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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKY Gene

pseudogene   GIFtS: 49
GCID: GC0YP007142

Protein Kinase, Y-Linked, Pseudogene

(Previous names: protein kinase, Y-linked)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Kinase, Y-Linked, Pseudogene1 2
Protein Kinase, Y-Linked1
PRKXP32
PRKYP2
EC 2.7.11.13
EC 2.7.118

External Ids:    HGNC: 94441   Entrez Gene: 56162   Ensembl: ENSG000000997257   OMIM: 4000085   UniProtKB: O439303   
ORGUL members:         
NONCODE14:n408124      

Export aliases for PRKY gene to outside databases

Previous GC identifers: GC0YP007107 GC0YP006844 GC0YP007185 GC0YP004701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKY Gene:
This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The
gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts
being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination
between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. (provided by
RefSeq, Jul 2010)

GeneCards Summary for PRKY Gene: 
PRKY (protein kinase, Y-linked, pseudogene) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with PRKY include gonadoblastoma, and gonadal dysgenesis. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding.

Gene Wiki entry for PRKY Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_011896.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKY gene promoter:
         RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKY promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

PRKY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKY gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP007142:  view genomic region     (about GC identifiers)

Start:
7,142,013 bp from pter      End:
7,249,589 bp from pter
Size:
107,577 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930 (See protein sequence)
Recommended Name: Putative serine/threonine-protein kinase PRKY  
Size: 277 amino acids; 31708 Da
Caution: Could be the product of a pseudogene. Highly similar to PRKX in the pseudoautosomal region of the X
chromosome, the transcripts specific of that gene are potential candidates for nonsense-mediated decay
Secondary accessions: O15348 O15349

Explore the universe of human proteins at neXtProt for PRKY: NX_O43930

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43930

  • 4/8 DME Specific Peptides for PRKY (O43930) (see all 8)
     GHIKLTD  IKLTDFG  TDFGFAK  LGILIFE 

    PRKY Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, Y-linked, pseudogene 
    Protein kinase A (PKA) family

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O43930

    ProtoNet protein and cluster: O43930

    UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 protein kinase domain


    PRKY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRKY_HUMAN, O43930
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for PRKY:
    serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic
    recombination with PRKX,leading to XX male

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
         
    PRKY for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKY:
     Decreased substrate adherent c  Increased colony dispersion (i 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRKY

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9154127

    PRKY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PRKY

    3 HMDB Compounds for PRKY    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about PRKY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKY gene: 
    NM_002760.3  

    Unigene Cluster for PRKY:

    Protein kinase, Y-linked, pseudogene
    Hs.584730  [show with all ESTs]
    Unigene Representative Sequence: NR_028062
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528056(uc004fre.3) ENST00000533551 ENST00000495163 ENST00000472666
    ENST00000362758
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    Additional mRNA sequence: 

    BC074851.2 BC074852.2 NR_028062.1 Y10484.1 Y10485.1 

    3 DOTS entries:

    DT.95273058  DT.95153312  DT.100018653 

    24/57 AceView cDNA sequences (see all 57):

    AA767129 BC074852 AI417940 AA602461 AA490258 CA446672 BC074851 AA602302 
    BQ082031 CB242248 AW593234 BX107976 AI651473 AI929286 NM_002760 CA309261 
    BG698237 AW590914 AW590240 BQ002885 BP354792 BP334112 BM838190 Y10484 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRKY Expression
    About this image


    Genevestigator expression for PRKY

    SOURCE GeneReport for Unigene cluster: Hs.584730

    UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PRKY
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKY gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    soybean
    (Glycine max)
    eudicotyledons BQ629829.12   -- 74.77(n)    BQ629829.1 


    ENSEMBL Gene Tree for PRKY (if available)
    TreeFam Gene Tree for PRKY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKY gene
    18/116 SIMAP similar genes for PRKY using alignment to 1 protein entry:     PRKY_HUMAN(see all similar genes):
    PRKX    PRKACA    KIN27    PRKACB    PRKACG    RPS6KA4
    RPS6KA1    PRKG1    PRKG2    RPS6KA3    RPS6KA2    RPS6KA6
    STK32A    AKT3    AKT1    DKFZp781N0293    ROCK1    ROCK2

    PRKY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/846 SNPs in PRKY are shown (see all 846)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31099891,2
    C--7141536(-) TCAGCG/CCCCTG 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs31163241,2
    C--7143650(-) CTCGTA/CCCACA 1 -- int10--------
    rs31163201,2
    C--7143700(+) attctC/Ttcttt 1 -- int1 trp30--------
    rs31099901,2
    C--7145620(-) tattaA/Ctattt 1 -- int10--------
    rs30970771,2
    C--7149682(+) gtgtaG/Ttatta 1 -- int11Minor allele frequency- T:0.00NA 2
    rs133052191,2
    C--7149924(+) gcTTGG/TAGTCT 1 -- int10--------
    rs30970781,2
    C--7151887(+) GGGATC/TTGCAT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1139922551,2
    C--7153375(+) GCATCC/TAGGGA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs562025601,2
    C--7155102(+) GTGGGA/GCACCT 1 -- int10--------
    rs30970851,2
    C--7157736(+) AAAACA/GGaaaa 1 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for PRKY (7142013 - 7249589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRKY:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7473OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 400008    OMIM disorders: --

    UniProtKB/Swiss-Prot: PRKY_HUMAN, O43930
  • Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation
    t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex
    reversal disorder in XX males and XY females

  • 2 diseases for PRKY:    About MalaCards
    gonadoblastoma    gonadal dysgenesis


    PRKY for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKY
    Human Genome Epidemiology (HuGE) Navigator: PRKY (1 document)

    Export disorders for PRKY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKY gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PRKY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PubMed id 9302280)1, 2, 9 Schiebel K.... Rappold G.A. (1997)
    2. Perioperative genomic profiles using structure-specif ic oligonucleotide probes. (PubMed id 19474452)1, 4 Hogan K.J....Domanico M.J. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
    5. FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13. (PubMed id 9154127)1, 2 Schiebel K....Rappold G. (1997)
    6. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. (PubMed id 7633447)1, 3 Klink A.... Rappold G. (1995)
    7. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. A selective difference between human Y-chromosomal DNA haplotypes. (PubMed id 9889101)1 Jobling M.A....Tyler-Smith C. (1998)
    10. High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. (PubMed id 9088640)1 Glaser B....Schempp W. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5616 HGNC: 9444 AceView: PRKY Ensembl:ENSG00000099725 euGenes: HUgn5616
    ECgene: PRKY H-InvDB: PRKY

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKY gene:
    Search GeneIP for patents involving PRKY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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