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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRKD3 Gene

protein-coding GIFtS: 65
GCID: GC02M037477

protein kinase D3

(Previous names: protein kinase C, nu )
(Previous symbol: PRKCN)

Explore 11 diseases affiliated with
PRKD3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase D3¹ ²		PKC-NU²
PRKCN¹ ² ³ ⁵		PKD3²
EPK2¹ ² ³		NPKC-NU¹
Protein Kinase C, Nu¹ ²		Protein-Serine/Threonine Kinase²
Protein Kinase C Nu Type² ³		Serine/Threonine-Protein Kinase D3²
Protein Kinase EPK2² ³		NPKC-Nu¹
EC 2.7.11.13³ ⁸		EC 2.7.11⁸

External Ids:	HGNC: 9408¹	Entrez Gene: 23683²	Ensembl: ENSG00000115825⁷	OMIM: 607077⁵	UniProtKB: O94806³

Export aliases for PRKD3 gene to outside databases

Previous GC identifers: GC02M037389 GC02M037217

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKD3:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium

and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are

known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for

phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is

believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can

be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its

nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be

activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the

involvement of other PKC family members. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KPCD3_HUMAN, O94806

Function: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC.

Involved in resistance to oxidative stress (By similarity)

summary for PRKD3:

The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and

PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol

(DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel

signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs

contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a

role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an

autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of

homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are

localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity

of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli

including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress,

cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces

CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the

plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and

transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the

plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in

fundamental physiological processes including signal transduction, membrane trafficking, and cell survival,

migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and

suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the

trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in

regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also

have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only

a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine

cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRKD3 gene promoter:
Pbx1a AML1a Lmo2 POU6F1 (c2) Tal-1beta Evi-1 Gfi-1 Cart-1 ITF-2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKD3 promoter sequence

Search SABiosciences Chromatin IP Primers for PRKD3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p22.2 HGNC cytogenetic band: 2p21

PRKD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKD3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M037477: view genomic region (about GC identifiers)

Start:	37,477,645 bp from pter	End:	37,551,951 bp from pter
Size:	74,307 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KPCD3_HUMAN, O94806 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase D3

Size: 890 amino acids; 100471 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation

1 PDB 3D structure from and Proteopedia for PRKD3:

2D9Z (3D)

Secondary accessions: D6W587 Q53TR7 Q8NEL8

Alternative splicing: 2 isoforms: O94806-1 O94806-2

Explore the universe of human proteins at neXtProt for PRKD3: NX_O94806

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94806

4/31 DME Specific Peptides for PRKD3 (O94806) (see all 31)

IPNNCSG

VKVPHTF

HSYTRPT

LSHPWLQ

PRKD3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005804.1

ENSEMBL proteins:

ENSP00000368356 ENSP00000399540 ENSP00000398743 ENSP00000401839 ENSP00000234179

Human Recombinant Protein Products for PRKD3:

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	Novus Biologicals PRKD3 Proteins
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRKD3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0016020	membrane	IEA	--

PRKD3 for ontologies About GeneDecksing

PRKD3 Antibody Products:

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	Uscn Antibodies for PRKD3
	ThermoFisher Antibody for PRKD3

Assay Products for PRKD3:

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	GenScript Custom Assay Services for PRKD3
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	Uscn ELISAs and CLIAs for PRKD3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRKD3 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR020454 DAG/PE-bd

IPR011009 Kinase-like_dom

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry O94806

ProtoNet protein and cluster: O94806

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: KPCD3_HUMAN, O94806

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily

Similarity: Contains 1 PH domain

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KPCD3_HUMAN, O94806

Function: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC.

Involved in resistance to oxidative stress (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and

phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and

phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain

Enzyme Numbers (IUBMB): EC 2.7.11.13¹ ² EC 2.7.11²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004697	protein kinase C activity	IEA	--
GO:0005515	protein binding	IPI	17196367
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0042802	identical protein binding	IPI	17196367

PRKD3 for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for PRKD3:

Decreased focal adhesion (FA)	Decreased substrate adherent c	Decreased viability with RAF26	G0/1 arrest
Increased G1 DNA content

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prkd3):

limbs/digits/tail

skeleton

PRKD3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRKD3

miRNA Products:		OriGene 3'-UTR Clone: PRKD3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKD3
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKD3 (see all 58):
		hsa-miR-323-3p hsa-miR-582-3p hsa-miR-139-5p hsa-miR-301a hsa-miR-192 hsa-miR-548l hsa-miR-105 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: PRKD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKD3 (see all 4) OriGene shRNA RFP: PRKD3 OriGene siRNA: PRKD3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKD3
		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKD3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PRKD3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKD3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development VEGF signaling via VEGFR2 - generic cascades

	Development VEGF signaling via VEGFR2 - generic cascades	1.00			Development_VEGF signaling and activation	0.75
	Development VEGF signaling and activation	0.75			Development_VEGF signaling via VEGFR2 - generic cascades	0.51

G Protein Signaling Pathways

	G Protein Signaling Pathways	1.00			Signal transduction_cAMP signaling	0.44
	Signal transduction cAMP signaling	0.44

