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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRKCG Gene

protein-coding GIFtS: 76
GCID: GC19P054382

protein kinase C, gamma

(Previous symbols: PKCG, SCA14)

Explore 40 diseases affiliated with
PRKCG via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase C, Gamma¹ ²		EC 2.7.11.13³ ⁸
PKCG¹ ² ³ ⁵		MGC57564¹
PKCC¹ ² ⁵		Protein Kinase C Gamma Type²
SCA14¹ ² ⁵		EC 2.7.11⁸
PKC-Gamma¹

External Ids:	HGNC: 9402¹	Entrez Gene: 5582²	Ensembl: ENSG00000126583⁷	OMIM: 176980⁵	UniProtKB: P05129³

Export aliases for PRKCG gene to outside databases

Previous GC identifers: GC19P055031 GC19P054810 GC19P059061 GC19P059077 GC19P050704

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKCG:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium

and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known

to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class

of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct

roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed

solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that

several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically

require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain

development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14

(SCA14). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129

Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that

plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and

GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol,

mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after

oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing

plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist

3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and

phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity,

memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but

may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid

receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance

of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid

receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid

receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in

neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral

inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral

effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia

modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of

necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing

fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon

hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction

plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By

similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage

summary for PRKCG:

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation

mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by

phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive

novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and

phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol

esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain

via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation

of multiple target proteins, which are involved in signal transduction pathways including, but not limited

to, receptor desensitization, modulation of membrane structure events, regulation of transcription,

regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRKCG gene promoter:
Egr-3 TBP Sp1 HSF1 (long) GATA-1 CREB deltaCREB HSF1short Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKCG promoter sequence

Search SABiosciences Chromatin IP Primers for PRKCG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4

PRKCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCG gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P054382: view genomic region (about GC identifiers)

Start:	54,382,444 bp from pter	End:	54,410,906 bp from pter
Size:	28,463 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129 (See protein sequence)

Recommended Name: Protein kinase C gamma type

Size: 697 amino acids; 78448 Da

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain

Subunit: Interacts with GRIA4 (By similarity). Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53

Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane;

Peripheral membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell projection,

dendrite (By similarity). Note=Translocates to synaptic membranes on stimulation (By similarity)

2 PDB 3D structures from and Proteopedia for PRKCG:

2E73 (3D)

2UZP (3D)

Explore the universe of human proteins at neXtProt for PRKCG: NX_P05129

Post-translational modifications:

Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05129

4/40 DME Specific Peptides for PRKCG (P05129) (see all 40)

LNPVWNE

FYAAEIA

CKGFLTK

IKITDFG

PRKCG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002730.1

ENSEMBL proteins:

ENSP00000263431 ENSP00000387919 ENSP00000443493 ENSP00000440541 ENSP00000438090

Reactome Protein details: P05129
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant PRKCG Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PRKCG OriGene Protein Over-expression Lysate: PRKCG OriGene Custom Protein Services for PRKCG
	GenScript Custom Purified and Recombinant Proteins Services for PRKCG
	Novus Biologicals PRKCG Proteins Novus Biologicals PRKCG Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PRKCG
	Browse Proteins at Uscn

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	ISS	--

PRKCG for ontologies About GeneDecksing

PRKCG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCG
	R&D Systems Antibodies for PRKCG (PKC gamma)
	Cell Signaling Technology (CST) Antibodies for PRKCG (PKCG)
	OriGene Antibodies (see all 2): PRKCG OriGene Custom Antibody Services for PRKCG
	GenScript Superior Antibodies for PRKCG
	Novus Biologicals PRKCG Antibodies
	Abcam antibodies for PRKCG
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for PRKCG

Assay Products for PRKCG:

	EMD Millipore Kits and Assays for the Analysis of PRKCG
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PRKCG
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRKCG for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR020454 DAG/PE-bd

IPR011009 Kinase-like_dom

IPR017892 Pkinase_C

Graphical View of Domain Structure for InterPro Entry P05129

ProtoNet protein and cluster: P05129

3 Blocks protein families:

IPB000008 C2 domain

IPB000961 Protein kinase C-terminal domain

IPB002219 Protein kinase C

UniProtKB/Swiss-Prot: KPCG_HUMAN, P05129

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 C2 domain

Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: