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PRKCQ Gene

protein-coding   GIFtS: 73
GCID: GC10M006509

Protein Kinase C, Theta

  See PRKCQ-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Theta1 2
PRKCT2 3
nPKC-theta2 3
EC 2.7.11.133 8
Protein Kinase C Theta Type2
EC 2.7.118

External Ids:    HGNC: 94101   Entrez Gene: 55882   Ensembl: ENSG000000656757   OMIM: 6004485   UniProtKB: Q047593   

Export aliases for PRKCQ gene to outside databases

Previous GC identifers: GC10M006413 GC10M006619 GC10M006473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCQ Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC
family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important
for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may
link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PRKCQ Gene:
PRKCQ (protein kinase C, theta) is a protein-coding gene. Diseases associated with PRKCQ include gastrointestinal stromal tumor. GO annotations related to this gene include ubiquitin-protein ligase activity and identical protein binding. An important paralog of this gene is PRKCH.

UniProtKB/Swiss-Prot: KPCT_HUMAN, Q04759
Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation,
proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as
NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of
NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent
NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct
phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and
recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and
activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2)
pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and
may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2
transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and
intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is
required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of
TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells
following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is
necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR
stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from
BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In
platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors,
playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals
from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the
regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory
effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine
phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of
phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively
regulates its ability to phosphorylate PKB/AKT1

summary for PRKCQ Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCQ gene promoter:
         GR   AML1a   FOXF2   Pbx1a   Nkx2-2   GR-beta   Nkx2-5   Nkx5-1   HNF-4alpha1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCQ promoter sequence
   Search Chromatin IP Primers for PRKCQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p15

PRKCQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCQ gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M006509:  view genomic region     (about GC identifiers)

Start:
6,469,105 bp from pter      End:
6,622,263 bp from pter
Size:
153,159 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KPCT_HUMAN, Q04759 (See protein sequence)
Recommended Name: Protein kinase C theta type  
Size: 706 amino acids; 81865 Da
Cofactor: Magnesium
Subunit: Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at
least of BCL10, CARD11, MALT1 and IKBKB
5 PDB 3D structures from and Proteopedia for PRKCQ:
1XJD (3D)        2ENJ (3D)        2ENN (3D)        2ENZ (3D)        2JED (3D)    
Secondary accessions: Q14DH6 Q3MJF1 Q64FY5 Q9H508 Q9H549
Alternative splicing: 2 isoforms:  Q04759-1   Q04759-2   

Explore the universe of human proteins at neXtProt for PRKCQ: NX_Q04759

Explore proteomics data for PRKCQ at MOPED

Post-translational modifications: 

  • Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen
    receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-6851
  • Ubiquitination2 at Lys77, Lys110, Lys286, Lys325, Lys384, Lys527
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCQ (Q04759) (see all 22)
     GVLLYEM  DFGMCKE  YIAPEIL  GQSPFHG 


    See PRKCQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229342.1  NP_001269573.1  NP_001269574.1  NP_006248.1  

    ENSEMBL proteins: 
     ENSP00000263125   ENSP00000380361   ENSP00000441752  
    Reactome Protein details: Q04759

    PRKCQ Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCQ Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCQ
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRKCQ
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRKCQ
    GenScript Custom Purified and Recombinant Proteins Services for PRKCQ
    Novus Biologicals PRKCQ Proteins
    Novus Biologicals PRKCQ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCQ 

     
    antibodies-online proteins for PRKCQ (10 products) 

     
    antibodies-online peptides for PRKCQ

    PRKCQ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCQ
    R&D Systems Antibodies for PRKCQ (PKC theta)
    Cell Signaling Technology (CST) Antibodies for PRKCQ  (PKCT)
    OriGene Antibodies for PRKCQ
    OriGene Custom Antibody Services for PRKCQ
    Novus Biologicals PRKCQ Antibodies
    Abcam antibodies for PRKCQ (Q05655, Q04759)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PRKCQ
    antibodies-online antibodies for PRKCQ (188 products) 

    PRKCQ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCQ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCQ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKCQ 
    antibodies-online kits for PRKCQ (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, theta
    Delta subfamily
    Protein kinase C

