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PRKCG Gene

protein-coding   GIFtS: 74
GCID: GC19P054382

Protein Kinase C, Gamma


(Previous symbols: PKCG, SCA14)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Gamma1 2     EC 2.7.11.133 8
PKCG1 2 3 5     PKCC2 5
PKC-gamma1 2 3     Protein Kinase C Gamma Type2
SCA141 2 5     EC 2.7.118

External Ids:    HGNC: 94021   Entrez Gene: 55822   Ensembl: ENSG000001265837   OMIM: 1769805   UniProtKB: P051293   

Export aliases for PRKCG gene to outside databases

Previous GC identifers: GC19P055031 GC19P054810 GC19P059061 GC19P059077 GC19P050704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCG Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets
and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for
phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and
is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members.
This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to
neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and
long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this
kinase may be involved in neuropathic pain development. Defects in this protein have been associated with
neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCG Gene:
PRKCG (protein kinase C, gamma) is a protein-coding gene. Diseases associated with PRKCG include spinocerebellar ataxia type 14, and spinocerebellar ataxia type14. GO annotations related to this gene include calcium-dependent protein kinase C activity and protein kinase activity. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4
and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and
alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity
after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by
increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist
3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and
phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis,
excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term
potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in
desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical
for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May
modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the
phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in
nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the
allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance
to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A)
receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes,
and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury.
Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing
cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates
connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction
activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates
p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage

summary for PRKCG Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCG gene promoter:
         Egr-3   TBP   Sp1   HSF1 (long)   GATA-1   CREB   deltaCREB   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCG promoter sequence
   Search Chromatin IP Primers for PRKCG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

PRKCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054382:  view genomic region     (about GC identifiers)

Start:
54,382,444 bp from pter      End:
54,410,906 bp from pter
Size:
28,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129 (See protein sequence)
Recommended Name: Protein kinase C gamma type  
Size: 697 amino acids; 78448 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain
Subunit: Interacts with GRIA4 (By similarity). Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53
2 PDB 3D structures from and Proteopedia for PRKCG:
2E73 (3D)        2UZP (3D)    

Explore the universe of human proteins at neXtProt for PRKCG: NX_P05129

Explore proteomics data for PRKCG at MOPED

Post-translational modifications: 

  • Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4 (By similarity)1
  • Ubiquitinated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCG (P05129) (see all 40)
     LNPVWNE  FYAAEIA  CKGFLTK  IKITDFG 


    See PRKCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002730.1  
    ENSEMBL proteins: 
     ENSP00000471544   ENSP00000471271   ENSP00000263431   ENSP00000387919   ENSP00000443493  
     ENSP00000440541   ENSP00000438090  
    Reactome Protein details: P05129

    PRKCG Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCG Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PRKCG
    OriGene Protein Over-expression Lysate for PRKCG
    OriGene MassSpec for PRKCG
    OriGene Custom Protein Services for PRKCG
    GenScript Custom Purified and Recombinant Proteins Services for PRKCG
    Novus Biologicals PRKCG Proteins
    Novus Biologicals PRKCG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PRKCG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCG
    R&D Systems Antibodies for PRKCG (PKC gamma)
    Cell Signaling Technology (CST) Antibodies for PRKCG  (PKCG)
    OriGene Antibodies for PRKCG
    OriGene Custom Antibody Services for PRKCG
    Novus Biologicals PRKCG Antibodies
    Abcam antibodies for PRKCG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKCG
    LSBio Antibodies in human, mouse, rat for PRKCG

    PRKCG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, gamma
    Protein kinase C
    Alpha subfamily

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P05129

    ProtoNet protein and cluster: P05129

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    PRKCG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCG_HUMAN, P05129
    Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
    plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4
    and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and
    alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity
    after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by
    increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist
    3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and
    phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis,
    excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term
    potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in
    desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical
    for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May
    modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the
    phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in
    nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the
    allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance
    to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A)
    receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes,
    and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury.
    Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing
    cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates
    connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction
    activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates
    p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and
    diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the
    kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full
    activation

