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Aliases for PRKCZ Gene

Aliases for PRKCZ Gene

  • Protein Kinase C Zeta 2 3
  • Protein Kinase C, Zeta 2 3 5
  • EC 2.7.11.13 4 63
  • NPKC-Zeta 3 4
  • PKC2 3 4
  • EC 2.7.11 63
  • PKC-ZETA 3

External Ids for PRKCZ Gene

Previous GeneCards Identifiers for PRKCZ Gene

  • GC01P001538
  • GC01P001939
  • GC01P9M0003
  • GC01P001260
  • GC01P001982

Summaries for PRKCZ Gene

Entrez Gene Summary for PRKCZ Gene

  • Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCZ Gene

PRKCZ (Protein Kinase C Zeta) is a Protein Coding gene. Diseases associated with PRKCZ include myofibrillar myopathy and chromosome 1p36 deletion syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCZ Gene

  • Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

Tocris Summary for PRKCZ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCZ Gene

Genomics for PRKCZ Gene

Regulatory Elements for PRKCZ Gene

Promoters for PRKCZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCZ on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKCZ Gene

Chromosome:
1
Start:
2,050,470 bp from pter
End:
2,185,395 bp from pter
Size:
134,926 bases
Orientation:
Plus strand

Genomic View for PRKCZ Gene

Genes around PRKCZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCZ Gene

Proteins for PRKCZ Gene

  • Protein details for PRKCZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05513-KPCZ_HUMAN
    Recommended name:
    Protein kinase C zeta type
    Protein Accession:
    Q05513
    Secondary Accessions:
    • A8K4N0
    • A8MU64
    • B7Z2J7
    • E9PCW2
    • Q15207
    • Q5SYT5
    • Q969S4

    Protein attributes for PRKCZ Gene

    Size:
    592 amino acids
    Molecular mass:
    67660 Da
    Quaternary structure:
    • Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts (via the protein kinase domain) with WWC1. Forms a tripartite complex with WWC1 and DDR1, but predominantly in the absence of collagen. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with PDPK1 (via N-terminal region). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with WDFY2 and VAMP2 (PubMed:17313651).
    SequenceCaution:
    • Sequence=CAA78813.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRKCZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCZ Gene

Proteomics data for PRKCZ Gene at MOPED

Post-translational modifications for PRKCZ Gene

  • CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCZ (PKCZ)

Domains & Families for PRKCZ Gene

Gene Families for PRKCZ Gene

Suggested Antigen Peptide Sequences for PRKCZ Gene

Graphical View of Domain Structure for InterPro Entry

Q05513

UniProtKB/Swiss-Prot:

KPCZ_HUMAN :
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The PB1 domain mediate mutually exclusive interactions with SQSTM1 and PARD6B.
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PB1 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with PRKCZ: view

Function for PRKCZ Gene

Molecular function for PRKCZ Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (By similarity).
UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at Ser-311. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

Enzyme Numbers (IUBMB) for PRKCZ Gene

Gene Ontology (GO) - Molecular Function for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019904 protein domain specific binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRKCZ: view
genes like me logo Genes that share phenotypes with PRKCZ: view

Animal Models for PRKCZ Gene

MGI Knock Outs for PRKCZ:

Animal Model Products

miRNA for PRKCZ Gene

miRTarBase miRNAs that target PRKCZ

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCZ Gene

Localization for PRKCZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCZ Gene

Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells. Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Colocalizes with VAMP2 and WDFY2 in intracellular vesicles. {ECO:0000269 PubMed:17313651}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCZ Gene COMPARTMENTS Subcellular localization image for PRKCZ gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
endosome 4
cytoskeleton 3
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005911 cell-cell junction IDA 20332120
GO:0005938 cell cortex IEA --
GO:0031941 filamentous actin IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PRKCZ: view

