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PRKG2 Gene

protein-coding   GIFtS: 68
GCID: GC04M082009

Protein Kinase, CGMP-Dependent, Type II

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CGMP-Dependent, Type II1 2     EC 2.7.11.123 8
PRKGR22 3 5     CGMP-Dependent Protein Kinase 22
cGK22 3     CGK 23
cGKII2 3     EC 2.7.118
CGMP-Dependent Protein Kinase II2 3     

External Ids:    HGNC: 94161   Entrez Gene: 55932   Ensembl: ENSG000001386697   OMIM: 6015915   UniProtKB: Q132373   

Export aliases for PRKG2 gene to outside databases

Previous GC identifers: GC04M081905 GC04M082304 GC04M082468 GC04M082367 GC04M077753


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKG2 Gene:
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded
protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought
to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple
transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for PRKG2 Gene:
PRKG2 (protein kinase, cGMP-dependent, type II) is a protein-coding gene. Diseases associated with PRKG2 include secretory diarrhea, and hyperphenylalaninemia. GO annotations related to this gene include protein kinase activity and cGMP-dependent protein kinase activity. An important paralog of this gene is PRKX.

summary for PRKG2 Gene:
Protein kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a
variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2. Due to alternative exon
splicing two isoforms of PKG1, PKG1alpha and PKG1beta, exist. PKG1 and PKG2 are expressed in different cell
types, with PKG1 at its highest concentrations in smooth muscle cells and platelets, whilst PKG2 is most
abundant in the brain, lungs and intestinal mucosa. PKGs exist as antiparallel homodimers and have roles in
smooth muscle relaxation (via phosphorylation of myosin light chain phosphatase), platelet function,
spermatozoa metabolism and hemodynamic homeostasis. In addition, it has been suggested that PKG has
anticancer properties due to its role in upregulating expression of the tumor suppressor genes p21, p27 and
histidine triad protein 1 (HINT1).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKG2 gene promoter:
         Bach1   RFX1   MEF-2   Pax-6   C/EBPalpha   Evi-1   PPAR-alpha   FOXJ2 (long isoform)   aMEF-2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKG2 promoter sequence
   Search Chromatin IP Primers for PRKG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1-q21.1   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q13.1-q21.1

PRKG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M082009:  view genomic region     (about GC identifiers)

Start:
82,009,837 bp from pter      End:
82,136,218 bp from pter
Size:
126,382 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237 (See protein sequence)
Recommended Name: cGMP-dependent protein kinase 2  
Size: 762 amino acids; 87432 Da
Secondary accessions: O00125 O60916

Explore the universe of human proteins at neXtProt for PRKG2: NX_Q13237

Explore proteomics data for PRKG2 at MOPED

Post-translational modifications: 

  • Myristoylation mediates membrane localization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKG2 (Q13237) (see all 13)
     GFNWEGL  LYRTFKD  ERELRRK  ILNKGHD 


    See PRKG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001269409.1  NP_001269410.1  NP_001269411.1  NP_001269412.1  NP_001269414.1  NP_006250.1  

    ENSEMBL proteins: 
     ENSP00000378945   ENSP00000264399   ENSP00000389038   ENSP00000439967  
    Reactome Protein details: Q13237

    PRKG2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Protein kinase G (PKG) 2
    Protein kinase G (PKG)
    Protein kinase G (PKG) family

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR018488 cNMP-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q13237

    ProtoNet protein and cluster: Q13237

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB000961 Protein kinase C-terminal domain
    IPB002374 cGMP-dependent protein kinase signature


    UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 cyclic nucleotide-binding domains
    Similarity: Contains 1 protein kinase domain


    PRKG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KGP2_HUMAN, Q13237
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding of cGMP results in enzyme activation

         Genatlas biochemistry entry for PRKG2:
    protein kinase,cGMD dependent,type II,87kDa,putatively involved in regulation of intestinal fluid secretion

         Enzyme Numbers (IUBMB): EC 2.7.11.121 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8607838
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004692cGMP-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    PRKG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRKG2:
     Decreased 12E8 and total tau p 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prkg2):
     adipose tissue  craniofacial  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     limbs/digits/tail  skeleton 

    PRKG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkg2tm1Pfe for PRKG2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKG2

    miRNA
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    miRTarBase miRNAs that target PRKG2:
    hsa-mir-1 (MIRT023857), hsa-mir-335-5p (MIRT018075)

    Block miRNA regulation of human, mouse, rat PRKG2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PRKG2:
    hsa-miR-877* hsa-miR-544 hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-548c-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidPRKG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKG2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PRKG2 (NM_006259)
    Sino Biological Human cDNA Clone for PRKG2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKG2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KGP2_HUMAN, Q13237: Apical cell membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----
    GO:0016324apical plasma membrane IEA--

