 bp from pter      End:
22,303,082 bp from pter
Size:
15,608 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRL_HUMAN, P01236 (See protein sequence)
Recommended Name: Prolactin precursor  
Size: 227 amino acids; 25876 Da
Sequence caution: Sequence=CAA38264.1; Type=Frameshift; Positions=8;
Selected PDB 3D structures from and Proteopedia for PRL (see all 12):
1RW5 (3D)        2Q98 (3D)        3D48 (3D)        3EW3 (3D)        3MZG (3D)        3N06 (3D)    
Secondary accessions: Q15199 Q92996

Explore the universe of human proteins at neXtProt for PRL: NX_P01236

Explore proteomics data for PRL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59
  • Modification sites at PhosphoSitePlus

  • See PRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000939.1  NP_001157030.1  

    ENSEMBL proteins: 
     ENSP00000302150  
    Reactome Protein details: P01236

    PRL Human Recombinant Protein Products:

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    OriGene MassSpec for PRL
    OriGene Custom Protein Services for PRL
    GenScript Custom Purified and Recombinant Proteins Services for PRL
    Novus Biologicals PRL Proteins
    Novus Biologicals PRL Lysates
    Sino Biological Recombinant Protein for PRL
    Sino Biological Cell Lysate for PRL
    ProSpec Recombinant Protein for PRL
    Cloud-Clone Corp. Proteins for PRL

     
    Search eBioscience for Proteins for PRL 

     
    antibodies-online proteins for PRL (133 products) 

     
    antibodies-online peptides for PRL

    PRL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRL
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    Novus Biologicals PRL Antibodies
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    Cloud-Clone Corp. Antibodies for PRL
    ThermoFisher Antibody for PRL
    LSBio Antibodies in human, mouse, rat for PRL
    antibodies-online antibodies for PRL (310 products) 

    PRL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRL
    R&D Systems ELISAs for PRL (Prolactin)         (see first)
    R&D Systems Proteome Profiler Antibody Arrays for PRL (Prolactin)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for PRL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRL
    Cloud-Clone Corp. CLIAs for PRL
    Search eBioscience for ELISAs for PRL 
    antibodies-online kits for PRL (66 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR018116 Somatotropin_CS
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR001400 Somatotropin

    Graphical View of Domain Structure for InterPro Entry P01236

    ProtoNet protein and cluster: P01236

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: PRL_HUMAN, P01236
    Similarity: Belongs to the somatotropin/prolactin family


    Find genes that share domains with PRL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRL_HUMAN, P01236
    Function: Prolactin acts primarily on the mammary gland by promoting lactation

         Genatlas biochemistry entry for PRL:
    prolactin

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005148prolactin receptor binding TAS10854700
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with PRL           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prl):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  immune system  integument 
     liver/biliary system  nervous system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with PRL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prltm1Hmn for PRL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRL

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPRL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRL
    Predesigned siRNA for gene silencing in human, mouse, rat PRL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRL

    Clone
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    OriGene clones in human, mouse for PRL (see all 11)
    OriGene ORF clones in mouse, rat for PRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRL (NM_004248)
    Sino Biological Human cDNA Clone for PRL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PRL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRL_HUMAN, P01236: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    plasma membrane2
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0030141secretory granule ----

    Find genes that share ontologies with PRL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRL About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Prolactin Signaling Pathway0.39
    2Nuclear signaling by ERBB4
    Nuclear signaling by ERBB4
    Prolactin receptor signaling0.00
    3RNA Polymerase I Promoter Opening
    Amyloids0.68
    4PI-3K cascade
    Signaling by ERBB40.66
    5Interferon Signaling
    Cytokine Signaling in Immune system0.59


    Find genes that share SuperPaths with PRL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRL
        JAK-STAT Pathway
    Prolactin Signaling

    1 GeneGo (Thomson Reuters) Pathway for PRL
        Development Prolactin receptor signaling

    5 BioSystems Pathways for PRL
        Prostaglandin Synthesis and Regulation
    Prolactin Signaling Pathway
    ErbB4 signaling events
    Glucocorticoid receptor regulatory network
    Signaling events mediated by PTP1B


