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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKX Gene

protein-coding   GIFtS: 62
GCID: GC0XM003515

protein kinase, X-linked
 Explore 10 diseases affiliated with
PRKX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKX    

Aliases
for PRKX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase, X-Linked1 2     Serine/Threonine-Protein Kinase PRKX2 3
PKX11 2 3     CAMP-Dependent Protein Kinase Catalytic Subunit PRKX2
Protein Kinase PKX12 3     EC 2.7.11.13
Protein Kinase X2 3     PrKX3
Protein Kinase X-Linked2 3     EC 2.7.118

External Ids:    HGNC: 94411   Entrez Gene: 56132   Ensembl: ENSG000001839437   OMIM: 3000835   UniProtKB: P518173   

Export aliases for PRKX gene to outside databases

Previous GC identifers: GC0XU990189 GC0XM003052 GC0XM003117 GC0XM001474


Summaries
for PRKX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKX:
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP
dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial
morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination
between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males
and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. (provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through
phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular
differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation.
Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in
angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation




Genomic Views
for PRKX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKX gene promoter:
         C/EBPbeta   POU2F1   POU2F1a   MRF-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKX promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3

PRKX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM003515:  view genomic region     (about GC identifiers)

Start:
 3,522,384 bp from pter      End:
 3,631,675 bp from pter
Size:
 109,292 bases      Orientation:
 minus strand

Proteins
for PRKX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit PRKX  
Size: 358 amino acids; 40896 Da
Subunit: Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic
subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits
PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2
other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein kinase inhibitor/PKI
proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1; involved in differentiation
and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain)
Subcellular location: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation
Developmental stage: Expression is developmentally regulated being high and specific in a wide range of developing
tissues including liver, kidney, brain and pancreas (at protein level)

Explore the universe of human proteins at neXtProt for PRKX: NX_P51817

Post-translational modifications:

  • Phosphorylated; autophosphorylates in vitro1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51817

    • 4/8 DME Specific Peptides for PRKX (P51817) (see all 8)
     GHIKLTD  IKLTDFG  TDFGFAK  LGILIFE 

    PRKX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005035.1  
    ENSEMBL proteins: 
     ENSP00000262848  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PRKX Protein
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    Novus Biologicals PRKX Proteins
    Novus Biologicals PRKX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRKX

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--


    PRKX for ontologies           About GeneDecksing



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    Uscn Antibodies for PRKX
    ThermoFisher Antibodies for PRKX

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    Uscn ELISAs and CLIAs for PRKX

    Protein Domains /
    Families
    for PRKX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKX for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P51817

    ProtoNet protein and cluster: P51817

    1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Function
    for PRKX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
    Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through
    phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular
    differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation.
    Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in
    angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme
    heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates
    Biophysicochemical properties: Kinetic parameters: KM=127 uM for ATP (in the presence of 10 mM magnesium chloride);
    KM=58 uM for kemptide (in the presence of 10 mM magnesium chloride); KM=6.7 uM for kemptide (in the presence of 1 uM
    Br-cAMP at 30 degrees Celsius);
    Induction: Up-regulated by phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for PRKX:
    serine/threonine protein kinase,cAMP dependent,homologous to Drosophila DC2 kinase

    Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKX
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKX (see all 18):
    hsa-miR-520d-5p hsa-miR-128 hsa-miR-340 hsa-miR-3658 hsa-miR-365 hsa-miR-3163 hsa-miR-203 hsa-miR-4289
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKX (see all 7)
    OriGene shRNA RFP: PRKX
    OriGene siRNA: PRKX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKX

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKX (see all 3)
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    GenScript: all cDNA clones in your preferred vector: PRKX (NM_005044)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKX 

    Cell Line
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    Search LifeMap BioReagents cell lines for PRKX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKX

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004691cAMP-dependent protein kinase activity IDA17980165
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0042802identical protein binding IPI16491121


    PRKX for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PRKX:
     Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c  High actin ratio cells 


    Pathways & Interactions
    for PRKX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Gastric acid secretion
    		Gastric acid secretion1.00
    		Salivary secretion0.35
    2GnRH signaling pathway
    		GnRH signaling pathway1.00
    		Vascular smooth muscle contraction0.36
    3Oocyte meiosis
    		Oocyte meiosis1.00
    		Progesterone-mediated oocyte maturation0.35
    4Basal cell carcinoma
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    5Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PRKX
        Breast Cancer Regulation by Stathmin1