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

Cell adhesion_Gap junctions

Cell adhesion_Gap junctions

1.00

Cell adhesion Gap junctions

0.89

Signal transduction Erk Interactions: Inhibition of Erk

Signal transduction Erk Interactions: Inhibition of Erk

1.00

Signal transduction_Erk Interactions- Inhibition of Erk

0.92

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for PRKD3 (see all 8)

	Transcription Transcription factor Tubby signaling pathways
	Development VEGF signaling and activation
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Cell adhesion Gap junctions
	Immune response Function of MEF2 in T lymphocytes

1 R&D Systems Pathway for PRKD3

Adipocytokines & Insulin Signaling

1 Cell Signaling Technology (CST) Pathway for PRKD3

Ca, cAMP and Lipid Signaling

5/7 GeneGo (Thomson Reuters) Pathways for PRKD3 (see all 7)

	Signal transduction Erk Interactions- Inhibition of Erk
	Development VEGF signaling via VEGFR2 - generic cascades
	Signal transduction cAMP signaling
	Transcription Transcription factor Tubby signaling pathways
	Development VEGF signaling and activation

3 BioSystems Pathways for PRKD3

	G Protein Signaling Pathways
	IL-4 signaling Pathway
	miRs in Muscle Cell Differentiation

PRKD3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRKD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/17 Interacting proteins for PRKD3 (O94806^{1, 2, 3} ENSP00000234179⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VAMP2	P63027¹^,³, ENSP00000314214⁴	EBI-1255366,EBI-520113 I2D: score=2 STRING: ENSP00000314214
NUDT3	O95989²^,³, ENSP00000351650⁴	MINT-8264955 I2D: score=2 STRING: ENSP00000351650
GSK3A	P49840³, ENSP00000222330⁴	I2D: score=2 STRING: ENSP00000222330
CHM	P24386³, ENSP00000350386⁴	I2D: score=1 STRING: ENSP00000350386
KPNB1	Q14974³, ENSP00000290158⁴	I2D: score=1 STRING: ENSP00000290158

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	TAS	10231560
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	TAS	10231560
GO:0035556	intracellular signal transduction	IEA	--

PRKD3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRKD3 for compounds About GeneDecksing

EMD Millipore small molecules for PRKD3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PRKD3 available from Tocris Bioscience About this table

Compound	Action	CAS #
CID 755673	Selective protein kinase D inhibitor	[521937-07-5]

10/846 HMDB Compounds for PRKD3 (see all 846) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--

2 Novoseek chemical compound relationships for PRKD3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	62.8	2	17077180 (1), 16380377 (1)
serine	59.2	3	17077180 (1), 12506120 (1), 16380377 (1)

Search CenterWatch for drugs/clinical trials and news about PRKD3 / KPCD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRKD3 gene:

NM_005813.3

Unigene Cluster for PRKD3:

Protein kinase D3

Hs.660757 [show with all ESTs]

Unigene Representative Sequence: NM_005813

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379066(uc002rqd.3) ENST00000469275(uc002rqe.1) ENST00000452104

ENST00000443977 ENST00000494667(uc002rqf.1) ENST00000475912 ENST00000443187

ENST00000464552 ENST00000477132 ENST00000234179

miRNA Products:		OriGene 3'-UTR Clone: PRKD3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKD3
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKD3 (see all 58):
		hsa-miR-323-3p hsa-miR-582-3p hsa-miR-139-5p hsa-miR-301a hsa-miR-192 hsa-miR-548l hsa-miR-105 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: PRKD3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKD3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKD3

Additional cDNA sequence:

AB015982.2 AK027585.1 BC012820.2 BC030706.2 Z25429.1

16 DOTS entries:

DT.448307 DT.99942189 DT.99935034 DT.121001680 DT.40285021 DT.121001603 DT.92427103 DT.100749416

DT.121001596 DT.121001621 DT.75191011 DT.92427104 DT.100737529 DT.101972013 DT.92427105 DT.75106802

24/171 AceView cDNA sequences (see all 171):

AL701262 AI189360 AI984594 AA286796 BM801533 AL039541 BM728254 BU173084

AI583590 BC012820 AI972133 AI745310 CA392083 H68223 BE892961 AI241335

AI222421 AI634380 CA392084 BE298045 AA504441 AW515068 AI096346 NM_005813

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRKD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAACCTG

About this image

PRKD3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRKD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKD3

