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PRKCD Gene

protein-coding   GIFtS: 75
GCID: GC03P053190

Protein Kinase C, Delta

  See PRKCD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Delta1 2     PKCD2
Tyrosine-Protein Kinase PRKCD2 3     Protein Kinase C Delta Type2
nPKC-delta2 3     Protein Kinase C Delta VIII2
EC 2.7.11.133 8     EC 2.7.10.23
CVID92 5     EC 2.7.118
MAY12     

External Ids:    HGNC: 93991   Entrez Gene: 55802   Ensembl: ENSG000001639327   OMIM: 1769775   UniProtKB: Q056553   

Export aliases for PRKCD gene to outside databases

Previous GC identifers: GC03P052287 GC03P052446 GC03P053050 GC03P053152 GC03P053170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCD Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of
the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell
signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types.
Alternatively spliced transcript variants encoding the same protein have been observed. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRKCD Gene:
PRKCD (protein kinase C, delta) is a protein-coding gene. Diseases associated with PRKCD include immunodeficiency, common variable, 9, and autoimmune lymphoproliferative syndrome, type ib. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death,
is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical
production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA
damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated
p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA
in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced
apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of
p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the
level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation
of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators
BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for
degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell
cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition
of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin
CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M
DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably
by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of
cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1
(CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and
MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In
N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and
activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by
direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also
play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4
or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin
polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates
MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit
phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)

summary for PRKCD Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCD gene promoter:
         p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCD promoter sequence
   Search Chromatin IP Primers for PRKCD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

PRKCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053190:  view genomic region     (about GC identifiers)

Start:
53,190,025 bp from pter      End:
53,226,733 bp from pter
Size:
36,709 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655 (See protein sequence)
Recommended Name: Protein kinase C delta type  
Size: 676 amino acids; 77505 Da
Subunit: Interacts with PDPK1 (via N-terminus region), RAD9A, CDCP1, MUC1 and VASP
2 PDB 3D structures from and Proteopedia for PRKCD:
1YRK (3D)        2YUU (3D)    
Secondary accessions: B0KZ81 B2R834 Q15144 Q86XJ6
Alternative splicing: 2 isoforms:  Q05655-1   Q05655-2   (Antiapoptotic isoform, resistant to caspase-3 cleavage)

Explore the universe of human proteins at neXtProt for PRKCD: NX_Q05655

Explore proteomics data for PRKCD at MOPED

Post-translational modifications: 

  • Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not
    a prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL
    treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic
    reticulum and cleavage by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313
    and Tyr-567 following thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase
    PDPK1; phosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN21
  • Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which
    results in kinase activation (By similarity)1
  • Ubiquitination2 at Lys184, Lys362, Lys613
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCD (Q05655) (see all 24)
     GVLLYEM  DFGMCKE  YIAPEIL  GQSPFHG 


    See PRKCD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006245.2  NP_997704.1  

    ENSEMBL proteins: 
     ENSP00000419726   ENSP00000378217   ENSP00000331602   ENSP00000418106   ENSP00000419629  
    Reactome Protein details: Q05655

    PRKCD Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCD Protein
    R&D Systems Recombinant & Natural Proteins for PRKCD (PKC delta)
    Enzo Life Sciences proteins for PRKCD
    OriGene Purified Protein for PRKCD
    OriGene Protein Over-expression Lysate for PRKCD
    OriGene MassSpec for PRKCD
    OriGene Custom Protein Services for PRKCD
    GenScript Custom Purified and Recombinant Proteins Services for PRKCD
    Novus Biologicals PRKCD Proteins
    Novus Biologicals PRKCD Lysates
    Sino Biological Recombinant Protein for PRKCD
    Sino Biological Cell Lysate for PRKCD
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCD 

     
    antibodies-online proteins for PRKCD (18 products) 

     
    antibodies-online peptides for PRKCD

    PRKCD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
    R&D Systems Antibodies for PRKCD (PKC delta)
    Cell Signaling Technology (CST) Antibodies for PRKCD  (PKCD)
    OriGene Antibodies for PRKCD
    OriGene Custom Antibody Services for PRKCD
    Novus Biologicals PRKCD Antibodies
    Abcam antibodies for PRKCD
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKCD
    antibodies-online antibodies for PRKCD (253 products) 

    PRKCD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKCD 
    antibodies-online kits for PRKCD (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, delta
    Delta subfamily
    Protein kinase C

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR014376 Prot_kin_PKC_delta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05655

