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Aliases for PRKD1 Gene

Aliases for PRKD1 Gene

  • Protein Kinase D1 2 3 5
  • Protein Kinase C Mu Type 3 4
  • Protein Kinase C, Mu 2 3
  • Protein Kinase D 3 4
  • EC 2.7.11.13 4 61
  • NPKC-D1 3 4
  • NPKC-Mu 3 4
  • PRKCM 3 4
  • PKD 3 4
  • Serine/Threonine-Protein Kinase D1 3
  • EC 2.7.11 61
  • PKC-MU 3
  • CHDED 3
  • PKCM 3
  • PKD1 4

External Ids for PRKD1 Gene

Previous HGNC Symbols for PRKD1 Gene

  • PRKCM

Previous GeneCards Identifiers for PRKD1 Gene

  • GC14M029115
  • GC14M030045
  • GC14M010161

Summaries for PRKD1 Gene

Entrez Gene Summary for PRKD1 Gene

  • The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]

GeneCards Summary for PRKD1 Gene

PRKD1 (Protein Kinase D1) is a Protein Coding gene. Diseases associated with PRKD1 include Malignant Epithelial Tumor Of Salivary Glands and Subacute Glomerulonephritis. Among its related pathways are CCR5 Pathway in Macrophages and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is PRKD3.

UniProtKB/Swiss-Prot for PRKD1 Gene

  • Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity).

Tocris Summary for PRKD1 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.

Gene Wiki entry for PRKD1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD1 Gene

Genomics for PRKD1 Gene

Regulatory Elements for PRKD1 Gene

Enhancers for PRKD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G029857 0.8 ENCODE dbSUPER 10.5 +334.1 334100 1.1 NR2F1 IKZF1 ASH2L JUNB ETV6 IKZF2 SPI1 PRKD1 RNU6-1234P LOC105370429
GH14G029886 0.9 dbSUPER 9 +305.6 305551 0.6 HDAC1 PKNOX1 FOXA2 ARID4B BMI1 RARA SLC30A9 EGR1 RELB CREM PRKD1 LOC105370429 RNU6-1234P
GH14G030228 0.7 Ensembl ENCODE 11.5 -36.3 -36315 1.0 FOS DNMT3B PRKD1 ENSG00000248975
GH14G029893 0.7 dbSUPER 10.9 +297.6 297603 0.8 L3MBTL2 NFRKB NRF1 ELF4 ZFHX2 POLR2A ZSCAN29 PRDM10 TAF7 PRDM4 PRKD1 LOC105370429 RNU6-1234P
GH14G029892 0.6 dbSUPER 8.8 +299.4 299449 0.7 ZNF639 ZNF362 FEZF1 ZEB2 ATF2 PRDM6 ZNF692 MYNN ZNF629 PRKD1 LOC105370429 RNU6-1234P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKD1 Gene

Chromosome:
14
Start:
29,576,479 bp from pter
End:
30,191,898 bp from pter
Size:
615,420 bases
Orientation:
Minus strand

Genomic View for PRKD1 Gene

Genes around PRKD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD1 Gene

Proteins for PRKD1 Gene

  • Protein details for PRKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15139-KPCD1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D1
    Protein Accession:
    Q15139
    Secondary Accessions:
    • A6NL64
    • B2RAF6

    Protein attributes for PRKD1 Gene

    Size:
    912 amino acids
    Molecular mass:
    101704 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts (via N-terminus) with ADAP1/CENTA1 (PubMed:12893243). Interacts with MAPK13 (PubMed:19135240). Interacts with DAPK1 in an oxidative stress-regulated manner (PubMed:17703233). Interacts with USP28; the interaction induces phosphorylation of USP28 and activated KRAS-mediated stabilization of ZNF304 (PubMed:24623306). Interacts with AKAP13 (via C-terminal domain) (By similarity).