    3 Reactome Pathways for PRL
        Amyloids
    Growth hormone receptor signaling
    Prolactin receptor signaling


    5 Kegg Pathways  (Kegg details for PRL):
        Cytokine-cytokine receptor interaction
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRL: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRL (P012361, 3 ENSP000003021504) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPIBP232843, ENSP000003000264I2D: score=2 STRING: ENSP00000300026
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=1 STRING: ENSP00000357292
    PAK2Q131773I2D: score=1 
    PRLRP16471-71, ENSP000003714324EBI-6903064,EBI-6903057 I2D: score=2 STRING: ENSP00000371432
    APCSENSP000002550404STRING: ENSP00000255040
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS10854700
    GO:0007262STAT protein import into nucleus ----
    GO:0007565female pregnancy NAS7221563
    GO:0007567parturition ----
    GO:0007584response to nutrient ----

    Find genes that share ontologies with PRL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRL

    Selected Novoseek inferred chemical compound relationships for PRL gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromocriptine 93.1 682 17917811 (5), 11579944 (5), 1490255 (4), 1543025 (4) (see all 99)
    acth 89.4 1254 9876339 (6), 14533141 (6), 14604600 (6), 12475731 (5) (see all 99)
    cabergoline 88.6 223 10931080 (6), 10404830 (5), 11579944 (4), 12699451 (4) (see all 99)
    testosterone 88.4 1978 9334596 (7), 15670199 (6), 10639190 (5), 11966629 (5) (see all 99)
    quinagolide 87.3 71 7889620 (5), 8921822 (4), 10931080 (4), 18211974 (3) (see all 27)
    estradiol 87.1 1052 16775175 (6), 16557037 (6), 2209924 (5), 2162014 (5) (see all 99)
    fenfluramine 85.8 552 11959359 (7), 12680745 (7), 10760377 (6), 10674278 (6) (see all 99)
    progesterone 83.1 1127 9158065 (9), 14559722 (7), 2209924 (7), 19215357 (6) (see all 99)
    dehydroepiandrosterone sulfate 82.3 356 9159534 (7), 1832389 (5), 7586621 (4), 11499189 (4) (see all 99)
    dopamine 81.4 1015 7977731 (8), 8284103 (8), 8119166 (8), 1618163 (6) (see all 99)



    Find genes that share compounds with PRL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRL gene (2 alternative transcripts): 
    NM_000948.5  NM_001163558.2  

    Unigene Cluster for PRL:

    Prolactin
    Hs.1905  [show with all ESTs]
    Unigene Representative Sequence: CD242874
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306482(uc003ndo.3 uc003ndp.3 uc003ndq.3 uc003ndr.1)

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRL
    Clone
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    GenScript: all cDNA clones in your preferred vector: PRL (NM_004248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRL
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRL
      QuantiTect SYBR Green Assays in human, mouse, rat PRL
      QuantiFast Probe-based Assays in human, mouse, rat PRL

    Additional mRNA sequence: 

    BC015850.1 BC088370.1 D00411.1 DQ839492.1 GQ305133.1 M29386.1 U75583.1 V00566.1 
    X54393.1 X54394.1 

    Selected DOTS entries (see all 37):

    DT.100893336  DT.216750  DT.100893346  DT.92459805  DT.100893365  DT.100893341  DT.100893374  DT.100893371 
    DT.100893360  DT.95181547  DT.100893338  DT.95283527  DT.100893355  DT.100893368  DT.100893372  DT.95181598 
    DT.100842013  DT.100893325  DT.121387776  DT.95181552  DT.95181593  DT.100893324  DT.100893332  DT.100893334 

