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PRKCH Gene

protein-coding   GIFtS: 71
GCID: GC14P061655

Protein Kinase C, Eta


(Previous symbol: PRKCL)
  See PRKCH-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Eta1 2     nPKC-eta2 3
PRKCL1 2 3 5     EC 2.7.11.133 8
PKCL2 3 5     Protein Kinase C Eta Type2
PKC-L2 3     EC 2.7.118

External Ids:    HGNC: 94031   Entrez Gene: 55832   Ensembl: ENSG000000270757   OMIM: 6054375   UniProtKB: P247233   

Export aliases for PRKCH gene to outside databases

Previous GC identifers: GC14P059114 GC14P055582 GC14P059778 GC14P060858 GC14P061788 GC14P041951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCH Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of
the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is
predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This
protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated
protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the
transcription activation of the transglutaminase 1 (TGM1) gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCH Gene:
PRKCH (protein kinase C, eta) is a protein-coding gene. Diseases associated with PRKCH include stroke, ischemic. GO annotations related to this gene include protein kinase C activity and enzyme binding. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCL_HUMAN, P24723
Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates
regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma
proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase
FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth
arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase
activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA
activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor
signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene
rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine
residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4
signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA
stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and
the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from
irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates
NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates
its mitochondrial localization

summary for PRKCH Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCH gene promoter:
         TBP   STAT1   STAT4   STAT1beta   FOXD3   STAT1alpha   TFIID   STAT2   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCH promoter sequence
   Search Chromatin IP Primers for PRKCH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

PRKCH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P061655:  view genomic region     (about GC identifiers)

Start:
61,654,277 bp from pter      End:
62,017,698 bp from pter
Size:
363,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KPCL_HUMAN, P24723 (See protein sequence)
Recommended Name: Protein kinase C eta type  
Size: 683 amino acids; 77828 Da
Subunit: Interacts with FYN and RALA (By similarity). Interacts with DGKQ
2 PDB 3D structures from and Proteopedia for PRKCH:
2FK9 (3D)        3TXO (3D)    
Secondary accessions: Q16246 Q8NE03

Explore the universe of human proteins at neXtProt for PRKCH: NX_P24723

Explore proteomics data for PRKCH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys404
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCH (P24723) (see all 25)
     VNGGDLM  GVLLYEM  DFGMCKE  YIAPEIL 


    See PRKCH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006246.2  
    ENSEMBL proteins: 
     ENSP00000451871   ENSP00000452129   ENSP00000452055   ENSP00000451789   ENSP00000451205  
     ENSP00000329127   ENSP00000450981   ENSP00000452588   ENSP00000450959   ENSP00000451793  
     ENSP00000451933   ENSP00000452330   ENSP00000451930   ENSP00000452528  
    Reactome Protein details: P24723

    PRKCH Human Recombinant Protein Products:

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    Novus Biologicals PRKCH Proteins
    Novus Biologicals PRKCH Lysates
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    LSBio Antibodies in human, mouse, rat for PRKCH

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PRKCH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, eta
    Protein kinase C
    Eta subfamily

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR014376 Prot_kin_PKC_delta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P24723

    ProtoNet protein and cluster: P24723

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCL_HUMAN, P24723
    Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol
    sensor and the C2 domain is a non-calcium binding domain
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCL_HUMAN, P24723
    Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
    that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates
    regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma
    proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase
    FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth
    arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase
    activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA
    activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor
    signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene
    rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine
    residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4
    signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA
    stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and
    the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from
    irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates
    NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
    Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
    Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates
    its mitochondrial localization
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by
    diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase
    domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004697protein kinase C activity TAS1986216
    GO:0004699calcium-independent protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with PRKCH           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRKCH:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Stronger migration 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prkch):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  tumorigenesis  vision/eye 

    Find genes that share phenotypes with PRKCH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKCH: Prkchtm1Cda Prkchtm1.2Gasc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKCH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKCH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCH

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PRKCH using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PRKCH:
    hsa-miR-187* hsa-miR-27a hsa-miR-513a-5p hsa-miR-944 hsa-miR-24 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidPRKCH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKCH

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PRKCH (NM_006255)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCH
    Addgene plasmids for PRKCH 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCL_HUMAN, P24723: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    mitochondrion2
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15632189
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA15632189
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PRKCH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCH About   (see all 65)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    3G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    4ErbB4 Pathway
    ErbB4 Pathway0.59
    IL-2 Pathway0.48
    ErbB Family Pathway0.59
    LPS Stimulated MAPK Signaling0.47
    Prolactin Signaling0.54
    UVC-Induced MAPK Signaling0.44
    Thrombopoietin Pathway0.51
    FGF Pathway0.37
    5Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37


