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PRKCB Gene

protein-coding   GIFtS: 71
GCID: GC16P023847

Protein Kinase C, Beta

(Previous names: protein kinase C, beta 1)
(Previous symbols: PRKCB2, PKCB, PRKCB1)
  See PRKCB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Beta1 2     EC 2.7.11.133 8
PKCB1 2 3 5     Protein Kinase C, Beta 11
PRKCB11 2 3 5     Protein Kinase C Beta Type2
PRKCB21 2     Protein Kinase C, Beta 1 Polypeptide2
PKC-B2 3     EC 2.7.118
PKC-beta2 3     

External Ids:    HGNC: 93951   Entrez Gene: 55792   Ensembl: ENSG000001665017   OMIM: 1769705   UniProtKB: P057713   

Export aliases for PRKCB gene to outside databases

Previous GC identifers: GC16P023755 GC16P021938


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCB Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets
and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major
receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression
profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC
family members. This protein kinase has been reported to be involved in many different cellular functions, such
as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.
Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced
conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCB Gene:
PRKCB (protein kinase C, beta) is a protein-coding gene. Diseases associated with PRKCB include diabetic macular edema. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCB_HUMAN, P05771
Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative
stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial
cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation.
Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at
'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and
recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in
nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR
signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the
alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis
following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform
p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species
producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR
target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for
epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A.
In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis
through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes
by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high
glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via
regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1,
increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS)
regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By
similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription

Gene Wiki entry for PRKCB (PRKCB1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCB gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKCB promoter sequence
   Search Chromatin IP Primers for PRKCB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

PRKCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCB gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P023847:  view genomic region     (about GC identifiers)

Start:
23,847,300 bp from pter      End:
24,231,932 bp from pter
Size:
384,633 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KPCB_HUMAN, P05771 (See protein sequence)
Recommended Name: Protein kinase C beta type  
Size: 671 amino acids; 76869 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity)
Subunit: Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2;
both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR
1 PDB 3D structure from and Proteopedia for PRKCB:
2I0E (3D)    
Secondary accessions: C5IFJ8 D3DWF5 O43744 P05127 Q15138 Q93060 Q9UE49 Q9UE50 Q9UEH8 Q9UJ30
Q9UJ33
Alternative splicing: 2 isoforms:  P05771-1   P05771-2   (Contains a phosphoserine at position 660. Contains a phosphothreonine at position 641)

Explore the universe of human proteins at neXtProt for PRKCB: NX_P05771

Explore proteomics data for PRKCB at MOPED

Post-translational modifications: 

  • Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent
    autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to
    release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions
    have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to
    the activation of MAPK/ERK signaling cascade (By similarity)1
  • Ubiquitination2 at Lys45, Lys76, Lys141, Lys391, Lys489
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCB (P05771) (see all 50)
     VNGGDLM  VRDAKNL  FYAAEIA  WGFGKQG 


    See PRKCB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002729.2  NP_997700.1  

    ENSEMBL proteins: 
     ENSP00000318315   ENSP00000305355   ENSP00000454428   ENSP00000459227   ENSP00000457980  
     ENSP00000458564  
    Reactome Protein details: P05771

    PRKCB Human Recombinant Protein Products:

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    Novus Biologicals PRKCB Proteins
    Novus Biologicals PRKCB Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRKCB
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCB 

    PRKCB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCB
    R&D Systems Antibodies for PRKCB (PKC beta 2, PKC beta 1)
    Cell Signaling Technology (CST) Antibodies for PRKCB (PKCB iso2, PKCB)
    OriGene Antibodies for PRKCB
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    Novus Biologicals PRKCB Antibodies
    Abcam antibodies for PRKCB
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    ThermoFisher Antibody for PRKCB
    LSBio Antibodies in human, mouse, rat for PRKCB

    PRKCB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for PRKCB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, beta
    Protein kinase C
    Alpha subfamily

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P05771

    ProtoNet protein and cluster: P05771

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCB_HUMAN, P05771
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCB_HUMAN, P05771
    Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase
    involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative
    stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial
    cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation.
    Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at
    'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and
    recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in
    nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR
    signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the
    alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis
    following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform
    p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species
    producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR
    target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for
    epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A.
    In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis
    through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes
    by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high
    glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via
    regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1,
    increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS)
    regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By
    similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and
    diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the
    kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full
    activation. Specifically inhibited by enzastaurin (LY317615)

