Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCZ Gene

protein-coding   GIFtS: 70
GCID: GC01P001982

protein kinase C, zeta
 Explore 39 diseases affiliated with
PRKCZ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKCZ    

Aliases
for PRKCZ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase C, Zeta1 2     PKC-ZETA2
PKC21 2 3 5     Protein Kinase C Zeta Type2
NPKC-Zeta1     EC 2.7.118
EC 2.7.11.133 8     

External Ids:    HGNC: 94121   Entrez Gene: 55902   Ensembl: ENSG000000676067   OMIM: 1769825   UniProtKB: Q055133   

Export aliases for PRKCZ gene to outside databases

Previous GC identifers: GC01P001538 GC01P001939 GC01P9M0003 GC01P001260


Summaries
for PRKCZ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKCZ:
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety
of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which
are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not
of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol
ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical
properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative
splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in
NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance
of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic
stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1
activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct
activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of
translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced
cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter
through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with
the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating
and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes,
forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity
along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12
cells. In inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukins
production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be
involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes by
phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal CA1
pyramidal cells

summary for PRKCZ:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCZ (Protein kinase M zeta/Protein kinase C zeta)


Genomic Views
for PRKCZ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCZ gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCZ promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33-p36.2   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33-p36.2

PRKCZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001982:  view genomic region     (about GC identifiers)

Start:
 1,981,909 bp from pter      End:
 2,116,834 bp from pter
Size:
 134,926 bases      Orientation:
 plus strand

Proteins
for PRKCZ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513 (See protein sequence)
Recommended Name: Protein kinase C zeta type  
Size: 592 amino acids; 67660 Da
Subunit: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a
complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex
with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex
composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts (via the
protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of
collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts
with PDPK1 (via N-terminus region)
Subcellular location: Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod
bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its
localization to the cell junction
Sequence caution: Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K4N0 A8MU64 Q15207 Q5SYT5 Q969S4
Alternative splicing: 2 isoforms:  Q05513-1   Q05513-2   

Explore the universe of human proteins at neXtProt for PRKCZ: NX_Q05513

Post-translational modifications:

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is
    • inhibited by the apoptotic C-terminus cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the
    kinase1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05513

    • 4/26 DME Specific Peptides for PRKCZ (Q05513) (see all 26)
     LHSCFQT  GHIKLTD  VNGGDLM  LIIHVFP 

    PRKCZ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001028753.1  NP_001028754.1  NP_001229803.1  NP_002735.3  

    ENSEMBL proteins: 
     ENSP00000367830   ENSP00000424945   ENSP00000421587   ENSP00000383712   ENSP00000427085  
     ENSP00000426412   ENSP00000462105   ENSP00000424228   ENSP00000421869   ENSP00000425643  
     ENSP00000425317   ENSP00000424763   ENSP00000421219   ENSP00000421350   ENSP00000422349  
     ENSP00000427134   ENSP00000422764   ENSP00000424398   ENSP00000383711  
    Reactome Protein details: Q05513
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PRKCZ Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCZ
    OriGene Purified Proteins (see all 2): PRKCZ
    OriGene Protein Over-expression Lysate (see all 3): PRKCZ
    OriGene Custom Protein Services for PRKCZ 
    GenScript Purified and Recombinant Proteins for PRKCZ
    Novus Biologicals PRKCZ Proteins
    Novus Biologicals PRKCZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/22 cellular component terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IEA--


    PRKCZ for ontologies           About GeneDecksing



    PRKCZ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCZ
    R&D Systems Antibodies for PRKCZ (PKC zeta)
    Cell Signaling Technology (CST) Antibodies for PRKCZ  (PKCZ)
    OriGene Antibodies (see all 3): PRKCZ
    OriGene Custom Antibody Services for PRKCZ 
    GenScript Superior Antibodies for PRKCZ
    Novus Biologicals PRKCZ Antibodies
    Abcam antibodies for PRKCZ 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for PRKCZ

    Assay Products for PRKCZ: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript PRKCZ-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PRKCZ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKCZ for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR012233 PKC_zeta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05513