SOURCE GeneReport for Unigene cluster: Hs.660757

UniProtKB/Swiss-Prot: KPCD3_HUMAN, O94806

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for PRKD3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKD3 Browse OriGene validated miRNA SYBR primer pairs
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKD3 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRKD3¹	protein kinase D3	82.21(n) 89.78(a)		421478 XM_419526.3 XP_419526.2
lizard (Anolis carolinensis)	Reptilia	PRKD3⁶	--	89(a)	1 ↔ 1	1(235280987-235337384)
zebrafish (Danio rerio)	Actinopterygii	prkd3¹	protein kinase D3	74.01(n) 84.34(a)		557337 XM_680391.4 XP_685483.4
fruit fly (Drosophila melanogaster)	Insecta	PKD¹	Protein Kinase D	55.69(n) 59.27(a)		42203 NM_001144602.1 NP_001138074.1
worm (Caenorhabditis elegans)	Secernentea	dkf-2¹	Protein DKF-2	54.81(n) 55.18(a)		180121 NM_074838.4 NP_507239.2
thale cress (Arabidopsis thaliana)	eudicotyledons	PPCK2⁶ PPCK1⁶ (see all 46)	phosphoenolpyruvate carboxylase kinase 1 (see all 46)	31(a) 31(a) (see all 46)	many ↔ many many ↔ many (see all 46)	3(1221546-1222655) 1(2752154-2753703)
rice (Oryza sativa)	Liliopsida	-- -- (see all 40)	CAMK_CAMK_like.14 - CAMK includes calcium/calmodul... calcium-dependent protein kinase isoform AK1, puta... (see all 40)	27(a) 26(a) (see all 40)	many ↔ many many ↔ many (see all 40)	2(24929065-24930599) 2(34462883-34465156)

ENSEMBL Gene Tree for PRKD3 (if available)
TreeFam Gene Tree for PRKD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PRKD3 gene

PRKD2² PRKD1²

18/31 SIMAP similar genes for PRKD3 using alignment to 4 protein entries: KPCD3_HUMAN (see all proteins) (see all similar genes):

PRKD1 PRKD2 PRKCH GRK5 NEK8 BRSK2

MARK4 PRKACA PRKACB DAPK2 OBSCN PHKG2

RPS6KA1 STK36 NUAK1 PHKG1 IKBKB NEK5

PRKD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200405614^1,2	C,F	other	37506908(+)	`GGCTTC/TTTCAT`	2	K E	mis¹		1		EU	835
rs189862864^1,2		--	37477215(+)	`TTAGTA/GGTGGT`	1	--	ds500¹		0	--	--	--	--
rs11679617^1,2	C,F,A,H	--	37477243(+)	`CAAGAC/TAGTTC`	1	--	ds500¹		9		NA WA EA	370
rs118101727^1,2		--	37477304(+)	`AGGAAG/AACGGA`	1	--	ds500¹		1		EA	120
rs73927424^1,2	C	--	37477306(+)	`GAAGAC/TGGAGG`	1	--	ds500¹		3		WA EA	240
rs182490190^1,2		--	37477391(+)	`TTTTTC/TCAAAG`	1	--	ds500¹		0	--	--	--	--
rs150515137^1,2		--	37477424(+)	`AAGATG/TAGTTA`	1	--	ds500¹		0	--	--	--	--
rs186764864^1,2		--	37477453(+)	`CTCTCA/GGATAT`	1	--	ds500¹		0	--	--	--	--
rs139444359^1,2		--	37477570(+)	`TAACAG/TTTGGA`	1	--	ds500¹		0	--	--	--	--
rs79585227^1,2	C,F	--	37477652(+)	`TAGTAG/TAAAAT`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for PRKD3 (37477645 - 37551951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKD3: --
Human Gene Mutation Database (HGMD): PRKD3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRKD3 for disorders           About GeneDecksing

OMIM gene information: 607077    OMIM disorders: --

11 diseases for PRKD3:    About MalaCards

polycystic kidney disease kidney disease osteoporosis influenza

prostate cancer breast cancer prostatitis immunodeficiency

malaria neuronitis alcoholism

1 disease from the University of Copenhagen DISEASES database for PRKD3:

Polycystic kidney disease

Export disorders for PRKD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRKD3 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with PRKD3)

Utopia: connect your pdf to the dynamic
world of online information

PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu. (PubMed id 10231560)^{1, 2, 3, 9} Hayashi A.... Saito T. (1999)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The nuclear import of protein kinase D3 requires its catalytic activity. (PubMed id 16380377)^{1, 9} Rey O....Rozengurt E. (2006)
Regulation of protein kinase Cnu by the B-cell antigen receptor. (PubMed id 12506120)^{1, 9} Matthews S.A....Scharenberg A.M. (2003)
Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists. (PubMed id 12676944)^{1, 9} Rey O....Rozengurt E. (2003)
Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes. (PubMed id 15496505)^{1, 9} Chen J....Wang Q.J. (2005)
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. (PubMed id 14743217)^{1, 9} Yeaman C....Malhotra V. (2004)
GIT1 phosphorylation on serine 46 by PKD3 regulates pa xillin trafficking and cellular protrusive activity. (PubMed id 22893698)¹ Huck B....Olayioye M.A. (2012)
Protein kinase D-HDAC5 signaling regulates erythropoie sis and contributes to erythropoietin cross-talk with GATA1. (PubMed id 22983445)¹ Delehanty L.L....Goldfarb A.N. (2012)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23683	HGNC: 9408	AceView: PRKCN	Ensembl:ENSG00000115825	euGenes: HUgn23683
ECgene: PRKD3	H-InvDB: PRKD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRKD3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRKD3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRKD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PRKD3 gene:
Search GeneIP for patents involving PRKD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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