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PRKD2 Gene

protein-coding   GIFtS: 68
GCID: GC19M047177

Protein Kinase D2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase D21 2
PKD22 3 5
nPKC-D22 3
EC 2.7.11.133 8
Serine/Threonine-Protein Kinase D22
EC 2.7.118

External Ids:    HGNC: 172931   Entrez Gene: 258652   Ensembl: ENSG000001052877   OMIM: 6070745   UniProtKB: Q9BZL63   

Export aliases for PRKD2 gene to outside databases

Previous GC identifers: GC19M047568 GC19M051853 GC19M051869 GC19M043602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKD2 Gene:
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases.
This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR)
in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate
basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKD2 Gene:
PRKD2 (protein kinase D2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKD3.

UniProtKB/Swiss-Prot: KPCD2_HUMAN, Q9BZL6
Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged
physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3
(ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional
repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in
Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis
induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling,
which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression.
In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2
without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation
of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus,
phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of
NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the
nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is
required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR
engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with
lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated
interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts
with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription
factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to
the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the
basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to
angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor
receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A
(CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in
angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor
growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A
(VEGFA) secretion

summary for PRKD2 Gene:
The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and
PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol
(DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel
signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs
contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a
role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an
autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of
homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are
localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity
of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli
including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress,
cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces
CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the
plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and
transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the
plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in
fundamental physiological processes including signal transduction, membrane trafficking, and cell survival,
migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and
suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the
trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in
regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also
have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only
a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine
cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKD2 gene promoter:
         AREB6   Spz1   Roaz   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKD2 promoter sequence
   Search Chromatin IP Primers for PRKD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

PRKD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047177:  view genomic region     (about GC identifiers)

Start:
47,177,532 bp from pter      End:
47,220,384 bp from pter
Size:
42,853 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KPCD2_HUMAN, Q9BZL6 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase D2  
Size: 878 amino acids; 96750 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts (via C-terminus) with LCK. Interacts (via N-terminal AP-rich region) with CIB1 isoform 2
Sequence caution: Sequence=AAF36107.1; Type=Frameshift; Positions=604, 606, 738, 744, 755, 758, 833, 854;
2 PDB 3D structures from and Proteopedia for PRKD2:
2COA (3D)        3BGM (3D)    
Secondary accessions: Q8TB08 Q9P0T6 Q9Y3X8

Explore the universe of human proteins at neXtProt for PRKD2: NX_Q9BZL6

Explore proteomics data for PRKD2 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-876 correlates with the activation status of the kinase. Ser-706 is probably phosphorylated
    by PKC. Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting.
    Phosphorylation at Ser-244, Ser-706 and Ser-710 is required for nuclear localization. Phosphorylated at Tyr-438
    by ABL1 in response to oxidative stress1
  • Ubiquitination2 at Lys178, Lys286
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKD2 (Q9BZL6) (see all 30)
     IPNNCSG  VKVPHTF  LSHPWLQ  HSYTRPT 


    See PRKD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001073349.1  NP_001073350.1  NP_001073351.1  NP_057541.2  

    ENSEMBL proteins: 
     ENSP00000469106   ENSP00000472913   ENSP00000291281   ENSP00000472744   ENSP00000470804  
     ENSP00000470442   ENSP00000469064   ENSP00000470363   ENSP00000470919   ENSP00000472987  
     ENSP00000393978  

    PRKD2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase D2
    Protein kinase D (PKD) family

    Selected InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9BZL6

    ProtoNet protein and cluster: Q9BZL6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: KPCD2_HUMAN, Q9BZL6
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCD2_HUMAN, Q9BZL6
    Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged
    physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3
    (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional
    repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in
    Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis
    induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling,
    which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression.
    In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2
    without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation
    of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus,
    phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of
    NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the
    nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is
    required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR
    engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with
    lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated
    interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts
    with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription
    factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to
    the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the
    basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to
    angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor
    receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A
    (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in
    angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor
    growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A
    (VEGFA) secretion
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating
    translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves
    auto-inhibition by the PH domain

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA17077180
    GO:0004674protein serine/threonine kinase activity NAS11062248
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17962809
         
    Find genes that share ontologies with PRKD2           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for PRKD2:
     Decreased nuclei size in G2M  Decreased substrate adherent c  Decreased telomerase activity  Decreased viability 
     Gemcitabine induced cell-death  Increased apoptosis  PARP inhibitor sensitization 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prkd2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with PRKD2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKD2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKD2

    miRNA
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    miRTarBase miRNAs that target PRKD2:
    hsa-mir-197-3p (MIRT004187)

