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PRKD1 Gene

protein-coding   GIFtS: 69
GCID: GC14M030045

Protein Kinase D1

(Previous names: protein kinase C, mu)
(Previous symbol: PRKCM)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase D11 2     nPKC-mu2 3
PRKCM1 2 3 5     EC 2.7.11.133 8
PKD2 3 5     PKC-MU2
Protein Kinase C, Mu1 2     PKCM2
Protein Kinase C Mu Type2 3     Serine/Threonine-Protein Kinase D12
Protein Kinase D2 3     PKD13
nPKC-D12 3     EC 2.7.118

External Ids:    HGNC: 94071   Entrez Gene: 55872   Ensembl: ENSG000001843047   OMIM: 6054355   UniProtKB: Q151393   

Export aliases for PRKD1 gene to outside databases

Previous GC identifers: GC14M029115 GC14M010161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKD1 Gene:
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor
signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and
regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 (PubMed 19329994)).(supplied by
OMIM, Nov 2010)

GeneCards Summary for PRKD1 Gene:
PRKD1 (protein kinase D1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and identical protein binding. An important paralog of this gene is PRKD2.

UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139
Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged
physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi
membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell
differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a
role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated
inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues,
which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN
phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and
increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts
downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the
Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network
(TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by
activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of
phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA
(LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface.
Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating
IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by
regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In
osteoblast differentiation, mediates the bone morphogenic protein 2 (BMP2)-induced nuclear export of HDAC7, which
results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in
neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the
maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis
induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2)
signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle
progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes,
through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in
cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5,
MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and
pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which
results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5
pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell
migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which
induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by
cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its
kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial
cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating
TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in
inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly
modulating TRPV1 receptor

summary for PRKD1 Gene:
The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and
PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol
(DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel
signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs
contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a
role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an
autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of
homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are
localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity
of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli
including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress,
cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces
CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the
plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and
transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the
plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in
fundamental physiological processes including signal transduction, membrane trafficking, and cell survival,
migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and
suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the
trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in
regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also
have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only
a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine
cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD1 (Protein kinase D1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKD1 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKD1 promoter sequence
   Search Chromatin IP Primers for PRKD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11

PRKD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKD1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M030045:  view genomic region     (about GC identifiers)

Start:
30,045,685 bp from pter      End:
30,661,104 bp from pter
Size:
615,420 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase D1  
Size: 912 amino acids; 101704 Da
Cofactor: Magnesium
Subunit: Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with MAPK13 and SRC. Interacts with DAPK1 in an
oxidative stress-regulated manner
Secondary accessions: A6NL64 B2RAF6

Explore the universe of human proteins at neXtProt for PRKD1: NX_Q15139

Explore proteomics data for PRKD1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-397 and Ser-401 by MAPK13 during regulation of insulin secretion in pancreatic beta cells.
    Phosphorylated by DAPK1. Phosphorylated by ABL at Tyr-463, which primes the kinase in response to oxidative
    stress, and promotes a second step activating phosphorylation at Ser-738/Ser-742 by PKRD1
  • Ubiquitination2 at Lys292
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKD1 (Q15139) (see all 31)
     LHHPGVV  IPNNCSG  VKVPHTF  VAIKIID 


    See PRKD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002733.2  
    ENSEMBL proteins: 
     ENSP00000333568   ENSP00000390535   ENSP00000447723   ENSP00000447333   ENSP00000446866  
    Reactome Protein details: Q15139

    PRKD1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKD1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKD1
    OriGene Purified Protein for PRKD1
    OriGene Protein Over-expression Lysate for PRKD1
    OriGene MassSpec for PRKD1
    OriGene Custom Protein Services for PRKD1
    GenScript Custom Purified and Recombinant Proteins Services for PRKD1
    Novus Biologicals PRKD1 Proteins
    Novus Biologicals PRKD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKD1 

     
    antibodies-online proteins for PRKD1 (3 products) 

     
    antibodies-online peptides for PRKD1

    PRKD1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKD1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PRKD1  (PKD1)
    OriGene Antibodies for PRKD1
    OriGene Custom Antibody Services for PRKD1
    Novus Biologicals PRKD1 Antibodies
    Abcam antibodies for PRKD1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKD1
    antibodies-online antibodies for PRKD1 (130 products) 

    PRKD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKD1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKD1 
    antibodies-online kits for PRKD1 (25 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase D1
    Protein kinase D (PKD) family
    Protein kinase C

