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PRKD1 Gene

protein-coding GIFtS: 59

GC14M029115

protein kinase D1
(Previous names: protein kinase C, mu )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PRKCM)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.13 ^³
PKC-MU ^²
PKC-mu ^¹
PKCM ^¹, ²
PKD ^¹, ², ³
PKD1 ^³
PRKCM ^², ³
nPKC-D1 ^³
nPKC-mu ^³

Descriptions
Protein kinase C mu type ^³
Protein kinase D ^³
protein kinase C, mu ^¹, ²
protein kinase D1 ^²

External Ids
HGNC: 9407¹
Entrez Gene: 5587²
UniProtKB: Q15139³
Ensembl: ENSG00000184304⁷

Search outside databases for aliases for PRKD1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PRKD1:

Members of the protein kinase C (PKC) family function in many extracellular receptor-mediated

signal transduction pathways. See PRKCA (MIM 176960) for further background information. The PRKCM

gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and

regulates the fission of transport carriers specifically destined to the cell surface.[supplied by

OMIM]

UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139

Function: Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase

involved in resistance to oxidative stress

Gene Wiki entry for PRKD1 (Protein_kinase_D1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PRKD1 gene

Entrez Gene cytogenetic band: 14q11 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11

PRKD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M029115: (about GC identifiers)

Start:	29,115,436 bp from pter
End:	29,466,699 bp from pter
Size:	351,264 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase D1

Size: 912 amino acids; 101704 Da

Subunit: Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with Src

Secondary accessions: A6NL64 B2RAF6

Post-translational modifications:

Phosphorylation of Ser-738 and/or Ser-742 in activated PKD is mediated by transphosphorylation (By

similarity). Phosphorylation of Tyr-463 mediated by the Src/Abl pathway in response to oxidative

stress activates the kinase¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002733.2

ENSEMBL proteins:

ENSP00000333568 ENSP00000374634 ENSP00000374635 ENSP00000379907

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PRKD1
	Millipore Purified and/or Recombinant PRKD1 Protein
	Sigma-Aldrich Proteins for PRKD1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PRKD1
	Recombinant Proteins from Abcam (PKC mu)
	Human Recombinant Proteins from Abnova (PRKD1)

OriGene Purified Recombinant Human Protein: PRKD1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	10856238
GO:0005886	plasma membrane	TAS	8119958 10856238
GO:0005887	integral to plasma membrane	TAS	8119958

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Antibodies for PRKD1:

	Invitrogen Antibodies for PRKD1
	Millipore Mono- and Polyclonal Antibodies for the study of PRKD1
	Sigma-Aldrich Antibody Arrays and Antibodies for PRKD1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PRKD1 (PKD1, PKCmu)
	Antibodies from Abcam (PKC mu), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PRKD1)
	Novus Biologicals Antibodies for PRKD1

Assays for PRKD1:

	Invitrogen Assays for PRKD1
	Millipore Kits and Assays for the Analysis of PRKD1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15139

ProtoNet protein and cluster: Q15139

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD

subfamily

Similarity: Contains 1 PH domain

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRKD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRKD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002742

Applied Biosystems Silencer® siRNAs for PRKD1

Sigma-Aldrich siRNA and siRNA Panels for PRKD1

Sigma-Aldrich shRNA Panels and shRNA for PRKD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002742
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002742
untagged cDNA clones in CMV expression vector (see all 2): NM_002742

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002742

UniProtKB/Swiss-Prot: KPCD1_HUMAN, Q15139

Function: Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase

involved in resistance to oxidative stress

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by diacylglycerol and phorbol esters

Enzyme Number (IUBMB): EC 2.7.11.13

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prkd1):

lethality-prenatal/perinatal

muscle

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004697	protein kinase C activity	IEA	--
GO:0005515	protein binding	IPI	12893243
GO:0005524	ATP binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/49 Sigma-Aldrich "Your Favorite Gene" Pathways for PRKD1 (Your Favorite Gene powered by Ingenuity) (see all 49 )

Factors Promoting Cardiogenesis in Vertebrates
Glioma Signaling
Synaptic Long Term Depression
Renin-Angiotensin Signaling
fMLP Signaling in Neutrophils

GeneDecks PRKD1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PRKD1

5/62 Interacting proteins for PRKD1 (ENSP00000333568³ Q15139¹) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDH1	P12830¹	STRING (score=.96) EBI-1181072, EBI-727477
MAPK13	O15264¹	EBI-1181072, EBI-2116951
MT2A	P02795¹	EBI-1181072, EBI-996616
HDAC5	ENSP00000225983³	STRING (score=.995)
KIDINS220	ENSP00000256707³	STRING (score=.972)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	8119958
GO:0007242	intracellular signaling cascade	IEA	--
GO:0008283	cell proliferation	TAS	8119958

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PRKD1

Browse Small Molecules at Sigma-Aldrich

Compounds for PRKD1 available from Tocris Bioscience

Compound	Action	CAS number
CID 755673	Selective protein kinase D inhibitor	[521937-07-5]

