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Aliases for PRKD2 Gene

Aliases for PRKD2 Gene

  • Protein Kinase D2 2 3
  • PKD2 3 4 6
  • EC 2.7.11.13 4 63
  • NPKC-D2 3 4
  • Serine/Threonine-Protein Kinase D2 3
  • EC 2.7.11 63
  • HSPC187 3

External Ids for PRKD2 Gene

Previous GeneCards Identifiers for PRKD2 Gene

  • GC19M047568
  • GC19M051853
  • GC19M051869
  • GC19M047177
  • GC19M043602

Summaries for PRKD2 Gene

Entrez Gene Summary for PRKD2 Gene

  • The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKD2 Gene

PRKD2 (Protein Kinase D2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot for PRKD2 Gene

  • Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Tocris Summary for PRKD2 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol (DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress, cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in fundamental physiological processes including signal transduction, membrane trafficking, and cell survival, migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD2 Gene

Genomics for PRKD2 Gene

Regulatory Elements for PRKD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKD2 Gene

Start:
46,674,275 bp from pter
End:
46,717,127 bp from pter
Size:
42,853 bases
Orientation:
Minus strand

Genomic View for PRKD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD2 Gene

Proteins for PRKD2 Gene

  • Protein details for PRKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL6-KPCD2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D2
    Protein Accession:
    Q9BZL6
    Secondary Accessions:
    • M0R2R2
    • Q8NCK8
    • Q8TB08
    • Q9P0T6
    • Q9Y3X8

    Protein attributes for PRKD2 Gene

    Size:
    878 amino acids
    Molecular mass:
    96750 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts (via C-terminus) with LCK. Interacts (via N-terminal AP-rich region) with CIB1 isoform 2.
    SequenceCaution:
    • Sequence=AAF36107.1; Type=Frameshift; Positions=604, 606, 738, 744, 755, 758, 833, 854; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKD2 Gene

    Alternative splice isoforms for PRKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD2 Gene

Proteomics data for PRKD2 Gene at MOPED

Post-translational modifications for PRKD2 Gene

  • Phosphorylation of Ser-876 correlates with the activation status of the kinase. Ser-706 is probably phosphorylated by PKC. Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting. Phosphorylation at Ser-244, Ser-706 and Ser-710 is required for nuclear localization. Phosphorylated at Tyr-438 by ABL1 in response to oxidative stress.
  • Ubiquitination at Lys178 and Lys286
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKD2 (PKD2)

Domains for PRKD2 Gene

Gene Families for PRKD2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for PRKD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZL6

UniProtKB/Swiss-Prot:

KPCD2_HUMAN :
  • Q9BZL6
Domain:
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKD2: view

Function for PRKD2 Gene

Molecular function for PRKD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Enzyme Numbers (IUBMB) for PRKD2 Gene

Gene Ontology (GO) - Molecular Function for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17077180
GO:0004674 protein serine/threonine kinase activity NAS 11062248
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17962809
genes like me logo Genes that share ontologies with PRKD2: view
genes like me logo Genes that share phenotypes with PRKD2: view

Animal Model Products

CRISPR Products

miRNA for PRKD2 Gene

miRTarBase miRNAs that target PRKD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKD2 Gene

Localization for PRKD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD2 Gene

Cytoplasm. Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKD2 Gene COMPARTMENTS Subcellular localization image for PRKD2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17077180
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRKD2: view

Pathways for PRKD2 Gene

genes like me logo Genes that share pathways with PRKD2: view

Gene Ontology (GO) - Biological Process for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IMP 19001381
GO:0006468 protein phosphorylation NAS 11062248
GO:0007155 cell adhesion IEA --
GO:0008219 cell death IMP 17077180
genes like me logo Genes that share ontologies with PRKD2: view

Compounds for PRKD2 Gene

(4) Tocris Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable [638156-11-3]
CID 755673 Selective protein kinase D inhibitor [521937-07-5]
CRT 0066101 Potent protein kinase D (PKD) inhibitor
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) [1233533-04-4]

(4) ApexBio Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 novel and potent inhibitor of PKD1 [638156-11-3]
CID 755673 Selective PKD inhibitor [521937-07-5]
CRT 0066101 Potent inhibitor of PKD
kb NB 142-70 selective PKD inhibitor [1233533-04-4]

