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Aliases for PRKCI Gene

Aliases for PRKCI Gene

  • Protein Kinase C Iota 2 3
  • Protein Kinase C, Iota 2 3 5
  • Atypical Protein Kinase C-Lambda/Iota 3 4
  • PRKC-Lambda/Iota 3 4
  • APKC-Lambda/Iota 3 4
  • EC 2.7.11.13 4 63
  • NPKC-Iota 3 4
  • DXS1179E 3 4
  • EC 2.7.11 63
  • PKCI 3

External Ids for PRKCI Gene

Previous HGNC Symbols for PRKCI Gene

  • DXS1179E

Previous GeneCards Identifiers for PRKCI Gene

  • GC0XM096083
  • GC03P170989
  • GC03P171342
  • GC03P171261
  • GC03P171422
  • GC03P169940
  • GC03P167310

Summaries for PRKCI Gene

Entrez Gene Summary for PRKCI Gene

  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCI Gene

PRKCI (Protein Kinase C Iota) is a Protein Coding gene. Diseases associated with PRKCI include lung squamous cell carcinoma and lung cancer. Among its related pathways are Signaling by GPCR and Alzheimers Disease Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCI Gene

  • Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Tocris Summary for PRKCI Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCI Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCI Gene

Genomics for PRKCI Gene

Regulatory Elements for PRKCI Gene

Promoters for PRKCI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCI on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKCI Gene

Chromosome:
3
Start:
170,222,365 bp from pter
End:
170,305,982 bp from pter
Size:
83,618 bases
Orientation:
Plus strand

Genomic View for PRKCI Gene

Genes around PRKCI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCI Gene

Proteins for PRKCI Gene

  • Protein details for PRKCI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41743-KPCI_HUMAN
    Recommended name:
    Protein kinase C iota type
    Protein Accession:
    P41743
    Secondary Accessions:
    • D3DNQ4
    • Q8WW06

    Protein attributes for PRKCI Gene

    Size:
    596 amino acids
    Molecular mass:
    68262 Da
    Quaternary structure:
    • Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 (Thr-359 phosphorylated form). Interacts with VAMP2 (PubMed:17313651). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).
    SequenceCaution:
    • Sequence=AAA60171.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB17011.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22016.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKCI Gene

neXtProt entry for PRKCI Gene

Proteomics data for PRKCI Gene at MOPED

Post-translational modifications for PRKCI Gene

  • Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334. Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKCI Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCI (PKCI)

Domains & Families for PRKCI Gene

Gene Families for PRKCI Gene

Suggested Antigen Peptide Sequences for PRKCI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41743

UniProtKB/Swiss-Prot:

KPCI_HUMAN :
  • The PB1 domain mediates interaction with SQSTM1.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The PB1 domain mediates interaction with SQSTM1.
  • The C1 zinc finger does not bind diacylglycerol (DAG).
  • The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except the presence of a non-phosphorylatable residue in place of Ser, it modulates activity by competing with substrates.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PB1 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with PRKCI: view

Function for PRKCI Gene

Molecular function for PRKCI Gene

GENATLAS Biochemistry:
protein kinase C,iota polypeptide
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.5 uM for ATP (for recombinant purified PRKCI) {ECO:0000269 PubMed:10906326}; Vmax=7.4 pmol/min/mg enzyme {ECO:0000269 PubMed:10906326};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-412 (activation loop of the kinase domain) and Thr-564 (turn motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion.
UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Enzyme Numbers (IUBMB) for PRKCI Gene

Gene Ontology (GO) - Molecular Function for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRKCI: view
genes like me logo Genes that share phenotypes with PRKCI: view

Animal Models for PRKCI Gene

MGI Knock Outs for PRKCI:

Animal Model Products

miRNA for PRKCI Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCI Gene

Localization for PRKCI Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCI Gene

Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. {ECO:0000269 PubMed:15695176, ECO:0000269 PubMed:9566925}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCI Gene COMPARTMENTS Subcellular localization image for PRKCI gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
endosome 3
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005923 bicellular tight junction IEA --
GO:0043220 Schmidt-Lanterman incisure IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with PRKCI: view

Pathways & Interactions for PRKCI Gene

genes like me logo Genes that share pathways with PRKCI: view

Pathways by source for PRKCI Gene

SIGNOR curated interactions for PRKCI Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 8226978
GO:0006612 protein targeting to membrane NAS 11257119
GO:0007010 cytoskeleton organization NAS 11257119
GO:0010976 positive regulation of neuron projection development IMP 10467349
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with PRKCI: view

Drugs & Compounds for PRKCI Gene

(10) Drugs for PRKCI Gene - From: HMDB, DGIdb, DrugBank, Tocris, ApexBio, Novoseek, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 350
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Adenosine triphosphate Approved Nutra 0
Rbt205 Inhibitor Experimental Pharma Target 0

