Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRKCI Gene

Aliases for PRKCI Gene

  • Protein Kinase C Iota 2 3 5
  • Atypical Protein Kinase C-Lambda/Iota 3 4
  • PRKC-Lambda/Iota 3 4
  • APKC-Lambda/Iota 3 4
  • EC 2.7.11.13 4 56
  • NPKC-Iota 3 4
  • DXS1179E 3 4
  • Protein Kinase C Iota Type 3
  • Protein Kinase C, Iota 2
  • EC 2.7.11 56
  • PKCI 3

External Ids for PRKCI Gene

Previous HGNC Symbols for PRKCI Gene

  • DXS1179E

Previous GeneCards Identifiers for PRKCI Gene

  • GC0XM096083
  • GC03P170989
  • GC03P171342
  • GC03P171261
  • GC03P171422
  • GC03P169940
  • GC03P167310

Summaries for PRKCI Gene

Entrez Gene Summary for PRKCI Gene

  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCI Gene

PRKCI (Protein Kinase C Iota) is a Protein Coding gene. Diseases associated with PRKCI include Glioblastoma and Lung Squamous Cell Carcinoma. Among its related pathways are NFAT and Cardiac Hypertrophy and VEGF Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCZ.

UniProtKB/Swiss-Prot for PRKCI Gene

  • Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Tocris Summary for PRKCI Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCI Gene

Additional gene information for PRKCI Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCI Gene

Genomics for PRKCI Gene

GeneHancer (GH) Regulatory Elements for PRKCI Gene

Promoters and enhancers for PRKCI Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I170221 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 562.1 +0.9 936 3.4 HDGF PKNOX1 CLOCK ARNT NEUROD1 SIN3A ZNF2 ZBTB7B YY1 SLC30A9 PRKCI ENSG00000270096 MYNN SEC62-AS1 PHC3 RPL22P1 GPR160 RPL22L1 SLC7A14 LRRC34
GH03I169657 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.4 -558.7 -558697 12.4 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MECOM MYNN ENSG00000270096 PHC3 SEC62-AS1 PRKCI RPL22P1 SLC7A14 ACTRT3 ENSG00000242795
GH03I169771 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.2 -449.3 -449285 3.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MYNN PIR36992 TRV-AAC1-1 PHC3 PRKCI SEC62-AS1 CLDN11 LRRC34 ENSG00000270096 ENSG00000269889
GH03I170907 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.4 +686.5 686451 2.9 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B CBX5 ZNF302 EIF5A2 PHC3 SEC62-AS1 RPL22L1 PRKCI GC03M170953
GH03I169762 Promoter/Enhancer 1.8 Ensembl ENCODE 12.8 -457.9 -457946 3.1 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B GC03M169767 GC03M169768 GC03M169769 TERC ENSG00000277925 MYNN SEC62-AS1 PHC3 PRKCI RPL22P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKCI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKCI gene promoter:

Genomic Locations for PRKCI Gene

Genomic Locations for PRKCI Gene
chr3:170,222,365-170,305,982
(GRCh38/hg38)
Size:
83,618 bases
Orientation:
Plus strand
chr3:169,940,153-170,023,770
(GRCh37/hg19)

Genomic View for PRKCI Gene

Genes around PRKCI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCI Gene

Proteins for PRKCI Gene

  • Protein details for PRKCI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41743-KPCI_HUMAN
    Recommended name:
    Protein kinase C iota type
    Protein Accession:
    P41743
    Secondary Accessions:
    • D3DNQ4
    • Q8WW06

