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Aliases for PRKCD Gene

Aliases for PRKCD Gene

  • Protein Kinase C Delta 2 3 5
  • Tyrosine-Protein Kinase PRKCD 3 4
  • EC 2.7.11.13 4 58
  • NPKC-Delta 3 4
  • Protein Kinase C Delta VIII 3
  • Protein Kinase C Delta Type 3
  • Protein Kinase C, Delta 2
  • EC 2.7.10.2 4
  • EC 2.7.11 58
  • ALPS3 3
  • CVID9 3
  • MAY1 3
  • PKCD 3

External Ids for PRKCD Gene

Previous GeneCards Identifiers for PRKCD Gene

  • GC03P052287
  • GC03P052446
  • GC03P053050
  • GC03P053152
  • GC03P053170

Summaries for PRKCD Gene

Entrez Gene Summary for PRKCD Gene

  • The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

GeneCards Summary for PRKCD Gene

PRKCD (Protein Kinase C Delta) is a Protein Coding gene. Diseases associated with PRKCD include Autoimmune Lymphoproliferative Syndrome, Type Iii and Prkcd-Related Autoimmune Lymphoproliferative Syndrome. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AGE/RAGE pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot for PRKCD Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).

Tocris Summary for PRKCD Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCD Gene

Additional gene information for PRKCD Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCD Gene

Genomics for PRKCD Gene

Regulatory Elements for PRKCD Gene

Enhancers for PRKCD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H053233 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +83.4 83386 10 FOXA2 MLX ARID4B SIN3A GLI4 YY1 ZNF766 GLIS2 FOS REST PRKCD SNORD38C TKT DCP1A ITIH4 GNL3 TMEM110
GH03H053165 1.5 FANTOM5 ENCODE dbSUPER 21.1 +13.0 12953 7 HDGF PKNOX1 FOXA2 SIN3A ARID4B DMAP1 ZNF207 RUNX3 SP5 MIER2 PRKCD TMEM110 GLT8D1 TKT GNL3 DCP1A PBRM1
GH03H053195 1.5 Ensembl ENCODE dbSUPER 20.7 +40.6 40554 1 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZBTB7B BRCA1 GLIS2 ZNF143 RFT1 PRKCD PBRM1 SNORD38C TKT DCP1A ITIH4
GH03H053268 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +114.4 114368 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 FOS DEK PRKCD SNORD38C TKT SFMBT1 DCP1A GC03M053284 PIR47365
GH03H053140 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.5 -14.9 -14908 1 HDGF ZSCAN26 ZSCAN4 ZNF133 MAX EBF1 PAX8 SALL2 ZFHX2 FOXK2 GLT8D1 RFT1 NISCH PBRM1 PRKCD ACTR8 NEK4 TMEM110 ITIH4 DCP1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCD on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRKCD gene promoter:

Genomic Location for PRKCD Gene

Chromosome:
3
Start:
53,156,009 bp from pter
End:
53,192,717 bp from pter
Size:
36,709 bases
Orientation:
Plus strand

Genomic View for PRKCD Gene

Genes around PRKCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCD Gene

Proteins for PRKCD Gene

  • Protein details for PRKCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05655-KPCD_HUMAN
    Recommended name:
    Protein kinase C delta type
    Protein Accession:
    Q05655
    Secondary Accessions:
    • B0KZ81
    • B2R834
    • Q15144
    • Q86XJ6

    Protein attributes for PRKCD Gene

    Size:
    676 amino acids
    Molecular mass:
    77505 Da
    Quaternary structure:
    • Interacts with PDPK1 (via N-terminal region) (PubMed:11781095). Interacts with RAD9A (PubMed:12628935). Interacts with CDCP1 (PubMed:15851033). Interacts with MUC1 (PubMed:11877440). Interacts with VASP (PubMed:16940418). Interacts with CAVIN3 (By similarity). Interacts with PRKD2 (via N-terminus and zing-finger domain 1 and 2) in response to oxidative stress; the interaction is independent of PRKD2 tyrosine phosphorylation (PubMed:28428613).