    ProtoNet protein and cluster: Q05655

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
    Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol
    sensor
    Domain: The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a
    sequence-specific manner
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCD_HUMAN, Q05655
    Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
    that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
    damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death,
    is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical
    production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA
    damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated
    p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA
    in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced
    apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of
    p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the
    level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation
    of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators
    BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for
    degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell
    cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition
    of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin
    CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M
    DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably
    by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of
    cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1
    (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and
    MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In
    N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and
    activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by
    direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also
    play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4
    or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin
    polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
    CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
    PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates
    MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit
    phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by
    diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-507 (activation loop of the kinase
    domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full
    activation. Activated by caspase-3 (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif
    in the regulatory subunit is released from the substrate recognition site of the catalytic subunit, which enables
    PRKCD to become constitutively activated. The catalytic subunit which displays properties of a
    sphingosine-dependent protein kinase is activated by D-erythro-sphingosine (Sph) or
    N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS), but not by ceramide or
    Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity)

         Genatlas biochemistry entry for PRKCD:
    protein kinase C,delta polypeptide,involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain
    shedding upon TPA stimulation

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112 EC 2.7.10.21

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10770950
    GO:0004697protein kinase C activity ISS--
    GO:0004699calcium-independent protein kinase C activity TAS14583092
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with PRKCD           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRKCD:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased apoptosis 
     Increased cell death HMECs cel  Increased viability with TRAIL 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prkcd):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  renal/urinary system  skeleton 

    Find genes that share phenotypes with PRKCD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKCD: Prkcdtm1Kin Prkcdtm1Msg

       genOway: Develop your customized and physiologically relevant rodent model for PRKCD

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKCD:
    hsa-mir-615-3p (MIRT039609), hsa-mir-484 (MIRT041814)

    Block miRNA regulation of human, mouse, rat PRKCD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRKCD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKCD
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCD

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCD (see all 14)
    OriGene ORF clones in mouse, rat for PRKCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
    Sino Biological Human cDNA Clone for PRKCD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
    Addgene plasmids for PRKCD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCD
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKCD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12074) for PRKCD 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCD_HUMAN, Q05655: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion.
    Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15632189
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA15632189
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IDA15774464

    Find genes that share ontologies with PRKCD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for PRKCD About   (see all 121)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38
    3ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    4G Protein Signaling Pathways
    G Protein Signaling Pathways0.44
    Signal transduction cAMP signaling0.44
    5Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43


    Find genes that share SuperPaths with PRKCD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for PRKCD
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCD (see all 84)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCD
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCD
        NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCD (see all 22)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development FGF-family signaling
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2

    Selected BioSystems Pathways for PRKCD (see all 39)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    Wnt Signaling Pathway
    Insulin Signaling
    Wnt Signaling Pathway and Pluripotency

    5 Sino Biological Pathways for PRKCD
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    VEGF Signaling
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for PRKCD (see all 8)
        Effects of PIP2 hydrolysis
    Interferon gamma signaling
    Apoptotic cleavage of cellular proteins
    DAG and IP3 signaling
    Calmodulin induced events

    2 PharmGKB Pathways for PRKCD
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCD) (see all 10):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    Tight junction
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCD: 
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              Alzheimer's Disease in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCD (Q056551, 2, 3 ENSP000003316024) via UniProtKB, MINT, STRING, and/or I2D (see all 328)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1Q9H5V82, 3, ENSP000002961294MINT-62341 MINT-62334 MINT-62336 MINT-62333 MINT-62332 MINT-62339 I2D: score=3 STRING: ENSP00000296129
    DIABLOQ9NR281, 2EBI-704279,EBI-517508 MINT-8328987 MINT-8329313 MINT-8328976 MINT-8329001
    NCF1P145982, 3, ENSP000002894734MINT-3973536 I2D: score=2 STRING: ENSP00000289473
    PPM1AP358132, 3, ENSP000003272554MINT-8387176 I2D: score=2 STRING: ENSP00000327255
    ABL1P005192, 3, ENSP000003614234MINT-1955124 I2D: score=1 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 65):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ----
    GO:0006468protein phosphorylation IDA16611985
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with PRKCD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKCD
    10 ApexBio Compounds for PRKCD     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCD (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    2 DrugBank Compounds for PRKCD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    13-Acetylphorbol-- --target--10592235
    Ingenol Mebutate 3-Ingenyl Angelate (see all 4)75567-37-2targetligand15126366

    Selected Novoseek inferred chemical compound relationships for PRKCD gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rottlerin 96.1 34 17133362 (2), 17927688 (2), 10618482 (1), 16698440 (1) (see all 29)
    n-benzyladriamycin-14-valerate 82.7 1 11297449 (1)
    nsc-606985 82.6 2 19747914 (1), 19322780 (1)
    pkcs 82.5 2 20236250 (1), 16424000 (1)
    bryostatin 1 70.4 6 10194341 (2), 8077702 (1), 10626804 (1), 14725904 (1)
    phorbol 61.3 5 10713064 (1), 11595128 (1), 16183650 (1), 10818086 (1) (see all 5)
    tyrosine 60.6 36 7568083 (4), 10698304 (2), 15811957 (1), 11381116 (1) (see all 29)
    12-o-tetradecanoylphorbol 13-acetate 55.1 6 7830075 (2), 17964626 (1)
    phosphatidylinositol 48.6 5 11549843 (1), 8663229 (1), 11912175 (1), 19074768 (1) (see all 5)
    serine 48.5 4 11438522 (1), 9857052 (1), 9305920 (1), 16424000 (1)



