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Aliases for PRKRIP1 Gene

Aliases for PRKRIP1 Gene

  • PRKR Interacting Protein 1 (IL11 Inducible) 2 3 5
  • Likely Ortholog Of Mouse C114 DsRNA-Binding Protein 2 3
  • KRAB Box Domain Containing 3 2 3
  • KRBOX3 3
  • C114 3

External Ids for PRKRIP1 Gene

Previous GeneCards Identifiers for PRKRIP1 Gene

  • GC07P101523
  • GC07P101597
  • GC07P101791
  • GC07P101823
  • GC07P102006
  • GC07P102008
  • GC07P096627
  • GC07P102366
  • GC07P102368

Summaries for PRKRIP1 Gene

GeneCards Summary for PRKRIP1 Gene

PRKRIP1 (PRKR Interacting Protein 1 (IL11 Inducible)) is a Protein Coding gene. Diseases associated with PRKRIP1 include Fructose-1,6-Bisphosphatase Deficiency. GO annotations related to this gene include protein kinase binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PRKRIP1 Gene

  • Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKRIP1 Gene

Genomics for PRKRIP1 Gene

Regulatory Elements for PRKRIP1 Gene

Enhancers for PRKRIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRKRIP1 on UCSC Golden Path with GeneCards custom track

Promoters for PRKRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKRIP1 Gene

102,363,872 bp from pter
102,426,682 bp from pter
62,811 bases
Plus strand

Genomic View for PRKRIP1 Gene

Genes around PRKRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKRIP1 Gene

Proteins for PRKRIP1 Gene

  • Protein details for PRKRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRKR-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DGM2
    • Q8NDM6
    • Q96CF8

    Protein attributes for PRKRIP1 Gene

    184 amino acids
    Molecular mass:
    20997 Da
    Quaternary structure:
    • Interacts with EIF2AK2.

    Alternative splice isoforms for PRKRIP1 Gene


neXtProt entry for PRKRIP1 Gene

Proteomics data for PRKRIP1 Gene at MOPED

Post-translational modifications for PRKRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKRIP1 Gene

Domains & Families for PRKRIP1 Gene

Gene Families for PRKRIP1 Gene

Protein Domains for PRKRIP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRKRIP1 family.
  • Belongs to the PRKRIP1 family.
genes like me logo Genes that share domains with PRKRIP1: view

Function for PRKRIP1 Gene

Molecular function for PRKRIP1 Gene

UniProtKB/Swiss-Prot Function:
Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

Gene Ontology (GO) - Molecular Function for PRKRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PRKRIP1: view
genes like me logo Genes that share phenotypes with PRKRIP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKRIP1 Gene

Localization for PRKRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKRIP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for PRKRIP1 Gene COMPARTMENTS Subcellular localization image for PRKRIP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PRKRIP1 Gene

Pathways & Interactions for PRKRIP1 Gene

SuperPathways for PRKRIP1 Gene

No Data Available

Interacting Proteins for PRKRIP1 Gene

Gene Ontology (GO) - Biological Process for PRKRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003014 renal system process IDA 21183621
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IEA --
genes like me logo Genes that share ontologies with PRKRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for PRKRIP1 Gene

Drugs & Compounds for PRKRIP1 Gene

No Compound Related Data Available

Transcripts for PRKRIP1 Gene

Unigene Clusters for PRKRIP1 Gene

PRKR interacting protein 1 (IL11 inducible):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKRIP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP5: - -

Relevant External Links for PRKRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKRIP1 Gene

mRNA expression in normal human tissues for PRKRIP1 Gene

Protein differential expression in normal tissues from HIPED for PRKRIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0), CD8 Tcells (7.8), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKRIP1 Gene

SOURCE GeneReport for Unigene cluster for PRKRIP1 Gene Hs.722104

genes like me logo Genes that share expression patterns with PRKRIP1: view

Protein tissue co-expression partners for PRKRIP1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKRIP1 Gene

Orthologs for PRKRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRKRIP1 35
  • 89.86 (n)
  • 90.22 (a)
  • 89 (a)
(Canis familiaris)
Mammalia PRKRIP1 35
  • 92.27 (n)
  • 97.35 (a)
  • 68 (a)
(Mus musculus)
Mammalia Prkrip1 35
  • 90.22 (n)
  • 92.39 (a)
Prkrip1 16
Prkrip1 36
  • 91 (a)
(Pan troglodytes)
Mammalia PRKRIP1 35
  • 99.46 (n)
  • 98.91 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Prkrip1 35
  • 90.04 (n)
  • 92.93 (a)
(Monodelphis domestica)
Mammalia PRKRIP1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PRKRIP1 36
  • 68 (a)
(Gallus gallus)
Aves PRKRIP1 35
  • 71.79 (n)
  • 75.82 (a)
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prkrip1 35
  • 69.43 (n)
  • 68.28 (a)
Str.20382 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23753 35
(Danio rerio)
Actinopterygii neurog3 35
prkrip1 35
  • 66.47 (n)
  • 66.47 (a)
prkrip1 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8441 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F37A4.2 36
  • 34 (a)
Species with no ortholog for PRKRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKRIP1 Gene

Gene Tree for PRKRIP1 (if available)
Gene Tree for PRKRIP1 (if available)

Paralogs for PRKRIP1 Gene

No data available for Paralogs for PRKRIP1 Gene

Variants for PRKRIP1 Gene

Sequence variations from dbSNP and Humsavar for PRKRIP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_039882 -
VAR_039883 -

Structural Variations from Database of Genomic Variants (DGV) for PRKRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv2121e1 CNV Complex 17122850
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
nsv464664 CNV Gain 19166990
nsv464665 CNV Loss 19166990

Variation tolerance for PRKRIP1 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRKRIP1 Gene

Disorders for PRKRIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRKRIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fructose-1,6-bisphosphatase deficiency
  • fructose 1 phosphate aldolase deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRKRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRKRIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKRIP1 Gene

Publications for PRKRIP1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R. (PMID: 12679338) Yin Z. … Yang Y.C. (J. Biol. Chem. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for PRKRIP1 Gene

Sources for PRKRIP1 Gene