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Aliases for PRKCQ Gene

Aliases for PRKCQ Gene

  • Protein Kinase C Theta 2 3 5
  • EC 2.7.11.13 4 58
  • NPKC-Theta 3 4
  • PRKCT 3 4
  • Protein Kinase C Theta Type 3
  • Protein Kinase C, Theta 2
  • EC 2.7.11 58

External Ids for PRKCQ Gene

Previous GeneCards Identifiers for PRKCQ Gene

  • GC10M006413
  • GC10M006619
  • GC10M006509

Summaries for PRKCQ Gene

Entrez Gene Summary for PRKCQ Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCQ Gene

PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Gastrointestinal Stromal Tumor and Smallpox. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development Slit-Robo signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCD.

UniProtKB/Swiss-Prot for PRKCQ Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Tocris Summary for PRKCQ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCQ Gene

Additional gene information for PRKCQ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCQ Gene

Genomics for PRKCQ Gene

Regulatory Elements for PRKCQ Gene

Enhancers for PRKCQ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H006541 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +36.7 36714 5 PKNOX1 FOXA2 BMI1 RUNX3 IKZF2 ZNF687 HLF NR2F1 FOXA3 TRIM22 PRKCQ PRKCQ-AS1 GC10M006507 GC10P006574
GH10H006470 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +107.1 107115 5 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ZNF143 FOS RUNX3 FAM208B PRKCQ PRKCQ-AS1 LOC105376384 RBM17 FBXO18 ENSG00000226647 NRBF2P5 PFKFB3 IL15RA
GH10H006528 0.8 FANTOM5 ENCODE dbSUPER 27.2 +50.0 49991 4 PRKCQ PRKCQ-AS1 GC10M006525 GC10M006507
GH10H006590 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -12.2 -12193 3 POLR2A SCRT2 ATF7 IKZF2 PRKCQ GC10M006583 GC10P006595
GH10H006497 1.1 FANTOM5 ENCODE dbSUPER 15.2 +81.6 81584 2 FOSL1 PKNOX1 ZNF26 PRKCQ NRBF2P5 LOC105376384 PRKCQ-AS1 FAM208B RBM17 PFKFB3 GC10P006490 GC10M006525
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCQ on UCSC Golden Path with GeneCards custom track

Promoters for PRKCQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024021 146 1801 ARNT SIN3A DMAP1 GLIS2 ZNF143 ATF7 SP3 REST ZNF592 KAT8

Genomic Location for PRKCQ Gene

Chromosome:
10
Start:
6,393,595 bp from pter
End:
6,580,646 bp from pter
Size:
187,052 bases
Orientation:
Minus strand

Genomic View for PRKCQ Gene

Genes around PRKCQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCQ Gene

Proteins for PRKCQ Gene

  • Protein details for PRKCQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04759-KPCT_HUMAN
    Recommended name:
    Protein kinase C theta type
    Protein Accession:
    Q04759
    Secondary Accessions:
    • B4DF52
    • Q14DH6
    • Q3MJF1
    • Q64FY5
    • Q9H508
    • Q9H549

    Protein attributes for PRKCQ Gene

    Size:
    706 amino acids
    Molecular mass:
    81865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB.

    Three dimensional structures from OCA and Proteopedia for PRKCQ Gene

    Alternative splice isoforms for PRKCQ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCQ Gene

Selected DME Specific Peptides for PRKCQ Gene

Q04759:
  • KVANLCGINQKL
  • PPFRPKVKSP
  • GKGSFGKV
  • GHIKIAD
  • DDDVECTMVEKRVL
  • WGLNKQGY
  • GVLLYEM
  • DFGMCKE
  • IDMPHRFK
  • VMEYLNGGD
  • HCGTLLWGL
  • FAIKALKK
  • YRDLKLDN
  • GTPDYIAPE
  • LDKDGHIK
  • CNAAIHKKCIDK
  • TFCGTPDYIAPEI
  • QKKPTMYP
  • VDWWSFGVLLYEML
  • YIAPEIL
  • GQSPFHG
  • RDLKLDN

Post-translational modifications for PRKCQ Gene

  • Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.
  • Ubiquitination at Lys77, isoforms=2110, Lys286, isoforms=2, 3325, Lys384, and isoforms=2, 3527
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCQ (PKCT)
  • Cloud-Clone Corp. Antibodies for PRKCQ

Domains & Families for PRKCQ Gene

Gene Families for PRKCQ Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q04759

UniProtKB/Swiss-Prot:

KPCT_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCQ: view

Function for PRKCQ Gene

Molecular function for PRKCQ Gene

GENATLAS Biochemistry:
protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T lymphocytes
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Enzyme Numbers (IUBMB) for PRKCQ Gene

Phenotypes From GWAS Catalog for PRKCQ Gene

Gene Ontology (GO) - Molecular Function for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
GO:0004697 protein kinase C activity IEA --
GO:0005515 protein binding IPI 10383400
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKCQ: view
genes like me logo Genes that share phenotypes with PRKCQ: view

