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PRKAR2B Gene

protein-coding   GIFtS: 71
GCID: GC07P106685

Protein Kinase, CAMP-Dependent, Regulatory, Type II, Beta


(Previous symbol: PRKAR2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type II, Beta1 2     WUGSC:H_RG363E19.22
PRKAR21 2     CAMP-Dependent Protein Kinase Type II-Beta Regulatory Chain2
H_RG363E19.22     CAMP-Dependent Protein Kinase Type II-Beta Regulatory Subunit2
RII-BETA2     

External Ids:    HGNC: 93921   Entrez Gene: 55772   Ensembl: ENSG000000052497   OMIM: 1769125   UniProtKB: P313233   

Export aliases for PRKAR2B gene to outside databases

Previous GC identifers: GC07P105169 GC07P106231 GC07P106245 GC07P106279 GC07P106472 GC07P101045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKAR2B Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can
be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress
the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells.
Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and
adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior
induced by haloperidol. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKAR2B Gene:
PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta) is a protein-coding gene. Diseases associated with PRKAR2B include carney complex, and neurologic diseases. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity and protein domain specific binding. An important paralog of this gene is PRKAR1B.

UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

summary for PRKAR2B Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAR2B gene promoter:
         MEF-2A   AREB6   CREB   C/EBPbeta   deltaCREB   aMEF-2   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PRKAR2B promoter sequence
   Search Chromatin IP Primers for PRKAR2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAR2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.3

PRKAR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR2B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P106685:  view genomic region     (about GC identifiers)

Start:
106,685,094 bp from pter      End:
106,802,256 bp from pter
Size:
117,163 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 106,046,282-106,163,333     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type II-beta regulatory subunit  
Size: 418 amino acids; 46302 Da
Subunit: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation
by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts
with the phosphorylated form of PJA2
Secondary accessions: A4D0R9

Explore the universe of human proteins at neXtProt for PRKAR2B: NX_P31323

Explore proteomics data for PRKAR2B at MOPED

Post-translational modifications: 

  • Phosphorylated by the activated catalytic chain1
  • Ubiquitination2 at Lys359
  • Modification sites at PhosphoSitePlus

  • See PRKAR2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002727.2  
    ENSEMBL proteins: 
     ENSP00000265717  
    Reactome Protein details: P31323

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, regulatory, type II, beta subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P31323

    ProtoNet protein and cluster: P31323

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    PRKAR2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAP3_HUMAN, P31323
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
    regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

         Genatlas biochemistry entry for PRKAR2B:
    protein kinase,cAMP-dependent,type II,beta subunit,regulatory polypeptide

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity IDA--
    GO:0008603cAMP-dependent protein kinase regulator activity IDA--
    GO:0019904protein domain specific binding ----
    GO:0030552cAMP binding IEA--
    GO:0031625ubiquitin protein ligase binding IDA--
         
    PRKAR2B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRKAR2B:
     Decreased telomerase activity  Paclitaxel antagonistic effect  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkar2b):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system  pigmentation 

    PRKAR2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKAR2B: Prkar2btm1Gsm Prkar2btm3Gsm Prkar2btm2Gsm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKAR2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKAR2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAR2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKAR2B

    miRNA
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    miRTarBase miRNAs that target PRKAR2B:
    hsa-mir-590-3p (MIRT016228)

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    Selected qRT-PCR Assays for microRNAs that regulate PRKAR2B (see all 35):
    hsa-miR-194* hsa-miR-429 hsa-miR-25 hsa-miR-218 hsa-miR-34b hsa-miR-200b hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidPRKAR2B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAP3_HUMAN, P31323: Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell
    membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    mitochondrion2
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005743mitochondrial inner membrane ----
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    PRKAR2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKAR2B About   (see all 61)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    4G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    5Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAR2B (see all 53)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKAR2B (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PRKAR2B
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    miRs in Muscle Cell Differentiation


    Selected Reactome Pathways for PRKAR2B (see all 10)
        PKA activation
    Recruitment of mitotic centrosome proteins and complexes
    Regulation of PLK1 Activity at G2/M Transition
    PKA activation in glucagon signalling
    DARPP-32 events