    ProtoNet protein and cluster: Q05513

    3 Blocks protein families:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Domain: The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B
    Domain: The C1 domain does not bind the diacylglycerol (DAG)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Function
    for PRKCZ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Function: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in
    phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in
    NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance
    of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic
    stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1
    activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct
    activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of
    translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced
    cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter
    through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with
    the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating
    and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes,
    forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity
    along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12
    cells. In inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukins
    production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be
    involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In
    NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes by
    phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal CA1
    pyramidal cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the
    interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or
    calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be
    phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator
    (By similarity)

    Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): PRKCZ
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCZ
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRKCZ:
    hsa-miR-448
    SwitchGear 3'UTR luciferase reporter plasmid: PRKCZ 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCZ (see all 7)
    OriGene shRNA RFP: PRKCZ
    OriGene siRNA: PRKCZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCZ

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKCZ

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKCZ (NM_002744)
    Sino Biological Human cDNA Clone for PRKCZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCZ 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRKCZ
    Search LifeMap BioReagents cell lines for PRKCZ

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCZ

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity IDA15069075
    GO:0004697protein kinase C activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    PRKCZ for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PRKCZ:
     Increased cell death HMECs cel  Increases Tamoxifen sensitivit 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prkcz):
     hematopoietic system  homeostasis/metabolism  immune system  pigmentation  vision/eye 

    PRKCZ for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRKCZ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/93 super-pathways (see all 93) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 Pathway
    8/10 pathways (see all 10)
    		ErbB4 Pathway1.00
    		UVC-Induced MAPK Signaling0.44
    		ErbB Family Pathway0.59
    		LPS Stimulated MAPK Signaling0.36
    		Prolactin Signaling0.54
    		VEGF Signaling Pathway0.35
    		ErbB2-ErbB3 Heterodimers0.47
    		Growth Hormone Signaling0.32
    2Development_CNTF receptor signaling
    8/9 pathways (see all 9)
    		Transcription Receptor-mediated HIF regulation0.43
    		Translation Insulin regulation of translation0.35
    		Transcription_Receptor-mediated HIF regulation0.43
    		Translation _Regulation of EIF4F activity0.32
    		Regulation of lipid metabolism_Insulin signaling-generic cascades0.35
    		Translation Regulation activity of EIF4F0.32
    		Translation_Insulin regulation of translation0.35
    		Insulin signaling pathway0.17
    3CCR3 Pathway in Eosinophils
    		CCR3 Pathway in Eosinophils1.00
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Alpha-Adrenergic Signaling0.31
    		fMLP Pathway0.43
    		Huntington's Disease Pathway0.18
    4G-protein signaling_RAC1 in cellular process
    		G-protein signaling_RAC1 in cellular process1.00
    		Cytoskeleton remodeling CDC42 in cellular processes0.37
    		G-protein signaling RAC1 in cellular process1.00
    		CDC42 signaling events0.17
    		Cytoskeleton remodeling_CDC42 in cellular processes0.37
    5Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Bitter Taste Signaling0.44
    		Melatonin Signaling0.72
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/19 EMD Millipore Pathways for PRKCZ (see all 19)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Immune response CCR3 signaling in eosinophils
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 R&D Systems Pathways for PRKCZ
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling

    5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCZ (see all 74)
        UVB-Induced MAPK Signaling
    Intracellular Calcium Signaling
    NF-kappaB Activation by Viruses
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCZ
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCZ
        NF-kappaB Pathway
    VEGF Pathway

    5/21 GeneGo (Thomson Reuters) Pathways for PRKCZ (see all 21)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Translation Insulin regulation of translation

    5/32 BioSystems Pathways for PRKCZ (see all 32) 
        Wnt Signaling Pathway
    EGFR1 Signaling Pathway
    MAPK signaling pathway
    Signaling Pathways in Glioblastoma
    Calcium Regulation in the Cardiac Cell

    5/7        Reactome Pathways for PRKCZ (see all 7)
        Hemostasis
    Signaling by TGF-beta Receptor Complex
    Signal Transduction
    Platelet activation, signaling and aggregation
    Disassembly of tight junctions

    3 PharmGKB Pathways for PRKCZ
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5         Kegg Pathways  (Kegg details for PRKCZ):
        Chemokine signaling pathway
    Endocytosis
    Tight junction
    Insulin signaling pathway
    Type II diabetes mellitus


    PRKCZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/190 Interacting proteins for PRKCZ (Q055131, 2, 3 ENSP000003678304) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F11RQ9Y6242, 3, ENSP000002897794MINT-4085708 I2D: score=2 STRING: ENSP00000289779
    PRKCQQ047591, 3, ENSP000002631254EBI-295351,EBI-374762 I2D: score=2 STRING: ENSP00000263125
    CCDC115Q96NT02, 3MINT-8267287 I2D: score=2 
    HSP90AB1P082381, 3EBI-295351,EBI-352572 I2D: score=2 
    NMT2O605512, 3MINT-8267323 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0001954positive regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation IDA10770950
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS8224878


    PRKCZ for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKCZ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCZ for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCZ:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCZ

    Compounds for PRKCZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Glu27]-PKC (19-36)Inactive control peptide for PKC (19-36) (Cat. No. 4058)[309247-49-2]
    Phorbol 12,13-dibutyrate Protein kinase C activator[37558-16-0]
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]
    PKC (19-36)Pseudosubstrate peptide; inhibitor of PKC[113731-96-7]

    10/846 HMDB Compounds for PRKCZ (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    10/28 Novoseek chemical compound relationships for PRKCZ gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 73.7 2 7639744 (1), 20236250 (1)
    phosphatidylinositol 69.4 21 10887180 (1), 12376338 (1), 17005646 (1), 11278885 (1) (see all 17)
    ly294002 65.1 2 19290459 (1), 12970779 (1)
    ceramide 57 8 10962008 (2), 16456021 (1), 9605434 (1), 19959757 (1) (see all 7)
    phosphoinositide 56.3 2 10528195 (1), 14500673 (1)
    okadaic acid 43 1 10781824 (1)
    phorbol 39.9 1 9169602 (1)
    serine 38.1 1 18202124 (1)
    c2ceramide 36.5 1 11679435 (1)
    rapamycin 34.9 1 18927238 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCZ / KPCZ 

    Transcripts
    for PRKCZ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKCZ gene (4 alternative transcripts): 
    NM_001033581.1  NM_001033582.1  NM_001242874.1  NM_002744.4  

    Unigene Cluster for PRKCZ:

    Protein kinase C, zeta
    Hs.496255  [show with all ESTs]
    Unigene Representative Sequence: NM_002744
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000378567(uc001aiq.3) ENST00000468310 ENST00000484419 ENST00000503297
    ENST00000479566 ENST00000466651 ENST00000400921(uc001air.3) ENST00000495347
    ENST00000461106(uc010nyw.2) ENST00000461465 ENST00000470596 ENST00000496325
    ENST00000481140 ENST00000482686 ENST00000486681 ENST00000470986 ENST00000470511
    ENST00000471018

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): PRKCZ
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCZ
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRKCZ:
    hsa-miR-448
    SwitchGear 3'UTR luciferase reporter plasmid: PRKCZ 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCZ (see all 7)
    OriGene shRNA RFP: PRKCZ
    OriGene siRNA: PRKCZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCZ
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKCZ (NM_002744)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCZ 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKCZ
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCZ
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCZ
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCZ

    Additional cDNA sequence: 

    AK097627.1 AK131526.1 AK290995.1 AK294649.1 AK294782.1 AK302160.1 AK310372.1 BC008058.2 
    BC014270.2 BC128516.1 BT007082.1 L14283.1 Z15108.1 

    24/41 DOTS entries (see all 41):

    DT.449881  DT.75173685  DT.95267145  DT.100808988  DT.100037896  DT.95267152  DT.92450209  DT.95267155 
    DT.100742693  DT.121417966  DT.100815035  DT.92450220  DT.121417885  DT.75194260  DT.95267147  DT.100639808 
    DT.100685232  DT.92411816  DT.92450205  DT.92450207  DT.95234995  DT.121417805  DT.121417828  DT.75100734 

    24/367 AceView cDNA sequences (see all 367):

