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Aliases for PRKCB Gene

Aliases for PRKCB Gene

  • Protein Kinase C Beta 2 3 5
  • EC 2.7.11.13 4 58
  • PKC-Beta 3 4
  • PRKCB1 3 4
  • PKC-B 3 4
  • PKCB 3 4
  • Protein Kinase C, Beta 1 Polypeptide 3
  • Protein Kinase C Beta Type 3
  • Protein Kinase C, Beta 1 2
  • Protein Kinase C, Beta 2
  • EC 2.7.11 58
  • PRKCB2 3

External Ids for PRKCB Gene

Previous HGNC Symbols for PRKCB Gene

  • PRKCB2
  • PKCB
  • PRKCB1

Previous GeneCards Identifiers for PRKCB Gene

  • GC16P023755
  • GC16P021938

Summaries for PRKCB Gene

Entrez Gene Summary for PRKCB Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCB Gene

PRKCB (Protein Kinase C Beta) is a Protein Coding gene. Diseases associated with PRKCB include Glioblastoma and Hyperglycemia. Among its related pathways are GABAergic synapse and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot for PRKCB Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Gene Wiki entry for PRKCB Gene

Additional gene information for PRKCB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCB Gene

Genomics for PRKCB Gene

Regulatory Elements for PRKCB Gene

Enhancers for PRKCB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H023898 1.5 Ensembl ENCODE dbSUPER 45.4 +66.1 66086 7 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 RUNX3 NCOA1 PRKCB RBBP6 PALB2 ENSG00000260751 ENSG00000261669 GC16P023879 GC16M023957
GH16H023855 1.9 FANTOM5 Ensembl ENCODE dbSUPER 35.7 +24.5 24538 9 PKNOX1 ATF1 ZNF766 ELK1 ZNF143 ZNF207 ATF7 RUNX3 CAVIN1 JUNB PRKCB RBBP6 PALB2 ENSG00000260751 ENSG00000260482 ENSG00000261669 GGA2 GC16M023859
GH16H023946 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.8 +113.9 113850 7 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 RUNX3 CAVIN1 PRKCB RBBP6 PALB2 ENSG00000260751 ENSG00000261669 GGA2 GC16M023957 GC16P023879
GH16H023880 1.3 Ensembl ENCODE dbSUPER 25.6 +45.5 45472 2 EBF1 CEBPG BATF RELA EED SCRT2 ADNP ATF7 PRDM10 ETV6 PRKCB GC16P023879 GC16M023957
GH16H023906 1.2 ENCODE dbSUPER 26.7 +71.7 71667 1 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ZNF592 SMARCA4 ZNF184 PRKCB GC16P023879 GC16M023957
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCB on UCSC Golden Path with GeneCards custom track

Promoters for PRKCB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084588 521 1801 PKNOX1 SIN3A ZNF2 YY1 GLIS2 ELK1 ZNF143 RUNX3 SP3 REST

Transcription factor binding sites by QIAGEN in the PRKCB gene promoter:

Genomic Location for PRKCB Gene

Chromosome:
16
Start:
23,835,979 bp from pter
End:
24,220,611 bp from pter
Size:
384,633 bases
Orientation:
Plus strand

Genomic View for PRKCB Gene

Genes around PRKCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCB Gene

Proteins for PRKCB Gene

  • Protein details for PRKCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05771-KPCB_HUMAN
    Recommended name:
    Protein kinase C beta type
    Protein Accession:
    P05771
    Secondary Accessions:
    • C5IFJ8
    • D3DWF5
    • O43744
    • P05127
    • Q15138
    • Q93060
    • Q9UE49
    • Q9UE50
    • Q9UEH8
    • Q9UJ30
    • Q9UJ33

    Protein attributes for PRKCB Gene

    Size:
    671 amino acids
    Molecular mass:
    76869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR.

    Three dimensional structures from OCA and Proteopedia for PRKCB Gene

    Alternative splice isoforms for PRKCB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCB Gene

