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PRKCZ Gene

protein-coding   GIFtS: 70
GCID: GC01P001982

Protein Kinase C, Zeta

  See PRKCZ-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Zeta1 2     PKC-ZETA2
PKC22 3 5     Protein Kinase C Zeta Type2
nPKC-zeta2 3     EC 2.7.118
EC 2.7.11.133 8     

External Ids:    HGNC: 94121   Entrez Gene: 55902   Ensembl: ENSG000000676067   OMIM: 1769825   UniProtKB: Q055133   

Export aliases for PRKCZ gene to outside databases

Previous GC identifers: GC01P001538 GC01P001939 GC01P9M0003 GC01P001260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCZ Gene:
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a
variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC
isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and
diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot
be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module.
These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from
other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCZ Gene:
PRKCZ (protein kinase C, zeta) is a protein-coding gene. Diseases associated with PRKCZ include parainfluenza virus type 3. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved
in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and
maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following
mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade
independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an
adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and
contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose
transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its
kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in
interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in
TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads
to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and
is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and
dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In inflammatory response, is
required for the T-helper 2 (Th2) differentiation process, including interleukins production, efficient
activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in
development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes
by phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal
CA1 pyramidal cells

summary for PRKCZ Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCZ (Protein kinase M zeta/Protein kinase C zeta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCZ gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCZ promoter sequence
   Search Chromatin IP Primers for PRKCZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33-p36.2   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33-p36.2

PRKCZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001982:  view genomic region     (about GC identifiers)

Start:
1,981,909 bp from pter      End:
2,116,834 bp from pter
Size:
134,926 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513 (See protein sequence)
Recommended Name: Protein kinase C zeta type  
Size: 592 amino acids; 67660 Da
Subunit: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3.
Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of
a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary
complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts
(via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in
the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3
and TIAM1. Interacts with PDPK1 (via N-terminus region)
Sequence caution: Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K4N0 A8MU64 B7Z2J7 E9PCW2 Q15207 Q5SYT5 Q969S4
Alternative splicing: 3 isoforms:  Q05513-1   Q05513-2   Q05513-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKCZ: NX_Q05513

Explore proteomics data for PRKCZ at MOPED

Post-translational modifications: 

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is
    inhibited by the apoptotic C-terminus cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the
    kinase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCZ (Q05513) (see all 26)
     LHSCFQT  GHIKLTD  VNGGDLM  LIIHVFP 


    See PRKCZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001028753.1  NP_001028754.1  NP_001229803.1  NP_002735.3  

    ENSEMBL proteins: 
     ENSP00000367830   ENSP00000424945   ENSP00000421587   ENSP00000383712   ENSP00000427085  
     ENSP00000426412   ENSP00000462105   ENSP00000424228   ENSP00000421869   ENSP00000425643  
     ENSP00000425317   ENSP00000424763   ENSP00000421219   ENSP00000421350   ENSP00000422349  
     ENSP00000427134   ENSP00000422764   ENSP00000424398   ENSP00000383711  
    Reactome Protein details: Q05513

    PRKCZ Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCZ Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCZ
    OriGene Purified Proteins for PRKCZ
    OriGene Protein Over-expression Lysate for PRKCZ
    OriGene MassSpec for PRKCZ
    OriGene Custom Protein Services for PRKCZ
    GenScript Custom Purified and Recombinant Proteins Services for PRKCZ
    Novus Biologicals PRKCZ Proteins
    Novus Biologicals PRKCZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCZ 

    PRKCZ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCZ
    R&D Systems Antibodies for PRKCZ (PKC zeta)
    Cell Signaling Technology (CST) Antibodies for PRKCZ  (PKCZ)
    OriGene Antibodies for PRKCZ
    OriGene Custom Antibody Services for PRKCZ
    Novus Biologicals PRKCZ Antibodies
    Abcam antibodies for PRKCZ
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKCZ
    LSBio Antibodies in human, mouse, rat for PRKCZ

    PRKCZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCZ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKCZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, zeta
    Iota subfamily
    Protein kinase C

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR012233 PKC_zeta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05513