    Find genes that share compounds with PRKCD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKCD gene (2 alternative transcripts): 
    NM_006254.3  NM_212539.1  

    Unigene Cluster for PRKCD:

    Protein kinase C, delta
    Hs.155342  [show with all ESTs]
    Unigene Representative Sequence: NM_006254
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478843 ENST00000394729(uc003dgl.3 uc003dgm.3) ENST00000330452(uc010hmt.1)
    ENST00000477794 ENST00000487897 ENST00000464818(uc003dgn.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRKCD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRKCD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRKCD
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCD
    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCD (see all 14)
    OriGene ORF clones in mouse, rat for PRKCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
    Addgene plasmids for PRKCD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRKCD
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKCD
      QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
      QuantiFast Probe-based Assays in human, mouse, rat PRKCD
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12074) for PRKCD 

    Additional mRNA sequence: 

    AK130150.1 AK294272.1 AK313216.1 BC043350.1 BC127261.1 D10495.1 DQ516383.1 L07860.1 
    L07861.1 Z22521.1 

    8 DOTS entries:

    DT.447562  DT.92327244  DT.100008116  DT.95092309  DT.100026851  DT.120850705  DT.91834194  DT.91713047 

    Selected AceView cDNA sequences (see all 254):

    AI127149 BM975717 BI858343 AA310139 BF446886 CF141981 BF446364 CR596063 
    AI312882 NM_006254 BF445845 BQ086286 BQ706214 AI126073 BF939213 BP336675 
    BX378948 BQ712651 CK822956 NM_212539 CD518507 CA454205 AW196443 BM967192 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                    -                                   -                                                           -                                       
    SP2:              -     -                                   -                                                           -                                       
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PRKCD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGACTGGT
    PRKCD Expression
    About this image


    PRKCD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Spinous Keratinocytes Stratified Epidermis
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PRKCD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155342
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCD: 
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              Alzheimer's Disease in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRKCD
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKCD
    QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
    QuantiFast Probe-based Assays in human, mouse, rat PRKCD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCD gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcd1 , 5 protein kinase C, delta1, 5 87.27(n)1
    90.79(a)1
      14 (18.82 cM)5
    187531  NM_011103.31  NP_035233.11 
     305953585 
    chicken
    (Gallus gallus)
    Aves PRKCD1 protein kinase C, delta 76.93(n)
    85.57(a)
      415905  NM_001006133.1  NP_001006133.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCD6
    protein kinase C, delta
    83(a)
    1 ↔ 1
    2(155711970-155751256)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB109739.12   -- 79.63(n)    AB109739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb09d102 Danio rerio mRNA similar to protein kinase C, delta (cDNA clone MGC56558 IMAGE5914672), complete cds less 75.7(n)    BC049327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc&dgr;3
    Pkcdelta1
    protein amino acid phosphorylation
    protein serine/threonine kinase less3
    Protein kinase C delta1
    55(a)3
    60.22(n)1
    57.47(a)1
      321911  NM_078616.31  NP_511171.31 
    worm
    (Caenorhabditis elegans)
    Secernentea tpa-11 , 3 protein kinase C3
    tpa-11
    48(a)
    (best of 3)3
    55.4(n)1
    51.26(a)1
      IV(92052-110151)3
    1768251  NM_067459.31  NP_499860.11 


    ENSEMBL Gene Tree for PRKCD (if available)
    TreeFam Gene Tree for PRKCD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCD gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  
    PKN32  PRKCG2  PKN22  
    15 SIMAP similar genes for PRKCD using alignment to 4 protein entries:     KPCD_HUMAN (see all proteins):
    PRKCQ    PKN2    AKT2    PRKCH    AKT3    PKN3
    PRKCE    PRKCI    AKT1    PKN1    PRKD1    PRKCZ
    PRKCA    PRKCG    PRKCB