    Three dimensional structures from OCA and Proteopedia for PRKCD Gene

    Alternative splice isoforms for PRKCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCD Gene

Selected DME Specific Peptides for PRKCD Gene

Q05655:
  • GIIYRDLK
  • KVANLCGINQKL
  • PPFRPKVKSP
  • VLGKGSFGKV
  • GKGSFGKV
  • GHIKIAD
  • DDDVECTMVEKRVL
  • WGLNKQGY
  • GVLLYEM
  • DFGMCKE
  • IDMPHRFK
  • LFFVMEFLNGGD
  • FAIKALKK
  • YRDLKLDN
  • TFCDHCGSLL
  • GTPDYIAPE
  • CNAAIHKKCIDK
  • TFCGTPDYIAPEI
  • QKKPTMYP
  • VDWWSFGVLLYEML
  • YIAPEIL
  • GQSPFHG
  • RDLKLDN
  • DRDGHIK

Post-translational modifications for PRKCD Gene

  • Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not a prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic reticulum and cleavage by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313 and Tyr-567 following thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2.
  • Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which results in kinase activation.
  • Ubiquitination at Lys184, Lys362, and isoforms=2613
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCD (PKCD)

Protein Products

Domains & Families for PRKCD Gene

Gene Families for PRKCD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05655

UniProtKB/Swiss-Prot:

KPCD_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
  • The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCD: view

Function for PRKCD Gene

Molecular function for PRKCD Gene

GENATLAS Biochemistry:
protein kinase C,delta polypeptide,involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-507 (activation loop of the kinase domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full activation. Activated by caspase-3 (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif in the regulatory subunit is released from the substrate recognition site of the catalytic subunit, which enables PRKCD to become constitutively activated. The catalytic subunit which displays properties of a sphingosine-dependent protein kinase is activated by D-erythro-sphingosine (Sph) or N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS), but not by ceramide or Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity).
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).

Enzyme Numbers (IUBMB) for PRKCD Gene

Phenotypes From GWAS Catalog for PRKCD Gene

Gene Ontology (GO) - Molecular Function for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 24008408
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity TAS --
GO:0004699 calcium-independent protein kinase C activity EXP,TAS 14583092
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with PRKCD: view
genes like me logo Genes that share phenotypes with PRKCD: view

Human Phenotype Ontology for PRKCD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKCD Gene

MGI Knock Outs for PRKCD:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRKCD

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCD
  • Applied Biological Materials Clones for PRKCD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for PRKCD Gene

Localization for PRKCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCD Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCD gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
lysosome 4
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 15632189
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15632189
GO:0005783 endoplasmic reticulum IDA 15774464
genes like me logo Genes that share ontologies with PRKCD: view

Pathways & Interactions for PRKCD Gene

genes like me logo Genes that share pathways with PRKCD: view

Pathways by source for PRKCD Gene

Gene Ontology (GO) - Biological Process for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IDA 10713049
GO:0006915 apoptotic process IDA 10770950
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with PRKCD: view

Drugs & Compounds for PRKCD Gene

(47) Drugs for PRKCD Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ingenol Mebutate Approved Pharma Target, ligand 0
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 399
Zoledronic acid Approved Pharma Inhibition, Inhibitor Potent nitrogen-containing bisphosphonates, Osteoclast function modifiers (important in bone metastasis) 297
nolvadex Approved October 1998 Pharma 0
Picato gel Approved January 2012 Pharma 0

(23) Additional Compounds for PRKCD Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCD Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8

(7) ApexBio Compounds for PRKCD Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Dequalinium Chloride 522-51-0
Go 6983 pan-PKC inhibitor 133053-19-7
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
Zoledronic Acid Potent nitrogen-containing bisphosphonates 118072-93-8
genes like me logo Genes that share compounds with PRKCD: view

Drug Products

Transcripts for PRKCD Gene

Unigene Clusters for PRKCD Gene

Protein kinase C, delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCD
  • Applied Biological Materials Clones for PRKCD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PRKCD Gene

GeneLoc Exon Structure for
PRKCD
ECgene alternative splicing isoforms for
PRKCD

Expression for PRKCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCD Gene

This gene is overexpressed in Whole Blood (x11.7).

