|
|
protein kinase, Y-linked, pseudogene(Previous names: protein kinase, Y-linked )
| |
Aliases
for PRKY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Protein Kinase, Y-Linked, Pseudogene1 2 | | PRKXP31 2 | | PRKYP1 2 | | Protein Kinase, Y-Linked1 | | EC 2.7.11.13 | | EC 2.7.118 |
| External Ids: | HGNC: 94441 | Entrez Gene: 56162 | Ensembl: ENSG000000997257 | OMIM: 4000085 | UniProtKB: O439303 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408124 | |
Export aliases for PRKY gene to outside databasesPrevious GC identifers: GC0YP007107 GC0YP006844 GC0YP007185 GC0YP004701
Summaries
for PRKY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKY:
This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The geneis classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts beingcandidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between thisgene and a related gene on chromosome X is a frequent cause of XX males and XY females. (provided by RefSeq, Jul 2010)
Gene Wiki entry for PRKY
|
Genomic Views
for PRKY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011896.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKY gene promoter:
RORalpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2PRKY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP007142: view genomic region
(about GC identifiers)
Start:
|
7,142,013 bp from pter |
End:
|
7,249,589 bp from pter |
Size:
|
107,577 bases |
Orientation:
|
plus strand |
|
Proteins
for PRKY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930 (See
protein sequence)Recommended Name: Putative serine/threonine-protein kinase PRKY Size: 277 amino acids; 31708 Da
Caution: Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the Xchromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay
Secondary accessions: O15348 O15349Explore the universe of human proteins at neXtProt for PRKY: NX_O43930
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43930
4/8 DME Specific Peptides for PRKY (O43930) (see all 8)
PRKY Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
PRKY Antibody Products:
Assay Products for PRKY: |
Protein
Domains /
Families
for PRKY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKY for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43930ProtoNet protein and cluster: O43930 UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamilySimilarity: Contains 1 protein kinase domain |
Function
for PRKY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930Catalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for PRKY:serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic recombinationwith PRKX,leading to XX male
Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for PRKY | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKY |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
PRKY for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRKY:
|
Pathways & Interactions
for PRKY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRKY
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PRKY for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRKY
3 HMDB Compounds for PRKY About this table
Search CenterWatch for drugs/clinical trials and news about PRKY
|
Transcripts
for PRKY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKY gene: NM_002760.3 Unigene Cluster for PRKY: Protein kinase, Y-linked, pseudogene Hs.584730 [show with all ESTs]Unigene Representative Sequence: NR_0280625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528056(uc004fre.3) ENST00000533551 ENST00000495163 ENST00000472666
ENST00000362758
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for PRKY | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKY |
Additional cDNA sequence: BC074851.2 BC074852.2 NR_028062.1 Y10484.1 Y10485.1 3 DOTS entries: DT.95273058 DT.95153312 DT.100018653 24/57 AceView cDNA sequences (see all 57): BC074851 BQ082031 AA490258 CA446672 AW593234 CB242248 AI929286 BX107976 AI651473 BC074852 AA767129 AA602302 AA602461 AI417940 Y10484 AA769513 N34383 BG698237 Y15801 AW590914 BP354792 AI825463 AI929361 BQ002885
GeneLoc Exon Structure
|
Expression
for PRKY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for PRKY
SOURCE GeneReport for Unigene cluster: Hs.584730
UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for PRKY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKY
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRKY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKY |
Orthologs
for PRKY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRKY gene from 1/2 species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
soybean
(Glycine max) |
eudicotyledons |
BQ629829.12 |
-- |
74.77(n) |
|
BQ629829.1 |
Species with no ortholog for PRKY
ENSEMBL Gene Tree for PRKY (if available)
TreeFam Gene Tree for PRKY (if available) |
Paralogs
for PRKY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PRKY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKY (7142013 - 7249589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKY: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for PRKY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKY for disorders About GeneDecksing
OMIM gene information: 400008
OMIM disorders: --
UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930
Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocationt(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sexreversal disorder in XX males and XY females
3  diseases for PRKY: About MalaCardsgonadal dysgenesis sex reversal gonadoblastoma
Human Genome Epidemiology (HuGE) Navigator: PRKY (1 document)
Export disorders for PRKY gene to outside databases
|
Publications
for PRKY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKY gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with PRKY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PubMed id 9302280)1, 2, 9 Schiebel K.... Rappold G.A. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13. (PubMed id 9154127)1, 2 Schiebel K....Rappold G. (1997)
- The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. (PubMed id 7633447)1, 3 Klink A.... Rappold G. (1995)
- Perioperative genomic profiles using structure-specif ic oligonucleotide probes. (PubMed id 19474452)1 Hogan K.J....Domanico M.J. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A selective difference between human Y-chromosomal DNA haplotypes. (PubMed id 9889101)1 Jobling M.A....Tyler-Smith C. (1998)
- High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. (PubMed id 9088640)1 Glaser B....Schempp W. (1997)
- The prpZ gene cluster encoding eukaryotic-type Ser/Thr protein kinases and phosphatases is repressed by oxidative stress and involved in Salmonella enterica serovar Typhi survival in human macrophages. (PubMed id 18312574)9 Faucher S.P....Le Moual H. (2008)
|
External Searches for PRKY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRKY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRKY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRKY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRKY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRKY gene:
Search GeneIP for patents involving PRKY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRKY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PRKY | | OriGene shRNA RFP for PRKY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKY | | | OriGene Protein Over-expression Lysate for PRKY | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRKY | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRKY | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRKY | | OriGene Custom Protein Services for PRKY | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKY | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKY |
| |
 |  |  |  | |
| | | | Search Tocris compounds for PRKY |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PRKY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKY |
|  |  |  | | | | Search ThermoFisher Antibodies for PRKY |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKY |
|
|
|
|
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 100 solr: 1.4
|