neXtProt entry for PRKD1 Gene

Selected DME Specific Peptides for PRKD1 Gene

Q15139:
  • AIDLINNLLQVKMRKRYSVDK
  • LHHPGVV
  • LHFKNIVHCDLKPENVLLASA
  • GCGLNYHKRCAF
  • QIQENVDI
  • VFVVMEKLHGDMLEMILSSEKGRLPE
  • HSYTRPT
  • GLVRQGL
  • YLAPEVL
  • YDKILLF
  • VNLECMFETPE
  • IPNNCSG
  • VKVPHTF
  • KEGWMVHYTS
  • TISPSTSNNIPLMRVVQS
  • VAIKIID
  • RQGLQCK
  • LLKGLFRQG
  • EDFQIRPH
  • GERYITHESDD
  • GYNRSLDMWSVGVI
  • QKFPECGF
  • YYKEIPLSEIL
  • TQILVALR
  • VYGGKHRKTGRDVA
  • YVSLSGTFPFNEDEDI
  • LSHPWLQ
  • DMWSVGVI
  • DQIQNAAFMYP
  • RFPTKQESQLRNEVAILQNLHHPG
  • KCITLFQN

Post-translational modifications for PRKD1 Gene

  • Phosphorylated at Ser-397 and Ser-401 by MAPK13 during regulation of insulin secretion in pancreatic beta cells (PubMed:19135240). Phosphorylated by DAPK1 (PubMed:17703233). Phosphorylated at Tyr-95 and by ABL at Tyr-463, which primes the kinase in response to oxidative stress, and promotes a second step activating phosphorylation at Ser-738/Ser-742 by PKRD (PubMed:12637538, PubMed:15024053, PubMed:17804414). Phosphorylated on Ser-910 upon S.enterica infection in macrophages (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRKD1 Gene

Suggested Antigen Peptide Sequences for PRKD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15139

UniProtKB/Swiss-Prot:

KPCD1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
genes like me logo Genes that share domains with PRKD1: view

Function for PRKD1 Gene

Molecular function for PRKD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds DAG with high affinity and appears to play the dominant role in mediating translocation to the cell membrane and trans-Golgi network. Phorbol-ester/DAG-type domain 2 binds phorbol ester with higher affinity. Autophosphorylation of Ser-742 and phosphorylation of Ser-738 by PKC relieves auto-inhibition by the PH domain. Phosphorylation on Tyr-463 by the SRC-ABL1 pathway in response to oxidative stress, is also required for activation. Activated by DAPK1 under oxidative stress.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the intestine-specific transcription factor CDX1 in a activated KRAS-dependent manner in colorectal cancer (CRC) cells (PubMed:24623306).

Enzyme Numbers (IUBMB) for PRKD1 Gene

Gene Ontology (GO) - Molecular Function for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IDA 8119958
GO:0004697 protein kinase C activity IDA 12637538
GO:0005515 protein binding IPI 10831594
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKD1: view
genes like me logo Genes that share phenotypes with PRKD1: view

Animal Models for PRKD1 Gene

MGI Knock Outs for PRKD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRKD1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKD1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKD1 Gene

Localization for PRKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD1 Gene

Cytoplasm. Cell membrane. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKD1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IDA 22095288
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA 11239398
genes like me logo Genes that share ontologies with PRKD1: view

Pathways & Interactions for PRKD1 Gene

genes like me logo Genes that share pathways with PRKD1: view

SIGNOR curated interactions for PRKD1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IGI 20497126
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IDA 24623306
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PRKD1: view

Drugs & Compounds for PRKD1 Gene

(30) Drugs for PRKD1 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Aldosterone Experimental Pharma Agonist 0
CID 2011756 Pharma PKD inhibitor, Pan protein kinase D (PKD) inhibitor; cell permeable 0
CID 755673 Pharma PKD inhibitor, Selective protein kinase D inhibitor 0
CRT 0066101 Pharma PKD inhibitor, Potent protein kinase D (PKD) inhibitor 0

(19) Additional Compounds for PRKD1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(4) Tocris Compounds for PRKD1 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable 638156-11-3
CID 755673 Selective protein kinase D inhibitor 521937-07-5
CRT 0066101 Potent protein kinase D (PKD) inhibitor 1883545-60-5
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) 1233533-04-4

(4) ApexBio Compounds for PRKD1 Gene

Compound Action Cas Number
CID 2011756 PKD inhibitor 638156-11-3
CID 755673 PKD inhibitor 521937-07-5
CRT 0066101 PKD inhibitor
kb NB 142-70 Inhibitor of protein kinase D,selective 1233533-04-4
genes like me logo Genes that share compounds with PRKD1: view

