Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCD Gene

protein-coding   GIFtS: 75
GCID: GC03P053190

Protein Kinase C, Delta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase C, Delta1 2     PKCD2
Tyrosine-Protein Kinase PRKCD2 3     Protein Kinase C Delta Type2
nPKC-delta2 3     Protein Kinase C Delta VIII2
EC 2.7.11.133 8     EC 2.7.10.23
MAY12     EC 2.7.118

External Ids:    HGNC: 93991   Entrez Gene: 55802   Ensembl: ENSG000001639327   OMIM: 1769775   UniProtKB: Q056553   

Export aliases for PRKCD gene to outside databases

Previous GC identifers: GC03P052287 GC03P052446 GC03P053050 GC03P053152 GC03P053170


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKCD Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of
the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell
signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types.
Alternatively spliced transcript variants encoding the same protein have been observed. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRKCD Gene: 
PRKCD (protein kinase C, delta) is a protein-coding gene. Diseases associated with PRKCD include pneumonic plague, and plague, and among its related super-pathways are DAG and IP3 signaling and fMLP Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and enzyme binding. An important paralog of this gene is ENSG00000258989.

UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death,
is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical
production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA
damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated
p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA
in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced
apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of
p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the
level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation
of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators
BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for
degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell
cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition
of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin
CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M
DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably
by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of
cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1
(CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and
MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In
N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and
activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by
direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also
play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4
or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin
polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates
MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit
phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)

summary for PRKCD Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCD gene promoter:
         p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCD promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

PRKCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053190:  view genomic region     (about GC identifiers)

Start:
53,190,025 bp from pter      End:
53,226,733 bp from pter
Size:
36,709 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655 (See protein sequence)
Recommended Name: Protein kinase C delta type  
Size: 676 amino acids; 77505 Da
Subunit: Interacts with PDPK1 (via N-terminus region), RAD9A, CDCP1, MUC1 and VASP
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion.
Cell membrane; Peripheral membrane protein
2 PDB 3D structures from and Proteopedia for PRKCD:
1YRK (3D)        2YUU (3D)    
Secondary accessions: B0KZ81 B2R834 Q15144 Q86XJ6
Alternative splicing: 2 isoforms:  Q05655-1   Q05655-2   (Antiapoptotic isoform, resistant to caspase-3 cleavage)

Explore the universe of human proteins at neXtProt for PRKCD: NX_Q05655

Explore proteomics data for PRKCD at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not
    a prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL
    treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic
    reticulum and cleavage by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313
    and Tyr-567 following thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase
    PDPK1; phosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2
  • UniProtKB: Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which
    results in kinase activation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05655

  • 4/24 DME Specific Peptides for PRKCD (Q05655) (see all 24)
     GVLLYEM  DFGMCKE  YIAPEIL  GQSPFHG 

    PRKCD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKCD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006245.2  NP_997704.1  

    ENSEMBL proteins: 
     ENSP00000419726   ENSP00000378217   ENSP00000331602   ENSP00000418106   ENSP00000419629  
    Reactome Protein details: Q05655
    Human Recombinant Protein Products for PRKCD: 
    EMD Millipore Purified and/or Recombinant PRKCD Protein
    R&D Systems Recombinant & Natural Proteins for PRKCD (PKC delta)
    Enzo Life Sciences proteins for PRKCD
    OriGene Purified Protein for PRKCD
    OriGene Protein Over-expression Lysate for PRKCD
    OriGene MassSpec for PRKCD 
    OriGene Custom Protein Services for PRKCD
    GenScript Custom Purified and Recombinant Proteins Services for PRKCD
    Novus Biologicals PRKCD Proteins
    Novus Biologicals PRKCD Lysates
    Sino Biological Recombinant Protein for PRKCD
    Sino Biological Cell Lysate for PRKCD 
    ProSpec Recombinant Protein for PRKCD
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15632189
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IDA15774464