    Protein attributes for PRKCI Gene

    Size:
    596 amino acids
    Molecular mass:
    68262 Da
    Quaternary structure:
    • Forms a complex with SQSTM1 and MP2K5 (By similarity). Interacts directly with SQSTM1 (Probable). Interacts with IKBKB. Interacts with PARD6A, PARD6B and PARD6G. Part of a quaternary complex containing aPKC, PARD3, a PARD6 protein (PARD6A, PARD6B or PARD6G) and a GTPase protein (CDC42 or RAC1). Part of a complex with LLGL1 and PARD6B. Interacts with ADAP1/CENTA1. Interaction with SMG1, through the ZN-finger domain, activates the kinase activity. Interacts with CDK7. Forms a complex with RAB2A and GAPDH involved in recruitment onto the membrane of vesicular tubular clusters (VTCs). Interacts with ECT2 (Thr-359 phosphorylated form). Interacts with VAMP2 (PubMed:17313651). Interacts with WDFY2 (via WD repeats 1-3) (PubMed:16792529).
    SequenceCaution:
    • Sequence=AAA60171.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB17011.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22016.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKCI Gene

neXtProt entry for PRKCI Gene

Selected DME Specific Peptides for PRKCI Gene

P41743:
  • DEDIDWVQTEK
  • VNGGDLM
  • GIIYRDLK
  • HPFFRNVDWD
  • CINCKLLVHK
  • IHVFPCVPE
  • FLNKDPKERLGC
  • RLYELNKDSEL
  • EGDPCTVSSQ
  • YRRGARRW
  • YAMKVVKKELV
  • FQAKRFNR
  • TSTFCGTPNYIAPEILRG
  • RVIGRGSYAKVLLVRLKK
  • NTEDYLFQ
  • IDQSEFEGFEYINPLL
  • YRDLKLDN
  • KERLGCHPQTGFADI
  • VDWWALGVL
  • QIRIPRSLSV
  • GHIKLTD
  • LHSCFQT
  • MEQKQVVPPFKPNISGEFGLDNFD
  • EPVQLTPDD
  • YIAPEIL
  • YGFSVDWWALGVLMFEMMAGRSPFDI
  • HQVRVKAYYRGDIMITHFEPSIS
  • RDLKLDN
  • CGTPNYIAPE

Post-translational modifications for PRKCI Gene

  • Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334. Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus. Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation.

Other Protein References for PRKCI Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCI (PKCI)
  • Cloud-Clone Corp. Antibodies for PRKCI

Domains & Families for PRKCI Gene

Gene Families for PRKCI Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41743

UniProtKB/Swiss-Prot:

KPCI_HUMAN :
  • The PB1 domain mediates interaction with SQSTM1.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The PB1 domain mediates interaction with SQSTM1.
  • The C1 zinc finger does not bind diacylglycerol (DAG).
  • The pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins, except the presence of a non-phosphorylatable residue in place of Ser, it modulates activity by competing with substrates.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCI: view

Function for PRKCI Gene

Molecular function for PRKCI Gene

GENATLAS Biochemistry:
protein kinase C,iota polypeptide
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.5 uM for ATP (for recombinant purified PRKCI) {ECO:0000269 PubMed:10906326}; Vmax=7.4 pmol/min/mg enzyme {ECO:0000269 PubMed:10906326};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-412 (activation loop of the kinase domain) and Thr-564 (turn motif), need to be phosphorylated for its full activation (By similarity). Might also be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion.
UniProtKB/Swiss-Prot Function:
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

Enzyme Numbers (IUBMB) for PRKCI Gene

Phenotypes From GWAS Catalog for PRKCI Gene

Gene Ontology (GO) - Molecular Function for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 11724794
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity ISS --
GO:0005515 protein binding IPI 11257119
genes like me logo Genes that share ontologies with PRKCI: view
genes like me logo Genes that share phenotypes with PRKCI: view

Animal Models for PRKCI Gene

MGI Knock Outs for PRKCI:

Animal Model Products

miRNA for PRKCI Gene

Clone Products

  • Addgene plasmids for PRKCI

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCI Gene

Localization for PRKCI Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCI Gene

Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. {ECO:0000269 PubMed:15695176, ECO:0000269 PubMed:9566925}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCI gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
endosome 3
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (4)
  • Cytosol (4)
  • Microtubules (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA,IDA 11260256
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with PRKCI: view

Pathways & Interactions for PRKCI Gene

genes like me logo Genes that share pathways with PRKCI: view

Pathways by source for PRKCI Gene

SIGNOR curated interactions for PRKCI Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRKCI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 8226978
GO:0006612 protein targeting to membrane NAS 11257119
GO:0007010 cytoskeleton organization NAS 11257119
GO:0007015 actin filament organization IEA --
GO:0010976 positive regulation of neuron projection development IMP 10467349
genes like me logo Genes that share ontologies with PRKCI: view