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with PRKCB           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRKCB:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Increased cell number in G2M,  

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkcb):
     behavior/neurological  cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system 

    Find genes that share phenotypes with PRKCB           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKCB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKCB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKCB:
    hsa-mir-124-3p (MIRT022275)

    Block miRNA regulation of human, mouse, rat PRKCB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCB (see all 9):
    hsa-miR-203 hsa-miR-3607-3p hsa-miR-548am hsa-miR-27a hsa-miR-1179 hsa-miR-7 hsa-miR-550b hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidPRKCB 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRKCB (NM_002738)
    Sino Biological Human cDNA Clone for PRKCB
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    Addgene plasmids for PRKCB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCB_HUMAN, P05771: Cytoplasm (By similarity). Nucleus. Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA15632189
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with PRKCB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCB About   (see all 93)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF signaling pathway0.39
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    3ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    Development Angiotensin signaling via beta Arrestin0.39
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50


    Find genes that share SuperPaths with PRKCB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PRKCB
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCB (see all 80)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods

    1 Cell Signaling Technology (CST) Pathway for PRKCB
        Ca, cAMP and Lipid Signaling

    3 Tocris Bioscience Pathways for PRKCB
        Insulin Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCB (see all 15)
        Development VEGF signaling via VEGFR2 - generic cascades
    Development FGF-family signaling
    Signal transduction cAMP signaling
    Development EGFR signaling pathway
    Development Angiotensin signaling via beta-Arrestin

    Selected BioSystems Pathways for PRKCB (see all 27)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway

    5 Sino Biological Pathways for PRKCB
        EGFR Signaling Pathway
    Notch Signaling Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway
    NF-kB (NFkB) Pathway

    Selected Reactome Pathways for PRKCB (see all 7)
        Disinhibition of SNARE formation
    Depolymerisation of the Nuclear Lamina
    WNT5A-dependent internalization of FZD4
    Response to elevated platelet cytosolic Ca2+
    Activation of NF-kappaB in B cells

    4 PharmGKB Pathways for PRKCB
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCB) (see all 56):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCB (see all 12): 
              mTOR Signaling in human mouse rat
              Leukemia in human mouse rat
              Alzheimer's Disease in human mouse rat
              VEGF Signaling in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCB (P057711, 2, 3 ENSP000003053554) via UniProtKB, MINT, STRING, and/or I2D (see all 297)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006468protein phosphorylation TAS3755548
    GO:0006816calcium ion transport IEA--
    GO:0006874cellular calcium ion homeostasis IEA--

    Find genes that share ontologies with PRKCB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKCB
    10 ApexBio Compounds for PRKCB     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Browse Tocris compounds for PRKCB (KPCB)

    Selected HMDB Compounds for PRKCB (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    3 DrugBank Compounds for PRKCB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 17016423 15184978 11850093 10644549
    O-PhosphoethanolamineColamine phosphoric acid (see all 2)1071-23-4target--17139284 17016423 10592235
    Ellagic Acid-- 476-66-4targetinhibitor, competitive9581512

    2 IUPHAR Ligands for PRKCB (protein kinase C, beta)    About this table
    LigandTypeActionAffinityPubmed IDs
    ruboxistaurin
    InhibitorInhibition8.38709095
    CGP53353
    InhibitorInhibition6.49121494

    Selected Novoseek inferred chemical compound relationships for PRKCB gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ruboxistaurin 95.7 34 16384948 (3), 16307493 (2), 19825373 (2), 16249561 (1) (see all 23)
    ly333531 94.2 23 12540629 (2), 15067074 (1), 10452527 (1), 11356718 (1) (see all 16)
    ly317615 91.8 10 19112601 (1), 18462865 (1), 14593497 (1), 17766700 (1) (see all 6)
    hispidin 81.8 4 16374459 (1), 16936115 (1), 16441551 (1), 12566375 (1)
    pkcs 79.1 7 19112601 (1), 9117107 (1), 18783200 (1), 15591124 (1) (see all 6)
    go 6976 77.6 3 15591124 (1), 16441551 (1), 9497487 (1)
    12-deoxyphorbol-13-phenylacetate-20-acetate 69.3 1 8308000 (1)
    bisindolylmaleimide 68.6 4 10618482 (1), 14962104 (1)
    gf 109203x 67.6 8 14578299 (1), 19077250 (1), 16285992 (1), 17901075 (1) (see all 5)
    phorbol 66.2 10 8308000 (2), 11707282 (1), 8694856 (1), 9413940 (1) (see all 9)