    1041 AceView cDNA sequences (see top 24):

    CD107994 CD239749 CD106785 CD106637 CD105814 CD106883 CD236716 CD108070 
    CD107493 CD106717 CD105418 CD243111 CD109161 CD518766 CD251647 CD108583 
    CD239714 CD106713 CD242668 CD519045 CD107878 CD106101 CD251270 AA371842 
    AA371794 CD107815 CD242863 CD106867 CD106462 CD250885 CD106290 CD107600 
    CD107142 CD251157 CD105459 CD251113 CD513048 CD106427 BX106632 CD106918 
    CD106496 BM712875 CD109109 CD556652 CD243100 CD106396 CD107514 CD518211 
    AA371713 CD238892 CD108026 CD108266 CD106943 CD108778 CD108474 CD250869 
    CD514046 CD108633 CD106737 CD107921 CD108894 CD106099 CD105846 BM723334 
    CD108480 CD107483 CD243041 CD106017 CD239773 CD108225 CD513801 CD239820 
    CD239746 BM673732 CD105695 CD236964 CD106349 CD105775 CD251262 CD108021 
    M58594 CD251505 CD107118 CD513586 CD105648 CD250884 CD108638 BX336440 
    CD238274 CD107842 T29541 CD108216 CR596710 CD108102 CD105371 CD106131 
    CD242839 CD105722 CD105928 CD108019 CD106577 CD556859 CD514084 CD242329 
    CD108227 CD106237 CD108806 CD107114 CD108150 CD243076 CD108091 BC015850 
    CD239782 CD109155 CD513482 CD239693 CD251668 CD106243 CD107860 CD107243 
    CD108217 CD239720 CD242847 CD237013 CD243132 CD108032 CD108484 CD107449 
    CD239750 CD513601 CD239780 CD239547 CD251144 AV753278 CD106477 AV752034 
    CD239676 CD105939 CD105905 AA371662 CD250871 CD105439 CD108824 CD108614 
    CD108115 CD238232 CD106978 CD106406 CD243107 CD239178 CD108270 CD250978 
    CD109087 CD105883 CD108703 CD238542 CD106694 CD238030 CD107309 CD109196 
    CD239727 CD251266 AV753515 CD239882 CD238413 CD107678 CD239398 BF511062 
    CD109230 CD105236 CD251482 BG393056 CD238552 CD239665 CD251508 CD106653 
    CD239044 CD251218 CD105487 CD108473 CD107115 CD251416 CD251546 CR608839 
    CD106782 CD108001 CD238862 CD109012 CD251609 CD108933 CD108179 CD238951 
    BM682199 CD239046 CD243014 CD251762 CD251316 CD238851 AV750987 CD107233 
    CD238511 AV752096 CD107546 CD242700 CD108531 CD237048 CD108129 CD242252 
    CD237632 CD556331 CD242756 BX336439 CD107141 CD239191 CD513845 CD237888 
    CD238486 CD238191 CD238859 CD236837 CD238298 CD237041 CD238698 CD238601 
    CD609881 CD514032 AV751541 CD236919 CD556786 CD242797 CD512773 CD238228 
    CD239042 AV752914 CD237069 CD237994 CD513211 CD239945 CD513912 CD512894 
    CD240010 CD238070 CD237793 CD237502 CD238930 CD242985 CD106086 CD107606 
    CD238705 AV751947 AV750066 CD516390 AV752057 CD107727 CD108488 CD556297 
    CD237428 CD556890 CD238896 CD239111 CD239032 CD519594 M29386 AA371775 
    CD237149 AA371814 CD238976 CD609877 AV751384 AV753127 CD239332 BU598743 
    CD109210 CD239093 CD238794 CD238765 CD239623 CD105752 CD238654 CD237113 
    CD242477 AA371344 AA371868 CD237821 CD237810 BQ441738 CD556804 CD236985 
    CD251797 CD107077 CD513430 CD242455 AV751604 BX348372 AV748123 CD242742 
    CD105478 CD108725 CD557033 CD238884 CD237955 CD237877 CD236807 CD108717 
    CD239470 CD251473 CD242859 CD239853 CD239033 CD238352 CD242793 BU192090 
    CD238135 CD237896 CD556460 CD239318 NM_000948 CD243183 CD556543 CD236945 
    CD237630 CD239215 CD237125 CD238238 CD239100 CD242372 CD238978 CD609875 
    CD106572 CD513842 CD237090 CD239079 AA371763 CD513829 CD238772 CD238853 
    CD238385 AV745890 CD239038 CD236797 CD239888 CD242958 CD239326 CD513187 
    CD239027 BX380686 CD108665 CD238731 CD242551 CD106423 CD556806 CD238887 
    CD242312 D00411 CD557015 CD609880 CD251611 CD239362 CD236856 CD513333 
