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Aliases for PRKCDBP Gene

Aliases for PRKCDBP Gene

  • Protein Kinase C Delta Binding Protein 2 3 5
  • Serum Deprivation Response Factor-Related Gene Product That Binds To C-Kinase 3 4
  • Sdr-Related Gene Product That Binds To C-Kinase 2 3
  • Cavin-3 3 4
  • HSRBC 3 4
  • SRBC 3 4
  • Protein Kinase C, Delta Binding Protein 2
  • Protein Kinase C Delta-Binding Protein 3
  • CAVIN3 3

External Ids for PRKCDBP Gene

Previous GeneCards Identifiers for PRKCDBP Gene

  • GC11M007083
  • GC11M006800
  • GC11M006299
  • GC11M006304
  • GC11M006296
  • GC11M006000

Summaries for PRKCDBP Gene

Entrez Gene Summary for PRKCDBP Gene

  • The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCDBP Gene

PRKCDBP (Protein Kinase C Delta Binding Protein) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12. GO annotations related to this gene include protein kinase C binding. An important paralog of this gene is SDPR.

UniProtKB/Swiss-Prot for PRKCDBP Gene

  • Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCDBP Gene

Genomics for PRKCDBP Gene

Regulatory Elements for PRKCDBP Gene

Enhancers for PRKCDBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F006317 0.4 ENCODE 25.3 -0.3 -258 7.0 TBP PKNOX1 RFX5 RCOR1 ETV6 FOS CREM SMARCC1 USF2 JUNB PRKCDBP OR56A1 TAF10 GC11M006313
GH11F006479 1.1 ENCODE 14.3 -160.8 -160786 3.6 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SP3 PRKCDBP TIMM10B FAM160A2 APBB1 SMPD1 TRIM34 TRIM3
GH11F006458 0.7 ENCODE 14.3 -138.9 -138890 2.4 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SP3 SP5 TIMM10B PRKCDBP ARFIP2 DNHD1 APBB1 SMPD1 GC11P006457 GC11M006470
GH11F006362 1.2 Ensembl ENCODE 11.9 -42.4 -42367 1.6 SCRT1 CTCF ZNF654 MAX REST RAD21 RFX5 SMARCA4 KLF16 SCRT2 PRKCDBP SMPD1 APBB1 OR56A1 GC11P006363
GH11F006703 0.8 ENCODE 11.6 -383.0 -383018 0.2 ELF3 CTCF CEBPG RAD21 RFX5 ZNF366 HSF1 SMC3 HOMEZ DEK MRPL17 PRKCDBP RRP8 GVINP2 GC11P006694 PIR51504
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRKCDBP on UCSC Golden Path with GeneCards custom track

Promoters for PRKCDBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000684744 747 2601 TBP PKNOX1 RFX5 RCOR1 ETV6 FOS CREM SMARCC1 JUNB SMARCA4

Genomic Location for PRKCDBP Gene

Chromosome:
11
Start:
6,318,946 bp from pter
End:
6,320,647 bp from pter
Size:
1,702 bases
Orientation:
Minus strand

Genomic View for PRKCDBP Gene

Genes around PRKCDBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCDBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCDBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCDBP Gene

Proteins for PRKCDBP Gene

  • Protein details for PRKCDBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969G5-PRDBP_HUMAN
    Recommended name:
    Protein kinase C delta-binding protein
    Protein Accession:
    Q969G5

    Protein attributes for PRKCDBP Gene

    Size:
    261 amino acids
    Molecular mass:
    27701 Da
    Quaternary structure:
    • Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.

neXtProt entry for PRKCDBP Gene

Post-translational modifications for PRKCDBP Gene

Other Protein References for PRKCDBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKCDBP

No data available for DME Specific Peptides for PRKCDBP Gene

Domains & Families for PRKCDBP Gene

Gene Families for PRKCDBP Gene

Protein Domains for PRKCDBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCDBP Gene

Graphical View of Domain Structure for InterPro Entry

Q969G5

UniProtKB/Swiss-Prot:

PRDBP_HUMAN :
  • Belongs to the PTRF/SDPR family.
Family:
  • Belongs to the PTRF/SDPR family.
genes like me logo Genes that share domains with PRKCDBP: view

Function for PRKCDBP Gene

Molecular function for PRKCDBP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.
UniProtKB/Swiss-Prot Induction:
Down-regulated in breast and lung cancer cell lines.

