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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCD Gene

protein-coding   GIFtS: 71
GCID: GC03P053190

protein kinase C, delta
 Explore 65 diseases affiliated with
PRKCD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKCD    

Aliases
for PRKCD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase C, Delta1 2     PKCD2
Tyrosine-Protein Kinase PRKCD2 3     Protein Kinase C Delta Type2
NPKC-Delta1     Protein Kinase C Delta VIII2
EC 2.7.11.133 8     EC 2.7.10.23
MAY12     EC 2.7.118

External Ids:    HGNC: 93991   Entrez Gene: 55802   Ensembl: ENSG000001639327   OMIM: 1769775   UniProtKB: Q056553   

Export aliases for PRKCD gene to outside databases

Previous GC identifers: GC03P052287 GC03P052446 GC03P053050 GC03P053152 GC03P053170


Summaries
for PRKCD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKCD:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium
and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are
known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for
phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is
believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies
both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth,
apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same
protein have been observed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is
involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by
NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates
the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene
transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus,
causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex
with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger
apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis
protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation
treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial
cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX
activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates
phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the
CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can
phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from
the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of
AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against
chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival
pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation
with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox)
phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in
neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling
pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5,
leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and
actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1
in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates
14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)

summary for PRKCD:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCD


Genomic Views
for PRKCD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCD gene promoter:
         p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKCD promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

PRKCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053190:  view genomic region     (about GC identifiers)

Start:
 53,190,025 bp from pter      End:
 53,226,733 bp from pter
Size:
 36,709 bases      Orientation:
 plus strand

Proteins
for PRKCD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655 (See protein sequence)
Recommended Name: Protein kinase C delta type  
Size: 676 amino acids; 77505 Da
Subunit: Interacts with PDPK1 (via N-terminus region), RAD9A, CDCP1, MUC1 and VASP
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell
membrane; Peripheral membrane protein
2 PDB 3D structures from and Proteopedia for PRKCD:
1YRK (3D)        2YUU (3D)    
Secondary accessions: B0KZ81 B2R834 Q15144 Q86XJ6
Alternative splicing: 2 isoforms:  Q05655-1   Q05655-2   (Antiapoptotic isoform, resistant to caspase-3 cleavage)

Explore the universe of human proteins at neXtProt for PRKCD: NX_Q05655

Post-translational modifications:

  • Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not a
    • prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL treatment,
    phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic reticulum and cleavage
    by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313 and Tyr-567 following
    thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase PDPK1; phosphorylation is
    inhibited by the apoptotic C-terminus cleavage product of PKN21
  • Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which results
    • in kinase activation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05655

    • 4/24 DME Specific Peptides for PRKCD (Q05655) (see all 24)
     GVLLYEM  DFGMCKE  YIAPEIL  GQSPFHG 

    PRKCD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006245.2  NP_997704.1  

    ENSEMBL proteins: 
     ENSP00000419726   ENSP00000378217   ENSP00000331602   ENSP00000418106   ENSP00000419629  
    Reactome Protein details: Q05655
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PRKCD Protein
    R&D Systems Recombinant & Natural Proteins for PRKCD (PKC delta)
    Enzo Life Sciences proteins for PRKCD
    OriGene Purified Protein: PRKCD
    OriGene Protein Over-expression Lysate (see all 3): PRKCD
    OriGene Custom Protein Services for PRKCD 
    GenScript Custom Purified and Recombinant Proteins Services for PRKCD
    Novus Biologicals PRKCD Proteins
    Novus Biologicals PRKCD Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRKCD
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15774464
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--


    PRKCD for ontologies           About GeneDecksing



    PRKCD Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
    R&D Systems Antibodies for PRKCD (PKC delta)
    Cell Signaling Technology (CST) Antibodies for PRKCD  (PKCD)
    OriGene Antibodies (see all 4): PRKCD
    OriGene Custom Antibody Services for PRKCD 
    GenScript Superior Antibodies for PRKCD
    Novus Biologicals PRKCD Antibodies
    Abcam antibodies for PRKCD 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for PRKCD

    Assay Products for PRKCD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PRKCD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKCD for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR014376 Prot_kin_PKC_delta
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q05655

    ProtoNet protein and cluster: Q05655

    3 Blocks protein families:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
    Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor
    Domain: The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a
    sequence-specific manner
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Function
    for PRKCD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KPCD_HUMAN, Q05655
    Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
    plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA
    damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is
    involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by
    NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates
    the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene
    transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus,
    causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex
    with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger
    apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis
    protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation
    treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial
    cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX
    activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates
    phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the
    CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can
    phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from
    the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of
    AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against
    chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival
    pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation
    with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox)
    phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in
    neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling
    pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5,
    leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and
    actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and
    CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in
    PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1
    in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates
    14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol
    (DAG) and phosphatidylserine. Three specific sites; Thr-507 (activation loop of the kinase domain), Ser-645 (turn
    motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full activation. Activated by caspase-3
    (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif in the regulatory subunit is released
    from the substrate recognition site of the catalytic subunit, which enables PRKCD to become constitutively activated.
    The catalytic subunit which displays properties of a sphingosine-dependent protein kinase is activated by
    D-erythro-sphingosine (Sph) or N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS),
    but not by ceramide or Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity)