    PRKCD for ontologies           About GeneDecksing



    PRKCD Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
    R&D Systems Antibodies for PRKCD (PKC delta)
    Cell Signaling Technology (CST) Antibodies for PRKCD  (PKCD)
    OriGene Antibodies for PRKCD
    OriGene Custom Antibody Services for PRKCD
    GenScript Superior Antibodies for PRKCD
    Novus Biologicals PRKCD Antibodies
    Abcam antibodies for PRKCD
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PRKCD
    LSBio Antibodies in human, mouse, rat for PRKCD 

    Assay Products for PRKCD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKCD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, delta 
    Delta subfamily
    Protein kinase C

    5/13 InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR014376 Prot_kin_PKC_delta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05655

    ProtoNet protein and cluster: Q05655

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
    Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol
    sensor
    Domain: The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a
    sequence-specific manner
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    PRKCD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCD_HUMAN, Q05655
    Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
    that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
    damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death,
    is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical
    production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA
    damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated
    p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA
    in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced
    apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of
    p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the
    level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation
    of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators
    BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for
    degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell
    cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition
    of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin
    CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M
    DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably
    by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of
    cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1
    (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and
    MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In
    N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and
    activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by
    direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also
    play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4
    or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin
    polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
    CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
    PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates
    MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit
    phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by
    diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-507 (activation loop of the kinase
    domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full
    activation. Activated by caspase-3 (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif
    in the regulatory subunit is released from the substrate recognition site of the catalytic subunit, which enables
    PRKCD to become constitutively activated. The catalytic subunit which displays properties of a
    sphingosine-dependent protein kinase is activated by D-erythro-sphingosine (Sph) or
    N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS), but not by ceramide or
    Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity)

         Genatlas biochemistry entry for PRKCD:
    protein kinase C,delta polypeptide,involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain
    shedding upon TPA stimulation

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112 EC 2.7.10.21

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10770950
    GO:0004697protein kinase C activity ISS--
    GO:0004699calcium-independent protein kinase C activity TAS14583092
    GO:0004713protein tyrosine kinase activity ----
         
    PRKCD for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRKCD:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased apoptosis 
     Increased cell death HMECs cel  Increased viability with TRAIL 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prkcd):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  renal/urinary system  skeleton 

    PRKCD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKCD: Prkcdtm1Kin Prkcdtm1Msg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKCD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKCD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCD
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRKCD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRKCD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCD
    Sirion Biotech Customized adenovirus for overexpression of PRKCD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRKCD (see all 15)
    OriGene ORF clones in mouse, rat for PRKCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
    Sino Biological Human cDNA Clone for PRKCD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
    Sirion Biotech Customized lentivirus for stable overexpression of PRKCD 
                         Customized lentivirus expression plasmids for stable overexpression of PRKCD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCD
    Search LifeMap BioReagents cell lines for PRKCD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKCD About   (see all 123)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    2fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    3Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    4Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.75
    VEGF - VEGF R2 Signaling Pathways 0.39
    Development VEGF signaling and activation0.75
    5Development FGF-family signaling
    Development FGF-family signaling0.63
    FGF Pathway0.38
    Development FGFR signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for PRKCD (see all 22)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Development A1 receptor signaling

    4 R&D Systems Pathways for PRKCD
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    5/84 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCD (see all 84)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCD
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCD
        NF-kappaB Pathway
    VEGF Pathway

    5/22 GeneGo (Thomson Reuters) Pathways for PRKCD (see all 22)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development FGF-family signaling
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2

    5/38 BioSystems Pathways for PRKCD (see all 38)
        MAPK signaling pathway
    Myometrial Relaxation and Contraction Pathways
    Wnt Signaling Pathway
    Insulin Signaling
    Wnt Signaling Pathway and Pluripotency

    5 Sino Biological Pathways for PRKCD 
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    VEGF Signaling
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    5/48        Reactome Pathways for PRKCD (see all 48)
        Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Stabilization of mRNA by HuR
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for PRKCD
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/9         Kegg Pathways  (Kegg details for PRKCD) (see all 9):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    Tight junction
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis


    PRKCD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/248 Interacting proteins for PRKCD (Q056551, 2, 3 ENSP000003316024) via UniProtKB, MINT, STRING, and/or I2D (see all 248)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1Q9H5V82, 3, ENSP000002961294MINT-62341 MINT-62334 MINT-62336 MINT-62333 MINT-62332 MINT-62339 I2D: score=3 STRING: ENSP00000296129
    NCF1P145982, 3, ENSP000002894734MINT-3973536 I2D: score=2 STRING: ENSP00000289473
    PPM1AP358132, 3, ENSP000003272554MINT-8387176 I2D: score=2 STRING: ENSP00000327255
    ABL1P005192, 3, ENSP000003614234MINT-1955124 I2D: score=1 STRING: ENSP00000361423
    SRCP129312, 3, ENSP000003509414MINT-62340 MINT-62338 I2D: score=3 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5/67 biological process terms (GO ID links to tree view) (see all 67):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006468protein phosphorylation IDA16611985
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006979response to oxidative stress ----

    PRKCD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCD for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCD:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCD

    Compounds for PRKCD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    10/846 HMDB Compounds for PRKCD (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    2 DrugBank Compounds for PRKCD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    13-Acetylphorbol-- --target--10592235
    Ingenol Mebutate 3-Ingenyl Angelate (see all 4)75567-37-2targetligand15126366

    10/44 Novoseek inferred chemical compound relationships for PRKCD gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rottlerin 96.1 34 17133362 (2), 17927688 (2), 10618482 (1), 16698440 (1) (see all 29)
    n-benzyladriamycin-14-valerate 82.7 1 11297449 (1)
    nsc-606985 82.6 2 19747914 (1), 19322780 (1)
    pkcs 82.5 2 20236250 (1), 16424000 (1)
    bryostatin 1 70.4 6 10194341 (2), 8077702 (1), 10626804 (1), 14725904 (1)
    phorbol 61.3 5 10713064 (1), 11595128 (1), 16183650 (1), 10818086 (1) (see all 5)
    tyrosine 60.6 36 7568083 (4), 10698304 (2), 15811957 (1), 11381116 (1) (see all 29)
    12-o-tetradecanoylphorbol 13-acetate 55.1 6 7830075 (2), 17964626 (1)
    phosphatidylinositol 48.6 5 11549843 (1), 8663229 (1), 11912175 (1), 19074768 (1) (see all 5)
    serine 48.5 4 11438522 (1), 9857052 (1), 9305920 (1), 16424000 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCD / KPCD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKCD gene (2 alternative transcripts): 
    NM_006254.3  NM_212539.1  

    Unigene Cluster for PRKCD:

    Protein kinase C, delta
    Hs.155342  [show with all ESTs]
    Unigene Representative Sequence: NM_006254
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478843 ENST00000394729(uc003dgl.3 uc003dgm.3) ENST00000330452(uc010hmt.1)
    ENST00000477794 ENST00000487897 ENST00000464818(uc003dgn.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCD
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidPRKCD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRKCD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCD
    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCD (see all 15)
    OriGene ORF clones in mouse, rat for PRKCD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
    Sirion Biotech Customized lentivirus for stable overexpression of PRKCD 
                         Customized lentivirus expression plasmids for stable overexpression of PRKCD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRKCD
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCD

    Additional mRNA sequence: 

    AK130150.1 AK294272.1 AK313216.1 BC043350.1 BC127261.1 D10495.1 DQ516383.1 L07860.1 
    L07861.1 Z22521.1 

    8 DOTS entries:

    DT.447562  DT.92327244  DT.100008116  DT.95092309  DT.100026851  DT.120850705  DT.91834194  DT.91713047 

    24/254 AceView cDNA sequences (see all 254):

    BM975717 CA454205 BI858343 BF446364 NM_006254 NM_212539 CK822956 BM967192 
    CR596063 BF446886 AI312882 CD518507 AA310139 BQ706214 AW196443 BX378948 
    AI126073 BQ712651 BM755813 BF445845 BQ086286 AI127149 BE889730 BF939213 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                    -                                   -                                                           -                                       
    SP2:              -     -                                   -                                                           -                                       
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PRKCD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCD expression in normal human tissues (normalized intensities)      PRKCD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGACTGGT
    PRKCD Expression
    About this image


    PRKCD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PRKCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCD

    SOURCE GeneReport for Unigene cluster: Hs.155342
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCD: 
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              Alzheimer's Disease in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRKCD
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PRKCD gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcd1 , 5 protein kinase C, delta1, 5 87.32(n)1
    90.79(a)1
      14 (18.82 cM)5
    187531  NM_011103.31  NP_035233.11 
     305953585 
    chicken
    (Gallus gallus)
    Aves PRKCD1 protein kinase C, delta 76.88(n)
    85.57(a)
      415905  NM_001006133.1  NP_001006133.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCD6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    2(155711970-155751256)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB109739.12   -- 79.63(n)    AB109739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb09d102 Danio rerio mRNA similar to protein kinase C, delta more 75.7(n)    BC049327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc&dgr;3
    Pkcdelta1
    protein amino acid phosphorylation
    protein serine/threonine more3
    Protein kinase C delta1
    55(a)3
    60.22(n)1
    57.47(a)1
      321911  NM_078616.31  NP_511171.31 
    worm
    (Caenorhabditis elegans)
    Secernentea tpa-11 , 3 protein kinase C3
    Protein TPA-11
    48(a)
    (best of 3)3
    55.19(n)1
    51.17(a)1
      IV(92052-110151)3
    1768251  NM_067459.21  NP_499860.11 


    ENSEMBL Gene Tree for PRKCD (if available)
    TreeFam Gene Tree for PRKCD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCD gene
    ENSG000002589892  PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  
    PRKCZ2  PKN32  PRKCG2  PKN22  
    15 SIMAP similar genes for PRKCD using alignment to 4 protein entries:     KPCD_HUMAN (see all proteins):
    PRKCQ    PKN2    AKT2    PRKCH    AKT3    PKN3
    PRKCE    PRKCI    AKT1    PKN1    PRKD1    PRKCZ
    PRKCA    PRKCG    PRKCB

    PRKCD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1266 SNPs in PRKCD are shown (see all 1266)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0061764
    ----see VAR_0061762 V M mis40--------
    VAR_0206104
    ----see VAR_0206102 M V mis40--------
    rs1898387511,2
    C--53195185(+) CGGGGC/TCGGCG 2 -- us2k10--------
    rs1822467851,2
    --53195611(+) CTGTCC/TGTCTG 2 -- int10--------
    rs1139945381,2
    F--53195648(+) CTGAGG/CTCCTT 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1451498211,2
    --53195764(+) TGTCGC/TCACCC 2 -- int10--------
    rs1145454421,2
    C,F--53195771(+) ACCCAC/TTCTGT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs799031211,2
    C,F--53196008(+) CCGCCC/TGCCGG 2 -- int11Minor allele frequency- T:0.50NA 2
    rs3777294241,2
    C--53196215(+) CCGATA/GGGTCT 2 -- int10--------
    rs93114891,2
    C,A--53196288(+) GGTCGC/GGGGGG 2 -- int1 trp33Minor allele frequency- G:0.29NA 124

    HapMap Linkage Disequilibrium report for PRKCD (53190025 - 53226733 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRKCD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv460554CNV Loss19166990
    nsv834699CNV Loss17160897
    nsv470583CNV Loss18288195
    nsv517233CNV Loss19592680
    nsv460553CNV Loss19166990


    Human Gene Mutation Database (HGMD): PRKCD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCD
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176977    OMIM disorders: --

    20/60 diseases for PRKCD (see all 60):    About MalaCards
    pneumonic plague    plague    brain ischemia    thymoma
    abdominal aortic aneurysm    aortic aneurysm    pituitary tumors    scleroderma
    ischemia    kaposi's sarcoma    colon cancer    diabetic retinopathy
    colon adenocarcinoma    parkinson's disease    fibrosarcoma    pheochromocytoma
    pertussis    adenocarcinoma    pulmonary fibrosis    sjogren's syndrome