(9) Additional Compounds for PRKCI Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with PRKCI: view

Transcripts for PRKCI Gene

Unigene Clusters for PRKCI Gene

Protein kinase C, iota:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCI Gene

No ASD Table

Relevant External Links for PRKCI Gene

GeneLoc Exon Structure for
PRKCI
ECgene alternative splicing isoforms for
PRKCI

Expression for PRKCI Gene

mRNA expression in normal human tissues for PRKCI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKCI Gene

This gene is overexpressed in Lung (10.6), Placenta (8.1), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCI Gene



SOURCE GeneReport for Unigene cluster for PRKCI Gene Hs.478199

mRNA Expression by UniProt/SwissProt for PRKCI Gene

P41743-KPCI_HUMAN
Tissue specificity: Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.
genes like me logo Genes that share expression patterns with PRKCI: view

Protein tissue co-expression partners for PRKCI Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRKCI Gene

Orthologs for PRKCI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCI 35
  • 99.89 (n)
  • 100 (a)
PRKCI 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCI 36
  • 88 (a)
OneToOne
PRKCI 35
  • 94.46 (n)
  • 99.16 (a)
dog
(Canis familiaris)
Mammalia PRKCI 35
  • 94.74 (n)
  • 98.49 (a)
PRKCI 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkci 16
Prkci 36
  • 98 (a)
OneToOne
Prkci 35
  • 90.64 (n)
  • 98.49 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCI 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCI 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkci 35
  • 89.99 (n)
  • 98.66 (a)
chicken
(Gallus gallus)
Aves PRKCI 36
  • 94 (a)
OneToOne
PRKCI 35
  • 83.93 (n)
  • 95.07 (a)
lizard
(Anolis carolinensis)
Reptilia PRKCI 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.967 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prkci 35
  • 80.27 (n)
  • 92.84 (a)
Str.15038 35
zebrafish
(Danio rerio)
Actinopterygii prkci 36
  • 89 (a)
OneToOne
prkci 35
  • 76.08 (n)
  • 89.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta aPKC 36
  • 39 (a)
OneToMany
aPKC 37
  • 67 (a)
Pk17E 37
  • 33 (a)
aPKC 35
  • 63.16 (n)
  • 69.83 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 35
  • 60.53 (n)
  • 60.71 (a)
pkc-3 36
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for PRKCI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCI Gene

ENSEMBL:
Gene Tree for PRKCI (if available)
TreeFam:
Gene Tree for PRKCI (if available)

Paralogs for PRKCI Gene

Paralogs for PRKCI Gene

Pseudogenes.org Pseudogenes for PRKCI Gene

genes like me logo Genes that share paralogs with PRKCI: view

Variants for PRKCI Gene

Sequence variations from dbSNP and Humsavar for PRKCI Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_042322 A metastatic melanoma sample
VAR_042323 -
rs579909 -- 170,226,356(+) TCAGT(C/T)ATTAC intron-variant
rs511300 -- 170,248,916(-) GAACT(C/G)AGATC intron-variant
rs511377 -- 170,248,887(-) CTGGG(C/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCI Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv820125 CNV Loss 19587683
nsv821366 CNV Duplication 20802225
esv32986 CNV Gain 17666407
esv268960 CNV Insertion 20981092
esv273479 CNV Insertion 20981092
esv1665880 CNV Insertion 17803354
nsv4112 CNV Loss 18451855

Variation tolerance for PRKCI Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCI Gene

HapMap Linkage Disequilibrium report
PRKCI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCI Gene

Disorders for PRKCI Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKCI Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search PRKCI in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCI

Human Genome Epidemiology (HuGE) Navigator
PRKCI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCI
genes like me logo Genes that share disorders with PRKCI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCI Gene

Publications for PRKCI Gene

  1. Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. (PMID: 7607695) Mazzarella R. … D'Esposito M. (Genomics 1995) 2 3 4 23 67
  2. High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. (PMID: 19774416) Takagawa R. … Ohno S. (Ann. Surg. Oncol. 2010) 3 23
  3. Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma. (PMID: 19101699) Wang J.M. … Zou S.Q. (J. Surg. Res. 2009) 3 23
  4. Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells. (PMID: 19243387) Win H.Y. … Acevedo-Duncan M. (Cell Prolif. 2009) 3 23
  5. Expression of P-aPKC-iota, E-cadherin, and beta-catenin related to invasion and metastasis in hepatocellular carcinoma. (PMID: 19290490) Du G.S. … Zou S.Q. (Ann. Surg. Oncol. 2009) 3 23

Products for PRKCI Gene

  • Addgene plasmids for PRKCI

Sources for PRKCI Gene

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