         Genatlas biochemistry entry for PRKCD:
    protein kinase C,delta polypeptide,involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding
    upon TPA stimulation

    Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112 EC 2.7.10.21

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): PRKCD
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCD
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: PRKCD 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCD (see all 7)
    OriGene shRNA RFP: PRKCD
    OriGene siRNA: PRKCD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCD

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKCD

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCD (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCD (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRKCD
    Search LifeMap BioReagents cell lines for PRKCD

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA10770950
    GO:0004697protein kinase C activity ISS--
    GO:0004699calcium-independent protein kinase C activity TAS14583092
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI12721299


    PRKCD for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for PRKCD:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased apoptosis 
     Increased cell death HMECs cel  Increased viability with TRAIL 

    Animal Models:
         Mouse knock-outs for PRKCD: Prkcdtm1Kin Prkcdtm1Msg
         13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Prkcd):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  renal/urinary system  skeleton 

    PRKCD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRKCD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/120 super-pathways (see all 120) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2ErbB4 Pathway
    8/11 pathways (see all 11)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		LPS Stimulated MAPK Signaling0.36
    		Prolactin Signaling0.54
    		VEGF Signaling Pathway0.35
    		ErbB2-ErbB3 Heterodimers0.47
    		Growth Hormone Signaling0.32
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4CCR3 Pathway in Eosinophils
    		CCR3 Pathway in Eosinophils1.00
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Alpha-Adrenergic Signaling0.31
    		fMLP Pathway0.43
    		Huntington's Disease Pathway0.18
    5Translation_Translation regulation by Alpha-1 adrenergic receptors
    		Translation_Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development_Activation of ERK by Alpha-1 adrenergic receptors0.64
    		Translation Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development Activation of ERK by Alpha-1 adrenergic receptors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/22 EMD Millipore Pathways for PRKCD (see all 22)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Development A1 receptor signaling

    2 R&D Systems Pathways for PRKCD
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling

    5/84 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCD (see all 84)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCD
        Ca, cAMP and Lipid Signaling

    2 Tocris Bioscience Pathways for PRKCD
        NF-kappaB Pathway
    VEGF Pathway

    5/22 GeneGo (Thomson Reuters) Pathways for PRKCD (see all 22)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development FGF-family signaling
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2

    5/37 BioSystems Pathways for PRKCD (see all 37) 
        Oncostatin M Signaling Pathway
    Myometrial Relaxation and Contraction Pathways
    Type II interferon signaling (IFNG)
    AGE/RAGE pathway
    G Protein Signaling Pathways

    5/48        Reactome Pathways for PRKCD (see all 48)
        Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Stabilization of mRNA by HuR
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for PRKCD
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/8         Kegg Pathways  (Kegg details for PRKCD) (see all 8):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    Tight junction
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis


    PRKCD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/248 Interacting proteins for PRKCD (Q056551, 2, 3 ENSP000003316024) via UniProtKB, MINT, STRING, and/or I2D (see all 248)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1Q9H5V82, 3, ENSP000002961294MINT-62341 MINT-62334 MINT-62336 MINT-62333 MINT-62332 MINT-62339 I2D: score=3 STRING: ENSP00000296129
    NCF1P145982, 3, ENSP000002894734MINT-3973536 I2D: score=2 STRING: ENSP00000289473
    PPM1AP358132, 3, ENSP000003272554MINT-8387176 I2D: score=2 STRING: ENSP00000327255
    ABL1P005192, 3, ENSP000003614234MINT-1955124 I2D: score=1 STRING: ENSP00000361423
    SRCP129312, 3, ENSP000003509414MINT-62340 MINT-62338 I2D: score=3 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006468protein phosphorylation IDA16611985
    GO:0006915apoptotic process TAS--
    GO:0006917induction of apoptosis IEA--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--


    PRKCD for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKCD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCD for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCD:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCD

    Compounds for PRKCD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Phorbol 12,13-dibutyrate Protein kinase C activator[37558-16-0]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    RottlerinReported PKCdelta inhibitor[82-08-6]
    PKC (19-36)Pseudosubstrate peptide; inhibitor of PKC[113731-96-7]

    10/846 HMDB Compounds for PRKCD (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    1 DrugBank Compound for PRKCD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    13-Acetylphorbol-- --target--10592235

