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Aliases for PRKRIR Gene

Aliases for PRKRIR Gene

  • Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (P58 Repressor) 2 3
  • 58 KDa Interferon-Induced Protein Kinase-Interacting Protein 3 4
  • THAP Domain-Containing Protein 0 3 4
  • Death-Associated Protein 4 3 4
  • P58IPK-Interacting Protein 3 4
  • THAP Domain Containing 12 2 3
  • P52rIPK 3 4
  • THAP0 3 4
  • DAP4 3 4
  • 52 KDa Repressor Of The Inhibitor Of The Protein Kinase 3
  • Inhibitor Of Protein Kinase PKR 3
  • THAP12 3

External Ids for PRKRIR Gene

Previous GeneCards Identifiers for PRKRIR Gene

  • GC11M078387
  • GC11M077600
  • GC11M075787
  • GC11M075738
  • GC11M076061
  • GC11M072358

Summaries for PRKRIR Gene

GeneCards Summary for PRKRIR Gene

PRKRIR (Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (P58 Repressor)) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for PRKRIR Gene

  • Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

Gene Wiki entry for PRKRIR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKRIR Gene

Genomics for PRKRIR Gene

Regulatory Elements for PRKRIR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKRIR Gene

Start:
76,349,956 bp from pter
End:
76,380,971 bp from pter
Size:
31,016 bases
Orientation:
Minus strand

Genomic View for PRKRIR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKRIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKRIR Gene

Proteins for PRKRIR Gene

  • Protein details for PRKRIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43422-P52K_HUMAN
    Recommended name:
    52 kDa repressor of the inhibitor of the protein kinase
    Protein Accession:
    O43422
    Secondary Accessions:
    • A8K728
    • Q17RY9
    • Q8WTW1
    • Q9Y3Z4

    Protein attributes for PRKRIR Gene

    Size:
    761 amino acids
    Molecular mass:
    87704 Da
    Quaternary structure:
    • Interacts with P58IPK, probably sequestring it
    SequenceCaution:
    • Sequence=AAH21992.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43226.1; Type=Frameshift; Positions=471; Evidence={ECO:0000305};

    Alternative splice isoforms for PRKRIR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKRIR Gene

Proteomics data for PRKRIR Gene at MOPED

Post-translational modifications for PRKRIR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKRIR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKRIR Gene

Domains for PRKRIR Gene

Gene Families for PRKRIR Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for PRKRIR Gene

Graphical View of Domain Structure for InterPro Entry

O43422

UniProtKB/Swiss-Prot:

P52K_HUMAN :
  • O43422
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with PRKRIR: view

Function for PRKRIR Gene

Molecular function for PRKRIR Gene

GENATLAS Biochemistry: protein kinase,interferon-induciblen,double stranded RNA dependent inhibitor,repressor of (P58 repressor),widely expressed,with homology to HSP (90kDa)
UniProtKB/Swiss-Prot Function: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth

Gene Ontology (GO) - Molecular Function for PRKRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with PRKRIR: view

Phenotypes for PRKRIR Gene

GenomeRNAi human phenotypes for PRKRIR:
genes like me logo Genes that share phenotypes with PRKRIR: view

Animal Model Products

CRISPR Products

miRNA for PRKRIR Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKRIR Gene

Localization for PRKRIR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKRIR Gene COMPARTMENTS Subcellular localization image for PRKRIR gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRKRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRKRIR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKRIR Gene

Pathways for PRKRIR Gene

SuperPathways for PRKRIR Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRKRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 9447982
GO:0007165 signal transduction TAS 9447982
GO:0008285 negative regulation of cell proliferation TAS 9447982
genes like me logo Genes that share ontologies with PRKRIR: view

No data available for Pathways by source for PRKRIR Gene

Transcripts for PRKRIR Gene

mRNA/cDNA for PRKRIR Gene

Unigene Clusters for PRKRIR Gene

Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKRIR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKRIR Gene

No ASD Table

Relevant External Links for PRKRIR Gene

GeneLoc Exon Structure for
PRKRIR
ECgene alternative splicing isoforms for
PRKRIR

Expression for PRKRIR Gene

mRNA expression in normal human tissues for PRKRIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKRIR Gene

SOURCE GeneReport for Unigene cluster for PRKRIR Gene Hs.503315

genes like me logo Genes that share expressions with PRKRIR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKRIR Gene

Orthologs for PRKRIR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRKRIR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKRIR 35
  • 99.94 (n)
  • 100 (a)
PRKRIR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKRIR 35
  • 92.2 (n)
  • 96.84 (a)
PRKRIR 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKRIR 35
  • 92.25 (n)
  • 96.71 (a)
PRKRIR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkrir 35
  • 88.51 (n)
  • 95.24 (a)
Prkrir 16
Prkrir 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKRIR 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKRIR 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkrir 35
  • 88.55 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves PRKRIR 35
  • 78.67 (n)
  • 86.07 (a)
PRKRIR 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKRIR 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75860 35
prkrir 35
  • 67.26 (n)
  • 71.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12467 35
zebrafish
(Danio rerio)
Actinopterygii Dr.2925 35
PRKRIR (3 of 3) 36
  • 9 (a)
OneToMany
prkrira 36
  • 52 (a)
OneToMany
prkrirb 35
  • 61.4 (n)
  • 57.97 (a)
prkrirb 36
  • 56 (a)
OneToMany
Species with no ortholog for PRKRIR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRKRIR Gene

ENSEMBL:
Gene Tree for PRKRIR (if available)
TreeFam:
Gene Tree for PRKRIR (if available)

Paralogs for PRKRIR Gene

Selected SIMAP similar genes for PRKRIR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKRIR: view

No data available for Paralogs for PRKRIR Gene

Variants for PRKRIR Gene

Sequence variations from dbSNP and Humsavar for PRKRIR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2156713 -- 76,355,706(+) ACTGA(C/T)CTCTA intron-variant
rs2226895 -- 76,360,090(+) AACAG(C/T)TTCTC intron-variant
rs2618062 -- 76,353,073(+) TAGAG(C/G)GGGGA intron-variant
rs2618063 -- 76,354,003(+) GACTC(C/T)GTCTC intron-variant
rs2618064 -- 76,357,423(+) ATTTC(C/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKRIR Gene

Variant ID Type Subtype PubMed ID
nsv521451 CNV Loss 19592680
esv2459110 CNV Insertion 19546169
esv269316 CNV Insertion 20981092

Relevant External Links for PRKRIR Gene

HapMap Linkage Disequilibrium report
PRKRIR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKRIR Gene

Disorders for PRKRIR Gene

Relevant External Links for PRKRIR

Genetic Association Database (GAD)
PRKRIR
Human Genome Epidemiology (HuGE) Navigator
PRKRIR
genes like me logo Genes that share disorders with PRKRIR: view

No data available for UniProtKB/Swiss-Prot for PRKRIR Gene

Publications for PRKRIR Gene

  1. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PMID: 9447982) Gale M.J. Jr. … Katze M.G. (Mol. Cell. Biol. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 48
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 48

Products for PRKRIR Gene

Sources for PRKRIR Gene

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