    CD239384 CD238925 AV752423 CD556755 CD238162 CD239291 CD243003 CD106209 
    X54394 CD556944 CD105545 CD239769 CD609878 CD242633 CD239345 CD240017 
    CD512718 CD239698 CD512943 CD238535 CD239393 AV751448 CD238416 CD238956 
    CD237008 CD236988 AA037488 CD237692 CD556560 CD239592 AA371800 CD239315 
    CD240037 CD107543 BX339442 CD238755 AV747404 CD106078 CD108168 CD239584 
    AV753290 CD238900 CD556312 CD105310 CD236929 CD239184 CD237044 CD242636 
    AV751661 CD514096 CD107432 CD239231 AA371661 CD251430 CD513218 CD236965 
    CD513647 CD239909 CD519470 CD237284 CD251598 CD108411 CD238229 CD239992 
    CD238856 CD239816 CD106414 CD513942 CD512939 CD238664 CD107540 CD106118 
    CD238087 AV752536 CD239915 CD239597 CD237817 CD239460 CD105263 AA693912 
    BX380174 CD108855 CD107718 CD251255 CD239195 CD237960 AV747026 CD238632 
    CD106835 CD107478 CD238587 CD238439 CD239078 CD109108 CD513945 CD237778 
    CD239760 CD238633 CD609883 V00566 CD236924 CD251429 CD242345 CD237803 
    CD251517 CD239382 CD513379 CD237045 CD108472 CD236980 CD238397 CD513826 
    CD238517 CD237042 CD237848 CD237786 U75583 CD518926 CD251021 CD239603 
    CD250947 CD107480 CD239799 CD237872 CD239635 CD239363 CD513254 CD237963 
    CD518911 CD239916 CD013952 CD239663 AV747817 CD238910 CD251660 CD105974 
    CD107688 AV753215 CD239557 AV752418 CD108493 CD238628 BI753701 CD243095 
    CD238702 CD238415 CD240055 AA035447 CD239210 CD105805 CD238713 CD238435 
    CD239030 CD238480 CD516411 CD108519 AA371874 CD239900 CD239655 AV747660 
    CD108333 CD238858 CD513541 CD239001 CD238612 AV752338 CD239811 CD239907 
    CD105579 CD238683 AI123963 AV753032 CD106332 CD239929 CD250905 CD239054 
    AA705538 CD239360 AV753552 CD105203 X54393 CD513744 CD238997 CD514064 
    CD513599 CD236904 CD239536 BG504305 CD242981 CD243031 CD239274 BX339441 
    CD239903 CD238536 CD237773 BG505714 CD242335 CD513353 CD239429 CD557052 
    AV751629 AV752820 CD251306 AV747347 AV746121 CD242719 CD237162 AV746049 
    CD238844 AV752497 AV754348 CD513524 CD237618 CD237585 AV745245 AA704863 
    AV747135 CD516351 AV753239 AV748322 CD556639 CD238992 AV747648 AV747839 
    AV747855 CD237148 AV753254 AV746220 CD609879 AV745886 CD518864 CD106369 
    AV748528 AV751005 AV748721 CD556951 CD237669 AV751323 CD237101 CD108983 
    CD237401 CD242803 AV747998 AV747659 CD239277 CD239541 CD237820 AV754820 
    AA133920 AV751847 CD237324 CD237120 CD237175 H51034 D78866 CD239448 
    CD237214 AA661993 CD242350 CD107741 CD239502 CD513233 CD238638 CD107458 
    AV747587 CD609882 CD512736 AA371726 H83930 AV745824 CD236711 AV745282 
    CD109058 AV745743 CD242817 AV751755 CD237571 CD237488 CD243002 CD512863 
    CD519615 AV747791 CD238677 CD239083 CD237203 CD237657 CD518896 CD239941 
    CD556424 CD237265 AV748430 AV752380 AV750775 AV754448 CD236833 CD237172 
    CD237698 AV751708 AV746212 CD512953 CD239048 AV752728 AV750456 AV748434 
    CD237364 AV753207 CD106551 CD105194 N69665 AV751666 CD609874 CD609876 
    CD237123 CD239134 AV745785 CD108963 AV753292 AV753141 AV751291 CD237918 
    CD236782 CD513661 AV753532 CD243131 CD237706 AV745802 CD239630 AV746922 
    CD237270 CD242953 CD237736 CD251785 CD516328 AV746151 AV752352 AV749842 
    AV748364 CD239316 AV747560 CD107136 CD236717 AV746115 AV750465 CD237259 
    AV748269 AV749973 AV752924 AV746053 AV750334 AV750855 CD512979 CD252113 
    AV750941 AI056744 AV754485 CD107894 AV747243 AV750340 CD105885 AV745532 
    AV749454 CD239959 AV750090 AV745441 CD512818 AV747349 AV750958 AV745866 
    BX380685 AV749259 N31956 AV749818 AV745223 BQ429729 AV748468 AV747960 
