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Aliases for PRKCZ Gene

Aliases for PRKCZ Gene

  • Protein Kinase C Zeta 2 3 5
  • EC 2.7.11.13 4 58
  • NPKC-Zeta 3 4
  • PKC2 3 4
  • Protein Kinase C Zeta Type 3
  • Protein Kinase C, Zeta 2
  • EC 2.7.11 58
  • PKC-ZETA 3

External Ids for PRKCZ Gene

Previous GeneCards Identifiers for PRKCZ Gene

  • GC01P001538
  • GC01P001939
  • GC01P9M0003
  • GC01P001260
  • GC01P001982

Summaries for PRKCZ Gene

Entrez Gene Summary for PRKCZ Gene

  • Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCZ Gene

PRKCZ (Protein Kinase C Zeta) is a Protein Coding gene. Diseases associated with PRKCZ include Chromosome 1P36 Deletion Syndrome. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AGE/RAGE pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCI.

UniProtKB/Swiss-Prot for PRKCZ Gene

  • Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

Tocris Summary for PRKCZ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCZ Gene

Additional gene information for PRKCZ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCZ Gene

Genomics for PRKCZ Gene

Regulatory Elements for PRKCZ Gene

Enhancers for PRKCZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H002045 1.6 FANTOM5 ENCODE dbSUPER 10.7 -0.4 -406 8 MLX ARID4B DMAP1 YY1 ZNF121 GLIS2 ZNF143 FOS ATF7 SP3 UBE2J2 CDK11B CDK11A INTS11 PRKCZ ENSG00000271806 ANKRD65 FNDC10 SLC35E2B NADK
GH01H001989 1.1 Ensembl ENCODE 11.5 -60.3 -60296 1 BCOR HDAC1 PKNOX1 KLF1 ATF1 ZMYM3 TCF12 ZFHX2 MTA3 CTBP1 GABRD LOC105378589 TMEM52 CALML6 LOC105378591 PRKCZ ENSG00000272512 CFAP74 PIR40513
GH01H002104 0.9 ENCODE 5.3 +54.7 54727 2 FOXA2 MLX ARID4B KLF17 DMAP1 RAD21 THRB RARA THAP11 SMARCC1 FAAP20 ENSG00000271806 PRKCZ ANKRD65 SKI GC01M002102 GC01M002070
GH01H002069 0.7 ENCODE 5.4 +21.3 21328 4 MXI1 ATF1 BCL11B RARA TEAD3 ZFHX2 POLR2A RCOR1 ATF7 CREM GABRD LOC105378589 CFAP74 PRKCZ SCNN1D GC01M002070 GC01P002058
GH01H002265 0.6 dbSUPER 6 +216.5 216530 3 ZIC2 HIC1 ZNF316 GLIS2 ZNF366 HNF4A ZNF600 MAFK PRDM1 SKI MORN1 RER1 PRKCZ PIR45792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCZ on UCSC Golden Path with GeneCards custom track

Promoters for PRKCZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000276 230 1401 INSM2 ARID4B ZNF76 KLF17 DMAP1 THRB RFX5 ZNF121 GLIS2 RCOR1

Genomic Location for PRKCZ Gene

Chromosome:
1
Start:
2,050,470 bp from pter
End:
2,185,395 bp from pter
Size:
134,926 bases
Orientation:
Plus strand

Genomic View for PRKCZ Gene

Genes around PRKCZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCZ Gene

Proteins for PRKCZ Gene

  • Protein details for PRKCZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05513-KPCZ_HUMAN
    Recommended name:
    Protein kinase C zeta type
    Protein Accession:
    Q05513
    Secondary Accessions:
    • A8K4N0
    • A8MU64
    • B7Z2J7
    • E9PCW2
    • Q15207
    • Q5SYT5
    • Q969S4

    Protein attributes for PRKCZ Gene

    Size:
    592 amino acids
    Molecular mass:
    67660 Da
    Quaternary structure:
    • Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with PDPK1 (via N-terminal region). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with WDFY2 and VAMP2 (PubMed:17313651).
    SequenceCaution:
    • Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRKCZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCZ Gene