    ProtoNet protein and cluster: Q05513

    3 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Domain: The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B
    Domain: The C1 domain does not bind the diacylglycerol (DAG)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCZ_HUMAN, Q05513
    Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
    phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved
    in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and
    maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following
    mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade
    independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an
    adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and
    contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose
    transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its
    kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in
    interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in
    TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads
    to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and
    is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and
    dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In inflammatory response, is
    required for the T-helper 2 (Th2) differentiation process, including interleukins production, efficient
    activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in
    development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
    NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes
    by phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal
    CA1 pyramidal cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due
    to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol
    esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn
    motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a
    physiological activator (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity IDA15069075
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11260256
         
    Find genes that share ontologies with PRKCZ           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKCZ:
     Increased cell death HMECs cel  Increases Tamoxifen sensitivit 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Prkcz):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     no phenotypic analysis  pigmentation  vision/eye 

    Find genes that share phenotypes with PRKCZ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prkcztm1.1Msg for PRKCZ

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKCZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKCZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCZ

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PRKCZ using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PRKCZ:
    hsa-miR-448
    SwitchGear 3'UTR luciferase reporter plasmidPRKCZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKCZ
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCZ

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCZ (see all 24)
    OriGene ORF clones in mouse, rat for PRKCZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKCZ (NM_002744)
    Sino Biological Human cDNA Clone for PRKCZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCZ
    Addgene plasmids for PRKCZ 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKCZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCZ

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12238) for PRKCZ 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCZ_HUMAN, Q05513: Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the
    rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for
    its localization to the cell junction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane4
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm TAS7925449
    GO:0005768endosome IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with PRKCZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCZ About   (see all 98)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF4F0.44
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription Receptor mediated HIF regulation0.51
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    5IL-9 Signaling Pathways
    Development Thrombopoietin regulated cell processes0.38
    Adipocytokines and Insulin Signaling0.34


    Find genes that share SuperPaths with PRKCZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PRKCZ
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCZ (see all 74)
        UVB-Induced MAPK Signaling
    Intracellular Calcium Signaling
    NF-kappaB Activation by Viruses
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCZ
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCZ
        NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCZ (see all 21)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Translation Insulin regulation of translation

    Selected BioSystems Pathways for PRKCZ (see all 31)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway
    Insulin Signaling

    3 Sino Biological Pathways for PRKCZ
        EGFR Signaling Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    2 Reactome Pathways for PRKCZ
        TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
    GPVI-mediated activation cascade

    3 PharmGKB Pathways for PRKCZ
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCZ) (see all 8):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Endocytosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCZ (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              Type I Interferon Response in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCZ (Q055131, 2, 3 ENSP000003678304) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCQQ047591, 3, ENSP000002631254EBI-295351,EBI-374762 I2D: score=2 STRING: ENSP00000263125
    CCDC115Q96NT02, 3MINT-8267287 I2D: score=2 
    F11RQ9Y6242, 3MINT-4085708 I2D: score=2 
    HSP90AB1P082381, 3EBI-295351,EBI-352572 I2D: score=2 
    NMT2O605512, 3MINT-8267323 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001954positive regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation IDA10770950
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS8224878

    Find genes that share ontologies with PRKCZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKCZ
    10 ApexBio Compounds for PRKCZ     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCZ (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    1 IUPHAR Ligand for PRKCZ (protein kinase C, zeta)    About this table
    LigandTypeActionAffinityPubmed IDs
    arachidonic acid
    ActivatorActivation7744003

    Selected Novoseek inferred chemical compound relationships for PRKCZ gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 73.7 2 7639744 (1), 20236250 (1)
    phosphatidylinositol 69.4 21 10887180 (1), 12376338 (1), 17005646 (1), 11278885 (1) (see all 17)
    ly294002 65.1 2 19290459 (1), 12970779 (1)
    ceramide 57 8 10962008 (2), 16456021 (1), 9605434 (1), 19959757 (1) (see all 7)
    phosphoinositide 56.3 2 10528195 (1), 14500673 (1)
    okadaic acid 43 1 10781824 (1)
    phorbol 39.9 1 9169602 (1)
    serine 38.1 1 18202124 (1)
    c2ceramide 36.5 1 11679435 (1)
    rapamycin 34.9 1 18927238 (1)