About this table

10/21 Novoseek chemical compound relationships for PRKD1 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pkcs	86.62	19	8538623 (2), 8078925 (2), 7851400 (2), 14645664 (2) (see all 12)
syntide-2	86.01	6	8538623 (2), 10748111 (1), 8078925 (1), 11008129 (1)
go 6983	76.01	3	14573624 (1), 15755722 (1)
threonine	75.05	55	10998417 (1), 15190080 (1), 15975900 (1), 16006559 (1) (see all 38)
phorbol 12,13-dibutyrate	69.02	21	9973202 (3), 10636921 (2), 14645664 (2), 10998417 (1) (see all 6)
phorbol	68.41	12	10498194 (2), 11008129 (2), 10600772 (1), 16313517 (1) (see all 7)
bryostatin 1	48.64	6	18765827 (2), 10622742 (1), 9765302 (1)
bisindolylmaleimide	33.53	2	9990296 (1)
ceramide	31.63	4	17591919 (2), 9799101 (1)
tyrosine	27.50	14	12637538 (4), 17804414 (2), 10748111 (1), 15378608 (1) (see all 9)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRKD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRKD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002742

Sigma-Aldrich siRNA and siRNA Panels for PRKD1

Sigma-Aldrich shRNA Panels and shRNA for PRKD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002742

REFSEQ mRNAs for PRKD1 gene:

NM_002742.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002742

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002742
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002742
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002742

Additional cDNA sequence:

AK314170.1 BC029966.1 X75756.1

7 DOTS entries:

DT.112749 DT.91750649 DT.102826234 DT.75187819 DT.120768136 DT.99972123 DT.102826237

1 AceView cDNA sequence:

AW293339

highest scoring ESTs for PRKD1:

X75756 AI141181 AI198975 BI825769 AA095689 AA150207 AA152269 AA234607 AA236577 AA599429

Unigene Cluster for PRKD1:

Protein kinase D1

Hs.508999 [show with all ESTs]

Unigene Representative Sequence: X75756

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000331968 ENST00000389984 ENST00000389985 ENST00000396674

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PRKD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PRKD1

¹ / ² / ³

3 probe-sets matching PRKD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
123_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X75756	1.00	1.00	1.00	1
205880_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002742	0.60	1.00	0.82	1
205880_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACAAGTTTT

SOURCE GeneReport for Unigene cluster: Hs.508999
Expression variation in blood from EXPOLDB for PRKD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PRKD1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PRKD1¹	--	protein kinase D1	93.4(n) 96.74(a)	609091 XM_846293.1 XP_851386.1
chimpanzee (Pan troglodytes)	PRKD1¹	--	protein kinase D1	99.49(n) 99.45(a)	452834 XM_001170806.1 XP_001170806.1
cow (Bos taurus)	PRKD1¹	--	protein kinase D1	92.68(n) 96.6(a)	533270 XM_612625.3 XP_612625.3
rat (Rattus norvegicus)	Prkd1¹	--	protein kinase D1	87.77(n) 93.96(a)	85421 XM_234108.4 XP_234108.4
mouse (Mus musculus)	Prkd1^{1, 5}	12⁵	protein kinase D1^{1, 5}	87.95(n)¹ 93.41(a)¹	18760¹ NM_008858.2¹ NP_032884.1¹ Z34524⁵

About this table Species with no ortholog for PRKD1

ENSEMBL Gene Tree for PRKD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PRKD1 gene

PRKD2² PRKD3² CHEK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2216 NCBI SNPs in PRKD1 are shown (see all 2216 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 531)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11984^1,2	A,C,F,H,O	29115729(-)	`TGAATG/AAGGAG`	1	--	ut3¹		11	MN EU EA WA NS	968
	rs2004414^1,2	C,F,H,O	29115352(-)	`GCTCAA/GAAAGC`	1	--	ng5¹		13	EA WA NA NS	782
	rs17091457^1,2	C,F,H	29114999(+)	`AGATGC/ACTTTC`	1	--	ng5¹		20	NA EU EA WA NS	1576
	rs2151745^1,2	C,F,H	29468278(-)	`AATGCA/GGTTGT`	1	--	ng3¹		13	EU EA WA NS	970
	rs10498313^1,2	C,F,H	29468627(+)	`TTGAGA/GTTCAA`	1	--	ng3¹		13	NS EU EA WA NA	726
	rs11161065^1,2	C,H	29117278(+)	`GCTTTC/TTCATT`	1	R/K	mis¹		4	EU EA WA	418
--	rs45512592^1,2	F	29115333(-)	`AGCTCA/GTAGTG`	1	--	ng5¹		5	NS	184
--	rs12892121^1,2	H	29165446(+)	`CTCCAT/AAAACA`	1	F/Y	mis¹ ese³		4	EU EA WA	406
--	rs45508998^1,2	F	29467632(-)	`AGGAAA/CATAGT`	1	--	ng3¹		5	NS	188
--	rs45477998^1,2	F	29467300(-)	`TCCCTT/CGACCC`	1	--	ng3¹		5	NS	188