    10/44 Novoseek chemical compound relationships for PRKCD gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rottlerin 96.1 34 17133362 (2), 17927688 (2), 10618482 (1), 16698440 (1) (see all 29)
    n-benzyladriamycin-14-valerate 82.7 1 11297449 (1)
    nsc-606985 82.6 2 19747914 (1), 19322780 (1)
    pkcs 82.5 2 20236250 (1), 16424000 (1)
    bryostatin 1 70.4 6 10194341 (2), 8077702 (1), 10626804 (1), 14725904 (1)
    phorbol 61.3 5 10713064 (1), 11595128 (1), 16183650 (1), 10818086 (1) (see all 5)
    tyrosine 60.6 36 7568083 (4), 10698304 (2), 15811957 (1), 11381116 (1) (see all 29)
    12-o-tetradecanoylphorbol 13-acetate 55.1 6 7830075 (2), 17964626 (1)
    phosphatidylinositol 48.6 5 11549843 (1), 8663229 (1), 11912175 (1), 19074768 (1) (see all 5)
    serine 48.5 4 11438522 (1), 9857052 (1), 9305920 (1), 16424000 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCD / KPCD 

    Transcripts
    for PRKCD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKCD gene (2 alternative transcripts): 
    NM_006254.3  NM_212539.1  

    Unigene Cluster for PRKCD:

    Protein kinase C, delta
    Hs.155342  [show with all ESTs]
    Unigene Representative Sequence: NM_006254
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478843 ENST00000394729(uc003dgl.3 uc003dgm.3) ENST00000330452(uc010hmt.1)
    ENST00000477794 ENST00000487897 ENST00000464818(uc003dgn.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): PRKCD
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCD
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCD (see all 25):
    hsa-miR-181c hsa-miR-3942-5p hsa-miR-513a-5p hsa-miR-15a hsa-miR-374a hsa-miR-606 hsa-miR-1297 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: PRKCD 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCD (see all 7)
    OriGene shRNA RFP: PRKCD
    OriGene siRNA: PRKCD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCD
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCD (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCD (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCD (NM_006254)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCD 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCD

    Additional cDNA sequence: 

    AK130150.1 AK294272.1 AK313216.1 BC043350.1 BC127261.1 D10495.1 DQ516383.1 L07860.1 
    L07861.1 Z22521.1 

    8 DOTS entries:

    DT.447562  DT.92327244  DT.100008116  DT.95092309  DT.100026851  DT.120850705  DT.91834194  DT.91713047 

    24/254 AceView cDNA sequences (see all 254):

    BE889730 BF446364 BQ086286 BM914479 BP336675 CK822956 BM967192 BM755813 
    CF141981 AI126073 BQ712651 NM_006254 BX378948 BM975717 CR596063 NM_212539 
    BF445845 BQ706214 CD518507 AI312882 BF939213 BF446886 AI127149 BI858343 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                    -                                   -                                                           -                                       
    SP2:              -     -                                   -                                                           -                                       
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for PRKCD

    Expression
    for PRKCD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGACTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKCD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCD

    SOURCE GeneReport for Unigene cluster: Hs.155342
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCD: 
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              Alzheimer's Disease in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCD
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCD

    Orthologs
    for PRKCD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PRKCD gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRKCD1 protein kinase C, delta 76.88(n)
    85.57(a)    		   415905  NM_001006133.1  NP_001006133.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PRKCD6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 2(155711992-155751256)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB109739.12   -- 79.63(n)    AB109739.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb09d102 Danio rerio mRNA similar to protein kinase C, delta more 75.7(n)    BC049327.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pkc&dgr;3
    Pkcdelta1    		 protein amino acid phosphorylation protein
    serine/threonine more3
    Protein kinase C delta1    		 55(a)3
    60.22(n)1
    57.47(a)1    		   321911  NM_078616.31  NP_511171.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea tpa-11 , 3 protein kinase C3
    Protein TPA-11    		 48(a)
    (best of 3)3
    55.19(n)1
    51.17(a)1    		   IV(92052-110151)3
    1768251  NM_067459.21  NP_499860.11 


    ENSEMBL Gene Tree for PRKCD (if available)
    TreeFam Gene Tree for PRKCD (if available) 

    Paralogs
    for PRKCD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCD gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  
    PKN32  PRKCG2  PKN22  
    15 SIMAP similar genes for PRKCD using alignment to 4 protein entries:     KPCD_HUMAN (see all proteins):
    PRKCQ    PKN2    PRKCH    AKT2    AKT3    PKN3
    PRKCE    PRKCI    AKT1    PKN1    PRKD1    PRKCZ
    PRKCA    PRKCG    PRKCB