Drug Products

Transcripts for PRKD1 Gene

Unigene Clusters for PRKD1 Gene

Protein kinase D1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKD1

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD1 Gene

No ASD Table

Relevant External Links for PRKD1 Gene

GeneLoc Exon Structure for
PRKD1
ECgene alternative splicing isoforms for
PRKD1

Expression for PRKD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKD1 Gene

Protein differential expression in normal tissues from HIPED for PRKD1 Gene

This gene is overexpressed in Cerebrospinal fluid (19.3), Testis (18.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKD1 Gene



Protein tissue co-expression partners for PRKD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKD1 Gene:

PRKD1

SOURCE GeneReport for Unigene cluster for PRKD1 Gene:

Hs.508999

Evidence on tissue expression from TISSUES for PRKD1 Gene

  • Kidney(3)
  • Heart(2.5)
  • Muscle(2.5)
  • Nervous system(2.2)
  • Blood(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PRKD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKD1 Gene

Orthologs for PRKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia PRKD1 34 35
  • 93.24 (n)
cow
(Bos Taurus)
Mammalia PRKD1 34 35
  • 92.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD1 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkd1 34 16 35
  • 87.99 (n)
rat
(Rattus norvegicus)
Mammalia Prkd1 34
  • 87.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKD1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKD1 34 35
  • 81.25 (n)
lizard
(Anolis carolinensis)
Reptilia PRKD1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkd1 34
  • 74.22 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9234 34
zebrafish
(Danio rerio)
Actinopterygii PRKD1 35
  • 82 (a)
OneToOne
prkd1 34
  • 73.71 (n)
worm
(Caenorhabditis elegans)
Secernentea dkf-2 35
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for PRKD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKD1 Gene

ENSEMBL:
Gene Tree for PRKD1 (if available)
TreeFam:
Gene Tree for PRKD1 (if available)

Paralogs for PRKD1 Gene

Variants for PRKD1 Gene

Sequence variations from dbSNP and Humsavar for PRKD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035468 A colorectal cancer sample
VAR_035469 A colorectal cancer sample
VAR_042326 A metastatic melanoma sample
VAR_042327 A lung bronchoalveolar carcinoma sample
rs193921103 Uncertain significance 29,599,730(-) ATGGA(A/G)ACATG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRKD1 Gene

Variant ID Type Subtype PubMed ID
dgv262e201 CNV deletion 23290073
dgv620e212 CNV loss 25503493
esv1587594 CNV deletion 17803354
esv1921382 CNV deletion 18987734
esv2740903 CNV deletion 23290073
esv2748535 CNV deletion 23290073
esv2748536 CNV deletion 23290073
esv2748537 CNV deletion 23290073
esv3581096 CNV loss 25503493
esv3581097 CNV loss 25503493
esv3633934 CNV loss 21293372
esv3633935 CNV gain 21293372
esv3633936 CNV loss 21293372
esv3633937 CNV gain 21293372
esv3633938 CNV loss 21293372
nsv1071139 CNV deletion 25765185
nsv1118280 CNV deletion 24896259
nsv1122883 CNV deletion 24896259
nsv1139897 CNV deletion 24896259
nsv1145818 CNV deletion 26484159
nsv1153221 CNV deletion 26484159
nsv456195 CNV loss 19166990
nsv477400 CNV novel sequence insertion 20440878
nsv518206 CNV loss 19592680
nsv518869 CNV loss 19592680
nsv526536 CNV gain 19592680
nsv564160 CNV gain 21841781
nsv564162 CNV loss 21841781
nsv832761 CNV loss 17160897
nsv958732 CNV deletion 24416366

Variation tolerance for PRKD1 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKD1 Gene

Human Gene Mutation Database (HGMD)
PRKD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD1 Gene

Disorders for PRKD1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for PRKD1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant epithelial tumor of salivary glands
subacute glomerulonephritis
autosomal dominant polycystic kidney disease
  • polycystic kidney and hepatic disease 1
polycystic kidney disease, adult type i
  • polycystic kidney disease 1
polycystic kidney and hepatic disease
  • polycystic kidney disease, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search PRKD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKD1

Genetic Association Database (GAD)
PRKD1
Human Genome Epidemiology (HuGE) Navigator
PRKD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKD1
genes like me logo Genes that share disorders with PRKD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKD1 Gene

Publications for PRKD1 Gene

  1. PKCmu is a novel, atypical member of the protein kinase C family. (PMID: 8119958) Johannes F.-J. … Pfizenmaier K. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis. (PMID: 19655095) Ha C.H. … Jin Z.G. (Mol. Cells 2009) 3 4 22