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PRKCI Gene

protein-coding   GIFtS: 71
GCID: GC03P169940

Protein Kinase C, Iota


(Previous symbol: DXS1179E)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Iota1 2     nPKC-iota2 3
DXS1179E1 2 3     EC 2.7.11.133 8
Atypical Protein Kinase C-Lambda/Iota2 3     PKCI2
PRKC-lambda/iota2 3     Protein Kinase C Iota Type2
aPKC-lambda/iota2 3     EC 2.7.118

External Ids:    HGNC: 94041   Entrez Gene: 55842   Ensembl: ENSG000001635587   OMIM: 6005395   UniProtKB: P417433   

Export aliases for PRKCI gene to outside databases

Previous GC identifers: GC0XM096083 GC03P170989 GC03P171342 GC03P171261 GC03P171422 GC03P167310


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCI Gene:
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC
family comprises at least eight members, which are differentially expressed and are involved in a wide variety of
cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by
phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct
interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase
(GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be
necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against
drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCI Gene:
PRKCI (protein kinase C, iota) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCI_HUMAN, P41743
Function: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective
role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and
polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary
for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against
drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell
death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol
3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic
factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and
regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In
response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the
subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical
domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of
EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and
PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the
early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters
(VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates
lipid-induced apoptosis

summary for PRKCI Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCI gene promoter:
         NF-1   NF-1/L   NF-AT   AREB6   NF-AT4   Pax-3   NF-AT2   FOXO4   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCI promoter sequence
   Search Chromatin IP Primers for PRKCI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.3

PRKCI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCI gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P169940:  view genomic region     (about GC identifiers)

Start:
169,940,153 bp from pter      End:
170,023,770 bp from pter
Size:
83,618 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KPCI_HUMAN, P41743 (See protein sequence)
Recommended Name: Protein kinase C iota type  
Size: 596 amino acids; 68262 Da
Subunit: Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable).
Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC,
PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with
LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the
kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the
membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 ('Thr-359' phosphorylated form)
Sequence caution: Sequence=AAA60171.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAB17011.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH22016.3;
Type=Erroneous initiation; Note=Translation N-terminally extended;
6 PDB 3D structures from and Proteopedia for PRKCI:
1VD2 (3D)        1WMH (3D)        1ZRZ (3D)        3A8W (3D)        3A8X (3D)        3ZH8 (3D)    
Secondary accessions: D3DNQ4 Q8WW06

Explore the universe of human proteins at neXtProt for PRKCI: NX_P41743

Explore proteomics data for PRKCI at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal
    growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334. Phosphorylation at
    Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on
    Tyr-334 is important for NF-kappa-B stimulation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCI (P41743) (see all 29)
     LHSCFQT  GHIKLTD  VNGGDLM  YIAPEIL 


    See PRKCI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002731.4  
    ENSEMBL proteins: 
     ENSP00000295797  
    Reactome Protein details: P41743

    PRKCI Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCI Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCI
    OriGene Purified Protein for PRKCI
    OriGene Protein Over-expression Lysate for PRKCI
    OriGene MassSpec for PRKCI
    OriGene Custom Protein Services for PRKCI
    GenScript Custom Purified and Recombinant Proteins Services for PRKCI
    Novus Biologicals PRKCI Proteins
    Novus Biologicals PRKCI Lysate
    Sino Biological Recombinant Protein for PRKCI
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCI 

     
    antibodies-online proteins for PRKCI (9 products) 

     
    antibodies-online peptides for PRKCI

    PRKCI Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PRKCI  (PKCI)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRKCI
    Novus Biologicals PRKCI Antibodies
    Abcam antibodies for PRKCI
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PRKCI
    antibodies-online antibodies for PRKCI (36 products) 

    PRKCI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCI
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKCI 
    antibodies-online kits for PRKCI (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, iota
    Iota subfamily
    Protein kinase C

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR012233 PKC_zeta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P41743

