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Aliases for PRKCZ Gene

Aliases for PRKCZ Gene

  • Protein Kinase C, Zeta 2 3
  • PKC2 3 4 6
  • EC 2.7.11.13 4 63
  • NPKC-Zeta 3 4
  • Protein Kinase C Zeta Type 3
  • EC 2.7.11 63
  • PKC-ZETA 3

External Ids for PRKCZ Gene

Previous GeneCards Identifiers for PRKCZ Gene

  • GC01P001538
  • GC01P001939
  • GC01P9M0003
  • GC01P001260
  • GC01P001982

Summaries for PRKCZ Gene

Entrez Gene Summary for PRKCZ Gene

  • Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCZ Gene

PRKCZ (Protein Kinase C, Zeta) is a Protein Coding gene. Diseases associated with PRKCZ include parainfluenza virus type 3. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCZ Gene

  • Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis.

Tocris Summary for PRKCZ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCZ Gene

Genomics for PRKCZ Gene

Regulatory Elements for PRKCZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKCZ Gene

Start:
2,050,470 bp from pter
End:
2,185,395 bp from pter
Size:
134,926 bases
Orientation:
Plus strand

Genomic View for PRKCZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCZ Gene

Proteins for PRKCZ Gene

  • Protein details for PRKCZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05513-KPCZ_HUMAN
    Recommended name:
    Protein kinase C zeta type
    Protein Accession:
    Q05513
    Secondary Accessions:
    • A8K4N0
    • A8MU64
    • B7Z2J7
    • E9PCW2
    • Q15207
    • Q5SYT5
    • Q969S4

    Protein attributes for PRKCZ Gene

    Size:
    592 amino acids
    Molecular mass:
    67660 Da
    Quaternary structure:
    • Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with PDPK1 (via N-terminal region).
    SequenceCaution:
    • Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRKCZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCZ Gene

Proteomics data for PRKCZ Gene at MOPED

Post-translational modifications for PRKCZ Gene

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCZ (PKCZ)

Domains for PRKCZ Gene

Suggested Antigen Peptide Sequences for PRKCZ Gene

Graphical View of Domain Structure for InterPro Entry

Q05513

UniProtKB/Swiss-Prot:

KPCZ_HUMAN :
  • Q05513
Domain:
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PB1 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with PRKCZ: view

Function for PRKCZ Gene

Molecular function for PRKCZ Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity).
UniProtKB/Swiss-Prot Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis.

Enzyme Numbers (IUBMB) for PRKCZ Gene

Gene Ontology (GO) - Molecular Function for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10770950
GO:0004674 protein serine/threonine kinase activity IDA 15069075
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11260256
genes like me logo Genes that share ontologies with PRKCZ: view
genes like me logo Genes that share phenotypes with PRKCZ: view

Animal Models for PRKCZ Gene

MGI Knock Outs for PRKCZ:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PRKCZ Gene

Localization for PRKCZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCZ Gene

Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCZ Gene COMPARTMENTS Subcellular localization image for PRKCZ gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm TAS 7925449
GO:0005768 endosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with PRKCZ: view

Pathways for PRKCZ Gene

SuperPathways for PRKCZ Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 IL-2 Pathway
3 fMLP Pathway
4 Translation Insulin regulation of translation
5 Sweet Taste Signaling
genes like me logo Genes that share pathways with PRKCZ: view

Pathways by source for PRKCZ Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IDA 10770950
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 8224878
genes like me logo Genes that share ontologies with PRKCZ: view

Compounds for PRKCZ Gene

Compound Products

(5) Tocris Compounds for PRKCZ Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(10) ApexBio Compounds for PRKCZ Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(846) HMDB Compounds for PRKCZ Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(1) IUPHAR Ligand for PRKCZ Gene

Ligand Type Action Affinity Pubmed IDs
arachidonic acid Activator Potentiation

(28) Novoseek inferred chemical compound relationships for PRKCZ Gene

Compound -log(P) Hits PubMed IDs
pkcs 73.7 2
phosphatidylinositol 69.4 17
ly294002 65.1 2
ceramide 57 8
phosphoinositide 56.3 2
genes like me logo Genes that share compounds with PRKCZ: view

Transcripts for PRKCZ Gene

Unigene Clusters for PRKCZ Gene

Protein kinase C, zeta:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - -
SP18: -
SP19: - - - - - - - - - - - -
SP20: - - - -
SP21: -
SP22:

ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - - -
SP18:
SP19:
SP20: - - - - -
SP21: -
SP22:

Relevant External Links for PRKCZ Gene

GeneLoc Exon Structure for
PRKCZ
ECgene alternative splicing isoforms for
PRKCZ

Expression for PRKCZ Gene

mRNA expression in normal human tissues for PRKCZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCZ Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.8), Brain - Cerebellum (4.6), and Brain - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCZ Gene

SOURCE GeneReport for Unigene cluster for PRKCZ Gene Hs.496255

mRNA Expression by UniProt/SwissProt for PRKCZ Gene

Q05513-KPCZ_HUMAN
Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis
genes like me logo Genes that share expressions with PRKCZ: view

