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PRKX Gene

protein-coding   GIFtS: 65
GCID: GC0XM003515

Protein Kinase, X-Linked

  Search for PRKX
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, X-Linked1 2     PKX12 3
Protein Kinase PKX12 3     CAMP-Dependent Protein Kinase Catalytic Subunit PRKX2
Protein Kinase X2 3     EC 2.7.11.13
Protein Kinase X-Linked2 3     PrKX3
Serine/Threonine-Protein Kinase PRKX2 3     EC 2.7.118

External Ids:    HGNC: 94411   Entrez Gene: 56132   Ensembl: ENSG000001839437   OMIM: 3000835   UniProtKB: P518173   

Export aliases for PRKX gene to outside databases

Previous GC identifers: GC0XU990189 GC0XM003052 GC0XM003117 GC0XM001474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKX Gene:
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP
dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal
epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal
recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal
disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. (provided by
RefSeq, Feb 2010)

GeneCards Summary for PRKX Gene:
PRKX (protein kinase, X-linked) is a protein-coding gene. GO annotations related to this gene include cAMP-dependent protein kinase activity and identical protein binding. An important paralog of this gene is PRKACG.

UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through
phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in
cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6
phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also
involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like
structure formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKX gene promoter:
         C/EBPbeta   POU2F1   POU2F1a   MRF-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKX promoter sequence
   Search Chromatin IP Primers for PRKX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3

PRKX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM003515:  view genomic region     (about GC identifiers)

Start:
3,522,384 bp from pter      End:
3,631,675 bp from pter
Size:
109,292 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit PRKX  
Size: 358 amino acids; 40896 Da
Subunit: Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX
catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the
regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does
not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein
kinase inhibitor/PKI proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1;
involved in differentiation and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain)
Developmental stage: Expression is developmentally regulated being high and specific in a wide range of developing
tissues including liver, kidney, brain and pancreas (at protein level)

Explore the universe of human proteins at neXtProt for PRKX: NX_P51817

Explore proteomics data for PRKX at MOPED

Post-translational modifications: 

  • Phosphorylated; autophosphorylates in vitro1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKX (P51817) (see all 8)
     GHIKLTD  IKLTDFG  TDFGFAK  LGILIFE 


    See PRKX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005035.1  
    ENSEMBL proteins: 
     ENSP00000262848  

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    Search eBioscience for ELISAs for PRKX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, X-linked
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P51817

    ProtoNet protein and cluster: P51817

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRKX_HUMAN, P51817
    Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through
    phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in
    cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6
    phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also
    involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like
    structure formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the
    holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates
    Biophysicochemical properties: Kinetic parameters: KM=127 uM for ATP (in the presence of 10 mM magnesium
    chloride); KM=58 uM for kemptide (in the presence of 10 mM magnesium chloride); KM=6.7 uM for kemptide (in the
    presence of 1 uM Br-cAMP at 30 degrees Celsius);
    Induction: Up-regulated by phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for PRKX:
    serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity IDA10026146
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16491121
         
    Find genes that share ontologies with PRKX           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRKX:
     Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c  High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKX
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKX

    miRNA
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    miRTarBase miRNAs that target PRKX:
    hsa-mir-375 (MIRT019867)

    Block miRNA regulation of human, mouse, rat PRKX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKX (see all 18):
    hsa-miR-520d-5p hsa-miR-128 hsa-miR-340 hsa-miR-3658 hsa-miR-365 hsa-miR-3163 hsa-miR-203 hsa-miR-4289
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKX

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PRKX (NM_005044)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKX
    Addgene plasmids for PRKX 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRKX_HUMAN, P51817: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA10026146

    Find genes that share ontologies with PRKX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKX About   (see all 35)  
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    Glutamatergic synapse0.39
    Morphine addiction0.53
    Dopaminergic synapse0.37
    Retrograde endocannabinoid signaling0.51
    Cholinergic synapse0.37
    Circadian entrainment0.40
    Serotonergic synapse0.33
    2Development Endothelin 1 EDNRA signaling
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    Inflammatory mediator regulation of TRP channels0.37
    3Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    4Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    5Oocyte meiosis
    Oocyte meiosis0.35
    Progesterone-mediated oocyte maturation0.35


    Find genes that share SuperPaths with PRKX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PRKX
        Breast Cancer Regulation by Stathmin1


    Selected Kegg Pathways  (Kegg details for PRKX) (see all 49):
        MAPK signaling pathway
    Ras signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRKX
    Interactions:

        GeneGlobe Interaction Network for PRKX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKX (P518171, 3 ENSP000002628484) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106441, 3, ENSP000003514104EBI-4302903,EBI-476431 I2D: score=2 STRING: ENSP00000351410
    PKIAP619253, ENSP000003365524I2D: score=1 STRING: ENSP00000336552
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    SMAD6O435411, ENSP000002888404EBI-4302903,EBI-976374 STRING: ENSP00000288840
    GPKOWQ929171, ENSP000001561094EBI-4302903,EBI-746309 STRING: ENSP00000156109
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IMP--
    GO:0001935endothelial cell proliferation IMP--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IMP--
    GO:0018105peptidyl-serine phosphorylation IDA16491121

    Find genes that share ontologies with PRKX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRKX

    3 HMDB Compounds for PRKX    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 Novoseek inferred chemical compound relationship for PRKX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 13.8 2 16236808 (1)



    Find genes that share compounds with PRKX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKX gene: 
    NM_005044.4  

    Unigene Cluster for PRKX:

    Protein kinase, X-linked
    Hs.390788  [show with all ESTs]
    Unigene Representative Sequence: NM_005044
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262848(uc010nde.3) ENST00000462736 ENST00000496648 ENST00000425240

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    Selected qRT-PCR Assays for microRNAs that regulate PRKX (see all 18):
    hsa-miR-520d-5p hsa-miR-128 hsa-miR-340 hsa-miR-3658 hsa-miR-365 hsa-miR-3163 hsa-miR-203 hsa-miR-4289
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      QuantiTect SYBR Green Assays in human, mouse, rat PRKX
      QuantiFast Probe-based Assays in human, mouse, rat PRKX

    Additional mRNA sequence: 

    BC041073.1 X85545.1 

    10 DOTS entries:

    DT.425806  DT.100814971  DT.92432424  DT.95273053  DT.100018653  DT.121277288  DT.95214774  DT.121277272 
    DT.121277273  DT.95153312 

    Selected AceView cDNA sequences (see all 147):

    BQ063752 AL703053 BQ016230 BQ439473 BE796887 AI122707 AI494019 BQ064171 
    BM475640 AW262234 BM827839 BM676286 BE206747 BF195252 AA565134 CA412141 
    BM894360 BC041073 AW271821 AL702968 BQ430942 AI167144 AI417286 CB529197 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTCGGG
    PRKX Expression
    About this image

    PRKX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390788

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
    Tissue specificity: Widely expressed (at protein level). Specifically expressed in blood by macrophages and
    granulocytes according to PubMed:9860982

        Custom PCR Arrays for PRKX
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    QuantiFast Probe-based Assays in human, mouse, rat PRKX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKX gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkx1 , 5 protein kinase, X-linked1, 5 74.93(n)1
    78.31(a)1
      X (38.32 cM)5
    191081  NM_016979.11  NP_058675.11 
     777614115 
    chicken
    (Gallus gallus)
    Aves PRKX1 protein kinase, X-linked 76.32(n)
    89.47(a)
      418656  XM_416852.4  XP_416852.4 
    lizard
    (Anolis carolinensis)
    Reptilia PRKX6
    protein kinase, X-linked
    82(a)
    1 ↔ 1
    3(114404963-114482015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkx1 protein kinase, X-linked 70.49(n)
    81.23(a)
      100494406  XM_002940999.2  XP_002941045.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5619411 cAMP-dependent protein kinase catalytic subunit PRKX-like 68.12(n)
    76.52(a)
      561941  XM_685338.3  XP_690430.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-C31 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    cAMP-dependent protein kinase 31
    62(a)
    (best of 3)3
    62.12(n)1
    62.54(a)1
      397331  NM_168638.31  NP_730083.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F47F2.1a3
    F47F2.11
    protein kinase3
    F47F2.11
    53(a)
    (best of 2)3
    52.94(n)1
    50.94(a)1
      X(3926462-3928330)3
    1806731  NM_076270.31  NP_508671.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK26
    TPK16
    (see all 3)
    cAMP-dependent protein kinase catalytic subunit; p...
    cAMP-dependent protein kinase catalytic subunit; p...
    (see all 3)
    42(a)
    39(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XVI(166256-167398) YPL203W
    X(109966-111159) YJL164C
    corn
    (Zea mays)
    Liliopsida Zm.15192 Zea mays nonphototropic hypocotyl 1 (nph1) mRNA, complete more 72.69(n)    AF033263.1 


