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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKAR2B Gene

protein-coding   GIFtS: 67
GCID: GC07P106685

protein kinase, cAMP-dependent, regulatory, type II, beta


(Previous symbol: PRKAR2)
 Explore 25 diseases affiliated with
PRKAR2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKAR2B    

Aliases
for PRKAR2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type II, Beta1 2     WUGSC:H_RG363E19.22
PRKAR21 2     CAMP-Dependent Protein Kinase Type II-Beta Regulatory Chain2
H_RG363E19.22     CAMP-Dependent Protein Kinase Type II-Beta Regulatory Subunit2
RII-BETA2     

External Ids:    HGNC: 93921   Entrez Gene: 55772   Ensembl: ENSG000000052497   OMIM: 1769125   UniProtKB: P313233   

Export aliases for PRKAR2B gene to outside databases

Previous GC identifers: GC07P105169 GC07P106231 GC07P106245 GC07P106279 GC07P106472 GC07P101045


Summaries
for PRKAR2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKAR2B:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the
cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The
inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the
dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric
catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.
The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the
activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of
the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this
subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this
subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

summary for PRKAR2B:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR2B


Genomic Views
for PRKAR2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKAR2B gene promoter:
         MEF-2A   AREB6   CREB   C/EBPbeta   deltaCREB   aMEF-2   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PRKAR2B promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKAR2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAR2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.3

PRKAR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR2B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106685:  view genomic region     (about GC identifiers)

Start:
 106,685,094 bp from pter      End:
 106,802,256 bp from pter
Size:
 117,163 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,046,282-106,163,333     

Proteins
for PRKAR2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type II-beta regulatory subunit  
Size: 418 amino acids; 46302 Da
Subunit: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by
cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the
phosphorylated form of PJA2
Subcellular location: Cytoplasm. Cell membrane. Note=Co-localizes with PJA2 in the cytoplasm and at the cell membrane
Secondary accessions: A4D0R9

Explore the universe of human proteins at neXtProt for PRKAR2B: NX_P31323

Post-translational modifications:

  • Phosphorylated by the activated catalytic chain1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31323

    • PRKAR2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002727.2  
    ENSEMBL proteins: 
     ENSP00000265717   ENSP00000440531  
    Reactome Protein details: P31323
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PRKAR2B Protein
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    OriGene Purified Protein: PRKAR2B
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    Novus Biologicals PRKAR2B Protein
    Novus Biologicals PRKAR2B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000267cell fraction ----
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005737cytoplasm IDA--


    PRKAR2B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PRKAR2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKAR2B for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P31323

    ProtoNet protein and cluster: P31323

    3 Blocks protein families:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    Function
    for PRKAR2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
    regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

         Genatlas biochemistry entry for PRKAR2B:
    protein kinase,cAMP-dependent,type II,beta subunit,regulatory polypeptide

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKAR2B
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAR2B (see all 35):
    hsa-miR-194* hsa-miR-429 hsa-miR-25 hsa-miR-218 hsa-miR-34b hsa-miR-200b hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: PRKAR2B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAR2B (see all 7)
    OriGene shRNA RFP: PRKAR2B
    OriGene siRNA: PRKAR2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAR2B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKAR2B

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR2B (see all 3)
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    GenScript: all cDNA clones in your preferred vector: PRKAR2B (NM_002736)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for PRKAR2B

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR2B

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008603cAMP-dependent protein kinase regulator activity IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0030552cAMP binding IEA--
    GO:0031625ubiquitin protein ligase binding IDA--


    PRKAR2B for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PRKAR2B:
     Decreased telomerase activity  Paclitaxel antagonistic effect  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for PRKAR2B: Prkar2btm1Gsm Prkar2btm2Gsm
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prkar2b):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  pigmentation 

    PRKAR2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRKAR2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/65 super-pathways (see all 65) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PKA activation in glucagon signalling
    8/12 pathways (see all 12)
    		PKA activation in glucagon signalling1.00
    		Neurophysiological process_PGE2-induced pain processing0.44
    		PKA activation0.94
    		Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.37
    		PKA-mediated phosphorylation of CREB0.89
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    		Regulation of CFTR gating (normal and CF)0.76
    		Development Role of Activin A in cell differentiation and proliferation0.33
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/26 EMD Millipore Pathways for PRKAR2B (see all 26)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Transcription PPAR Pathway