    AV747325 AV746143 AV753978 CD107348 AV749690 AV745557 CD239873 CD237742 
    CD108697 AV751275 CD251744 AV748317 AV746709 CD251063 CD239076 H51033 
    AV754803 AV745558 AA130238 AV750597 AV750337 AV747716 AV748283 AA371720 
    AV746043 CD242564 CD513357 CD106499 AV752760 AV746405 AV749361 AV751211 
    CD237559 AV749434 AV745898 CD237174 AV745434 CD237236 D59032 AA371723 
    AV745191 CD239314 AV749747 AV747942 CD236816 AV753132 CD107122 AV746811 
    CD251145 CD105569 AV745989 CD237396 AV745856 CD105834 AV747594 CD251404 
    AV753525 CD518885 AV749638 CD242284 CD556958 CD517967 CD239136 CD556345 
    CD238613 AV750840 CD237566 CD513117 AA151622 AV747222 AV750162 AV751846 
    AV749438 AV752363 AV747703 AV750335 CD106130 AV748194 AV750587 AV745394 
    AV751136 AV748366 AV752015 CD251721 CD238655 AV747242 AV751935 CD106158 
    CD236931 CD513729 CD251015 CD513268 H83788 AV749822 AV747940 AV748658 
    AV748237 CD237431 AV747396 AV750756 AV747409 AV750675 AV752180 AA923706 
    AV746860 AV747569 AV746024 AV746995 AV749619 AV745376 AV745505 AV751375 
    AV753411 AV751913 CB051796 CD236939 AV753004 CD513339 AV750333 CD519528 
    AV748153 AV749871 AV748087 AV749464 AV750795 CD243021 AV747246 AV747197 
    CD237475 CD237593 AV748052 AV747211 CD106769 AV750123 AV752782 AV750081 
    CD556381 AV748090 N53569 AV754397 AV753265 AV752125 AV745602 CD106830 
    AV754768 CD243276 AV749873 AA884187 CD237535 AV750426 AV750669 AV752956 
    AV746326 AV747687 CD236685 AV749620 AV748902 AV745899 CD513055 AV749199 
    AV745195 AV747261 CD609885 CD514117 AV748232 CD238915 AV751273 AI241435 
    AV746545 CD105381 CD242774 AV754867 AV746474 AV747192 AV746983 BG184483 
    AV750148 AV748845 CD239074 AV747941 CD609884 AV746717 CD251242 AV750354 
    AA709022 CD238785 AV747017 AV748308 AV745599 AV745622 AV745351 CD514017 
    AV746204 CD513928 AV747141 AV751341 AV752207 AV746345 AV747238 R27857 
    AV746972 CD251192 CD556986 AV746765 CD556592 AV750187 AV747525 AV747267 
    AV748699 CD251351 W76563 AV746792 CD242735 W72598 CD108011 AV745993 
    AV749035 AV747847 AV751387 AV747688 AV751203 AV749243 N72337 CD239739 
    AV751266 CD105451 AV753604 AV748906 CD106775 AV747681 CD251650 AV748188 
    AV746644 AV750296 AV751873 CD106856 CD106979 AV751694 AV751579 AV753217 
    AV746935 AV750308 AV749588 AV745231 AV747462 AV752155 AV752532 AV749905 
    AV746000 AV750451 AV752662 CD237217 AV751442 AV751564 N72528 AV748145 
    AV750403 CD556589 AV749501 CD242459 AV748286 CD512812 AV749740 CD239836 
    AV745123 AV750218 AV752048 AV748828 CD236814 AV750346 N94273 AV749993 
    CD239551 CD556818 AV750670 CD609893 CD108827 AV750758 CD106337 CD107124 
    CD105602 AV747935 CD609891 AV753744 CD513728 AV745999 CD609887 CD239366 
    AA035474 AV751867 AA371556 AV750764 CD513536 CD242917 CD609892 CD609894 
    CD609886 CD237556 CD239838 CD609890 CD609895 CD242401 AV746361 CD609888 
    CD609889 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRL (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                          -                 -                       -                     
    SP2:                          -                 -                       -                     
    SP3:                          -                 -                       -                     
    SP4:                          -                 -           -     -     -                     
    SP5:                          -                 -                                             


