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Aliases for PRKG2 Gene

Aliases for PRKG2 Gene

  • Protein Kinase, CGMP-Dependent, Type II 2 3 5
  • CGMP-Dependent Protein Kinase II 3 4
  • EC 2.7.11.12 4 61
  • PRKGR2 3 4
  • CGKII 3 4
  • CGK2 3 4
  • CGMP-Dependent Protein Kinase 2 3
  • Testicular Tissue Protein Li 99 3
  • EC 2.7.11 61
  • CGK 2 4

External Ids for PRKG2 Gene

Previous GeneCards Identifiers for PRKG2 Gene

  • GC04M081905
  • GC04M082304
  • GC04M082468
  • GC04M082367
  • GC04M082009
  • GC04M077753

Summaries for PRKG2 Gene

Entrez Gene Summary for PRKG2 Gene

  • This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PRKG2 Gene

PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include Chromosome 4Q21 Deletion Syndrome and Gout. Among its related pathways are Signaling in Gap Junctions and Regulation of lipolysis in adipocytes. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is PRKG1.

UniProtKB/Swiss-Prot for PRKG2 Gene

  • Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).

Tocris Summary for PRKG2 Gene

  • Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1alpha and PKG1beta.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKG2 Gene

Genomics for PRKG2 Gene

Regulatory Elements for PRKG2 Gene

Enhancers for PRKG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G081210 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +0.8 768 10.8 ZSCAN4 ZNF366 EGR2 CEBPB USF2 ZNF398 REST MAFF RAD51 KLF16 PRKG2 LOC101928942
GH04G081191 0.7 dbSUPER 16.4 +23.6 23591 2.5 ZFP64 ZBTB11 ZNF140 ZNF426 ZNF394 ZBTB8A REST ZNF623 ATF2 ZNF781 PRKG2 LOC101928942 FGF5
GH04G081346 0.7 ENCODE 16.1 -131.4 -131352 2.5 ZNF263 CTCF ZNF654 ZBTB11 HLF TRIM22 BMI1 REST RAD21 GABPA PRKG2 RNU5A-2P GC04M081429
GH04G081378 0.6 ENCODE 16.6 -163.3 -163337 3.6 PRDM6 SCRT2 FEZF1 FOXP2 ZBTB40 WT1 ZNF507 PRKG2 RASGEF1B GC04M081429 RNU5A-2P
GH04G081351 0.6 ENCODE 16.3 -135.1 -135079 0.2 CTCF ZNF654 TRIM22 REST RAD21 KLF16 SMARCA4 SMC3 ZNF143 PRKG2 RNU5A-2P GC04M081429
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKG2 Gene

Chromosome:
4
Start:
81,087,370 bp from pter
End:
81,216,743 bp from pter
Size:
129,374 bases
Orientation:
Minus strand

Genomic View for PRKG2 Gene

Genes around PRKG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKG2 Gene

Proteins for PRKG2 Gene

  • Protein details for PRKG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13237-KGP2_HUMAN
    Recommended name:
    cGMP-dependent protein kinase 2
    Protein Accession:
    Q13237
    Secondary Accessions:
    • B4DMX3
    • E7EPE6
    • O00125
    • O60916

    Protein attributes for PRKG2 Gene

    Size:
    762 amino acids
    Molecular mass:
    87432 Da
    Quaternary structure:
    • Interacts with GRIA1/GLUR1.

    Three dimensional structures from OCA and Proteopedia for PRKG2 Gene

    Alternative splice isoforms for PRKG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKG2 Gene

Selected DME Specific Peptides for PRKG2 Gene

Q13237:
  • GIIYRDLK
  • CLVIDRETFNQ
  • TYNLILKGI
  • GFNWEGL
  • TLGVGGFGRVELV
  • ERELRRK
  • KTWTFCGTPEYVAPE
  • LGIIYRD
  • RDLKPEN
  • LYRTFKD
  • KYVYMLLEAC
  • GELAILYNC
  • ILNKGHD

Post-translational modifications for PRKG2 Gene

Antibody Products

  • Abcam antibodies for PRKG2

Domains & Families for PRKG2 Gene

Gene Families for PRKG2 Gene

Suggested Antigen Peptide Sequences for PRKG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13237

UniProtKB/Swiss-Prot:

KGP2_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
genes like me logo Genes that share domains with PRKG2: view

Function for PRKG2 Gene

Molecular function for PRKG2 Gene

GENATLAS Biochemistry:
protein kinase,cGMD dependent,type II,87kDa,putatively involved in regulation of intestinal fluid secretion
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding of cGMP results in enzyme activation.
UniProtKB/Swiss-Prot Function:
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).

Enzyme Numbers (IUBMB) for PRKG2 Gene

Gene Ontology (GO) - Molecular Function for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8607838
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004692 cGMP-dependent protein kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with PRKG2: view
genes like me logo Genes that share phenotypes with PRKG2: view

Animal Models for PRKG2 Gene

MGI Knock Outs for PRKG2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKG2 Gene

Localization for PRKG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKG2 Gene

Apical cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKG2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with PRKG2: view

Pathways & Interactions for PRKG2 Gene

genes like me logo Genes that share pathways with PRKG2: view

SIGNOR curated interactions for PRKG2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRKG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS,IMP 15905169
GO:0007165 signal transduction TAS 8607838
GO:0016310 phosphorylation IEA --
GO:0036289 peptidyl-serine autophosphorylation IEA --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with PRKG2: view

Drugs & Compounds for PRKG2 Gene

(8) Drugs for PRKG2 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
cGMP Dependent Kinase Inhibitor Peptide Pharma Inhibitor of protein kinases G and A 0
KT 5823 Pharma Positive, Allosteric regulator Selective protein kinase G inhibitor 0
Rp-8-Br-PET-cGMPS Pharma Protein kinase G inhibitor 0
GF 109203X Pharma Protein kinase C,MLCK,PKG and PKA inhibitor, Protein kinase C inhibitor 0

