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Aliases for PRKCA Gene

Aliases for PRKCA Gene

  • Protein Kinase C Alpha 2 3
  • Protein Kinase C, Alpha 2 3 5
  • EC 2.7.11.13 4 63
  • PKC-Alpha 3 4
  • PRKACA 3 4
  • PKC-A 3 4
  • PKCA 3 4
  • Aging-Associated Gene 6 3
  • EC 2.7.11 63
  • AAG6 3

External Ids for PRKCA Gene

Previous HGNC Symbols for PRKCA Gene

  • PKCA

Previous GeneCards Identifiers for PRKCA Gene

  • GC17M063614
  • GC17M066678
  • GC17P064716
  • GC17P064849
  • GC17P061729
  • GC17P064298
  • GC17P059689

Summaries for PRKCA Gene

Entrez Gene Summary for PRKCA Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCA Gene

PRKCA (Protein Kinase C Alpha) is a Protein Coding gene. Diseases associated with PRKCA include Glioma and Glioblastoma. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCA Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Tocris Summary for PRKCA Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCA Gene

Genomics for PRKCA Gene

Regulatory Elements for PRKCA Gene

Enhancers for PRKCA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRKCA on UCSC Golden Path with GeneCards custom track

Promoters for PRKCA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCA on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKCA Gene

Chromosome:
17
Start:
66,302,636 bp from pter
End:
66,810,744 bp from pter
Size:
508,109 bases
Orientation:
Plus strand

Genomic View for PRKCA Gene

Genes around PRKCA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCA Gene

Proteins for PRKCA Gene

  • Protein details for PRKCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17252-KPCA_HUMAN
    Recommended name:
    Protein kinase C alpha type
    Protein Accession:
    P17252
    Secondary Accessions:
    • B5BU22
    • Q15137
    • Q32M72
    • Q96RE4

    Protein attributes for PRKCA Gene

    Size:
    672 amino acids
    Molecular mass:
    76750 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and RACK1 (By similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. Interacts with PICK1 (via PDZ domain). Interacts with TRIM41.

    Three dimensional structures from OCA and Proteopedia for PRKCA Gene

neXtProt entry for PRKCA Gene

Proteomics data for PRKCA Gene at MOPED

Post-translational modifications for PRKCA Gene

  • Ubiquitination at Lys 621 and Lys 628
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCA (PKCA)

Domains & Families for PRKCA Gene

Suggested Antigen Peptide Sequences for PRKCA Gene

Graphical View of Domain Structure for InterPro Entry

P17252

UniProtKB/Swiss-Prot:

KPCA_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCA: view

Function for PRKCA Gene

Molecular function for PRKCA Gene

GENATLAS Biochemistry:
protein kinase C,alpha polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCA Gene

Gene Ontology (GO) - Molecular Function for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004697 protein kinase C activity IEA,TAS --
GO:0035403 histone kinase activity (H3-T6 specific) IDA 20228790
genes like me logo Genes that share ontologies with PRKCA: view
genes like me logo Genes that share phenotypes with PRKCA: view

Human Phenotype Ontology for PRKCA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKCA Gene

MGI Knock Outs for PRKCA:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PRKCA Gene

Localization for PRKCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCA Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCA Gene COMPARTMENTS Subcellular localization image for PRKCA gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytoskeleton 3
endosome 2
golgi apparatus 2
lysosome 2
vacuole 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031966 mitochondrial membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRKCA: view

Pathways & Interactions for PRKCA Gene

SuperPathways for PRKCA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 DAG and IP3 signaling
3 IL-2 Pathway
4 Circadian entrainment
5 fMLP Pathway
genes like me logo Genes that share pathways with PRKCA: view

Pathways by source for PRKCA Gene

Gene Ontology (GO) - Biological Process for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002159 desmosome assembly IMP 18474624
GO:0006112 energy reserve metabolic process TAS --
GO:0006468 protein phosphorylation IEA,IDA 10770950
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with PRKCA: view

Drugs & Compounds for PRKCA Gene

(87) Drugs for PRKCA Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidylserine Approved Nutra Target 0
Vitamin E Approved Nutra Target 382,385
Ingenol Mebutate Approved Pharma Target, ligand 0
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 364
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 396

(193) Additional Compounds for PRKCA Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCA Gene

Compound Action Cas Number
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
PKC fragment (530-558) Potent activator of protein kinase C 122613-29-0
Pseudo RACK1 Protein kinase C activator peptide (attached to cell permeable vector)
SC-10 Protein kinase C activator 102649-79-6
SC-9 Protein kinase C activator 102649-78-5

(13) ApexBio Compounds for PRKCA Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCA: view

Drug Products

Transcripts for PRKCA Gene

Unigene Clusters for PRKCA Gene

Protein kinase C, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:

Relevant External Links for PRKCA Gene

GeneLoc Exon Structure for
PRKCA
ECgene alternative splicing isoforms for
PRKCA

Expression for PRKCA Gene

mRNA expression in normal human tissues for PRKCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKCA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCA Gene



SOURCE GeneReport for Unigene cluster for PRKCA Gene Hs.531704

genes like me logo Genes that share expression patterns with PRKCA: view

Protein tissue co-expression partners for PRKCA Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKCA Gene

Orthologs for PRKCA Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKCA 35
  • 88.1 (n)
  • 97.77 (a)
PRKCA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCA 35
  • 92.16 (n)
  • 99.34 (a)
PRKCA 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkca 35
  • 91.02 (n)
  • 99.55 (a)
Prkca 16
Prkca 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCA 35
  • 99.55 (n)
  • 99.85 (a)
PRKCA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkca 35
  • 91.35 (n)
  • 99.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCA 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCA 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCA 35
  • 83.23 (n)
  • 94.2 (a)
-- 36
  • 91 (a)
OneToMany
PRKCA 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRKCA 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkca 35
  • 79.42 (n)
  • 91.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14976 35
zebrafish
(Danio rerio)
Actinopterygii prkca 35
  • 74.94 (n)
  • 85.11 (a)
prkca 36
  • 85 (a)
OneToMany
PRKCA (2 of 3) 36
  • 82 (a)
OneToMany
PRKCA (3 of 3) 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta inaC 37
  • 52 (a)
Pkc53E 37
  • 70 (a)
Pkc53E 35
  • 66.88 (n)
  • 70.75 (a)
inaC 36
  • 48 (a)
ManyToMany
Pkc53E 36
  • 66 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012252 35
  • 65.57 (n)
  • 69.54 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-2 37
  • 68 (a)