Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCA Gene

protein-coding   GIFtS: 75
GCID: GC17P064298

Protein Kinase C, Alpha


(Previous symbol: PKCA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase C, Alpha1 2     EC 2.7.11.133 8
PKCA1 2 3 5     AAG62
PKC-A2 3     Aging-Associated Gene 62
PKC-alpha2 3     Protein Kinase C Alpha Type2
PRKACA2 3     EC 2.7.118

External Ids:    HGNC: 93931   Entrez Gene: 55782   Ensembl: ENSG000001542297   OMIM: 1769605   UniProtKB: P172523   

Export aliases for PRKCA gene to outside databases

Previous GC identifers: GC17M063614 GC17M066678 GC17P064716 GC17P064849 GC17P061729 GC17P059689


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKCA Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of
the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as
cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice
suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCA Gene: 
PRKCA (protein kinase C, alpha) is a protein-coding gene. Diseases associated with PRKCA include pituitary tumors, and myofibrillar myopathy, and among its related super-pathways are ErbB signaling pathway and Wnt signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is ENSG00000258989.

UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
(ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation
of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation
of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent
kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can
trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated
growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic
function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of
IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage
differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is
associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and
participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4,
which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell
accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a
tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers.
Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and
thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a
MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte
hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface
area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial
contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN),
and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube
formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced
cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4
receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for
adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions
involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate
NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon
stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1
binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to
inhibition of KIT activity

summary for PRKCA Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCA (PKC alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCA gene promoter:
         GR   STAT1   AP-1   GR-beta   IRF-1   CREB   IRF-2   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCA promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q22-q24

PRKCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P064298:  view genomic region     (about GC identifiers)

Start:
64,298,754 bp from pter      End:
64,806,862 bp from pter
Size:
508,109 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252 (See protein sequence)
Recommended Name: Protein kinase C alpha type  
Size: 672 amino acids; 76750 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity)
Subunit: Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1 (By
similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Interacts with PICK1 (via PDZ domain). Interacts with TRIM41
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral
membrane protein (Probable). Nucleus
3 PDB 3D structures from and Proteopedia for PRKCA:
2ELI (3D)        3IW4 (3D)        4DNL (3D)    
Secondary accessions: B5BU22 Q15137 Q32M72 Q96RE4

Explore the universe of human proteins at neXtProt for PRKCA: NX_P17252

Explore proteomics data for PRKCA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17252

  • 4/50 DME Specific Peptides for PRKCA (P17252) (see all 50)
     VNGGDLM  GTEELYA  VRDAKNL  FFRRIDW 

    PRKCA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKCA Protein Expression
    REFSEQ proteins: NP_002728.1  
    ENSEMBL proteins: 
     ENSP00000462087   ENSP00000408695   ENSP00000284384  
    Reactome Protein details: P17252
    Human Recombinant Protein Products for PRKCA: 
    EMD Millipore Purified and/or Recombinant PRKCA Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCA
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRKCA
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PRKCA
    GenScript Custom Purified and Recombinant Proteins Services for PRKCA
    Novus Biologicals PRKCA Proteins
    Novus Biologicals PRKCA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PRKCA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ----

    PRKCA for ontologies           About GeneDecksing



    PRKCA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCA
    R&D Systems Antibodies for PRKCA (PKC alpha)
    Cell Signaling Technology (CST) Antibodies for PRKCA  (PKCA)
    OriGene Antibodies for PRKCA
    OriGene Custom Antibody Services for PRKCA
    GenScript Superior Antibodies for PRKCA
    Novus Biologicals PRKCA Antibodies
    Abcam antibodies for PRKCA
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PRKCA
    LSBio Antibodies in human, mouse, rat for PRKCA 

    Assay Products for PRKCA: 
    EMD Millipore Kits and Assays for the Analysis of PRKCA
    OriGene Custom Assay Services for PRKCA
    Browse R&D Systems for biochemical assays
    GenScript PRKCA-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, alpha 
    Delta subfamily
    Protein kinase C