Protein differential expression in normal tissues from HIPED for PRKCD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Heart (11.5), and Lymph node (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCD Gene



Protein tissue co-expression partners for PRKCD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCD Gene:

PRKCD

SOURCE GeneReport for Unigene cluster for PRKCD Gene:

Hs.155342

Evidence on tissue expression from TISSUES for PRKCD Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Liver(4.2)
  • Skin(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • hypothalamus
  • meninges
  • middle ear
  • mouth
  • neck
  • pituitary gland
  • sinus
  • skull
  • thyroid
Thorax:
  • bronchus
  • esophagus
  • heart
  • lung
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with PRKCD: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PRKCD Gene

Orthologs for PRKCD Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCD 34 33
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCD 34 33
  • 89.48 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCD 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcd 33
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia PRKCD 34 33
  • 87.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcd 16 34 33
  • 87.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCD 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCD 34 33
  • 76.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCD 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcd 33
  • 75.69 (n)
Str.11010 33
zebrafish
(Danio rerio)
Actinopterygii prkcdb 34
  • 76 (a)
OneToMany
prkcda 34 33
  • 71.47 (n)
OneToMany
wufb09d10 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000418 33
  • 60.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pkcdelta 33 34
  • 60.22 (n)
Pkcdgr 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea tpa-1 35 33 34
  • 55.4 (n)
R12G8.1 35
  • 42 (a)
F48G7.10 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToMany
Species where no ortholog for PRKCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCD Gene

ENSEMBL:
Gene Tree for PRKCD (if available)
TreeFam:
Gene Tree for PRKCD (if available)

Paralogs for PRKCD Gene

Paralogs for PRKCD Gene

(15) SIMAP similar genes for PRKCD Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKCD: view

Variants for PRKCD Gene

Sequence variations from dbSNP and Humsavar for PRKCD Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs398122958 Pathogenic 53,186,696(+) GCCAC(A/G)TACGT splice-donor-variant
rs606231296 Pathogenic 53,188,832(+) TCTGC(A/G)GCACC nc-transcript-variant, reference, missense
rs606231297 Pathogenic 53,189,969(+) AAAAG(C/T)GGAGG nc-transcript-variant, reference, missense
rs1057518393 Uncertain significance 53,187,347(+) TTTAT(A/G)CCGCT nc-transcript-variant, reference, missense
rs879255393 Uncertain significance 53,188,752(+) GGACC(A/G)GGATG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRKCD Gene

Variant ID Type Subtype PubMed ID
esv3325228 CNV duplication 20981092
esv3596168 CNV gain 21293372
nsv1144991 CNV deletion 24896259
nsv460553 CNV loss 19166990
nsv460554 CNV loss 19166990
nsv470583 CNV loss 18288195
nsv517233 CNV loss 19592680
nsv590357 CNV loss 21841781
nsv834699 CNV loss 17160897
nsv954863 CNV deletion 24416366

Variation tolerance for PRKCD Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCD Gene

Human Gene Mutation Database (HGMD)
PRKCD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCD Gene

Disorders for PRKCD Gene

MalaCards: The human disease database

(11) MalaCards diseases for PRKCD Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
autoimmune lymphoproliferative syndrome, type iii
  • autoimmune lymphoproliferative syndrome type 3
prkcd-related autoimmune lymphoproliferative syndrome
  • autoimmune lymphoproliferative syndrome, type iii
systemic lupus erythematosus 16
  • sleb16
autoimmune lymphoproliferative syndrome
  • autoimmune lymphoproliferative syndrome, type ib
common variable immunodeficiency
  • acquired agammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search PRKCD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KPCD_HUMAN
  • Autoimmune lymphoproliferative syndrome 3 (ALPS3) [MIM:615559]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. CVID9 patients have B-cell deficiency and severe autoimmunity. {ECO:0000269 PubMed:23319571}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PRKCD

Genetic Association Database (GAD)
PRKCD
Human Genome Epidemiology (HuGE) Navigator
PRKCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCD
genes like me logo Genes that share disorders with PRKCD: view

No data available for Genatlas for PRKCD Gene

Publications for PRKCD Gene

  1. Novel phosphorylation site markers of protein kinase C delta activation. (PMID: 17603046) Durgan J … Parker PJ (FEBS letters 2007) 3 4 22 60
  2. Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. (PMID: 17965192) Welman A … Dive C (Protein science : a publication of the Protein Society 2007) 3 4 22 60
  3. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. (PMID: 8188219) Huppi K … Mischak H (Genomics 1994) 2 3 22 60
  4. Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. (PMID: 28428613) Cobbaut M … Van Lint J (Scientific reports 2017) 3 4 60
  5. B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ. (PMID: 23319571) Salzer E … Boztug K (Blood 2013) 3 4 60

Products for PRKCD Gene

  • Addgene plasmids for PRKCD
  • antibodies-online