    1 PharmGKB related drug/compound annotation for PRKCB gene    About this table
    Drug/compound PharmGKB Annotation
    dexmedetomidineCA  



    Find genes that share compounds with PRKCB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKCB gene (2 alternative transcripts): 
    NM_002738.6  NM_212535.2  

    Unigene Cluster for PRKCB:

    Protein kinase C, beta
    Hs.460355  [show with all ESTs]
    Unigene Representative Sequence: NM_002738
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321728(uc002dmd.3) ENST00000303531(uc002dme.3) ENST00000498058
    ENST00000498739 ENST00000486868 ENST00000482000 ENST00000472066 ENST00000463752
    ENST00000487674 ENST00000466124
    miRNA
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    hsa-miR-203 hsa-miR-3607-3p hsa-miR-548am hsa-miR-27a hsa-miR-1179 hsa-miR-7 hsa-miR-550b hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidPRKCB 3' UTR sequence
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    Addgene plasmids for PRKCB 
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      QuantiFast Probe-based Assays in human, mouse, rat PRKCB

    Additional mRNA sequence: 

    AJ002788.1 AK057555.1 AK123381.1 AL833252.1 BC036472.1 BC045175.2 M13975.1 X06318.1 
    X07109.1 

    13 DOTS entries:

    DT.215913  DT.215912  DT.102834600  DT.120707986  DT.75186984  DT.120707950  DT.120707913  DT.95289505 
    DT.86846418  DT.92325932  DT.97801822  DT.120708022  DT.95314865 

    Selected AceView cDNA sequences (see all 313):

    BC036472 AI436426 AW590569 AI381600 AW968002 AV728862 BE676169 AA810597 
    AW608634 BM722940 AW575552 AW002912 AA262174 NM_212535 Z42558 AW373276 
    BU733787 F02882 Z45874 F06702 AI538427 BP367288 BU730067 AA989561 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRKCB Expression
    About this image


    PRKCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    PRKCB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460355
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCB (see all 12): 
              mTOR Signaling in human mouse rat
              Leukemia in human mouse rat
              Alzheimer's Disease in human mouse rat
              VEGF Signaling in human mouse rat
              Diabetes in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkcb1 , 5 protein kinase C, beta1, 5 91.48(n)1
    98.81(a)1
      7 (65.75 cM)5
    187511  NM_008855.21  NP_032881.11 
     1222887515 
    chicken
    (Gallus gallus)
    Aves PRKCB1 protein kinase C, beta 81.88(n)
    91.79(a)
      416567  XM_414868.4  XP_414868.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.340272 Xenopus laevis transcribed sequence with moderate similarity more 82.25(n)    BJ069178.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635912 similar to protein kinase C, beta 80.58(n)   393953  BC055154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc53E6
    inaC6
    inactivation no afterpotential C
    64(a)
    49(a)
    many ↔ many
    many ↔ many
    2R(12812160-12832631)
    2R(12786088-12789083)
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-26
    Protein PKC-2, isoform c (pkc-2) mRNA, complete cd...
    48(a)
    1 → many
    X(9364818-9386035) WBGene00004033


    ENSEMBL Gene Tree for PRKCB (if available)
    TreeFam Gene Tree for PRKCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCB gene
    PRKCQ2  PRKCH2  PRKCI2  PRKCE2  PKN12  PRKCA2  PRKCZ2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCB using alignment to 4 protein entries:     KPCB_HUMAN (see all proteins) (see all similar genes):
    PRKCA    PRKCG    PRKD1    PRKCZ    KIN27    PRKCI
    PRKACB    PRKACA    AKT3    PRKCE    RASA4    AKT1
    SGK2    RPS6KA3    RPS6KA5    RPS6KB1    CHR11SYT    PKN1