         Genatlas biochemistry entry for PRKCG:
    protein kinase C,gamma polypeptide

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15808853
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004697protein kinase C activity TAS3755548
    GO:0004698calcium-dependent protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    PRKCG for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PRKCG:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability after Chla  Gemcitabine induced cell-death 
     Increased colony dispersion (i 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prkcg):
     behavior/neurological  immune system  integument  nervous system  normal 
     taste/olfaction 

    PRKCG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkcgtm1Stl for PRKCG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKCG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKCG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCG

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKCG:
    hsa-mir-335-5p (MIRT017708)

    Block miRNA regulation of human, mouse, rat PRKCG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCG (see all 12):
    hsa-miR-186* hsa-miR-766 hsa-miR-519e* hsa-miR-646 hsa-miR-515-5p hsa-miR-2355-5p hsa-miR-4310 hsa-miR-532-3p
    SwitchGear 3'UTR luciferase reporter plasmidPRKCG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKCG
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCG

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCG (see all 7)
    OriGene ORF clones in mouse, rat for PRKCG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCG (NM_002739)
    Sino Biological Human cDNA Clone for PRKCG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCG
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKCG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCG_HUMAN, P05129: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane;
    Peripheral membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell
    projection, dendrite (By similarity). Note=Translocates to synaptic membranes on stimulation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ISS--
    GO:0030054cell junction IEA--

    PRKCG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCG About   (see all 108)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    Development Angiotensin signaling via beta Arrestin0.39
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    3Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.67
    PLC-gamma1 signalling0.94
    G-protein mediated events0.65
    CaM pathway0.93
    Phospholipase C-mediated cascade0.59
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    5Glioma
    Glioma0.51
    Signaling Pathways in Glioblastoma0.36
    Non-small cell lung cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PRKCG
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCG (see all 78)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCG
        Ca, cAMP and Lipid Signaling

    4 Tocris Bioscience Pathways for PRKCG
        Insulin Pathway
    NF-kappaB Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCG (see all 13)
        Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction cAMP signaling
    Development EGFR signaling pathway
    Development Angiotensin signaling via beta-Arrestin
    Signal transduction Erk Interactions- Inhibition of Erk

    Selected BioSystems Pathways for PRKCG (see all 14)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway
    G Protein Signaling Pathways

    1 Sino Biological Pathway for PRKCG
        VEGF Signaling

    Selected Reactome Pathways for PRKCG (see all 6)
        Disinhibition of SNARE formation
    Calmodulin induced events
    WNT5A-dependent internalization of FZD4
    Response to elevated platelet cytosolic Ca2+
    Trafficking of GluR2-containing AMPA receptors

    4 PharmGKB Pathways for PRKCG
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCG) (see all 48):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway


    PRKCG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCG (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCG (P051292, 3 ENSP000002634314) via UniProtKB, MINT, STRING, and/or I2D (see all 226)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCHCR1Q8TD312, 3, ENSP000003795664MINT-2873755 I2D: score=3 STRING: ENSP00000379566
    ENSG00000206355Q8TD312, 3MINT-2873755 I2D: score=3 
    ENSG00000206457Q8TD312, 3MINT-2873755 I2D: score=3 
    ENSG00000234114Q8TD312, 3MINT-2873755 I2D: score=3 
    PTPN1P180312, 3, ENSP000003606834MINT-6795361 MINT-6794972 I2D: score=1 STRING: ENSP00000360683
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS3755548
    GO:0006950response to stress ----
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007202activation of phospholipase C activity TAS--

    PRKCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKCG
    10 ApexBio Compounds for PRKCG     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCG (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    Selected Novoseek inferred chemical compound relationships for PRKCG gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 83.6 7 12954613 (2), 17784814 (1)
    aristolochic acid 50.5 1 15917990 (1)
    gf 109203x 44.9 1 15917990 (1)
    phorbol 12,13-dibutyrate 44.8 8 8051084 (4)
    phosphatidylserine 42.5 5 8051084 (2), 17878267 (1)
    threonine 42.1 5 12438709 (1), 16189624 (1), 12644968 (1)
    phorbol 39.7 1 10428394 (1)
    12-o-tetradecanoylphorbol 13-acetate 36.5 3 11313866 (2), 1388136 (1)
    serine 31 7 12438709 (1), 16189624 (1), 18652891 (1), 12644968 (1) (see all 5)
    calcium 24 25 16571747 (3), 17878267 (3), 8051084 (3), 15917990 (2) (see all 12)



    PRKCG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKCG gene: 
    NM_002739.3  

    Unigene Cluster for PRKCG:

    Protein kinase C, gamma
    Hs.631564  [show with all ESTs]
    Unigene Representative Sequence: NM_002739
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479081 ENST00000474397 ENST00000263431(uc002qcq.1 uc010yeh.1)
    ENST00000419486 ENST00000540413(uc010eqz.1 uc010yef.1 uc010yeg.1)
    ENST00000536044 ENST00000542049
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209671.1 AF345987.1 AK296412.1 AK296434.1 AK302958.1 AK303741.1 AK312302.1 BC047876.1 
    M13977.1 Z15114.1 

    2 DOTS entries:

    DT.411273  DT.95351170 

    Selected AceView cDNA sequences (see all 41):

    AL133962 H14047 F06530 BX101823 F09673 T16339 BC047876 T28078 
    Z15114 NM_002739 AA338339 F12027 BI490011 F02800 F07006 CB155791 
    T65563 M13977 BI757265 BM926293 Z40116 H50904 T65631 AF345987 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCTGTCT
    PRKCG Expression
    About this image


    PRKCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    PRKCG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631564

    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
    Tissue specificity: Expressed in Purkinje cells of the cerebellar cortex

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCG (see all 8): 
              mTOR Signaling in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcg1 , 5 protein kinase C, gamma1, 5 89.48(n)1
    99(a)1
      7 (1.93 cM)5
    187521  NM_011102.31  NP_035232.11 
     33035325 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCG6
    protein kinase C, gamma
    81(a)
    1 ↔ 1
    GL343329.1(327164-401723)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkcg1 protein kinase C, gamma 74.3(n)
    83.11(a)
      100496779  XM_004916331.1  XP_004916388.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkcg1 protein kinase C, gamma 67.44(n)
    70.96(a)
      100003514  XM_001921680.2  XP_001921715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc53E3 protein amino acid phosphorylation
    protein serine/threonine more
    64(a)
    (best of 2)
      53E2   --
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-23 Protein kinase C 62(a)
    (best of 2)
      X(9414106-9420963)   --


    ENSEMBL Gene Tree for PRKCG (if available)
    TreeFam Gene Tree for PRKCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCG gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  
    PRKCD2  PKN32  PKN22  
    Selected SIMAP similar genes for PRKCG using alignment to 7 protein entries:     KPCG_HUMAN (see all proteins) (see all similar genes):
    PRKCA    PRKCB    PRKD1    RPH3A    PKN2    PRKCZ
    KIN27    MARK4    SYT5    PRKCE    PRKD2    PRKCI
    SYT9    DOC2A    PRKACB    PIK3C2B    RPS6KA3    AKT3