    ProtoNet protein and cluster: P41743

    3 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCI_HUMAN, P41743
    Domain: The OPR domain mediates interaction with SQSTM1 (By similarity)
    Domain: The C1 zinc finger does not bind diacylglycerol (DAG)
    Domain: The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except
    the presence of a non-phosphorylatable residue in place of Ser, it modulates activity by competing with
    substrates (By similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCI_HUMAN, P41743
    Function: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective
    role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and
    polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary
    for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against
    drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell
    death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol
    3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic
    factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and
    regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In
    response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the
    subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical
    domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of
    EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and
    PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the
    early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters
    (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates
    lipid-induced apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due
    to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol
    esters or calcium ions. Two specific sites, Thr-412 (activation loop of the kinase domain) and Thr-564 (turn
    motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid
    activators that are elevated during nutrient-stimulated insulin secretion
    Biophysicochemical properties: Kinetic parameters: KM=13.5 uM for ATP (for recombinant purified PRKCI); Vmax=7.4
    pmol/min/mg enzyme;

         Genatlas biochemistry entry for PRKCI:
    protein kinase C,iota polypeptide

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA11724794
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004697protein kinase C activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11257119
         
    Find genes that share ontologies with PRKCI           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKCI:
     Gemcitabine induced cell-death  Increased circadian period len 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Prkci) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  nervous system  pigmentation  renal/urinary system 

    Find genes that share phenotypes with PRKCI           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKCI: Prkcitm1Hed Prkcitm1.1Rfar Prkcitm1.1Kido Prkcitm1Ltg

       genOway: Develop your customized and physiologically relevant rodent model for PRKCI

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKCI:
    hsa-mir-155-5p (MIRT001515), hsa-mir-93-5p (MIRT048786), hsa-mir-505-5p (MIRT037939)

    Block miRNA regulation of human, mouse, rat PRKCI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCI (see all 21):
    hsa-miR-548j hsa-miR-548i hsa-miR-376b hsa-miR-219-5p hsa-miR-3613-3p hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidPRKCI 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRKCI
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCI

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCI (see all 9)
    OriGene ORF clones in mouse, rat for PRKCI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCI (NM_002740)
    Sino Biological Human cDNA Clone for PRKCI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCI
    Addgene plasmids for PRKCI 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCI

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12239) for PRKCI 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCI_HUMAN, P41743: Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through
    interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with
    KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs)
    through interaction with RAB2A
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    nucleus5
    plasma membrane4
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000133polarisome TAS14676191
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA11260256
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--

    Find genes that share ontologies with PRKCI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCI About   (see all 71)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    3VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    4ErbB4 Pathway
    ErbB4 Pathway0.59
    LPS Stimulated MAPK Signaling0.47
    ErbB Family Pathway0.59
    UVC-Induced MAPK Signaling0.44
    Prolactin Signaling0.54
    FGF Pathway0.37
    Growth Hormone Signaling0.49
    PACAP Signaling0.37
    5Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37


    Find genes that share SuperPaths with PRKCI           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PRKCI
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCI (see all 68)
        UVB-Induced MAPK Signaling
    Intracellular Calcium Signaling
    NF-kappaB Activation by Viruses
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCI
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCI
        NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCI (see all 8)
        Signal transduction Erk Interactions- Inhibition of Erk
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction cAMP signaling
    Transcription Transcription factor Tubby signaling pathways

    Selected BioSystems Pathways for PRKCI (see all 14)
        EGFR1 Signaling Pathway
    Wnt Signaling Pathway
    Insulin Signaling
    Wnt Signaling Pathway and Pluripotency
    G Protein Signaling Pathways

    5 Sino Biological Pathways for PRKCI
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    VEGF Signaling
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    2 Reactome Pathways for PRKCI
        p75NTR recruits signalling complexes
    Tight junction interactions

    2 PharmGKB Pathways for PRKCI
        Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5 Kegg Pathways  (Kegg details for PRKCI):
        Rap1 signaling pathway
    Endocytosis
    Hippo signaling pathway
    Tight junction
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCI: 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCI (P417431, 2, 3 ENSP000002957974) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135011, 2, 3, ENSP000003744554EBI-286199,EBI-307104 MINT-8075920 MINT-8075934 MINT-8075945 I2D: score=8 STRING: ENSP00000374455
    PARD3Q8TEW01, 3, ENSP000003639214EBI-286199,EBI-81968 I2D: score=7 STRING: ENSP00000363921
    MARK4Q96L341, 3, ENSP000003008434EBI-286199,EBI-302319 I2D: score=4 STRING: ENSP00000300843
    TSC22D1Q157142, 3MINT-8275479 I2D: score=2 
    TTRP027662, 3MINT-8275869 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA8226978
    GO:0006612protein targeting to membrane NAS11257119
    GO:0007010cytoskeleton organization NAS11257119
    GO:0007015actin filament organization IEA--
    GO:0010976positive regulation of neuron projection development IMP10467349