    5/14 InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P17252

    ProtoNet protein and cluster: P17252

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    PRKCA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCA_HUMAN, P17252
    Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
    is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
    adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
    phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
    (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation
    of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation
    of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent
    kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can
    trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated
    growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic
    function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of
    IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage
    differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is
    associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and
    participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4,
    which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell
    accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a
    tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers.
    Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and
    thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a
    MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte
    hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface
    area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
    significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial
    contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN),
    and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube
    formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced
    cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4
    receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for
    adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions
    involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate
    NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon
    stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1
    binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to
    inhibition of KIT activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and
    diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the
    kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full
    activation

         Genatlas biochemistry entry for PRKCA:
    protein kinase C,alpha polypeptide

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004697protein kinase C activity ISS--
    GO:0004698calcium-dependent protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    PRKCA for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PRKCA:
     Decreased focal adhesion (FA)   Gemcitabine induced cell-death  Increased cell death HMECs cel  Increased colony dispersion (i 
     Increases Tamoxifen sensitivit 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkca):
     adipose tissue  cardiovascular system  homeostasis/metabolism  integument  muscle 
     nervous system  tumorigenesis 

    PRKCA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKCA: Prkcatm1Cda Prkcatm1Far Prkcatm1Jmk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKCA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKCA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCA
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRKCA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCA
    Sirion Biotech Validated adenovirus to knockdown PRKCA (PKC-alpha) in human, mouse 
                         Customized adenovirus for overexpression of PRKCA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRKCA (see all 5)
    OriGene ORF clones in mouse, rat for PRKCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
    Sino Biological Human cDNA Clone for PRKCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA
    Sirion Biotech Customized lentivirus for stable overexpression of PRKCA 
                         Customized lentivirus expression plasmids for stable overexpression of PRKCA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCA
    Search LifeMap BioReagents cell lines for PRKCA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKCA About   (see all 156)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    3Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    5VEGF Family Ligands and Receptor Interactions
    VEGF Family Ligands and Receptor Interactions0.66
    CCKBR-Gastrin Stimulated Signaling0.36
    VEGF Pathway0.66
    Development VEGF-family signaling0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/23 EMD Millipore Pathways for PRKCA (see all 23)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for PRKCA
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    5/83 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCA (see all 83)
        Fc-GammaR Pathway
    Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCA
        Ca, cAMP and Lipid Signaling

    5 Tocris Bioscience Pathways for PRKCA
        Insulin Pathway
    NF-kappaB Pathway
    VEGF Pathway
    MAPK Pathway
    mTOR Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for PRKCA (see all 24)
        Development FGF-family signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development VEGF-family signaling

    5/41 BioSystems Pathways for PRKCA (see all 41)
        TOR signaling
    Myometrial Relaxation and Contraction Pathways
    Keap1-Nrf2 Pathway
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway


    5/60        Reactome Pathways for PRKCA (see all 60)
        Signaling by EGFR in Cancer
    EGFR Transactivation by Gastrin
    Visual phototransduction
    G alpha (z) signalling events
    Stabilization of mRNA by HuR

    4 PharmGKB Pathways for PRKCA
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/48         Kegg Pathways  (Kegg details for PRKCA) (see all 48):
        MAPK signaling pathway
    ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Phosphatidylinositol signaling system


    PRKCA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/382 Interacting proteins for PRKCA (P172521, 2, 3 ENSP000002843844) via UniProtKB, MINT, STRING, and/or I2D (see all 382)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IEA--
    GO:0001525angiogenesis IEA--
    GO:0001933negative regulation of protein phosphorylation ----
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0001938positive regulation of endothelial cell proliferation IMP11909826

    PRKCA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCA for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCA:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCA

    Compounds for PRKCA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    10/970 HMDB Compounds for PRKCA (see all 970)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    4 DrugBank Compounds for PRKCA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 9430404 17016423 11850093 11736999
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--16114872 17367165 14698304 12269833
    Ellagic Acid-- 476-66-4targetinhibitor, competitive9581512
    Ingenol Mebutate 3-Ingenyl Angelate (see all 4)75567-37-2targetligand15126366

    10/120 Novoseek inferred chemical compound relationships for PRKCA gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 89.3 33 12954613 (2), 11196412 (1), 9117107 (1), 17784814 (1) (see all 24)
    go 6976 88.1 34 15313909 (2), 15240825 (1), 17988665 (1), 15067074 (1) (see all 25)
    phorbol 82.4 42 8627336 (2), 9150270 (2), 16460753 (2), 2171516 (1) (see all 36)
    rottlerin 82.4 15 18227124 (1), 11018530 (1), 14975703 (1), 15591124 (1) (see all 13)
    bryostatin 1 81 60 9058599 (6), 8702857 (5), 9815959 (4), 10825394 (3) (see all 22)
    2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 80.4 8 10930535 (5), 12372800 (1)
    affinitak 80.4 3 12722024 (2), 14662029 (1)
    12-o-tetradecanoylphorbol 13-acetate 80 152 10825394 (4), 8848016 (4), 14596936 (4), 10638963 (4) (see all 60)
    bisindolylmaleimide 78.8 6 12438545 (1), 10625951 (1), 18774710 (1), 10529207 (1) (see all 5)
    thymeleatoxin 78 6 11278894 (1), 12562561 (1), 8454058 (1), 9334226 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCA / KPCA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKCA gene: 
    NM_002737.2  

    Unigene Clusters for PRKCA:

    Protein kinase C, alpha
    Hs.531704  [show with all ESTs], Hs.708867  [show with all ESTs]
    Unigene Representative Sequences: NM_002737, AK055431
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578063 ENST00000583361 ENST00000413366(uc002jfp.1) ENST00000284384(uc002jfo.1)
    ENST00000583775
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCA
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRKCA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCA
    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCA (see all 5)
    OriGene ORF clones in mouse, rat for PRKCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA
    Sirion Biotech Customized lentivirus for stable overexpression of PRKCA 
                         Customized lentivirus expression plasmids for stable overexpression of PRKCA 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCA

    Additional mRNA sequence: AK055431.1 

    6 DOTS entries:

    DT.92057236  DT.100008326  DT.95146978  DT.112772  DT.99952496  DT.100752140 

    24/199 AceView cDNA sequences (see all 199):

    AI393766 AI378421 AI333003 BQ639130 AL119889 BX090601 AI922052 M22199 
    BQ010062 CA405605 AA693859 CA432244 AA235234 AI167582 AW472785 AL702506 
    BX648954 AW014963 BX645282 AI452891 NM_002737 BM463848 AA346795 AK125425 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                            -     -                                                         
    SP2:                                                                                                            


    ECgene alternative splicing isoforms for PRKCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCA expression in normal human tissues (normalized intensities)      PRKCA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACGCTTTG
    PRKCA Expression
    About this image


    PRKCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Root Ganglion   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus

    See PRKCA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCA

    SOURCE GeneReport for Unigene clusters: Hs.531704 Hs.708867
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCA (see all 19): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKCA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PRKCA gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkca1 , 5 protein kinase C, alpha1, 5 91.02(n)1
    99.55(a)1
      11 (70.80 cM)5
    187501  NM_011101.31  NP_035231.21 
     1079333875 
    chicken
    (Gallus gallus)
    Aves PRKCA1 protein kinase C, alpha 83.28(n)
    94.48(a)
      417430  NM_001012804.1  NP_001012822.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCA6
    protein kinase C, alpha
    88(a)
    1 ↔ 1
    GL343260.1(67393-258683)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.149762 Xenopus laevis transcribed sequence with strong similarity more 80.21(n)    BJ031632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkca1 protein kinase C, alpha 75.1(n)
    85.3(a)
      497384  XM_002662404.1  XP_002662450.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc53E1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Protein C kinase 53E1
    70(a)
    (best of 2)3
    66.88(n)1
    70.75(a)1
      53E23
    483111  NM_166201.21  NP_725626.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-23 Protein kinase C 68(a)   X(9414106-9420963)   --


