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PRKCA Gene

protein-coding   GIFtS: 75
GCID: GC17P064298

Protein Kinase C, Alpha


(Previous symbol: PKCA)
  See PRKCA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase C, Alpha1 2     EC 2.7.11.133 8
PKCA1 2 3 5     AAG62
PKC-A2 3     Aging-Associated Gene 62
PKC-alpha2 3     Protein Kinase C Alpha Type2
PRKACA2 3     EC 2.7.118

External Ids:    HGNC: 93931   Entrez Gene: 55782   Ensembl: ENSG000001542297   OMIM: 1769605   UniProtKB: P172523   

Export aliases for PRKCA gene to outside databases

Previous GC identifers: GC17M063614 GC17M066678 GC17P064716 GC17P064849 GC17P061729 GC17P059689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKCA Gene:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by
calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein
targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as
major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific
expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of
the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as
cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice
suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PRKCA Gene:
PRKCA (protein kinase C, alpha) is a protein-coding gene. Diseases associated with PRKCA include pituitary tumor, invasive. GO annotations related to this gene include protein kinase C activity and enzyme binding. An important paralog of this gene is PRKCQ.

UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
(ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation
of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation
of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent
kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can
trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated
growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic
function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of
IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage
differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is
associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and
participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4,
which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell
accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a
tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers.
Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and
thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a
MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte
hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface
area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial
contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN),
and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube
formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced
cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4
receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for
adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions
involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate
NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon
stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1
binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to
inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating
transcription

summary for PRKCA Gene:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCA (PKC alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKCA gene promoter:
         GR   STAT1   AP-1   GR-beta   IRF-1   CREB   IRF-2   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCA promoter sequence
   Search Chromatin IP Primers for PRKCA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q22-q24

PRKCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P064298:  view genomic region     (about GC identifiers)

Start:
64,298,754 bp from pter      End:
64,806,862 bp from pter
Size:
508,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252 (See protein sequence)
Recommended Name: Protein kinase C alpha type  
Size: 672 amino acids; 76750 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity)
Subunit: Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1 (By
similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Interacts with PICK1 (via PDZ domain). Interacts with TRIM41
3 PDB 3D structures from and Proteopedia for PRKCA:
2ELI (3D)        3IW4 (3D)        4DNL (3D)    
Secondary accessions: B5BU22 Q15137 Q32M72 Q96RE4

Explore the universe of human proteins at neXtProt for PRKCA: NX_P17252

Explore proteomics data for PRKCA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys76, Lys388, Lys621, Lys628
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKCA (P17252) (see all 50)
     VNGGDLM  GTEELYA  VRDAKNL  FFRRIDW 


    See PRKCA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002728.1  
    ENSEMBL proteins: 
     ENSP00000462087   ENSP00000408695   ENSP00000284384  
    Reactome Protein details: P17252

    PRKCA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKCA Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCA
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRKCA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRKCA
    GenScript Custom Purified and Recombinant Proteins Services for PRKCA
    Novus Biologicals PRKCA Proteins
    Novus Biologicals PRKCA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRKCA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKCA 

    PRKCA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCA
    R&D Systems Antibodies for PRKCA (PKC alpha)
    Cell Signaling Technology (CST) Antibodies for PRKCA  (PKCA)
    OriGene Antibodies for PRKCA
    OriGene Custom Antibody Services for PRKCA
    Novus Biologicals PRKCA Antibodies
    Abcam antibodies for PRKCA (Q02156, P17252, P05129, Q05655, Q05513, P05771, Q32M72)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PRKCA
    LSBio Antibodies in human, mouse, rat for PRKCA

    PRKCA Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PRKCA
    OriGene Custom Assay Services for PRKCA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKCA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PRKCA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase C, alpha
    Delta subfamily
    Protein kinase C

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P17252

    ProtoNet protein and cluster: P17252

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKCA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KPCA_HUMAN, P17252
    Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that
    is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
    adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
    phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
    (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation
    of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation
    of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent
    kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can
    trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated
    growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic
    function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of
    IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage
    differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is
    associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and
    participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4,
    which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell
    accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a
    tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers.
    Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and
    thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a
    MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte
    hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface
    area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
    significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial
    contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN),
    and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube
    formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced
    cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4
    receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for
    adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions
    involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate
    NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon
    stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1
    binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to
    inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating
    transcription
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and
    diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the
    kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full
    activation

         Genatlas biochemistry entry for PRKCA:
    protein kinase C,alpha polypeptide

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004697protein kinase C activity ISS--
    GO:0004698calcium-dependent protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with PRKCA           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for PRKCA:
     Decreased focal adhesion (FA)   Gemcitabine induced cell-death  Increased cell death HMECs cel  Increased colony dispersion (i 
     Increases Tamoxifen sensitivit 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkca):
     adipose tissue  cardiovascular system  homeostasis/metabolism  integument  muscle 
     nervous system  tumorigenesis 