    Selected InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q15139

    ProtoNet protein and cluster: Q15139

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCD1_HUMAN, Q15139
    Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged
    physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi
    membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell
    differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a
    role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated
    inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues,
    which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN
    phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and
    increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts
    downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the
    Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network
    (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by
    activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of
    phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA
    (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface.
    Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating
    IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by
    regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In
    osteoblast differentiation, mediates the bone morphogenic protein 2 (BMP2)-induced nuclear export of HDAC7, which
    results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in
    neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the
    maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis
    induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2)
    signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle
    progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes,
    through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in
    cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5,
    MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and
    pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which
    results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5
    pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell
    migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which
    induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by
    cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its
    kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial
    cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating
    TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in
    inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly
    modulating TRPV1 receptor
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds DAG with high
    affinity and appears to play the dominant role in mediating translocation to the cell membrane and trans-Golgi
    network. Phorbol-ester/DAG-type domain 2 binds phorbol ester with higher affinity. Autophosphorylation of Ser-742
    and phosphorylation of Ser-738 by PKC relieves auto-inhibition by the PH domain. Phosphorylation on Tyr-463 by
    the SRC-ABL1 pathway in response to oxidative stress, is also required for activation. Activated by DAPK1 under
    oxidative stress

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS8119958
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10831594
         
    Find genes that share ontologies with PRKD1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKD1:
     Decreased focal adhesion (FA)   Increased mitotic index 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkd1):
     cardiovascular system  mortality/aging  muscle 

    Find genes that share phenotypes with PRKD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prkd1tm1.1Eno for PRKD1

       genOway: Develop your customized and physiologically relevant rodent model for PRKD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKD1:
    hsa-let-7b-5p (MIRT052152)

    Block miRNA regulation of human, mouse, rat PRKD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKD1 (see all 46):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-376b hsa-miR-128 hsa-miR-449a hsa-miR-105 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPRKD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKD1
    Predesigned siRNA for gene silencing in human, mouse, rat PRKD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKD1

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKD1 (see all 8)
    OriGene ORF clones in mouse, rat for PRKD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKD1 (NM_002742)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKD1
    Addgene plasmids for PRKD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCD1_HUMAN, Q15139: Cytoplasm. Cell membrane. Golgi apparatus, trans-Golgi network (By similarity).
    Note=Translocation to the cell membrane is required for kinase activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    golgi apparatus3
    endoplasmic reticulum2
    extracellular2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA19211839
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PRKD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKD1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    2Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    Development VEGF signaling via VEGFR2 generic cascades0.75
    3Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    5Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43


    Find genes that share SuperPaths with PRKD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PRKD1
        Wnt Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKD1 (see all 74)
        UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    NF-kappaB Activation by Viruses

    1 Cell Signaling Technology (CST) Pathway for PRKD1
        Ca, cAMP and Lipid Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PRKD1 (see all 9)
        Signal transduction Erk Interactions- Inhibition of Erk
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction cAMP signaling
    Transcription Transcription factor Tubby signaling pathways

    Selected BioSystems Pathways for PRKD1 (see all 10)
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    G Protein Signaling Pathways

    1 Reactome Pathway for PRKD1
        Sphingolipid de novo biosynthesis

    1 PharmGKB Pathway for PRKD1
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for PRKD1):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRKD1
    Interactions:

        GeneGlobe Interaction Network for PRKD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKD1 (Q151391, 3 ENSP000003335684) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBPQ070211, 3, ENSP000002256984EBI-1181072,EBI-347528 I2D: score=3 STRING: ENSP00000225698
    MT2AP027951, 3, ENSP000002451854EBI-1181072,EBI-996616 I2D: score=3 STRING: ENSP00000245185
    MAPK13O152641, 3EBI-1181072,EBI-2116951 I2D: score=1 
    CDH1P128301, 3, ENSP000002617694EBI-1181072,EBI-727477 I2D: score=1 STRING: ENSP00000261769
    BTKQ061873, ENSP000003081764I2D: score=3 STRING: ENSP00000308176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001938positive regulation of endothelial cell proliferation IGI--
    GO:0006468protein phosphorylation ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006915apoptotic process IEA--

    Find genes that share ontologies with PRKD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Enzo Life Sciences drugs & compounds for PRKD1
    4 ApexBio Compounds for PRKD1     About this table
    CompoundAction CAS #
    CID 2011756novel and potent inhibitor of PKD1[638156-11-3]
    CID 755673Selective PKD inhibitor[521937-07-5]
    CRT 0066101Potent inhibitor of PKD--
    kb NB 142-70selective PKD inhibitor[1233533-04-4]

