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PRKG1 Gene

protein-coding   GIFtS: 69
GCID: GC10P052751

Protein Kinase, CGMP-Dependent, Type I


(Previous symbols: PRKGR1B, PRKG1B)
  See PRKG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CGMP-Dependent, Type I1 2     PKG2
PRKG1B1 2 3 5     cGK2
PRKGR1B1 2 3 5     cGKI-BETA2
cGK12 3     cGKI-alpha2
cGKI2 3     CGMP-Dependent Protein Kinase 12
CGK 12 3     Protein Kinase, CGMP-Dependent, Regulatory, Type I, Beta2
EC 2.7.11.123 8     PRKGR1A3
AAT82 5     CGMP-Dependent Protein Kinase I3
12     EC 2.7.118

External Ids:    HGNC: 94141   Entrez Gene: 55922   Ensembl: ENSG000001855327   OMIM: 1768945   UniProtKB: Q139763   

Export aliases for PRKG1 gene to outside databases

Previous GC identifers: GC10P051594 GC10P051702 GC10P052643 GC10P052095 GC10P052421 GC10P046729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKG1 Gene:
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG
isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many
signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble
Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4,
PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating
cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet
aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle,
platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta
have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and
autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
(provided by RefSeq, Sep 2011)

GeneCards Summary for PRKG1 Gene:
PRKG1 (protein kinase, cGMP-dependent, type I) is a protein-coding gene. Diseases associated with PRKG1 include aortic aneurysm, familial thoracic 8, and aortic aneurysm, familial thoracic 4. GO annotations related to this gene include cGMP-dependent protein kinase activity and calcium channel regulator activity. An important paralog of this gene is PRKX.

UniProtKB/Swiss-Prot: KGP1_HUMAN, Q13976
Function: Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling
pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins.
Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the
contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated
by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression,
feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon
guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is
mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium,
and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular
calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca(2+) release from
intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which
leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential
channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of
NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA).
Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA
translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain
phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a
number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth
muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the
matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates
vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle

Gene Wiki entry for PRKG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKG1 gene promoter:
         E2F-4   E2F-3a   TBP   E2F-1   E2F   TFIID   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKG1 promoter sequence
   Search Chromatin IP Primers for PRKG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

PRKG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKG1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P052751:  view genomic region     (about GC identifiers)

Start:
52,750,945 bp from pter      End:
54,058,110 bp from pter
Size:
1,307,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KGP1_HUMAN, Q13976 (See protein sequence)
Recommended Name: cGMP-dependent protein kinase 1  
Size: 671 amino acids; 76364 Da
Subunit: Isoform alpha: parallel homodimer or heterodimer and also heterotetramer. Interacts directly with
PPP1R12A. Non-covalent dimer of dimer of PRKG1-PRKG1 and PPP1R12A-PPP1R12A. This interaction targets PRKG1 to
stress fibers to mediate smooth muscle cell relaxation and vasodilation in responses to rises in cGMP. Isoform
beta: antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin,
CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with MRVI1. Forms a stable
complex with ITPR1, MRVI1, and isoform beta of PRKG1. Interacts with TRPC7 (via ankyrin repeat domain). Isoform
alpha interacts with RGS2. Interacts with GTF2I
Selected PDB 3D structures from and Proteopedia for PRKG1 (see all 7):
1ZXA (3D)        3NMD (3D)        3OCP (3D)        3OD0 (3D)        3OGJ (3D)        4KU7 (3D)    
Secondary accessions: E2PU10 P14619 Q5JSJ6 Q6P5T7
Alternative splicing: 2 isoforms:  Q13976-1   Q13976-2, P14619-1   

Explore the universe of human proteins at neXtProt for PRKG1: NX_Q13976

Explore proteomics data for PRKG1 at MOPED

Post-translational modifications: 

  • Autophosphorylation increases kinase activity1
  • 65 kDa monomer is produced by proteolytic cleavage (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKG1 (Q13976) (see all 27)
     GFNWEGL  LYRTFKD  LGILMYE  IQKHKWF 


    See PRKG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091982.1  NP_006249.1  

    ENSEMBL proteins: 
     ENSP00000363097   ENSP00000363092   ENSP00000363087   ENSP00000363086   ENSP00000384200  
    Reactome Protein details: Q13976

    PRKG1 Human Recombinant Protein Products:

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    Novus Biologicals PRKG1 Proteins
    Novus Biologicals PRKG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRKG1

     
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    antibodies-online proteins for PRKG1 (5 products) 

     
    antibodies-online peptides for PRKG1

    PRKG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKG1
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    antibodies-online antibodies for PRKG1 (51 products) 

    PRKG1 Assay Products:

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    GenScript Custom Assay Services for PRKG1
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    Cloud-Clone Corp. ELISAs for PRKG1
    Cloud-Clone Corp. CLIAs for PRKG1
    Search eBioscience for ELISAs for PRKG1 
    antibodies-online kits for PRKG1 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Protein kinase G (PKG) 1
    Protein kinase G (PKG)
    Protein kinase G (PKG) family

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR018488 cNMP-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q13976

    ProtoNet protein and cluster: Q13976

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB000961 Protein kinase C-terminal domain
    IPB002374 cGMP-dependent protein kinase signature


    UniProtKB/Swiss-Prot: KGP1_HUMAN, Q13976
    Domain: Composed of an N-terminal leucine-zipper domain followed by an autoinhibitory domain, which mediate
    homodimer formation and inhibit kinase activity, respectively. Next, two cGMP-binding domains are followed by the
    catalytic domain at the C-terminus. Binding of cGMP to cGMP-binding domains results in a conformational change
    that activates kinase activity by removing the autoinhibitory domain from the catalytic cleft leaving the
    catalytic domain free to phosphorylate downstream substrates. Isoforms alpha and beta have identical cGMP-binding
    and catalytic domains but differ in their leucine zipper and autoinhibitory sequences and therefore differ in
    their dimerization substrates and kinase enzyme activity
    Domain: Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the
    leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 2 cyclic nucleotide-binding domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KGP1_HUMAN, Q13976
    Function: Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling
    pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins.
    Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the
    contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated
    by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression,
    feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon
    guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is
    mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium,
    and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular
    calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca(2+) release from
    intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which
    leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential
    channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of
    NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA).
    Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA
    translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain
    phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a
    number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth
    muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the
    matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates
    vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: In the absence of cGMP, PRKG1 activity is suppressed by autoinhibitory contacts

         Genatlas biochemistry entry for PRKG1:
    protein kinase,cGMP-dependent,regulatory,type I,with two alternatively spliced isoforms,1 alpha predominantly
    expressed in lung,placenta,1 beta in bladder,uterus,adrenals,fallopian tube

         Enzyme Numbers (IUBMB): EC 2.7.11.121 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004692cGMP-dependent protein kinase activity IDA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005246calcium channel regulator activity IDA--
         
    Find genes that share ontologies with PRKG1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKG1:
     Decreased nuclei size in G2M  Decreased substrate adherent c 

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Prkg1):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     nervous system  normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with PRKG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKG1: Prkg1tm2.1Naw Prkg1tm1Naw Prkg1tm1Hfm

       genOway: Develop your customized and physiologically relevant rodent model for PRKG1

    miRNA
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    Block miRNA regulation of human, mouse, rat PRKG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKG1 (see all 40):
    hsa-miR-4291 hsa-miR-15a hsa-miR-29a hsa-miR-218 hsa-miR-1276 hsa-miR-424 hsa-miR-298 hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidPRKG1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKG1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRKG1 (NM_006258)
    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for PRKG1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KGP1_HUMAN, Q13976: Cytoplasm (By similarity). Note=Colocalized with TRPC7 in the plasma membrane (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    golgi apparatus2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16990611