    PRKCG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCG (see all 815)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0170604
    Spinocerebellar ataxia 14 (SCA14)4--see VAR_0170602 H Y mis40--------
    VAR_0170614
    Spinocerebellar ataxia 14 (SCA14)4--see VAR_0170612 S P mis40--------
    VAR_0170624
    Spinocerebellar ataxia 14 (SCA14)4--see VAR_0170622 G D mis40--------
    rs1219185111,2
    Cpathogenic154392907(+) ACAAAC/TACAAG 2 H Y mis10--------
    rs1219185181,2
    Cpathogenic154392909(+) AAACAC/GAAGTT 2 H Q mis10--------
    rs1219185141,2
    Cpathogenic154392959(+) CTGTGA/GCTCCC 2 D G mis10--------
    rs1219185121,2
    Cpathogenic154392961(+) GTGGCC/TCCCTC 2 P S mis10--------
    rs1219185151,2
    Cpathogenic154392986(+) GCACCA/GGGGCA 2 Q R mis10--------
    rs1219185131,2
    Cpathogenic154392989(+) CCAGGA/GCATGA 2 D G mis10--------
    rs1219185171,2
    Cpathogenic154401354(+) AAGGCA/GGTTTT 2 S G mis10--------

    HapMap Linkage Disequilibrium report for PRKCG (54382444 - 54410906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRKCG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718846CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv2541CNV Loss18451855
    nsv833876CNV Loss17160897

    Human Gene Mutation Database (HGMD): PRKCG
    Locus Specific Mutation Databases (LSDB): PRKCG

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCG
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176980   
    OMIM disorders: 605361  
    UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129
  • Spinocerebellar ataxia 14 (SCA14) [MIM:605361]: Spinocerebellar ataxia is a clinically and genetically
    heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor
    coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement
    of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA). Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for PRKCG (see all 38):    
    About MalaCards
    spinocerebellar ataxia type 14    spinocerebellar ataxia type14    spinocerebellar ataxia    hepatopulmonary syndrome
    trypanosomiasis    ataxia    peutz-jeghers syndrome    cerebellar ataxia
    tetanus    major depressive disorder    myotonic dystrophy    teratocarcinoma
    retinitis pigmentosa    neuronitis    hiv-1    osteoporosis
    cholera    huntington's disease    retinitis    osteosarcoma

    2 diseases from the University of Copenhagen DISEASES database for PRKCG:
    Spinocerebellar ataxia     Cerebellar ataxia

    PRKCG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for PRKCG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sca14 96.9 59 18577575 (5), 15618281 (4), 16763984 (3), 14676051 (3) (see all 16)
    spinocerebellar ataxias 85.2 25 18577575 (2), 16763984 (2), 15313841 (2), 17562946 (1) (see all 13)
    neurodegenerative diseases 41.5 8 18577575 (1), 16763984 (1), 17822669 (1)
    tumors 3.21 1 9113106 (1)

    GeneTests: PRKCG
    GeneReviews: PRKCG
    Genetic Association Database (GAD): PRKCG
    Human Genome Epidemiology (HuGE) Navigator: PRKCG (8 documents)

    Export disorders for PRKCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCG gene, integrated from 10 sources (see all 255):
    (articles sorted by number of sources associating them with PRKCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. (PubMed id 3755548)1, 2, 3 Coussens L.... Ullrich A. (Science 1986)
    2. The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. (PubMed id 17508994)1, 4, 9 Schlaepfer I.R....Ehringer M.A. (Addict Biol 2007)
    3. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. (PubMed id 12644968)1, 2, 9 Chen D.-H.... Raskind W.H. (Am. J. Hum. Genet. 2003)
    4. New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14. (PubMed id 16193476)1, 4, 9 Klebe S....Stevanin G. (Ann. Neurol. 2005)
    5. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    6. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1, 2 Del RincA^n S.V....Spruck C. (PLoS ONE 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (Cell 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Protein kinase C gamma (PKC gamma): function of neuron specific isotype. (PubMed id 12417016)1, 2 Saito N. and Shirai Y. (J. Biochem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5582 HGNC: 9402 AceView: PRKCG Ensembl:ENSG00000126583 euGenes: HUgn5582
    ECgene: PRKCG Kegg: 5582 H-InvDB: PRKCG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCG Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the PRKCG genehttp://www.retina-international.org/files/sci-news/prkcgmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PRKCG[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKCG gene:
    Search GeneIP for patents involving PRKCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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