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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKCA Gene

protein-coding   GIFtS: 73
GCID: GC17P064298

protein kinase C, alpha


(Previous symbol: PKCA)
 Explore 130 diseases affiliated with
PRKCA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKCA    

Aliases
for PRKCA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase C, Alpha1 2     EC 2.7.11.133 8
PKCA1 2 3 5     AAG62
PKC-A2 3     Aging-Associated Gene 62
PKC-Alpha1     Protein Kinase C Alpha Type2
PRKACA2 3     EC 2.7.118

External Ids:    HGNC: 93931   Entrez Gene: 55782   Ensembl: ENSG000001542297   OMIM: 1769605   UniProtKB: P172523   

Export aliases for PRKCA gene to outside databases

Previous GC identifers: GC17M063614 GC17M066678 GC17P064716 GC17P064849 GC17P061729 GC17P059689


Summaries
for PRKCA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKCA:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium
and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are
known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for
phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is
believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This
kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell
transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may
be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is
involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
(ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the
cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the
MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK)
complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle
arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1
and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects
them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates
anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage
colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After
wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion.
Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia
at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a
number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several
tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates
angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal
cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to
induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and
cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In
angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial
growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the
stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the
regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release,
and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to
lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and
inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through
IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with
12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be
involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity

summary for PRKCA:
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation
mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by
phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive
novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and
phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol
esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain
via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation
of multiple target proteins, which are involved in signal transduction pathways including, but not limited
to, receptor desensitization, modulation of membrane structure events, regulation of transcription,
regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCA (PKC alpha)


Genomic Views
for PRKCA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKCA gene promoter:
         GR   STAT1   AP-1   GR-beta   IRF-1   CREB   IRF-2   deltaCREB   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PRKCA promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKCA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22-q23.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q22-q24

PRKCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKCA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P064298:  view genomic region     (about GC identifiers)

Start:
 64,298,754 bp from pter      End:
 64,806,862 bp from pter
Size:
 508,109 bases      Orientation:
 plus strand

Proteins
for PRKCA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252 (See protein sequence)
Recommended Name: Protein kinase C alpha type  
Size: 672 amino acids; 76750 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity)
Subunit: Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1 (By
similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Interacts with PICK1 (via PDZ domain). Interacts with TRIM41
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral
membrane protein (Probable). Nucleus
3 PDB 3D structures from and Proteopedia for PRKCA:
2ELI (3D)        3IW4 (3D)        4DNL (3D)    
Secondary accessions: B5BU22 Q15137 Q32M72 Q96RE4

Explore the universe of human proteins at neXtProt for PRKCA: NX_P17252

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17252

    • 4/50 DME Specific Peptides for PRKCA (P17252) (see all 50)
     VNGGDLM  GTEELYA  VRDAKNL  FFRRIDW 

    PRKCA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002728.1  
    ENSEMBL proteins: 
     ENSP00000462087   ENSP00000408695   ENSP00000284384  
    Reactome Protein details: P17252
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PRKCA Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PRKCA
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PRKCA
    OriGene Custom Protein Services for PRKCA 
    GenScript Custom Purified and Recombinant Proteins Services for PRKCA
    Novus Biologicals PRKCA Proteins
    Novus Biologicals PRKCA Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRKCA
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0005624membrane fraction ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--


    PRKCA for ontologies           About GeneDecksing



    PRKCA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCA
    R&D Systems Antibodies for PRKCA (PKC alpha)
    Cell Signaling Technology (CST) Antibodies for PRKCA  (PKCA)
    OriGene Antibodies (see all 5): PRKCA
    OriGene Custom Antibody Services for PRKCA 
    GenScript Superior Antibodies for PRKCA
    Novus Biologicals PRKCA Antibodies
    Abcam antibodies for PRKCA 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for PRKCA

    Assay Products for PRKCA: 
    EMD Millipore Kits and Assays for the Analysis of PRKCA
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript PRKCA-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PRKCA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKCA for domains           About GeneDecksing

    5/14 InterPro domains/families (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry P17252

    ProtoNet protein and cluster: P17252

    3 Blocks protein families:
    IPB000008 C2 domain
    IPB000961 Protein kinase C-terminal domain
    IPB002219 Protein kinase C


    UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers
    Similarity: Contains 1 protein kinase domain


    Function
    for PRKCA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KPCA_HUMAN, P17252
    Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is
    involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and
    adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly
    phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3
    (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the
    cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the
    MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK)
    complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle
    arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1
    and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects
    them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates
    anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage
    colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After
    wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion.
    Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia
    at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a
    number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several
    tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates
    angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal
    cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to
    induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and
    cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces
    significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In
    angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial
    growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the
    stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the
    regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release,
    and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to
    lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and
    inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through
    IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with
    12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be
    involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and
    diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the
    kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full
    activation