    Find genes that share ontologies with PRKCI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    10 ApexBio Compounds for PRKCI     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCI available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCI (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    1 DrugBank Compound for PRKCI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Rbt205 Inhibitor-- --target--10592235

    1 Novoseek inferred chemical compound relationship for PRKCI gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gf 109203x 52.5 1 10101246 (1)



    Find genes that share compounds with PRKCI           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKCI gene: 
    NM_002740.5  

    Unigene Cluster for PRKCI:

    Protein kinase C, iota
    Hs.478199  [show with all ESTs]
    Unigene Representative Sequence: NM_002740
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295797(uc003fgs.2) ENST00000488541 ENST00000493761 ENST00000482353
    ENST00000476635(uc003fgt.2) ENST00000485837 ENST00000483697
    miRNA
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    hsa-miR-548j hsa-miR-548i hsa-miR-376b hsa-miR-219-5p hsa-miR-3613-3p hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-1299
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    Additional mRNA sequence: 

    AB451443.1 AK315342.1 BC022016.2 BC042405.1 L18964.1 L33881.1 

    12 DOTS entries:

    DT.451894  DT.100812320  DT.92326630  DT.121318585  DT.423329  DT.92438678  DT.95140902  DT.97769185 
    DT.120911514  DT.92438672  DT.99980092  DT.40200257 

    Selected AceView cDNA sequences (see all 149):

    AI279471 BQ014217 BU071082 CB135386 BU187127 AW236231 BQ006303 AA479362 
    AI480090 CK822800 BM704346 NM_002740 BM767350 BM840658 BM699472 BM670115 
    BG776886 AI920793 BU509388 T28044 BX108531 BU742623 AI783813 BG179816 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKCI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAACATT
    PRKCI Expression
    About this image


    PRKCI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Testis (Reproductive System)
    PRKCI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.478199

    UniProtKB/Swiss-Prot: KPCI_HUMAN, P41743
    Tissue specificity: Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues
    including pancreatic islets. Highly expressed in non-small cell lung cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCI: 
              Insulin Signaling Pathway in human mouse rat
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              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKCI gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkci1 , 5 protein kinase C, iota1, 5 90.64(n)1
    98.49(a)1
      3 (14.65 cM)5
    187591  NM_008857.31  NP_032883.21 
     309957475 
    chicken
    (Gallus gallus)
    Aves PRKCI1 protein kinase C, iota 83.93(n)
    95.07(a)
      424991  NM_001031319.1  NP_001026490.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCI6
    protein kinase C, iota
    81(a)
    1 ↔ 1
    3(7636896-7694656)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9672 Xenopus laevis protein kinase C subspecies lambda/iota more 81.18(n)    U12588.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkci2 protein kinase C, iota 79.19(n)   117507  AF390109.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aPKC1 , 3 oocyte determination protein
    serine/threonine more3
    atypical protein kinase C1
    67(a)
    (best of 2)3
    63.16(n)1
    69.83(a)1
      475941  NM_001043076.21  NP_001036541.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-31 pkc-3 60.53(n)
    60.71(a)
      173914  NM_062610.6  NP_495011.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKC16
    Protein serine/threonine kinase essential for cell...
    15(a)
    1 → many
    II(14241-17696) YBL105C


    ENSEMBL Gene Tree for PRKCI (if available)
    TreeFam Gene Tree for PRKCI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCI gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCE2  PKN12  PRKCA2  PRKCZ2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCI using alignment to 2 protein entries:     KPCI_HUMAN (see all proteins) (see all similar genes):
    PRKCZ    MARK4    PRKCB    AKT2    AKT1    AKT3
    KIN27    PRKCA    RPS6KB2    SGK2    PRKCG    RPS6KB1
    NUAK1    SGK1    PRKACB    PRKCH    RPS6KA3    RPS6KA5