    PRKG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKG2 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3Metabolism of nitric oxide
    Metabolism of nitric oxide
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.00
    eNOS activation and regulation0.00
    4Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    5Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKG2
        Cellular Effects of Sildenafil
    Sertoli-Sertoli Cell Junction Dynamics
    Sperm Motility
    Signaling in Gap Junctions
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    3 GeneGo (Thomson Reuters) Pathways for PRKG2
        Development EDNRB signaling
    Regulation of CFTR activity (norm and CF)
    NO-dependent CFTR activation (normal and CF)


    3 Reactome Pathways for PRKG2
        cGMP effects
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Ca2+ pathway


    5 Kegg Pathways  (Kegg details for PRKG2):
        Gap junction
    Circadian entrainment
    Long-term depression
    Olfactory transduction
    Salivary secretion


    PRKG2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKG2: 
              Hypertension in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRKG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKG2 (Q132373 ENSP000002643994) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYLKQ157463, ENSP000003534524I2D: score=2 STRING: ENSP00000353452
    PLCB3Q019703, ENSP000002792304I2D: score=1 STRING: ENSP00000279230
    PTSQ033933, ENSP000002803624I2D: score=1 STRING: ENSP00000280362
    LASP1Q148473, ENSP000003252404I2D: score=1 STRING: ENSP00000325240
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8607838
    GO:0007165signal transduction TAS8607838
    GO:0007596blood coagulation TAS--
    GO:0007623circadian rhythm ----
    GO:0032922circadian regulation of gene expression IEA--

    PRKG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKG2
      Browse compounds at ApexBio 

    Compounds for PRKG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 769662Potent AMPK activator[844499-71-4]
    Dorsomorphin dihydrochloridePotent and selective AMPK inhibitor[1219168-18-9]
    Metformin hydrochlorideActivator of LKB1/AMPK; antidiabetic agent[1115-70-4]
    PT 1AMPK activator[331002-70-1]

    2 HMDB Compounds for PRKG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for PRKG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 74.7 52 18728399 (3), 18031684 (3), 15722341 (3), 19543319 (3) (see all 18)
    enterotoxin 63.1 1 10864932 (1)
    guanylate 52.3 4 12011439 (1), 14988827 (1), 17684063 (1), 11444148 (1)
    nitric oxide 38 5 18728399 (2), 10593861 (1), 17684063 (1), 18514181 (1)
    bicarbonate 15.1 1 11444148 (1)
    calcium 12.9 1 10769198 (1)



    PRKG2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKG2 gene (6 alternative transcripts): 
    NM_001282480.1  NM_001282481.1  NM_001282482.1  NM_001282483.1  NM_001282485.1  NM_006259.2  

    Unigene Cluster for PRKG2:

    Protein kinase, cGMP-dependent, type II
    Hs.570833  [show with all ESTs]
    Unigene Representative Sequence: NM_006259
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395578(uc011cch.1) ENST00000509169 ENST00000509474 ENST00000456882
    ENST00000264399(uc011ccf.1 uc011ccg.1 uc003hmh.2) ENST00000418486
    ENST00000545647
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    7 qRT-PCR Assays for microRNAs that regulate PRKG2:
    hsa-miR-877* hsa-miR-544 hsa-miR-369-3p hsa-miR-374b hsa-miR-374a hsa-miR-548c-3p hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidPRKG2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PRKG2 (NM_006259)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKG2
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    Additional mRNA sequence: 

    AK296979.1 AK297673.1 AK316140.1 D70899.1 X94612.1 

    2 DOTS entries:

    DT.407659  DT.121276345 

    11 AceView cDNA sequences:

    X94612 BQ232970 NM_006259 BX101259 BX641735 D70899 AI005557 BX508960 
    AI827981 AA913837 AI383235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKG2 expression in normal human tissues (normalized intensities)      PRKG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCAGGGA
    PRKG2 Expression
    About this image


    PRKG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    PRKG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570833

    UniProtKB/Swiss-Prot: KGP2_HUMAN, Q13237
    Tissue specificity: Highly concentrated in brain, lung and intestinal mucosa

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKG2: 
              Hypertension in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PRKG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKG2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkg21 , 5 protein kinase, cGMP-dependent, type II1, 5 88.76(n)1
    96.85(a)1
      5 (48.35 cM)5
    190921  NM_008926.41  NP_032952.31 
     989297735 
    chicken
    (Gallus gallus)
    Aves PRKG21 protein kinase, cGMP-dependent, type II 76.38(n)
    80.93(a)
      428753  XM_004941095.1  XP_004941152.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKG26
    protein kinase, cGMP-dependent, type II
    78(a)
    1 ↔ 1
    5(42419469-42477035)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845593.12   -- 73.98(n)    BX845593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkg21 protein kinase, cGMP-dependent, type II 68.38(n)
    70.09(a)
      100125912  NM_001105279.1  NP_001098749.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta for3
    Pkg21D1
    protein amino acid phosphorylation
    protein serine/threonine more3
    cGMP-dependent protein kinase 21D1
    52(a)
    (best of 3)3
    54.56(n)1
    51.77(a)1
      332531  NM_057865.41  NP_477213.11 
    worm
    (Caenorhabditis elegans)
    Secernentea egl-43
    pkg-11
    cyclic-GMP-dependent protein kinase3
    pkg-11
    44(a)3
    55.29(n)1
    49.44(a)1
      IV(1848075-1879944)3
    1769911  NM_067740.41  NP_500141.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK16
    TPK36
    (see all 3)
    cAMP-dependent protein kinase catalytic subunit; p...
    cAMP-dependent protein kinase catalytic subunit; p...
    (see all 3)
    36(a)
    35(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(109966-111159) YJL164C
    XI(134509-135705) YKL166C