    5/53 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAR2B (see all 53)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    5/32 GeneGo (Thomson Reuters) Pathways for PRKAR2B (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PRKAR2B 
        Calcium Regulation in the Cardiac Cell
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Myometrial Relaxation and Contraction Pathways
    miRs in Muscle Cell Differentiation

    5/50        Reactome Pathways for PRKAR2B (see all 50)
        PKA activation
    Recruitment of mitotic centrosome proteins and complexes
    Signaling by EGFR in Cancer
    Downstream signal transduction
    DARPP-32 events


    2         Kegg Pathways  (Kegg details for PRKAR2B):
        Apoptosis
    Insulin signaling pathway


    PRKAR2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKAR2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for PRKAR2B (P313232, 3 ENSP000002657174) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP10O435723, ENSP000002257374I2D: score=2 STRING: ENSP00000225737
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    MAATS1Q7Z4T93, ENSP000002733904I2D: score=1 STRING: ENSP00000273390
    AKAP5P245883, ENSP000003156154I2D: score=2 STRING: ENSP00000315615
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006631fatty acid metabolic process IEA--
    GO:0006833water transport TAS--


    PRKAR2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKAR2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKAR2B for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKAR2B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PRKAR2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog[76939-46-3]
    cAMPS-Rp, triethylammonium salt cAMP antagonist[73208-40-9]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]
    Dibutyryl-cAMP, sodium salt Cell-permeable cAMP analog[16980-89-5]

    1 HMDB Compound for PRKAR2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 DrugBank Compound for PRKAR2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4target--17139284 17016423 10592235

    2 Novoseek chemical compound relationships for PRKAR2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 38.6 2 11087674 (1)
    forskolin 32.6 3 1976635 (1), 18544528 (1), 1692323 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKAR2B / KAP3 

    Transcripts
    for PRKAR2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKAR2B gene: 
    NM_002736.2  

    Unigene Cluster for PRKAR2B:

    Protein kinase, cAMP-dependent, regulatory, type II, beta
    Hs.433068  [show with all ESTs]
    Unigene Representative Sequence: BC075800
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265717(uc003vdx.3) ENST00000393613 ENST00000488792 ENST00000543645


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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAR2B (see all 35):
    hsa-miR-194* hsa-miR-429 hsa-miR-25 hsa-miR-218 hsa-miR-34b hsa-miR-200b hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: PRKAR2B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAR2B (see all 7)
    OriGene shRNA RFP: PRKAR2B
    OriGene siRNA: PRKAR2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAR2B
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAR2B
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    Additional cDNA sequence: 

    AK128639.1 AK291441.1 BC014355.1 BC075800.1 M31158.1 

    8 DOTS entries:

    DT.446604  DT.100685913  DT.75102423  DT.100773153  DT.101956630  DT.92429367  DT.95260328  DT.95260326 

    24/150 AceView cDNA sequences (see all 150):

    BM721983 AI473509 BM473595 AI733577 BU182360 CA405423 AL045146 CD673818 
    AI792179 BX279902 AI081026 BF114852 F06849 CR604245 AU119992 BU173475 
    BX379950 AV707068 CD676674 NM_002736 AA339672 BC075800 CD653799 C18185 

    GeneLoc Exon Structure


    Expression
    for PRKAR2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKAR2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAACAGCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRKAR2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType3b Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    TestisTestis InterstitiumTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    White adipocyte-like cells (Differentiation of ...)Adipose

    See PRKAR2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKAR2B

    SOURCE GeneReport for Unigene cluster: Hs.433068

    UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression
    varies among tissues and is in some cases constitutive and in others inducible

        SABiosciences Expression via Pathway-Focused PCR Array including PRKAR2B: 
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    Orthologs
    for PRKAR2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR2B gene from 6/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRKAR2B1 protein kinase, cAMP-dependent, regulatory, type II, more 84.54(n)
    91.78(a)    		   769420  XM_001232696.2  XP_001232697.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PRKAR2B6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(97219141-97253504)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.237342 Xenopus laevis transcribed sequence with moderate similarity more 77.85(n)    AW643067.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01046114.16
    CABZ01071153.16
    		 --
    		 74(a)
    14(a)
    		 1 ↔ 1
    possible ortholog
    		 25(3531545-3542010)
    8(53175955-53208163)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pka-R26
    		 cAMP-dependent protein kinase R2
    		 47(a)
    		 1 → many
    		 2R(5881395-5913547)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes BCY11 Bcy1p 48.29(n)
    37.03(a)    		   854778   NP_012231.1 


