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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCZ Gene

protein-coding   GIFtS: 71
GCID: GC01P001982

Protein Kinase C, Zeta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase C, Zeta1 2     PKC-ZETA2
PKC22 3 5     Protein Kinase C Zeta Type2
nPKC-zeta2 3     EC 2.7.118
EC 2.7.11.133 8     

External Ids:    HGNC: 94121   Entrez Gene: 55902   Ensembl: ENSG000000676067   OMIM: 1769825   UniProtKB: Q055133   

Export aliases for PRKCZ gene to outside databases

Previous GC identifers: GC01P001538 GC01P001939 GC01P9M0003 GC01P001260


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKCZ Gene:
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a
variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC
isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and
diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot
be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module.
These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from
other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCZ Gene: 
PRKCZ (protein kinase C, zeta) is a protein-coding gene. Diseases associated with PRKCZ include parainfluenza virus type 3, and myofibrillar myopathy, and among its related super-pathways are fMLP Pathway and Translation Insulin regulation of translation. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is ENSG00000258989.

UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved
in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and
maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following
mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade
independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an
adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and
contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose
transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its
kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in
interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in
TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads
to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and
is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and
dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In inflammatory response, is
required for the T-helper 2 (Th2) differentiation process, including interleukins production, efficient
activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in
development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes
by phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal
CA1 pyramidal cells

summary for PRKCZ Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCZ (Protein kinase M zeta/Protein kinase C zeta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCZ gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCZ promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33-p36.2   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33-p36.2

PRKCZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001982:  view genomic region     (about GC identifiers)

Start:
1,981,909 bp from pter      End:
2,116,834 bp from pter
Size:
134,926 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513 (See protein sequence)
Recommended Name: Protein kinase C zeta type  
Size: 592 amino acids; 67660 Da
Subunit: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3.
Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of
a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary
complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts
(via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in
the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3
and TIAM1. Interacts with PDPK1 (via N-terminus region)
Subcellular location: Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the
rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for
its localization to the cell junction
Sequence caution: Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K4N0 A8MU64 B7Z2J7 E9PCW2 Q15207 Q5SYT5 Q969S4
Alternative splicing: 3 isoforms:  Q05513-1   Q05513-2   Q05513-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKCZ: NX_Q05513

Explore proteomics data for PRKCZ at MOPED 

Post-translational modifications:

  • UniProtKB: CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is
    inhibited by the apoptotic C-terminus cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the
    kinase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05513

  • 4/26 DME Specific Peptides for PRKCZ (Q05513) (see all 26)
     LHSCFQT  GHIKLTD  VNGGDLM  LIIHVFP 

    PRKCZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKCZ Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001028753.1  NP_001028754.1  NP_001229803.1  NP_002735.3  

    ENSEMBL proteins: 
     ENSP00000367830   ENSP00000424945   ENSP00000421587   ENSP00000383712   ENSP00000427085  
     ENSP00000426412   ENSP00000462105   ENSP00000424228   ENSP00000421869   ENSP00000425643  
     ENSP00000425317   ENSP00000424763   ENSP00000421219   ENSP00000421350   ENSP00000422349  
     ENSP00000427134   ENSP00000422764   ENSP00000424398   ENSP00000383711  
    Reactome Protein details: Q05513
    Human Recombinant Protein Products for PRKCZ: 
    EMD Millipore Purified and/or Recombinant PRKCZ Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCZ
    OriGene Purified Proteins for PRKCZ
    OriGene Protein Over-expression Lysate for PRKCZ
    OriGene MassSpec for PRKCZ 
    OriGene Custom Protein Services for PRKCZ
    GenScript Purified and Recombinant Proteins for PRKCZ
    Novus Biologicals PRKCZ Proteins
    Novus Biologicals PRKCZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm TAS7925449
    GO:0005768endosome IEA--
    GO:0005829cytosol IEA--

    PRKCZ for ontologies           About GeneDecksing



    PRKCZ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCZ
    R&D Systems Antibodies for PRKCZ (PKC zeta)
    Cell Signaling Technology (CST) Antibodies for PRKCZ  (PKCZ)
    OriGene Antibodies for PRKCZ
    OriGene Custom Antibody Services for PRKCZ
    GenScript Superior Antibodies for PRKCZ
    Novus Biologicals PRKCZ Antibodies
    Abcam antibodies for PRKCZ
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PRKCZ
    LSBio Antibodies in human, mouse, rat for PRKCZ 