    Find genes that share paralogs with PRKCD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCD (see all 1266)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898387511,2
    C--53195185(+) CGGGGC/TCGGCG 2 -- us2k10--------
    rs1822467851,2
    --53195611(+) CTGTCC/TGTCTG 2 -- int10--------
    rs1139945381,2
    F--53195648(+) CTGAGG/CTCCTT 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1451498211,2
    --53195764(+) TGTCGC/TCACCC 2 -- int10--------
    rs1145454421,2
    C,F--53195771(+) ACCCAC/TTCTGT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs799031211,2
    C,F--53196008(+) CCGCCC/TGCCGG 2 -- int11Minor allele frequency- T:0.50NA 2
    rs3777294241,2
    C--53196215(+) CCGATA/GGGTCT 2 -- int10--------
    rs93114891,2
    C,A--53196288(+) GGTCGC/GGGGGG 2 -- int1 trp33Minor allele frequency- G:0.29NA 124
    rs93114901,2
    C--53196361(+) CCCCAA/GTTCCC 2 -- int113Minor allele frequency- G:0.02NA WA CSA EA 375
    rs1868453961,2
    --53196400(+) CGAGCC/TCCGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRKCD (53190025 - 53226733 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRKCD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv460554CNV Loss19166990
    nsv834699CNV Loss17160897
    nsv470583CNV Loss18288195
    nsv517233CNV Loss19592680
    nsv460553CNV Loss19166990

    Human Gene Mutation Database (HGMD): PRKCD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCD
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176977   
    OMIM disorders: 615559  
    5 diseases for PRKCD:    
    About MalaCards
    immunodeficiency, common variable, 9    autoimmune lymphoproliferative syndrome, type ib    systemic lupus erythematosus 16    common variable immune deficiency
    acth-secreting pituitary adenoma


    Find genes that share disorders with PRKCD           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKCD gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 27.2 6 19965895 (1), 8848016 (1), 15135084 (1), 19169273 (1) (see all 6)
    tumors 22.4 19 11470753 (2), 8999887 (1), 15386430 (1), 18653803 (1) (see all 16)
    colon cancer 15.4 3 15386430 (1), 15494216 (1), 18807195 (1)
    mammary tumor 6.55 1 10597283 (1)
    parkinson disease 4.59 3 15961393 (1), 18945348 (1), 19633700 (1)
    breast cancer 1.43 4 11595128 (1), 10221776 (1), 16617167 (1), 19903772 (1)
    adenocarcinoma lung 0.901 1 12525155 (1)
    gastric carcinoma 0.758 1 16598791 (1)
    carcinoma squamous cell 0 4 20093486 (2), 16158048 (1), 16424000 (1)
    ischemia 0 2 15167677 (1), 16111715 (1)

    Genetic Association Database (GAD): PRKCD
    Human Genome Epidemiology (HuGE) Navigator: PRKCD (6 documents)

    Export disorders for PRKCD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCD gene, integrated from 10 sources (see all 769):
    (articles sorted by number of sources associating them with PRKCD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. (PubMed id 8188219)1, 3, 9 Huppi K....Mischak H. (Genomics 1994)
    2. Novel phosphorylation site markers of protein kinase C delta activation. (PubMed id 17603046)1, 2, 9 Durgan J.... Parker P.J. (FEBS Lett. 2007)
    3. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. (PubMed id 11877440)1, 2, 9 Ren J.... Kufe D. (J. Biol. Chem. 2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC. (PubMed id 19801500)1, 2 Kilpatrick L.E.... Korchak H.M. (J. Leukoc. Biol. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    8. Identification of a novel antiapoptotic human protein kinase C delta isoform, PKCdeltaVIII in NT2 cells. (PubMed id 18092819)1, 2 Jiang K.... Patel N.A. (Biochemistry 2008)
    9. The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. (PubMed id 17579121)1, 2 Gomel R....Brodie C. (Mol. Cancer Res. 2007)
    10. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5580 HGNC: 9399 AceView: PRKCD Ensembl:ENSG00000163932 euGenes: HUgn5580
    ECgene: PRKCD Kegg: 5580 H-InvDB: PRKCD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKCD gene:
    Search GeneIP for patents involving PRKCD

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

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     Browse Kits and Assays available from EMD Millipore
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
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     Block miRNA regulation of human, mouse, rat PRKCD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRKCD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCD Predesigned siRNA for gene silencing in human, mouse, rat PRKCD
     QuantiFast Probe-based Assays in human, mouse, rat PRKCD QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
     PCR Arrays including human, mouse, rat PRKCD Search Chromatin IP Primers for PRKCD
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     GenScript Custom Purified and Recombinant Proteins Services for PRKCD GenScript cDNA clones with any tag delivered in your preferred vector for PRKCD
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for PRKCD  (PKCD)

     Tocris compounds for PRKCD
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRKCD antibodies
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     See all of Abcam's Antibodies, Kits and Proteins for PRKCD
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRKCD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD
     SwitchGear 3'UTR luciferase reporter plasmids for PRKCD
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
     ApexBio compounds for PRKCD
     Addgene plasmids for PRKCD
      Search eBioscience for proteins for PRKCD
      Search eBioscience for elisas for PRKCD
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PRKCD
     antibodies-online antibodies for PRKCD (253 products)
     antibodies-online kits for PRKCD (37 products)
     antibodies-online peptides for PRKCD
     antibodies-online proteins for PRKCD (18 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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