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Aliases for PRKCE Gene

Aliases for PRKCE Gene

  • Protein Kinase C Epsilon 2 3 5
  • NPKC-Epsilon 3 4
  • EC 2.7.11.13 4 58
  • PKCE 3 4
  • Protein Kinase C Epsilon Type 3
  • Protein Kinase C, Epsilon 2
  • EC 2.7.11 58

External Ids for PRKCE Gene

Previous GeneCards Identifiers for PRKCE Gene

  • GC02P045897
  • GC02P046047
  • GC02P045853
  • GC02P045790

Summaries for PRKCE Gene

Entrez Gene Summary for PRKCE Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCE Gene

PRKCE (Protein Kinase C Epsilon) is a Protein Coding gene. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Development Slit-Robo signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCH.

UniProtKB/Swiss-Prot for PRKCE Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Tocris Summary for PRKCE Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCE Gene

Additional gene information for PRKCE Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCE Gene

Genomics for PRKCE Gene

Regulatory Elements for PRKCE Gene

Enhancers for PRKCE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H045935 1.5 Ensembl ENCODE dbSUPER 11.7 +285.1 285132 1 ATF1 ZFP64 ARID4B SIN3A BRCA1 ZNF2 ZNF766 ZNF143 ZNF207 FOS PRKCE LOC105374580 GC02M046004 GC02P045738
GH02H045937 1.5 Ensembl ENCODE dbSUPER 11.7 +287.7 287721 2 PKNOX1 FOXA2 SIN3A FEZF1 YY1 ZNF143 ATF7 FOS TSHZ1 REST LOC100506142 PRKCE LOC105374580 GC02M046004 GC02P045738
GH02H046064 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +415.7 415692 4 ATF1 SIN3A BRCA1 ZNF766 FOS ATF7 DEK MEF2D MAFF ATF4 EPAS1 ENSG00000228925 SOCS5 ENSG00000231336 ENSG00000226548 LINC01119 LOC105374580 PRKCE ENSG00000232696 RPL26P15
GH02H045821 1.4 Ensembl ENCODE dbSUPER 11.1 +171.6 171589 3 FOXA2 NFIB SIN3A FEZF1 BATF RAD21 YY1 ZNF366 SCRT2 FOS PRKCE SOCS5 LOC105374580 GC02P045738 GC02M046004
GH02H045887 1.4 Ensembl ENCODE dbSUPER 10.8 +239.1 239138 5 PKNOX1 FOXA2 FEZF1 BATF ATF7 RUNX3 CREM EGR2 SMARCA5 ZNF362 PRKCE LOC105374580 GC02M046004 GC02P045738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCE on UCSC Golden Path with GeneCards custom track

Promoters for PRKCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000290745 -115 2801 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766
ENSR00000116454 1585 201 SP3 L3MBTL2 MAX MNT ZBTB8A ZFP69B ZFHX2 ZNF692 ZNF341 KLF9

Genomic Location for PRKCE Gene

Chromosome:
2
Start:
45,651,315 bp from pter
End:
46,187,990 bp from pter
Size:
536,676 bases
Orientation:
Plus strand

Genomic View for PRKCE Gene

Genes around PRKCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCE Gene

Proteins for PRKCE Gene

  • Protein details for PRKCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02156-KPCE_HUMAN
    Recommended name:
    Protein kinase C epsilon type
    Protein Accession:
    Q02156
    Secondary Accessions:
    • B0LPH7
    • Q32MQ3
    • Q53SL4
    • Q53SM5
    • Q9UE81

    Protein attributes for PRKCE Gene

    Size:
    737 amino acids
    Molecular mass:
    83674 Da
    Quaternary structure:
    • Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3. Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner (PubMed:20353823).

