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Aliases for PRKCB Gene

Aliases for PRKCB Gene

  • Protein Kinase C Beta 2 3
  • Protein Kinase C, Beta 2 5
  • EC 2.7.11.13 4 63
  • PKC-Beta 3 4
  • PRKCB1 3 4
  • PKC-B 3 4
  • PKCB 3 4
  • Protein Kinase C, Beta 1 Polypeptide 3
  • Protein Kinase C, Beta 1 2
  • EC 2.7.11 63
  • PRKCB2 3

External Ids for PRKCB Gene

Previous HGNC Symbols for PRKCB Gene

  • PRKCB2
  • PKCB
  • PRKCB1

Previous GeneCards Identifiers for PRKCB Gene

  • GC16P023755
  • GC16P021938

Summaries for PRKCB Gene

Entrez Gene Summary for PRKCB Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCB Gene

PRKCB (Protein Kinase C Beta) is a Protein Coding gene. Diseases associated with PRKCB include diabetic macular edema and microvascular complications of diabetes 5. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot for PRKCB Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Gene Wiki entry for PRKCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCB Gene

Genomics for PRKCB Gene

Regulatory Elements for PRKCB Gene

Promoters for PRKCB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRKCB gene promoter:

Genomic Location for PRKCB Gene

Chromosome:
16
Start:
23,835,979 bp from pter
End:
24,220,611 bp from pter
Size:
384,633 bases
Orientation:
Plus strand

Genomic View for PRKCB Gene

Genes around PRKCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCB Gene

Proteins for PRKCB Gene

  • Protein details for PRKCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05771-KPCB_HUMAN
    Recommended name:
    Protein kinase C beta type
    Protein Accession:
    P05771
    Secondary Accessions:
    • C5IFJ8
    • D3DWF5
    • O43744
    • P05127
    • Q15138
    • Q93060
    • Q9UE49
    • Q9UE50
    • Q9UEH8
    • Q9UJ30
    • Q9UJ33

    Protein attributes for PRKCB Gene

    Size:
    671 amino acids
    Molecular mass:
    76869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR.

    Three dimensional structures from OCA and Proteopedia for PRKCB Gene

    Alternative splice isoforms for PRKCB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCB Gene

Proteomics data for PRKCB Gene at MOPED

Post-translational modifications for PRKCB Gene

  • Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).
  • Ubiquitination at Lys 141 and Lys 489
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCB (PKCB)
  • Cell Signaling Technology (CST) Antibodies for PRKCB (PKCB)

Domains & Families for PRKCB Gene

Suggested Antigen Peptide Sequences for PRKCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05771

UniProtKB/Swiss-Prot:

KPCB_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCB: view

Function for PRKCB Gene

Molecular function for PRKCB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCB Gene

Gene Ontology (GO) - Molecular Function for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20228790
GO:0035403 histone kinase activity (H3-T6 specific) IDA 20228790
GO:0042393 histone binding IDA 20228790
GO:0050681 androgen receptor binding IDA 20228790
genes like me logo Genes that share ontologies with PRKCB: view
genes like me logo Genes that share phenotypes with PRKCB: view

Animal Models for PRKCB Gene

MGI Knock Outs for PRKCB:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCB Gene

Localization for PRKCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCB Gene

Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCB Gene COMPARTMENTS Subcellular localization image for PRKCB gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PRKCB: view

Pathways & Interactions for PRKCB Gene

genes like me logo Genes that share pathways with PRKCB: view

Pathways by source for PRKCB Gene

SIGNOR curated interactions for PRKCB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006468 protein phosphorylation IEA,TAS 3755548
GO:0006816 calcium ion transport IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction NAS 3755548
genes like me logo Genes that share ontologies with PRKCB: view

Drugs & Compounds for PRKCB Gene

(55) Drugs for PRKCB Gene - From: Novoseek, ApexBio, HMDB, DGIdb, IUPHAR, Tocris, DrugBank, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved Nutra Target 371,376
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 350
Dexmedetomidine Approved Pharma Partial agonist, Agonist 470
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0

(43) Additional Compounds for PRKCB Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCB Gene

Compound Action Cas Number
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
PKC fragment (530-558) Potent activator of protein kinase C 122613-29-0
Pseudo RACK1 Protein kinase C activator peptide (attached to cell permeable vector)
SC-10 Protein kinase C activator 102649-79-6
SC-9 Protein kinase C activator 102649-78-5

(10) ApexBio Compounds for PRKCB Gene

Compound Action Cas Number
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCB: view

Drug Products

Transcripts for PRKCB Gene

Unigene Clusters for PRKCB Gene

Protein kinase C, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCB Gene

No ASD Table

Relevant External Links for PRKCB Gene

GeneLoc Exon Structure for
PRKCB
ECgene alternative splicing isoforms for
PRKCB

Expression for PRKCB Gene

mRNA expression in normal human tissues for PRKCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCB Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.4), Brain - Caudate (basal ganglia) (x5.3), Brain - Putamen (basal ganglia) (x5.2), Brain - Cortex (x5.0), Whole Blood (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for PRKCB Gene

This gene is overexpressed in Lymph node (19.0), Peripheral blood mononuclear cells (12.9), and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCB Gene



SOURCE GeneReport for Unigene cluster for PRKCB Gene Hs.460355

genes like me logo Genes that share expression patterns with PRKCB: view

Protein tissue co-expression partners for PRKCB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRKCB Gene