    5/27         Kegg Pathways  (Kegg details for PRKX) (see all 27):
        MAPK signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Apoptosis


    PRKX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for PRKX (P518171, 3 ENSP000002628484) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106441, 3, ENSP000003514104EBI-4302903,EBI-476431 I2D: score=2 STRING: ENSP00000351410
    PKIAP619253, ENSP000003365524I2D: score=1 STRING: ENSP00000336552
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    SMAD6O435411, ENSP000002888404EBI-4302903,EBI-976374 STRING: ENSP00000288840
    GPKOWQ929171, ENSP000001561094EBI-4302903,EBI-2561229 STRING: ENSP00000156109
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IMP--
    GO:0001935endothelial cell proliferation IMP--
    GO:0007155cell adhesion IMP--
    GO:0018105peptidyl-serine phosphorylation IDA16491121
    GO:0030099myeloid cell differentiation IDA9860982


    PRKX for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRKX

    3 HMDB Compounds for PRKX    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    1 Novoseek chemical compound relationship for PRKX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 13.8 2 16236808 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKX 

    Transcripts
    for PRKX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKX gene: 
    NM_005044.4  

    Unigene Cluster for PRKX:

    Protein kinase, X-linked
    Hs.390788  [show with all ESTs]
    Unigene Representative Sequence: NM_005044
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262848(uc010nde.3) ENST00000462736 ENST00000496648 ENST00000425240


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKX
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKX (see all 18):
    hsa-miR-520d-5p hsa-miR-128 hsa-miR-340 hsa-miR-3658 hsa-miR-365 hsa-miR-3163 hsa-miR-203 hsa-miR-4289
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKX (see all 7)
    OriGene shRNA RFP: PRKX
    OriGene siRNA: PRKX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKX
    Clone
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    GenScript: all cDNA clones in your preferred vector: PRKX (NM_005044)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKX

    Additional cDNA sequence: 

    BC041073.1 X85545.1 

    10 DOTS entries:

    DT.425806  DT.100814971  DT.92432424  DT.95273053  DT.100018653  DT.121277288  DT.95214774  DT.121277272 
    DT.121277273  DT.95153312 

    24/147 AceView cDNA sequences (see all 147):

    AI167144 AI494019 BQ064171 BQ439473 BQ016230 BE796887 AW262234 BM894360 
    BM475640 BE206747 AW271821 BF195252 BQ063752 AL703053 AI122707 T91539 
    AI590062 BU509052 CD722724 CB529197 BQ066313 AI087059 BE870819 BQ011623 

    GeneLoc Exon Structure


    Expression
    for PRKX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGGTCGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKX

    SOURCE GeneReport for Unigene cluster: Hs.390788

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
    Tissue specificity: Widely expressed (at protein level). Specifically expressed in blood by macrophages and
    granulocytes according to PubMed:9860982

        SABiosciences Custom PCR Arrays for PRKX
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKX

    Orthologs
    for PRKX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKX gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRKX1 protein kinase, X-linked 73.3(n)
    83.24(a)    		   418656  XM_416852.3  XP_416852.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PRKX6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(114409753-114444094)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5619411 serine/threonine-protein kinase PRKX-like 68.12(n)
    76.52(a)    		   561941  XM_685338.2  XP_690430.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pka-C31 , 3 protein amino acid phosphorylation protein
    serine/threonine more3
    cAMP-dependent protein kinase 31    		 62(a)
    (best of 3)3
    62.12(n)1
    62.54(a)1    		   397331  NM_079373.21  NP_524097.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea F47F2.1a3
    F47F2.11    		 protein kinase3
    Protein F47F2.11    		 53(a)
    (best of 2)3
    52.94(n)1
    50.94(a)1    		   X(3926462-3928330)3
    1806731  NM_076270.21  NP_508671.21 
    corn
    (Zea mays)    		 Liliopsida Zm.15192 Zea mays nonphototropic hypocotyl 1 (nph1) mRNA, complete more 72.69(n)    AF033263.1 


    ENSEMBL Gene Tree for PRKX (if available)
    TreeFam Gene Tree for PRKX (if available) 