    Find genes that share compounds with PRKCZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKCZ gene (4 alternative transcripts): 
    NM_001033581.1  NM_001033582.1  NM_001242874.1  NM_002744.4  

    Unigene Cluster for PRKCZ:

    Protein kinase C, zeta
    Hs.496255  [show with all ESTs]
    Unigene Representative Sequence: NM_002744
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000378567(uc001aiq.3) ENST00000468310 ENST00000484419 ENST00000503297
    ENST00000479566 ENST00000466651 ENST00000400921(uc001air.3) ENST00000495347
    ENST00000461106(uc010nyw.2) ENST00000461465 ENST00000470596 ENST00000496325
    ENST00000481140 ENST00000482686 ENST00000486681 ENST00000470986 ENST00000470511
    ENST00000471018
    miRNA
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    hsa-miR-448
    SwitchGear 3'UTR luciferase reporter plasmidPRKCZ 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRKCZ (NM_002744)
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    Addgene plasmids for PRKCZ 
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      QuantiFast Probe-based Assays in human, mouse, rat PRKCZ
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12238) for PRKCZ 

    Additional mRNA sequence: 

    AK097627.1 AK131526.1 AK290995.1 AK294649.1 AK294782.1 AK302160.1 AK310372.1 BC008058.2 
    BC014270.2 BC128516.1 BT007082.1 L14283.1 Z15108.1 

    Selected DOTS entries (see all 41):

    DT.449881  DT.75173685  DT.95267145  DT.100808988  DT.100037896  DT.95267152  DT.92450209  DT.95267155 
    DT.100742693  DT.121417966  DT.100815035  DT.92450220  DT.121417885  DT.75194260  DT.95267147  DT.100639808 
    DT.100685232  DT.92411816  DT.92450205  DT.92450207  DT.95234995  DT.121417805  DT.121417828  DT.75100734 

    Selected AceView cDNA sequences (see all 367):

    CB155525 BQ003414 BM055304 BM695824 BE898490 AI435266 BM696253 BU734096 
    BE304409 BM664518 BE394483 BU543815 AI221690 BM711266 AI760027 NM_002744 
    BM055025 BM841262 BQ446068 BP348843 BQ183175 CR594257 AI188467 BX094098 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
    SP1:              -                 -                 -     -     -     -     -     -     -     -     -     -     -     -           -                       -   
    SP2:                                                                                                        -     -     -           -                       -   
    SP3:                                                                                                        -     -     -           -                       -   
    SP4:                                                                                                                                -                       -   
    SP5:                                                                          -     -     -     -     -     -     -     -           -                       -   

    ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:  -     -     -     -     -                                                                                         -     -               
    SP2:  -     -     -     -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:  -                                                                                                                                       
    SP5:  -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for PRKCZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKCZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTTTCCAA
    PRKCZ Expression
    About this image


    PRKCZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
    PRKCZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496255

    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCZ (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              Type I Interferon Response in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKCZ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcz1 , 5 protein kinase C, zeta1, 5 88.85(n)1
    95.61(a)1
      4 (86.17 cM)5
    187621  NM_008860.31  NP_032886.21 
     1552601295 
    chicken
    (Gallus gallus)
    Aves PRKCZ1 protein kinase C, zeta 78.43(n)
    89.86(a)
      419399  XM_417561.4  XP_417561.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkcz1 protein kinase C, zeta 75.13(n)
    86.45(a)
      100101769  NM_001100265.1  NP_001093735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkcz1 protein kinase C, zeta 74.04(n)
    81.76(a)
      555737  NM_001030091.1  NP_001025262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aPKC3 oocyte determination protein
    serine/threonine more
    62(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-36
    Protein PKC-3 (pkc-3) mRNA, complete cds
    56(a)
    1 → many
    II(5380027-5384169) WBGene00004034
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKC16
    Protein serine/threonine kinase essential for cell...
    14(a)
    1 → many
    II(14241-17696) YBL105C


