Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRKCB Gene

Aliases for PRKCB Gene

  • Protein Kinase C, Beta 2 3
  • PRKCB1 3 4 6
  • PKCB 3 4 6
  • EC 2.7.11.13 4 64
  • PKC-Beta 3 4
  • PKC-B 3 4
  • Protein Kinase C, Beta 1 Polypeptide 3
  • Protein Kinase C Beta Type 3
  • Protein Kinase C, Beta 1 2
  • EC 2.7.11 64
  • PRKCB2 3

External Ids for PRKCB Gene

Previous Symbols for PRKCB Gene

  • PRKCB2
  • PKCB
  • PRKCB1

Summaries for PRKCB Gene

Entrez Gene Summary for PRKCB Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCB Gene

PRKCB (Protein Kinase C, Beta) is a Protein Coding gene. Diseases associated with PRKCB include diabetic macular edema and myotonic dystrophy 1. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot for PRKCB Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Gene Wiki entry for PRKCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCB Gene

Genomics for PRKCB Gene

Genomic Location for PRKCB Gene

Start:
23,835,979 bp from pter
End:
24,220,611 bp from pter
Size:
384,633 bases
Orientation:
Plus strand

Genomic View for PRKCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCB Gene

Regulatory Elements for PRKCB Gene

Transcription factor binding sites by QIAGEN in the PRKCB gene promoter:

Proteins for PRKCB Gene

  • Protein details for PRKCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05771-KPCB_HUMAN
    Recommended name:
    Protein kinase C beta type
    Protein Accession:
    P05771
    Secondary Accessions:
    • C5IFJ8
    • D3DWF5
    • O43744
    • P05127
    • Q15138
    • Q93060
    • Q9UE49
    • Q9UE50
    • Q9UEH8
    • Q9UJ30
    • Q9UJ33

    Protein attributes for PRKCB Gene

    Size:
    671 amino acids
    Molecular mass:
    76869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.;
    Quaternary structure:
    • Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1. Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation. Interacts with KDM1A/LSD1, PKN1 and ANDR.

    Three dimensional structures from OCA and Proteopedia for PRKCB Gene

    Alternative splice isoforms for PRKCB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCB Gene

Proteomics data for PRKCB Gene at MOPED

Post-translational modifications for PRKCB Gene

  • Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. in the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys45, Lys76, Lys141, Lys391, and Lys489

Other Protein References for PRKCB Gene

Domains for PRKCB Gene

UniProtKB/Swiss-Prot:

KPCB_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P05771
  • Contains 1 C2 domain.:
    • P05771
  • Contains 1 protein kinase domain.:
    • P05771
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.:
    • P05771
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.:
    • P05771
genes like me logo Genes that share domains with PRKCB: view

Function for PRKCB Gene

Molecular function for PRKCB Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).
UniProtKB/Swiss-Prot Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates Ser-36 of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCB Gene

Gene Ontology (GO) - Molecular Function for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20228790
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with PRKCB: view
genes like me logo Genes that share phenotypes with PRKCB: view

miRNA for PRKCB Gene

miRTarBase miRNAs that target PRKCB

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKCB Gene

Localization for PRKCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCB Gene

Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCB Gene COMPARTMENTS Subcellular localization image for PRKCB gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20228790
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15632189
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PRKCB: view

Pathways for PRKCB Gene

genes like me logo Genes that share pathways with PRKCB: view

Pathways by source for PRKCB Gene

Gene Ontology (GO) - Biological Process for PRKCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001666 NOT response to hypoxia IDA 18323529
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IMP 20228790
GO:0006468 protein phosphorylation TAS 3755548
genes like me logo Genes that share ontologies with PRKCB: view

Compounds for PRKCB Gene

(10) ApexBio Compounds for PRKCB Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(846) HMDB Compounds for PRKCB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(3) Drugbank Compounds for PRKCB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ellagic Acid
476-66-4 target inhibitor, competitive
O-Phosphoethanolamine
  • Colamine phosphoric acid
1071-23-4 target
Vitamin E
  • alpha-Tocopherol
59-02-9 target

(2) IUPHAR Ligand for PRKCB Gene

Ligand Type Action Affinity Pubmed IDs
ruboxistaurin Inhibitor Inhibition 8.3
CGP53353 Inhibitor Inhibition 6.4

(65) Novoseek inferred chemical compound relationships for PRKCB Gene

Compound -log(P) Hits PubMed IDs
ruboxistaurin 95.7 27
ly333531 94.2 17
ly317615 91.8 6
hispidin 81.8 4
pkcs 79.1 6

(1) PharmGKB related drug/compound annotations for PRKCB Gene

Drug/compound Annotation
dexmedetomidine CA
genes like me logo Genes that share compounds with PRKCB: view

Transcripts for PRKCB Gene

Unigene Clusters for PRKCB Gene

Protein kinase C, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCB Gene

No ASD Table

Relevant External Links for PRKCB Gene

GeneLoc Exon Structure for
PRKCB
ECgene alternative splicing isoforms for
PRKCB

Expression for PRKCB Gene

mRNA expression in normal human tissues for PRKCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCB Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Frontal Cortex (BA9) (5.4), Brain - Caudate (basal ganglia) (5.3), Brain - Putamen (basal ganglia) (5.2), Brain - Cortex (5.0), Whole Blood (4.9), and Brain - Nucleus accumbens (basal ganglia) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCB Gene