    ENSEMBL Gene Tree for PRKG2 (if available)
    TreeFam Gene Tree for PRKG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKG2 gene
    PRKX2  PRKACG2  PRKACA2  PRKG12  PRKACB2  
    Selected SIMAP similar genes for PRKG2 using alignment to 3 protein entries:     KGP2_HUMAN (see all proteins) (see all similar genes):
    MARK4    PRKG1    KIN27    PRKACB    PRKACA    PRKY
    RPS6KA2    PRKX    PRKCZ    PRKACG    STK32A    PHKG1
    SGK2    RPS6KB2    MAPK8    PDPK2    PkB-like 1    RPS6KA3

    PRKG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKG2 (see all 2550)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406094
    A colorectal adenocarcinoma sample4--see VAR_0406092 W R mis40--------
    rs1447065091,2
    C--82009524(+) AATCCC/TGGAAC 1 -- ds50010--------
    rs37968041,2
    C,F,A,H--82009707(+) GGAGAG/TTGCAA 1 -- ds500129Minor allele frequency- T:0.42EA NA NS WA CSA 4391
    rs1466877201,2
    --82009734(+) ATGCTA/GTTGTC 1 -- ds50010--------
    rs1158668851,2
    C,F--82009785(+) CCTGTC/TTTAAC 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1819811541,2
    --82009837(+) AAAAGC/TGCTAT 1 -- ut310--------
    rs1402586501,2
    C--82009904(+) TTAACA/GATGAT 1 -- ut310--------
    rs1148008961,2
    C--82009941(+) CAACTA/CTCACA 1 -- ut310--------
    rs170050511,2
    C,F,H--82010007(+) TATATT/CTTCCT 1 -- ut31 trp312Minor allele frequency- C:0.05NA NS EA WA 1340
    rs1871993051,2
    --82010017(+) TTTCTA/GTTTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKG2 (82009837 - 82136218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRKG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2526820CNV Deletion19546169
    esv2657932CNV Deletion23128226
    esv22713CNV Loss19812545
    nsv829984CNV Gain17160897

    Human Gene Mutation Database (HGMD): PRKG2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKG2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601591    OMIM disorders: --

    16 diseases for PRKG2:    About MalaCards
    secretory diarrhea    hyperphenylalaninemia    diarrhea    gout
    myeloproliferative disorder    cystic fibrosis    short stature    alcohol dependence
    mental retardation    hypertension    hiv-1    lung cancer
    endotheliitis    breast cancer    malaria    neuronitis


    PRKG2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PRKG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 55.7 5 9755058 (1), 12011439 (1), 10864932 (1), 9020133 (1) (see all 5)

    Genetic Association Database (GAD): PRKG2
    Human Genome Epidemiology (HuGE) Navigator: PRKG2 (4 documents)

    Export disorders for PRKG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKG2 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with PRKG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. (PubMed id 7498513)1, 2, 3, 9 Fujii M....Ayusawa D. (FEBS Lett. 1995)
    2. Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. (PubMed id 8607838)1, 2, 9 Orstavik S.... Sandberg M. (Biochem. Biophys. Res. Commun. 1996)
    3. Characterization of the gene encoding the human type II cGMP- dependent protein kinase. (PubMed id 9535793)1, 2, 9 Witczak O....Sandberg M. (Biochem. Biophys. Res. Commun. 1998)
    4. The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. (PubMed id 18678579)1, 4, 9 Chang S.J....Lai H.M. (Ann. Rheum. Dis. 2009)
    5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PubMed id 19343178)1, 4 Soranzo N....Deloukas P. (PLoS Genet. 2009)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    9. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. (PubMed id 18606955)1, 4 Schumann G....Mann K. (Arch. Gen. Psychiatry 2008)
    10. Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. (PubMed id 19543319)1, 9 Swartling F.J....Westermark B. (Oncogene 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5593 HGNC: 9416 AceView: PRKG2 Ensembl:ENSG00000138669 euGenes: HUgn5593
    ECgene: PRKG2 Kegg: 5593 H-InvDB: PRKG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKG2 gene:
    Search GeneIP for patents involving PRKG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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