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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKRIP1 Gene

protein-coding   GIFtS: 47
GCID: GC07P102008

PRKR interacting protein 1 (IL11 inducible)

 Explore 1 disease affiliated with
PRKRIP1 via our new
 Human Malady Compendium 
Biological research products
for PRKRIP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
PRKR Interacting Protein 1 (IL11 Inducible)1 2     KRAB Box Domain Containing 32
C1141 2     Likely Ortholog Of Mouse C114 DsRNA-Binding Protein2
KRBOX31 2     PRKR-Interacting Protein 12
FLJ139021     

External Ids:    HGNC: 218941   Entrez Gene: 797062   Ensembl: ENSG000001285637   UniProtKB: Q9H8753   
ORGUL members:         
NONCODE:n411139    

Export aliases for PRKRIP1 gene to outside databases

Previous GC identifers: GC07P101523 GC07P101597 GC07P101791 GC07P101823 GC07P102006 GC07P096627


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PKRI1_HUMAN, Q9H875
Function: Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKRIP1 gene promoter:
         Max1   ISGF-3   FOXF2   Pax-5   MZF-1   AREB6   FOXO1a   ZIC2/Zic2   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKRIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKRIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKRIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

PRKRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKRIP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102008:  view genomic region     (about GC identifiers)

Start:
102,004,319 bp from pter      End:
102,067,129 bp from pter
Size:
62,811 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,397,108-101,427,419     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PKRI1_HUMAN, Q9H875 (See protein sequence)
Recommended Name: PRKR-interacting protein 1  
Size: 184 amino acids; 20997 Da
Subunit: Interacts with EIF2AK2 (By similarity)
Subcellular location: Nucleus, nucleolus (By similarity)
Secondary accessions: Q8NDM6 Q96CF8

Explore the universe of human proteins at neXtProt for PRKRIP1: NX_Q9H875

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H875

  • PRKRIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078929.1  
    ENSEMBL proteins: 
     ENSP00000419270   ENSP00000420136   ENSP00000381010   ENSP00000346837  

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    Uscn Proteins for PRKRIP1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--


    PRKRIP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PRKRIP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009548 DUF1168

    Graphical View of Domain Structure for InterPro Entry Q9H875

    ProtoNet protein and cluster: Q9H875

    UniProtKB/Swiss-Prot: PKRI1_HUMAN, Q9H875
    Similarity: Belongs to the PRKRIP1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PKRI1_HUMAN, Q9H875
    Function: Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity)

    miRNA
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    hsa-miR-607 hsa-miR-516b* hsa-miR-548o hsa-miR-373* hsa-miR-1323 hsa-miR-516a-3p hsa-miR-24 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidPRKRIP1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IEA--
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--


    PRKRIP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PRKRIP1:
     Actin fiber cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRKRIP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PRKRIP1 (Q9H8752, 3 ENSP000003810104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-66518 I2D: score=4 STRING: ENSP00000347358
    EIF2AK2P195253, ENSP000002330574I2D: score=2 STRING: ENSP00000233057
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity ----
    GO:0042326negative regulation of phosphorylation ----


    PRKRIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRKRIP1
    Search CenterWatch for drugs/clinical trials and news about PRKRIP1 / PKRI1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKRIP1 gene: 
    NM_024653.3  

    Unigene Cluster for PRKRIP1:

    PRKR interacting protein 1 (IL11 inducible)
    Hs.722104  [show with all ESTs]
    Unigene Representative Sequence: AK124753
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477886 ENST00000469763(uc022ajf.1) ENST00000482549 ENST00000496391(uc003uze.2 uc003uzd.1 uc011kkq.1 uc003uzh.2 uc011kkr.1)
    ENST00000482465 ENST00000462601 ENST00000397912 ENST00000468316 ENST00000354783


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    hsa-miR-607 hsa-miR-516b* hsa-miR-548o hsa-miR-373* hsa-miR-1323 hsa-miR-516a-3p hsa-miR-24 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidPRKRIP1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF178686.1 AK023964.1 AK097289.1 AK124753.1 AK294664.1 AK298774.1 AL833837.1 BC014298.2 
    BC063572.1 NR_038967.1 

    15 DOTS entries:

    DT.310630  DT.100689840  DT.121040242  DT.92388280  DT.100787003  DT.100787001  DT.121040545  DT.100787002 
    DT.100024896  DT.100836638  DT.101978424  DT.121040337  DT.121040544  DT.95270987  DT.99966440 