    Block miRNA regulation of human, mouse, rat PRKD2 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidPRKD2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 4): PRKD2 (NM_016457)
    Sino Biological Human cDNA Clone for PRKD2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKD2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCD2_HUMAN, Q9BZL6: Cytoplasm. Cell membrane (By similarity). Nucleus. Golgi apparatus, trans-Golgi network.
    Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the
    nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation
    is regulated by blocking nuclear export of active PRKD2 rather than by increasing import
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    golgi apparatus3
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17077180
    GO:0005737cytoplasm IDA17077180
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with PRKD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKD2 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    Development VEGF signaling via VEGFR2 generic cascades0.75
    2G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    3Immune response Function of MEF2 in T lymphocytes
    Immune response Function of MEF2 in T lymphocytes0.38
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5Immune response Fc epsilon RI pathway
    VEGF - VEGF R2 Signaling Pathways0.35


    Find genes that share SuperPaths with PRKD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PRKD2
        VEGF - VEGF R2 Signaling Pathways


    2 Cell Signaling Technology (CST) Pathways for PRKD2
        Ca, cAMP and Lipid Signaling
    PI3K / Akt Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PRKD2 (see all 7)
        Signal transduction Erk Interactions- Inhibition of Erk
    Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction cAMP signaling
    Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation



    1 Kegg Pathway  (Kegg details for PRKD2):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRKD2
    Interactions:

        GeneGlobe Interaction Network for PRKD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PRKD2 (Q9BZL61, 2, 3 ENSP000002912814) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC7Q8WUI41, 2, 3, ENSP000000800594EBI-1384325,EBI-1048378 MINT-6177460 MINT-6177495 MINT-6177477 MINT-6177512 MINT-6177440 MINT-6177417 I2D: score=3 STRING: ENSP00000080059
    GORASP1Q9BQQ32, 3, ENSP000003138694MINT-61760 I2D: score=2 STRING: ENSP00000313869
    CSNK1A1P487292, 3, ENSP000002617984MINT-6177358 I2D: score=1 STRING: ENSP00000261798
    YWHAHQ049172, 3, ENSP000002489754MINT-6177337 I2D: score=1 STRING: ENSP00000248975
    CASKO149362, 3MINT-61755 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation IMP19001381
    GO:0006468protein phosphorylation NAS11062248
    GO:0007155cell adhesion IEA--
    GO:0008219cell death IMP17077180

    Find genes that share ontologies with PRKD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    4 ApexBio Compounds for PRKD2     About this table
    CompoundAction CAS #
    CID 2011756novel and potent inhibitor of PKD1[638156-11-3]
    CID 755673Selective PKD inhibitor[521937-07-5]
    CRT 0066101Potent inhibitor of PKD--
    kb NB 142-70selective PKD inhibitor[1233533-04-4]

    Compounds for PRKD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    kb NB 142-70Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)[1233533-04-4]
    CID 2011756Pan protein kinase D (PKD) inhibitor; cell permeable[638156-11-3]
    CID 755673Selective protein kinase D inhibitor[521937-07-5]

    Selected HMDB Compounds for PRKD2 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    2 Novoseek inferred chemical compound relationships for PRKD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 63.1 16 15975900 (1), 17077180 (1), 12676944 (1), 19001381 (1) (see all 9)
    serine 57.7 16 15975900 (1), 17077180 (1), 12676944 (1), 19001381 (1) (see all 9)



    Find genes that share compounds with PRKD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKD2 gene (4 alternative transcripts): 
    NM_001079880.1  NM_001079881.1  NM_001079882.1  NM_016457.4  

    Unigene Cluster for PRKD2:

    Protein kinase D2
    Hs.466987  [show with all ESTs]
    Unigene Representative Sequence: NM_016457
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601806 ENST00000597390 ENST00000291281(uc002pfj.3) ENST00000602155
    ENST00000600194 ENST00000599019 ENST00000597589 ENST00000595515 ENST00000593492
    ENST00000599464 ENST00000601605 ENST00000597641 ENST00000595132 ENST00000598633
    ENST00000597088 ENST00000593363 ENST00000433867(uc010eks.3 uc010ekt.3 uc002pfg.3 uc002pfh.3 uc002pfi.3 uc010xye.2 uc002pfk.3)

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    Additional mRNA sequence: 

    AF151021.1 AF309082.1 AK074673.1 AK075266.1 AK092896.1 AK095884.1 AK300339.1 AK303629.1 
    AL050147.1 BC015472.1 BC025307.1 

    18 DOTS entries:

    DT.448177  DT.100788789  DT.100835245  DT.97793314  DT.100771701  DT.100788788  DT.121432361  DT.91766382 
    DT.100831049  DT.100726844  DT.95087818  DT.100762622  DT.91766375  DT.97795180  DT.99996218  DT.40107784 
    DT.91766378  DT.95221724 

    Selected AceView cDNA sequences (see all 227):

    AF309082 CD672453 BQ709723 BQ644610 BQ941131 CR598235 CB163081 CD515272 
    CA487156 BM852508 AK074673 BM547262 BG681804 BU150888 BI060735 BC015472 
    BQ711916 BU539011 AL524555 CA487277 BU902379 AK095884 BQ884124 BQ924039 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGATCT
    PRKD2 Expression
    About this image


    PRKD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Pharynx
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Thymus (Hematopoietic System)
     
     Brain (Nervous System)
     