    ENSEMBL Gene Tree for PRKCZ (if available)
    TreeFam Gene Tree for PRKCZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCZ gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCZ using alignment to 16 protein entries:     KPCZ_HUMAN (see all proteins) (see all similar genes):
    PRKCI    PKN2    PRKCH    DMPK    PRKCB    MARK4
    RPS6KA5    AKT1    PKN1    SGK2    AKT3    PRKCG
    KIN27    RPS6KA3    PRKCE    PRKACB    NUAK1    PRKG1

    Find genes that share paralogs with PRKCZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PRKCZ (see all 3777)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423114
    A colorectal adenocarcinoma sample4--see VAR_0423112 R C mis40--------
    VAR_0354674
    A colorectal cancer sample4--see VAR_0354672 S F mis40--------
    rs1424259541,2
    --1979927(+) TGGCT-/GGTGCA 1 -- us2k10--------
    rs1806745131,2
    --1979927(+) GTGGCG/TGTGCA 1 -- us2k10--------
    rs1861618921,2
    C--1979957(+) AAGACA/GGAGGC 1 -- us2k10--------
    rs1909291211,2
    C--1979972(+) GCAGCA/CAAGAG 1 -- us2k10--------
    rs1448838531,2
    --1980128(+) TGGTTA/GGGAGC 1 -- us2k10--------
    rs751481171,2
    C,F--1980170(+) GCGGGC/ACAAAG 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1150747691,2
    F--1980185(+) AGGCTG/AGGGCT 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1479572101,2
    --1980190(+) GGGGCG/TCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKCZ (1981909 - 2116834 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKCZ (see all 55):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717917CNV Deletion23290073
    esv4759CNV Deletion18987735
    esv4294CNV Deletion18987735
    esv2716140CNV Deletion23290073
    dgv8e201CNV Deletion23290073
    esv2717473CNV Deletion23290073
    esv2715806CNV Deletion23290073
    esv2717806CNV Deletion23290073
    esv2668737CNV Deletion23128226
    dgv1e194CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCZ
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176982    OMIM disorders: --

    1 disease for PRKCZ:    
    About MalaCards
    parainfluenza virus type 3


    Find genes that share disorders with PRKCZ           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKCZ gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 23.7 2 15093250 (1), 11020447 (1)
    parainfluenza 22.7 2 7761474 (2)
    necrosis 21.9 2 11278885 (1), 12887331 (1)
    glioblastoma 11.2 2 19187446 (1), 10982151 (1)
    pancreatic carcinoma 9.83 1 7576113 (1)
    nasopharyngeal carcinoma 5.16 2 11284734 (1), 15670898 (1)
    tumors 5.09 4 11278885 (1), 16778206 (1), 11912160 (1), 8700129 (1)
    niddm 0 1 18615853 (1)
    leukemia 0 1 12105221 (1)
    breast cancer 0 2 19201988 (1), 15735031 (1)

    Genetic Association Database (GAD): PRKCZ
    Human Genome Epidemiology (HuGE) Navigator: PRKCZ (8 documents)

    Export disorders for PRKCZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PRKCZ gene, integrated from 10 sources (see all 438):
    (articles sorted by number of sources associating them with PRKCZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. (PubMed id 18615853)1, 4, 9 Qin L....Zhou J. (Diabetes Metab. Res. Rev. 2008)
    2. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PubMed id 9768361)1, 2, 9 Chou M.M.... Toker A. (Curr. Biol. 1998)
    3. The cDNA sequence encoding human protein kinase C-zeta. (PubMed id 8224878)1, 2, 9 Barbee J.L.... Burns D.J. (Gene 1993)
    4. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. (PubMed id 12887891)1, 2, 9 Wilson M.I.... Williams R.L. (Mol. Cell 2003)
    5. Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. (PubMed id 11035106)1, 2, 9 Monick M.M....Hunninghake G.W. (J. Immunol. 2000)
    6. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    9. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    10. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)1, 2 Hilton H.N.... Ormandy C.J. (Biochim. Biophys. Acta 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5590 HGNC: 9412 AceView: PRKCZ Ensembl:ENSG00000067606 euGenes: HUgn5590
    ECgene: PRKCZ Kegg: 5590 H-InvDB: PRKCZ

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCZ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKCZ gene:
    Search GeneIP for patents involving PRKCZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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