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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRKG2 Gene

protein-coding GIFtS: 67
GCID: GC04M082009

protein kinase, cGMP-dependent, type II

Explore 12 diseases affiliated with
PRKG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase, CGMP-Dependent, Type II¹ ²		CGMP-Dependent Protein Kinase II² ³
PRKGR2¹ ² ³ ⁵		EC 2.7.11.12³ ⁸
CGKII¹		CGMP-Dependent Protein Kinase 2²
CGK2¹		EC 2.7.11⁸
CGK 2² ³

External Ids:	HGNC: 9416¹	Entrez Gene: 5593²	Ensembl: ENSG00000138669⁷	OMIM: 601591⁵	UniProtKB: Q13237³

Export aliases for PRKG2 gene to outside databases

Previous GC identifers: GC04M081905 GC04M082304 GC04M082468 GC04M082367 GC04M077753

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

summary for PRKG2:

AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of

alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of

cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to

stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis.

The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by

phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by

calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates

allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in

metabolically active tissues such as the skeletal muscles and liver.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRKG2 gene promoter:
Bach1 RFX1 MEF-2 Pax-6 C/EBPalpha Evi-1 PPAR-alpha FOXJ2 (long isoform) aMEF-2 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKG2 promoter sequence

Search SABiosciences Chromatin IP Primers for PRKG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1-q21.1 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q13.1-q21.1

PRKG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKG2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M082009: view genomic region (about GC identifiers)

Start:	82,009,837 bp from pter	End:	82,136,218 bp from pter
Size:	126,382 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237 (See protein sequence)

Recommended Name: cGMP-dependent protein kinase 2

Size: 762 amino acids; 87432 Da

Subcellular location: Apical cell membrane; Lipid-anchor

Secondary accessions: O00125 O60916

Explore the universe of human proteins at neXtProt for PRKG2: NX_Q13237

Post-translational modifications:

Myristoylation mediates membrane localization¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13237

4/13 DME Specific Peptides for PRKG2 (Q13237) (see all 13)

GFNWEGL

LYRTFKD

ERELRRK

ILNKGHD

PRKG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006250.1

ENSEMBL proteins:

ENSP00000378945 ENSP00000264399 ENSP00000389038 ENSP00000439967

Reactome Protein details: Q13237
Human Recombinant Protein Products for PRKG2:

	EMD Millipore Purified and/or Recombinant PRKG2 Protein
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	Novus Biologicals PRKG2 Proteins Novus Biologicals PRKG2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRKG2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0016324	apical plasma membrane	IEA	--

PRKG2 for ontologies About GeneDecksing

PRKG2 Antibody Products:

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	Uscn ELISAs and CLIAs for PRKG2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRKG2 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR018488 cNMP-bd_CS

Graphical View of Domain Structure for InterPro Entry Q13237

ProtoNet protein and cluster: Q13237

3 Blocks protein families:

IPB000595 Cyclic nucleotide-binding domain

IPB000961 Protein kinase C-terminal domain

IPB002374 cGMP-dependent protein kinase signature

UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 2 cyclic nucleotide-binding domains

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KGP2_HUMAN, Q13237

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Binding of cGMP results in enzyme activation

Genatlas biochemistry entry for PRKG2:

protein kinase,cGMD dependent,type II,87kDa,putatively involved in regulation of intestinal fluid secretion

Enzyme Numbers (IUBMB): EC 2.7.11.12¹ ² EC 2.7.11²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	8607838
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004692	cGMP-dependent protein kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0030553	cGMP binding	IEA	--

PRKG2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PRKG2:

Decreased 12E8 and total tau p

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prkg2):

adipose tissue	craniofacial	digestive/alimentary	growth/size	homeostasis/metabolism
limbs/digits/tail	skeleton

PRKG2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Prkg2^tm1Pfe for PRKG2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRKG2

miRNA Products:		OriGene 3'-UTR Clone: PRKG2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKG2
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKG2:
		hsa-miR-877* hsa-miR-544 hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-548c-3p hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: PRKG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKG2 (see all 7) OriGene shRNA RFP: PRKG2 OriGene siRNA: PRKG2
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		GenScript: all cDNA clones in your preferred vector: PRKG2 (NM_006259)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKG2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKG2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Nitric oxide stimulates guanylate cyclase

	Nitric oxide stimulates guanylate cyclase	1.00			Platelet homeostasis	0.34
	cGMP effects	0.75

Metabolism of nitric oxide

	eNOS activation and regulation	1.00			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.59
	Metabolism of nitric oxide	1.00

Signaling in Gap Junctions

Signaling in Gap Junctions

1.00

Gap junction

0.31

Development Angiotensin activation of ERK

Development EDNRB signaling

0.54

Development_EDNRB signaling

0.54

Sweet Taste Signaling

Cellular Effects of Sildenafil

0.46

Sperm Motility

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PRKG2

Development EDNRB signaling

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKG2

	Cellular Effects of Sildenafil
	Sertoli-Sertoli Cell Junction Dynamics
	Sperm Motility
	Signaling in Gap Junctions
	Dopamine-DARPP32 Feedback onto cAMP Pathway

