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Aliases for PRKCI Gene

Aliases for PRKCI Gene

  • Protein Kinase C, Iota 2 3
  • Atypical Protein Kinase C-Lambda/Iota 3 4
  • PRKC-Lambda/Iota 3 4
  • APKC-Lambda/Iota 3 4
  • EC 2.7.11.13 4 63
  • NPKC-Iota 3 4
  • DXS1179E 3 4
  • Protein Kinase C Iota Type 3
  • EC 2.7.11 63
  • PKCI 3

External Ids for PRKCI Gene

Previous Symbols for PRKCI Gene

  • DXS1179E

Summaries for PRKCI Gene

Entrez Gene Summary for PRKCI Gene

  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCI Gene

PRKCI (Protein Kinase C, Iota) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Ras signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCI Gene

  • Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Tocris Summary for PRKCI Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCI Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCI Gene

Genomics for PRKCI Gene

Genomic Location for PRKCI Gene

Start:
170,222,365 bp from pter
End:
170,305,982 bp from pter
Size:
83,618 bases
Orientation:
Plus strand

Genomic View for PRKCI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCI Gene

Regulatory Elements for PRKCI Gene

Proteins for PRKCI Gene

  • Protein details for PRKCI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41743-KPCI_HUMAN
    Recommended name:
    Protein kinase C iota type
    Protein Accession:
    P41743
    Secondary Accessions:
    • D3DNQ4
    • Q8WW06

    Protein attributes for PRKCI Gene

    Size:
    596 amino acids
    Molecular mass:
    68262 Da
    Quaternary structure:
    • Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 (Thr-359 phosphorylated form).
    SequenceCaution:
    • Sequence=AAA60171.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB17011.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22016.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKCI Gene

neXtProt entry for PRKCI Gene

Proteomics data for PRKCI Gene at MOPED

Post-translational modifications for PRKCI Gene

  • Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334. Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKCI Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRKCI Gene

Suggested Antigen Peptide Sequences for PRKCI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41743

UniProtKB/Swiss-Prot:

KPCI_HUMAN
Domain:
  • The PB1 domain mediates interaction with SQSTM1.:
    • P41743
  • The C1 zinc finger does not bind diacylglycerol (DAG):
    • P41743
  • The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except the presence of a non-phosphorylatable residue in place of Ser, it modulates activity by competing with substrates.:
    • P41743
  • Contains 1 AGC-kinase C-terminal domain.:
    • P41743
  • Contains 1 PB1 domain.:
    • P41743
  • Contains 1 protein kinase domain.:
    • P41743
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.:
    • P41743
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.:
    • P41743
genes like me logo Genes that share domains with PRKCI: view

Function for PRKCI Gene

Molecular function for PRKCI Gene

GENATLAS Biochemistry: protein kinase C,iota polypeptide
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=13.5 uM for ATP (for recombinant purified PRKCI) {ECO:0000269 PubMed:10906326}; Vmax=7.4 pmol/min/mg enzyme {ECO:0000269 PubMed:10906326};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-412 (activation loop of the kinase domain) and Thr-564 (turn motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion.
UniProtKB/Swiss-Prot Function: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Enzyme Numbers (IUBMB) for PRKCI Gene

Gene Ontology (GO) - Molecular Function for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11724794
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11257119
genes like me logo Genes that share ontologies with PRKCI: view
genes like me logo Genes that share phenotypes with PRKCI: view

Animal Models for PRKCI Gene

MGI Knock Outs for PRKCI:

miRNA for PRKCI Gene

miRTarBase miRNAs that target PRKCI

No data available for Transcription Factor Targeting and HOMER Transcription for PRKCI Gene

Localization for PRKCI Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCI Gene

Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCI Gene COMPARTMENTS Subcellular localization image for PRKCI gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
plasma membrane 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA 11260256
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKCI: view

Pathways for PRKCI Gene

genes like me logo Genes that share pathways with PRKCI: view

Gene Ontology (GO) - Biological Process for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 8226978
GO:0006612 protein targeting to membrane NAS 11257119
GO:0007010 cytoskeleton organization NAS 11257119
GO:0007015 actin filament organization IEA --
GO:0010976 positive regulation of neuron projection development IMP 10467349
genes like me logo Genes that share ontologies with PRKCI: view

Compounds for PRKCI Gene

(10) ApexBio Compounds for PRKCI Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(5) Tocris Compounds for PRKCI Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(846) HMDB Compounds for PRKCI Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(1) Drugbank Compounds for PRKCI Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Rbt205 Inhibitor
target

(1) Novoseek inferred chemical compound relationships for PRKCI Gene

Compound -log(P) Hits PubMed IDs
gf 109203x 52.5 1
genes like me logo Genes that share compounds with PRKCI: view

Transcripts for PRKCI Gene

Unigene Clusters for PRKCI Gene

Protein kinase C, iota:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCI Gene

No ASD Table

Relevant External Links for PRKCI Gene

GeneLoc Exon Structure for
PRKCI
ECgene alternative splicing isoforms for
PRKCI

Expression for PRKCI Gene

mRNA expression in normal human tissues for PRKCI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCI Gene

SOURCE GeneReport for Unigene cluster for PRKCI Gene Hs.478199

mRNA Expression by UniProt/SwissProt for PRKCI Gene

P41743-KPCI_HUMAN
Tissue specificity: Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.
genes like me logo Genes that share expressions with PRKCI: view

No data available for mRNA differential expression in normal tissues for PRKCI Gene

Orthologs for PRKCI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCI 35
  • 99.89 (n)
  • 100 (a)
PRKCI 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCI 35
  • 94.46 (n)
  • 99.16 (a)
PRKCI 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCI 35
  • 94.74 (n)
  • 98.49 (a)
PRKCI 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkci 35
  • 90.64 (n)
  • 98.49 (a)
Prkci 16
Prkci 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCI 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCI 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkci 35
  • 89.99 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves PRKCI 35
  • 83.93 (n)
  • 95.07 (a)
PRKCI 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCI 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.967 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prkci 35
  • 80.27 (n)
  • 92.84 (a)
Str.15038 35
zebrafish
(Danio rerio)
Actinopterygii prkci 35
  • 76.08 (n)
  • 89.63 (a)
prkci 36
  • 89 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aPKC 35
  • 63.16 (n)
  • 69.83 (a)
aPKC 36
  • 39 (a)
OneToMany
aPKC 37
  • 67 (a)
Pk17E 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 35
  • 60.53 (n)
  • 60.71 (a)
pkc-3 36
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for PRKCI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCI Gene

ENSEMBL:
Gene Tree for PRKCI (if available)
TreeFam:
Gene Tree for PRKCI (if available)

Paralogs for PRKCI Gene

Paralogs for PRKCI Gene

Pseudogenes.org Pseudogenes for PRKCI Gene

genes like me logo Genes that share paralogs with PRKCI: view

Variants for PRKCI Gene

Sequence variations from dbSNP and Humsavar for PRKCI Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs481781 -- 170,222,257(+) CCCTC(C/T)CGGCG upstream-variant-2KB
rs511258 -- 170,248,934(-) GGAGG(C/T)GGAGC intron-variant
rs511300 -- 170,248,916(-) GAACT(C/G)AGATC intron-variant
rs511377 -- 170,248,887(-) CTGGG(C/T)GACAA intron-variant
rs516741 -- 170,248,312(-) GAAAG(A/C)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCI Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv820125 CNV Loss 19587683
nsv821366 CNV Duplication 20802225
esv32986 CNV Gain 17666407
esv268960 CNV Insertion 20981092
esv273479 CNV Insertion 20981092
esv1665880 CNV Insertion 17803354
nsv4112 CNV Loss 18451855

Relevant External Links for PRKCI Gene

HapMap Linkage Disequilibrium report
PRKCI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCI Gene

Disorders for PRKCI Gene

(4) Novoseek inferred disease relationships for PRKCI Gene

Disease -log(P) Hits PubMed IDs
cancer lung 36.9 3
tumors 34.1 4
hepatocellular carcinoma 20.4 1
cancer 16.5 2

Relevant External Links for PRKCI

Human Genome Epidemiology (HuGE) Navigator
PRKCI
genes like me logo Genes that share disorders with PRKCI: view

No data available for UniProtKB/Swiss-Prot for PRKCI Gene

Publications for PRKCI Gene

  1. Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. (PMID: 7607695) Mazzarella R. … D'Esposito M. (Genomics 1995) 2 3 4 23
  2. Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. (PMID: 9346882) Murray N.R. … Fields A.P. (J. Biol. Chem. 1997) 3 4 23
  3. Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. (PMID: 14684752) Mamidipudi V. … Wooten M.W. (J. Biol. Chem. 2004) 3 4 23
  4. Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC- iota in human glioma cells. (PMID: 15695176) Bicaku E. … Acevedo-Duncan M. (Tissue Cell 2005) 3 4 23
  5. Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. (PMID: 16125198) Messerschmidt A. … Blaesse M. (J. Mol. Biol. 2005) 3 4 23

Products for PRKCI Gene

  • Addgene plasmids for PRKCI

Sources for PRKCI Gene

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