    Find genes that share SuperPaths with PRKCH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCH (see all 77)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCH
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCH
        NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCH (see all 8)
        Signal transduction Erk Interactions- Inhibition of Erk
    Signal transduction Activation of PKC via G-Protein coupled receptor
    Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction cAMP signaling
    Transcription Transcription factor Tubby signaling pathways

    Selected BioSystems Pathways for PRKCH (see all 13)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    Wnt Signaling Pathway
    Insulin Signaling
    Wnt Signaling Pathway and Pluripotency


    2 Reactome Pathways for PRKCH
        Effects of PIP2 hydrolysis
    G alpha (z) signalling events

    3 PharmGKB Pathways for PRKCH
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    3 Kegg Pathways  (Kegg details for PRKCH):
        Vascular smooth muscle contraction
    Tight junction
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKCH: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRKCH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCH (P247232, 3 ENSP000003291274) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=3 STRING: ENSP00000266970
    ZBTB8OSQ8IWT03, ENSP000004176774I2D: score=3 STRING: ENSP00000417677
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    PRKD1Q151393, ENSP000003335684I2D: score=2 STRING: ENSP00000333568
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IMP--
    GO:0007165signal transduction TAS1986216
    GO:0007596blood coagulation TAS--
    GO:0010744positive regulation of macrophage derived foam cell differentiation ISS--
    GO:0030168platelet activation TAS--

    Find genes that share ontologies with PRKCH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    10 ApexBio Compounds for PRKCH     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCH (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    4 Novoseek inferred chemical compound relationships for PRKCH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol-sulfate 73.9 3 7819131 (3)
    rapamycin 26.6 1 16832347 (1)
    nitric oxide 12 8 14719189 (2), 9677361 (1), 14732335 (1), 18432406 (1)
    cholesterol 0 1 7819131 (1)



    Find genes that share compounds with PRKCH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKCH gene: 
    NM_006255.3  

    Unigene Cluster for PRKCH:

    Protein kinase C, eta
    Hs.333907  [show with all ESTs]
    Unigene Representative Sequence: BC037268
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000555185 ENST00000557294 ENST00000556778 ENST00000555542 ENST00000555906
    ENST00000554835 ENST00000332981(uc001xfn.3) ENST00000555082(uc010tsa.2 uc010tsb.2)
    ENST00000552875 ENST00000553830 ENST00000553831 ENST00000553726 ENST00000553265
    ENST00000556164 ENST00000557585 ENST00000557473 ENST00000553889 ENST00000557559

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    Additional mRNA sequence: 

    AB451313.1 AK290183.1 AK296158.1 AK300864.1 BC001000.2 BC037268.1 EF611285.1 M55284.1 
    S74620.1 

    17 DOTS entries:

    DT.456426  DT.120769361  DT.91855416  DT.100023829  DT.100776182  DT.100776206  DT.120769291  DT.101960364 
    DT.120769323  DT.40118116  DT.91742402  DT.92422921  DT.95074397  DT.100728564  DT.101954332  DT.91681972 
    DT.91842861 

    Selected AceView cDNA sequences (see all 138):

    AW008462 BU682213 CF126408 NM_006255 BF436095 AI492197 CK824833 BM997800 
    BE503787 BM693005 BM457208 AA643908 AX775931 BX356566 CA447784 AA120775 
    BP367689 AW082917 AI279081 AI391512 BU620154 BM855935 BX956727 T29494 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKCH (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:        -                                         -                       -     -           -     -     -                                 
    SP2:                                                                                                  -     -                                 
    SP3:                                                                                                                                          
    SP4:                                                                                                        -                                 
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PRKCH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKCH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGACCA
    PRKCH Expression
    About this image


    PRKCH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Epithelial Cells
             Granular Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)
             Granular Keratinocytes Stratified Epidermis
     
     Gonad
             Primordial germ cell-like cells
    PRKCH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333907

    UniProtKB/Swiss-Prot: KPCL_HUMAN, P24723
    Tissue specificity: Most abundant in lung, less in heart and skin

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKCH: 
              Polycomb & Trithorax Target Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCH gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkch1 , 5 protein kinase C, eta1, 5 90.03(n)1
    97.8(a)1
      12 (30.81 cM)5
    187551  NM_008856.31  NP_032882.21 
     735847975 
    chicken
    (Gallus gallus)
    Aves PRKCH1 protein kinase C, eta 79.31(n)
    86.45(a)
      423518  XM_421417.4  XP_421417.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCH6
    protein kinase C, eta
    86(a)
    1 ↔ 1
    1(3334397-3402896)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkch1 protein kinase C, eta 72.1(n)
    77.48(a)
      100151731  XM_002939475.2  XP_002939521.2 
    zebrafish
    (Danio rerio)
    Actinopterygii prkcha1 protein kinase C, eta, a 66.22(n)
    67.9(a)
      100144561  NM_001123056.1  NP_001116528.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc98E3 protein amino acid phosphorylation
    protein serine/threonine more
    53(a)
    (best of 2)
      98F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea R12G8.13 Phorbol esters / diacylglycerol binding
    domain more
    46(a)   V(17750323-17751976)   --


