 |
 | Services
| |
 |
Aliases &
Descriptions
for PRKDC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| DNA-PKcs 1, 2, 3 | | DNAPK 1, 2 | | DNPK1 1, 2, 3, 5 | | EC 2.7.11.1 3 | | HYRC 2, 3 | | HYRC1 2, 3, 5 | | XRCC7 1, 2 | | p350 1, 2 | | p460 3 |
| | | Descriptions |
|---|
| DNA-PK catalytic subunit 3 | hyper-radiosensitivity of murine scid mutation,
complementing 1 2 | | protein kinase, DNA-activated, catalytic polypeptide 2 |
|
| |
Search outside databases for aliases for PRKDC genePrevious GC identifers: GC08P047830 GC08M048689 GC08M048408 GC08M048735 |
Summaries
for PRKDC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PRKDC:
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein
kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded
by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and
relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must
be bound to DNA to express its catalytic properties.[supplied by OMIM]
UniProtKB/Swiss-Prot: PRKDC_HUMAN, P78527Function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved
in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J
recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of
hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis
(DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation
step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid
the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes,
suggesting a further role in the maintenance of telomeric stability and the prevention of
chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate
consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby
regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA,
c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC
and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of
supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent
on C1DGene Wiki entry for PRKDC |
Genomic Location
for PRKDC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the PRKDC gene 
Entrez Gene cytogenetic band: 8q11 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8q11PRKDC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M048848:
(about GC identifiers)
Start:
|
48,848,222 bp from pter |
End:
|
49,035,296 bp from pter |
Size:
|
187,075 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008183.18
| Proteins
for PRKDC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PRKDC_HUMAN, P78527 (See
protein sequence)Recommended Name: DNA-dependent protein kinase catalytic subunit Size: 4128 amino acids; 469089 Da
Subunit: DNA-PK is a heterotrimer of PRKDC and the Ku p70-p86 (XRCC6-XRCC5) dimer. Formation of
this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku
heterodimer, but it can also bind to and be activated by free DNA. Interacts with
DNA-PKcs-interacting protein (KIP) with the region upstream the kinase domain. PRKDC alone also
interacts with and phosphorylates DCLRE1C, thereby activating the latent endonuclease activity of
this protein. Interacts with C1D
Subcellular location: Nucleus
Secondary accessions: P78528 Q13327 Q13337 Q14175 Q59H99 Q7Z611 Q96SE6 Q9UME3Alternative splicing: 2 isoforms: P78527-1 P78527-2 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Autophosphorylated on Thr-2609, Thr-2638
and Thr-2647. Thr-2609 is a DNA damage-inducible phosphorylation site (inducible with ionizing
radiation, IR). Autophosphorylation induces a conformational change that leads to remodeling of
the DNA-PK complex, requisite for efficient end processing and DNA repair1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001075109.1 NP_008835.5
ENSEMBL proteins: ENSP00000313420 ENSP00000345182
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PRKDC:  | Invitrogen Antibodies for PRKDC |  | Millipore Mono- and Polyclonal Antibodies for the study of PRKDC |  | Sigma-Aldrich Antibodies for PRKDC |  | R&D Systems Antibodies for PRKDC (DNA-PKcs) |  | Cell Signaling Technology (CST) Antibodies for PRKDC (DNA-PK) |  | Antibodies from Abcam (DNA PKcs), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (PRKDC) |  | Novus Biologicals Antibodies for PRKDC |
Assays for PRKDC: | Protein
Domains/
Families
for PRKDC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P78527
ProtoNet protein and cluster: P78527 4 Blocks protein families: IPB000357 HEAT repeat IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003151 PIK-related kinase IPB012582 NUC194
UniProtKB/Swiss-Prot: PRKDC_HUMAN, P78527Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 FAT domainSimilarity: Contains 1 FATC domainSimilarity: Contains 2 HEAT repeatsSimilarity: Contains 1 PI3K/PI4K domainSimilarity: Contains 3 TPR repeats | Gene Function
