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Aliases for PRKCQ Gene

Aliases for PRKCQ Gene

  • Protein Kinase C, Theta 2 3
  • EC 2.7.11.13 4 63
  • NPKC-Theta 3 4
  • PRKCT 3 4
  • Protein Kinase C Theta Type 3
  • EC 2.7.11 63

External Ids for PRKCQ Gene

Previous GeneCards Identifiers for PRKCQ Gene

  • GC10M006413
  • GC10M006619
  • GC10M006509

Summaries for PRKCQ Gene

Entrez Gene Summary for PRKCQ Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCQ Gene

PRKCQ (Protein Kinase C, Theta) is a Protein Coding gene. Diseases associated with PRKCQ include gastrointestinal stromal tumor. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCQ Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Tocris Summary for PRKCQ Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCQ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCQ Gene

Genomics for PRKCQ Gene

Regulatory Elements for PRKCQ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKCQ Gene

Start:
6,393,596 bp from pter
End:
6,580,301 bp from pter
Size:
186,706 bases
Orientation:
Minus strand

Genomic View for PRKCQ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCQ Gene

Proteins for PRKCQ Gene

  • Protein details for PRKCQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04759-KPCT_HUMAN
    Recommended name:
    Protein kinase C theta type
    Protein Accession:
    Q04759
    Secondary Accessions:
    • B4DF52
    • Q14DH6
    • Q3MJF1
    • Q64FY5
    • Q9H508
    • Q9H549

    Protein attributes for PRKCQ Gene

    Size:
    706 amino acids
    Molecular mass:
    81865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB.

    Three dimensional structures from OCA and Proteopedia for PRKCQ Gene

    Alternative splice isoforms for PRKCQ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCQ Gene

Proteomics data for PRKCQ Gene at MOPED

Post-translational modifications for PRKCQ Gene

  • Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.
  • Ubiquitination at Lys77, Lys110, Lys286, Lys325, Lys384, and Lys527
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCQ Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCQ (PKCT)

Domains for PRKCQ Gene

Graphical View of Domain Structure for InterPro Entry

Q04759

UniProtKB/Swiss-Prot:

KPCT_HUMAN :
  • Q04759
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCQ: view

Function for PRKCQ Gene

Molecular function for PRKCQ Gene

GENATLAS Biochemistry:
protein kinase C,theta polypeptide,critically involved in the regulation of differentiation and proliferation of T lymphocytes
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.

Enzyme Numbers (IUBMB) for PRKCQ Gene

Gene Ontology (GO) - Molecular Function for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with PRKCQ: view
genes like me logo Genes that share phenotypes with PRKCQ: view

Animal Models for PRKCQ Gene

MGI Knock Outs for PRKCQ:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKCQ

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PRKCQ Gene

Localization for PRKCQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCQ Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCQ Gene COMPARTMENTS Subcellular localization image for PRKCQ gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PRKCQ: view

Pathways for PRKCQ Gene

genes like me logo Genes that share pathways with PRKCQ: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRKCQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8444877
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006468 protein phosphorylation IEA --
GO:0006509 membrane protein ectodomain proteolysis ISS --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with PRKCQ: view

Compounds for PRKCQ Gene

(5) Tocris Compounds for PRKCQ Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(847) HMDB Compounds for PRKCQ Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(3) Drugbank Compounds for PRKCQ Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphonoserine
target
Phosphonothreonine
target
Staurosporine
62996-74-1 target

(5) Novoseek inferred chemical compound relationships for PRKCQ Gene

Compound -log(P) Hits PubMed IDs
tyrosine 43.5 1
serine 34.1 3
phosphatidylinositol 28.7 1
lipid 16.6 6
calcium 0 4
genes like me logo Genes that share compounds with PRKCQ: view

Transcripts for PRKCQ Gene

Unigene Clusters for PRKCQ Gene

Protein kinase C, theta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKCQ

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCQ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PRKCQ Gene

GeneLoc Exon Structure for
PRKCQ
ECgene alternative splicing isoforms for
PRKCQ

Expression for PRKCQ Gene

mRNA expression in normal human tissues for PRKCQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCQ Gene

This gene is overexpressed in Muscle - Skeletal (18.3) and Whole Blood (4.7).