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR014376 Prot_kin_PKC_delta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q04759

    ProtoNet protein and cluster: Q04759

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCT_HUMAN, Q04759
    Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol
    sensor and the C2 domain is a non-calcium binding domain
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCQ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCT_HUMAN, Q04759
    Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
    that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation,
    proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as
    NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of
    NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent
    NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct
    phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and
    recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and
    activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2)
    pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and
    may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2
    transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and
    intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is
    required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of
    TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells
    following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is
    necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR
    stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from
    BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In
    platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors,
    playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals
    from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the
    regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory
    effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine
    phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of
    phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively
    regulates its ability to phosphorylate PKB/AKT1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by
    diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase
    domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation

         Genatlas biochemistry entry for PRKCQ:
    protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T
    lymphocytes

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004842ubiquitin-protein ligase activity TAS--
         
    Find genes that share ontologies with PRKCQ           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for PRKCQ:
     Decreased substrate adherent c  Decreased telomerase activity  Decreased viability  Gemcitabine induced cell-death 
     Increased apoptosis  Increased cell death in breast  Increased viability with TRAIL  Synthetic lethal with imatinib 
     Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkcq):
     adipose tissue  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  respiratory system  tumorigenesis 

    Find genes that share phenotypes with PRKCQ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKCQ: Prkcqtm1Litt Prkcqtm1.1Bai

       genOway: Develop your customized and physiologically relevant rodent model for PRKCQ

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PRKCQ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCQ (see all 11):
    hsa-miR-3659 hsa-miR-224 hsa-miR-3606 hsa-miR-526b hsa-miR-578 hsa-miR-513c hsa-miR-1297 hsa-miR-921
    SwitchGear 3'UTR luciferase reporter plasmidPRKCQ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKCQ
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCQ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCQ

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCQ (see all 7)
    OriGene ORF clones in mouse, rat for PRKCQ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCQ (NM_006257)
    Sino Biological Human cDNA Clone for PRKCQ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCQ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCQ
    Addgene plasmids for PRKCQ 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCQ

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12073) for PRKCQ 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCT_HUMAN, Q04759: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly
    localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the
    immunological synapse
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with PRKCQ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCQ About   (see all 90)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    3ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    4G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    5B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36


    Find genes that share SuperPaths with PRKCQ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PRKCQ
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCQ (see all 79)
        UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    NF-kappaB Activation by Viruses

    2 Cell Signaling Technology (CST) Pathways for PRKCQ
        Ca, cAMP and Lipid Signaling
    Lymphocyte Signaling

    2 Tocris Bioscience Pathways for PRKCQ
        NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCQ (see all 18)
        Signal transduction cAMP signaling
    Development EGFR signaling pathway
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for PRKCQ (see all 18)
        Myometrial Relaxation and Contraction Pathways
    Wnt Signaling Pathway
    Insulin Signaling
    Wnt Signaling Pathway and Pluripotency
    G Protein Signaling Pathways


    Selected Reactome Pathways for PRKCQ (see all 7)
        Effects of PIP2 hydrolysis
    Netrin-1 signaling
    Downstream TCR signaling
    FCERI mediated NF-kB activation
    Apoptotic cleavage of cellular proteins

    2 PharmGKB Pathways for PRKCQ
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCQ) (see all 7):
        NF-kappa B signaling pathway
    Vascular smooth muscle contraction
    Tight junction
    T cell receptor signaling pathway
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCQ: 
              Alzheimer's Disease in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCQ (Q047591, 2, 3 ENSP000002631254) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062391, 3, ENSP000003378254EBI-374762,EBI-1348 I2D: score=3 STRING: ENSP00000337825
    MARK3P274482, 3, ENSP000004113974MINT-4787821 I2D: score=3 STRING: ENSP00000411397
    BCL10O959992, 3MINT-4787836 I2D: score=3 
    BTKQ061871, 3, ENSP000003081764EBI-374762,EBI-624835 I2D: score=3 STRING: ENSP00000308176
    GLRX3O760031, 3, ENSP000003308364EBI-374762,EBI-374781 I2D: score=4 STRING: ENSP00000330836
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS8444877
    GO:0006355regulation of transcription, DNA-templated ISS--
    GO:0006468protein phosphorylation ----
    GO:0006509membrane protein ectodomain proteolysis ISS--
    GO:0006915apoptotic process TAS--