    ENSEMBL Gene Tree for PRKCH (if available)
    TreeFam Gene Tree for PRKCH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCH gene
    PRKCQ2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCH using alignment to 16 protein entries:     KPCL_HUMAN (see all proteins) (see all similar genes):
    PRKCE    SGK494    PRKCZ    PRKD1    RASSF1    PRKCA
    KIN27    AKT1    AKT3    AKT2    PRKACB    PKN1
    SGK2    PRKCD    PRKACA    PRKCQ    RPS6KA1    RPS6KB1

    Find genes that share paralogs with PRKCH           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PRKCH
    PGOHUM00000261855 PGOHUM00000261856


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCH (see all 5317)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423174
    A colorectal adenocarcinoma sample4--see VAR_0423172 T I mis40--------
    rs22305001,2,,4
    C,F,Hother142909064(+) CAAGAG/ATAAAA 2 /I /V mis112Minor allele frequency- A:0.01MN NS EA NA EU 6953
    rs587944661,2
    C--41967210(+) AAAAA-/A/AA  
            
    GTACA
    1 -- int11NA 2
    rs1113041551,2
    F--42000418(+) TCACCG/ATGTTG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs355116661,2
    C--42035281(+) CAAGA-/AC    
       
    /C/CA
    ATACC
    1 -- int11CSA 2
    rs560567051,2
    C--42035282(+) AAGAA-/AC/CA 
            
    TACCC
    1 -- int10--------
    rs2007253371,2
    --42043729(+) AGCGC-/CACCCCC 1 -- int10--------
    rs570226591,2
    C--42043740(+) CCCCC-/G/GCC 
            
    CCGCC
    2 -- int1 cds11NA 2
    rs1125361781,2
    C,F--42054554(+) ATTGGC/TACTGA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs361182221,2
    C--42061507(+) AAGGG-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PRKCH (61654277 - 61904277 bp, first 250kb of PRKCH)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKCH (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422159CNV Deletion20811451
    esv2657744CNV Deletion23128226
    esv2663429CNV Deletion23128226
    nsv1297CNV Insertion18451855
    nsv517477CNV Loss19592680
    nsv470650CNV Loss18288195
    esv1002305CNV Loss20482838
    nsv517729CNV Loss19592680
    nsv902006CNV Loss21882294
    nsv514743CNV Loss21397061

    Human Gene Mutation Database (HGMD): PRKCH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCH
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605437   
    OMIM disorders: 601367  
    UniProtKB/Swiss-Prot: KPCL_HUMAN, P24723
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 1 disease for PRKCH:    
    About MalaCards
    stroke, ischemic


    Find genes that share disorders with PRKCH           About GenesLikeMe

    3 Novoseek inferred disease relationships for PRKCH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 48.5 4 11772428 (1), 15489897 (1), 17146445 (1), 16832347 (1)
    rheumatoid arthritis 3 1 17195206 (1)
    tumors 0 1 11112424 (1)

    Genetic Association Database (GAD): PRKCH
    Human Genome Epidemiology (HuGE) Navigator: PRKCH (13 documents)

    Export disorders for PRKCH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCH gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with PRKCH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. (PubMed id 1545821)1, 2, 3 Bacher N....Livneh E. (Mol. Cell. Biol. 1992)
    2. Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. (PubMed id 1986216)1, 2, 3 Bacher N.... Livneh E. (Mol. Cell. Biol. 1991)
    3. Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population. (PubMed id 17195206)1, 4, 9 Takata Y....Itakura M. (Arthritis Rheum. 2007)
    4. A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. (PubMed id 17206144)1, 2, 9 Kubo M.... Kiyohara Y. (Nat. Genet. 2007)
    5. [Genetic risk factors of ischemic stroke identified by a genome-wide association study]. (PubMed id 19069168)1, 4, 9 Kubo M. (Brain Nerve 2008)
    6. The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway. (PubMed id 17146445)1, 2, 9 Uht R.M.... Hussaini I.M. (Oncogene 2007)
    7. Protein kinase C-eta regulates resistance to UV- and gamma- irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. (PubMed id 11772428)1, 2, 9 Hussaini I.M.... Vandenberg S.R. (Neuro-oncol. 2002)
    8. The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population. (PubMed id 19520989)1, 4, 9 Wu L....Wang X. ( a journal of cerebral circulation 2009)
    9. Association between PRKCH gene polymorphisms and subcortical silent brain infarction. (PubMed id 18164711)1, 4, 9 Serizawa M....Kato N. (Atherosclerosis 2008)
    10. PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. (PubMed id 15489897)1, 2, 9 Aeder S.E.... Hussaini I.M. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5583 HGNC: 9403 AceView: PRKCH Ensembl:ENSG00000027075 euGenes: HUgn5583
    ECgene: PRKCH Kegg: 5583 H-InvDB: PRKCH

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKCH gene:
    Search GeneIP for patents involving PRKCH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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