    ENSEMBL Gene Tree for PRKCA (if available)
    TreeFam Gene Tree for PRKCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCA gene
    ENSG000002589892  PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCZ2  
    PRKCD2  PKN32  PRKCG2  PKN22  
    18/55 SIMAP similar genes for PRKCA using alignment to 6 protein entries:     KPCA_HUMAN (see all proteins) (see all similar genes):
    PRKCB    PRKCG    PRKD2    PRKD1    PRKCH    RPH3A
    AKT1    RPS6KA2    RPS6KA3    DOC2A    KIN27    PRKACB
    PRKCI    AKT3    MARK4    PRKCE    PRKCZ    PRKACG

    PRKCA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11064 SNPs in PRKCA are shown (see all 11064)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423024
    A glioblastoma multiforme sample4--see VAR_0423022 D N mis40--------
    VAR_0423014
    A colorectal adenocarcinoma sample4--see VAR_0423012 P S mis40--------
    VAR_0505584
    ----see VAR_0505582 V I mis40--------
    rs617623721,2
    C,F--64298682(+) TCCGGG/ACCGCC 1 -- us2k13Minor allele frequency- A:0.36NS EU 92
    rs617623731,2
    C,F--64298782(+) GCTCCC/TGCTCC 1 -- us2k12Minor allele frequency- T:0.04NS 56
    rs58215331,2
    C--64299621(-) CCCCCC/-ACCCC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs58215321,2
    C--64299622(-) CACAAC/-CCCCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs58215311,2
    C--64301000(-) TGACCACC/-TCCTC 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs595829781,2
    C--64303972(+) CTTCT-/CTTTTCC 1 -- int10--------
    rs113938121,2
    C--64304514(+) TTTTTT/-CAAAT 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for PRKCA (64298754 - 64548754 bp, first 250kb of PRKCA)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for PRKCA (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716120CNV Deletion23290073
    esv2160844CNV Deletion18987734
    esv2716118CNV Deletion23290073
    esv2716119CNV Deletion23290073
    esv2716121CNV Deletion23290073
    esv2716116CNV Deletion23290073
    esv2675034CNV Deletion23128226
    nsv2126CNV Insertion18451855
    esv274427CNV Insertion20981092
    esv272620CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCA
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176960    OMIM disorders: --

    20/110 diseases for PRKCA (see all 110):    About MalaCards
    pituitary tumors    myofibrillar myopathy    membranous glomerulonephritis    myxoid chondrosarcoma
    bacterial vaginosis    blastoma    familial hypertrophic cardiomyopathy    hypertrophic cardiomyopathy
    thymoma    appendicitis    bladder transitional cell carcinoma    colon adenocarcinoma
    leiomyoma    chondrosarcoma    insulinoma    hepatopulmonary syndrome
    cholesteatoma    ovarian cancer    bladder carcinoma    bipolar disorder


    PRKCA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for PRKCA gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 42.3 35 7595754 (5), 9676858 (4), 10848585 (2), 11170840 (2) (see all 18)
    erythroleukemia 37.2 3 9925750 (2), 9685375 (1)
    tumors 32.8 108 16008942 (5), 15930268 (3), 15922420 (3), 14966210 (2) (see all 62)
    breast carcinoma 28.2 14 14966210 (2), 9146728 (2), 9284950 (2), 9563854 (1) (see all 9)
    melanoma 24.5 57 12839565 (10), 15057036 (5), 20216103 (5), 11894137 (3) (see all 14)
    colon cancer 23.5 19 9547673 (4), 20141613 (4), 19232344 (2), 19417139 (1) (see all 8)
    breast cancer 23.4 64 16407820 (4), 20398285 (3), 11371124 (3), 11525643 (3) (see all 29)
    glioblastoma 23 15 7838340 (4), 7931620 (1), 10628339 (1), 15701280 (1) (see all 6)
    cancer 21.6 36 16407820 (3), 15531915 (2), 20153162 (2), 15180529 (2) (see all 23)
    prostate cancer 18.6 29 12497586 (3), 19029835 (2), 16979586 (2), 10825394 (1) (see all 19)

