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PRKRIR Gene

protein-coding   GIFtS: 51
GCID: GC11M076061

Protein-Kinase, Interferon-Inducible Double Stranded RNA...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent
Inhibitor, Repressor Of (P58 Repressor)1 2
     THAP Domain-Containing Protein 02 3
THAP Domain Containing 121 2     52 KDa Repressor Of The Inhibitor Of The Protein Kinase2
Death-Associated Protein 42 3     P52rIPK2
58 KDa Interferon-Induced Protein Kinase-Interacting Protein2 3     THAP122
DAP42 3     Inhibitor Of Protein Kinase PKR2
THAP02 3     P52RIPK3
P58IPK-Interacting Protein2 3     p52rIPK3

External Ids:    HGNC: 94401   Entrez Gene: 56122   Ensembl: ENSG000001374927   OMIM: 6073745   UniProtKB: O434223   

Export aliases for PRKRIR gene to outside databases

Previous GC identifers: GC11M078387 GC11M077600 GC11M076283 GC11M075787 GC11M075738 GC11M072358


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRKRIR Gene:
PRKRIR (protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)) is a protein-coding gene. Diseases associated with PRKRIR include dengue hemorrhagic fever, and gastric adenocarcinoma. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot: P52K_HUMAN, O43422
Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the
PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

Gene Wiki entry for PRKRIR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKRIR gene promoter:
         oct-B2   Pax-2   MyoD   Pax-2a   POU3F2   GATA-2   RORalpha1   POU2F1   Pax-2b   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKRIR promoter sequence
   Search Chromatin IP Primers for PRKRIR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKRIR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

PRKRIR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKRIR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M076061:  view genomic region     (about GC identifiers)

Start:
76,061,000 bp from pter      End:
76,092,015 bp from pter
Size:
31,016 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: P52K_HUMAN, O43422 (See protein sequence)
Recommended Name: 52 kDa repressor of the inhibitor of the protein kinase  
Size: 761 amino acids; 87704 Da
Subunit: Interacts with P58IPK, probably sequestring it
Sequence caution: Sequence=AAH21992.1; Type=Erroneous initiation; Sequence=CAB43226.1; Type=Frameshift;
Positions=471;
Secondary accessions: A8K728 Q17RY9 Q8WTW1 Q9Y3Z4
Alternative splicing: 2 isoforms:  O43422-1   O43422-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKRIR: NX_O43422

Explore proteomics data for PRKRIR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRKRIR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004696.2  
    ENSEMBL proteins: 
     ENSP00000260045   ENSP00000433966  

    PRKRIR Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PRKRIR

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    Cloud-Clone Corp. CLIAs for PRKRIR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THAP: THAP (C2CH-type zinc finger) domain containing

    4 InterPro protein domains:
     IPR025398 DUF4371
     IPR006612 Znf_C2CH
     IPR008906 HATC_dom_C
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry O43422

    ProtoNet protein and cluster: O43422

    1 Blocks protein domain: IPB008906 HAT dimerisation

    UniProtKB/Swiss-Prot: P52K_HUMAN, O43422
    Similarity: Contains 1 THAP-type zinc finger


    PRKRIR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P52K_HUMAN, O43422
    Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the
    PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

         Genatlas biochemistry entry for PRKRIR:
    protein kinase,interferon-induciblen,double stranded RNA dependent inhibitor,repressor of (P58 repressor),widely
    expressed,with homology to HSP (90kDa)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    PRKRIR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRKRIR:
     Increased viability with TRAIL 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKRIR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKRIR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKRIR

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKRIR:
    hsa-mir-24-3p (MIRT030578), hsa-mir-98-5p (MIRT027707), hsa-mir-7-5p (MIRT025850), hsa-mir-34a-5p (MIRT025526)

    Block miRNA regulation of human, mouse, rat PRKRIR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKRIR (see all 24):
    hsa-miR-30c hsa-miR-34b* hsa-miR-300 hsa-miR-30d hsa-miR-30a hsa-miR-23a hsa-miR-3662 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidPRKRIR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKRIR

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKRIR

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    PRKRIR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRKRIR
    Interactions:

        GeneGlobe Interaction Network for PRKRIR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for PRKRIR (O434223 ENSP000002600454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK4Q130433, ENSP000003618924I2D: score=3 STRING: ENSP00000361892
    EIF2S1P051983, ENSP000002563834I2D: score=2 STRING: ENSP00000256383
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    DDX58O957863, ENSP000003692134I2D: score=1 STRING: ENSP00000369213
    DNAJC3Q132173, ENSP000003659914I2D: score=2 STRING: ENSP00000365991
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress TAS9447982
    GO:0007165signal transduction TAS9447982
    GO:0008285negative regulation of cell proliferation TAS9447982

    PRKRIR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRKRIR (P52K)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKRIR gene: 
    NM_004705.2  

    Unigene Cluster for PRKRIR:

    Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
    Hs.503315  [show with all ESTs]
    Unigene Representative Sequence: BX641144
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529901(uc010rrz.1) ENST00000260045(uc001oxh.1) ENST00000528993
    ENST00000525277 ENST00000531878
    miRNA
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    Block miRNA regulation of human, mouse, rat PRKRIR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKRIR (see all 24):
    hsa-miR-30c hsa-miR-34b* hsa-miR-300 hsa-miR-30d hsa-miR-30a hsa-miR-23a hsa-miR-3662 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidPRKRIR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKRIR
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKRIR
    Primer
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    OriGene qPCR primer pairs and template standards for PRKRIR
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKRIR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKRIR
      QuantiTect SYBR Green Assays in human, mouse, rat PRKRIR
      QuantiFast Probe-based Assays in human, mouse, rat PRKRIR

    Additional mRNA sequence: 

    AF007393.1 AF081567.1 AK001522.1 AK291843.1 AK299594.1 AL049970.1 BC021992.1 BC110304.1 
    BC117138.1 BC117140.1 BX641144.1 

    9 DOTS entries:

    DT.418095  DT.99970844  DT.91765613  DT.97762969  DT.100722887  DT.100722209  DT.120687021  DT.95244789 
    DT.99931245 

    Selected AceView cDNA sequences (see all 209):

    AA287650 BQ889280 BI254561 AI569223 T30492 BU521171 AA768360 AW188216 
    AI826803 AA286803 AW771812 CB243455 AA173504 CB050060 BX641144 AI312945 
    AA328319 AA076164 AI219805 AA765102 NM_004705 BQ084027 AA115461 CB122830 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKRIR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTTATAT
    PRKRIR Expression
    About this image


    PRKRIR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    PRKRIR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKRIR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503315
        Custom PCR Arrays for PRKRIR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRKRIR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkrir1 , 5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) less1, 5 88.51(n)1
    95.24(a)1
      7 (53.86 cM)5
    729811  NM_028410.11  NP_082686.11 
     987031035 
    chicken
    (Gallus gallus)
    Aves PRKRIR1 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) less 78.67(n)
    86.07(a)
      428122  XM_425679.4  XP_425679.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRKRIR6
    protein-kinase, interferon-inducible double strand...
    80(a)
    1 ↔ 1
    GL343493.1(557329-586712)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC758602 hypothetical protein MGC75860 73.2(n)    BC061337.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.29252 Danio rerio mRNA similar to protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) (cDNA clone MGC55697 IMAGE3815821), complete cds less 73.29(n)    BC044456.1 


    ENSEMBL Gene Tree for PRKRIR (if available)
    TreeFam Gene Tree for PRKRIR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKRIR gene
    2 SIMAP similar genes for PRKRIR using alignment to 4 protein entries:     P52K_HUMAN (see all proteins):
    DKFZP564I0422    THAP5

    PRKRIR for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for PRKRIR (see all 18)
    PGOHUM00000238800 PGOHUM00000242616 PGOHUM00000242619 PGOHUM00000257939 PGOHUM00000257940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKRIR (see all 612)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65926301,2
    C,F,H--76060528(+) CAGAGG/ACATCT 1 -- int131Minor allele frequency- A:0.06NS EA NA WA CSA 2758
    rs1829632601,2
    --76060564(+) CTCTTC/GTTATC 1 -- int10--------
    rs122822321,2
    C,F,H--76060720(+) TCCCAA/GCATAA 1 -- int111Minor allele frequency- G:0.05NS EA NA CSA WA 1214
    rs1884569801,2
    --76060761(+) TAGCCA/GGCAAC 1 -- int10--------
    rs618928021,2
    C--76060812(+) GTACAT/ATTAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs358140301,2
    C--76060814(+) CATTT-/A/TAAAAA 1 -- int11NA 2
    rs1916948601,2
    --76060826(+) AAAAAA/GAAACC 1 -- int10--------
    rs112367271,2
    C,F--76060869(+) TAATTG/TTTTTT 1 -- int14Minor allele frequency- T:0.07NA EA 254
    rs762433221,2
    C,F--76060873(+) TGTTTT/CTTTTC 1 -- int12Minor allele frequency- C:0.03WA NA 238
    rs1411582561,2
    --76060878(+) TTTTTC/TTGTAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRKRIR (76061000 - 76092015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PRKRIR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2459110CNV Insertion19546169
    esv269316CNV Insertion20981092
    nsv521451CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKRIR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607374    OMIM disorders: --

    6 diseases for PRKRIR:    
    About MalaCards
    dengue hemorrhagic fever    gastric adenocarcinoma    hemorrhagic fever    ovarian cancer
    adenocarcinoma    pancreatitis


    PRKRIR for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKRIR
    Human Genome Epidemiology (HuGE) Navigator: PRKRIR (3 documents)

    Export disorders for PRKRIR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKRIR gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PRKRIR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PubMed id 9447982)1, 2, 3 Gale M.J. Jr.... Katze M.G. (Mol. Cell. Biol. 1998)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein. (PubMed id 21910972)1 Now H. and Yoo J.Y. (Biochem. Biophys. Res. Commun. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5612 HGNC: 9440 AceView: PRKRIR Ensembl:ENSG00000137492 euGenes: HUgn5612
    ECgene: PRKRIR H-InvDB: PRKRIR

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKRIR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKRIR gene:
    Search GeneIP for patents involving PRKRIR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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