Selected DME Specific Peptides for PRKCZ Gene

Q05513:
  • DEDIDWVQTEK
  • VNGGDLM
  • HPLTLKWVDSEGDP
  • GIIYRDLK
  • AYCGQCSERIWGL
  • CINCKLLVHK
  • TVSSQMEL
  • FLNKDPKERLGC
  • EGDPCTVSSQ
  • YRRGARRW
  • YAMKVVKKELV
  • FQAKRFNR
  • TSTFCGTPNYIAPEILRG
  • LIIHVFP
  • RVIGRGSYAKVLLVRLKK
  • NTEDYLFQ
  • IDQSEFEGFEYINPLL
  • YRDLKLDN
  • VDWWALGVL
  • GHIKLTD
  • LHSCFQT
  • EPVQLTPDD
  • YIAPEIL
  • YGFSVDWWALGVLMFEMMAGRSPFDI
  • RDLKLDN
  • CGTPNYIAPE

Post-translational modifications for PRKCZ Gene

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCZ (PKCZ)

Domains & Families for PRKCZ Gene

Gene Families for PRKCZ Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCZ Gene

Graphical View of Domain Structure for InterPro Entry

Q05513

UniProtKB/Swiss-Prot:

KPCZ_HUMAN :
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • The C1 domain does not bind the diacylglycerol (DAG).
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCZ: view

Function for PRKCZ Gene

Molecular function for PRKCZ Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity).
UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

Enzyme Numbers (IUBMB) for PRKCZ Gene

Phenotypes From GWAS Catalog for PRKCZ Gene

Gene Ontology (GO) - Molecular Function for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 10770950
GO:0004674 protein serine/threonine kinase activity IEA,IDA 15069075
GO:0004697 protein kinase C activity TAS --
GO:0005515 protein binding IPI 10831594
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKCZ: view
genes like me logo Genes that share phenotypes with PRKCZ: view

Animal Models for PRKCZ Gene

MGI Knock Outs for PRKCZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRKCZ

CRISPR Products

miRNA for PRKCZ Gene

miRTarBase miRNAs that target PRKCZ

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCZ
  • Applied Biological Materials Clones for PRKCZ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCZ Gene

Localization for PRKCZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCZ Gene

Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells. Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Colocalizes with VAMP2 and WDFY2 in intracellular vesicles. {ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCZ gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 4
cytoskeleton 3
nucleus 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm TAS 7925449
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with PRKCZ: view

Pathways & Interactions for PRKCZ Gene

genes like me logo Genes that share pathways with PRKCZ: view

Pathways by source for PRKCZ Gene

SIGNOR curated interactions for PRKCZ Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IDA,IEA 10770950
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 8224878
genes like me logo Genes that share ontologies with PRKCZ: view

Drugs & Compounds for PRKCZ Gene

(37) Drugs for PRKCZ Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 399
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
arachidonic acid Experimental Nutra Activator 32
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 50

(18) Additional Compounds for PRKCZ Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCZ Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8

(12) ApexBio Compounds for PRKCZ Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
ZIP, Biotinylated
genes like me logo Genes that share compounds with PRKCZ: view

Drug Products

Transcripts for PRKCZ Gene

Unigene Clusters for PRKCZ Gene

Protein kinase C, zeta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCZ
  • Applied Biological Materials Clones for PRKCZ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - -
SP18: -
SP19: - - - - - - - - - - - -
SP20: - - - -
SP21: -
SP22:

ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - - -
SP18:
SP19:
SP20: - - - - -
SP21: -
SP22:

Relevant External Links for PRKCZ Gene

GeneLoc Exon Structure for
PRKCZ
ECgene alternative splicing isoforms for
PRKCZ

Expression for PRKCZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCZ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCZ Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8), Brain - Cerebellum (x4.6), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for PRKCZ Gene

This gene is overexpressed in Lung (38.3), Placenta (8.0), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCZ Gene



Protein tissue co-expression partners for PRKCZ Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKCZ Gene:

PRKCZ

SOURCE GeneReport for Unigene cluster for PRKCZ Gene:

Hs.496255

mRNA Expression by UniProt/SwissProt for PRKCZ Gene:

Q05513-KPCZ_HUMAN
Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.

Evidence on tissue expression from TISSUES for PRKCZ Gene

  • Nervous system(5)
  • Liver(4.4)
  • Intestine(4.3)
  • Muscle(2.2)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with PRKCZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCZ Gene

Orthologs for PRKCZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCZ 33
  • 99.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCZ 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 89 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PRKCZ 33 34
  • 89.11 (n)
mouse
(Mus musculus)
Mammalia Prkcz 33 16 34
  • 88.85 (n)
rat
(Rattus norvegicus)
Mammalia Prkcz 33
  • 88.74 (n)
cow
(Bos Taurus)
Mammalia PRKCZ 34 33
  • 88.74 (n)
OneToOne
chicken
(Gallus gallus)
Aves PRKCZ 33 34
  • 78.43 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcz 33
  • 75.13 (n)
zebrafish
(Danio rerio)
Actinopterygii prkcz 33 34
  • 74.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta aPKC 35 34
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 34
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToMany
Species where no ortholog for PRKCZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCZ Gene