Animal Models for PRKCQ Gene

MGI Knock Outs for PRKCQ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCQ
  • Applied Biological Materials Clones for PRKCQ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRKCQ Gene

Localization for PRKCQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCQ Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCQ gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005622 intracellular IBA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKCQ: view

Pathways & Interactions for PRKCQ Gene

genes like me logo Genes that share pathways with PRKCQ: view

Pathways by source for PRKCQ Gene

SIGNOR curated interactions for PRKCQ Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8444877
GO:0002376 immune system process IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006468 protein phosphorylation IEA --
GO:0006509 membrane protein ectodomain proteolysis ISS --
genes like me logo Genes that share ontologies with PRKCQ: view

Drugs & Compounds for PRKCQ Gene

(19) Drugs for PRKCQ Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 399
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Phosphonothreonine Experimental Pharma Target 0
phosphoserine Experimental Pharma Target 0

(7) Additional Compounds for PRKCQ Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCQ Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
genes like me logo Genes that share compounds with PRKCQ: view

Transcripts for PRKCQ Gene

Unigene Clusters for PRKCQ Gene

Protein kinase C, theta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCQ
  • Applied Biological Materials Clones for PRKCQ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCQ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PRKCQ Gene

GeneLoc Exon Structure for
PRKCQ
ECgene alternative splicing isoforms for
PRKCQ

Expression for PRKCQ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCQ Gene

mRNA differential expression in normal tissues according to GTEx for PRKCQ Gene

This gene is overexpressed in Muscle - Skeletal (x18.3) and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for PRKCQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.7) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCQ Gene



Protein tissue co-expression partners for PRKCQ Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKCQ Gene:

PRKCQ

SOURCE GeneReport for Unigene cluster for PRKCQ Gene:

Hs.498570

mRNA Expression by UniProt/SwissProt for PRKCQ Gene:

Q04759-KPCT_HUMAN
Tissue specificity: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.

Evidence on tissue expression from TISSUES for PRKCQ Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PRKCQ: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCQ Gene

Orthologs for PRKCQ Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCQ 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia PRKCQ 33 34
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia PRKCQ 33 34
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Prkcq 33
  • 87.57 (n)
mouse
(Mus musculus)
Mammalia Prkcq 33 16 34
  • 87.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCQ 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCQ 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCQ 33 34
  • 77.32 (n)
lizard
(Anolis carolinensis)
Reptilia PRKCQ 34
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prkcq 33 34
  • 69.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 35
  • 33 (a)
Pkcdelta 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tpa-1 35 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToMany
Species where no ortholog for PRKCQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKCQ Gene

ENSEMBL:
Gene Tree for PRKCQ (if available)
TreeFam:
Gene Tree for PRKCQ (if available)

Paralogs for PRKCQ Gene

Variants for PRKCQ Gene

Sequence variations from dbSNP and Humsavar for PRKCQ Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_042319 A colorectal adenocarcinoma sample
rs1000027317 -- 6,471,121(+) ATGAT(C/T)TACAG intron-variant
rs1000039652 -- 6,551,351(+) GTGTC(C/T)GCATA intron-variant
rs1000061540 -- 6,471,370(+) AGCCT(A/G)AGCGT intron-variant
rs1000062107 -- 6,509,605(+) GGTAT(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCQ Gene

Variant ID Type Subtype PubMed ID
nsv1047309 CNV gain 25217958
nsv1053177 CNV loss 25217958
nsv1161925 CNV deletion 26073780
nsv507533 OTHER sequence alteration 20534489
nsv515823 CNV loss 19592680
nsv549912 CNV gain 21841781
nsv5687 CNV deletion 18451855
nsv5698 CNV insertion 18451855
nsv7198 OTHER inversion 18451855

Variation tolerance for PRKCQ Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCQ Gene

Human Gene Mutation Database (HGMD)
PRKCQ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCQ Gene

Disorders for PRKCQ Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKCQ Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal stromal tumor
  • paraganglioma and gastric stromal sarcoma
smallpox
  • ordinary smallpox
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search PRKCQ in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCQ

Genetic Association Database (GAD)
PRKCQ
Human Genome Epidemiology (HuGE) Navigator
PRKCQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCQ
genes like me logo Genes that share disorders with PRKCQ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCQ Gene

Publications for PRKCQ Gene

  1. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). (PMID: 15364919) Li Y … Polakiewicz RD (The Journal of biological chemistry 2004) 3 4 22 60
  2. Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. (PMID: 11772397) Liu Y … Shaw S (The Biochemical journal 2002) 3 4 22 60
  3. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. (PMID: 11342610) Villalba M … Altman A (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 22 60
  4. Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. (PMID: 10652356) Liu Y … Altman A (The Journal of biological chemistry 2000) 3 4 22 60
  5. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PMID: 8444877) Baier G … Altman A (The Journal of biological chemistry 1993) 2 3 4 60

Products for PRKCQ Gene

  • Addgene plasmids for PRKCQ

Sources for PRKCQ Gene

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