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Aliases for PRKCDBP Gene

Aliases for PRKCDBP Gene

  • Protein Kinase C, Delta Binding Protein 2 3
  • Serum Deprivation Response Factor-Related Gene Product That Binds To C-Kinase 3 4
  • Sdr-Related Gene Product That Binds To C-Kinase 2 3
  • Cavin-3 3 4
  • HSRBC 3 4
  • SRBC 3 4
  • Protein Kinase C Delta-Binding Protein 3
  • CAVIN3 3

External Ids for PRKCDBP Gene

Summaries for PRKCDBP Gene

Entrez Gene Summary for PRKCDBP Gene

  • The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCDBP Gene

PRKCDBP (Protein Kinase C, Delta Binding Protein) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12. GO annotations related to this gene include protein kinase C binding. An important paralog of this gene is PTRF.

UniProtKB/Swiss-Prot for PRKCDBP Gene

  • Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCDBP Gene

Genomics for PRKCDBP Gene

Genomic Location for PRKCDBP Gene

Start:
6,318,946 bp from pter
End:
6,320,647 bp from pter
Size:
1,702 bases
Orientation:
Minus strand

Genomic View for PRKCDBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCDBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCDBP Gene

Regulatory Elements for PRKCDBP Gene

Proteins for PRKCDBP Gene

  • Protein details for PRKCDBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969G5-PRDBP_HUMAN
    Recommended name:
    Protein kinase C delta-binding protein
    Protein Accession:
    Q969G5
    Secondary Accessions:

    Protein attributes for PRKCDBP Gene

    Size:
    261 amino acids
    Molecular mass:
    27701 Da
    Quaternary structure:
    • Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.

neXtProt entry for PRKCDBP Gene

Proteomics data for PRKCDBP Gene at MOPED

Post-translational modifications for PRKCDBP Gene

Other Protein References for PRKCDBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKCDBP Gene

Domains for PRKCDBP Gene

Protein Domains for PRKCDBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRKCDBP Gene

Graphical View of Domain Structure for InterPro Entry

Q969G5

UniProtKB/Swiss-Prot:

PRDBP_HUMAN
Family:
  • Belongs to the PTRF/SDPR family.:
    • Q969G5
genes like me logo Genes that share domains with PRKCDBP: view

No data available for Gene Families for PRKCDBP Gene

Function for PRKCDBP Gene

Molecular function for PRKCDBP Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Seems to have an immune potentiation function.
UniProtKB/Swiss-Prot Induction: Down-regulated in breast and lung cancer cell lines.

Gene Ontology (GO) - Molecular Function for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA --
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with PRKCDBP: view
genes like me logo Genes that share phenotypes with PRKCDBP: view

Animal Models for PRKCDBP Gene

MGI Knock Outs for PRKCDBP:

miRNA for PRKCDBP Gene

miRTarBase miRNAs that target PRKCDBP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKCDBP Gene

Localization for PRKCDBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCDBP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCDBP Gene COMPARTMENTS Subcellular localization image for PRKCDBP gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005901 caveola IDA 24013648
GO:0043234 protein complex IDA 24013648
genes like me logo Genes that share ontologies with PRKCDBP: view

Pathways for PRKCDBP Gene

genes like me logo Genes that share pathways with PRKCDBP: view

Pathways by source for PRKCDBP Gene

1 PharmGKB pathway for PRKCDBP Gene

Gene Ontology (GO) - Biological Process for PRKCDBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030866 cortical actin cytoskeleton organization IEA --
GO:0032922 circadian regulation of gene expression ISS --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
GO:1901003 negative regulation of fermentation IEA --
genes like me logo Genes that share ontologies with PRKCDBP: view

Compounds for PRKCDBP Gene

(124) HMDB Compounds for PRKCDBP Gene

Compound Synonyms Cas Number PubMed IDs
PS(14:0/14:0)
  • Phosphatidylserine(14:0/14:0)
Not Available
PS(14:0/14:1(9Z))
  • Phosphatidylserine(14:0/14:1n5)
Not Available
PS(14:0/16:0)
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
PS(14:0/16:1(9Z))
  • PS(14:0/16:1n7)
Not Available
PS(14:0/18:0)
  • Phosphatidylserine(32:0)
Not Available
genes like me logo Genes that share compounds with PRKCDBP: view