    Three dimensional structures from OCA and Proteopedia for PRKCE Gene

neXtProt entry for PRKCE Gene

Selected DME Specific Peptides for PRKCE Gene

Q02156:
  • VNGGDLM
  • RKFDEPR
  • VLGKGSFGKV
  • GKGSFGKV
  • ILKAFMTKN
  • SVDWWALGVLMYEMMAGQPPFEADNED
  • NVAPNCGV
  • DFGMCKE
  • MNVHRRC
  • LSKEAVS
  • YRDLKLDN
  • RQGLQCK
  • VDWWALGVL
  • DRLFFVME
  • CTMTEKR
  • TFCDHCGSLL
  • YAVKVLKKDVILQDDDV
  • FGKVMLAE
  • GTPDYIAPE
  • TFCGTPDYIAPEI
  • YIAPEIL
  • FVMEYVNGG
  • HPFFKEIDW
  • VVHKRCH
  • GAESPQP
  • NGHKFMATYLRQPTYCSHCR
  • FQTKDRL
  • RDLKLDN

Post-translational modifications for PRKCE Gene

  • Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCE (PKCE)

Domains & Families for PRKCE Gene

Gene Families for PRKCE Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02156

UniProtKB/Swiss-Prot:

KPCE_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCE: view

Function for PRKCE Gene

Molecular function for PRKCE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Enzyme Numbers (IUBMB) for PRKCE Gene

Phenotypes From GWAS Catalog for PRKCE Gene

Gene Ontology (GO) - Molecular Function for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 15695813
GO:0004697 protein kinase C activity IDA,TAS --
GO:0004699 calcium-independent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCE: view
genes like me logo Genes that share phenotypes with PRKCE: view

Animal Models for PRKCE Gene

MGI Knock Outs for PRKCE:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCE
  • Applied Biological Materials Clones for PRKCE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCE Gene

Localization for PRKCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCE Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCE gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 5
nucleus 4
cytoskeleton 3
mitochondrion 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 15632189
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 18556656
GO:0005794 colocalizes_with Golgi apparatus ISS,IEA --
genes like me logo Genes that share ontologies with PRKCE: view

Pathways & Interactions for PRKCE Gene

genes like me logo Genes that share pathways with PRKCE: view

Pathways by source for PRKCE Gene

SIGNOR curated interactions for PRKCE Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IEA,IDA 18556656
GO:0006915 apoptotic process TAS 10438519
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PRKCE: view

Drugs & Compounds for PRKCE Gene

(37) Drugs for PRKCE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 399
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 50
KAI-1455 Investigational Pharma activator, Target 0

(12) Additional Compounds for PRKCE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCE Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8

(13) ApexBio Compounds for PRKCE Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
PKC ζ pseudosubstrate
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCE: view

Drug Products

Transcripts for PRKCE Gene

Unigene Clusters for PRKCE Gene

Protein kinase C, epsilon:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCE
  • Applied Biological Materials Clones for PRKCE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4:
SP5:

ExUns: 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PRKCE Gene

GeneLoc Exon Structure for
PRKCE
ECgene alternative splicing isoforms for
PRKCE

Expression for PRKCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCE Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6) and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for PRKCE Gene

This gene is overexpressed in Frontal cortex (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCE Gene



Protein tissue co-expression partners for PRKCE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCE Gene:

PRKCE

SOURCE GeneReport for Unigene cluster for PRKCE Gene:

Hs.580351

Evidence on tissue expression from TISSUES for PRKCE Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRKCE: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCE Gene

Orthologs for PRKCE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCE 34 33
  • 99.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCE 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCE 33 34
  • 93.17 (n)
cow
(Bos Taurus)
Mammalia PRKCE 33 34
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Prkce 16 34 33
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Prkce 33
  • 90.86 (n)
chicken
(Gallus gallus)
Aves PRKCE 34 33
  • 81.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCE 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkce 33
  • 79.25 (n)
Str.13025 33
zebrafish
(Danio rerio)
Actinopterygii prkcea 34
  • 85 (a)
OneToMany
prkceb 33 34
  • 76.34 (n)
Dr.12470 33
fruit fly
(Drosophila melanogaster)
Insecta Pkc98E 35 33 34
  • 60.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002748 33
  • 60.6 (n)
worm
(Caenorhabditis elegans)
Secernentea pkc-1 33 34
  • 58.64 (n)
F48G7.10 35
  • 44 (a)
R12G8.1 35
  • 43 (a)
tpa-1 35
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR191C 33
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 33
  • 49.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06447g 33
  • 49.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06544 33
  • 55.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2703 34
  • 54 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck2 33
  • 50 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9021 33
Species where no ortholog for PRKCE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCE Gene