    BQ446068 AI188467 AK092409 AW027318 BM055025 BE898490 BE304409 BC008058 
    BC014270 AI435266 NM_002744 BU752466 BM562781 CK821048 BF992427 BQ003414 
    AI760027 AU156567 CR609425 AI627314 BM055304 BQ183175 AL538626 BX094098 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
    SP1:              -                 -                 -     -     -     -     -     -     -     -     -     -     -     -           -                       -   
    SP2:                                                                                                        -     -     -           -                       -   
    SP3:                                                                                                        -     -     -           -                       -   
    SP4:                                                                                                                                -                       -   
    SP5:                                                                          -     -     -     -     -     -     -     -           -                       -   

    ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:  -     -     -     -     -                                                                                         -     -               
    SP2:  -     -     -     -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:  -                                                                                                                                       
    SP5:  -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for PRKCZ

    Expression
    for PRKCZ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGTTTCCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKCZ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKCZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCZ

    SOURCE GeneReport for Unigene cluster: Hs.496255

    UniProtKB/Swiss-Prot: KPCZ_HUMAN, Q05513
    Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCZ (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              Type I Interferon Response in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKCZ
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCZ
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCZ
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCZ
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCZ

    Orthologs
    for PRKCZ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PRKCZ gene from 4/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRKCZ1 protein kinase C, zeta 78.43(n)
    89.86(a)    		   419399  XM_417561.3  XP_417561.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii prkcz1 protein kinase C, zeta 74.04(n)
    81.76(a)    		   555737  NM_001030091.1  NP_001025262.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta aPKC3 oocyte determination protein
    serine/threonine more    		 62(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea pkc-36
    		 Protein kinase C-like 3
    		 55(a)
    		 1 → many
    		 II(5380008-5384154)


    ENSEMBL Gene Tree for PRKCZ (if available)
    TreeFam Gene Tree for PRKCZ (if available) 

    Paralogs
    for PRKCZ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCZ gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    18/71 SIMAP similar genes for PRKCZ using alignment to 17 protein entries:     KPCZ_HUMAN (see all proteins) (see all similar genes):
    PRKCI    PKN2    PRKCB    MARK4    RPS6KA5    PRKCH
    AKT1    PKN1    SGK2    AKT3    KIN27    RPS6KA3
    PRKCG    PRKCE    PRKACB    NUAK1    AKT2    PRKACA

    PRKCZ for paralogs           About GeneDecksing



    Genomic Variants
    for PRKCZ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3089 NCBI SNPs in PRKCZ are shown (see all 3089)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2626901,2
    		C,F,--1389006(+) CCACCC/GCTGCT 1 -- ds50014Minor allele frequency- G:0.13MN WA NA 306
    rs1114904391,2
    		--1389008(+) ACCCCC/TGCTGC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs2626891,2
    		C,F,H,--1389092(-) CCTGCC/TGATAA 1 -- ut319Minor allele frequency- T:0.11NS NA 902
    rs1130657031,2
    		--1389158(+) CACAAC/TCCTGC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1122778671,2
    		C,--1390059(+) AGGGGC/TGGGCC 1 -- ut512Minor allele frequency- T:0.02WA 120
    rs749120211,2
    		C,F,--1390097(+) GAGAAC/TGNNNN 1 -- ut511Minor allele frequency- T:0.05NA 120
    rs763662481,2
    		F,--1390150(+) AATGAG/ATGAGT 1 -- ut511Minor allele frequency- A:0.03EA 120
    rs613434321,2
    		C,--1391648(+) TCTCAG/TCTCGA 2 -- us2k1 int12Minor allele frequency- T:0.02WA 120
    rs1136295891,2
    		C,--1391745(+) GCTGAG/CTTTCT 2 -- ut31 us2k11Minor allele frequency- C:0.50CSA 2
    rs32045501,2
    		C--1392030(+) ACCTTG/TGGCAG 2 -- ut31 us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for PRKCZ (1981909 - 2116834 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for PRKCZ
         9 CNVs: 4192 63811 43449 97254 74288 84004 63891 74292 3276
         13 Indels: 97253 84003 44501 24048 44493 42869 74290 74289 84006 74291 84005 41369 44494

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKCZ
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCZ

    Disorders / Diseases
    for PRKCZ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKCZ for disorders           About GeneDecksing

    OMIM gene information: 176982    OMIM disorders: --

    20/39 diseases for PRKCZ (see all 39):    About MalaCards
    parainfluenza virus type 3    soft tissue sarcoma    myofibrillar myopathy    intrahepatic cholangiocarcinoma
    insulin resistance    kaposi's sarcoma    alzheimer's disease    pancreatic carcinoma
    myopathy    nasopharyngitis    sarcoma    cholangiocarcinoma
    astrocytoma    breast cancer    pancreatitis    glioblastoma
    osteoporosis    obesity    cervical cancer    carcinoma

