Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKRIR Gene

protein-coding   GIFtS: 51
GCID: GC11M076061

protein-kinase, interferon-inducible double stranded RNA...
 Explore 6 diseases affiliated with
PRKRIR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKRIR    

Aliases
for PRKRIR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent
Inhibitor, Repressor Of (P58 Repressor)1 2
     P58IPK-Interacting Protein2 3
DAP41 2 3     THAP Domain-Containing Protein 02 3
P52rIPK1 2     52 KDa Repressor Of The Inhibitor Of The Protein Kinase2
THAP121 2     Inhibitor Of Protein Kinase PKR2
Death-Associated Protein 42 3     THAP Domain Containing 122
58 KDa Interferon-Induced Protein Kinase-Interacting Protein2 3     P52RIPK3
THAP02 3     P52rIPK1 2

External Ids:    HGNC: 94401   Entrez Gene: 56122   Ensembl: ENSG000001374927   OMIM: 6073745   UniProtKB: O434223   

Export aliases for PRKRIR gene to outside databases

Previous GC identifers: GC11M078387 GC11M077600 GC11M076283 GC11M075787 GC11M075738 GC11M072358


Summaries
for PRKRIR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: P52K_HUMAN, O43422
Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the
PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

Gene Wiki entry for PRKRIR


Genomic Views
for PRKRIR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKRIR gene promoter:
         oct-B2   Pax-2   MyoD   Pax-2a   POU3F2   GATA-2   RORalpha1   POU2F1   Pax-2b   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKRIR promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKRIR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKRIR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

PRKRIR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKRIR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M076061:  view genomic region     (about GC identifiers)

Start:
 76,061,000 bp from pter      End:
 76,092,015 bp from pter
Size:
 31,016 bases      Orientation:
 minus strand

Proteins
for PRKRIR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P52K_HUMAN, O43422 (See protein sequence)
Recommended Name: 52 kDa repressor of the inhibitor of the protein kinase  
Size: 761 amino acids; 87704 Da
Subunit: Interacts with P58IPK, probably sequestring it
Sequence caution: Sequence=AAH21992.1; Type=Erroneous initiation; Sequence=CAB43226.1; Type=Frameshift; Positions=471;
Secondary accessions: A8K728 Q17RY9 Q8WTW1 Q9Y3Z4
Alternative splicing: 2 isoforms:  O43422-1   O43422-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKRIR: NX_O43422

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43422

    • PRKRIR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004696.2  
    ENSEMBL proteins: 
     ENSP00000436249   ENSP00000260045   ENSP00000433966  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PRKRIR
    OriGene Protein Over-expression Lysate: PRKRIR
    OriGene Custom Protein Services for PRKRIR 
    GenScript Custom Purified and Recombinant Proteins Services for PRKRIR
    Novus Biologicals PRKRIR Protein
    Novus Biologicals PRKRIR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRKRIR

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    PRKRIR for ontologies           About GeneDecksing



    PRKRIR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRKRIR 
    GenScript Custom Superior Antibodies Services for PRKRIR
    Novus Biologicals PRKRIR Antibodies
    Search for Antibodies for PRKRIR at Abcam  
    Uscn Antibodies for PRKRIR
    Search ThermoFisher Antibodies for PRKRIR

    Assay Products for PRKRIR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKRIR
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRKRIR

    Protein Domains /
    Families
    for PRKRIR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKRIR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR025398 DUF4371
     IPR006612 Znf_C2CH
     IPR008906 HATC
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry O43422

    ProtoNet protein and cluster: O43422

    1 Blocks protein family: IPB008906 HAT dimerisation

    UniProtKB/Swiss-Prot: P52K_HUMAN, O43422
    Similarity: Contains 1 THAP-type zinc finger


    Function
    for PRKRIR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P52K_HUMAN, O43422
    Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the
    PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

         Genatlas biochemistry entry for PRKRIR:
    protein kinase,interferon-induciblen,double stranded RNA dependent inhibitor,repressor of (P58 repressor),widely
    expressed,with homology to HSP (90kDa)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PRKRIR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKRIR
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKRIR (see all 24):
    hsa-miR-30c hsa-miR-34b* hsa-miR-300 hsa-miR-30d hsa-miR-30a hsa-miR-23a hsa-miR-3662 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: PRKRIR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKRIR (see all 4)
    OriGene shRNA RFP: PRKRIR
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKRIR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKRIR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRKRIR (NM_004705)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKRIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKRIR 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRKRIR
    Search LifeMap BioReagents cell lines for PRKRIR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIR

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0016301kinase activity ----
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--


    PRKRIR for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PRKRIR:
     Increased viability with TRAIL 