    ENSEMBL Gene Tree for PRKAR2B (if available)
    TreeFam Gene Tree for PRKAR2B (if available) 

    Paralogs
    for PRKAR2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKAR2B gene
    PRKAR1B2  PRKAR2A2  PRKAR1A2  
    7 SIMAP similar genes for PRKAR2B using alignment to 4 protein entries:     KAP3_HUMAN (see all proteins):
    PRKAR2A    RET/PTC2    PRKAR1A    DKFZp779L0468    PRKAR1B    PRKG1
    WUGSC

    PRKAR2B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRKAR2B
    PGOHUM00000242306 PGOHUM00000242308


    Genomic Variants
    for PRKAR2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1849 NCBI SNPs in PRKAR2B are shown (see all 1849)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1916391131,2
    		--106683504(+) TAATGC/GTTACA 1 -- us2k10--------
    rs1837928801,2
    		--106683515(+) CGGTAC/GAGAGT 1 -- us2k10--------
    rs774942741,2
    		F,--106683543(+) CCAACC/TGGTGA 1 -- us2k12Minor allele frequency- T:0.11WA EA 238
    rs117646051,2
    		C,H--106683772(+) TAGTAG/AAGATG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1889743471,2
    		--106683790(+) ACCATA/GTTGGC 1 -- us2k10--------
    rs7222361,2
    		C,F,A,--106684247(+) AATAGA/CATTTA 1 -- us2k114Minor allele frequency- C:0.42NA PA WA CSA EA 704
    rs1409458341,2
    		--106684276(+) TCTCTA/GCTTCA 1 -- us2k10--------
    rs787158181,2
    		C,--106684638(+) AAAGAC/GGTCAC 1 -- us2k13Minor allele frequency- G:0.06NA EA 242
    rs1824220191,2
    		--106684686(+) AGTACC/TACCAT 1 -- us2k10--------
    rs1451006591,2
    		--106684792(+) AAGACA/CAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKAR2B (106685094 - 106802256 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PRKAR2B
         1 CNV: 7594

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    Disorders / Diseases
    for PRKAR2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKAR2B for disorders           About GeneDecksing

    OMIM gene information: 176912    OMIM disorders: --

    20/25 diseases for PRKAR2B (see all 25):    About MalaCards
    carney complex    bipolar affective disorder    systemic lupus erythematosus    adrenocortical hyperplasia
    lupus erythematosus    acute lymphoblastic leukemia    lymphoblastic leukemia    adrenocortical tumor
    colon carcinoma    neurologic diseases    leukemia    alzheimer's disease
    osteoarthritis    ovarian cancer    prostate carcinoma    carcinoma
    cerebritis    neuroblastoma    prostatitis    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for PRKAR2B:
    Carney complex

    5 Novoseek disease relationships for PRKAR2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 44.8 1 1689049 (1)
    colon carcinoma 28.8 2 8654392 (1)
    leukemia 0 1 1689049 (1)
    tumors 0 3 16394127 (2), 10999726 (1)
    cancer 0 5 2000408 (1), 1689049 (1), 10999726 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRKAR2B (5 documents)

    Export disorders for PRKAR2B gene to outside databases

    Publications
    for PRKAR2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKAR2B gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with PRKAR2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PubMed id 1358799)1, 3, 9 Solberg R....de la Chapelle A. (1992)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis. (PubMed id 2851102)1, 2 Levy F.O....Jahnsen T. (1988)
    4. An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. (PubMed id 1689049)1, 9 Tortora G....Cho-Chung Y.S. (1990)
    5. Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. (PubMed id 18544528)1, 9 Ji Z....Cheng X. (2008)
    6. Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts. (PubMed id 1582408)1, 9 Rios R.M....Keryer G. (1992)
    7. Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton. (PubMed id 7829531)1, 9 Li Y. and Rubin C.S. (1995)
    8. Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. (PubMed id 8509414)1, 9 Glantz S.B....Rubin C.S. (1993)
    9. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1 McCormack M....Cavalleri G.L. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for PRKAR2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKAR2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5577 HGNC: 9392 AceView: PRKAR2B Ensembl:ENSG00000005249 euGenes: HUgn5577
    ECgene: PRKAR2B Kegg: 5577 H-InvDB: PRKAR2B

    Other Databases showing PRKAR2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKAR2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKAR2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAR2B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PRKAR2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKAR2B gene:
    Search GeneIP for patents involving PRKAR2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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