     Spleen (Hematopoietic System)
    PRKD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466987

    UniProtKB/Swiss-Prot: KPCD2_HUMAN, Q9BZL6
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKD2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkd21 , 5 protein kinase D21, 5 88.56(n)1
    95.65(a)1
      7 (9.15 cM)5
    1015401  NM_001252458.11  NP_001239387.11 
     168429025 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    87(a)
    74(a)
    many → 1
    many → 1
    GL343566.1(445263-458870)
    GL343566.1(417177-444056)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.152042 Transcribed sequence with moderate similarity to protein more 79.72(n)    AL887693.2 
    zebrafish
    (Danio rerio)
    Actinopterygii PRKD2 (2 of 5)6
    PRKD2 (4 of 5)6
    (see all 5)
    protein kinase D2
    (see all 5)
    86(a)
    74(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    15(12201343-12236852) ENSDARG00000086199
    Zv9_NA75(8831-13653) ENSDARG00000090158
    fruit fly
    (Drosophila melanogaster)
    Insecta PKD6
    Protein Kinase D
    52(a)
    1 ↔ 1
    3R(14129001-14140129)
    worm
    (Caenorhabditis elegans)
    Secernentea F48G7.106
    Protein F48G7.10 (F48G7.10) mRNA, complete cds
    31(a)
    many ↔ many
    V(633995-634893) WBGene00018621


    ENSEMBL Gene Tree for PRKD2 (if available)
    TreeFam Gene Tree for PRKD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKD2 gene
    PRKD32  PRKD12  
    Selected SIMAP similar genes for PRKD2 using alignment to 10 protein entries:     KPCD2_HUMAN (see all proteins) (see all similar genes):
    PRKD1    PRKCA    CHN2    PRKD3    UNC13B    MARK3
    PRKCG    CAMK2A    CHEK2    STK36    CAMK1G    NUAK1
    PKN2    PNCK    CAMK1D    CAMK1    DKFZp564L2416    NEK6

    Find genes that share paralogs with PRKD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKD2 (see all 909)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423344
    A lung adenocarcinoma sample4--see VAR_0423342 G E mis40--------
    VAR_0423354
    A gastric adenocarcinoma sample4--see VAR_0423352 G E mis40--------
    rs1134291031,2
    C,F--47178894(+) ATGGGG/ATTTCA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs735635091,2
    C,F--47180181(+) GGCATG/AGTGCT 1 -- int13Minor allele frequency- A:0.05WA EA 240
    rs116692091,2
    C,A,H--47212239(+) tttttG/Tttttt 1 -- ds5001 trp30--------
    rs4430811,2
    C,F--47212343(-) GGTAGG/AAGAAT 1 -- ds50012Minor allele frequency- A:0.50NA WA 4
    rs1164342411,2
    F--47362842(+) ACCACG/ATTGGC 4 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1483234161,2
    --47363038(+) CCCTCC/TAGTCA 4 -- ds50010--------
    rs1158775081,2
    C,F--47363104(+) CCTTCT/CCATCT 4 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1844439511,2
    --47363371(+) CACCCC/TACTCC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKD2 (47177532 - 47220384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRKD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833850CNV Loss17160897
    dgv3961n71CNV Loss21882294
    nsv912189CNV Loss21882294
    nsv833849CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607074    OMIM disorders: --


    Find genes that share disorders with PRKD2           About GenesLikeMe

    Genetic Association Database (GAD): PRKD2
    Human Genome Epidemiology (HuGE) Navigator: PRKD2 (8 documents)

    Export disorders for PRKD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKD2 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with PRKD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase d family of serine threonine kinases. (PubMed id 11062248)1, 2, 3, 9 Sturany S....Seufferlein T. (J. Biol. Chem. 2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. (PubMed id 17962809)1, 2, 9 von Blume J.... Seufferlein T. (EMBO J. 2007)
    4. PKD2 interacts with Lck and regulates NFAT activity in T cells. (PubMed id 19192391)1, 2, 9 Li Q.... Luo Y. (BMB Rep. 2009)
    5. Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor. (PubMed id 12058027)1, 2, 9 Sturany S....Seufferlein T. (J. Biol. Chem. 2002)
    6. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. (PubMed id 19001381)1, 2, 9 Hao Q.... Tang H. (J. Biol. Chem. 2009)
    7. Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. (PubMed id 18262756)1, 2, 9 von Wichert G.... Seufferlein T. (Cell. Signal. 2008)
    8. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. (PubMed id 17077180)1, 2, 9 Irie A.... Nishimura Y. (Int. Immunol. 2006)
    9. Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. (PubMed id 15604256)1, 2, 9 Mihailovic T....Seufferlein T. (Cancer Res. 2004)
    10. Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation. (PubMed id 17951978)1, 2, 9 Ge X.... Fu J. (J. Pharmacol. Sci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25865 HGNC: 17293 AceView: PRKD2 Ensembl:ENSG00000105287 euGenes: HUgn25865
    ECgene: PRKD2 Kegg: 25865 H-InvDB: PRKD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKD2 gene:
    Search GeneIP for patents involving PRKD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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