3 GeneGo (Thomson Reuters) Pathways for PRKG2

	Development EDNRB signaling
	Regulation of CFTR activity (norm and CF)
	NO-dependent CFTR activation (normal and CF)

5/8 Reactome Pathways for PRKG2 (see all 8)

	Hemostasis
	cGMP effects
	eNOS activation and regulation
	Metabolism of nitric oxide
	Metabolism

4 Kegg Pathways (Kegg details for PRKG2):

	Gap junction
	Long-term depression
	Olfactory transduction
	Salivary secretion

PRKG2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRKG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/19 Interacting proteins for PRKG2 (Q13237³ ENSP00000264399⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYLK	Q15746³, ENSP00000353452⁴	I2D: score=2 STRING: ENSP00000353452
PLCB3	Q01970³, ENSP00000279230⁴	I2D: score=1 STRING: ENSP00000279230
PTS	Q03393³, ENSP00000280362⁴	I2D: score=1 STRING: ENSP00000280362
LASP1	Q14847³, ENSP00000325240⁴	I2D: score=1 STRING: ENSP00000325240
YWHAB	P31946³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	TAS	8607838
GO:0007165	signal transduction	TAS	8607838
GO:0007596	blood coagulation	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046209	nitric oxide metabolic process	TAS	--

PRKG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRKG2 for compounds About GeneDecksing

EMD Millipore small molecules for PRKG2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PRKG2

Compounds for PRKG2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Dorsomorphin dihydrochloride	Potent and selective AMPK inhibitor	[1219168-18-9]
Metformin hydrochloride	Activator of LKB1/AMPK; antidiabetic agent	[1115-70-4]
SAMS Peptide	AMP-activated protein kinase substrate	[125911-68-4]
AICAR	AMPK activator	[2627-69-2]
PT 1	AMPK activator	[331002-70-1]

2 HMDB Compounds for PRKG2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

6 Novoseek chemical compound relationships for PRKG2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cgmp	74.7	52	18728399 (3), 18031684 (3), 15722341 (3), 19543319 (3) (see all 18)
enterotoxin	63.1	1	10864932 (1)
guanylate	52.3	4	12011439 (1), 14988827 (1), 17684063 (1), 11444148 (1)
nitric oxide	38	5	18728399 (2), 10593861 (1), 17684063 (1), 18514181 (1)
bicarbonate	15.1	1	11444148 (1)
calcium	12.9	1	10769198 (1)

Search CenterWatch for drugs/clinical trials and news about PRKG2 / KGP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRKG2 gene:

NM_006259.1

Unigene Cluster for PRKG2:

Protein kinase, cGMP-dependent, type II

Hs.570833 [show with all ESTs]

Unigene Representative Sequence: NM_006259

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395578(uc011cch.1) ENST00000509169 ENST00000509474 ENST00000456882

ENST00000264399(uc011ccf.1 uc011ccg.1 uc003hmh.2) ENST00000418486

ENST00000545647

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKG2:
		hsa-miR-877* hsa-miR-544 hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-548c-3p hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: PRKG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKG2 (see all 7) OriGene shRNA RFP: PRKG2 OriGene siRNA: PRKG2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKG2

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		GenScript: all cDNA clones in your preferred vector: PRKG2 (NM_006259)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKG2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKG2

Additional cDNA sequence:

AK296979.1 AK297673.1 AK316140.1 D70899.1 X94612.1

2 DOTS entries:

DT.407659 DT.121276345

11 AceView cDNA sequences:

NM_006259 BQ232970 X94612 BX101259 BX641735 AI005557 D70899 AI827981

BX508960 AA913837 AI383235

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRKG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCCAGGGA

About this image

PRKG2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Ovary

Lumbar Vertebral Body

Somite

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRKG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKG2

SOURCE GeneReport for Unigene cluster: Hs.570833

UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237

Tissue specificity: Highly concentrated in brain, lung and intestinal mucosa

SABiosciences Expression via Pathway-Focused PCR Arrays including PRKG2:

Hypertension in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Gap Junctions in human mouse rat

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRKG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKG2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRKG2 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRKG2¹	protein kinase, cGMP-dependent, type II	76.7(n) 81.17(a)		428753 XM_003641188.1 XP_003641236.1
lizard (Anolis carolinensis)	Reptilia	PRKG2⁶	--	81(a)	1 ↔ 1	5(42422645-42476899)
African clawed frog (Xenopus laevis)	Amphibia	BX845593.1²	--	73.98(n)		BX845593.1
zebrafish (Danio rerio)	Actinopterygii	prkg2¹	protein kinase, cGMP-dependent, type II	68.38(n) 70.09(a)		100125912 NM_001105279.1 NP_001098749.1
fruit fly (Drosophila melanogaster)	Insecta	for³ Pkg21D¹	protein amino acid phosphorylation protein serine/threonine more³ cGMP-dependent protein kinase 21D¹	52(a) (best of 3)³ 53.4(n)¹ 49.1(a)¹		33253¹ NM_057865.3¹ NP_477213.1¹
worm (Caenorhabditis elegans)	Secernentea	egl-4³	cyclic-GMP-dependent protein kinase	44(a)		IV(1848075-1879944) --