    Find genes that share ontologies with PRKG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKG1 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    4Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    5Olfactory Signaling Pathway
    Olfactory transduction0.82


    Find genes that share SuperPaths with PRKG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKG1 (see all 7)
        Cellular Effects of Sildenafil
    Sertoli-Sertoli Cell Junction Dynamics
    eNOS Signaling
    Netrin Signaling
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for PRKG1
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for PRKG1
        Development EDNRB signaling
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    1 BioSystems Pathway for PRKG1
        MicroRNAs in cardiomyocyte hypertrophy

    1 Reactome Pathway for PRKG1
        Ca2+ pathway


    Selected Kegg Pathways  (Kegg details for PRKG1) (see all 6):
        Vascular smooth muscle contraction
    Gap junction
    Circadian entrainment
    Long-term depression
    Olfactory transduction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKG1: 
              Hypertension in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKG1 (Q139761, 2, 3 ENSP000003630924) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138731, 2, 3, ENSP000003637084EBI-3952014,EBI-527196 MINT-7289555 MINT-7289591 I2D: score=2 STRING: ENSP00000363708
    SMAD4Q134852, 3, ENSP000003415514MINT-7289576 I2D: score=2 STRING: ENSP00000341551
    GKAP1Q5VSY03, ENSP000003655504I2D: score=2 STRING: ENSP00000365550
    GTF2IP783473, ENSP000003225424I2D: score=2 STRING: ENSP00000322542
    NPR1P160663, ENSP000003576694I2D: score=2 STRING: ENSP00000357669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006468protein phosphorylation TAS10851246
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0016358dendrite development IEA--

    Find genes that share ontologies with PRKG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKG1
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRKG1 (KGP1)

    2 HMDB Compounds for PRKG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for PRKG1 (Protein kinase G (PKG) 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    Rp-8-CPT-cGMPS
    InhibitorInhibition7851503

    Selected Novoseek inferred chemical compound relationships for PRKG1 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-phosphoglycerate 86.6 45 18078348 (3), 11782484 (2), 18288812 (2), 2324090 (1) (see all 20)
    hpaii 74 4 8529956 (1), 9546367 (1), 18070446 (1), 16776996 (1)
    cgmp 71.9 185 19008225 (7), 17329019 (5), 10724174 (5), 15711749 (4) (see all 43)
    1,3-bisphosphoglycerate 68.4 3 19422062 (1), 10809925 (1), 15951330 (1)
    kt 5823 60.1 4 7673208 (1), 20332625 (1), 7506258 (1), 9798908 (1)
    glyceraldehyde 3-phosphate 55.4 19 9187498 (1), 11681208 (1), 15803666 (1), 9579064 (1) (see all 12)
    8-bromo cgmp 46.9 3 7673208 (1), 10085070 (1), 8831498 (1)
    nitric oxide 41.6 46 19095646 (3), 19307986 (3), 7673208 (2), 10355605 (2) (see all 26)
    guanidine hydrochloride 35.3 7 7492597 (2), 9655344 (1), 16430920 (1), 16028018 (1)
    hypoxanthine 31.9 5 8100140 (1), 1973172 (1), 2018791 (1), 8597608 (1) (see all 5)



    Find genes that share compounds with PRKG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKG1 gene (2 alternative transcripts): 
    NM_001098512.2  NM_006258.3  

    Unigene Cluster for PRKG1:

    Protein kinase, cGMP-dependent, type I
    Hs.407535  [show with all ESTs]
    Unigene Representative Sequence: NM_001098512
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373985(uc001jjm.3) ENST00000373980(uc001jjn.2 uc001jjo.3)
    ENST00000373976 ENST00000373975(uc009xow.2) ENST00000401604(uc010qhp.2)

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    hsa-miR-4291 hsa-miR-15a hsa-miR-29a hsa-miR-218 hsa-miR-1276 hsa-miR-424 hsa-miR-298 hsa-miR-1183
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    Additional mRNA sequence: 