In Situ Assay Products

Orthologs for PRKCZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCZ 35
  • 99.24 (n)
  • 99.81 (a)
cow
(Bos Taurus)
Mammalia PRKCZ 35
  • 88.74 (n)
  • 93.41 (a)
PRKCZ 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCZ 35
  • 89.11 (n)
  • 94.92 (a)
PRKCZ 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcz 35
  • 88.85 (n)
  • 95.61 (a)
Prkcz 16
Prkcz 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCZ 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcz 35
  • 88.74 (n)
  • 95.95 (a)
chicken
(Gallus gallus)
Aves PRKCZ 35
  • 78.43 (n)
  • 89.86 (a)
PRKCZ 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcz 35
  • 75.13 (n)
  • 86.45 (a)
zebrafish
(Danio rerio)
Actinopterygii prkcz 35
  • 74.04 (n)
  • 81.76 (a)
prkcz 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aPKC 36
  • 37 (a)
OneToMany
aPKC 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for PRKCZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCZ Gene

ENSEMBL:
Gene Tree for PRKCZ (if available)
TreeFam:
Gene Tree for PRKCZ (if available)

Paralogs for PRKCZ Gene

Paralogs for PRKCZ Gene

genes like me logo Genes that share paralogs with PRKCZ: view

Variants for PRKCZ Gene

Sequence variations from dbSNP and Humsavar for PRKCZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3052 -- 2,165,199(+) GGTGT(C/T)TTCCT intron-variant
rs12184 -- 2,056,554(+) AGGGA(C/T)GAAGG synonymous-codon, reference, intron-variant
rs169037 -- 2,164,143(-) TCAAC(A/C)AAAaa intron-variant
rs262639 -- 2,175,622(+) GGGCC(G/T)GGTGG intron-variant
rs262640 -- 2,175,323(+) AGCAT(A/C)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCZ Gene

Variant ID Type Subtype PubMed ID
dgv9e1 CNV Complex 17122850
dgv55n71 CNV Loss 21882294
dgv56n71 CNV Loss 21882294
nsv870914 CNV Loss 21882294
nsv834446 CNV Loss 17160897
dgv57n71 CNV Loss 21882294
dgv58n71 CNV Loss 21882294
nsv871701 CNV Loss 21882294
nsv822920 CNV Gain 20364138
esv2715695 CNV Deletion 23290073
nsv2520 CNV Insertion 18451855
nsv509479 CNV Insertion 20534489
nsv871663 CNV Loss 21882294
esv1002714 CNV Insertion 20482838
esv1162822 CNV Insertion 17803354
nsv3631 CNV Insertion 18451855
nsv470681 CNV Loss 18288195
esv2668737 CNV Deletion 23128226
esv27078 CNV Loss 19812545
nsv871399 CNV Loss 21882294
esv2715806 CNV Deletion 23290073
esv4759 CNV Deletion 18987735
dgv1e194 CNV Deletion 18987734
esv2715917 CNV Deletion 23290073
nsv160060 CNV Insertion 16902084
nsv460616 CNV Loss 19166990
esv2716028 CNV Deletion 23290073
esv2196740 CNV Deletion 18987734
esv2716140 CNV Deletion 23290073
nsv834557 CNV Loss 17160897
esv2492368 CNV Insertion 19546169
esv26913 CNV Gain+Loss 19812545
nsv821592 CNV Deletion 20802225
dgv6e201 CNV Deletion 23290073
dgv7e201 CNV Deletion 23290073
esv2505453 CNV Deletion 19546169
dgv8e201 CNV Deletion 23290073
esv4841 CNV Deletion 18987735
esv1008133 CNV Gain 20482838
esv1138741 CNV Deletion 17803354
esv2717473 CNV Deletion 23290073
esv2717584 CNV Deletion 23290073
nsv870901 CNV Gain 21882294
nsv870615 CNV Gain 21882294
dgv59n71 CNV Loss 21882294
esv2313378 CNV Deletion 18987734
esv4294 CNV Deletion 18987735
esv2717695 CNV Deletion 23290073
esv2717806 CNV Deletion 23290073
esv2717917 CNV Deletion 23290073
nsv461727 CNV Loss 19166990
dgv60n71 CNV Loss 21882294
dgv61n71 CNV Loss 21882294
dgv62n71 CNV Loss 21882294
esv2718028 CNV Deletion 23290073

Relevant External Links for PRKCZ Gene

HapMap Linkage Disequilibrium report
PRKCZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCZ Gene

Disorders for PRKCZ Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PRKCZ Gene including...

Search for PRKCZ Gene in MalaCards »

(15) Novoseek inferred disease relationships for PRKCZ Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 23.7 2
parainfluenza 22.7 2
necrosis 21.9 2
glioblastoma 11.2 2
pancreatic carcinoma 9.83 1

Relevant External Links for PRKCZ

Genetic Association Database (GAD)
PRKCZ
Human Genome Epidemiology (HuGE) Navigator
PRKCZ
genes like me logo Genes that share disorders with PRKCZ: view

No data available for UniProtKB/Swiss-Prot for PRKCZ Gene

Publications for PRKCZ Gene

  1. The cDNA sequence encoding human protein kinase C-zeta. (PMID: 8224878) Barbee J.L. … Burns D.J. (Gene 1993) 3 4 23
  2. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PMID: 9768361) Chou M.M. … Toker A. (Curr. Biol. 1998) 3 4 23
  3. Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. (PMID: 11035106) Monick M.M. … Hunninghake G.W. (J. Immunol. 2000) 3 4 23
  4. Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. (PMID: 18615853) Qin L. … Zhou J. (Diabetes Metab. Res. Rev. 2008) 3 23 48
  5. The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor. (PMID: 18668687) Frankenberg T. … Shneider B.L. (Hepatology 2008) 3 23

Products for PRKCZ Gene

  • Addgene plasmids for PRKCZ

Sources for PRKCZ Gene

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