    ECgene alternative splicing isoforms for PRL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGGGTGTA
    PRL Expression
    About this image


    PRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             T-Cytotoxic Cells Thymus
    PRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1905
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRL: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRL
    OriGene qSTAR qPCR primer pairs in human, mouse for PRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRL
    QuantiTect SYBR Green Assays in human, mouse, rat PRL
    QuantiFast Probe-based Assays in human, mouse, rat PRL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for PRL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prl1 , 5 prolactin1, 5 71.85(n)1
    61.33(a)1
      13 (12.25 cM)5
    191091  NM_011164.21  NP_035294.21 
     270575775 
    chicken
    (Gallus gallus)
    Aves PRL1 prolactin 72.06(n)
    70.1(a)
      396453  NM_205466.2  NP_990797.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRL6
    prolactin
    65(a)
    1 ↔ 1
    4(54981767-54989741)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD302094.12   -- 73.67(n)    CD302094.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prl6
    prolactin
    34(a)
    1 ↔ 1
    3(32478893-32482876) ENSDARG00000037946


    ENSEMBL Gene Tree for PRL (if available)
    TreeFam Gene Tree for PRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PRL (see all 354)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841026651,2
    --22208998(+) TTGTAC/GAATGA 2 -- ds50010--------
    rs1411613951,2
    C--22209017(+) ATTAAC/TAATCT 2 -- ds50010--------
    rs1434595781,2
    --22209030(+) CTCTTC/TGATTC 2 -- ds50010--------
    rs1466753541,2
    --22209133(+) TCTGAC/TAAGAA 2 -- ds50010--------
    rs1401052691,2
    --22209135(+) TGATAA/TGAACT 2 -- ds50010--------
    rs93585301,2
    H--22209300(+) TACAAC/TTAAAA 2 -- ut314Minor allele frequency- T:0.00NS EA 418
    rs1502890101,2
    --22209310(+) AGAAGC/TTTGCA 2 -- ut310--------
    rs1886419431,2
    C--22209322(+) TGGAAC/TGGATC 2 -- ut310--------
    rs2020533991,2
    --22209342(+) CTTCTC/TAGAAA 2 -- ut310--------
    rs2008313761,2
    --22209367(+) GTGGGC/TTTAGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PRL (22287475 - 22303082 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830604CNV Loss17160897

    Human Gene Mutation Database (HGMD): PRL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRL
    DNA2.0 Custom Variant and Variant Library Synthesis for PRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176760    OMIM disorders: --

    Selected diseases for PRL (see all 66):    
    About MalaCards
    hypogonadotropism    sheehan syndrome    empty sella syndrome    choristoma
    prolactin producing pituitary tumor    schizophreniform disorder    hyperprolactinemia    growth hormone secreting pituitary adenoma
    pituitary carcinoma    obstructive hydrocephalus    sexual disorder    pituitary apoplexy
    pedophilia    scotoma    6-pyruvoyl-tetrahydropterin synthase deficiency    prolactinoma
    impotence    amenorrhea    peripartum cardiomyopathy    generalized resistance to thyroid hormone

    Selected diseases from the University of Copenhagen DISEASES database for PRL (see all 29):
    Hyperprolactinemia     Pituitary adenoma     Adenoma     Amenorrhea
    Neuroendocrine tumor     Acromegaly     Hypothyroidism     Hypopituitarism
    Hypogonadism     Infertility     Cushing's syndrome     Polycystic ovary syndrome
    Empty sella syndrome     Anovulation     Hypoglycemia     Sexual dysfunction
    Breast cancer     Gynecomastia     Diabetes insipidus     Pituitary apoplexy

    Find genes that share disorders with PRL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRL gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperprolactinemia 97.2 764 8456892 (5), 7899431 (5), 9156042 (5), 16817144 (5) (see all 99)
    prolactinoma 95.4 432 12012125 (6), 18426817 (5), 1903012 (5), 12574225 (4) (see all 99)
    macroprolactinoma 92.5 95 8737186 (6), 10931080 (5), 8729527 (3), 10216513 (3) (see all 60)
    pituitary adenoma 91.3 250 8392915 (5), 1910948 (3), 14615416 (3), 12713252 (3) (see all 99)
    microprolactinoma 91.3 77 10931080 (5), 14616880 (4), 10216513 (3), 1774132 (2) (see all 48)
    pituitary tumors 87.7 119 15251707 (3), 2325501 (2), 10933752 (2), 7664652 (2) (see all 90)
    acromegaly 83.2 73 1574954 (2), 8531896 (2), 8127416 (2), 15473133 (2) (see all 52)
    adenoma 82.3 774 8949563 (7), 1625993 (6), 8162255 (5), 8890999 (5) (see all 99)
    hypogonadism 80 51 8733264 (3), 2099670 (1), 10699620 (1), 11207632 (1) (see all 36)
    panhypopituitarism 78.9 26 10698595 (2), 2045062 (1), 8805025 (1), 9285205 (1) (see all 20)

