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Aliases for PRKX Gene

Aliases for PRKX Gene

  • Protein Kinase, X-Linked 2 3
  • Serine/Threonine-Protein Kinase PRKX 3 4
  • Protein Kinase X-Linked 3 4
  • Protein Kinase PKX1 3 4
  • Protein Kinase X 3 4
  • PKX1 3 4
  • CAMP-Dependent Protein Kinase Catalytic Subunit PRKX 3
  • EC 2.7.11.1 4
  • EC 2.7.11 63
  • PrKX 4

External Ids for PRKX Gene

Summaries for PRKX Gene

Entrez Gene Summary for PRKX Gene

  • This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

GeneCards Summary for PRKX Gene

PRKX (Protein Kinase, X-Linked) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include identical protein binding and cAMP-dependent protein kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKX Gene

  • Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKX Gene

Genomics for PRKX Gene

Genomic Location for PRKX Gene

Start:
3,604,343 bp from pter
End:
3,713,634 bp from pter
Size:
109,292 bases
Orientation:
Minus strand

Genomic View for PRKX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKX Gene

Regulatory Elements for PRKX Gene

Proteins for PRKX Gene

  • Protein details for PRKX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51817-PRKX_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit PRKX
    Protein Accession:
    P51817
    Secondary Accessions:

    Protein attributes for PRKX Gene

    Size:
    358 amino acids
    Molecular mass:
    40896 Da
    Quaternary structure:
    • Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein kinase inhibitor/PKI proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1; involved in differentiation and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain).

neXtProt entry for PRKX Gene

Proteomics data for PRKX Gene at MOPED

Selected DME Specific Peptides for PRKX Gene

Post-translational modifications for PRKX Gene

Other Protein References for PRKX Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PRKX Gene

Gene Families for PRKX Gene

Suggested Antigen Peptide Sequences for PRKX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51817

UniProtKB/Swiss-Prot:

PRKX_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P51817
  • Contains 1 protein kinase domain.:
    • P51817
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.:
    • P51817
genes like me logo Genes that share domains with PRKX: view

Function for PRKX Gene

Molecular function for PRKX Gene

GENATLAS Biochemistry: serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=127 uM for ATP (in the presence of 10 mM magnesium chloride) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174}; KM=58 uM for kemptide (in the presence of 10 mM magnesium chloride) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174}; KM=6.7 uM for kemptide (in the presence of 1 uM Br-cAMP at 30 degrees Celsius) {ECO:0000269 PubMed:10026146, ECO:0000269 PubMed:12082174};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates.
UniProtKB/Swiss-Prot Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.
UniProtKB/Swiss-Prot Induction: Up-regulated by phorbol 12-myristate 13-acetate (PMA).

Enzyme Numbers (IUBMB) for PRKX Gene

Gene Ontology (GO) - Molecular Function for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004691 cAMP-dependent protein kinase activity IDA 10026146
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16491121
genes like me logo Genes that share ontologies with PRKX: view
genes like me logo Genes that share phenotypes with PRKX: view

miRNA for PRKX Gene

miRTarBase miRNAs that target PRKX

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKX Gene

Localization for PRKX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKX Gene

Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKX Gene COMPARTMENTS Subcellular localization image for PRKX gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA 10026146
genes like me logo Genes that share ontologies with PRKX: view

Pathways for PRKX Gene

genes like me logo Genes that share pathways with PRKX: view

Gene Ontology (GO) - Biological Process for PRKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 21684272
GO:0001935 endothelial cell proliferation IMP 21684272
GO:0006468 protein phosphorylation --
GO:0007155 cell adhesion IMP 21684272
GO:0018105 peptidyl-serine phosphorylation IDA 16491121
genes like me logo Genes that share ontologies with PRKX: view

Compounds for PRKX Gene

(3) HMDB Compounds for PRKX Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cyclic AMP
  • Cyclic AMP
60-92-4

(1) Novoseek inferred chemical compound relationships for PRKX Gene

Compound -log(P) Hits PubMed IDs
serine 13.8 1
genes like me logo Genes that share compounds with PRKX: view

Transcripts for PRKX Gene

Unigene Clusters for PRKX Gene

Protein kinase, X-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKX Gene

No ASD Table

Relevant External Links for PRKX Gene

GeneLoc Exon Structure for
PRKX
ECgene alternative splicing isoforms for
PRKX

Expression for PRKX Gene

mRNA expression in normal human tissues for PRKX Gene

mRNA differential expression in normal tissues according to GTEx for PRKX Gene

This gene is overexpressed in Thyroid (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKX Gene

