Free for academic non-profit institutions. Other users need a Commercial license

PRKCQ Gene(Protein Coding)

Protein Kinase C Theta

GCID:
GC10M006473
GIFtS:
73
Genes Participants
UDN Logo

Aliases for PRKCQ Gene

Aliases for PRKCQ Gene

  • Protein Kinase C Theta 2 3
  • Protein Kinase C, Theta 2 3 5
  • EC 2.7.11.13 4 63
  • NPKC-Theta 3 4
  • PRKCT 3 4
  • EC 2.7.11 63

External Ids for PRKCQ Gene

Previous GeneCards Identifiers for PRKCQ Gene

  • GC10M006413
  • GC10M006619
  • GC10M006509

Summaries for PRKCQ Gene

Entrez Gene Summary for PRKCQ Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCQ Gene

PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Gastrointestinal Stromal Tumor and Smallpox. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCQ Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Tocris Summary for PRKCQ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCQ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCQ Gene

Genomics for PRKCQ Gene

Products:

  1. Regulatory Element

Regulatory Elements for PRKCQ Gene

Enhancers for PRKCQ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRKCQ on UCSC Golden Path with GeneCards custom track

Promoters for PRKCQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCQ on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRKCQ gene promoter:

Genomic Location for PRKCQ Gene

Chromosome:
10
Start:
6,393,595 bp from pter
End:
6,580,646 bp from pter
Size:
187,052 bases
Orientation:
Minus strand

Genomic View for PRKCQ Gene

Genes around PRKCQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCQ Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRKCQ Gene

Proteins for PRKCQ Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRKCQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04759-KPCT_HUMAN
    Recommended name:
    Protein kinase C theta type
    Protein Accession:
    Q04759
    Secondary Accessions:
    • B4DF52
    • Q14DH6
    • Q3MJF1
    • Q64FY5
    • Q9H508
    • Q9H549

    Protein attributes for PRKCQ Gene

    Size:
    706 amino acids
    Molecular mass:
    81865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB.

    Three dimensional structures from OCA and Proteopedia for PRKCQ Gene

    Alternative splice isoforms for PRKCQ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCQ Gene

Proteomics data for PRKCQ Gene at MOPED

Protein Expression for PRKCQ Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PRKCQ Gene

Q04759:

Post-translational modifications for PRKCQ Gene

  • Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.
  • Ubiquitination at Lys 77, Lys 110, Lys 286, Lys 325, Lys 384, and Lys 527
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCQ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCQ (PKCT)
  • Cloud-Clone Corp. Antibodies for PRKCQ

Domains & Families for PRKCQ Gene

Gene Families for PRKCQ Gene

HGNC:
IUPHAR :

Protein Domains for PRKCQ Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04759

UniProtKB/Swiss-Prot:

KPCT_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCQ: view

Function for PRKCQ Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PRKCQ Gene

GENATLAS Biochemistry:
protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T lymphocytes
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Enzyme Numbers (IUBMB) for PRKCQ Gene

Phenotypes for PRKCQ Gene

MGI mutant phenotypes for PRKCQ:
inferred from 4 alleles
GenomeRNAi human phenotypes for PRKCQ:
genes like me logo Genes that share phenotypes with PRKCQ: view

Animal Models for PRKCQ Gene

MGI Knock Outs for PRKCQ:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRKCQ Gene

Localization for PRKCQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCQ Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCQ Gene COMPARTMENTS Subcellular localization image for PRKCQ gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for PRKCQ Gene

Pathways & Interactions for PRKCQ Gene

genes like me logo Genes that share pathways with PRKCQ: view

Pathways by source for PRKCQ Gene

1 GeneTex pathway for PRKCQ Gene
2 Cell Signaling Technology pathways for PRKCQ Gene
2 Tocris pathways for PRKCQ Gene

SIGNOR curated interactions for PRKCQ Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006509 membrane protein ectodomain proteolysis ISS --
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
genes like me logo Genes that share ontologies with PRKCQ: view

Drugs & Compounds for PRKCQ Gene

Products:

  1. Drug

(15) Drugs for PRKCQ Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 364
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Adenosine triphosphate Approved Nutra 0
Phosphonoserine Experimental Pharma Target 0

(11) Additional Compounds for PRKCQ Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCQ Gene

Compound Action Cas Number
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
PKC fragment (530-558) Potent activator of protein kinase C 122613-29-0
Pseudo RACK1 Protein kinase C activator peptide (attached to cell permeable vector)
SC-10 Protein kinase C activator 102649-79-6
SC-9 Protein kinase C activator 102649-78-5
genes like me logo Genes that share compounds with PRKCQ: view