    Pathways & Interactions
    for PRKRIR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKRIR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for PRKRIR (O434223 ENSP000002600454) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK4Q130433, ENSP000003618924I2D: score=3 STRING: ENSP00000361892
    EIF2S1P051983, ENSP000002563834I2D: score=2 STRING: ENSP00000256383
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    DDX58O957863, ENSP000003692134I2D: score=1 STRING: ENSP00000369213
    DNAJC3Q132173, ENSP000003659914I2D: score=2 STRING: ENSP00000365991
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress TAS9447982
    GO:0007165signal transduction TAS9447982
    GO:0008285negative regulation of cell proliferation TAS9447982


    PRKRIR for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKRIR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRKRIR
    Search CenterWatch for drugs/clinical trials and news about PRKRIR / P52K 

    Transcripts
    for PRKRIR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKRIR gene: 
    NM_004705.2  

    Unigene Cluster for PRKRIR:

    Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
    Hs.503315  [show with all ESTs]
    Unigene Representative Sequence: BX641144
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529901(uc010rrz.1) ENST00000260045(uc001oxh.1) ENST00000528993
    ENST00000525277 ENST00000531878

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PRKRIR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKRIR
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKRIR (see all 24):
    hsa-miR-30c hsa-miR-34b* hsa-miR-300 hsa-miR-30d hsa-miR-30a hsa-miR-23a hsa-miR-3662 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: PRKRIR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKRIR (see all 4)
    OriGene shRNA RFP: PRKRIR
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKRIR
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRKRIR (NM_004705)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKRIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKRIR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKRIR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKRIR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKRIR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKRIR

    Additional cDNA sequence: 

    AF007393.1 AF081567.1 AK001522.1 AK291843.1 AK299594.1 AL049970.1 BC021992.1 BC110304.1 
    BC117138.1 BC117140.1 BX641144.1 

    9 DOTS entries:

    DT.418095  DT.99970844  DT.91765613  DT.97762969  DT.100722887  DT.100722209  DT.120687021  DT.95244789 
    DT.99931245 

    24/209 AceView cDNA sequences (see all 209):

    AA761126 AA768360 AI619506 BQ889280 BI254561 BQ084027 AA076164 BX404381 
    CK429512 H73483 BG577430 AI691035 NM_004705 AA328319 BQ575253 AI219805 
    AI680571 AA298166 AA457452 AA195716 BX641144 BE886885 CB122830 AI826803 

    GeneLoc Exon Structure


    Expression
    for PRKRIR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKRIR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCTTATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKRIR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKRIR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKRIR

    SOURCE GeneReport for Unigene cluster: Hs.503315
        SABiosciences Custom PCR Arrays for PRKRIR
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKRIR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKRIR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKRIR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKRIR
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIR

    Orthologs
    for PRKRIR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKRIR gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Prkrir1 , 5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) less1, 5 88.51(n)1
    95.24(a)1    		   7 (53.86 cM)5
    729811  NM_028410.11  NP_082686.11 
     987031035 
    chicken
    (Gallus gallus)    		 Aves PRKRIR1 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) less 78.73(n)
    86.18(a)    		   428122  XM_425679.3  XP_425679.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PRKRIR6
    --
    (see all 6)    		 --
    		 80(a)
    29(a)
    (see all 6)    		 1 ↔ 1
    possible ortholog
    (see all 6)    		 GL343493.1(559294-583063)
    GL343285.1(1006963-1008299)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC758602 hypothetical protein MGC75860 73.2(n)    BC061337.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.29252 Danio rerio mRNA similar to protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) (cDNA clone MGC55697 IMAGE3815821), complete cds less 73.29(n)    BC044456.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G160406
    AT3G297656
    (see all 11)    		 hAT dimerisation domain-containing protein / trans...
    General transcription factor 2-related zinc finger...
    (see all 11)    		 19(a)
    19(a)
    (see all 11)    		 1 ↔ 1
    possible ortholog
    (see all 11)    		 2(6976017-6977594)
    3(11595467-11597077)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 36)    		 conserved hypothetical protein
    hAT dimerisation domain-containing protein, putati...
    (see all 36)    		 9(a)
    8(a)
    (see all 36)    		 possible ortholog
    possible ortholog
    (see all 36)    		 4(12290950-12293602)
    9(7094651-7096308)


    ENSEMBL Gene Tree for PRKRIR (if available)
    TreeFam Gene Tree for PRKRIR (if available) 

    Paralogs
    for PRKRIR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKRIR gene
    3 SIMAP similar genes for PRKRIR using alignment to 4 protein entries:     P52K_HUMAN (see all proteins):
    DKFZP564I0422    THAP5    THAP8