    Find genes that share ontologies with PRKCQ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    10 ApexBio Compounds for PRKCQ     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCQ (see all 847)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    3 DrugBank Compounds for PRKCQ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonoserine-- --target--17139284 17016423
    Phosphonothreonine-- --target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for PRKCQ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43.5 1 19966856 (1)
    serine 34.1 2 14704736 (1), 19966856 (1), 17567459 (1)
    phosphatidylinositol 28.7 1 18227156 (1)
    lipid 16.6 6 14673152 (1), 12234921 (1), 15699116 (1), 11120819 (1) (see all 6)
    calcium 0 6 17825894 (2), 15912140 (1), 15699116 (1)



    Find genes that share compounds with PRKCQ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKCQ gene (4 alternative transcripts): 
    NM_001242413.2  NM_001282644.1  NM_001282645.1  NM_006257.4  

    Unigene Cluster for PRKCQ:

    Protein kinase C, theta
    Hs.498570  [show with all ESTs]
    Unigene Representative Sequence: BX647657
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263125(uc001iji.1 uc001ijj.2 uc009xim.2 uc009xin.2 uc010qax.2)
    ENST00000397176 ENST00000539722
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    Additional mRNA sequence: 

    AK293935.1 AK308099.1 AK312411.1 AY702977.1 BC101465.1 BC113359.1 BC143222.1 BX647657.1 
    L01087.1 L07032.1 

    5 DOTS entries:

    DT.455113  DT.100670612  DT.121297809  DT.121297788  DT.75144546 

    Selected AceView cDNA sequences (see all 43):

    AW593784 AA384107 AW780437 BF592799 NM_006257 AI184050 BE501078 AU099414 
    AA234440 BX646952 T28732 W72149 AI075190 R16950 BX437722 AI284161 
    L07032 F24815 L01087 AW950791 W77909 AY702977 BX647657 AI282639 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCQ    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                 -                                                                                                   
    SP2:                                -                                                                                                   
    SP3:              -                                                                                                                     


    ECgene alternative splicing isoforms for PRKCQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKCQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAACAGGT
    PRKCQ Expression
    About this image


    PRKCQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Oligodendrocyte-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)
             Spinal Dorsal Columns
    PRKCQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCQ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498570

    UniProtKB/Swiss-Prot: KPCT_HUMAN, Q04759
    Tissue specificity: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCQ gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcq1 , 5 protein kinase C, theta1, 5 87.33(n)1
    94.89(a)1
      2 (8.42 cM)5
    187611  NM_008859.21  NP_032885.11 
     111721135 
    chicken
    (Gallus gallus)
    Aves PRKCQ1 protein kinase C, theta 77.32(n)
    83.1(a)
      776459  XM_001235979.3  XP_001235980.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCQ6
    protein kinase C, theta
    68(a)
    1 ↔ 1
    5(482253-516161)
    zebrafish
    (Danio rerio)
    Actinopterygii prkcq1 protein kinase C, theta 69.98(n)
    75.18(a)
      555521  NM_001089370.2  NP_001082839.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk17E3 protein amino acid phosphorylation
    protein serine/threonine more
    33(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tpa-13 protein kinase C 47(a)   IV(92052-110151)   --


    ENSEMBL Gene Tree for PRKCQ (if available)
    TreeFam Gene Tree for PRKCQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCQ gene
    PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCQ using alignment to 2 protein entries:     KPCT_HUMAN (see all proteins) (see all similar genes):
    PRKCD    PRKD1    MARK4    PRKCH    AKT1    KIN27
    RPS6KB1    PRKACB    PRKCE    NUAK1    STK32A    PRKACG
    SGK2    RPS6KA2    AKT2    PKN1    PRKACA    RPS6KA1