Transcripts for PRKCQ Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PRKCQ Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKCQ Gene

Protein kinase C, theta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCQ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PRKCQ Gene

GeneLoc Exon Structure for
PRKCQ
ECgene alternative splicing isoforms for
PRKCQ

Expression for PRKCQ Gene

Products:

  1. Primer

mRNA expression in normal human tissues for PRKCQ Gene

mRNA expression in normal human tissues for PRKCQ Gene
mRNA expression by BioGPS for PRKCQ GenemRNA expression by GTEx for PRKCQ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCQ Gene

This gene is overexpressed in Muscle - Skeletal (x18.3) and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for PRKCQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.7) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCQ Gene



SOURCE GeneReport for Unigene cluster for PRKCQ Gene Hs.498570

mRNA Expression by UniProt/SwissProt for PRKCQ Gene

Q04759-KPCT_HUMAN
Tissue specificity: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.
genes like me logo Genes that share expression patterns with PRKCQ: view

Protein tissue co-expression partners for PRKCQ Gene

Primer Products

Orthologs for PRKCQ Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCQ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia PRKCQ 35
  • 89.19 (n)
  • 96.18 (a)
PRKCQ 36
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PRKCQ 35
  • 90.84 (n)
  • 96.74 (a)
PRKCQ 36
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Prkcq 35
  • 87.33 (n)
  • 94.89 (a)
Prkcq 16
Prkcq 36
  • 95 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia PRKCQ 35
  • 99.58 (n)
  • 99.72 (a)
PRKCQ 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Prkcq 35
  • 87.57 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
 Mammalia PRKCQ 36
  • 84 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PRKCQ 36
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PRKCQ 35
  • 77.32 (n)
  • 83.1 (a)
PRKCQ 36
  • 81 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia PRKCQ 36
  • 68 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii prkcq 35
  • 69.98 (n)
  • 75.18 (a)
prkcq 36
  • 73 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Pk17E 37
  • 33 (a)
Pkcdelta 36
  • 15 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea tpa-1 37
  • 47 (a)
tpa-1 36
  • 46 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 50 (a)
 OneToMany
Species with no ortholog for PRKCQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKCQ Gene

ENSEMBL:
Gene Tree for PRKCQ (if available)
TreeFam:
Gene Tree for PRKCQ (if available)

Paralogs for PRKCQ Gene

Paralogs for PRKCQ Gene

(57) SIMAP similar genes for PRKCQ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRKCQ: view

Variants for PRKCQ Gene

Sequence variations from dbSNP and Humsavar for PRKCQ Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2236379 - 6,485,181(-) AAGGC(C/T)GCCAT reference, missense
VAR_042319 A colorectal adenocarcinoma sample
rs45590231 - 6,485,253(+) CAGTA(A/T)CTCTT reference, missense
rs34524148 - 6,483,559(+) TTTAT(A/C/T)CACCT reference, missense
rs1537320 -- 6,469,791(-) CCTTA(A/T)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCQ Gene

Variant ID Type Subtype PubMed ID
nsv7198 OTHER Inversion 18451855
nsv5687 CNV Loss 18451855
nsv507533 CNV Insertion 20534489
nsv515823 CNV Loss 19592680
nsv5698 CNV Insertion 18451855

Variation tolerance for PRKCQ Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRKCQ Gene

Disorders for PRKCQ Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKCQ Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal stromal tumor
  • paraganglioma and gastric stromal sarcoma
smallpox
  • ordinary smallpox
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search PRKCQ in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCQ

Genetic Association Database (GAD)
PRKCQ
Human Genome Epidemiology (HuGE) Navigator
PRKCQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCQ
genes like me logo Genes that share disorders with PRKCQ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCQ Gene

Publications for PRKCQ Gene

  1. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PMID: 8444877) Baier G. … Altman A. (J. Biol. Chem. 1993) 2 3 4 67
  2. NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. (PMID: 20164171) Srivastava R. … Shimizu Y. (J. Biol. Chem. 2010) 3 23
  3. Protein kinase C-theta mediates negative feedback on regulatory T cell function. (PMID: 20339032) Zanin-Zhorov A. … Dustin M.L. (Science 2010) 3 23
  4. Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. (PMID: 18521081) Ou W.B. … Fletcher J.A. (Oncogene 2008) 3 23
  5. Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. (PMID: 18802085) Beal A.M. … Sykulev Y. (J. Immunol. 2008) 3 23

Products for PRKCQ Gene

  • Addgene plasmids for PRKCQ