Selected DME Specific Peptides for PRKCB Gene

P05771:
  • VNGGDLM
  • FYAAEIAIGLF
  • GIIYRDLK
  • VRDAKNL
  • VLGKGSFGKV
  • DDPRSKHKFKIHTY
  • NEELRQKFERAKI
  • GKGSFGKV
  • EAVAICKG
  • GHIKIAD
  • GVLLYEMLAGQ
  • RNDFMGSLSFG
  • DDDVECTMVEKRVL
  • ESKQKTKTI
  • EKRVLAL
  • GEDEDELFQSIMEH
  • RFFKQPTFCSHC
  • MNVHKRC
  • GVLLYEM
  • DFGMCKE
  • AGQAPFEG
  • VKLKLIPD
  • VDWWAFGVL
  • RCHEFVTF
  • QDDDVECTM
  • TPTDKLFIMNLDQ
  • GALRQKNVHE
  • RKGALRQK
  • ICKGLMTKHP
  • FYAAEIA
  • TSRNDFMG
  • VDGWFKLLSQEEGEYFNVPVPPEGSE
  • WGFGKQG
  • YRDLKLDN
  • TFCDHCGSLL
  • DRLYFVME
  • DHTERRGR
  • PMDPNGL
  • LHSCFQT
  • GTPDYIAPE
  • TFCGTPDYIAPEI
  • CPGADKG
  • KRLGCGP
  • GTDELYAVK
  • FVMEYVNGG
  • PYGKSVD
  • LSFGISE
  • VVHKRCH
  • KRLGCGPEGERD
  • RDLKLDN

Post-translational modifications for PRKCB Gene

  • Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).
  • Ubiquitination at Lys141 and Lys489
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCB (PKCB iso2)
  • Cell Signaling Technology (CST) Antibodies for PRKCB (PKCB)

Domains & Families for PRKCB Gene

Gene Families for PRKCB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05771

UniProtKB/Swiss-Prot:

KPCB_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCB: view

Function for PRKCB Gene

Molecular function for PRKCB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCB Gene

Phenotypes From GWAS Catalog for PRKCB Gene

Gene Ontology (GO) - Molecular Function for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20228790
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity TAS --
GO:0004698 calcium-dependent protein kinase C activity TAS --
genes like me logo Genes that share ontologies with PRKCB: view
genes like me logo Genes that share phenotypes with PRKCB: view

Animal Models for PRKCB Gene

MGI Knock Outs for PRKCB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCB
  • Applied Biological Materials Clones for PRKCB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCB Gene

Localization for PRKCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCB Gene

Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCB gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 20228790
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 15632189
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKCB: view

Pathways & Interactions for PRKCB Gene

genes like me logo Genes that share pathways with PRKCB: view

Pathways by source for PRKCB Gene

SIGNOR curated interactions for PRKCB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRKCB: view

Drugs & Compounds for PRKCB Gene

(67) Drugs for PRKCB Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 428,431
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 399
Atenolol Approved Pharma Antagonist 107
Dexmedetomidine Approved, Vet_approved Pharma Partial agonist, Agonist 631
Ingenol Mebutate Approved Pharma 0

(34) Additional Compounds for PRKCB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCB Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8

(17) ApexBio Compounds for PRKCB Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine PKC inhibitor 34316-15-9
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Midostaurin (PKC412) PKC inhibitor 120685-11-2
PKC β pseudosubstrate 172308-76-8
Ro 31-8220 pan-PKC inhibitor 125314-64-9
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Verbascoside PKC/NF-κB inhibitor 61276-17-3
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCB: view

Drug Products

Transcripts for PRKCB Gene

Unigene Clusters for PRKCB Gene

Protein kinase C, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCB
  • Applied Biological Materials Clones for PRKCB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCB Gene

No ASD Table

Relevant External Links for PRKCB Gene

GeneLoc Exon Structure for
PRKCB
ECgene alternative splicing isoforms for
PRKCB

Expression for PRKCB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCB Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.4), Brain - Caudate (basal ganglia) (x5.3), Brain - Putamen (basal ganglia) (x5.2), Brain - Cortex (x5.0), Whole Blood (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for PRKCB Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (12.9), and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKCB Gene



Protein tissue co-expression partners for PRKCB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKCB Gene:

PRKCB

SOURCE GeneReport for Unigene cluster for PRKCB Gene:

Hs.460355

Evidence on tissue expression from TISSUES for PRKCB Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PRKCB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKCB Gene

Orthologs for PRKCB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCB Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia PRKCB 34
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCB 33 34
  • 96.09 (n)
cow
(Bos Taurus)
Mammalia PRKCB 34 33
  • 93.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCB 33 34
  • 92.93 (n)
mouse
(Mus musculus)
Mammalia Prkcb 33 16 34
  • 91.48 (n)
rat
(Rattus norvegicus)
Mammalia Prkcb 33
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCB 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCB 33 34
  • 81.88 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcb 33
  • 80.27 (n)
Str.18182 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34027 33
zebrafish
(Danio rerio)
Actinopterygii prkcba 34
  • 79 (a)
OneToMany
prkcbb 33 34
  • 78.26 (n)
zgc63591 33
fruit fly
(Drosophila melanogaster)
Insecta Pkc53E 34
  • 64 (a)
ManyToMany
inaC 34
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pkc-2 34
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck1 33
  • 51.01 (n)
Species where no ortholog for PRKCB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCB Gene