         Genatlas biochemistry entry for PRKCA:
    protein kinase C,alpha polypeptide

    Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: PRKCA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCA
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCA (see all 6)
    OriGene siRNA: PRKCA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKCA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCA (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKCA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
    Sino Biological Human cDNA Clone for PRKCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRKCA
    Search LifeMap BioReagents cell lines for PRKCA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10770950
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004697protein kinase C activity TAS--
    GO:0004698calcium-dependent protein kinase C activity IEA--
    GO:0005515protein binding IPI--


    PRKCA for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PRKCA:
     Decreased focal adhesion (FA)   Gemcitabine induced cell-death  Increased cell death HMECs cel  Increased colony dispersion (i 
     Increases Tamoxifen sensitivit 

    Animal Models:
         Mouse knock-outs for PRKCA: Prkcatm1Cda Prkcatm1Far Prkcatm1Jmk
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Prkca):
     adipose tissue  cardiovascular system  homeostasis/metabolism  integument  muscle 
     nervous system  tumorigenesis 

    PRKCA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRKCA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/145 super-pathways (see all 145) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2ErbB4 Pathway
    8/11 pathways (see all 11)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		LPS Stimulated MAPK Signaling0.36
    		Prolactin Signaling0.54
    		VEGF Signaling Pathway0.35
    		ErbB2-ErbB3 Heterodimers0.47
    		Growth Hormone Signaling0.32
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4CCR3 Pathway in Eosinophils
    		CCR3 Pathway in Eosinophils1.00
    		CXCR4 Pathway0.39
    		VEGF and S-1P Signaling0.44
    		Alpha-Adrenergic Signaling0.31
    		fMLP Pathway0.43
    		Huntington's Disease Pathway0.18
    5Opioid Signalling
    		Opioid Signalling1.00
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    		G-protein mediated events0.55
    		Glutamatergic synapse0.31
    		PLC beta mediated events0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/23 EMD Millipore Pathways for PRKCA (see all 23)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Development A1 receptor signaling
    Immune response CCR3 signaling in eosinophils

    2 R&D Systems Pathways for PRKCA
        Wnt Signaling Pathway
    Adipocytokines & Insulin Signaling

    5/83 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKCA (see all 83)
        Fc-GammaR Pathway
    Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for PRKCA
        Ca, cAMP and Lipid Signaling

    5 Tocris Bioscience Pathways for PRKCA
        Insulin Pathway
    NF-kappaB Pathway
    VEGF Pathway
    MAPK Pathway
    mTOR Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for PRKCA (see all 24)
        Development FGF-family signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development VEGF-family signaling

    5/40 BioSystems Pathways for PRKCA (see all 40) 
        Keap1-Nrf2 Pathway
    AGE/RAGE pathway
    Signaling Pathways in Glioblastoma
    Myometrial Relaxation and Contraction Pathways
    ErbB signaling pathway

    5/54        Reactome Pathways for PRKCA (see all 54)
        Signaling by EGFR in Cancer
    EGFR Transactivation by Gastrin
    G alpha (z) signalling events
    Stabilization of mRNA by HuR
    Downstream signal transduction

    4 PharmGKB Pathways for PRKCA
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/33         Kegg Pathways  (Kegg details for PRKCA) (see all 33):
        MAPK signaling pathway
    ErbB signaling pathway
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Vascular smooth muscle contraction


    PRKCA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/371 Interacting proteins for PRKCA (P172521, 2, 3 ENSP000002843844) via UniProtKB, MINT, STRING, and/or I2D (see all 371)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/75 biological process terms (GO ID links to tree view) (see all 75):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IEA--
    GO:0000302response to reactive oxygen species ----
    GO:0001525angiogenesis IEA--
    GO:0001933negative regulation of protein phosphorylation ----
    GO:0001934positive regulation of protein phosphorylation IEA--


    PRKCA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKCA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKCA for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKCA:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PRKCA

    Compounds for PRKCA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Glu27]-PKC (19-36)Inactive control peptide for PKC (19-36) (Cat. No. 4058)[309247-49-2]
    Phorbol 12,13-dibutyrate Protein kinase C activator[37558-16-0]
    GF 109203XProtein kinase C inhibitor[133052-90-1]
    Go 6976Potent protein kinase C inhibitor; selective for alpha and beta isozymes[136194-77-9]
    PKC (19-36)Pseudosubstrate peptide; inhibitor of PKC[113731-96-7]

    10/970 HMDB Compounds for PRKCA (see all 970)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    2 DrugBank Compounds for PRKCA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin Ealpha-Tocopherol (see all 2)59-02-9target--17139284 9430404 17016423 11850093 11736999
    Phosphatidylserine3-O-sn-Phosphatidyl-L-serine (see all 3)8002-43-5target--16114872 17367165 14698304 12269833