Gene Ontology (GO) - Molecular Function for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with PRKCDBP: view
genes like me logo Genes that share phenotypes with PRKCDBP: view

Animal Models for PRKCDBP Gene

MGI Knock Outs for PRKCDBP:

Animal Model Products

miRNA for PRKCDBP Gene

miRTarBase miRNAs that target PRKCDBP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCDBP Gene

Localization for PRKCDBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCDBP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCDBP Gene COMPARTMENTS Subcellular localization image for PRKCDBP gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
GO:0005901 caveola IEA,IDA 24013648
GO:0043234 protein complex IDA 24013648
genes like me logo Genes that share ontologies with PRKCDBP: view

Pathways & Interactions for PRKCDBP Gene

genes like me logo Genes that share pathways with PRKCDBP: view

Pathways by source for PRKCDBP Gene

1 PharmGKB pathway for PRKCDBP Gene

Gene Ontology (GO) - Biological Process for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030866 cortical actin cytoskeleton organization IEA --
GO:0032922 circadian regulation of gene expression IEA,ISS --
GO:0048511 rhythmic process IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with PRKCDBP: view

No data available for SIGNOR curated interactions for PRKCDBP Gene

Drugs & Compounds for PRKCDBP Gene

(124) Additional Compounds for PRKCDBP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with PRKCDBP: view

Transcripts for PRKCDBP Gene

mRNA/cDNA for PRKCDBP Gene

Unigene Clusters for PRKCDBP Gene

Protein kinase C, delta binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCDBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1:
SP2: - -
SP3: - -
SP4: -

Relevant External Links for PRKCDBP Gene

GeneLoc Exon Structure for
PRKCDBP
ECgene alternative splicing isoforms for
PRKCDBP

Expression for PRKCDBP Gene

mRNA expression in normal human tissues for PRKCDBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCDBP Gene

This gene is overexpressed in Artery - Aorta (x5.3), Artery - Coronary (x4.4), and Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for PRKCDBP Gene

This gene is overexpressed in Adipocyte (16.4), Bone marrow stromal cell (15.3), and Uterus (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCDBP Gene



Protein tissue co-expression partners for PRKCDBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCDBP Gene:

PRKCDBP

SOURCE GeneReport for Unigene cluster for PRKCDBP Gene:

Hs.434044

mRNA Expression by UniProt/SwissProt for PRKCDBP Gene:

Q969G5-PRDBP_HUMAN
Tissue specificity: Strongly expressed in mammary and epithelial cells.
genes like me logo Genes that share expression patterns with PRKCDBP: view

Primer Products

Orthologs for PRKCDBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRKCDBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCDBP 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia PRKCDBP 34 35
  • 85.66 (n)
rat
(Rattus norvegicus)
Mammalia Prkcdbp 34
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia PRKCDBP 34 35
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia Prkcdbp 34 16 35
  • 82.94 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKCDBP 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCDBP 35
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCDBP 35
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdprb 35
  • 19 (a)
ManyToMany
sdpra 35
  • 17 (a)
ManyToMany
Species where no ortholog for PRKCDBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRKCDBP Gene

ENSEMBL:
Gene Tree for PRKCDBP (if available)
TreeFam:
Gene Tree for PRKCDBP (if available)

Paralogs for PRKCDBP Gene

Paralogs for PRKCDBP Gene

(2) SIMAP similar genes for PRKCDBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRKCDBP: view

Variants for PRKCDBP Gene

Sequence variations from dbSNP and Humsavar for PRKCDBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10431017 -- 6,322,015(+) ATCTG(C/G)TGATG intron-variant, upstream-variant-2KB
rs1051992 -- 6,319,476(-) GCAGC(C/T)GGAGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10632154 -- 6,321,259(+) TCACC(-/TCT)TCTTT intron-variant, upstream-variant-2KB
rs1063645 -- 6,319,004(-) TGAAA(A/G)AGGTG upstream-variant-2KB, utr-variant-3-prime
rs10839551 -- 6,320,167(+) CTGGG(C/T)TGCGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRKCDBP Gene

Variant ID Type Subtype PubMed ID
nsv1046738 CNV loss 25217958
nsv519454 CNV loss 19592680

Variation tolerance for PRKCDBP Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCDBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCDBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCDBP Gene

Disorders for PRKCDBP Gene

Relevant External Links for PRKCDBP

Genetic Association Database (GAD)
PRKCDBP
Human Genome Epidemiology (HuGE) Navigator
PRKCDBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCDBP

No disorders were found for PRKCDBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKCDBP Gene

Publications for PRKCDBP Gene

  1. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu X.L. … Minna J.D. (Cancer Res. 2001) 3 4 22 64
  2. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y. … Ohno S. (J. Biol. Chem. 1997) 2 3 22 64
  3. Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong S.Y. … Lee S.K. (Acta Obstet Gynecol Scand 2010) 3 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree M.B. … Anand S.S. (Stroke 2009) 3 46 64

Products for PRKCDBP Gene

Sources for PRKCDBP Gene

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