    Compounds for PRKD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    kb NB 142-70Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)[1233533-04-4]
    CID 2011756Pan protein kinase D (PKD) inhibitor; cell permeable[638156-11-3]
    CID 755673Selective protein kinase D inhibitor[521937-07-5]

    Selected HMDB Compounds for PRKD1 (see all 847)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-118202152
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----

    Selected Novoseek inferred chemical compound relationships for PRKD1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 86.5 24 8538623 (2), 8078925 (2), 7851400 (2), 20179209 (2) (see all 14)
    syntide-2 85.2 6 8538623 (2), 10748111 (1), 8078925 (1), 11008129 (1)
    threonine 74.8 56 10998417 (1), 15190080 (1), 15975900 (1), 16006559 (1) (see all 39)
    go 6983 74.3 3 14573624 (1), 15755722 (1)
    serine 71.2 76 8538623 (3), 10748111 (2), 8078925 (2), 10998417 (1) (see all 51)
    go 6976 71.2 10 15755722 (3), 14573624 (1), 19896467 (1), 19920860 (1)
    phorbol 12,13-dibutyrate 69.3 21 9973202 (3), 10636921 (2), 14645664 (2), 10998417 (1) (see all 6)
    phorbol 67 12 10498194 (2), 11008129 (2), 10600772 (1), 16313517 (1) (see all 7)
    rottlerin 65.7 5 18227124 (1), 12431976 (1), 15499041 (1)
    gf 109203x 63.8 2 19289471 (1), 18436431 (1)



    Find genes that share compounds with PRKD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKD1 gene: 
    NM_002742.2  

    Unigene Cluster for PRKD1:

    Protein kinase D1
    Hs.508999  [show with all ESTs]
    Unigene Representative Sequence: X75756
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331968(uc001wqh.3) ENST00000415220 ENST00000490795 ENST00000546371
    ENST00000551644 ENST00000468370 ENST00000547441 ENST00000549503
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate PRKD1 (see all 46):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-376b hsa-miR-128 hsa-miR-449a hsa-miR-105 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPRKD1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat PRKD1

    Additional mRNA sequence: 

    AK314170.1 BC029966.1 X75756.1 

    7 DOTS entries:

    DT.112749  DT.91750649  DT.102826234  DT.120768136  DT.75187819  DT.99972123  DT.102826237 

    1 AceView cDNA sequence:

    AW293339 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAGTTTT
    PRKD1 Expression
    About this image


    PRKD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Mesoderm-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PRKD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508999
        Custom PCR Arrays for PRKD1
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKD1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkd11 , 5 protein kinase D11, 5 87.99(n)1
    93.52(a)1
      12 (21.78 cM)5
    187601  NM_008858.31  NP_032884.21 
     503412315 
    chicken
    (Gallus gallus)
    Aves PRKD11 protein kinase D1 81.25(n)
    90.39(a)
      423302  NM_001031201.1  NP_001026372.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKD16
    protein kinase D1
    82(a)
    1 ↔ 1
    1(26601806-26737243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92342 Xenopus laevis transcribed sequence with moderate similarity more 79.88(n)    BU913251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkd11 protein kinase D1 73.71(n)
    83.22(a)
      557123  XM_005158816.1  XP_005158873.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dkf-26
    Protein DKF-2, isoform b (dkf-2) mRNA, complete cd...
    39(a)
    many ↔ many
    V(16747559-16788415) WBGene00012019


    ENSEMBL Gene Tree for PRKD1 (if available)
    TreeFam Gene Tree for PRKD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKD1 gene
    PRKD22  PRKD32  
    Selected SIMAP similar genes for PRKD1 using alignment to 6 protein entries:     KPCD1_HUMAN (see all proteins) (see all similar genes):
    PRKD3    PRKD2    PRKCB    PRKCA    PRKCQ    PRKCG
    PRKCH    BRSK2    CHN2    RASGRP4    RASGRP3    DKFZp686F01113
    PRKCE    PRKY    CHN1    PRKCD    STK17A    TTN