Protein differential expression in normal tissues for PRKCQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.7) and Heart (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCQ Gene

SOURCE GeneReport for Unigene cluster for PRKCQ Gene Hs.498570

mRNA Expression by UniProt/SwissProt for PRKCQ Gene

Q04759-KPCT_HUMAN
Tissue specificity: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.
genes like me logo Genes that share expressions with PRKCQ: view

Expression partners for PRKCQ Gene

In Situ Assay Products

Orthologs for PRKCQ Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCQ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKCQ 35
  • 89.19 (n)
  • 96.18 (a)
PRKCQ 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCQ 35
  • 90.84 (n)
  • 96.74 (a)
PRKCQ 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcq 35
  • 87.33 (n)
  • 94.89 (a)
Prkcq 16
Prkcq 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCQ 35
  • 99.58 (n)
  • 99.72 (a)
PRKCQ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcq 35
  • 87.57 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCQ 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCQ 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCQ 35
  • 77.32 (n)
  • 83.1 (a)
PRKCQ 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCQ 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prkcq 35
  • 69.98 (n)
  • 75.18 (a)
prkcq 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 33 (a)
Pkcdelta 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tpa-1 37
  • 47 (a)
tpa-1 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for PRKCQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKCQ Gene

ENSEMBL:
Gene Tree for PRKCQ (if available)
TreeFam:
Gene Tree for PRKCQ (if available)

Paralogs for PRKCQ Gene

Paralogs for PRKCQ Gene

genes like me logo Genes that share paralogs with PRKCQ: view

Variants for PRKCQ Gene

Sequence variations from dbSNP and Humsavar for PRKCQ Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2453 -- 6,427,711(-) GATGT(A/G)TAAAT utr-variant-3-prime, intron-variant
rs472317 -- 6,490,216(+) CTAAC(C/T)CCTCC intron-variant
rs475843 -- 6,477,444(+) GGTGG(G/T)GATGG intron-variant
rs477840 -- 6,484,267(+) GAATT(A/C)GCTGG intron-variant
rs480992 -- 6,511,672(+) GAACT(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCQ Gene

Variant ID Type Subtype PubMed ID
nsv7198 OTHER Inversion 18451855
nsv5687 CNV Loss 18451855
nsv507533 CNV Insertion 20534489
nsv515823 CNV Loss 19592680
nsv5698 CNV Insertion 18451855

Relevant External Links for PRKCQ Gene

HapMap Linkage Disequilibrium report
PRKCQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCQ Gene

Disorders for PRKCQ Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PRKCQ Gene in MalaCards »

(1) Diseases for PRKCQ Gene including...

(6) Novoseek inferred disease relationships for PRKCQ Gene

Disease -log(P) Hits PubMed IDs
gastrointestinal stromal tumor 61 3
leukemia t-cell 45.1 2
leukemia 1.78 1
inflammation 0 1
tumors 0 3

Relevant External Links for PRKCQ

Genetic Association Database (GAD)
PRKCQ
Human Genome Epidemiology (HuGE) Navigator
PRKCQ
genes like me logo Genes that share disorders with PRKCQ: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PRKCQ Gene

Publications for PRKCQ Gene

  1. Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. (PMID: 10652356) Liu Y. … Altman A. (J. Biol. Chem. 2000) 3 4 23
  2. Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. (PMID: 11772397) Liu Y. … Shaw S. (Biochem. J. 2002) 3 4 23
  3. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. (PMID: 11342610) Villalba M. … Altman A. (J. Immunol. 2001) 3 4 23
  4. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). (PMID: 15364919) Li Y. … Polakiewicz R.D. (J. Biol. Chem. 2004) 3 4 23
  5. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. (PMID: 8444877) Baier G. … Altman A. (J. Biol. Chem. 1993) 2 3 4

Products for PRKCQ Gene

  • Addgene plasmids for PRKCQ

Sources for PRKCQ Gene

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