    24/334 AceView cDNA sequences (see all 334):

    BI007726 BI006355 BQ327676 AI628098 BI006344 BF823561 AI674519 AI299332 
    CR598349 BM767860 BC066362 AI874317 AA419599 BQ056479 BP345583 BF823552 
    AA425835 BI006360 AW271744 BQ223930 BM767522 BI006359 AU159482 AI129946 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKRIP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                      -                                                                     
    SP2:                                                                                            -               
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                -           -               


    ECgene alternative splicing isoforms for PRKRIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKRIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    PRKRIP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKRIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKRIP1

    SOURCE GeneReport for Unigene cluster: Hs.722104
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKRIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKRIP1 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkrip11 , 5 Prkr interacting protein 1 (IL11 inducible)1, 5 90.22(n)1
    92.39(a)1
      5 (75.88 cM)5
    668011  NM_025774.31  NP_080050.11 
     1361781275 
    chicken
    (Gallus gallus)
    Aves PRKRIP11 PRKR interacting protein 1 (IL11 inducible) 73.63(n)
    78.57(a)
      417508  XM_001233516.2  XP_001233517.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237532 Xenopus laevis transcribed sequence with weak similarity more 73.56(n)    CF282792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurog32 neurogenin 3 76.3(n)    AL919094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84411 CG8441 52.47(n)
    48.39(a)
      36792  NM_137250.3  NP_611094.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F37A4.21 Protein F37A4.2 51.6(n)
    44.52(a)
      175947  NM_066073.4  NP_498474.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G152706
    uncharacterized protein
    26(a)
    1 ↔ 1
    2(6637878-6639419)
    rice
    (Oryza sativa)
    Liliopsida --
    expressed protein
    28(a)
    1 ↔ 1
    9(489930-492986)


    ENSEMBL Gene Tree for PRKRIP1 (if available)
    TreeFam Gene Tree for PRKRIP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/607 NCBI SNPs in PRKRIP1 are shown (see all 607    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115597311,2
    F,--96654483(+) GAAACG/TAAATC 2 -- int13Minor allele frequency- T:0.40CSA 5
    rs1133703781,2
    C,--96654509(+) CCAGCG/ACCGTG 2 -- int12Minor allele frequency- A:0.02NA 122
    rs102779961,2
    C,--96654869(+) GAAGAG/CGGGGA 2 -- int1 trp33Minor allele frequency- C:0.07NA WA 240
    rs731898061,2
    --96655066(+) CAGACA/GGCAGT 2 -- int10--------
    rs102782741,2
    C,--96655133(+) GGGTCG/AGGAAG 2 -- int13Minor allele frequency- A:0.07NA WA 240
    rs1146851491,2
    C,F,--96655246(+) CACCCG/ATGAGA 2 -- int11Minor allele frequency- A:0.03WA 118
    rs37475291,2
    C,F,H,--96655635(-) CCTTGC/TGGGGG 2 -- int1 ese38Minor allele frequency- T:0.02EA NS NA 2408
    rs1117604841,2
    C,--96655864(+) CGTTTA/GTTTAG 2 -- int12Minor allele frequency- G:0.03CSA WA 120
    rs760060151,2
    C,F,--96656131(+) CCTGGG/TTGTGT 2 -- int11Minor allele frequency- T:0.06WA 118
    rs760582611,2
    F,--96656138(+) GTGTGC/TACAAG 2 -- int11Minor allele frequency- T:0.04EA 120

    HapMap Linkage Disequilibrium report for PRKRIP1 (102004319 - 102067129 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PRKRIP1
         2 CNVs: 4553 3693

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKRIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKRIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PRKRIP1 for disorders           About GeneDecksing

    1 disease for PRKRIP1:    About MalaCards
    malaria


    Export disorders for PRKRIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKRIP1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with PRKRIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R. (PubMed id 12679338)1, 3 Yin Z....Yang Y.C. (2003)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1 Will C.L.... Luehrmann R. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79706 HGNC: 21894 AceView: PRKRIP1 Ensembl:ENSG00000128563 euGenes: HUgn79706
    ECgene: PRKRIP1 H-InvDB: PRKRIP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKRIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKRIP1 gene:
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