    10/120 Novoseek chemical compound relationships for PRKCA gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 89.3 33 12954613 (2), 11196412 (1), 9117107 (1), 17784814 (1) (see all 24)
    go 6976 88.1 34 15313909 (2), 15240825 (1), 17988665 (1), 15067074 (1) (see all 25)
    phorbol 82.4 42 8627336 (2), 9150270 (2), 16460753 (2), 2171516 (1) (see all 36)
    rottlerin 82.4 15 18227124 (1), 11018530 (1), 14975703 (1), 15591124 (1) (see all 13)
    bryostatin 1 81 60 9058599 (6), 8702857 (5), 9815959 (4), 10825394 (3) (see all 22)
    2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 80.4 8 10930535 (5), 12372800 (1)
    affinitak 80.4 3 12722024 (2), 14662029 (1)
    12-o-tetradecanoylphorbol 13-acetate 80 152 10825394 (4), 8848016 (4), 14596936 (4), 10638963 (4) (see all 60)
    bisindolylmaleimide 78.8 6 12438545 (1), 10625951 (1), 18774710 (1), 10529207 (1) (see all 5)
    thymeleatoxin 78 6 11278894 (1), 12562561 (1), 8454058 (1), 9334226 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKCA / KPCA 

    Transcripts
    for PRKCA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKCA gene: 
    NM_002737.2  

    Unigene Clusters for PRKCA:

    Protein kinase C, alpha
    Hs.531704  [show with all ESTs], Hs.708867  [show with all ESTs]
    Unigene Representative Sequences: NM_002737, AK055431
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578063 ENST00000583361 ENST00000413366(uc002jfp.1) ENST00000284384(uc002jfo.1)
    ENST00000583775

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PRKCA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKCA
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKCA (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-485-3p hsa-miR-1260b hsa-miR-374a hsa-miR-3074-3p hsa-miR-550a* hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKCA (see all 6)
    OriGene siRNA: PRKCA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKCA
    Clone
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    GenScript: all cDNA clones in your preferred vector: PRKCA (NM_002737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKCA 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKCA

    Additional cDNA sequence: AK055431.1 

    6 DOTS entries:

    DT.92057236  DT.100008326  DT.95146978  DT.112772  DT.99952496  DT.100752140 

    24/199 AceView cDNA sequences (see all 199):

    AI378421 M22199 AL119889 AI922052 AI393766 AI333003 BQ639130 BX090601 
    R93247 AA235234 AA693859 AI167582 CA432244 AW472785 AL702506 BX648954 
    AI452891 BC062759 AW014963 NM_002737 AA346795 AK125425 BM463848 H83649 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                            -     -                                                         
    SP2:                                                                                                            


    ECgene alternative splicing isoforms for PRKCA

    Expression
    for PRKCA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKCA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACGCTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKCA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKCA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKCA

    SOURCE GeneReport for Unigene clusters: Hs.531704 Hs.708867
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKCA (see all 19): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cell Motility in human mouse rat
              Cancer Drug Targets in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKCA

    Orthologs
    for PRKCA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PRKCA gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRKCA1 protein kinase C, alpha 83.28(n)
    94.48(a)    		   417430  NM_001012804.1  NP_001012822.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PRKCA6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343260.1(67308-150726)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.149762 Xenopus laevis transcribed sequence with strong similarity more 80.21(n)    BJ031632.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii prkca1 protein kinase C, alpha 75.1(n)
    85.3(a)    		   497384  XM_002662404.1  XP_002662450.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pkc53E1 , 3 protein amino acid phosphorylation protein
    serine/threonine more3
    Protein C kinase 53E1    		 70(a)
    (best of 2)3
    66.88(n)1
    70.75(a)1    		   53E23
    483111  NM_166201.21  NP_725626.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea pkc-23 Protein kinase C 68(a)   X(9414106-9420963)   --


    ENSEMBL Gene Tree for PRKCA (if available)
    TreeFam Gene Tree for PRKCA (if available) 

    Paralogs
    for PRKCA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKCA gene
    PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PKN12  PRKCD2  PRKCZ2  
    PKN32  PRKCG2  PKN22  
    18/54 SIMAP similar genes for PRKCA using alignment to 6 protein entries:     KPCA_HUMAN (see all proteins) (see all similar genes):
    PRKCB    PRKCG    PRKD1    PRKCH    RPH3A    AKT1
    RPS6KA2    RPS6KA3    DOC2A    KIN27    PRKCE    PRKACB
    PRKCI    AKT3    MARK4    PRKACG    PRKACA    SGK2