Orthologs for PRKCB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRKCB 35
  • 92.93 (n)
  • 98.66 (a)
PRKCB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcb 35
  • 91.23 (n)
  • 98.37 (a)
mouse
(Mus musculus)
Mammalia Prkcb 16
Prkcb 36
  • 99 (a)
OneToOne
Prkcb 35
  • 91.48 (n)
  • 98.81 (a)
cow
(Bos Taurus)
Mammalia PRKCB 36
  • 99 (a)
OneToOne
PRKCB 35
  • 93.26 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCB 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCB 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCB 36
  • 99 (a)
OneToOne
PRKCB 35
  • 96.09 (n)
  • 95.78 (a)
chicken
(Gallus gallus)
Aves PRKCB 35
  • 81.88 (n)
  • 91.79 (a)
PRKCB 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcb 35
  • 80.27 (n)
  • 91.18 (a)
Str.18182 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34027 35
zebrafish
(Danio rerio)
Actinopterygii zgc63591 35
prkcba 36
  • 79 (a)
OneToMany
prkcbb 36
  • 87 (a)
OneToMany
prkcbb 35
  • 78.26 (n)
  • 88.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pkc53E 36
  • 64 (a)
ManyToMany
inaC 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pkc-2 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck1 35
  • 51.01 (n)
  • 44.18 (a)
Species with no ortholog for PRKCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCB Gene

ENSEMBL:
Gene Tree for PRKCB (if available)
TreeFam:
Gene Tree for PRKCB (if available)

Paralogs for PRKCB Gene

Paralogs for PRKCB Gene

genes like me logo Genes that share paralogs with PRKCB: view

Variants for PRKCB Gene

Sequence variations from dbSNP and Humsavar for PRKCB Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_042304 A colorectal adenocarcinoma sample
VAR_042305 A glioblastoma multiforme sample
rs35631544 - 24,191,130(+) TGGAC(A/C/G)TGAAG reference, missense
rs3380 -- 24,214,944(+) GACAG(A/T)GTTTC intron-variant, utr-variant-3-prime
rs23555 -- 24,142,593(+) ctaga(A/C/G)tgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCB Gene

Variant ID Type Subtype PubMed ID
esv271312 CNV Insertion 20981092
esv272650 CNV Insertion 20981092
esv1347038 CNV Insertion 17803354
nsv103660 CNV Loss 16902084
esv2282551 CNV Deletion 18987734
nsv103651 CNV Loss 16902084
esv2654032 CNV Deletion 19546169
esv2714097 CNV Deletion 23290073
esv1982695 CNV Deletion 18987734
esv2714098 CNV Deletion 23290073
esv997589 CNV Deletion 20482838
esv2452495 CNV Deletion 19546169
esv1064145 CNV Deletion 17803354
esv7420 CNV Loss 19470904
esv23662 CNV Loss 19812545
esv2662823 CNV Deletion 23128226
esv2714099 CNV Deletion 23290073
esv2714100 CNV Deletion 23290073
esv2714101 CNV Deletion 23290073
esv2714102 CNV Deletion 23290073
esv5194 CNV Deletion 18987735
esv2714103 CNV Deletion 23290073
esv2714104 CNV Deletion 23290073
nsv527537 CNV Loss 19592680
esv2251377 CNV Deletion 18987734
esv2714105 CNV Deletion 23290073
nsv833174 CNV Gain 17160897
esv2714106 CNV Deletion 23290073
dgv487e199 CNV Deletion 23128226
esv34056 CNV Loss 18971310
esv2714108 CNV Deletion 23290073
esv2108885 CNV Deletion 18987734
esv2714109 CNV Deletion 23290073
esv27468 CNV Loss 19812545

Variation tolerance for PRKCB Gene

Residual Variation Intolerance Score: 7.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCB Gene

HapMap Linkage Disequilibrium report
PRKCB
Human Gene Mutation Database (HGMD)
PRKCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCB Gene

Disorders for PRKCB Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRKCB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetic macular edema
microvascular complications of diabetes 5
  • diabetic nephropathy
myotonic dystrophy 1
  • major affective disorder 1
macular retinal edema
  • macular edema
hyperglycemia
- elite association - COSMIC cancer census association via MalaCards
Search PRKCB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRKCB

Genetic Association Database (GAD)
PRKCB
Human Genome Epidemiology (HuGE) Navigator
PRKCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCB
genes like me logo Genes that share disorders with PRKCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKCB Gene

Publications for PRKCB Gene

  1. Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II. (PMID: 3658678) Kubo K. … Suzuki K. (Nucleic Acids Res. 1987) 2 3 4 67
  2. Vascular endothelial growth factor stimulates protein kinase CbetaII expression in chronic lymphocytic leukemia cells. (PMID: 20164467) Abrams S.T. … Slupsky J.R. (Blood 2010) 3 23
  3. Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells. (PMID: 20179100) Numaga T. … Mori Y. (J. Cell. Sci. 2010) 3 23
  4. Protein kinase C-beta gene variants, pathway activation, and enzastaurin activity in lung cancer. (PMID: 20439192) Lee S.H. … Bepler G. (Clin Lung Cancer 2010) 3 23
  5. Functional alterations in protein kinase C beta II expression in melanoma. (PMID: 20015121) Voris J.P. … Denning M.F. (Pigment Cell Melanoma Res 2010) 3 23

Products for PRKCB Gene

  • Cloud-Clone Corp. Antibodies for PRKCB