(846) HMDB Compounds for PRKD2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(2) Novoseek inferred chemical compound relationships for PRKD2 Gene

Compound -log(P) Hits PubMed IDs
threonine 63.1 9
serine 57.7 9
genes like me logo Genes that share compounds with PRKD2: view

Transcripts for PRKD2 Gene

Unigene Clusters for PRKD2 Gene

Protein kinase D2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRKD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD2 Gene

No ASD Table

Relevant External Links for PRKD2 Gene

GeneLoc Exon Structure for
PRKD2
ECgene alternative splicing isoforms for
PRKD2

Expression for PRKD2 Gene

mRNA expression in normal human tissues for PRKD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKD2 Gene

This gene is overexpressed in Whole Blood (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRKD2 Gene

SOURCE GeneReport for Unigene cluster for PRKD2 Gene Hs.466987

mRNA Expression by UniProt/SwissProt for PRKD2 Gene

Q9BZL6-KPCD2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with PRKD2: view

In Situ Assay Products

Orthologs for PRKD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD2 35
  • 96.48 (n)
  • 95.82 (a)
PRKD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-2897 36
  • 95 (a)
OneToOne
PRKD2 35
  • 90.43 (n)
  • 95.7 (a)
dog
(Canis familiaris)
Mammalia PRKD2 35
  • 91.15 (n)
  • 96.13 (a)
PRKD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkd2 35
  • 88.56 (n)
  • 95.65 (a)
Prkd2 16
Prkd2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKD2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkd2 35
  • 88.33 (n)
  • 95.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15204 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9355 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01058041.1 36
  • 43 (a)
OneToMany
PRKD2 (1 of 5) 36
  • 61 (a)
OneToMany
PRKD2 (2 of 5) 36
  • 86 (a)
OneToMany
PRKD2 (3 of 5) 36
  • 67 (a)
OneToMany
PRKD2 (4 of 5) 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PKD 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F48G7.10 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3354 36
  • 29 (a)
ManyToMany
Species with no ortholog for PRKD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKD2 Gene

ENSEMBL:
Gene Tree for PRKD2 (if available)
TreeFam:
Gene Tree for PRKD2 (if available)

Paralogs for PRKD2 Gene

Paralogs for PRKD2 Gene

genes like me logo Genes that share paralogs with PRKD2: view

Variants for PRKD2 Gene

Sequence variations from dbSNP and Humsavar for PRKD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs221318 -- 46,700,146(+) cagga(A/G)aatcg intron-variant
rs221319 -- 46,700,275(+) tccca(A/G)atact intron-variant
rs313837 -- 46,717,670(-) GGAGA(C/G)AGACC upstream-variant-2KB
rs313838 -- 46,717,872(-) TCACC(C/T)AAAGT upstream-variant-2KB
rs313839 -- 46,718,300(+) ACCCA(C/G)CCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRKD2 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294
nsv912189 CNV Loss 21882294
nsv833850 CNV Loss 17160897

Relevant External Links for PRKD2 Gene

HapMap Linkage Disequilibrium report
PRKD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD2 Gene

Disorders for PRKD2 Gene

Relevant External Links for PRKD2

Genetic Association Database (GAD)
PRKD2
Human Genome Epidemiology (HuGE) Navigator
PRKD2
genes like me logo Genes that share disorders with PRKD2: view

No data available for UniProtKB/Swiss-Prot for PRKD2 Gene

Publications for PRKD2 Gene

  1. Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase d family of serine threonine kinases. (PMID: 11062248) Sturany S. … Seufferlein T. (J. Biol. Chem. 2001) 2 3 4 23
  2. Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor. (PMID: 12058027) Sturany S. … Seufferlein T. (J. Biol. Chem. 2002) 3 4 23
  3. Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. (PMID: 15604256) Mihailovic T. … Seufferlein T. (Cancer Res. 2004) 3 4 23
  4. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. (PMID: 14743217) Yeaman C. … Malhotra V. (Nat. Cell Biol. 2004) 3 4 23
  5. Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. (PMID: 16928771) Chiu T.T. … Rozengurt E. (Am. J. Physiol. 2007) 3 4 23

Products for PRKD2 Gene

  • Addgene plasmids for PRKD2

Sources for PRKD2 Gene

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