    PRKCA for paralogs           About GeneDecksing



    Genomic Variants
    for PRKCA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9395 NCBI SNPs in PRKCA are shown (see all 9395)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs360454171,2
    		C--60013668(+) TTGTA-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs340641091,2
    		C--60120317(+) AAAAA-/AGATTT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1456553511,2
    		C--60127320(+) TTGAGA/GGGGGA 1 -- int10--------
    rs778858971,2
    		C,F,--64296951(+) CATTCC/AACTAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1494565031,2
    		--64297041(+) ATTTCC/TCCAAC 1 -- us2k10--------
    rs1446259081,2
    		--64297073(+) TTTGCC/TTCTTC 1 -- us2k10--------
    rs1832125311,2
    		--64297224(+) CTGACA/GGCCAG 1 -- us2k10--------
    rs99095751,2
    		C,--64297241(+) GAGCTT/CCCATT 1 -- us2k12Minor allele frequency- C:0.06WA 120
    rs1422741871,2
    		--64297374(+) TTTTTC/TCAACA 1 -- us2k10--------
    rs37644021,2
    		C,F,H,--64297453(-) GATTCA/GCGAAA 1 -- us2k114Minor allele frequency- G:0.12EA NS NA 2648

    HapMap Linkage Disequilibrium report for PRKCA (64298754 - 64548754 bp, first 250kb of PRKCA)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for PRKCA
         2 CNVs: 35484 39207
         4 Indels: 67245 11891 49915 45572

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKCA
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    Disorders / Diseases
    for PRKCA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKCA for disorders           About GeneDecksing

    OMIM gene information: 176960    OMIM disorders: --

    20/130 diseases for PRKCA (see all 130):    About MalaCards
    pituitary tumor, invasive    non-small cell lung carcinoma    bacterial vaginosis    non-hodgkin lymphoma
    soft tissue sarcoma    pituitary tumor    hypertrophic cardiomyopathy    familial hypertrophic cardiomyopathy
    myofibrillar myopathy    myxoid chondrosarcoma    spina bifida    membranous glomerulonephritis
    pituitary adenoma    b-cell lymphomas    insulin resistance    oral squamous cell carcinoma
    malignant glioma    muscle hypertrophy    carcinoma    cystic fibrosis

    10/95 Novoseek disease relationships for PRKCA gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 42.3 35 7595754 (5), 9676858 (4), 10848585 (2), 11170840 (2) (see all 18)
    erythroleukemia 37.2 3 9925750 (2), 9685375 (1)
    tumors 32.8 108 16008942 (5), 15930268 (3), 15922420 (3), 14966210 (2) (see all 62)
    breast carcinoma 28.2 14 14966210 (2), 9146728 (2), 9284950 (2), 9563854 (1) (see all 9)
    melanoma 24.5 57 12839565 (10), 15057036 (5), 20216103 (5), 11894137 (3) (see all 14)
    colon cancer 23.5 19 9547673 (4), 20141613 (4), 19232344 (2), 19417139 (1) (see all 8)
    breast cancer 23.4 64 16407820 (4), 20398285 (3), 11371124 (3), 11525643 (3) (see all 29)
    glioblastoma 23 15 7838340 (4), 7931620 (1), 10628339 (1), 15701280 (1) (see all 6)
    cancer 21.6 36 16407820 (3), 15531915 (2), 20153162 (2), 15180529 (2) (see all 23)
    prostate cancer 18.6 29 12497586 (3), 19029835 (2), 16979586 (2), 10825394 (1) (see all 19)

    Genetic Association Database (GAD): PRKCA
    Human Genome Epidemiology (HuGE) Navigator: PRKCA (18 documents)

    Export disorders for PRKCA gene to outside databases

    Publications
    for PRKCA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKCA gene, integrated from 9 sources (see all 1433):
    (articles sorted by number of sources associating them with PRKCA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. (PubMed id 18056764)1, 2, 9 Xu H....Li H. (2008)
    2. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. (PubMed id 15155525)1, 4, 9 Barton A....Worthington J. (2004)
    3. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. (PubMed id 10848585)1, 2, 9 Besson A. and Yong V.W. (2000)
    4. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. (PubMed id 9738012)1, 2, 9 Ruvolo P.P....May W.S. (1998)
    5. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. (PubMed id 15504744)1, 2, 9 Makagiansar I.T.... Stallcup W.B. (2004)
    6. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. (PubMed id 11909826)1, 2, 9 Wang A....Ware J.A. (2002)
    7. Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. (PubMed id 21576361)1, 2 Dobrikov M.... Gromeier M. (2011)
    8. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. (PubMed id 17893151)1, 2 Chen D.... Newton A.C. (2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for PRKCA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKCA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5578 HGNC: 9393 AceView: PRKCA Ensembl:ENSG00000154229 euGenes: HUgn5578
    ECgene: PRKCA Kegg: 5578 H-InvDB: PRKCA

    Other Databases showing PRKCA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKCA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKCA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKCA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PRKCA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKCA gene:
    Search GeneIP for patents involving PRKCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRKCA gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKCA
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