ENSEMBL:
Gene Tree for PRKCB (if available)
TreeFam:
Gene Tree for PRKCB (if available)

Paralogs for PRKCB Gene

Variants for PRKCB Gene

Sequence variations from dbSNP and Humsavar for PRKCB Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs764534677 A colorectal adenocarcinoma sample 24,035,448(+) GCTGC(A/G)TGATG reference, missense
VAR_042305 A glioblastoma multiforme sample
rs1000003251 -- 23,876,894(+) CATAT(C/T)CTTTG intron-variant
rs1000004113 -- 23,897,374(+) TTTTG(A/G)ATATA intron-variant
rs1000007541 -- 24,171,785(+) CTGGA(G/T)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCB Gene

Variant ID Type Subtype PubMed ID
dgv1324n106 CNV tandem duplication 24896259
dgv1325n106 CNV deletion 24896259
dgv1326n106 CNV deletion 24896259
dgv487e199 CNV deletion 23128226
dgv4958n54 CNV loss 21841781
dgv4959n54 CNV loss 21841781
dgv808e212 CNV loss 25503493
esv1064145 CNV deletion 17803354
esv1347038 CNV insertion 17803354
esv1982695 CNV deletion 18987734
esv2108885 CNV deletion 18987734
esv2251377 CNV deletion 18987734
esv2282551 CNV deletion 18987734
esv23662 CNV loss 19812545
esv2452495 CNV deletion 19546169
esv2654032 CNV deletion 19546169
esv2662823 CNV deletion 23128226
esv2714097 CNV deletion 23290073
esv2714098 CNV deletion 23290073
esv2714099 CNV deletion 23290073
esv2714100 CNV deletion 23290073
esv2714101 CNV deletion 23290073
esv2714102 CNV deletion 23290073
esv2714103 CNV deletion 23290073
esv2714104 CNV deletion 23290073
esv2714105 CNV deletion 23290073
esv2714106 CNV deletion 23290073
esv2714108 CNV deletion 23290073
esv2714109 CNV deletion 23290073
esv27468 CNV loss 19812545
esv3199346 CNV deletion 24192839
esv3388855 CNV insertion 20981092
esv34056 CNV loss 18971310
esv3553247 CNV deletion 23714750
esv3553249 CNV deletion 23714750
esv3553251 CNV deletion 23714750
esv3638240 CNV loss 21293372
esv3638241 CNV loss 21293372
esv3638242 CNV loss 21293372
esv3638243 CNV loss 21293372
esv3638244 CNV gain 21293372
esv5194 CNV loss 18987735
esv7420 CNV loss 19470904
esv997589 CNV deletion 20482838
nsv103651 CNV deletion 16902084
nsv103660 CNV deletion 16902084
nsv1070759 CNV deletion 25765185
nsv1070760 CNV deletion 25765185
nsv1070761 CNV deletion 25765185
nsv1108995 CNV deletion 24896259
nsv1115917 CNV deletion 24896259
nsv1119449 CNV insertion 24896259
nsv1146896 CNV insertion 26484159
nsv1150639 CNV deletion 26484159
nsv472091 CNV novel sequence insertion 20440878
nsv472712 CNV novel sequence insertion 20440878
nsv473852 CNV novel sequence insertion 20440878
nsv527537 CNV loss 19592680
nsv571696 CNV loss 21841781
nsv833174 CNV gain 17160897
nsv952955 CNV deletion 24416366
nsv952956 CNV deletion 24416366
nsv958200 CNV deletion 24416366

Variation tolerance for PRKCB Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCB Gene

Disorders for PRKCB Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRKCB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
hyperglycemia
microvascular complications of diabetes 5
  • diabetic nephropathy
autistic disorder
  • autism
amphetamine abuse
- elite association - COSMIC cancer census association via MalaCards
Search PRKCB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCB

Genetic Association Database (GAD)
PRKCB
Human Genome Epidemiology (HuGE) Navigator
PRKCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCB
genes like me logo Genes that share disorders with PRKCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCB Gene

Publications for PRKCB Gene

  1. Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells. (PMID: 7880442) Mahajna J … Haley J (DNA and cell biology 1995) 3 4 22 60
  2. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. (PMID: 1400396) Obeid LM … Hannun YA (The Journal of biological chemistry 1992) 3 4 22 60
  3. Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II. (PMID: 3658678) Kubo K … Suzuki K (Nucleic acids research 1987) 2 3 4 60
  4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 45 60
  5. Functional alterations in protein kinase C beta II expression in melanoma. (PMID: 20015121) Voris JP … Denning MF (Pigment cell & melanoma research 2010) 3 22 60

Products for PRKCB Gene

  • Addgene plasmids for PRKCB