    Assay Products for PRKCZ: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCZ
    Browse R&D Systems for biochemical assays
    GenScript PRKCZ-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, zeta 
    Iota subfamily
    Protein kinase C

    5/11 InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR012233 PKC_zeta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05513

    ProtoNet protein and cluster: Q05513

    3 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Domain: The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B
    Domain: The C1 domain does not bind the diacylglycerol (DAG)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    PRKCZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCZ_HUMAN, Q05513
    Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
    phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved
    in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and
    maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following
    mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade
    independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an
    adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and
    contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose
    transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its
    kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in
    interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in
    TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads
    to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and
    is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and
    dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In inflammatory response, is
    required for the T-helper 2 (Th2) differentiation process, including interleukins production, efficient
    activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in
    development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
    NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes
    by phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal
    CA1 pyramidal cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due
    to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol
    esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn
    motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a
    physiological activator (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity IDA15069075
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11260256
         
    PRKCZ for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKCZ:
     Increased cell death HMECs cel  Increases Tamoxifen sensitivit 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Prkcz):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     pigmentation  vision/eye 

    PRKCZ for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkcztm1.1Msg for PRKCZ

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKCZ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKCZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCZ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCZ 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCZ
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRKCZ:
    hsa-miR-448
    SwitchGear 3'UTR luciferase reporter plasmidPRKCZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRKCZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCZ
    Sirion Biotech Customized adenovirus for overexpression of PRKCZ

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRKCZ (see all 22)
    OriGene ORF clones in mouse, rat for PRKCZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKCZ (NM_002744)
    Sino Biological Human cDNA Clone for PRKCZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCZ
    Sirion Biotech Customized lentivirus for stable overexpression of PRKCZ 
                         Customized lentivirus expression plasmids for stable overexpression of PRKCZ 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCZ
    Search LifeMap BioReagents cell lines for PRKCZ
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCZ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKCZ About   (see all 97)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Insulin signaling pathway0.31
    Transcription Receptor-mediated HIF regulation0.51
    3Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.75
    VEGF - VEGF R2 Signaling Pathways 0.39
    Development VEGF signaling and activation0.75
    4Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    5Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/19 EMD Millipore Pathways for PRKCZ (see all 19)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Immune response CCR3 signaling in eosinophils
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    3 R&D Systems Pathways for PRKCZ
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCZ (see all 74)
        UVB-Induced MAPK Signaling
    Intracellular Calcium Signaling
    NF-kappaB Activation by Viruses
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCZ
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCZ
        NF-kappaB Pathway
    VEGF Pathway

    5/21 GeneGo (Thomson Reuters) Pathways for PRKCZ (see all 21)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Translation Insulin regulation of translation

    5/31 BioSystems Pathways for PRKCZ (see all 31)
        MAPK signaling pathway
    Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway
    Insulin Signaling

    3 Sino Biological Pathways for PRKCZ 
        EGFR Signaling Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    5/6        Reactome Pathways for PRKCZ (see all 6)
        Hemostasis
    Signaling by TGF-beta Receptor Complex
    Signal Transduction
    Platelet activation, signaling and aggregation
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

    3 PharmGKB Pathways for PRKCZ
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/7         Kegg Pathways  (Kegg details for PRKCZ) (see all 7):
        Chemokine signaling pathway
    Endocytosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Tight junction


    PRKCZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/202 Interacting proteins for PRKCZ (Q055131, 2, 3 ENSP000003678304) via UniProtKB, MINT, STRING, and/or I2D (see all 202)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000270149Q9Y6242, 3, ENSP000002897794MINT-4085708 I2D: score=2 STRING: ENSP00000289779
    F11RQ9Y6242, 3MINT-4085708 I2D: score=2 
    PRKCQQ047591, 3, ENSP000002631254EBI-295351,EBI-374762 I2D: score=2 STRING: ENSP00000263125
    CCDC115Q96NT02, 3MINT-8267287 I2D: score=2 
    HSP90AB1P082381, 3EBI-295351,EBI-352572 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001954positive regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation IDA10770950
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS8224878

    PRKCZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCZ for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCZ:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCZ

    Compounds for PRKCZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    10/846 HMDB Compounds for PRKCZ (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    1 IUPHAR Ligand for PRKCZ (protein kinase C, zeta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    arachidonic acid
    ActivatorActivation7744003