    Find genes that share paralogs with PRKCI           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRKCI
    PGOHUM00000241470


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCI (see all 1909)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423224
    A metastatic melanoma sample4--see VAR_0423222 P L mis40--------
    rs722006171,2
    C--167350846(+) GTCTC-/AAAAAAA 1 -- int11Minor allele frequency- AA:0.00CSA 2
    rs730325841,2
    C,F--169938344(+) AGTAAG/ATTGTA 1 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1162171751,2
    F--169938373(+) TTTTTA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs10829771,2
    C,F,A,H--169938385(+) tgagaC/Tgggat 1 -- us2k119Minor allele frequency- T:0.37EA NS NA WA 2114
    rs1843525551,2
    --169938418(+) AGGGAA/CGGAGT 1 -- us2k10--------
    rs730325851,2
    C,F--169938597(+) TCTCCA/GATTAC 1 -- us2k13Minor allele frequency- G:0.10WA CSA 122
    rs730325861,2
    C,F--169938601(+) CAATTA/GCTGAA 1 -- us2k12Minor allele frequency- G:0.09WA 120
    rs730325891,2
    C,F--169938619(+) ATACCA/TAGTTT 1 -- us2k12Minor allele frequency- T:0.09WA 120
    rs1418691771,2
    C--169938634(+) TGGGA-/TTT   
       GTTTG
    TTTTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKCI (169940153 - 170023770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRKCI:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821366CNV Duplication20802225
    esv273479CNV Insertion20981092
    esv1665880CNV Insertion17803354
    esv268960CNV Insertion20981092
    nsv4112CNV Loss18451855
    nsv820125CNV Loss19587683
    esv32986CNV Gain17666407
    nsv7356OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCI
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600539    OMIM disorders: --


    Find genes that share disorders with PRKCI           About GenesLikeMe

    4 Novoseek inferred disease relationships for PRKCI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 36.9 3 18571841 (1), 16982626 (1), 18632643 (1)
    tumors 34.1 4 10037458 (1), 18234642 (1), 18538170 (1), 17626746 (1)
    hepatocellular carcinoma 20.4 1 19101699 (1)
    cancer 16.5 2 18571841 (1), 18794128 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRKCI (2 documents)

    Export disorders for PRKCI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PRKCI gene, integrated from 10 sources (see all 186):
    (articles sorted by number of sources associating them with PRKCI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. (PubMed id 7607695)1, 2, 3, 9 Mazzarella R.... D'Esposito M. (Genomics 1995)
    2. Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. (PubMed id 19327373)1, 2, 9 Staiger K.... Kellerer M. (Microvasc. Res. 2009)
    3. Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. (PubMed id 16125198)1, 2, 9 Messerschmidt A.... Blaesse M. (J. Mol. Biol. 2005)
    4. Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. (PubMed id 9346882)1, 2, 9 Murray N.R. and Fields A.P. (J. Biol. Chem. 1997)
    5. Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC- iota in human glioma cells. (PubMed id 15695176)1, 2, 9 Bicaku E.... Acevedo-Duncan M. (Tissue Cell 2005)
    6. Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. (PubMed id 14684752)1, 2, 9 Mamidipudi V.... Wooten M.W. (J. Biol. Chem. 2004)
    7. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. (PubMed id 21189248)1, 2 Justilien V.... Fields A.P. (J. Biol. Chem. 2011)
    8. PKC-? promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway. (PubMed id 21419810)1, 2 Desai S.... Acevedo-Duncan M. (Biochim. Biophys. Acta 2011)
    9. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. (PubMed id 19617897)1, 2 Justilien V. and Fields A.P. (Oncogene 2009)
    10. Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. (PubMed id 18270268)1, 2 Wald F.A....Salas P.J. (J. Cell Sci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5584 HGNC: 9404 AceView: PRKCI Ensembl:ENSG00000163558 euGenes: HUgn5584
    ECgene: PRKCI Kegg: 5584 H-InvDB: PRKCI

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCI Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKCI gene:
    Search GeneIP for patents involving PRKCI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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