for PRKDC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006904
 Applied Biosystems Silencer® siRNAs for PRKDC
Sigma-Aldrich siRNA and siRNA Panels for PRKDC
Sigma-Aldrich shRNA Panels and shRNA for PRKDC
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_006904
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006904
untagged cDNA clone in CMV expression vector: NM_006904
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_006904
UniProtKB/Swiss-Prot: PRKDC_HUMAN, P78527Function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved
in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J
recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of
hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis
(DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation
step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid
the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes,
suggesting a further role in the maintenance of telomeric stability and the prevention of
chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate
consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby
regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA,
c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC
and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of
supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent
on C1DCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by wortmannin. Activity of the enzyme seems to be attenuated by
autophosphorylationEnzyme Number (IUBMB): EC 2.7.11.1 Genatlas biochemistry entry for PRKDC:DNA dependent serine/threonine protein kinase catalytic subunit,dimerizing with Ku antigen (see
KUP70 (CLU),KUP80),involved in DNA double-strand break repair by end joining (non homologous
recombination) and V(D)J recombination,same as HYRC115/18 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Prkdc) (see all 18
):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for PRKDC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for PRKDC (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for PRKDC
5/60 Interacting proteins for PRKDC (ENSP000003134203 P785271, 2) via UniProtKB, MINT, and/or STRING (see all 60
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds
for PRKDC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
| | Sigma-Aldrich Small Molecules for PRKDC:
Inhibitor |
 Compounds for PRKDC available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| DMNB | DNA-dependent protein kinase inhibitor | [20357-25-9] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | NU 7026 | Selective DNA-dependent protein kinase inhibitor | [154447-35-5] | | Compound 401 | Selective DNA-PK and mTOR inhibitor | [168425-64-7] |
About this table
5  Novoseek chemical compound relationships for PRKDC gene
About this table
|
Transcripts
for PRKDC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006904
Sigma-Aldrich siRNA and siRNA Panels for PRKDC
Sigma-Aldrich shRNA Panels and shRNA for PRKDC
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_001081640 NM_006904 REFSEQ mRNAs for PRKDC gene (2 alternative transcripts): NM_001081640.1 NM_006904.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001081640 NM_006904
OriGene GFP tagged cDNA clone in CMV expression vector: NM_006904
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006904
untagged cDNA clone in CMV expression vector: NM_006904
Additional cDNA sequence: AB208860.1 AK022387.1 AK296833.1 BC017494.1 BC024963.1 BC037968.1 CR607506.1 U34994.3 U35835.1 U47077.5 24 DOTS entries: DT.447515 DT.91810315 DT.100798110 DT.100798105 DT.91724527 DT.86840995 DT.207420 DT.118545 DT.91986268 DT.95155071 DT.95261648 DT.99952979 DT.120635215 DT.120635274 DT.40194022 DT.91863895 DT.91926822 DT.92024383 DT.95073263 DT.95155076 DT.97822103 DT.100662770 DT.121449421 DT.40132575 24/489 AceView cDNA sequences (see all 489
):AL521287 CB111630 BP362147 AI435413 BQ072273 AI799494 BM747522 U47077 BM756081 CR607506 CB160397 BC024963 BQ223426 AV656425 CB850939 AA846794 AI810280 BQ687868 T35292 AW673866 BM665892 AI354543 AU125778 BG403059
 highest scoring ESTs for PRKDC:U34994 U47077 AA936954 AV727617 BX955969 AA037793 AA055286 AA113343 AA258602 AA298049 Unigene Cluster for PRKDC: Protein kinase, DNA-activated, catalytic polypeptide Hs.491682 [show with all ESTs]Unigene Representative Sequence: NM_006904
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PRKDC (see all 16
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41a | · | 41b | ^ | 42 | ^ | 43 | ^ | 44a | · | 44b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PRKDC