    10/28 Novoseek inferred chemical compound relationships for PRKCZ gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 73.7 2 7639744 (1), 20236250 (1)
    phosphatidylinositol 69.4 21 10887180 (1), 12376338 (1), 17005646 (1), 11278885 (1) (see all 17)
    ly294002 65.1 2 19290459 (1), 12970779 (1)
    ceramide 57 8 10962008 (2), 16456021 (1), 9605434 (1), 19959757 (1) (see all 7)
    phosphoinositide 56.3 2 10528195 (1), 14500673 (1)
    okadaic acid 43 1 10781824 (1)
    phorbol 39.9 1 9169602 (1)
    serine 38.1 1 18202124 (1)
    c2ceramide 36.5 1 11679435 (1)
    rapamycin 34.9 1 18927238 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCZ / KPCZ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKCZ gene (4 alternative transcripts): 
    NM_001033581.1  NM_001033582.1  NM_001242874.1  NM_002744.4  

    Unigene Cluster for PRKCZ:

    Protein kinase C, zeta
    Hs.496255  [show with all ESTs]
    Unigene Representative Sequence: NM_002744
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000378567(uc001aiq.3) ENST00000468310 ENST00000484419 ENST00000503297
    ENST00000479566 ENST00000466651 ENST00000400921(uc001air.3) ENST00000495347
    ENST00000461106(uc010nyw.2) ENST00000461465 ENST00000470596 ENST00000496325
    ENST00000481140 ENST00000482686 ENST00000486681 ENST00000470986 ENST00000470511
    ENST00000471018
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRKCZ:
    hsa-miR-448
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK097627.1 AK131526.1 AK290995.1 AK294649.1 AK294782.1 AK302160.1 AK310372.1 BC008058.2 
    BC014270.2 BC128516.1 BT007082.1 L14283.1 Z15108.1 

    24/41 DOTS entries (see all 41):

    DT.449881  DT.75173685  DT.95267145  DT.100808988  DT.100037896  DT.95267152  DT.92450209  DT.95267155 
    DT.100742693  DT.121417966  DT.100815035  DT.92450220  DT.121417885  DT.75194260  DT.95267147  DT.100639808 
    DT.100685232  DT.92411816  DT.92450205  DT.92450207  DT.95234995  DT.121417805  DT.121417828  DT.75100734 

    24/367 AceView cDNA sequences (see all 367):

    AL538613 BE394483 BC014270 BF992427 CB152283 BM562781 BM666249 BC008058 
    CK821048 BM711266 CB155525 BU543815 BM664518 BU752466 BQ183175 AI188467 
    BP347301 BM696253 BX094098 BM841262 BU734096 BE898490 CB146130 BP348843 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
    SP1:              -                 -                 -     -     -     -     -     -     -     -     -     -     -     -           -                       -   
    SP2:                                                                                                        -     -     -           -                       -   
    SP3:                                                                                                        -     -     -           -                       -   
    SP4:                                                                                                                                -                       -   
    SP5:                                                                          -     -     -     -     -     -     -     -           -                       -   

    ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:  -     -     -     -     -                                                                                         -     -               
    SP2:  -     -     -     -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:  -                                                                                                                                       
    SP5:  -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for PRKCZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCZ expression in normal human tissues (normalized intensities)      PRKCZ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTTTCCAA
    PRKCZ Expression
    About this image


    PRKCZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
             skeleton/axial skeleton   
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
             skeleton/axial skeleton   

    See PRKCZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCZ

    SOURCE GeneReport for Unigene cluster: Hs.496255

    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCZ (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              Type I Interferon Response in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKCZ gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcz1 , 5 protein kinase C, zeta1, 5 88.85(n)1
    95.61(a)1
      4 (86.17 cM)5
    187621  NM_008860.21  NP_032886.21 
     1552601295 
    chicken
    (Gallus gallus)
    Aves PRKCZ1 protein kinase C, zeta 78.43(n)
    89.86(a)
      419399  XM_417561.3  XP_417561.3 
    zebrafish
    (Danio rerio)
    Actinopterygii prkcz1 protein kinase C, zeta 74.04(n)
    81.76(a)
      555737  NM_001030091.1  NP_001025262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aPKC3 oocyte determination protein
    serine/threonine more
    62(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-36
    Protein kinase C-like 3
    56(a)
    1 → many
    II(5380025-5384171)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKC16
    Protein serine/threonine kinase essential for cell...
    13(a)
    1 → many
    II(14241-17696)