SOURCE GeneReport for Unigene cluster for PRKCB Gene Hs.460355

genes like me logo Genes that share expressions with PRKCB: view

Orthologs for PRKCB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCB 36
  • 96.09 (n)
  • 95.78 (a)
PRKCB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCB 36
  • 93.26 (n)
  • 98.37 (a)
PRKCB 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCB 36
  • 92.93 (n)
  • 98.66 (a)
PRKCB 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcb 36
  • 91.48 (n)
  • 98.81 (a)
Prkcb 16
Prkcb 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCB 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCB 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcb 36
  • 91.23 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves PRKCB 36
  • 81.88 (n)
  • 91.79 (a)
PRKCB 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34027 36
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcb 36
  • 80.27 (n)
  • 91.18 (a)
Str.18182 36
zebrafish
(Danio rerio)
Actinopterygii prkcba 37
  • 79 (a)
OneToMany
prkcbb 36
  • 78.26 (n)
  • 88.01 (a)
prkcbb 37
  • 87 (a)
OneToMany
zgc63591 36
fruit fly
(Drosophila melanogaster)
Insecta inaC 37
  • 49 (a)
ManyToMany
Pkc53E 37
  • 64 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pkc-2 37
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 39
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck1 36
  • 51.01 (n)
  • 44.18 (a)
Species with no ortholog for PRKCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCB Gene

ENSEMBL:
Gene Tree for PRKCB (if available)
TreeFam:
Gene Tree for PRKCB (if available)

Paralogs for PRKCB Gene

Paralogs for PRKCB Gene

genes like me logo Genes that share paralogs with PRKCB: view

Variants for PRKCB Gene

Sequence variations from dbSNP and Humsavar for PRKCB Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3380 -- 24,214,944(+) GACAG(A/T)GTTTC utr-variant-3-prime, intron-variant
rs23555 -- 24,142,593(+) ctaga(A/C/G)tgtgg intron-variant
rs120908 -- 23,952,771(+) GTGAA(A/C)AAATA intron-variant
rs120909 -- 23,979,585(+) ATATG(A/G)CATAA intron-variant
rs169029 -- 23,951,030(+) CCCAG(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCB Gene

Variant ID Type Subtype PubMed ID
esv271312 CNV Insertion 20981092
esv272650 CNV Insertion 20981092
esv1347038 CNV Insertion 17803354
nsv103660 CNV Loss 16902084
esv2282551 CNV Deletion 18987734
nsv103651 CNV Loss 16902084
esv2654032 CNV Deletion 19546169
esv2714097 CNV Deletion 23290073
esv1982695 CNV Deletion 18987734
esv2714098 CNV Deletion 23290073
esv997589 CNV Deletion 20482838
esv2452495 CNV Deletion 19546169
esv1064145 CNV Deletion 17803354
esv7420 CNV Loss 19470904
esv23662 CNV Loss 19812545
esv2662823 CNV Deletion 23128226
esv2714099 CNV Deletion 23290073
esv2714100 CNV Deletion 23290073
esv2714101 CNV Deletion 23290073
esv2714102 CNV Deletion 23290073
esv5194 CNV Deletion 18987735
esv2714103 CNV Deletion 23290073
esv2714104 CNV Deletion 23290073
nsv527537 CNV Loss 19592680
esv2251377 CNV Deletion 18987734
esv2714105 CNV Deletion 23290073
nsv833174 CNV Gain 17160897
esv2714106 CNV Deletion 23290073
dgv487e199 CNV Deletion 23128226
esv34056 CNV Loss 18971310
esv2714108 CNV Deletion 23290073
esv2108885 CNV Deletion 18987734
esv2714109 CNV Deletion 23290073
esv27468 CNV Loss 19812545

Relevant External Links for PRKCB Gene

HapMap Linkage Disequilibrium report
PRKCB
Human Gene Mutation Database (HGMD)
PRKCB

Disorders for PRKCB Gene

(47) Novoseek inferred disease relationships for PRKCB Gene

Disease -log(P) Hits PubMed IDs
diabetic retinopathy 63.3 12
diabetic macular edema 60.5 2
hyperglycemia 56.2 9
diabetic nephropathies 52.2 11
myeloid leukemia 46.2 3

Relevant External Links for PRKCB

Genetic Association Database (GAD)
PRKCB
Human Genome Epidemiology (HuGE) Navigator
PRKCB
genes like me logo Genes that share disorders with PRKCB: view

No data available for UniProtKB/Swiss-Prot for PRKCB Gene

Publications for PRKCB Gene

  1. Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells. (PMID: 7880442) Mahajna J. … Haley J. (DNA Cell Biol. 1995) 3 4 23
  2. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. (PMID: 1400396) Obeid L.M. … Hannun Y.A. (J. Biol. Chem. 1992) 3 4 23
  3. Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II. (PMID: 3658678) Kubo K. … Suzuki K. (Nucleic Acids Res. 1987) 2 3 4
  4. Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences. (PMID: 3666134) Kubo K. … Suzuki K. (FEBS Lett. 1987) 3 4
  5. Alternative splicing increases the diversity of the human protein kinase C family. (PMID: 3677994) Coussens L. … Ullrich A. (DNA 1987) 3 4

Products for PRKCB Gene

  • Addgene plasmids for PRKCB

Sources for PRKCB Gene

Back to Top

Content