ENSEMBL:
Gene Tree for PRKCE (if available)
TreeFam:
Gene Tree for PRKCE (if available)

Paralogs for PRKCE Gene

Variants for PRKCE Gene

Sequence variations from dbSNP and Humsavar for PRKCE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs772834505 A colorectal cancer sample 45,976,443(+) ACAAT(A/G)AAGAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000007912 -- 45,892,945(+) CTCCA(C/T)GGGGC intron-variant
rs1000011954 -- 46,117,558(+) AGCCA(A/C)GCTGG intron-variant
rs1000014163 -- 45,914,152(+) AGCAT(A/T)CAATA intron-variant
rs1000022930 -- 45,675,333(+) AACAT(C/G)ATGCT intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRKCE Gene

Variant ID Type Subtype PubMed ID
dgv1119e212 CNV gain 25503493
dgv3804n100 CNV gain 25217958
esv2668866 CNV deletion 23128226
esv2671600 CNV deletion 23128226
esv2674913 CNV deletion 23128226
esv2720010 CNV deletion 23290073
esv2720011 CNV deletion 23290073
esv2720012 CNV deletion 23290073
esv2720013 CNV deletion 23290073
esv2751894 CNV gain 17911159
esv2762545 CNV gain 21179565
esv3096 CNV loss 18987735
esv3305340 CNV mobile element insertion 20981092
esv3338443 CNV insertion 20981092
esv3371820 CNV insertion 20981092
esv3387435 CNV insertion 20981092
esv3400430 CNV insertion 20981092
esv3449017 CNV duplication 20981092
esv3556011 CNV deletion 23714750
esv3556022 CNV deletion 23714750
esv3583778 CNV loss 25503493
esv3590592 CNV loss 21293372
esv3590593 CNV loss 21293372
esv3590595 CNV loss 21293372
esv3590596 CNV loss 21293372
esv3590599 CNV loss 21293372
esv3590600 CNV loss 21293372
esv3892048 CNV loss 25118596
esv9518 CNV loss 19470904
nsv1000736 CNV gain 25217958
nsv1008226 CNV loss 25217958
nsv1009406 CNV loss 25217958
nsv1013787 CNV gain 25217958
nsv1127726 CNV deletion 24896259
nsv213629 CNV deletion 16902084
nsv2713 CNV deletion 18451855
nsv457318 CNV loss 19166990
nsv517015 CNV loss 19592680
nsv518264 CNV loss 19592680
nsv521205 CNV loss 19592680
nsv528112 CNV loss 19592680
nsv581741 CNV gain 21841781
nsv581742 CNV loss 21841781
nsv829130 CNV gain 20364138
nsv829142 CNV gain 20364138
nsv998852 CNV gain 25217958

Variation tolerance for PRKCE Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCE Gene

Disorders for PRKCE Gene

Relevant External Links for PRKCE

Genetic Association Database (GAD)
PRKCE
Human Genome Epidemiology (HuGE) Navigator
PRKCE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCE

No disorders were found for PRKCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKCE Gene

Publications for PRKCE Gene

  1. Sequence and expression of human protein kinase C-epsilon. (PMID: 1382605) Basta P … Burns DJ (Biochimica et biophysica acta 1992) 2 3 4 22 60
  2. Regulation of novel protein kinase C epsilon by phosphorylation. (PMID: 11964154) Cenni V … Toker A (The Biochemical journal 2002) 3 4 22 60
  3. Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function. (PMID: 7877991) Lehel C … Anderson WB (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 22 60
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 3 45 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for PRKCE Gene