    Find genes that share phenotypes with PRKCA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKCA: Prkcatm1Cda Prkcatm1Far Prkcatm1Jmk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKCA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKCA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKCA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKCA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKCA:
    hsa-mir-505-3p (MIRT040995), hsa-mir-17-3p (MIRT050756), mmu-mir-24-2-5p (MIRT006882), hsa-mir-92a-3p (MIRT049636), hsa-mir-193b-3p (MIRT041382), hsa-mir-375 (MIRT020045)

    Block miRNA regulation of human, mouse, rat PRKCA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKCA
    Predesigned siRNA for gene silencing in human, mouse, rat PRKCA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKCA

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKCA (see all 6)
    OriGene ORF clones in mouse, rat for PRKCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
    Sino Biological Human cDNA Clone for PRKCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA
    Addgene plasmids for PRKCA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKCA
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKCA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KPCA_HUMAN, P17252: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral
    membrane protein (Probable). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus5
    plasma membrane5
    endoplasmic reticulum4

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with PRKCA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKCA About   (see all 154)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    Development Angiotensin signaling via beta Arrestin0.39
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    4Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.67
    PLC-gamma1 signalling0.94
    G-protein mediated events0.65
    CaM pathway0.93
    Phospholipase C-mediated cascade0.59
    5fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42


    Find genes that share SuperPaths with PRKCA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for PRKCA
        Wnt Signaling Pathways
    Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKCA (see all 83)
        Fc-GammaR Pathway
    Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCA
        Ca, cAMP and Lipid Signaling

    5 Tocris Bioscience Pathways for PRKCA
        Insulin Pathway
    NF-kappaB Pathway
    VEGF Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKCA (see all 24)
        Development FGF-family signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development VEGF-family signaling

    Selected BioSystems Pathways for PRKCA (see all 42)
        Myometrial Relaxation and Contraction Pathways
    Keap1-Nrf2 Pathway
    TOR signaling
    EGFR1 Signaling Pathway
    Wnt Signaling Pathway


    Selected Reactome Pathways for PRKCA (see all 15)
        Depolymerisation of the Nuclear Lamina
    EGFR Transactivation by Gastrin
    Response to elevated platelet cytosolic Ca2+
    WNT5A-dependent internalization of FZD4
    G alpha (z) signalling events

    4 PharmGKB Pathways for PRKCA
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PRKCA) (see all 54):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCA (see all 19): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKCA (P172521, 2, 3 ENSP000002843844) via UniProtKB, MINT, STRING, and/or I2D (see all 459)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 61):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IEA--
    GO:0001525angiogenesis IEA--
    GO:0001933negative regulation of protein phosphorylation ----
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0001938positive regulation of endothelial cell proliferation IMP11909826

    Find genes that share ontologies with PRKCA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PRKCA
    10 ApexBio Compounds for PRKCA     About this table
    CompoundAction CAS #
    CX-4945 (Silmitasertib)potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor[1009820-21-6]
    Dequalinium ChloridePKC inhibitor[522-51-0]
    Enzastaurin (LY317615)potent PKC beta inhibitor[170364-57-5]
    GF 109203XVery potent and selective inhibitor of PKC[133052-90-1]
    Go 6976PKC inhibitor[136194-77-9]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    K-252cPKC inhibitor[85753-43-1]
    Ro 31-8220cell-permeable inhibitor of PKC[125314-64-9]
    Sotrastaurin (AEB071)Potent and specific inhibitor of PKC[425637-18-9]
    Staurosporine (CGP 41251)inhibitor of a broad spectrum of protein kinases[62996-74-1]

    Compounds for PRKCA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Phorbol 12-myristate 13-acetateProtein kinase C activator[16561-29-8]
    ZIPCell-permeable inhibitor of atypical PKC isozyme PKMzeta[863987-12-6]
    Go 6983Broad spectrum PKC inhibitor[133053-19-7]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]

    Selected HMDB Compounds for PRKCA (see all 970)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    4 DrugBank Compounds for PRKCA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 9430404 17016423 11850093 11736999
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--16114872 17367165 14698304 12269833
    Ellagic Acid-- 476-66-4targetinhibitor, competitive9581512
    Ingenol Mebutate 3-Ingenyl Angelate (see all 4)75567-37-2targetligand15126366

