Aliases for PRKG2 Gene
External Ids for PRKG2 Gene
Previous GeneCards Identifiers for PRKG2 Gene
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for PRKG2 Gene
PRKG2 (Protein Kinase, CGMP-Dependent, Type II) is a Protein Coding gene. Diseases associated with PRKG2 include chromosome 4q21 deletion syndrome and hyperphenylalaninemia. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is PRKACA.
Protein Kinase G (PKG) is a cyclic GMP-dependent protein serine/threonine kinase that phosphorylates a variety of biological targets. There are two subtypes of PKG: PKG1 and PKG2 and, due to alternative exon splicing, two isoforms of PKG1 - PKG1alpha and PKG1beta.