2 Ensembl transcripts including schematic representations: ENST00000314191
ENST00000338368
|
Expression
for PRKDC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PRKDC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PRKDC
1 / 2 / 3 9 probe-sets matching PRKDC gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCAGTCCCT
SOURCE GeneReport for Unigene cluster: Hs.491682
Expression variation in blood from EXPOLDB for PRKDC |
Orthologs
for PRKDC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PRKDC gene from 5/9 species (see all 9
)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
PRKDC1 |
-- |
protein kinase, DNA-activated, catalytic polypeptide |
85.28(n)
83.28(a) |
474176 NM_001006651.1 NP_001006652.1 |
chimpanzee
(Pan troglodytes) |
PRKDC1 |
-- |
protein kinase, DNA-activated, catalytic polypeptide |
99.61(n)
99.54(a) |
464165 XM_001147162.1 XP_001147162.1 |
cow
(Bos taurus) |
PRKDC1 |
-- |
protein kinase, DNA-activated, catalytic polypeptide |
78.89(n)
78.15(a) |
512740 XM_874222.2 XP_879315.2 |
rat
(Rattus norvegicus) |
Prkdc1 |
-- |
protein kinase, DNA activated, catalytic polypeptide |
80.91(n)
78.49(a) |
360748 XM_341020.3 XP_341021.3 |
mouse
(Mus musculus) |
Prkdc1, 5 |
16 (9.20 cM)5
|
protein kinase, DNA activated, catalytic polypeptide1, 5 |
81.23(n)1
79.37(a)1 |
190901 NM_011159.21 NP_035289.21
AB0006295 AB0051505 (see all 90) |
About this table Species with no ortholog for PRKDC
ENSEMBL Gene Tree for PRKDC | Paralogs
for PRKDC(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PRKDC gene
- ENSG000002055362 ENSG000001807472 ENSG000002056852 ENSG000002055352 SLC7A5P12 ENSG000002051522 ENSG000001573412 LOC5951012
- ENSG000002055342 ENSG000002056912 SMG12 MTOR2 ENSG000001857102
|
SNPs/Variants
for PRKDC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PRKDC (up to first 250kb)
|
Disorders & Mutations
for PRKDC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600899
7 Novoseek disease relationships for PRKDC gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ataxia telangiectasia |
78.16 |
19 |
19029686 (1), 15758953 (1), 18451257 (1), 18483401 (1) (see all 12) |
| severe combined immunodeficiency |
66.37 |
5 |
9205842 (1), 9539023 (1), 12695618 (1), 9380717 (1) |
| glioma |
30.87 |
2 |
19435898 (1), 18202016 (1) |
| tumors |
21.03 |
4 |
12670903 (1), 10629611 (1), 12377759 (1), 11096417 (1) |
| cancer |
18.87 |
3 |
16077955 (1), 17143500 (1), 19281848 (1) |
| glioblastoma |
18.56 |
1 |
10629611 (1) |
| melanoma |
0.00 |
2 |
16000590 (1), 15179184 (1) |
About this table
1 PharmGKB disease relationship for PRKDC geneAbout this table
Human Gene Mutation Database: PRKDC
Genetic Association Database: PRKDC
Human Genome Epidemiology Navigator: PRKDC (14 documents)
|
Medical News
for PRKDC(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PRKDC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/303 PubMed articles for PRKDC gene (see all 303
):- Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. (PubMed id 7638222)1, 2, 3, 4 Sipley J.D....Anderson C.W. (1995)
- Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J. (PubMed id 11418067)1, 3, 4 Anderson C.W....Allalunis-Turner M.J. (2001)
- MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. (PubMed id 9284934)1, 3, 4 Ladenburger E.M.... Knippers R. (1997)
- Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. (PubMed id 12231622)1, 3, 4 Chan D.W....Chen D.J. (2002)
- Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (PubMed id 15758953)1, 3, 4 Falck J.... Jackson S.P. (2005)
- XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. (PubMed id 16397295)3, 4 Levy N....Menissier-de Murcia J. (2006)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)3, 4 Nousiainen M.... Koerner R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. (PubMed id 15811628)3, 4 Wang J.... Yannone S.M. (2005)
- The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. (PubMed id 15936993)3, 4 Ma Y.... Lieber M.R. (2005)
|
Search for PRKDC
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRKDC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PRKDC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRKDC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for PRKDC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for PRKDC:
 | |
 | | | | |
 |
 |  |  | |
 | Antibodies & Assays for PRKDC (DNA-PK) |
| | | | | Tocris compounds for PRKDC |
|
 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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V3 here soon-try beta now