    Selected Novoseek inferred chemical compound relationships for PRKCA gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 89.3 33 12954613 (2), 11196412 (1), 9117107 (1), 17784814 (1) (see all 24)
    go 6976 88.1 34 15313909 (2), 15240825 (1), 17988665 (1), 15067074 (1) (see all 25)
    phorbol 82.4 42 8627336 (2), 9150270 (2), 16460753 (2), 2171516 (1) (see all 36)
    rottlerin 82.4 15 18227124 (1), 11018530 (1), 14975703 (1), 15591124 (1) (see all 13)
    bryostatin 1 81 60 9058599 (6), 8702857 (5), 9815959 (4), 10825394 (3) (see all 22)
    2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 80.4 8 10930535 (5), 12372800 (1)
    affinitak 80.4 3 12722024 (2), 14662029 (1)
    12-o-tetradecanoylphorbol 13-acetate 80 152 10825394 (4), 8848016 (4), 14596936 (4), 10638963 (4) (see all 60)
    bisindolylmaleimide 78.8 6 12438545 (1), 10625951 (1), 18774710 (1), 10529207 (1) (see all 5)
    thymeleatoxin 78 6 11278894 (1), 12562561 (1), 8454058 (1), 9334226 (1)

    1 PharmGKB related drug/compound annotation for PRKCA gene    About this table
    Drug/compound PharmGKB Annotation
    hydrochlorothiazideCA  



    Find genes that share compounds with PRKCA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PRKCA gene: 
    NM_002737.2  

    Unigene Cluster for PRKCA:

    Protein kinase C, alpha
    Hs.531704  [show with all ESTs]
    Unigene Representative Sequence: NM_002737
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578063 ENST00000583361 ENST00000413366(uc002jfp.1) ENST00000284384(uc002jfo.1)
    ENST00000583775
    miRNA
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    Block miRNA regulation of human, mouse, rat PRKCA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
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    OriGene ORF clones in mouse, rat for PRKCA
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    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
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    Addgene plasmids for PRKCA 
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      QuantiFast Probe-based Assays in human, mouse, rat PRKCA

    Additional mRNA sequence: 

    AB209475.1 AB451258.1 AB451383.1 AF035594.1 AF035595.1 AF086287.1 AK125425.1 AY633609.1 
    BC015855.1 BC053321.1 BC062759.1 BC071767.1 BC101403.1 BC103691.1 BC107592.1 BC109273.1 
    BC109274.1 BC122530.1 BX648954.1 M22199.1 X52479.1 

    6 DOTS entries:

    DT.92057236  DT.100008326  DT.95146978  DT.112772  DT.99952496  DT.100752140 

    Selected AceView cDNA sequences (see all 199):

    AK125425 AI393766 BU726162 BQ650650 AL119889 BX090601 AW270723 AI922052 
    AI371754 BX648954 AI567496 AA059219 BQ639130 R93247 BF932780 AW014963 
    BX645282 AI452891 AI435797 AW771547 BM463848 NM_002737 BQ010062 BQ651141 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                            -     -                                                         
    SP2:                                                                                                            


    ECgene alternative splicing isoforms for PRKCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKCA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACGCTTTG
    PRKCA Expression
    About this image


    PRKCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
    PRKCA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKCA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531704
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKCA (see all 19): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PRKCA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKCA
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    QuantiFast Probe-based Assays in human, mouse, rat PRKCA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRKCA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkca1 , 5 protein kinase C, alpha1, 5 91.02(n)1
    99.55(a)1
      11 (70.80 cM)5
    187501  NM_011101.31  NP_035231.21 
     1079333875 
    chicken
    (Gallus gallus)
    Aves PRKCA1 protein kinase C, alpha 83.23(n)
    94.2(a)
      417430  NM_001012804.1  NP_001012822.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKCA6
    protein kinase C, alpha
    88(a)
    1 ↔ 1
    GL343260.1(67393-258683)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.149762 Xenopus laevis transcribed sequence with strong similarity more 80.21(n)    BJ031632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkca1 protein kinase C, alpha 74.94(n)
    85.11(a)
      497384  NM_001256241.1  NP_001243170.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkc53E1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    Protein C kinase 53E1
    70(a)
    (best of 2)3
    66.88(n)1
    70.75(a)1
      53E23
    483111  NM_166201.31  NP_725626.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pkc-21 , 3 Protein kinase C3
    pkc-21
    68(a)3
    64.6(n)1
    70.65(a)1
      X(9414106-9420963)3
    1811661  NM_001029347.11  NP_001024518.11 


    ENSEMBL Gene Tree for PRKCA (if available)
    TreeFam Gene Tree for PRKCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKCA gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCZ2  PRKCD2  
    PKN32  PRKCG2  PKN22  
    Selected SIMAP similar genes for PRKCA using alignment to 6 protein entries:     KPCA_HUMAN (see all proteins) (see all similar genes):
    PRKCB    PRKCG    PRKD2    PRKD1    PRKCH    AKT1
    RPS6KA2    RPS6KA3    DOC2A    KIN27    PRKACB    PRKCI
    AKT3    MARK4    PRKCE    PRKCZ    PRKACG    PRKACA