    10/15 Novoseek disease relationships for PRKCZ gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 23.7 2 15093250 (1), 11020447 (1)
    parainfluenza 22.7 2 7761474 (2)
    necrosis 21.9 2 11278885 (1), 12887331 (1)
    glioblastoma 11.2 2 19187446 (1), 10982151 (1)
    pancreatic carcinoma 9.83 1 7576113 (1)
    nasopharyngeal carcinoma 5.16 2 11284734 (1), 15670898 (1)
    tumors 5.09 4 11278885 (1), 16778206 (1), 11912160 (1), 8700129 (1)
    niddm 0 1 18615853 (1)
    leukemia 0 1 12105221 (1)
    breast cancer 0 2 19201988 (1), 15735031 (1)

    Genetic Association Database (GAD): PRKCZ
    Human Genome Epidemiology (HuGE) Navigator: PRKCZ (8 documents)

    Export disorders for PRKCZ gene to outside databases

    Publications
    for PRKCZ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCZ gene, integrated from 9 sources (see all 425):
    (articles sorted by number of sources associating them with PRKCZ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. (PubMed id 9768361)1, 2, 9 Chou M.M.... Toker A. (1998)
    2. The cDNA sequence encoding human protein kinase C-zeta. (PubMed id 8224878)1, 2, 9 Barbee J.L.... Burns D.J. (1993)
    3. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. (PubMed id 12887891)1, 2, 9 Wilson M.I.... Williams R.L. (2003)
    4. Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. (PubMed id 11035106)1, 2, 9 Monick M.M....Hunninghake G.W. (2000)
    5. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)1, 2 Hilton H.N.... Ormandy C.J. (2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Protein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes. (PubMed id 12970910)1, 4 Li Y.F....Fang F.D. (2003)
    10. Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. (PubMed id 12893243)1, 2 Zemlickova E.... Aitken A. (2003)

    External Searches for PRKCZ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKCZ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5590 HGNC: 9412 AceView: PRKCZ Ensembl:ENSG00000067606 euGenes: HUgn5590
    ECgene: PRKCZ Kegg: 5590 H-InvDB: PRKCZ

    Other Databases showing PRKCZ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKCZ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCZ Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PRKCZ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKCZ gene:
    Search GeneIP for patents involving PRKCZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRKCZ gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Purified and/or Recombinant PRKCZ Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PRKCZ
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCZ
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PRKCZ (PKC zeta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for PRKCZ   OriGene shRNA RFP for PRKCZ  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCZ   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKCZ  
     OriGene Protein Over-expression Lysate for PRKCZ   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PRKCZ   OriGene 3'-UTR Clone for PRKCZ  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCZ  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PRKCZ   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKCZ   OriGene Custom Protein Services for PRKCZ  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKCZ
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKCZ
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCZ
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCZ
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCZ
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCZ
     GenScript Purified and Recombinant Proteins for PRKCZ GenScript cDNA clones with any tag delivered in your preferred vector for PRKCZ
     GenScript PRKCZ-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for PRKCZ
     GenScript Custom overexpressing Cell Line Services for PRKCZ CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PRKCZ  (PKCZ)

     Regulatory tfbs in PRKCZ promoter
     Search Chromatin IP Primers for PRKCZ
     RT2 qPCR Primer Assay in human, mouse, rat PRKCZ
     GNC Network for PRKCZ
     SABiosciences PCR Arrays including human, mouse, rat PRKCZ
     Tocris compounds for PRKCZ
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for PRKCZ
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs/Proteins for PRKCZ
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRKCZ antibodies
     PRKCZ proteins
     PRKCZ lysates
     Antibodies for PRKCZ
     See all of Abcam's Antibodies, Kits and Proteins for PRKCZ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for PRKCZ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCZ
     SwitchGear 3'UTR luciferase reporter plasmids for PRKCZ
     SwitchGear Promoter luciferase reporter plasmids for PRKCZ
     ThermoFisher Antibodies for PRKCZ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCZ
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PRKCZ gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4