SOURCE GeneReport for Unigene cluster for PRKX Gene Hs.390788

mRNA Expression by UniProt/SwissProt for PRKX Gene

P51817-PRKX_HUMAN
Tissue specificity: Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.
genes like me logo Genes that share expressions with PRKX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRKX Gene

Orthologs for PRKX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
PRKX 35
  • 95.9 (n)
  • 93.02 (a)
PRKX 36
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRKX 35
  • 83.22 (n)
  • 86.27 (a)
PRKX 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKX 35
  • 86.45 (n)
  • 91.48 (a)
PRKX 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkx 35
  • 74.93 (n)
  • 78.31 (a)
Prkx 16
Prkx 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKX 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKX 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkx 35
  • 75.4 (n)
  • 80.72 (a)
chicken
(Gallus gallus)
Aves PRKX 35
  • 76.32 (n)
  • 89.47 (a)
PRKX 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKX 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkx 35
  • 70.49 (n)
  • 81.23 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC561941 35
  • 68.12 (n)
  • 76.52 (a)
prkx 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011840 35
  • 63.83 (n)
  • 63.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pka-C3 35
  • 62.12 (n)
  • 62.54 (a)
Pka-C3 36
  • 35 (a)
OneToOne
CG12069 37
  • 41 (a)
Pka-C3 37
  • 62 (a)
Pka-C2 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea F47F2.1 35
  • 52.94 (n)
  • 50.94 (a)
F47F2.1 36
  • 40 (a)
OneToOne
F47F2.1a 37
  • 53 (a)
F47F2.1b 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK1 36
  • 39 (a)
ManyToMany
TPK2 36
  • 42 (a)
ManyToMany
TPK3 36
  • 38 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.1519 35
wheat
(Triticum aestivum)
Liliopsida Ta.9503 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3024 36
  • 68 (a)
OneToOne
Species with no ortholog for PRKX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRKX Gene

ENSEMBL:
Gene Tree for PRKX (if available)
TreeFam:
Gene Tree for PRKX (if available)

Paralogs for PRKX Gene

Paralogs for PRKX Gene

Pseudogenes.org Pseudogenes for PRKX Gene

genes like me logo Genes that share paralogs with PRKX: view

Variants for PRKX Gene

Sequence variations from dbSNP and Humsavar for PRKX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs741422 -- 3,700,091(+) CAAAA(A/C)ACCAA intron-variant
rs741423 -- 3,633,424(-) ACTGT(A/G)CCTGG intron-variant
rs741424 -- 3,633,414(-) GCTAA(G/T)TTTTT intron-variant
rs875487 -- 3,635,040(-) aaaaa(A/G)atgtg intron-variant
rs929680 -- 3,679,211(-) GAGGG(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKX Gene

Variant ID Type Subtype PubMed ID
nsv6780 CNV Insertion 18451855
nsv508749 CNV Insertion 20534489
esv2739903 CNV Deletion 23290073
dgv1393e199 CNV Deletion 23128226
esv2739904 CNV Deletion 23290073
esv2739905 CNV Deletion 23290073
esv1734793 CNV Deletion 17803354
nsv425475 CNV Loss 16902084
esv2672795 CNV Deletion 23128226

Relevant External Links for PRKX Gene

HapMap Linkage Disequilibrium report
PRKX
Locus Specific Mutation Databases (LSDB)
PRKX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKX Gene

Disorders for PRKX Gene

UniProtKB/Swiss-Prot

PRKX_HUMAN
  • Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

(1) University of Copenhagen DISEASES for PRKX Gene

Relevant External Links for PRKX

Genetic Association Database (GAD)
PRKX
Human Genome Epidemiology (HuGE) Navigator
PRKX
genes like me logo Genes that share disorders with PRKX: view

Publications for PRKX Gene

  1. A lineage-specific protein kinase crucial for myeloid maturation. (PMID: 9860982) Semizarov D. … Huberman E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  2. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PMID: 9302280) Schiebel K. … Rappold G.A. (Hum. Mol. Genet. 1997) 3 4 23
  3. Profiles of PrKX expression in developmental mouse embryo and human tissues. (PMID: 15879576) Li W. … Kotin R.M. (J. Histochem. Cytochem. 2005) 3 4 23
  4. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PMID: 16491121) Glesne D. … Huberman E. (Oncogene 2006) 3 4 23
  5. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. (PMID: 17980165) Li X. … Wilson P.D. (Biochim. Biophys. Acta 2008) 3 4 23

Products for PRKX Gene

  • Addgene plasmids for PRKX

Sources for PRKX Gene

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