    2 Kegg Pathways  (Kegg details for PRKAR2B):
        Apoptosis
    Insulin signaling pathway


    PRKAR2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKAR2B: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAR2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAR2B (P313232, 3 ENSP000002657174) via UniProtKB, MINT, STRING, and/or I2D (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP10O435723, ENSP000002257374I2D: score=2 STRING: ENSP00000225737
    AKAP4Q5JQC93, ENSP000003513274I2D: score=1 STRING: ENSP00000351327
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    RYR2Q927363, ENSP000003555334I2D: score=1 STRING: ENSP00000355533
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001932regulation of protein phosphorylation ----
    GO:0006112energy reserve metabolic process TAS--
    GO:0006631fatty acid metabolic process IEA--

    PRKAR2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKAR2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    1 HMDB Compound for PRKAR2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 DrugBank Compound for PRKAR2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4target--17139284 17016423 10592235

    2 Novoseek inferred chemical compound relationships for PRKAR2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 38.6 2 11087674 (1)
    forskolin 32.6 3 1976635 (1), 18544528 (1), 1692323 (1)



    PRKAR2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKAR2B gene: 
    NM_002736.2  

    Unigene Cluster for PRKAR2B:

    Protein kinase, cAMP-dependent, regulatory, type II, beta
    Hs.433068  [show with all ESTs]
    Unigene Representative Sequence: BC075800
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265717(uc003vdx.3) ENST00000393613 ENST00000488792
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-194* hsa-miR-429 hsa-miR-25 hsa-miR-218 hsa-miR-34b hsa-miR-200b hsa-miR-3148 hsa-miR-92b
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      QuantiFast Probe-based Assays in human, mouse, rat PRKAR2B

    Additional mRNA sequence: 

    AK128639.1 AK291441.1 BC014355.1 BC075800.1 M31158.1 

    8 DOTS entries:

    DT.446604  DT.100685913  DT.75102423  DT.100773153  DT.101956630  DT.92429367  DT.95260328  DT.95260326 

    Selected AceView cDNA sequences (see all 150):

    AV707068 NM_002736 CD673818 CA405423 AL045146 BU182360 AA339672 BM721983 
    BF114852 BX379950 F06849 CR604245 AU119992 BU173475 CD676674 AI792179 
    BX279902 BC075800 AI473509 AI733577 BM473595 AI081026 BX444918 CA407423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKAR2B expression in normal human tissues (normalized intensities)      PRKAR2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACAGCAAA
    PRKAR2B Expression
    About this image


    PRKAR2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    PRKAR2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAR2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433068

    UniProtKB/Swiss-Prot: KAP3_HUMAN, P31323
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their
    expression varies among tissues and is in some cases constitutive and in others inducible

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKAR2B: 
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkar2b1 , 5 protein kinase, cAMP dependent regulatory, type II more1, 5 91.11(n)1
    97.36(a)1
      12 (13.74 cM)5
    190881  NM_011158.31  NP_035288.21 
     319584765 
    chicken
    (Gallus gallus)
    Aves PRKAR2B1 protein kinase, cAMP-dependent, regulatory, type II, more 84.49(n)
    92.09(a)
      769420  XM_001232696.3  XP_001232697.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAR2B6
    protein kinase, cAMP-dependent, regulatory, type I...
    79(a)
    1 ↔ 1
    5(97161282-97253810)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237342 Xenopus laevis transcribed sequence with moderate similarity more 77.85(n)    AW643067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003313871 cAMP-dependent protein kinase type II-beta regulatory more 68.03(n)
    77.04(a)
      100331387  XM_002666769.3  XP_002666815.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-R26
    cAMP-dependent protein kinase R2
    47(a)
    1 → many
    2R(5881395-5913547)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCY16
    Regulatory subunit of the cyclic AMP-dependent pro...
    30(a)
    1 → many
    IX(290419-291669) YIL033C


    ENSEMBL Gene Tree for PRKAR2B (if available)
    TreeFam Gene Tree for PRKAR2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKAR2B gene
    PRKAR1B2  PRKAR2A2  PRKAR1A2  
    7 SIMAP similar genes for PRKAR2B using alignment to 4 protein entries:     KAP3_HUMAN (see all proteins):
    PRKAR2A    RET/PTC2    PRKAR1A    DKFZp779L0468    PRKAR1B    PRKG1
    WUGSC