Pathways & Interactions for PRKCZ Gene

genes like me logo Genes that share pathways with PRKCZ: view

Pathways by source for PRKCZ Gene

SIGNOR curated interactions for PRKCZ Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IEA,IDA 10770950
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 8224878
genes like me logo Genes that share ontologies with PRKCZ: view

Drugs & Compounds for PRKCZ Gene

(20) Drugs for PRKCZ Gene - From: Novoseek, HMDB, DGIdb, ApexBio, Tocris, FDA Approved Drugs, IUPHAR, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 350
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Adenosine triphosphate Approved Nutra 0
arachidonic acid Experimental Nutra Activator 27

(25) Additional Compounds for PRKCZ Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PRKCZ: view

Drug Products

Transcripts for PRKCZ Gene

Unigene Clusters for PRKCZ Gene

Protein kinase C, zeta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCZ Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - -
SP11: - -
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - -
SP18: -
SP19: - - - - - - - - - - - -
SP20: - - - -
SP21: -
SP22:

ExUns: 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13: -
SP14: - - - - - - -
SP15:
SP16:
SP17: - - - - - - -
SP18:
SP19:
SP20: - - - - -
SP21: -
SP22:

Relevant External Links for PRKCZ Gene

GeneLoc Exon Structure for
PRKCZ
ECgene alternative splicing isoforms for
PRKCZ

Expression for PRKCZ Gene

mRNA expression in normal human tissues for PRKCZ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCZ Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8), Brain - Cerebellum (x4.6), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for PRKCZ Gene

This gene is overexpressed in Lung (38.3), Placenta (8.0), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCZ Gene



SOURCE GeneReport for Unigene cluster for PRKCZ Gene Hs.496255

mRNA Expression by UniProt/SwissProt for PRKCZ Gene

Q05513-KPCZ_HUMAN
Tissue specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.
genes like me logo Genes that share expression patterns with PRKCZ: view

Protein tissue co-expression partners for PRKCZ Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRKCZ Gene

Orthologs for PRKCZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCZ 35
  • 99.24 (n)
  • 99.81 (a)
cow
(Bos Taurus)
Mammalia PRKCZ 36
  • 93 (a)
OneToOne
PRKCZ 35
  • 88.74 (n)
  • 93.41 (a)
dog
(Canis familiaris)
Mammalia PRKCZ 35
  • 89.11 (n)
  • 94.92 (a)
PRKCZ 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcz 16
Prkcz 35
  • 88.85 (n)
  • 95.61 (a)
Prkcz 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCZ 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcz 35
  • 88.74 (n)
  • 95.95 (a)
chicken
(Gallus gallus)
Aves PRKCZ 35
  • 78.43 (n)
  • 89.86 (a)
PRKCZ 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcz 35
  • 75.13 (n)
  • 86.45 (a)
zebrafish
(Danio rerio)
Actinopterygii prkcz 35
  • 74.04 (n)
  • 81.76 (a)
prkcz 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aPKC 36
  • 37 (a)
OneToMany
aPKC 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for PRKCZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCZ Gene

ENSEMBL:
Gene Tree for PRKCZ (if available)
TreeFam:
Gene Tree for PRKCZ (if available)

Paralogs for PRKCZ Gene

Paralogs for PRKCZ Gene

genes like me logo Genes that share paralogs with PRKCZ: view

Variants for PRKCZ Gene

Sequence variations from dbSNP and Humsavar for PRKCZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035467 A colorectal cancer sample
rs56017162 - 2,056,541(+) GGCCC(A/G)TCAGT nc-transcript-variant, reference, missense
VAR_042311 A colorectal adenocarcinoma sample
rs35271800 - 2,055,515(-) GCAGA(C/T)GACAC nc-transcript-variant, reference, missense
rs3052 -- 2,165,199(+) GGTGT(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCZ Gene