    Genetic Association Database (GAD): PRL
    Human Genome Epidemiology (HuGE) Navigator: PRL (67 documents)
    Tumor Gene Database (TGDB): PRL

    Export disorders for PRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRL gene, integrated from 10 sources (see all 4459):
    (articles sorted by number of sources associating them with PRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort. (PubMed id 18053149)1, 4, 9 Lee S.A....Stram D.O. (BMC Med. Genet. 2007)
    2. Association of prolactin and its receptor gene regions with familial breast cancer. (PubMed id 16434456)1, 4, 9 Vaclavicek A....FAPrsti A. (J. Clin. Endocrinol. Metab. 2006)
    3. Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus. (PubMed id 12559630)1, 4, 9 Mellai M....Momigliano-Richiardi P. (Hum. Immunol. 2003)
    4. Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk. (PubMed id 16214922)1, 4, 9 Skibola C.F....Holly E.A. (amp 2005)
    5. Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (PubMed id 19897676)1, 4, 9 Courtillot C....Touraine P. (J. Clin. Endocrinol. Metab. 2010)
    6. Extrapituitary prolactin promoter polymorphism in Czech patients with systemic lupus erythematosus and rheumatoid arthritis. (PubMed id 17468404)1, 4, 9 FojtA-kovA! M....DostA!l C. (Ann. Rheum. Dis. 2007)
    7. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PubMed id 21623375)1, 4 Albagha O.M....Ralston S.H. (Nat. Genet. 2011)
    8. No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. (PubMed id 20547007)1, 4 Strauss J.S....Kennedy J.L. (Psychoneuroendocrinology 2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. (PubMed id 20716560)1, 4 Hanna C.W....Robinson W.P. (Hum. Reprod. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5617 HGNC: 9445 AceView: PRL Ensembl:ENSG00000172179 euGenes: HUgn5617
    ECgene: PRL Kegg: 5617 H-InvDB: PRL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRL Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Prolactin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRL gene:
    Search GeneIP for patents involving PRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Small Molecules at EMD Millipore
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     Antibodies for PRL (Prolactin)   Browse Cell Culture Products  
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     OriGene Antibodies for PRL   OriGene RNAi products in human, mouse, rat for PRL  
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     OriGene MassSpec for PRL   OriGene clones in human, mouse for PRL  
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     OriGene ORF clones in mouse, rat for PRL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRL   OriGene Custom Protein Services for PRL  

     
     
     Block miRNA regulation of human, mouse, rat PRL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRL Predesigned siRNA for gene silencing in human, mouse, rat PRL
     QuantiFast Probe-based Assays in human, mouse, rat PRL QuantiTect SYBR Green Assays in human, mouse, rat PRL
     PCR Arrays including human, mouse, rat PRL Search Chromatin IP Primers for PRL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRL  GeneGlobe Interaction Network for PRL
     Regulatory tfbs in PRL promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRL GenScript cDNA clones with any tag delivered in your preferred vector for PRL
     GenScript Custom Assay Services for PRL GenScript Custom overexpressing Cell Line Services for PRL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PRL
     Proteins for PRL
     Cell Lysates for PRL
     cDNA Clones for PRL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for PRL
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PRL
     Proteins for PRL
     Antibodies for PRL
     ELISAs for PRL
     CLIAs for PRL



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRL
     Gene Synthesis
     Protein Engineering
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRL
     SwitchGear 3'UTR luciferase reporter plasmids for PRL
     SwitchGear Promoter luciferase reporter plasmids for PRL
     ThermoFisher Antibody for PRL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRL
     LSBio Antibodies in human, mouse, rat for PRL
     Browse compounds at ApexBio
     Search Addgene for plasmids for PRL
      Search eBioscience for proteins for PRL
      Search eBioscience for elisas for PRL
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
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     antibodies-online antibodies for PRL (310 products)
     antibodies-online kits for PRL (66 products)
     antibodies-online peptides for PRL
     antibodies-online proteins for PRL (133 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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