Transcripts for PRKCDBP Gene

mRNA/cDNA for PRKCDBP Gene

Unigene Clusters for PRKCDBP Gene

Protein kinase C, delta binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCDBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1:
SP2: - -
SP3: - -
SP4: -

Relevant External Links for PRKCDBP Gene

GeneLoc Exon Structure for
PRKCDBP
ECgene alternative splicing isoforms for
PRKCDBP

Expression for PRKCDBP Gene

mRNA expression in normal human tissues for PRKCDBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCDBP Gene

This gene is overexpressed in Artery - Aorta (5.3), Artery - Coronary (4.4), and Artery - Tibial (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCDBP Gene

SOURCE GeneReport for Unigene cluster for PRKCDBP Gene Hs.434044

mRNA Expression by UniProt/SwissProt for PRKCDBP Gene

Q969G5-PRDBP_HUMAN
Tissue specificity: Strongly expressed in mammary and epithelial cells.
genes like me logo Genes that share expressions with PRKCDBP: view

Orthologs for PRKCDBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRKCDBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCDBP 35
  • 99.74 (n)
  • 99.62 (a)
PRKCDBP 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCDBP 35
  • 85.66 (n)
  • 86.43 (a)
PRKCDBP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCDBP 35
  • 83.91 (n)
  • 81.23 (a)
PRKCDBP 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcdbp 35
  • 82.94 (n)
  • 83.33 (a)
Prkcdbp 16
Prkcdbp 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCDBP 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcdbp 35
  • 84.58 (n)
  • 85.49 (a)
chicken
(Gallus gallus)
Aves PRKCDBP 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCDBP 36
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdpra 36
  • 17 (a)
ManyToMany
sdprb 36
  • 19 (a)
ManyToMany
Species with no ortholog for PRKCDBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRKCDBP Gene

ENSEMBL:
Gene Tree for PRKCDBP (if available)
TreeFam:
Gene Tree for PRKCDBP (if available)

Paralogs for PRKCDBP Gene

Paralogs for PRKCDBP Gene

Selected SIMAP similar genes for PRKCDBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRKCDBP: view

Variants for PRKCDBP Gene

Sequence variations from dbSNP and Humsavar for PRKCDBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12570 -- 6,319,295(-) AGCGC(A/T)GAAGC synonymous-codon, reference
rs1051992 - 6,319,476(-) GCAGC(C/T)GGAGG missense, reference
rs1063645 -- 6,319,004(-) TGAAA(A/G)AGGTG utr-variant-3-prime
rs1159430 -- 6,318,794(-) TCCTT(C/T)TGACC downstream-variant-500B
rs1159431 -- 6,318,754(-) AACAC(A/G)CAGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRKCDBP Gene

Variant ID Type Subtype PubMed ID
nsv519454 CNV Loss 19592680

Relevant External Links for PRKCDBP Gene

HapMap Linkage Disequilibrium report
PRKCDBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCDBP Gene

Disorders for PRKCDBP Gene

Relevant External Links for PRKCDBP

Genetic Association Database (GAD)
PRKCDBP
Human Genome Epidemiology (HuGE) Navigator
PRKCDBP
genes like me logo Genes that share disorders with PRKCDBP: view

No data available for UniProtKB/Swiss-Prot for PRKCDBP Gene

Publications for PRKCDBP Gene

  1. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y. … Ohno S. (J. Biol. Chem. 1997) 2 3 23
  2. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu X.L. … Minna J.D. (Cancer Res. 2001) 3 4 23
  3. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. (PMID: 15940253) ZAPchbauer-MA1ller S. … Minna J.D. (Oncogene 2005) 3 23
  4. Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong S.Y. … Lee S.K. (Acta Obstet Gynecol Scand 2010) 3 23
  5. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree M.B. … Anand S.S. (Stroke 2009) 3 48

Products for PRKCDBP Gene

Sources for PRKCDBP Gene

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