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Aliases for PRKAR2A Gene

Aliases for PRKAR2A Gene

  • Protein Kinase, CAMP-Dependent, Regulatory, Type II, Alpha 2 3
  • PRKAR2 3 4
  • PKR2 3 4
  • CAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit 3
  • CAMP-Dependent Protein Kinase Regulatory Subunit RII Alpha 3
  • Protein Kinase A, RII-Alpha Subunit 3

External Ids for PRKAR2A Gene

Previous Symbols for PRKAR2A Gene

  • PRKAR2

Summaries for PRKAR2A Gene

Entrez Gene Summary for PRKAR2A Gene

  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAR2A Gene

PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, Alpha) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include ubiquitin protein ligase binding and cAMP binding. An important paralog of this gene is PRKAR2B.

UniProtKB/Swiss-Prot for PRKAR2A Gene

  • Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

Tocris Summary for PRKAR2A Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAR2A Gene

Genomics for PRKAR2A Gene

Genomic Location for PRKAR2A Gene

Start:
48,744,597 bp from pter
End:
48,847,846 bp from pter
Size:
103,250 bases
Orientation:
Minus strand

Genomic View for PRKAR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAR2A Gene

Regulatory Elements for PRKAR2A Gene

Proteins for PRKAR2A Gene

  • Protein details for PRKAR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13861-KAP2_HUMAN
    Recommended name:
    cAMP-dependent protein kinase type II-alpha regulatory subunit
    Protein Accession:
    P13861
    Secondary Accessions:
    • Q16823
    • Q9BUB1

    Protein attributes for PRKAR2A Gene

    Size:
    404 amino acids
    Molecular mass:
    45518 Da
    Quaternary structure:
    • The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRKAR2A Gene

    Alternative splice isoforms for PRKAR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAR2A Gene

Proteomics data for PRKAR2A Gene at MOPED

Post-translational modifications for PRKAR2A Gene

Other Protein References for PRKAR2A Gene

No data available for DME Specific Peptides for PRKAR2A Gene

Domains for PRKAR2A Gene

UniProtKB/Swiss-Prot:

KAP2_HUMAN
Domain:
  • Contains 2 cyclic nucleotide-binding domains.:
    • P13861
Family:
  • Belongs to the cAMP-dependent kinase regulatory chain family.:
    • P13861
genes like me logo Genes that share domains with PRKAR2A: view

Function for PRKAR2A Gene

Molecular function for PRKAR2A Gene

GENATLAS Biochemistry: protein kinase,cAMP dependent,regulatory type II,alpha subunit,ubiquitously expressed,interacting with A kinase anchoring proteins,necessary for cAMP dependent modulation of ion channels
UniProtKB/Swiss-Prot Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

Gene Ontology (GO) - Molecular Function for PRKAR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004862 cAMP-dependent protein kinase inhibitor activity IDA 21812984
GO:0005515 protein binding IPI 11278869
GO:0008603 cAMP-dependent protein kinase regulator activity NAS 9003463
GO:0016301 kinase activity --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with PRKAR2A: view

Phenotypes for PRKAR2A Gene

MGI mutant phenotypes for PRKAR2A:
inferred from 1 alleles
GenomeRNAi human phenotypes for PRKAR2A:
genes like me logo Genes that share phenotypes with PRKAR2A: view

Animal Models for PRKAR2A Gene

MGI Knock Outs for PRKAR2A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKAR2A Gene

Localization for PRKAR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAR2A Gene

Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAR2A Gene COMPARTMENTS Subcellular localization image for PRKAR2A gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRKAR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21423175
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 21423175
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PRKAR2A: view

Pathways for PRKAR2A Gene

SuperPathways for PRKAR2A Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 G-Beta Gamma Signaling
4 GPCR Pathway
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with PRKAR2A: view

Gene Ontology (GO) - Biological Process for PRKAR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation --
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with PRKAR2A: view

Compounds for PRKAR2A Gene

(5) Tocris Compounds for PRKAR2A Gene

Compound Action Cas Number
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog [71774-13-5]
H 89 dihydrochloride Protein kinase A inhibitor [127243-85-0]
KT 5720 Selective protein kinase A inhibitor [108068-98-0]
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor [121932-06-7]
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor [201422-03-9]

(1) HMDB Compounds for PRKAR2A Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with PRKAR2A: view

Transcripts for PRKAR2A Gene

Unigene Clusters for PRKAR2A Gene

Protein kinase, cAMP-dependent, regulatory, type II, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
SP1:
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for PRKAR2A Gene

GeneLoc Exon Structure for
PRKAR2A
ECgene alternative splicing isoforms for
PRKAR2A

Expression for PRKAR2A Gene

mRNA expression in normal human tissues for PRKAR2A Gene

mRNA differential expression in normal tissues according to GTEx for PRKAR2A Gene

This gene is overexpressed in Muscle - Skeletal (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAR2A Gene

SOURCE GeneReport for Unigene cluster for PRKAR2A Gene Hs.631923

mRNA Expression by UniProt/SwissProt for PRKAR2A Gene

P13861-KAP2_HUMAN
Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
genes like me logo Genes that share expressions with PRKAR2A: view

Orthologs for PRKAR2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKAR2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAR2A 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAR2A 36
  • 90.27 (n)
  • 90.27 (a)
PRKAR2A 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAR2A 36
  • 91.52 (n)
  • 92.02 (a)
PRKAR2A 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkar2a 36
  • 87.07 (n)
  • 87.15 (a)
Prkar2a 16
Prkar2a 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAR2A 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAR2A 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkar2a 36
  • 86.36 (n)
  • 87.37 (a)
chicken
(Gallus gallus)
Aves LOC100858827 36
  • 76.63 (n)
  • 79.12 (a)
PRKAR2A 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAR2A 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkar2a 36
  • 71.55 (n)
  • 74.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3297 36
zebrafish
(Danio rerio)
Actinopterygii prkar2aa 36
  • 70.58 (n)
  • 72.96 (a)
prkar2aa 37
  • 73 (a)
OneToMany
prkar2ab 37
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004940 36
  • 58.49 (n)
  • 53.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pka-R2 36
  • 56.45 (n)
  • 52.92 (a)
Pka-R2 37
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL099C 36
  • 48.98 (n)
  • 40.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCY1 36
  • 51.38 (n)
  • 43.68 (a)
BCY1 37
  • 31 (a)
OneToMany
BCY1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04181g 36
  • 51.64 (n)
  • 41.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01166 36
  • 50.95 (n)
  • 45.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cgs1 36
  • 49.61 (n)
  • 40.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8307 37
  • 50 (a)
OneToMany
Species with no ortholog for PRKAR2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRKAR2A Gene

ENSEMBL:
Gene Tree for PRKAR2A (if available)
TreeFam:
Gene Tree for PRKAR2A (if available)

Paralogs for PRKAR2A Gene

Paralogs for PRKAR2A Gene

Selected SIMAP similar genes for PRKAR2A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PRKAR2A: view

Variants for PRKAR2A Gene

Sequence variations from dbSNP and Humsavar for PRKAR2A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14018 -- 48,746,837(-) ATGTC(C/T)TTCAT utr-variant-3-prime, nc-transcript-variant
rs15422 -- 48,747,192(+) CATTG(C/T)AGTGA utr-variant-3-prime, nc-transcript-variant
rs1352421 -- 48,752,371(+) GGGCA(G/T)GTCCA intron-variant
rs1387006 -- 48,752,265(+) CCTTA(G/T)GGCAG reference, missense, intron-variant
rs2230509 -- 48,765,032(-) GATCT(A/G)TAAGG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAR2A Gene

Variant ID Type Subtype PubMed ID
nsv508918 CNV Insertion 20534489
esv1169569 CNV Deletion 17803354

Relevant External Links for PRKAR2A Gene

HapMap Linkage Disequilibrium report
PRKAR2A

Disorders for PRKAR2A Gene

Relevant External Links for PRKAR2A

Genetic Association Database (GAD)
PRKAR2A
Human Genome Epidemiology (HuGE) Navigator
PRKAR2A
genes like me logo Genes that share disorders with PRKAR2A: view

No data available for UniProtKB/Swiss-Prot for PRKAR2A Gene

Publications for PRKAR2A Gene

  1. Human testis cDNA for the regulatory subunit RII alpha of cAMP- dependent protein kinase encodes an alternate amino-terminal region. (PMID: 2540040) Oyen O. … Jahnsen T. (FEBS Lett. 1989) 3 4
  2. Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase. (PMID: 9003463) Foss K.B. … Tasken K. (Biochim. Biophys. Acta 1997) 3 4
  3. Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2. (PMID: 9676433) TaskAcn K. … Jahnsen T. (Genomics 1998) 2 3
  4. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PMID: 11823486) Schillace R.V. … Carr D.W. (J. Immunol. 2002) 3 4
  5. Phosphoproteomic analysis of the human pituitary. (PMID: 16807684) Beranova-Giorgianni S. … Giorgianni F. (Pituitary 2006) 3 4

Products for PRKAR2A Gene

Sources for PRKAR2A Gene

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