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Aliases for PRKY Gene

Aliases for PRKY Gene

  • Protein Kinase, Y-Linked, Pseudogene 2 3
  • Protein Kinase, Y-Linked 2
  • EC 4
  • EC 2.7.11 63
  • PRKXP3 3
  • PRKYP 3

External Ids for PRKY Gene

Previous GeneCards Identifiers for PRKY Gene

  • GC0YP007107
  • GC0YP006844
  • GC0YP004701
  • GC0YP007142

Summaries for PRKY Gene

Entrez Gene Summary for PRKY Gene

  • This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]

GeneCards Summary for PRKY Gene

PRKY (Protein Kinase, Y-Linked, Pseudogene) is a Pseudogene. GO annotations related to this gene include protein serine/threonine kinase activity.

Gene Wiki entry for PRKY Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKY Gene

Genomics for PRKY Gene

Regulatory Elements for PRKY Gene

Transcription factor binding sites by QIAGEN in the PRKY gene promoter:

Genomic Location for PRKY Gene

7,273,972 bp from pter
7,381,548 bp from pter
107,577 bases
Plus strand

Genomic View for PRKY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKY Gene

Proteins for PRKY Gene

  • Protein details for PRKY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative serine/threonine-protein kinase PRKY
    Protein Accession:
    Secondary Accessions:
    • O15348
    • O15349

    Protein attributes for PRKY Gene

    277 amino acids
    Molecular mass:
    31708 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRKY Gene

Proteomics data for PRKY Gene at MOPED

Selected DME Specific Peptides for PRKY Gene

Post-translational modifications for PRKY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for PRKY Gene

Protein Domains for PRKY Gene

Suggested Antigen Peptide Sequences for PRKY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43930
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKY: view

Function for PRKY Gene

Molecular function for PRKY Gene

GENATLAS Biochemistry:
serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase,involved in ectopic recombination with PRKX,leading to XX male
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for PRKY Gene

Gene Ontology (GO) - Molecular Function for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKY: view
genes like me logo Genes that share phenotypes with PRKY: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKY

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRKY Gene

Localization for PRKY Gene

Subcellular locations from

Jensen Localization Image for PRKY Gene COMPARTMENTS Subcellular localization image for PRKY gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRKY Gene

Pathways for PRKY Gene

SuperPathways for PRKY Gene

No Data Available

Interacting Proteins for PRKY Gene

Gene Ontology (GO) - Biological Process for PRKY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PRKY: view

No data available for Pathways by source for PRKY Gene

Compounds for PRKY Gene

(3) HMDB Compounds for PRKY Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
Cyclic AMP
  • Cyclic AMP
genes like me logo Genes that share compounds with PRKY: view

Transcripts for PRKY Gene

mRNA/cDNA for PRKY Gene

Unigene Clusters for PRKY Gene

Protein kinase, Y-linked, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKY

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKY Gene

No ASD Table

Relevant External Links for PRKY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKY Gene

mRNA expression in normal human tissues for PRKY Gene

SOURCE GeneReport for Unigene cluster for PRKY Gene Hs.584730

mRNA Expression by UniProt/SwissProt for PRKY Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with PRKY: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for PRKY Gene

Orthologs for PRKY Gene

Evolution for PRKY Gene

Gene Tree for PRKY (if available)
Gene Tree for PRKY (if available)

No data available for Orthologs for PRKY Gene

Paralogs for PRKY Gene

genes like me logo Genes that share paralogs with PRKY: view

No data available for Paralogs for PRKY Gene

Variants for PRKY Gene

Sequence variations from dbSNP and Humsavar for PRKY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1056374 -- 7,380,205(+) CTGCA(A/C)AATCA nc-transcript-variant
rs1056375 -- 7,380,227(+) ATTTC(C/T)CATTC nc-transcript-variant
rs2558648 -- 7,279,729(+) ctgtg(C/G)catgc intron-variant
rs2558649 -- 7,279,730(+) tgtgg(C/G)atgcc intron-variant
rs2728498 -- 7,275,032(+) GACAC(A/C)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKY Gene

Variant ID Type Subtype PubMed ID
nsv7473 OTHER Inversion 18451855

Relevant External Links for PRKY Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKY Gene

Disorders for PRKY Gene


  • Note=A chromosomal aberration involving PRKY is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKX. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Relevant External Links for PRKY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PRKY Gene.

No data available for MalaCards , OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PRKY Gene

Publications for PRKY Gene

  1. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K. … Rappold G.A. (Hum. Mol. Genet. 1997) 3 4 23
  2. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. (PMID: 7633447) Klink A. … Rappold G. (Hum. Mol. Genet. 1995) 2 3
  3. FISH localization of the human Y-homologue of protein kinase PRKX to Yp11.2 and two pseudogenes to 15q26 and Xq12->13. (PMID: 9154127) Schiebel K. … Rappold G. (Cytogenet. Cell Genet. 1997) 3 4
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PRKY Gene

  • Addgene plasmids for PRKY

Sources for PRKY Gene

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