    PRKCD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/20 Novoseek inferred disease relationships for PRKCD gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 27.2 6 19965895 (1), 8848016 (1), 15135084 (1), 19169273 (1) (see all 6)
    tumors 22.4 19 11470753 (2), 8999887 (1), 15386430 (1), 18653803 (1) (see all 16)
    colon cancer 15.4 3 15386430 (1), 15494216 (1), 18807195 (1)
    mammary tumor 6.55 1 10597283 (1)
    parkinson disease 4.59 3 15961393 (1), 18945348 (1), 19633700 (1)
    breast cancer 1.43 4 11595128 (1), 10221776 (1), 16617167 (1), 19903772 (1)
    adenocarcinoma lung 0.901 1 12525155 (1)
    gastric carcinoma 0.758 1 16598791 (1)
    carcinoma squamous cell 0 4 20093486 (2), 16158048 (1), 16424000 (1)
    ischemia 0 2 15167677 (1), 16111715 (1)

    Genetic Association Database (GAD): PRKCD
    Human Genome Epidemiology (HuGE) Navigator: PRKCD (6 documents)

    Export disorders for PRKCD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCD gene, integrated from 9 sources (see all 760):
    (articles sorted by number of sources associating them with PRKCD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. (PubMed id 8188219)1, 3, 9 Huppi K....Mischak H. (1994)
    2. Novel phosphorylation site markers of protein kinase C delta activation. (PubMed id 17603046)1, 2, 9 Durgan J....Parker P.J. (2007)
    3. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. (PubMed id 11877440)1, 2, 9 Ren J.... Kufe D. (2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Regulation of TNF-induced oxygen radical production i n human neutrophils: role of delta-PKC. (PubMed id 19801500)1, 2 Kilpatrick L.E....Korchak H.M. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    8. Identification of a Novel Antiapoptotic Human Protein Kinase C delta Isoform, PKCdeltaVIII in NT2 Cells. (PubMed id 18092819)1, 2 Jiang K.... Patel N.A. (2008)
    9. The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. (PubMed id 17579121)1, 2 Gomel R....Brodie C. (2007)
    10. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5580 HGNC: 9399 AceView: PRKCD Ensembl:ENSG00000163932 euGenes: HUgn5580
    ECgene: PRKCD Kegg: 5580 H-InvDB: PRKCD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKCD gene:
    Search GeneIP for patents involving PRKCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for PRKCD
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant PRKCD Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PRKCD (PKC delta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for PRKCD (PKC delta)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRKCD   OriGene RNAi products in human, mouse, rat for PRKCD  
     OriGene qPCR primer pairs and template standards for PRKCD   OriGene Protein Over-expression Lysate for PRKCD  
     OriGene MassSpec something-or-other for PRKCD   OriGene clones in human, mouse for PRKCD  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRKCD   OriGene Purified Protein for PRKCD  
     OriGene ORF clones in mouse, rat for PRKCD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKCD   OriGene Custom Protein Services for PRKCD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKCD
     QIAGEN SeqTarget long-range PCR primers for resequencing PRKCD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCD
     GenScript Custom Purified and Recombinant Proteins Services for PRKCD GenScript cDNA clones with any tag delivered in your preferred vector for PRKCD
     GenScript Custom Assay Services for PRKCD GenScript Superior Antibodies for PRKCD
     GenScript Custom overexpressing Cell Line Services for PRKCD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PRKCD  (PKCD)

     Regulatory tfbs in PRKCD promoter
     Search Chromatin IP Primers for PRKCD
     RT2 qPCR Primer Assay in human, mouse, rat PRKCD
     GNC Network for PRKCD
     SABiosciences PCR Arrays including human, mouse, rat PRKCD
     Tocris compounds for PRKCD
     Proteins and Antibodies for PRKCD
     Cell Lysates for PRKCD
     cDNA Clones for PRKCD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for PRKCD
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRKCD antibodies
     PRKCD proteins
     PRKCD lysates
     Antibodies for PRKCD
     See all of Abcam's Antibodies, Kits and Proteins for PRKCD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PRKCD




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PRKCD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD
     SwitchGear 3'UTR luciferase reporter plasmids for PRKCD
     SwitchGear Promoter luciferase reporter plasmids for PRKCD
     ThermoFisher Antibodies for PRKCD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKCD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKCD
    Customized:
     lentivirus for stable overexpression of PRKCD
     lentivirus expression plasmids for stable overexpression of PRKCD
     adenovirus for overexpression of PRKCD
     LSBio Antibodies in human, mouse, rat for PRKCD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRKCD gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4