Aliases for PRKCQ Gene
Aliases for PRKCQ Gene
External Ids for PRKCQ Gene
- HGNC: 9410
- Entrez Gene: 5588
- Ensembl: ENSG00000065675
- OMIM: 600448
- UniProtKB: Q04759
Previous GeneCards Identifiers for PRKCQ Gene
- GC10M006413
- GC10M006619
- GC10M006509
Summaries for PRKCQ Gene
-
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKCQ Gene
PRKCQ (Protein Kinase C Theta) is a Protein Coding gene. Diseases associated with PRKCQ include Gastrointestinal Stromal Tumor and Smallpox. Among its related pathways are VEGF Signaling Pathway and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCD.
UniProtKB/Swiss-Prot for PRKCQ Gene
-
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.
-
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.
Additional gene information for PRKCQ Gene
- Monarch Initiative
- Search for PRKCQ at DataMed
- Search for PRKCQ at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCQ Gene
Genomics for PRKCQ Gene
GeneHancer (GH) Regulatory Elements for PRKCQ Gene
Regulatory Element Products
Genomic Locations for PRKCQ Gene
- chr10:6,393,595-6,580,646
- (GRCh38/hg38)
- Size:
- 187,052 bases
- Orientation:
- Minus strand
- chr10:6,469,105-6,622,263
- (GRCh37/hg19)
Genomic View for PRKCQ Gene
- Cytogenetic band:
-
- 10p15.1 by Ensembl
- 10p15.1 by Entrez Gene
- 10p15.1 by HGNC


RefSeq DNA sequence for PRKCQ Gene
Proteins for PRKCQ Gene
-
Protein details for PRKCQ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04759-KPCT_HUMAN
- Recommended name:
- Protein kinase C theta type
- Protein Accession:
- Q04759
- B4DF52
- Q14DH6
- Q3MJF1
- Q64FY5
- Q9H508
- Q9H549
Protein attributes for PRKCQ Gene
- Size:
- 706 amino acids
- Molecular mass:
- 81865 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB.
Three dimensional structures from OCA and Proteopedia for PRKCQ Gene
Protein Expression for PRKCQ Gene
Selected DME Specific Peptides for PRKCQ Gene
- Q04759:
-
- KVANLCGINQKL
- PPFRPKVKSP
- GKGSFGKV
- GHIKIAD
- DDDVECTMVEKRVL
- WGLNKQGY
- GVLLYEM
- DFGMCKE
- IDMPHRFK
- VMEYLNGGD
- HCGTLLWGL
- FAIKALKK
- YRDLKLDN
- GTPDYIAPE
- LDKDGHIK
- CNAAIHKKCIDK
- TFCGTPDYIAPEI
- QKKPTMYP
- VDWWSFGVLLYEML
- YIAPEIL
- GQSPFHG
- RDLKLDN
Post-translational modifications for PRKCQ Gene
- Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.
- Ubiquitination at Lys77, Lys110, isoforms=2, 3286, Lys325, isoforms=2, 3384, and isoforms=2, 3527
Other Protein References for PRKCQ Gene
Antibody Products
- R&D Systems Antibodies for PRKCQ (PKC theta)
- Cell Signaling Technology (CST) Antibodies for PRKCQ (PKCT)
- Novus Biologicals Antibodies for PRKCQ
-
Cloud-Clone Corp. Antibodies for PRKCQ
- Invitrogen Antibodies for PRKCQ
- antibodies-online: Search results for 250 available PKC theta Antibodies ranked by validation data
- Compare Top PKC theta Antibodies
-
Recommended
- 5 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 7 IHC Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 88 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 92 WB Antibodies (anti-mouse)
- 1 ICS Antibody (anti-human)
- 12 IHC Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 162 WB Antibodies (anti-human)
- GeneTex PRKCQ antibody for PRKCQ
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRKCQ
Protein Products
-
OriGene Purified Proteins for PRKCQ
- Search Origene for MassSpec and Protein Over-expression Lysates for PRKCQ
- Origene Custom Protein Services for PRKCQ
-
Cloud-Clone Corp. Proteins for PRKCQ
- Search GeneTex for Proteins for PRKCQ
-
Abcam proteins for PRKCQ
Assay Products
Domains & Families for PRKCQ Gene
Gene Families for PRKCQ Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for PRKCQ Gene
Suggested Antigen Peptide Sequences for PRKCQ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q04759UniProtKB/Swiss-Prot:
KPCT_HUMAN :- The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
- Domain:
-
- The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
- Family:
-
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Function for PRKCQ Gene
Molecular function for PRKCQ Gene
- GENATLAS Biochemistry:
- protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T lymphocytes
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.
- UniProtKB/Swiss-Prot Function:
- Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.