ENSEMBL:
Gene Tree for PRKCZ (if available)
TreeFam:
Gene Tree for PRKCZ (if available)

Paralogs for PRKCZ Gene

Paralogs for PRKCZ Gene

genes like me logo Genes that share paralogs with PRKCZ: view

Variants for PRKCZ Gene

Sequence variations from dbSNP and Humsavar for PRKCZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs376894109 A colorectal adenocarcinoma sample 2,175,293(+) TCTTC(C/T)GCAGC nc-transcript-variant, reference, missense
VAR_035467 A colorectal cancer sample
rs1000007735 -- 2,172,917(+) CAGCC(-/GT)GTGTG intron-variant
rs1000019726 -- 2,106,661(+) CTCCA(C/T)GTGTG intron-variant
rs1000021623 -- 2,050,282(+) GCCGC(A/G)GCCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRKCZ Gene

Variant ID Type Subtype PubMed ID
dgv18e59 CNV duplication 20981092
dgv1e194 CNV deletion 18987734
dgv44n54 CNV loss 21841781
dgv45n54 CNV gain 21841781
dgv46n54 CNV gain+loss 21841781
dgv47n54 CNV loss 21841781
dgv48n54 CNV loss 21841781
dgv49n54 CNV loss 21841781
esv1002714 CNV insertion 20482838
esv1008133 CNV gain 20482838
esv1138741 CNV deletion 17803354
esv1162822 CNV insertion 17803354
esv2196740 CNV deletion 18987734
esv2313378 CNV deletion 18987734
esv2492368 CNV insertion 19546169
esv2505453 CNV deletion 19546169
esv2668737 CNV deletion 23128226
esv26913 CNV gain+loss 19812545
esv27078 CNV loss 19812545
esv2758913 CNV gain+loss 17122850
esv3388837 CNV duplication 20981092
esv3585020 CNV loss 21293372
esv3585021 CNV loss 21293372
esv3585022 CNV gain 21293372
esv4294 CNV loss 18987735
esv4759 CNV loss 18987735
esv4841 CNV loss 18987735
nsv1074070 CNV deletion 25765185
nsv1074479 CNV deletion 25765185
nsv1075767 CNV duplication 25765185
nsv1113061 CNV deletion 24896259
nsv1121435 CNV deletion 24896259
nsv1121436 CNV deletion 24896259
nsv1122280 CNV deletion 24896259
nsv1130941 CNV deletion 24896259
nsv1137181 CNV deletion 24896259
nsv1140401 CNV tandem duplication 24896259
nsv1143429 CNV deletion 24896259
nsv1153893 CNV deletion 26484159
nsv160060 CNV insertion 16902084
nsv2520 CNV insertion 18451855
nsv3631 CNV insertion 18451855
nsv460616 CNV loss 19166990
nsv461727 CNV loss 19166990
nsv470681 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509479 CNV insertion 20534489
nsv545045 CNV loss 21841781
nsv545055 CNV gain 21841781
nsv545062 CNV loss 21841781
nsv821592 CNV deletion 20802225
nsv822920 CNV gain 20364138
nsv834446 CNV loss 17160897
nsv834557 CNV loss 17160897
nsv951425 CNV deletion 24416366
nsv951470 CNV deletion 24416366
nsv951471 CNV deletion 24416366
nsv951530 CNV deletion 24416366

Variation tolerance for PRKCZ Gene

Residual Variation Intolerance Score: 8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCZ Gene

Disorders for PRKCZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRKCZ Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1p36 deletion syndrome
  • 1p36 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRKCZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCZ

Genetic Association Database (GAD)
PRKCZ
Human Genome Epidemiology (HuGE) Navigator
PRKCZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCZ
genes like me logo Genes that share disorders with PRKCZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCZ Gene

Publications for PRKCZ Gene

  1. Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. (PMID: 18615853) Qin L … Zhou J (Diabetes/metabolism research and reviews 2008) 3 22 45 60
  2. Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. (PMID: 11035106) Monick MM … Hunninghake GW (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60
  3. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PMID: 9768361) Chou MM … Toker A (Current biology : CB 1998) 3 4 22 60
  4. The cDNA sequence encoding human protein kinase C-zeta. (PMID: 8224878) Barbee JL … Burns DJ (Gene 1993) 3 4 22 60
  5. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 45 60

Products for PRKCZ Gene

  • Addgene plasmids for PRKCZ
  • Santa Cruz Bio