    PRKRIR for paralogs           About GeneDecksing


    5/18 Pseudogenes.org Pseudogenes for PRKRIR (see all 18)
    PGOHUM00000238800 PGOHUM00000242616 PGOHUM00000242619 PGOHUM00000257939 PGOHUM00000257940


    Genomic Variants
    for PRKRIR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/512 NCBI SNPs in PRKRIR are shown (see all 512)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs49441061,2
    		H--72387407(+) ctcatC/Atcacc 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs96456951,2
    		C,H--72388199(+) TGCGAT/CGAGAT 2 -- us2k16Minor allele frequency- C:0.00NS EA NA 418
    rs770191241,2
    		F,--72388330(+) ACGCCC/GAGAGA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs787579251,2
    		--72388367(+) AGCAAA/GTGAGC 2 -- us2k10--------
    rs116074751,2
    		C,H,--72388519(+) GCTCCC/TCATCT 2 -- us2k10--------
    rs785861981,2
    		--72389216(+) CGCACA/GGTCTA 2 -- ut512Minor allele frequency- G:0.08CSA WA 120
    rs38147121,2
    		C,F,H,--72389286(-) AGCCCA/GGGAAC 2 -- ut5115Minor allele frequency- G:0.09NS EA NA WA 2218
    rs65926301,2
    		C,F,H,--76060528(+) CAGAGG/ACATCT 1 -- int131Minor allele frequency- A:0.06NS EA NA WA CSA 2758
    rs1829632601,2
    		--76060564(+) CTCTTC/GTTATC 1 -- int10--------
    rs122822321,2
    		C,F,H,--76060720(+) TCCCAA/GCATAA 1 -- int111Minor allele frequency- G:0.05NS EA NA CSA WA 1214

    HapMap Linkage Disequilibrium report for PRKRIR (76061000 - 76092015 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PRKRIR
         1 CNV: 101265

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKRIR
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKRIR

    Disorders / Diseases
    for PRKRIR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKRIR for disorders           About GeneDecksing

    OMIM gene information: 607374    OMIM disorders: --

    6 diseases for PRKRIR:    About MalaCards
    dengue hemorrhagic fever    hemorrhagic fever    gastric adenocarcinoma    ovarian cancer
    adenocarcinoma    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: PRKRIR (3 documents)

    Export disorders for PRKRIR gene to outside databases

    Publications
    for PRKRIR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKRIR gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with PRKRIR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PubMed id 9447982)1, 2, 3 Gale M.J. Jr.... Katze M.G. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. A protein-kinase, IFN-inducible double-stranded RNA d ependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated a ntiviral response through the stability control of RIG-I protein. (PubMed id 21910972)1 Now H. and Yoo J.Y. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1 Johnatty S.E.... . (2010)
    10. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1 Silva L.K....Teixeira M.G. (2010)

    External Searches for PRKRIR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKRIR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5612 HGNC: 9440 AceView: PRKRIR Ensembl:ENSG00000137492 euGenes: HUgn5612
    ECgene: PRKRIR H-InvDB: PRKRIR

    Other Databases showing PRKRIR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKRIR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKRIR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRKRIR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKRIR gene:
    Search GeneIP for patents involving PRKRIR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRKRIR gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PRKRIR  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKRIR   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKRIR  
     OriGene Protein Over-expression Lysate for PRKRIR   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for PRKRIR  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKRIR  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PRKRIR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKRIR   OriGene Custom Protein Services for PRKRIR  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKRIR
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKRIR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKRIR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKRIR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKRIR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKRIR
     GenScript Custom Purified and Recombinant Proteins Services for PRKRIR GenScript cDNA clones with any tag delivered in your preferred vector for PRKRIR
     GenScript Custom Assay Services for PRKRIR GenScript Custom Superior Antibodies Services for PRKRIR
     GenScript Custom overexpressing Cell Line Services for PRKRIR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRKRIR promoter
     Search Chromatin IP Primers for PRKRIR
     RT2 qPCR Primer Assay in human, mouse, rat PRKRIR
     GNC Network for PRKRIR
     SABiosciences Custom PCR Arrays for PRKRIR
     Search Tocris compounds for PRKRIR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRKRIR antibodies
     PRKRIR proteins
     PRKRIR lysates
     Search for Antibodies for PRKRIR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PRKRIR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PRKRIR Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PRKRIR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIR
     SwitchGear 3'UTR luciferase reporter plasmids for PRKRIR
     SwitchGear Promoter luciferase reporter plasmids for PRKRIR
     Search ThermoFisher Antibodies for PRKRIR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKRIR
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PRKRIR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4