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Aliases for PRKG2 Gene

Aliases for PRKG2 Gene

  • Protein Kinase, CGMP-Dependent, Type II 2 3 5
  • CGMP-Dependent Protein Kinase II 3 4
  • EC 4 63
  • PRKGR2 3 4
  • CGKII 3 4
  • CGK2 3 4
  • Testicular Tissue Protein Li 99 3
  • EC 2.7.11 63
  • CGK 2 4

External Ids for PRKG2 Gene

Previous GeneCards Identifiers for PRKG2 Gene

  • GC04M081905
  • GC04M082304
  • GC04M082468
  • GC04M082367
  • GC04M082009
  • GC04M077753

Summaries for PRKG2 Gene

Entrez Gene Summary for PRKG2 Gene

  • This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PRKG2 Gene

PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include chromosome 4q21 deletion syndrome and hyperphenylalaninemia. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is PRKACA.

Tocris Summary for PRKG2 Gene

  • Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1alpha and PKG1beta.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKG2 Gene

Genomics for PRKG2 Gene

Regulatory Elements for PRKG2 Gene

Promoters for PRKG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKG2 Gene

81,087,370 bp from pter
81,216,743 bp from pter
129,374 bases
Minus strand

Genomic View for PRKG2 Gene

Genes around PRKG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKG2 Gene

Proteins for PRKG2 Gene

  • Protein details for PRKG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cGMP-dependent protein kinase 2
    Protein Accession:
    Secondary Accessions:
    • B4DMX3
    • E7EPE6
    • O00125
    • O60916

    Protein attributes for PRKG2 Gene

    762 amino acids
    Molecular mass:
    87432 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRKG2 Gene

    Alternative splice isoforms for PRKG2 Gene


neXtProt entry for PRKG2 Gene

Proteomics data for PRKG2 Gene at MOPED

Post-translational modifications for PRKG2 Gene

Antibody Products

Domains & Families for PRKG2 Gene

Gene Families for PRKG2 Gene

Suggested Antigen Peptide Sequences for PRKG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 2 cyclic nucleotide-binding domains.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
genes like me logo Genes that share domains with PRKG2: view

Function for PRKG2 Gene

Molecular function for PRKG2 Gene

GENATLAS Biochemistry:
protein kinase,cGMD dependent,type II,87kDa,putatively involved in regulation of intestinal fluid secretion
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding of cGMP results in enzyme activation.

Enzyme Numbers (IUBMB) for PRKG2 Gene

Gene Ontology (GO) - Molecular Function for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8607838
GO:0004692 cGMP-dependent protein kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with PRKG2: view
genes like me logo Genes that share phenotypes with PRKG2: view

Animal Models for PRKG2 Gene

MGI Knock Outs for PRKG2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKG2 Gene

Localization for PRKG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKG2 Gene

Apical cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for PRKG2 Gene COMPARTMENTS Subcellular localization image for PRKG2 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with PRKG2: view

Pathways & Interactions for PRKG2 Gene

genes like me logo Genes that share pathways with PRKG2: view

SIGNOR curated interactions for PRKG2 Gene


Gene Ontology (GO) - Biological Process for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 8607838
GO:0046209 nitric oxide metabolic process TAS --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with PRKG2: view

Drugs & Compounds for PRKG2 Gene

(5) Drugs for PRKG2 Gene - From: Novoseek, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
KT 5823 Pharma Positive, Allosteric regulator Selective protein kinase G inhibitor 0

(7) Additional Compounds for PRKG2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
cGMP Dependent Kinase Inhibitor Peptide
Rp-8-pCPT-cGMPS sodium

(4) Tocris Compounds for PRKG2 Gene

Compound Action Cas Number
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
KT 5823 Selective protein kinase G inhibitor 126643-37-6
Rp-8-Br-PET-cGMPS Protein kinase G inhibitor 185246-32-6
Rp-8-pCPT-cGMPS sodium PKG inhibitor 208445-07-2
genes like me logo Genes that share compounds with PRKG2: view

Transcripts for PRKG2 Gene

mRNA/cDNA for PRKG2 Gene

Unigene Clusters for PRKG2 Gene

Protein kinase, cGMP-dependent, type II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKG2 Gene

No ASD Table

Relevant External Links for PRKG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKG2 Gene

mRNA expression in normal human tissues for PRKG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKG2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.5).