About this table

HapMap Linkage Disequilibrium images for PRKD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605435

10/11 Novoseek disease relationships for PRKD1 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arpkd	42.98	1	14872199 (1)
adpkd	39.60	1	15001556 (1)
prostate cancer	28.62	19	12859948 (5), 17979146 (2), 15695390 (1), 19141652 (1) (see all 6)
necrosis	0.00	2	14604983 (1), 15755722 (1)
psoriasis	0.00	1	16536798 (1)
cancer	0.00	7	11008129 (2), 12646240 (2), 18765827 (1)
carcinoma	0.00	2	9935238 (1), 7851400 (1)
cysts	0.00	2	14872199 (1), 11245774 (1)
tumors	0.00	5	16083495 (1), 14604983 (1), 11978539 (1), 15755722 (1)
adenocarcinoma	0.00	2	11912133 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/218 PubMed articles for PRKD1 gene (see all 218 ):

PKCmu is a novel, atypical member of the protein kinase C family. (PubMed id 8119958)^{1, 2, 3, 4} Johannes F.-J.... Pfizenmaier K. (1994)
Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. (PubMed id 12637538)^{1, 3, 4} Storz P.... Toker A. (2003)
A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation. (PubMed id 17804414)^{1, 3, 4} Doppler H. and Storz P. (2007)
Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. (PubMed id 12893243)^{3, 4} Zemlickova E.... Aitken A. (2003)
Assignment of protein kinase C mu (PRKCM) to human chromosome band 14q11 with somatic cell hybrids and radiation hybrids. (PubMed id 10965134)^{2, 3} Owczarek C.M....Hertzog P.J. (2000)
Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. (PubMed id 15755722)^{1, 3} Zhang W....Min W. (2005)
PKD: a new protein kinase C-dependent pathway in platelets. (PubMed id 12393506)^{1, 3} Stafford M.J....Pears C.J. (2003)
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus. (PubMed id 11948398)^{1, 3} Hurd C....Rozengurt E. (2002)
Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. (PubMed id 17442957)^{1, 3} Ivison S.M....Steiner T.S. (2007)
The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase. (PubMed id 15123666)^{1, 3} Li J....Evers B.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5587	HGNC: 9407	AceView: PRKCM.1	Ensembl:ENSG00000184304	euGenes: HUgn5587
ECgene: PRKD1	H-InvDB: PRKD1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PRKD1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PRKD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PRKD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PRKD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PRKD1		Antibodies for PRKD1
	Explore super-pooled esiRNAs		Proteins for PRKD1
	Lentivirus-delivered shRNAs for PRKD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PRKD1)
	Antibodies (PRKD1)
	Chimera RNAi (PRKD1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PRKD1 (PKD1, PKCmu)

	Recombinant Proteins (PKC mu)
	Antibodies (PKC mu)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PRKD1

	Drugs/Proteins for PRKD1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PRKD1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PRKD1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for PRKD1

Summaries
for PRKD1

Genomic Location
for PRKD1

Proteins
for PRKD1

Protein Domains/
Families
for PRKD1

Gene Function
for PRKD1

Pathways & Interactions
for PRKD1

Drugs & Compounds
for PRKD1

Transcripts
for PRKD1

Expression
for PRKD1

Orthologs
for PRKD1

Paralogs
for PRKD1

SNPs/Variants
for PRKD1

Disorders & Mutations
for PRKD1

Medical News
for PRKD1

Publications
for PRKD1

Search for PRKD1

Genome Databases showing PRKD1

Other Databases showing PRKD1

Specialized Databases showing PRKD1

Licensable Technologies
for PRKD1

Services
for PRKD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PRKD1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor PRKD1

Summariesfor PRKD1

Genomic Locationfor PRKD1

Proteinsfor PRKD1

Protein Domains/Familiesfor PRKD1

Gene Functionfor PRKD1

Pathways & Interactionsfor PRKD1

Drugs & Compoundsfor PRKD1

Transcriptsfor PRKD1

Expression for PRKD1

Orthologsfor PRKD1

Paralogsfor PRKD1

SNPs/Variantsfor PRKD1

Disorders & Mutationsfor PRKD1

Medical Newsfor PRKD1

Publicationsfor PRKD1

Search for PRKD1

Genome Databases showing PRKD1

Other Databases showing PRKD1

Specialized Databases showing PRKD1

Licensable Technologiesfor PRKD1

Servicesfor PRKD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PRKD1

Summaries
for PRKD1

Genomic Location
for PRKD1

Proteins
for PRKD1

Protein Domains/
Families
for PRKD1

Gene Function
for PRKD1

Pathways & Interactions
for PRKD1

Drugs & Compounds
for PRKD1

Transcripts
for PRKD1

Expression
for PRKD1

Orthologs
for PRKD1

Paralogs
for PRKD1

SNPs/Variants
for PRKD1

Disorders & Mutations
for PRKD1

Medical News
for PRKD1

Publications
for PRKD1

Licensable Technologies
for PRKD1

Services
for PRKD1