Variant ID Type Subtype PubMed ID
dgv9e1 CNV Complex 17122850
dgv55n71 CNV Loss 21882294
dgv56n71 CNV Loss 21882294
nsv870914 CNV Loss 21882294
nsv834446 CNV Loss 17160897
dgv57n71 CNV Loss 21882294
dgv58n71 CNV Loss 21882294
nsv871701 CNV Loss 21882294
nsv822920 CNV Gain 20364138
esv2715695 CNV Deletion 23290073
nsv2520 CNV Insertion 18451855
nsv509479 CNV Insertion 20534489
nsv871663 CNV Loss 21882294
esv1002714 CNV Insertion 20482838
esv1162822 CNV Insertion 17803354
nsv3631 CNV Insertion 18451855
nsv470681 CNV Loss 18288195
esv2668737 CNV Deletion 23128226
esv27078 CNV Loss 19812545
nsv871399 CNV Loss 21882294
esv2715806 CNV Deletion 23290073
esv4759 CNV Deletion 18987735
dgv1e194 CNV Deletion 18987734
esv2715917 CNV Deletion 23290073
nsv160060 CNV Insertion 16902084
nsv460616 CNV Loss 19166990
esv2716028 CNV Deletion 23290073
esv2196740 CNV Deletion 18987734
esv2716140 CNV Deletion 23290073
nsv834557 CNV Loss 17160897
esv2492368 CNV Insertion 19546169
esv26913 CNV Gain+Loss 19812545
nsv821592 CNV Deletion 20802225
dgv6e201 CNV Deletion 23290073
dgv7e201 CNV Deletion 23290073
esv2505453 CNV Deletion 19546169
dgv8e201 CNV Deletion 23290073
esv4841 CNV Deletion 18987735
esv1008133 CNV Gain 20482838
esv1138741 CNV Deletion 17803354
esv2717473 CNV Deletion 23290073
esv2717584 CNV Deletion 23290073
nsv870901 CNV Gain 21882294
nsv870615 CNV Gain 21882294
dgv59n71 CNV Loss 21882294
esv2313378 CNV Deletion 18987734
esv4294 CNV Deletion 18987735
esv2717695 CNV Deletion 23290073
esv2717806 CNV Deletion 23290073
esv2717917 CNV Deletion 23290073
nsv461727 CNV Loss 19166990
dgv60n71 CNV Loss 21882294
dgv61n71 CNV Loss 21882294
dgv62n71 CNV Loss 21882294
esv2718028 CNV Deletion 23290073

Variation tolerance for PRKCZ Gene

Residual Variation Intolerance Score: 8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCZ Gene

HapMap Linkage Disequilibrium report
PRKCZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCZ Gene

Disorders for PRKCZ Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKCZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myofibrillar myopathy
  • alpha beta crystallinopathy
chromosome 1p36 deletion syndrome
  • 1p36 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRKCZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCZ

Genetic Association Database (GAD)
PRKCZ
Human Genome Epidemiology (HuGE) Navigator
PRKCZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCZ
genes like me logo Genes that share disorders with PRKCZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCZ Gene

Publications for PRKCZ Gene

  1. Genetic variants in protein kinase C zeta gene and type 2 diabetes risk: a case-control study of a Chinese Han population. (PMID: 18615853) Qin L. … Zhou J. (Diabetes Metab. Res. Rev. 2008) 3 23 48 67
  2. Beta-catenin regulates melanocyte dendricity through the modulation of PKCzeta and PKCdelta. (PMID: 20236250) Kim J.H. … Yoon T.J. (Pigment Cell Melanoma Res 2010) 3 23
  3. ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes. (PMID: 19809379) Chen F. … Shneider B.L. (Pediatr. Res. 2010) 3 23
  4. Reduction of protein kinase C zeta inhibits migration and invasion of human glioblastoma cells. (PMID: 19187446) Guo H. … Ma Y. (J. Neurochem. 2009) 3 23
  5. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. (PMID: 18094075) Jerde T.J. … Nakada S.Y. (Mol. Pharmacol. 2008) 3 23

Products for PRKCZ Gene