    Find genes that share paralogs with PRKCA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKCA (see all 11064)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423024
    A glioblastoma multiforme sample4--see VAR_0423022 D N mis40--------
    VAR_0423014
    A colorectal adenocarcinoma sample4--see VAR_0423012 P S mis40--------
    rs617623721,2
    C,F--64298682(+) TCCGGG/ACCGCC 1 -- us2k13Minor allele frequency- A:0.36NS EU 92
    rs617623731,2
    C,F--64298782(+) GCTCCC/TGCTCC 1 -- us2k12Minor allele frequency- T:0.04NS 56
    rs58215331,2
    C--64299621(-) CCCCCC/-ACCCC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs58215321,2
    C--64299622(-) CACAAC/-CCCCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs58215311,2
    C--64301000(-) TGACCACC/-TCCTC 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs595829781,2
    C--64303972(+) CTTCT-/CTTTTCC 1 -- int10--------
    rs113938121,2
    C--64304514(+) TTTTTT/-CAAAT 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs567558411,2
    C--64305006(+) TTTTGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for PRKCA (64298754 - 64548754 bp, first 250kb of PRKCA)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKCA (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716120CNV Deletion23290073
    esv2160844CNV Deletion18987734
    esv2716118CNV Deletion23290073
    esv2716119CNV Deletion23290073
    esv2716121CNV Deletion23290073
    esv2716116CNV Deletion23290073
    esv2675034CNV Deletion23128226
    nsv2126CNV Insertion18451855
    esv274427CNV Insertion20981092
    esv272620CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKCA
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176960    OMIM disorders: --

    1 disease for PRKCA:    
    About MalaCards
    pituitary tumor, invasive


    Find genes that share disorders with PRKCA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKCA gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 42.3 35 7595754 (5), 9676858 (4), 10848585 (2), 11170840 (2) (see all 18)
    erythroleukemia 37.2 3 9925750 (2), 9685375 (1)
    tumors 32.8 108 16008942 (5), 15930268 (3), 15922420 (3), 14966210 (2) (see all 62)
    breast carcinoma 28.2 14 14966210 (2), 9146728 (2), 9284950 (2), 9563854 (1) (see all 9)
    melanoma 24.5 57 12839565 (10), 15057036 (5), 20216103 (5), 11894137 (3) (see all 14)
    colon cancer 23.5 19 9547673 (4), 20141613 (4), 19232344 (2), 19417139 (1) (see all 8)
    breast cancer 23.4 64 16407820 (4), 20398285 (3), 11371124 (3), 11525643 (3) (see all 29)
    glioblastoma 23 15 7838340 (4), 7931620 (1), 10628339 (1), 15701280 (1) (see all 6)
    cancer 21.6 36 16407820 (3), 15531915 (2), 20153162 (2), 15180529 (2) (see all 23)
    prostate cancer 18.6 29 12497586 (3), 19029835 (2), 16979586 (2), 10825394 (1) (see all 19)

    Genetic Association Database (GAD): PRKCA
    Human Genome Epidemiology (HuGE) Navigator: PRKCA (18 documents)

    Export disorders for PRKCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKCA gene, integrated from 10 sources (see all 1491):
    (articles sorted by number of sources associating them with PRKCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. (PubMed id 18056764)1, 2, 9 Xu H.... Li H. (Cardiovasc. Res. 2008)
    2. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. (PubMed id 15155525)1, 4, 9 Barton A....Worthington J. (Brain 2004)
    3. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. (PubMed id 10848585)1, 2, 9 Besson A. and Yong V.W. (Mol. Cell. Biol. 2000)
    4. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. (PubMed id 9738012)1, 2, 9 Ruvolo P.P.... May W.S. (J. Biol. Chem. 1998)
    5. Evidence of a gene-environment interaction that predisposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosis and DNA variants in genes that control the inflammatory response. (PubMed id 20350647)1, 4, 9 GA^mez L.M....Parry S. (Am. J. Obstet. Gynecol. 2010)
    6. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. (PubMed id 15504744)1, 2, 9 Makagiansar I.T.... Stallcup W.B. (J. Biol. Chem. 2004)
    7. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. (PubMed id 11909826)1, 2, 9 Wang A.... Ware J.A. (Circ. Res. 2002)
    8. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PubMed id 22021425)1, 4 Carty C.L....Kooperberg C. (Hum. Mol. Genet. 2012)
    9. Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. (PubMed id 21576361)1, 2 Dobrikov M.... Gromeier M. (Mol. Cell. Biol. 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5578 HGNC: 9393 AceView: PRKCA Ensembl:ENSG00000154229 euGenes: HUgn5578
    ECgene: PRKCA Kegg: 5578 H-InvDB: PRKCA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKCA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKCA gene:
    Search GeneIP for patents involving PRKCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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