    Genetic Association Database (GAD): PRKCA
    Human Genome Epidemiology (HuGE) Navigator: PRKCA (18 documents)

    Export disorders for PRKCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCA gene, integrated from 9 sources (see all 1467):
    (articles sorted by number of sources associating them with PRKCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. (PubMed id 18056764)1, 2, 9 Xu H....Li H. (2008)
    2. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. (PubMed id 15155525)1, 4, 9 Barton A....Worthington J. (2004)
    3. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. (PubMed id 10848585)1, 2, 9 Besson A. and Yong V.W. (2000)
    4. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. (PubMed id 9738012)1, 2, 9 Ruvolo P.P....May W.S. (1998)
    5. Evidence of a gene-environment interaction that predi sposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosi s and DNA variants in genes that control the inflammatory response. (PubMed id 20350647)1, 4, 9 GA^mez L.M....Parry S. (2010)
    6. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. (PubMed id 15504744)1, 2, 9 Makagiansar I.T.... Stallcup W.B. (2004)
    7. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. (PubMed id 11909826)1, 2, 9 Wang A....Ware J.A. (2002)
    8. Genome-wide association study of body height in Africa n Americans: the Women's Health Initiative SNP Health Association Resource (SHAR e). (PubMed id 22021425)1, 4 Carty C.L....Kooperberg C. (2012)
    9. Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. (PubMed id 21576361)1, 2 Dobrikov M.... Gromeier M. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5578 HGNC: 9393 AceView: PRKCA Ensembl:ENSG00000154229 euGenes: HUgn5578
    ECgene: PRKCA Kegg: 5578 H-InvDB: PRKCA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKCA gene:
    Search GeneIP for patents involving PRKCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCA
     EMD Millipore Purified and/or Recombinant PRKCA Protein
     EMD Millipore small molecules (inhibitor) for PRKCA
     EMD Millipore Kits and Assays for the Analysis of PRKCA
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PRKCA (PKC alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRKCA   OriGene RNAi products in human, mouse, rat for PRKCA  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PRKCA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRKCA  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRKCA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRKCA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKCA   OriGene Custom Protein Services for PRKCA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKCA
     QIAGEN SeqTarget long-range PCR primers for resequencing PRKCA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKCA
     GenScript Custom Purified and Recombinant Proteins Services for PRKCA GenScript cDNA clones with any tag delivered in your preferred vector for PRKCA
     GenScript PRKCA-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for PRKCA
     GenScript Custom overexpressing Cell Line Services for PRKCA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PRKCA  (PKCA)

     Regulatory tfbs in PRKCA promoter
     Search Chromatin IP Primers for PRKCA
     RT2 qPCR Primer Assay in human, mouse, rat PRKCA
     GNC Network for PRKCA
     SABiosciences PCR Arrays including human, mouse, rat PRKCA
     Tocris compounds for PRKCA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRKCA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for PRKCA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRKCA antibodies
     PRKCA proteins
     PRKCA lysates
     Antibodies for PRKCA
     See all of Abcam's Antibodies, Kits and Proteins for PRKCA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PRKCA




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PRKCA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PRKCA
     SwitchGear Promoter luciferase reporter plasmids for PRKCA
     ThermoFisher Antibody for PRKCA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKCA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKCA
     Validated adenovirus to knockdown PRKCA (PKC-alpha) in human, mouse

    Customized:
     lentivirus for stable overexpression of PRKCA
     lentivirus expression plasmids for stable overexpression of PRKCA
     adenovirus for overexpression of PRKCA
     LSBio Antibodies in human, mouse, rat for PRKCA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRKCA gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4