    AK093436.1 AK300110.1 AK313416.1 BC062688.1 BC127090.1 D45864.1 EF560730.1 Y07512.1 

    6 DOTS entries:

    DT.109672  DT.314316  DT.100668620  DT.109673  DT.100668793  DT.121258434 

    6 AceView cDNA sequences:

    BM721298 AL603209 BX503850 CB958569 Y07512 NM_006258 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGAGTGGG
    PRKG1 Expression
    About this image


    PRKG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Floor Plate
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
    PRKG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407535

    UniProtKB/Swiss-Prot: KGP1_HUMAN, Q13976
    Tissue specificity: Primarily expressed in lung and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKG1: 
              Hypertension in human mouse rat
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKG1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkg11 , 5 protein kinase, cGMP-dependent, type I1, 5 89.09(n)1
    93(a)1
      19 (25.17 cM)5
    190911  NM_001013833.31  NP_001013855.11 
     305675515 
    chicken
    (Gallus gallus)
    Aves PRKG11 protein kinase, cGMP-dependent, type I 86.38(n)
    93.09(a)
      423682  XM_003641459.2  XP_003641507.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRKG16
    protein kinase, cGMP-dependent, type I
    99(a)
    1 ↔ 1
    GL343268.1(120324-241900)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.49022 Xenopus laevis transcribed sequence with strong similarity more 90.65(n)    BJ068678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639552 similar to protein kinase, cGMP-dependent, type I 79.22(n)   394005  BC054581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta for1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    foraging1
    60(a)
    (best of 3)3
    60.27(n)1
    62.82(a)1
      448171  NM_058140.31  NP_477488.11 
    worm
    (Caenorhabditis elegans)
    Secernentea egl-43 cyclic-GMP-dependent protein kinase 48(a)   IV(1848075-1879944)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK26
    TPK16
    (see all 3)
    cAMP-dependent protein kinase catalytic subunit; p...
    cAMP-dependent protein kinase catalytic subunit; p...
    (see all 3)
    36(a)
    36(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XVI(166256-167398) YPL203W
    X(109966-111159) YJL164C


    ENSEMBL Gene Tree for PRKG1 (if available)
    TreeFam Gene Tree for PRKG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKG1 gene
    PRKX2  PRKACG2  PRKG22  PRKACA2  PRKACB2  
    Selected SIMAP similar genes for PRKG1 using alignment to 5 protein entries:     KGP1_HUMAN (see all proteins) (see all similar genes):
    MARK4    PRKG2    PRKX    PRKACG    PRKACA    PRKY
    KIN27    RPS6KA2    PRKCZ    RPS6KB2    PRKACB    DKFZp781N0293
    SGK3    SGKL    STK32A    RPS6KB1    RPS6KA3    SGK1

    Find genes that share paralogs with PRKG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKG1 (see all 27916)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0704344
    Aortic aneurysm, familial thoracic 8 (AAT8)4--see VAR_0704342 R Q mis40--------
    rs1812131801,2
    Cuntested154080268(+) ATTTCA/C/TTCCTC 2 -- int10--------
    rs353868261,2
    C--46733190(+) TCAGG-/AAAAAA 1 -- int10--------
    rs1405461661,2
    C--46851920(+) AAAAA-/CAAACT 2 -- int10--------
    rs1999835901,2
    --46861537(+) CAGCC-/TCAAAA 2 -- int10--------
    rs1908644721,2
    C--46864456(+) TTTATA/TTATAA 2 -- int10--------
    rs1830621591,2
    --46864462(+) TATAAA/TTATTT 2 -- int10--------
    rs37402921,2
    C,F,A,H--46891184(-) CAAAAA/CAAAAA 2 -- int18Minor allele frequency- C:0.37NS EA NA WA 426
    rs759598801,2
    C--46891184(+) TTTTT-/G/GTTT
            