    PRKCD for paralogs           About GeneDecksing



    Genomic Variants
    for PRKCD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 NCBI SNPs in PRKCD are shown (see all 647)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1898387511,2
    		C,--53195185(+) CGGGGC/TCGGCG 2 -- us2k10--------
    rs1822467851,2
    		--53195611(+) CTGTCC/TGTCTG 2 -- int10--------
    rs1139945381,2
    		F,--53195648(+) CTGAGG/CTCCTT 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1451498211,2
    		--53195764(+) TGTCGC/TCACCC 2 -- int10--------
    rs1145454421,2
    		F,--53195771(+) ACCCAC/TTCTGT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs799031211,2
    		--53196008(+) CCGCCC/TGCCGG 2 -- int11Minor allele frequency- T:0.50NA 2
    rs93114891,2
    		C,A,--53196288(+) GGTCGC/GGGGGG 2 -- int1 trp33Minor allele frequency- G:0.29NA 124
    rs93114901,2
    		C,--53196361(+) CCCCAA/GTTCCC 2 -- int113Minor allele frequency- G:0.02NA WA CSA EA 375
    rs1868453961,2
    		--53196400(+) CGAGCC/TCCGCC 2 -- int10--------
    rs1404984601,2
    		--53196411(+) TTAAAC/TCTGGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRKCD (53190025 - 53226733 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PRKCD
         1 CNV: 51119

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKCD
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCD

    Disorders / Diseases
    for PRKCD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKCD for disorders           About GeneDecksing

    OMIM gene information: 176977    OMIM disorders: --

    20/65 diseases for PRKCD (see all 65):    About MalaCards
    pneumonic plague    abdominal aortic aneurysm    aortic aneurysm    myeloid leukemia
    acute myeloid leukemia    plague    kaposi's sarcoma    diabetic retinopathy
    brain ischemia    parkinson's disease    renal cell carcinoma    squamous cell carcinoma
    pituitary tumor    pulmonary fibrosis    ischemia    colon cancer
    hepatitis c    adenocarcinoma    carcinoma    thymoma

    10/20 Novoseek disease relationships for PRKCD gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 27.2 6 19965895 (1), 8848016 (1), 15135084 (1), 19169273 (1) (see all 6)
    tumors 22.4 19 11470753 (2), 8999887 (1), 15386430 (1), 18653803 (1) (see all 16)
    colon cancer 15.4 3 15386430 (1), 15494216 (1), 18807195 (1)
    mammary tumor 6.55 1 10597283 (1)
    parkinson disease 4.59 3 15961393 (1), 18945348 (1), 19633700 (1)
    breast cancer 1.43 4 11595128 (1), 10221776 (1), 16617167 (1), 19903772 (1)
    adenocarcinoma lung 0.901 1 12525155 (1)
    gastric carcinoma 0.758 1 16598791 (1)
    carcinoma squamous cell 0 4 20093486 (2), 16158048 (1), 16424000 (1)
    ischemia 0 2 15167677 (1), 16111715 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRKCD (6 documents)

    Export disorders for PRKCD gene to outside databases

    Publications
    for PRKCD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCD gene, integrated from 9 sources (see all 731):
    (articles sorted by number of sources associating them with PRKCD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. (PubMed id 8188219)1, 3, 9 Huppi K....Mischak H. (1994)
    2. Novel phosphorylation site markers of protein kinase C delta activation. (PubMed id 17603046)1, 2, 9 Durgan J....Parker P.J. (2007)
    3. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. (PubMed id 11877440)1, 2, 9 Ren J.... Kufe D. (2002)
    4. Regulation of TNF-induced oxygen radical production i n human neutrophils: role of delta-PKC. (PubMed id 19801500)1, 2 Kilpatrick L.E....Korchak H.M. (2010)
    5. Identification of a Novel Antiapoptotic Human Protein Kinase C delta Isoform, PKCdeltaVIII in NT2 Cells. (PubMed id 18092819)1, 2 Jiang K.... Patel N.A. (2008)
    6. The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. (PubMed id 17579121)1, 2 Gomel R....Brodie C. (2007)
    7. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (2005)
    8. Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. (PubMed id 15774464)1, 2 Okhrimenko H....Brodie C. (2005)
    9. Protein kinase Cdelta is responsible for constitutive and DNA damage- induced phosphorylation of Rad9. (PubMed id 12628935)1, 2 Yoshida K.... Kufe D. (2003)
    10. Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. (PubMed id 11781095)1, 2 Hodgkinson C.P. and Sale G.J. (2002)

    External Searches for PRKCD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKCD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5580 HGNC: 9399 AceView: PRKCD Ensembl:ENSG00000163932 euGenes: HUgn5580
    ECgene: PRKCD Kegg: 5580 H-InvDB: PRKCD

    Other Databases showing PRKCD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKCD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCD Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PRKCD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKCD gene:
    Search GeneIP for patents involving PRKCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRKCD gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCD
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     Antibodies & Assays for PRKCD  (PKCD)

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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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