Aliases for PRKG2 Gene
External Ids for PRKG2 Gene
Previous GeneCards Identifiers for PRKG2 Gene
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PRKG2 Gene
PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include Chromosome 4Q21 Deletion Syndrome and Gout. Among its related pathways are NO-dependent CFTR activation (normal and CF) and Platelet activation, signaling and aggregation. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is PRKG1.
Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1alpha and PKG1beta.