    ENSEMBL Gene Tree for PRKCZ (if available)
    TreeFam Gene Tree for PRKCZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCZ gene
    ENSG000002589892  PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  
    PRKCD2  PKN32  PRKCG2  PKN22  
    18/71 SIMAP similar genes for PRKCZ using alignment to 16 protein entries:     KPCZ_HUMAN (see all proteins) (see all similar genes):
    PRKCI    PKN2    PRKCH    DMPK    PRKCB    MARK4
    RPS6KA5    AKT1    PKN1    SGK2    AKT3    PRKCG
    KIN27    RPS6KA3    PRKCE    PRKACB    NUAK1    PRKG1

    PRKCZ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3777 SNPs in PRKCZ are shown (see all 3777)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423114
    A colorectal adenocarcinoma sample4--see VAR_0423112 R C mis40--------
    VAR_0354674
    A colorectal cancer sample4--see VAR_0354672 S F mis40--------
    rs1424259541,2
    --1979927(+) TGGCT-/GGTGCA 1 -- us2k10--------
    rs1806745131,2
    --1979927(+) GTGGCG/TGTGCA 1 -- us2k10--------
    rs1861618921,2
    C--1979957(+) AAGACA/GGAGGC 1 -- us2k10--------
    rs1909291211,2
    C--1979972(+) GCAGCA/CAAGAG 1 -- us2k10--------
    rs1448838531,2
    --1980128(+) TGGTTA/GGGAGC 1 -- us2k10--------
    rs751481171,2
    C,F--1980170(+) GCGGGC/ACAAAG 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1150747691,2
    F--1980185(+) AGGCTG/AGGGCT 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1479572101,2
    --1980190(+) GGGGCG/TCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKCZ (1981909 - 2116834 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/55 variations for PRKCZ (see all 55):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717917CNV Deletion23290073
    esv4759CNV Deletion18987735
    esv4294CNV Deletion18987735
    esv2716140CNV Deletion23290073
    dgv8e201CNV Deletion23290073
    esv2717473CNV Deletion23290073
    esv2715806CNV Deletion23290073
    esv2717806CNV Deletion23290073
    esv2668737CNV Deletion23128226
    dgv1e194CNV Deletion18987734

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176982    OMIM disorders: --

    20/40 diseases for PRKCZ (see all 40):    About MalaCards
    parainfluenza virus type 3    myofibrillar myopathy    nasopharyngitis    soft tissue sarcoma
    kaposi's sarcoma    myopathy    glioblastoma    astrocytoma
    sarcoma    obesity    intrahepatic cholangiocarcinoma    cholera
    alzheimer's disease    pancreatitis    cholangiocarcinoma    insulin resistance
    huntington's disease    psoriasis    endotheliitis    inflammatory bowel disease


    PRKCZ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/15 Novoseek inferred disease relationships for PRKCZ gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 23.7 2 15093250 (1), 11020447 (1)
    parainfluenza 22.7 2 7761474 (2)
    necrosis 21.9 2 11278885 (1), 12887331 (1)
    glioblastoma 11.2 2 19187446 (1), 10982151 (1)
    pancreatic carcinoma 9.83 1 7576113 (1)
    nasopharyngeal carcinoma 5.16 2 11284734 (1), 15670898 (1)
    tumors 5.09 4 11278885 (1), 16778206 (1), 11912160 (1), 8700129 (1)
    niddm 0 1 18615853 (1)
    leukemia 0 1 12105221 (1)
    breast cancer 0 2 19201988 (1), 15735031 (1)

    Genetic Association Database (GAD): PRKCZ
    Human Genome Epidemiology (HuGE) Navigator: PRKCZ (8 documents)

    Export disorders for PRKCZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCZ gene, integrated from 9 sources (see all 435):
    (articles sorted by number of sources associating them with PRKCZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. (PubMed id 18615853)1, 4, 9 Qin L....Zhou J. (2008)
    2. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PubMed id 9768361)1, 2, 9 Chou M.M.... Toker A. (1998)
    3. The cDNA sequence encoding human protein kinase C-zeta. (PubMed id 8224878)1, 2, 9 Barbee J.L.... Burns D.J. (1993)
    4. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. (PubMed id 12887891)1, 2, 9 Wilson M.I.... Williams R.L. (2003)
    5. Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. (PubMed id 11035106)1, 2, 9 Monick M.M....Hunninghake G.W. (2000)
    6. Genome-wide pharmacogenomic study of neurocognition a s an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    9. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    10. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)1, 2 Hilton H.N.... Ormandy C.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5590 HGNC: 9412 AceView: PRKCZ Ensembl:ENSG00000067606 euGenes: HUgn5590
    ECgene: PRKCZ Kegg: 5590 H-InvDB: PRKCZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCZ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKCZ gene:
    Search GeneIP for patents involving PRKCZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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