    Find genes that share paralogs with PRKCQ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCQ (see all 3498)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423194
    A colorectal adenocarcinoma sample4--see VAR_0423192 K N mis40--------
    rs1424375731,2
    Cuntested16553150(+) TCTGCC/TCGTTC 4 E G mis11Minor allele frequency- T:0.00NA 4550
    rs8063991,2
    C,F,O,A,H--6468605(+) GCTCCG/ATATAG 2 -- int129Minor allele frequency- A:0.17NS EA NA WA CSA 3222
    rs47504381,2
    C,F,A--6468622(+) AAATGT/CTCCAG 2 -- int17Minor allele frequency- C:0.44NA CSA WA EA 366
    rs79100231,2
    C,F--6468630(+) CAGCAC/TACCTG 2 -- int16Minor allele frequency- T:0.16WA NA EA 364
    rs770799881,2
    --6468706(+) AGCCAC/TGTGAT 2 -- int10--------
    rs118149141,2
    C,F,H--6468710(+) ATGTGA/TTGAGG 2 -- int18Minor allele frequency- T:0.07NS EA NA WA 546
    rs6487311,2
    C,F,O,A,H--6468731(+) ACTCCG/AAATAT 2 -- int128Minor allele frequency- A:0.17NS EA NA WA CSA 2780
    rs1861439641,2
    --6468807(+) CTACTC/TCTGCC 2 -- int10--------
    rs122483581,2
    C,F--6468843(+) taggcT/Ccccgc 2 -- int12Minor allele frequency- C:0.33CSA 3

    HapMap Linkage Disequilibrium report for PRKCQ (6469105 - 6622263 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRKCQ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5698CNV Insertion18451855
    nsv507533CNV Insertion20534489
    nsv515823CNV Loss19592680
    nsv5687CNV Loss18451855
    nsv7198OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCQ
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600448    OMIM disorders: --

    1 disease for PRKCQ:    
    About MalaCards
    gastrointestinal stromal tumor


    Find genes that share disorders with PRKCQ           About GenesLikeMe

    6 Novoseek inferred disease relationships for PRKCQ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 61 3 18521081 (1), 15217944 (1), 15289315 (1)
    leukemia t-cell 45.1 2 12188914 (1), 11274147 (1)
    leukemia 1.78 1 10222061 (1)
    inflammation 0 1 14704736 (1)
    tumors 0 4 18521081 (1), 20096441 (1), 15217944 (1)
    sarcoma 0 1 15217944 (1)

    Genetic Association Database (GAD): PRKCQ
    Human Genome Epidemiology (HuGE) Navigator: PRKCQ (27 documents)

    Export disorders for PRKCQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCQ gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with PRKCQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PubMed id 8444877)1, 2, 3 Baier G.... Altman A. (J. Biol. Chem. 1993)
    2. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). (PubMed id 15364919)1, 2, 9 Li Y.... Polakiewicz R.D. (J. Biol. Chem. 2004)
    3. Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. (PubMed id 11772397)1, 2, 9 Liu Y.... Shaw S. (Biochem. J. 2002)
    4. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. (PubMed id 11342610)1, 2, 9 Villalba M.... Altman A. (J. Immunol. 2001)
    5. Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. (PubMed id 10652356)1, 2, 9 Liu Y.... Altman A. (J. Biol. Chem. 2000)
    6. Protein kinase C-theta in platelet activation. (PubMed id 21944869)1, 2 Cohen S.... Isakov N. (FEBS Lett. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PubMed id 19674979)1, 4 Hinks A....Thomson W. (Ann. Rheum. Dis. 2010)
    9. A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. (PubMed id 20049410)1, 4 Wieczorek S....Epplen J.T. (J. Mol. Med. 2010)
    10. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. (PubMed id 20498205)1, 4 Plant D....Worthington J. (Ann. Rheum. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5588 HGNC: 9410 AceView: PRKCQ Ensembl:ENSG00000065675 euGenes: HUgn5588
    ECgene: PRKCQ Kegg: 5588 H-InvDB: PRKCQ

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCQ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCQ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKCQ gene:
    Search GeneIP for patents involving PRKCQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     antibodies-online proteins for PRKCQ (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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