Aliases for PRKG2 Gene
External Ids for PRKG2 Gene
Previous GeneCards Identifiers for PRKG2 Gene
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PRKG2 Gene
PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include hyperphenylalaninemia. Among its related pathways are Signaling by GPCR and Platelet homeostasis. GO annotations related to this gene include protein kinase activity and cGMP-dependent protein kinase activity. An important paralog of this gene is PRKACA.
Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon splicing two isoforms of PKG1, PKG1alpha and PKG1beta, exist. PKG1 and PKG2 are expressed in different cell types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function, spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and histidine triad protein 1 (HINT1).