    PRKAR2B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRKAR2B
    PGOHUM00000242306 PGOHUM00000242308


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKAR2B (see all 2141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916391131,2
    --106683504(+) TAATGC/GTTACA 1 -- us2k10--------
    rs1837928801,2
    --106683515(+) CGGTAC/GAGAGT 1 -- us2k10--------
    rs774942741,2
    C,F--106683543(+) CCAACC/TGGTGA 1 -- us2k12Minor allele frequency- T:0.11WA EA 238
    rs117646051,2
    C,H--106683772(+) TAGTAG/AAGATG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1889743471,2
    --106683790(+) ACCATA/GTTGGC 1 -- us2k10--------
    rs7222361,2
    C,F,A--106684247(+) AATAGA/CATTTA 1 -- us2k114Minor allele frequency- C:0.42NA PA WA CSA EA 704
    rs1409458341,2
    --106684276(+) TCTCTA/GCTTCA 1 -- us2k10--------
    rs787158181,2
    C--106684638(+) AAAGAC/GGTCAC 1 -- us2k13Minor allele frequency- G:0.06NA EA 242
    rs1824220191,2
    --106684686(+) AGTACC/TACCAT 1 -- us2k10--------
    rs1451006591,2
    --106684792(+) AAGACA/CAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKAR2B (106685094 - 106802256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRKAR2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675749CNV Deletion23128226
    esv274079CNV Insertion20981092
    esv32754CNV Loss17666407
    nsv831087CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176912    OMIM disorders: --

    Selected diseases for PRKAR2B (see all 22):    About MalaCards
    carney complex    neurologic diseases    brain cancer    osteoarthritis
    lymphoblastic leukemia    cystic fibrosis    hiv-1    systemic lupus erythematosus
    lupus erythematosus    neuroblastoma    leukemia    cerebritis
    colorectal cancer    ovarian cancer    obesity    alzheimer's disease
    thyroiditis    endotheliitis    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PRKAR2B:
    Carney complex

    PRKAR2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for PRKAR2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 44.8 1 1689049 (1)
    colon carcinoma 28.8 2 8654392 (1)
    leukemia 0 1 1689049 (1)
    tumors 0 3 16394127 (2), 10999726 (1)
    cancer 0 5 2000408 (1), 1689049 (1), 10999726 (1)

    Genetic Association Database (GAD): PRKAR2B
    Human Genome Epidemiology (HuGE) Navigator: PRKAR2B (5 documents)

    Export disorders for PRKAR2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKAR2B gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with PRKAR2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PubMed id 1358799)1, 3, 9 Solberg R....de la Chapelle A. (Genomics 1992)
    2. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. (PubMed id 21068099)1, 4 Evangelou E....Spector T.D. (Ann. Rheum. Dis. 2011)
    3. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PubMed id 20195266)1, 4 Adkins D.E....van den Oord E.J. (Mol. Psychiatry 2011)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis. (PubMed id 2851102)1, 2 Levy F.O....Jahnsen T. (Mol. Endocrinol. 1988)
    6. An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. (PubMed id 1689049)1, 9 Tortora G....Cho-Chung Y.S. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    7. Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. (PubMed id 18544528)1, 9 Ji Z....Cheng X. (J. Biol. Chem. 2008)
    8. Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts. (PubMed id 1582408)1, 9 Rios R.M....Keryer G. (EMBO J. 1992)
    9. Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton. (PubMed id 7829531)1, 9 Li Y. and Rubin C.S. (J. Biol. Chem. 1995)
    10. Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. (PubMed id 8509414)1, 9 Glantz S.B....Rubin C.S. (J. Biol. Chem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5577 HGNC: 9392 AceView: PRKAR2B Ensembl:ENSG00000005249 euGenes: HUgn5577
    ECgene: PRKAR2B Kegg: 5577 H-InvDB: PRKAR2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKAR2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAR2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKAR2B gene:
    Search GeneIP for patents involving PRKAR2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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