    Find genes that share paralogs with PRKD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKD1 (see all 7031)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354694
    A colorectal cancer sample4--see VAR_0354692 E K mis40--------
    VAR_0423274
    A lung bronchoalveolar carcinoma sample4--see VAR_0423272 R M mis40--------
    VAR_0423264
    A metastatic melanoma sample4--see VAR_0423262 P S mis40--------
    VAR_0354684
    A colorectal cancer sample4--see VAR_0354682 H Y mis40--------
    rs353542491,2
    C--10281205(+) AGTAA-/TAGAGTC 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs339664351,2
    C--10508218(+) AAAAA-/AA/A  
     AA
    /AAAA
    CACAC
    1 -- int11NA 2
    rs726604581,2
    --11398779(+) GTTTTA/CTAGAT 1 -- us2k10--------
    rs1408095811,2
    C--11398783(+) TATAGA/CTATCA 1 -- us2k10--------
    rs454542941,2
    C--30045225(-) TACAGC/TCTGGA 1 -- ds50015Minor allele frequency- T:0.01NS 184
    rs170914571,2
    C,F,H--30045248(+) AGATGC/ACTTTC 1 -- ds500130Minor allele frequency- A:0.06NA NS EA WA 2886

    HapMap Linkage Disequilibrium report for PRKD1 (30045685 - 30295685 bp, first 250kb of PRKD1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKD1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748537CNV Deletion23290073
    dgv289e201CNV Deletion23290073
    esv1587594CNV Deletion17803354
    esv1921382CNV Deletion18987734
    esv2748535CNV Deletion23290073
    esv2740903CNV Deletion23290073
    esv2748536CNV Deletion23290073
    nsv901579CNV Loss21882294
    nsv832761CNV Loss17160897
    nsv518206CNV Loss19592680

    Human Gene Mutation Database (HGMD): PRKD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKD1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605435    OMIM disorders: --


    Find genes that share disorders with PRKD1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKD1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arpkd 40.4 1 14872199 (1)
    cardiac hypertrophy 37.1 1 19683055 (1)
    adpkd 36.9 1 15001556 (1)
    prostate cancer 33 23 12859948 (5), 17979146 (2), 19767773 (2), 15695390 (1) (see all 9)
    pancreatic carcinoma 17.7 1 20082306 (1)
    pancreatic cancer 7.07 7 20442301 (4), 20208318 (1)
    tumors 1.54 6 16083495 (1), 14604983 (1), 11978539 (1), 15755722 (1) (see all 5)
    necrosis 0 2 14604983 (1), 15755722 (1)
    adenocarcinoma 0 3 11912133 (1), 20082306 (1)
    carcinoma 0 2 9935238 (1), 7851400 (1)

    Genetic Association Database (GAD): PRKD1
    Human Genome Epidemiology (HuGE) Navigator: PRKD1 (2 documents)

    Export disorders for PRKD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKD1 gene, integrated from 10 sources (see all 307):
    (articles sorted by number of sources associating them with PRKD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PKCmu is a novel, atypical member of the protein kinase C family. (PubMed id 8119958)1, 2, 3, 9 Johannes F.-J.... Pfizenmaier K. (J. Biol. Chem. 1994)
    2. Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. (PubMed id 17442957)1, 2, 9 Ivison S.M.... Steiner T.S. (J. Immunol. 2007)
    3. Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. (PubMed id 12637538)1, 2, 9 Storz P.... Toker A. (J. Biol. Chem. 2003)
    4. Protein kinase D: an intracellular traffic regulator on the move. (PubMed id 11978539)1, 2, 9 Van Lint J.... Seufferlein T. (Trends Cell Biol. 2002)
    5. Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor. (PubMed id 10523301)1, 2, 9 Bagowski C.P.... Ullrich A. (EMBO J. 1999)
    6. A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation. (PubMed id 17804414)1, 2, 9 Doppler H. and Storz P. (J. Biol. Chem. 2007)
    7. Protein kinase d in the cardiovascular system: emerging roles in health and disease. (PubMed id 18239146)1, 2, 9 Avkiran M.... Haworth R.S. (Circ. Res. 2008)
    8. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. (PubMed id 12505989)1, 2, 9 Storz P. and Toker A. (EMBO J. 2003)
    9. Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis. (PubMed id 19655095)1, 2, 9 Ha C.H. and Jin Z.G. (Mol. Cells 2009)
    10. Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor- induced gene expression and angiogenesis. (PubMed id 18332134)1, 2, 9 Ha C.H.... Jin Z.G. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5587 HGNC: 9407 AceView: PRKCM.1 Ensembl:ENSG00000184304 euGenes: HUgn5587
    ECgene: PRKD1 Kegg: 5587 H-InvDB: PRKD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKD1 gene:
    Search GeneIP for patents involving PRKD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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