Enzyme Numbers (IUBMB) for PRKCQ Gene
Phenotypes From GWAS Catalog for PRKCQ Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA,TAS | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
GO:0004697 | protein kinase C activity | IEA | -- |
GO:0005515 | protein binding | IPI | 10383400 |
GO:0005524 | ATP binding | IEA | -- |
Phenotypes for PRKCQ Gene
- MGI mutant phenotypes for PRKCQ:
-
inferred from 5 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- pigmentation phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for PRKCQ:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with imatinib mesylate
- Increased viability with SS1P at EC90
- Increased cell viability after pRB stimulation
- Increased viability with TRAIL
- Decreased substrate adherent cell growth
- Decreased interferon-beta reporter expression
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Apoptosis resistance
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Decreased telomerase activity
Animal Models for PRKCQ Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRKCQ
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRKCQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKCQ gene
- Search ViGene Biosciences for PRKCQ
CRISPR Products
-
OriGene CRISPR knockouts for PRKCQ
- genomics-online: gRNA clones - Search results for 93 available PKC theta gene related products
- Overview of 93 available PKC theta gene related products
- Applied Biological Materials CRISPR for PRKCQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKCQ
- GenScript: Design CRISPR guide RNA sequences for PRKCQ
miRNA Products
- Search ViGene Biosciences for PRKCQ
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRKCQ
- Browse OriGene Inhibitory RNA Products For PRKCQ
- genomics-online: shRNA clones - Search results for 93 available PKC theta gene related products
- Overview of 93 available PKC theta gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKCQ gene
Clone Products
- Sino Biological Human cDNA Clone for PRKCQ
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRKCQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRKCQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRKCQ
- Applied Biological Materials Clones for PRKCQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRKCQ
-
ViGene Biosciences adenoviral particle packaged cDNA for PRKCQ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRKCQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKCQ gene
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRKCQ Gene
Localization for PRKCQ Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRKCQ Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
- Microtubule organizing center (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001772 | immunological synapse | IEA | -- |
GO:0005622 | intracellular | IBA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005815 | microtubule organizing center | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for PRKCQ Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
.59
|
.48
.37
|
2 | fMLP Pathway |
.43
|
.39
|
3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
4 | Sweet Taste Signaling |
.37
|
|
5 | Immune response NFAT in immune response |
Pathways by source for PRKCQ Gene
1 GeneTex pathway for PRKCQ Gene
2 Cell Signaling Technology pathways for PRKCQ Gene
19 BioSystems pathways for PRKCQ Gene
26 Reactome pathways for PRKCQ Gene
2 PharmGKB pathways for PRKCQ Gene
10 KEGG pathways for PRKCQ Gene
18 GeneGo (Thomson Reuters) pathways for PRKCQ Gene
5 R&D Systems pathways for PRKCQ Gene
2 Tocris pathways for PRKCQ Gene
Interacting Proteins for PRKCQ Gene
SIGNOR curated interactions for PRKCQ Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | NAS | 8444877 |
GO:0002376 | immune system process | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006509 | membrane protein ectodomain proteolysis | ISS | -- |
Drugs & Compounds for PRKCQ Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 | |||
Tamoxifen | Approved | Pharma | Antagonist, Target | TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens | 408 | |
Ingenol Mebutate | Approved | Pharma | 0 | |||
nolvadex | Approved October 1998 | Pharma | 0 | |||
Magnesium | Approved | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
Diglycerides Group A |
|
|||||
Diglycerides Group B |
|
|
||||
Diglycerides Group C |
|
|
|
|||
Diglycerides Group D |
|
|
(5) Tocris Compounds for PRKCQ Gene
Compound | Action | Cas Number |
---|---|---|
Calphostin C | Potent, selective and photo-dependent PKC inhibitor | 121263-19-2 |
CGP 53353 | Selective inhibitor of PKCbetaII | 145915-60-2 |
GF 109203X | Protein kinase C inhibitor | 133052-90-1 |
Oncrasin 1 | Induces abnormal nuclear aggregation of PKCiota; proapoptotic | 75629-57-1 |
Rottlerin | Reported PKCdelta inhibitor | 82-08-6 |
Transcripts for PRKCQ Gene
mRNA/cDNA for PRKCQ Gene
- (12) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRKCQ Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRKCQ
- genomics-online: gRNA clones - Search results for 93 available PKC theta gene related products
- Overview of 93 available PKC theta gene related products
- Applied Biological Materials CRISPR for PRKCQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRKCQ
- GenScript: Design CRISPR guide RNA sequences for PRKCQ
miRNA Products
- Search ViGene Biosciences for PRKCQ
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRKCQ
- Browse OriGene Inhibitory RNA Products For PRKCQ
- genomics-online: shRNA clones - Search results for 93 available PKC theta gene related products
- Overview of 93 available PKC theta gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRKCQ gene
Clone Products
- Sino Biological Human cDNA Clone for PRKCQ
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRKCQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRKCQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRKCQ
- Applied Biological Materials Clones for PRKCQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - |
Expression for PRKCQ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Hypothalamus
- Hippocampus
- Thalamus
- Cerebellum
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Bone (Muscoskeletal System)
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Head Mesenchyme (Muscoskeletal System)
- Neural Tube (Nervous System)
- Spinal Cord (Nervous System)
-
Liver (Hepatobiliary System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for PRKCQ Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCQ Gene
NURSA nuclear receptor signaling pathways regulating expression of PRKCQ Gene:
PRKCQSOURCE GeneReport for Unigene cluster for PRKCQ Gene:
Hs.498570mRNA Expression by UniProt/SwissProt for PRKCQ Gene:
Q04759-KPCT_HUMANEvidence on tissue expression from TISSUES for PRKCQ Gene
- Blood(4.4)
- Nervous system(4.4)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for PRKCQ
- genomics-online: primer clones - Search results for 93 available PKC theta gene related products
- Overview of 93 available PKC theta gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCQ Gene
Orthologs for PRKCQ Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PRKCQ 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PRKCQ 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PRKCQ 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Prkcq 33 |
|
||
mouse (Mus musculus) |
Mammalia | Prkcq 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | PRKCQ 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | PRKCQ 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PRKCQ 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PRKCQ 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | prkcq 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Pk17E 35 |
|
|
|
Pkcdelta 34 |
|
OneToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | tpa-1 35 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PRKCQ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PRKCQ Gene
Paralogs for PRKCQ Gene
(57) SIMAP similar genes for PRKCQ Gene using alignment to 2 proteins:
- PRKCD
- PRKD1
- MARK4
- PRKCH
- RPS6KB1
- KIN27
- AKT1
- PRKACB
- PRKCE
- NUAK1
- STK32A
- PRKACG
- SGK2
- RPS6KA2
- RPS6KA4
- RPS6KA1
- PKN1
- PRKACA
- AKT2
- SGKL
- SGK3
- PRKG1
- DKFZp781N0293
- CDC42BPB
- PRKY
- AKT3
- PRKCZ
- RPS6KB2
- PRKX
- PKN2
- STK32B
- RPS6KA3
- PRKG2
- DKFZp564L2416
- PRKCA
- SGK1
- PkB-like 1
- PKN3
- PRKCI
- PRKAA1
- PDPK2
- PAK4
- NEK3
- STK32C
- PRKCB
- AURKC
- AURKB
- PRKCG
- CDK4
- STK11
- MST094
- AURKA
- STK38L
- MYO3A
- STK17A
- CDC2
- DAPK2
Variants for PRKCQ Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_042319 | A colorectal adenocarcinoma sample | p.Lys240Asn | |||
rs1000027317 | -- | 6,471,121(-) | C/T | intron_variant | |
rs1000039652 | -- | 6,551,351(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
rs1000061540 | -- | 6,471,370(-) | G/A | intron_variant | |
rs1000062107 | -- | 6,509,605(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1047309 | CNV | gain | 25217958 |
nsv1053177 | CNV | loss | 25217958 |
nsv1161925 | CNV | deletion | 26073780 |
nsv507533 | OTHER | sequence alteration | 20534489 |
nsv515823 | CNV | loss | 19592680 |
nsv549912 | CNV | gain | 21841781 |
nsv5687 | CNV | deletion | 18451855 |
nsv5698 | CNV | insertion | 18451855 |
nsv7198 | OTHER | inversion | 18451855 |
Additional Variant Information for PRKCQ Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCQ Gene
Disorders for PRKCQ Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
gastrointestinal stromal tumor |
|
|
smallpox |
|
|
wegener granulomatosis |
|
|
Additional Disease Information for PRKCQ
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCQ Gene
Publications for PRKCQ Gene
- Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). (PMID: 15364919) Li Y … Polakiewicz RD (The Journal of biological chemistry 2004) 3 4 22 58
- Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. (PMID: 11772397) Liu Y … Shaw S (The Biochemical journal 2002) 3 4 22 58
- Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. (PMID: 11342610) Villalba M … Altman A (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 22 58
- Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. (PMID: 10652356) Liu Y … Altman A (The Journal of biological chemistry 2000) 3 4 22 58
- Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PMID: 8444877) Baier G … Altman A (The Journal of biological chemistry 1993) 2 3 4 58
Products for PRKCQ Gene
- R&D Systems Antibodies for PRKCQ (PKC theta)
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- Invitrogen Antibodies for PRKCQ
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for PRKCQ
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRKCQ
- antibodies-online: Search results for 250 available PKC theta Antibodies ranked by validation data
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- Recommended
- 162 WB Antibodies (anti-human)
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- 5 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 ICS Antibody (anti-human)
- 92 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 88 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 7 IHC Antibodies (anti-rat)
- antibodies-online: Search results for 27 available PKC theta Elisa Kits ranked by validation data
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- GeneTex PRKCQ antibody for PRKCQ
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- ViGene Biosciences adenoviral particle packaged cDNA for PRKCQ gene
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- Search ViGene Biosciences for PRKCQ
- Santa Cruz Biotechnology (SCBT) Antibodies for PRKCQ
- Search Santa Cruz Biotechnology (SCBT) for PRKCQ siRNA/shRNA
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