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Aliases for PRKY Gene

Aliases for PRKY Gene

  • Protein Kinase, Y-Linked, Pseudogene 2 3 5
  • Protein Kinase, Y-Linked 2
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • PRKXP3 3
  • PRKYP 3

External Ids for PRKY Gene

Previous GeneCards Identifiers for PRKY Gene

  • GC0YP007107
  • GC0YP006844
  • GC0YP004701
  • GC0YP007142

Summaries for PRKY Gene

Entrez Gene Summary for PRKY Gene

  • This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]

GeneCards Summary for PRKY Gene

PRKY (Protein Kinase, Y-Linked, Pseudogene) is a Pseudogene. GO annotations related to this gene include protein serine/threonine kinase activity.

Gene Wiki entry for PRKY Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKY Gene

Genomics for PRKY Gene

Regulatory Elements for PRKY Gene

Enhancers for PRKY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0YF007272 0.9 FANTOM5 ENCODE 0.8 +0.7 730 4.3 SOX13 ELF3 CTCF SAP130 ZFP64 TEAD4 ARID4B SIN3A DMAP1 THRB AMELY PRKY RN7SKP282
GH0YF007278 0.7 FANTOM5 ENCODE 0.4 +7.1 7141 5.3 SOX13 TBX3 SOX5 FOXA3 FOXA1 MIXL1 PRKY RN7SKP282
GH0YF007289 0.2 ENCODE 0.3 +17.0 17045 3.5 PRKY RN7SKP282
GH0YF007239 0.4 ENCODE 0.3 -33.5 -33503 2.4 PRKY PIR43812
GH0YF007310 0.4 ENCODE 0.3 +37.1 37083 0.3 GATAD2A CTCF CEBPB CEBPG RN7SKP282 PRKY
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRKY on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKY Gene

Chromosome:
Y
Start:
7,273,972 bp from pter
End:
7,381,548 bp from pter
Size:
107,577 bases
Orientation:
Plus strand

Genomic View for PRKY Gene

Genes around PRKY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKY Gene

Proteins for PRKY Gene

  • Protein details for PRKY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43930-PRKY_HUMAN
    Recommended name:
    Putative serine/threonine-protein kinase PRKY
    Protein Accession:
    O43930
    Secondary Accessions:
    • O15348
    • O15349

    Protein attributes for PRKY Gene

    Size:
    277 amino acids
    Molecular mass:
    31708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRKY Gene

Selected DME Specific Peptides for PRKY Gene

Post-translational modifications for PRKY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRKY Gene

Gene Families for PRKY Gene

Protein Domains for PRKY Gene

Suggested Antigen Peptide Sequences for PRKY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43930

UniProtKB/Swiss-Prot:

PRKY_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKY: view

Function for PRKY Gene

Molecular function for PRKY Gene

GENATLAS Biochemistry:
serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic recombination with PRKX,leading to XX male
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for PRKY Gene

Gene Ontology (GO) - Molecular Function for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKY: view
genes like me logo Genes that share phenotypes with PRKY: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKY

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRKY Gene

Localization for PRKY Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PRKY Gene

Pathways & Interactions for PRKY Gene

SuperPathways for PRKY Gene

No Data Available

Interacting Proteins for PRKY Gene

Selected Interacting proteins: O43930-PRKY_HUMAN for PRKY Gene via IID

Gene Ontology (GO) - Biological Process for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PRKY: view

No data available for Pathways by source and SIGNOR curated interactions for PRKY Gene

Drugs & Compounds for PRKY Gene

(2) Drugs for PRKY Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
cyclic amp Experimental Pharma 0

(1) Additional Compounds for PRKY Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PRKY: view

Transcripts for PRKY Gene

mRNA/cDNA for PRKY Gene

Unigene Clusters for PRKY Gene

Protein kinase, Y-linked, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKY Gene

No ASD Table

Relevant External Links for PRKY Gene

GeneLoc Exon Structure for
PRKY
ECgene alternative splicing isoforms for
PRKY

Expression for PRKY Gene

mRNA expression in normal human tissues for PRKY Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKY Gene:

PRKY

SOURCE GeneReport for Unigene cluster for PRKY Gene:

Hs.584730

mRNA Expression by UniProt/SwissProt for PRKY Gene:

O43930-PRKY_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PRKY: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRKY Gene

Orthologs for PRKY Gene

Evolution for PRKY Gene

ENSEMBL:
Gene Tree for PRKY (if available)
TreeFam:
Gene Tree for PRKY (if available)

No data available for Orthologs for PRKY Gene

Paralogs for PRKY Gene

genes like me logo Genes that share paralogs with PRKY: view

No data available for Paralogs for PRKY Gene

Variants for PRKY Gene

Sequence variations from dbSNP and Humsavar for PRKY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs10429816 -- 7,329,374(+) ttgca(A/G)aagga intron-variant
rs1056374 -- 7,380,205(+) CTGCA(A/C)AATCA nc-transcript-variant
rs1056375 -- 7,380,227(+) ATTTC(C/T)CATTC nc-transcript-variant
rs111245629 -- 7,359,557(+) AATAA(A/T)GAAGG intron-variant
rs111400785 -- 7,349,226(+) CCTCC(C/T)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKY Gene

Variant ID Type Subtype PubMed ID
esv3577579 CNV gain 25503493
nsv1078153 CNV duplication 25765185
nsv7473 OTHER inversion 18451855

Relevant External Links for PRKY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRKY Gene

Disorders for PRKY Gene

UniProtKB/Swiss-Prot

PRKY_HUMAN
  • Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Relevant External Links for PRKY

Genetic Association Database (GAD)
PRKY
Human Genome Epidemiology (HuGE) Navigator
PRKY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKY

No disorders were found for PRKY Gene.

No data available for MalaCards and Genatlas for PRKY Gene

Publications for PRKY Gene

  1. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K. … Rappold G.A. (Hum. Mol. Genet. 1997) 3 4 22 64
  2. Perioperative genomic profiles using structure-specific oligonucleotide probes. (PMID: 19474452) Hogan K.J. … Domanico M.J. (Clin Med Res 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4 64
  5. FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13. (PMID: 9154127) Schiebel K. … Rappold G. (Cytogenet. Cell Genet. 1997) 3 4 64

Products for PRKY Gene

Sources for PRKY Gene

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