Drugs & Compounds for PRKCI Gene

(13) Drugs for PRKCI Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 408
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
calcium Approved Nutra 0
Rbt205 Inhibitor Experimental Pharma Target 0

(5) Additional Compounds for PRKCI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCI Gene

Compound Action Cas Number
Calphostin C Potent, selective and photo-dependent PKC inhibitor 121263-19-2
CGP 53353 Selective inhibitor of PKCbetaII 145915-60-2
GF 109203X Protein kinase C inhibitor 133052-90-1
Oncrasin 1 Induces abnormal nuclear aggregation of PKCiota; proapoptotic 75629-57-1
Rottlerin Reported PKCdelta inhibitor 82-08-6

(1) ApexBio Compounds for PRKCI Gene

Compound Action Cas Number
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
genes like me logo Genes that share compounds with PRKCI: view

Drug Products

Transcripts for PRKCI Gene

Unigene Clusters for PRKCI Gene

Protein kinase C, iota:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRKCI

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCI Gene

No ASD Table

Relevant External Links for PRKCI Gene

GeneLoc Exon Structure for
PRKCI
ECgene alternative splicing isoforms for
PRKCI

Expression for PRKCI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKCI Gene

This gene is overexpressed in Lung (10.6), Placenta (8.1), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCI Gene



Protein tissue co-expression partners for PRKCI Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCI Gene:

PRKCI

SOURCE GeneReport for Unigene cluster for PRKCI Gene:

Hs.478199

mRNA Expression by UniProt/SwissProt for PRKCI Gene:

P41743-KPCI_HUMAN
Tissue specificity: Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.

Evidence on tissue expression from TISSUES for PRKCI Gene

  • Kidney(4.2)
  • Liver(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PRKCI: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCI Gene

Orthologs for PRKCI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCI 33 34
  • 99.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCI 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCI 33 34
  • 94.74 (n)
cow
(Bos Taurus)
Mammalia PRKCI 33 34
  • 94.46 (n)
mouse
(Mus musculus)
Mammalia Prkci 33 16 34
  • 90.64 (n)
rat
(Rattus norvegicus)
Mammalia Prkci 33
  • 89.99 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKCI 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCI 33 34
  • 83.93 (n)
lizard
(Anolis carolinensis)
Reptilia PRKCI 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkci 33
  • 80.27 (n)
Str.15038 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.967 33
zebrafish
(Danio rerio)
Actinopterygii prkci 33 34
  • 76.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta aPKC 35 33 34
  • 63.16 (n)
Pk17E 35
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-3 33 34
  • 60.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 70 (a)
OneToMany
Species where no ortholog for PRKCI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCI Gene

ENSEMBL:
Gene Tree for PRKCI (if available)
TreeFam:
Gene Tree for PRKCI (if available)

Paralogs for PRKCI Gene

Variants for PRKCI Gene

Sequence variations from dbSNP and Humsavar for PRKCI Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_042322 A metastatic melanoma sample p.Pro118Leu
rs1000053010 -- 170,258,384(+) C/T intron_variant
rs1000054831 -- 170,262,646(+) TTTTTTTT/TTTTTTT/TTTTTTTTT intron_variant
rs1000123876 -- 170,261,070(+) C/T intron_variant
rs1000124670 -- 170,258,091(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCI Gene

Variant ID Type Subtype PubMed ID
esv1665880 CNV insertion 17803354
esv32986 CNV gain 17666407
esv3598622 CNV gain 21293372
esv3598624 CNV gain 21293372
nsv1109561 CNV deletion 24896259
nsv4112 CNV deletion 18451855
nsv7356 OTHER inversion 18451855
nsv820125 CNV loss 19587683
nsv821366 CNV duplication 20802225

Variation tolerance for PRKCI Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKCI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCI Gene

Disorders for PRKCI Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKCI Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search PRKCI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRKCI

genes like me logo Genes that share disorders with PRKCI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCI Gene

Publications for PRKCI Gene