    Find genes that share paralogs with PRKCB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCB (see all 8690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423044
    A colorectal adenocarcinoma sample4--see VAR_0423042 V M mis40--------
    VAR_0423054
    A glioblastoma multiforme sample4--see VAR_0423052 V M mis40--------
    rs1883421681,2
    C--21938453(+) CCTCTC/TGGGCT 2 -- ut510--------
    rs1137098281,2
    C--21943391(+) CTCCAC/TCTCCT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs284747091,2
    C--21949563(+) ATCCAC/TCCATC 2 -- int14Minor allele frequency- T:0.00WA CSA 6
    rs3750742281,2
    C--21967893(+) CCGGC-/ATATATATATAT
    ATATATATATATAT
    ATATA
    2 -- int10--------
    rs1860762541,2
    --21967921(+) TATATA/GTATAT 2 -- int10--------
    rs1907931611,2
    --21967923(+) TATATA/GTATAT 2 -- int10--------
    rs105833061,2
    C--21968431(+) TAAGT-/GAAA  
            
    GAAAG
    2 -- int11Minor allele frequency- GAAA:0.00CSA 2
    rs37853991,2
    C,H--21975528(-) TGTGTG/TTTTAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRKCB (23847300 - 24097300 bp, first 250kb of PRKCB)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKCB (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2108885CNV Deletion18987734
    dgv487e199CNV Deletion23128226
    esv2714103CNV Deletion23290073
    esv2251377CNV Deletion18987734
    esv2714100CNV Deletion23290073
    esv1064145CNV Deletion17803354
    esv997589CNV Deletion20482838
    esv2714097CNV Deletion23290073
    esv2714102CNV Deletion23290073
    esv2282551CNV Deletion18987734

    Human Gene Mutation Database (HGMD): PRKCB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCB
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176970    OMIM disorders: --

    1 disease for PRKCB:    
    About MalaCards
    diabetic macular edema


    Find genes that share disorders with PRKCB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKCB gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic retinopathy 63.3 13 14737743 (1), 17472415 (1), 15209756 (1), 16200860 (1) (see all 12)
    diabetic macular edema 60.5 2 16186374 (1), 19951615 (1)
    hyperglycemia 56.2 10 12540629 (2), 20184965 (1), 14986905 (1), 17494892 (1) (see all 8)
    diabetic nephropathies 52.2 12 12874455 (4), 12540629 (2), 17693752 (1), 18485142 (1) (see all 7)
    myeloid leukemia 46.2 3 9858570 (1), 10438532 (1), 11746831 (1)
    retinopathy 41.5 4 20431074 (1), 20141354 (1), 12507628 (1)
    promyelocytic leukemia 40.9 1 1445803 (1)
    macular edema 40.3 1 12507628 (1)
    microangiopathy diabetic 39.6 4 14757134 (2), 17160912 (1), 11304414 (1)
    blindness 34.7 1 16989901 (1)

    Genetic Association Database (GAD): PRKCB
    Human Genome Epidemiology (HuGE) Navigator: PRKCB (16 documents)

    Export disorders for PRKCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCB gene, integrated from 10 sources (see all 639):
    (articles sorted by number of sources associating them with PRKCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II. (PubMed id 3658678)1, 2, 3 Kubo K.... Suzuki K. (Nucleic Acids Res. 1987)
    2. Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells. (PubMed id 7880442)1, 2, 9 Mahajna J.... Haley J. (DNA Cell Biol. 1995)
    3. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. (PubMed id 1400396)1, 2, 9 Obeid L.M.... Hannun Y.A. (J. Biol. Chem. 1992)
    4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    5. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. (PubMed id 20228790)1, 2 Metzger E.... Schule R. (Nature 2010)
    6. The phosphatase PHLPP controls the cellular levels of protein kinase C. (PubMed id 18162466)1, 2 Gao T.... Newton A.C. (J. Biol. Chem. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. (PubMed id 11598012)1, 2 Kang S.W....Rawlings D.J. (EMBO J. 2001)
    10. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5579 HGNC: 9395 AceView: PRKCB1 Ensembl:ENSG00000166501 euGenes: HUgn5579
    ECgene: PRKCB Kegg: 5579 H-InvDB: PRKCB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKCB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prkcb1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKCB gene:
    Search GeneIP for patents involving PRKCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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