(5) Additional Compounds for PRKG2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Rp-8-pCPT-cGMPS sodium
208445-07-2

(4) Tocris Compounds for PRKG2 Gene

Compound Action Cas Number
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
KT 5823 Selective protein kinase G inhibitor 126643-37-6
Rp-8-Br-PET-cGMPS Protein kinase G inhibitor 185246-32-6
Rp-8-pCPT-cGMPS sodium PKG inhibitor 208445-07-2

(4) ApexBio Compounds for PRKG2 Gene

Compound Action Cas Number
cGMP Dependent Kinase Inhibitor Peptide 82801-73-8
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
KT 5823 126643-37-6
Rp-8-Br-PET-cGMPS 185246-32-6
genes like me logo Genes that share compounds with PRKG2: view

Drug Products

Transcripts for PRKG2 Gene

mRNA/cDNA for PRKG2 Gene

Unigene Clusters for PRKG2 Gene

Protein kinase, cGMP-dependent, type II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKG2 Gene

No ASD Table

Relevant External Links for PRKG2 Gene

GeneLoc Exon Structure for
PRKG2
ECgene alternative splicing isoforms for
PRKG2

Expression for PRKG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKG2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.5).

Protein differential expression in normal tissues from HIPED for PRKG2 Gene

This gene is overexpressed in Spleen (31.0), Monocytes (23.9), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRKG2 Gene



Protein tissue co-expression partners for PRKG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKG2 Gene:

PRKG2

SOURCE GeneReport for Unigene cluster for PRKG2 Gene:

Hs.570833

mRNA Expression by UniProt/SwissProt for PRKG2 Gene:

Q13237-KGP2_HUMAN
Tissue specificity: Highly concentrated in brain, lung and intestinal mucosa.

Evidence on tissue expression from TISSUES for PRKG2 Gene

  • Liver(4.2)
  • Heart(4.1)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with PRKG2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKG2 Gene

Orthologs for PRKG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKG2 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia PRKG2 34 35
  • 92.96 (n)
dog
(Canis familiaris)
Mammalia PRKG2 34 35
  • 92.26 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKG2 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkg2 34 16 35
  • 88.76 (n)
rat
(Rattus norvegicus)
Mammalia Prkg2 34
  • 88.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKG2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKG2 34 35
  • 76.38 (n)
lizard
(Anolis carolinensis)
Reptilia PRKG2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkg2 34
  • 71.75 (n)
zebrafish
(Danio rerio)
Actinopterygii prkg2 34 35
  • 68.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pkg21D 36 34 35
  • 54.56 (n)
for 36
  • 52 (a)
CG4839 36 35
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008585 34
  • 26.5 (n)
worm
(Caenorhabditis elegans)
Secernentea pkg-1 34
  • 55.29 (n)
egl-4 36
  • 44 (a)
pkg-2 35
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK1 35
  • 36 (a)
ManyToMany
TPK2 35
  • 35 (a)
ManyToMany
TPK3 35
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.44 34
Species where no ortholog for PRKG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKG2 Gene

ENSEMBL:
Gene Tree for PRKG2 (if available)
TreeFam:
Gene Tree for PRKG2 (if available)

Paralogs for PRKG2 Gene

Variants for PRKG2 Gene

Sequence variations from dbSNP and Humsavar for PRKG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_040609 A colorectal adenocarcinoma sample
rs1000004830 -- 81,212,388(+) CAGAT(-/AAAC)AAGCA intron-variant
rs10000303 -- 81,169,535(+) TTCCT(C/T)TGGTT intron-variant
rs1000031248 -- 81,191,143(+) GTTTA(C/T)TGCAG intron-variant
rs1000057426 -- 81,102,602(+) CAAGC(A/G)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKG2 Gene

Variant ID Type Subtype PubMed ID
esv22713 CNV loss 19812545
esv2526820 CNV deletion 19546169
esv2657932 CNV deletion 23128226
esv3601143 CNV gain 21293372
esv3601148 CNV loss 21293372
nsv829984 CNV gain 17160897

Variation tolerance for PRKG2 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKG2 Gene

Human Gene Mutation Database (HGMD)
PRKG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKG2 Gene

Disorders for PRKG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRKG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 4q21 deletion syndrome
  • 4q21 microdeletion syndrome
gout
  • articular gout
hyperphenylalaninemia
  • hyperphenylalaninemia, non-phenylketonuric
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search PRKG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKG2

Genetic Association Database (GAD)
PRKG2
Human Genome Epidemiology (HuGE) Navigator
PRKG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKG2
genes like me logo Genes that share disorders with PRKG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKG2 Gene

Publications for PRKG2 Gene

  1. Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. (PMID: 7498513) Fujii M. … Ayusawa D. (FEBS Lett. 1995) 2 3 4 22 64
  2. The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. (PMID: 18678579) Chang S.J. … Lai H.M. (Ann. Rheum. Dis. 2009) 3 22 46 64
  3. Characterization of the gene encoding the human type II cGMP- dependent protein kinase. (PMID: 9535793) Witczak O. … Sandberg M. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64
  4. Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. (PMID: 8607838) Orstavik S. … Sandberg M. (Biochem. Biophys. Res. Commun. 1996) 3 4 22 64
  5. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. (PMID: 26769964) Campbell J.C. … Kim C. (J. Biol. Chem. 2016) 3 4 64

Products for PRKG2 Gene

  • Addgene plasmids for PRKG2

Sources for PRKG2 Gene

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