ENSEMBL Gene Tree for PRKG2 (if available)
TreeFam Gene Tree for PRKG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRKG2 gene

PRKX² PRKACG² PRKACA² PRKG1² PRKACB²

18/60 SIMAP similar genes for PRKG2 using alignment to 3 protein entries: KGP2_HUMAN (see all proteins) (see all similar genes):

MARK4 PRKG1 KIN27 PRKACB PRKACA PRKY

RPS6KA2 PRKX PRKACG STK32A PHKG1 PRKCZ

RPS6KB2 SGK2 MAPK8 PDPK2 PkB-like 1 RPS6KA3

PRKG2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144706509^1,2		--	82009524(+)	`AATCCC/TGGAAC`	1	--	ds500¹		0	--	--	--	--
rs3796804^1,2	C,F,A,H	--	82009707(+)	`GGAGAG/TTGCAA`	1	--	ds500¹		29		EA NA NS WA CSA	4391
rs146687720^1,2		--	82009734(+)	`ATGCTA/GTTGTC`	1	--	ds500¹		0	--	--	--	--
rs115866885^1,2	C	--	82009785(+)	`CCTGTC/TTTAAC`	1	--	ds500¹		1		WA	118
rs181981154^1,2		--	82009837(+)	`AAAAGC/TGCTAT`	1	--	ut3¹		0	--	--	--	--
rs140258650^1,2		--	82009904(+)	`TTAACA/GATGAT`	1	--	ut3¹		0	--	--	--	--
rs114800896^1,2	C	--	82009941(+)	`CAACTA/CTCACA`	1	--	ut3¹		0	--	--	--	--
rs17005051^1,2	C,F,H	--	82010007(+)	`TATATT/CTTCCT`	1	--	ut3¹ trp³		12		NA NS EA WA	1340
rs187199305^1,2		--	82010017(+)	`TTTCTA/GTTTAC`	1	--	ut3¹		0	--	--	--	--
rs76399471^1,2		--	82010076(+)	`GGTTGC/TGAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRKG2 (82009837 - 82136218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PRKG2
1 CNV: 98772
1 Indel: 63876
Human Gene Mutation Database (HGMD): PRKG2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRKG2 for disorders           About GeneDecksing

OMIM gene information: 601591    OMIM disorders: --

12 diseases for PRKG2:    About MalaCards

secretory diarrhea cystic fibrosis hyperphenylalaninemia alcohol dependence

myeloproliferative disorder diarrhea fibrosis gout

alcoholism lung cancer malaria neuronitis

1 Novoseek disease relationship for PRKG2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	55.7	5	9755058 (1), 12011439 (1), 10864932 (1), 9020133 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: PRKG2 (4 documents)

Export disorders for PRKG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRKG2 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with PRKG2)

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world of online information

Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. (PubMed id 7498513)^{1, 2, 3, 9} Fujii M....Ayusawa D. (1995)
Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. (PubMed id 8607838)^{1, 2, 9} Orstavik S.... Sandberg M. (1996)
Characterization of the gene encoding the human type II cGMP- dependent protein kinase. (PubMed id 9535793)^{1, 2, 9} Witczak O....Sandberg M. (1998)
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lin es. (PubMed id 19543319)^{1, 9} Swartling F.J....Westermark B. (2009)
Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II. (PubMed id 10531334)^{1, 9} Scherer-Oppliger T.... Thoeny B. (1999)
Autophosphorylation of cGMP-dependent protein kinase type II. (PubMed id 12764134)^{1, 9} Vaandrager A.B....de Jonge H.R. (2003)
Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. (PubMed id 7543493)^{1, 9} Markert T....Lohmann S.M. (1995)
N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II. (PubMed id 8636133)^{2, 9} Vaandrager A.B....de Jonge H.R. (1996)
The cyclic GMP-dependent protein kinase II gene associates with gout disease identified by genome-wide analysis and case-control study. (PubMed id 18678579)^{1, 9} Chang S.J....Lai H.M. (2008)
The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry. (PubMed id 15555551)^{1, 9} Zhan X. and Desiderio D.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5593	HGNC: 9416	AceView: PRKG2	Ensembl:ENSG00000138669	euGenes: HUgn5593
ECgene: PRKG2	Kegg: 5593	H-InvDB: PRKG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRKG2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRKG2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRKG2 gene
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Patent Information for PRKG2 gene:
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protein kinase, cGMP-dependent, type II

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protein kinase, cGMP-dependent, type II

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