Aliases for PRKG2 Gene
External Ids for PRKG2 Gene
Previous GeneCards Identifiers for PRKG2 Gene
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PRKG2 Gene
PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include Chromosome 4Q21 Deletion Syndrome and Mast-Cell Sarcoma. Among its related pathways are eNOS activation and regulation and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is PRKG1.
UniProtKB/Swiss-Prot for PRKG2 Gene
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1alpha and PKG1beta.