Protein differential expression in normal tissues from HIPED for PRKG2 Gene

This gene is overexpressed in Spleen (31.0), Monocytes (23.9), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRKG2 Gene

SOURCE GeneReport for Unigene cluster for PRKG2 Gene Hs.570833

mRNA Expression by UniProt/SwissProt for PRKG2 Gene

Tissue specificity: Highly concentrated in brain, lung and intestinal mucosa.
genes like me logo Genes that share expression patterns with PRKG2: view

Protein tissue co-expression partners for PRKG2 Gene

Primer Products

In Situ Assay Products

Orthologs for PRKG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRKG2 35
  • 92.96 (n)
  • 97.24 (a)
PRKG2 36
  • 98 (a)
(Canis familiaris)
Mammalia PRKG2 35
  • 92.26 (n)
  • 96.72 (a)
PRKG2 36
  • 97 (a)
(Mus musculus)
Mammalia Prkg2 35
  • 88.76 (n)
  • 96.85 (a)
Prkg2 16
Prkg2 36
  • 97 (a)
(Pan troglodytes)
Mammalia PRKG2 35
  • 99.78 (n)
  • 100 (a)
PRKG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Prkg2 35
  • 88.63 (n)
  • 96.33 (a)
(Monodelphis domestica)
Mammalia PRKG2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia PRKG2 36
  • 84 (a)
(Gallus gallus)
Aves PRKG2 35
  • 76.38 (n)
  • 80.93 (a)
PRKG2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia PRKG2 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prkg2 35
  • 71.75 (n)
  • 72.24 (a)
(Danio rerio)
Actinopterygii prkg2 35
  • 68.38 (n)
  • 70.09 (a)
prkg2 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4839 37
  • 41 (a)
for 37
  • 52 (a)
Pkg21D 37
  • 49 (a)
Pkg21D 35
  • 54.56 (n)
  • 51.77 (a)
CG4839 36
  • 28 (a)
Pkg21D 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008585 35
  • 26.5 (n)
  • 6.74 (a)
(Caenorhabditis elegans)
Secernentea egl-4 37
  • 44 (a)
pkg-1 35
  • 55.29 (n)
  • 49.44 (a)
pkg-2 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK1 36
  • 36 (a)
TPK2 36
  • 35 (a)
TPK3 36
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.44 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for PRKG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKG2 Gene

Gene Tree for PRKG2 (if available)
Gene Tree for PRKG2 (if available)

Paralogs for PRKG2 Gene

Paralogs for PRKG2 Gene

genes like me logo Genes that share paralogs with PRKG2: view

Variants for PRKG2 Gene

Sequence variations from dbSNP and Humsavar for PRKG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34616910 - 81,204,731(+) TCCGG(C/T)GGACC reference, missense
VAR_040609 A colorectal adenocarcinoma sample
rs34956759 - 81,204,983(+) CAGTG(C/G)TGAGG reference, missense
rs4149 -- 81,197,198(-) ATAGC(A/G)TCATT intron-variant
rs788855 -- 81,207,476(-) ATGCC(C/T)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKG2 Gene

Variant ID Type Subtype PubMed ID
nsv829984 CNV Gain 17160897
esv2657932 CNV Deletion 23128226
esv22713 CNV Loss 19812545
esv2526820 CNV Deletion 19546169

Variation tolerance for PRKG2 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKG2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKG2 Gene

Disorders for PRKG2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
  • hpa
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search PRKG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRKG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKG2 Gene

Publications for PRKG2 Gene

  1. Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. (PMID: 7498513) Fujii M. … Ayusawa D. (FEBS Lett. 1995) 2 3 4 23 67
  2. The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. (PMID: 18678579) Chang S.J. … Lai H.M. (Ann. Rheum. Dis. 2009) 3 23
  3. Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. (PMID: 19543319) Swartling F.J. … Westermark B. (Oncogene 2009) 3 23
  4. The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry. (PMID: 15555551) Zhan X. … Desiderio D.M. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. Autophosphorylation of cGMP-dependent protein kinase type II. (PMID: 12764134) Vaandrager A.B. … de Jonge H.R. (J. Biol. Chem. 2003) 3 23

Products for PRKG2 Gene

Sources for PRKG2 Gene

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