    ENSEMBL Gene Tree for PRKX (if available)
    TreeFam Gene Tree for PRKX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKX gene
    PRKACG2  PRKG22  PRKACA2  PRKG12  PRKACB2  
    Selected SIMAP similar genes for PRKX using alignment to 1 protein entry:     PRKX_HUMAN(see all similar genes):
    PRKY    PRKACB    PRKACA    KIN27    PRKACG    PRKG1
    PRKG2    RPS6KA2    RPS6KA3    AKT3    PKN2    ROCK2
    RPS6KA4    RPS6KA5    ROCK1    RPS6KA1    RPS6KB1    CAMK1

    Find genes that share paralogs with PRKX           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PRKX
    PGOHUM00000246940 PGOHUM00000238253 PGOHUM00000258447


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKX (see all 2366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385175851,2
    Cuntested13507562(+) TCTGCG/AGAACA 2 /P /L mis11Minor allele frequency- A:0.00NA 4508
    rs1469943631,2
    C--3495615(+) CACAGC/TCATGC 1 -- ds50010--------
    rs1380125821,2
    --3495670(+) TTTTAA/GGAGTC 1 -- ds50010--------
    rs1828442291,2
    --3495776(+) GCCTCA/CTGAGC 1 -- ds50010--------
    rs1123661471,2
    C,F--3495836(+) GAGATA/CGGGTC 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs125591931,2
    C,F,A,H--3495849(+) gctacG/Attgca 1 -- ds50011Minor allele frequency- A:0.25NA 8
    rs65675681,2
    C,H--3495864(+) GGTCTC/GAAACT 1 -- ds50017Minor allele frequency- G:0.00WA NA CSA 17
    rs1419852821,2
    --3495902(+) GGTCTC/TCCAAA 1 -- ds50010--------
    rs1864756461,2
    --3495935(+) CCTCCA/GTGCCT 1 -- ds50010--------
    rs78788491,2
    C--3495992(+) ccacaA/Gtgcag 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRKX (3522384 - 3631675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRKX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739903CNV Deletion23290073
    esv2739905CNV Deletion23290073
    esv1734793CNV Deletion17803354
    esv2739904CNV Deletion23290073
    esv2672795CNV Deletion23128226
    dgv1393e199CNV Deletion23128226
    nsv508749CNV Insertion20534489
    nsv6780CNV Insertion18451855
    nsv425475CNV Loss16902084

    Locus Specific Mutation Databases (LSDB): PRKX

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKX
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300083    OMIM disorders: --

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
  • Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation
    t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex
    reversal disorder in XX males and XY females

  • 1 disease from the University of Copenhagen DISEASES database for PRKX:
    FG syndrome

    Find genes that share disorders with PRKX           About GenesLikeMe

    Genetic Association Database (GAD): PRKX
    Human Genome Epidemiology (HuGE) Navigator: PRKX (1 document)

    Export disorders for PRKX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKX gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PRKX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. (PubMed id 7633447)1, 2, 3 Klink A.... Rappold G. (Hum. Mol. Genet. 1995)
    2. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. (PubMed id 17980165)1, 2, 9 Li X.... Wilson P.D. (Biochim. Biophys. Acta 2008)
    3. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PubMed id 9302280)1, 2, 9 Schiebel K.... Rappold G.A. (Hum. Mol. Genet. 1997)
    4. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PubMed id 16491121)1, 2, 9 Glesne D. and Huberman E. (Oncogene 2006)
    5. Profiles of PrKX expression in developmental mouse embryo and human tissues. (PubMed id 15879576)1, 2, 9 Li W.... Kotin R.M. (J. Histochem. Cytochem. 2005)
    6. A lineage-specific protein kinase crucial for myeloid maturation. (PubMed id 9860982)1, 2, 9 Semizarov D.... Huberman E. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. (PubMed id 21684272)1, 2 Li X.... Wilson P.D. (Dev. Biol. 2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. (PubMed id 12082174)1, 2 Li X.... Burrow C.R. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. (PubMed id 10026146)1, 2 Zimmermann B.... Herberg F.W. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5613 HGNC: 9441 AceView: PRKX Ensembl:ENSG00000183943 euGenes: HUgn5613
    ECgene: PRKX Kegg: 5613 H-InvDB: PRKX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKX gene:
    Search GeneIP for patents involving PRKX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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