    TGCTG
    2 -- int10--------
    rs1383301461,2
    --46908657(+) GGTAT-/ACAC  
            
    ACACA
    2 -- int10--------

    HapMap Linkage Disequilibrium report for PRKG1 (52750945 - 53000945 bp, first 250kb of PRKG1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKG1 (see all 80):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736718CNV Deletion23290073
    esv2672425CNV Deletion23128226
    esv2668699CNV Deletion23128226
    esv2736795CNV Deletion23290073
    esv2660828CNV Deletion23128226
    esv2665031CNV Deletion23128226
    dgv140e199CNV Deletion23128226
    esv2736696CNV Deletion23290073
    esv1485951CNV Deletion17803354
    esv2621844CNV Deletion19546169

    Human Gene Mutation Database (HGMD): PRKG1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176894   
    OMIM disorders: 615436  
    UniProtKB/Swiss-Prot: KGP1_HUMAN, Q13976
  • Aortic aneurysm, familial thoracic 8 (AAT8) [MIM:615436]: A disease characterized by permanent dilation
    of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a
    characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which
    there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of
    basophilic ground substance. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for PRKG1:    
    About MalaCards
    aortic aneurysm, familial thoracic 8    aortic aneurysm, familial thoracic 4    phosphoglycerate kinase deficiency    intraductal papilloma
    erdheim-chester disease    hemangioma


    Find genes that share disorders with PRKG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKG1 gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgk deficiency 95.8 38 7679780 (3), 7603527 (3), 8998855 (3), 16740138 (3) (see all 17)
    enzymopathy 63.9 2 16987707 (1), 15555758 (1)
    anemia hemolytic 62.7 12 16740138 (2), 8043870 (2), 9744480 (1), 7577653 (1) (see all 10)
    myoglobinuria, recurrent 60.7 2 7679780 (1), 1591023 (1)
    enzyme deficiency 54.9 1 8795843 (1)
    vesicular stomatitis 51.9 4 11090053 (1), 12409263 (1), 11044122 (1), 15966018 (1)
    papilloma intraductal 43.1 1 7911274 (1)
    myopathy 40.9 7 7603527 (2), 9744480 (1), 20151463 (1), 8043870 (1) (see all 5)
    myeloproliferative disorders 40.7 1 7911034 (1)
    myelodysplastic syndromes 38.6 3 8100140 (1), 8101108 (1), 1862109 (1)

    Genetic Association Database (GAD): PRKG1
    Human Genome Epidemiology (HuGE) Navigator: PRKG1 (15 documents)

    Export disorders for PRKG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKG1 gene, integrated from 10 sources (see all 398):
    (articles sorted by number of sources associating them with PRKG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. (PubMed id 2792381)1, 2, 3 Sandberg M.... Jahnsen T. (FEBS Lett. 1989)
    2. Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). (PubMed id 9192852)1, 2, 9 Orstavik S.... Sandberg M. (Genomics 1997)
    3. cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase. (PubMed id 8613202)1, 2, 9 Tamura N.... Nakao K. (Hypertension 1996)
    4. Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity. (PubMed id 15917860)1, 4, 9 Zakharkin S.O....Allison D.B. (Int J Obes (Lond) 2005)
    5. Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. (PubMed id 18782776)1, 2, 9 Sharma A.K.... Rigby A.C. (J. Biol. Chem. 2008)
    6. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. (PubMed id 23910461)1, 2 Guo D.C.... Milewicz D.M. (Am. J. Hum. Genet. 2013)
    7. Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. (PubMed id 21907864)1, 4 Ferreira M.A....Thompson P.J. (Lancet 2011)
    8. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. (PubMed id 21402151)1, 2 Yuasa K.... Tsuji A. (Cell. Signal. 2011)
    9. Co-crystal structures of PKG Ibeta (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. (PubMed id 21526164)1, 2 Kim J.J.... Kim C. (PLoS ONE 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5592 HGNC: 9414 AceView: PRKG1 Ensembl:ENSG00000185532 euGenes: HUgn5592
    ECgene: PRKG1 Kegg: 5592 H-InvDB: PRKG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKG1 gene:
    Search GeneIP for patents involving PRKG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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