    Paralogs
    for PRKX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKX gene
    PRKACG2  PRKG22  PRKACA2  PRKG12  PRKACB2  
    18/85 SIMAP similar genes for PRKX using alignment to 1 protein entry:     PRKX_HUMAN(see all similar genes):
    PRKY    PRKACB    PRKACA    KIN27    PRKACG    PRKG1
    PRKG2    RPS6KA2    RPS6KA3    AKT3    PKN2    ROCK2
    RPS6KA4    RPS6KA5    ROCK1    RPS6KA1    RPS6KB1    CAMK1

    PRKX for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PRKX
    PGOHUM00000246940 PGOHUM00000238253 PGOHUM00000258447


    Genomic Variants
    for PRKX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1993 NCBI SNPs in PRKX are shown (see all 1993)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1469943631,2
    		--3521923(+) CACAGC/TCATGC 1 -- ds50010--------
    rs1380125821,2
    		--3521978(+) TTTTAA/GGAGTC 1 -- ds50010--------
    rs1828442291,2
    		--3522084(+) GCCTCA/CTGAGC 1 -- ds50010--------
    rs1123661471,2
    		C,--3522144(+) GAGATA/CGGGTC 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs125591931,2
    		C,F,A,H,--3522157(+) gctacG/Attgca 1 -- ds50011Minor allele frequency- A:0.25NA 8
    rs65675681,2
    		C,H,--3522172(+) GGTCTC/GAAACT 1 -- ds50017Minor allele frequency- G:0.00WA NA CSA 17
    rs1419852821,2
    		--3522210(+) GGTCTC/TCCAAA 1 -- ds50010--------
    rs1864756461,2
    		--3522243(+) CCTCCA/GTGCCT 1 -- ds50010--------
    rs78788491,2
    		C,--3522300(+) ccacaA/Gtgcag 1 -- ds50010--------
    rs1913248311,2
    		--3522336(+) AGATAA/GTTGCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRKX (3522384 - 3631675 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PRKX: --
    Locus Specific Mutation Databases (LSDB): PRKX

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKX
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKX

    Disorders / Diseases
    for PRKX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKX for disorders           About GeneDecksing

    OMIM gene information: 300083    OMIM disorders: --

    UniProtKB/Swiss-Prot: PRKX_HUMAN, P51817
  • Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation
    • t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex
    reversal disorder in XX males and XY females

    10 diseases for PRKX:    About MalaCards
    sex reversal    leber hereditary optic neuropathy    fg syndrome    polycystic kidney disease
    prion disease    kidney disease    cholera    neuropathy
    malaria    breast cancer

    1 disease from the University of Copenhagen DISEASES database for PRKX:
    FG syndrome
    Human Genome Epidemiology (HuGE) Navigator: PRKX (1 document)

    Export disorders for PRKX gene to outside databases

    Publications
    for PRKX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKX gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PRKX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. (PubMed id 7633447)1, 2, 3 Klink A.... Rappold G. (1995)
    2. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. (PubMed id 17980165)1, 2, 9 Li X....Wilson P.D. (2008)
    3. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. (PubMed id 9302280)1, 2, 9 Schiebel K.... Rappold G.A. (1997)
    4. Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. (PubMed id 16491121)1, 2, 9 Glesne D. and Huberman E. (2006)
    5. Profiles of PrKX expression in developmental mouse embryo and human tissues. (PubMed id 15879576)1, 2, 9 Li W....Kotin R.M. (2005)
    6. A lineage-specific protein kinase crucial for myeloid maturation. (PubMed id 9860982)1, 2, 9 Semizarov D....Huberman E. (1998)
    7. PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. (PubMed id 21684272)1, 2 Li X.... Wilson P.D. (2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. (PubMed id 12082174)1, 2 Li X....Burrow C.R. (2002)
    10. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. (PubMed id 10026146)1, 2 Zimmermann B....Herberg F.W. (1999)

    External Searches for PRKX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5613 HGNC: 9441 AceView: PRKX Ensembl:ENSG00000183943 euGenes: HUgn5613
    ECgene: PRKX Kegg: 5613 H-InvDB: PRKX

    Other Databases showing PRKX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRKX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKX gene:
    Search GeneIP for patents involving PRKX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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