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PRKAR2A Gene

protein-coding   GIFtS: 67
GCID: GC03M048782

Protein Kinase, CAMP-Dependent, Regulatory, Type II, Alpha


(Previous symbol: PRKAR2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type II, Alpha1 2
PRKAR21 2 3
PKR22 3
CAMP-Dependent Protein Kinase Regulatory Subunit RII Alpha2
CAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit2
Protein Kinase A, RII-Alpha Subunit2

External Ids:    HGNC: 93911   Entrez Gene: 55762   Ensembl: ENSG000001143027   OMIM: 1769105   UniProtKB: P138613   

Export aliases for PRKAR2A gene to outside databases

Previous GC identifers: GC03M048574 GC03M048067 GC03M048746 GC03M048747 GC03M048762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKAR2A Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can
be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins
and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to
regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
(provided by RefSeq, Jul 2008)

GeneCards Summary for PRKAR2A Gene:
PRKAR2A (protein kinase, cAMP-dependent, regulatory, type II, alpha) is a protein-coding gene. GO annotations related to this gene include cAMP binding and ubiquitin protein ligase binding. An important paralog of this gene is PRKAR1B.

UniProtKB/Swiss-Prot: KAP2_HUMAN, P13861
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

summary for PRKAR2A Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAR2A gene promoter:
         SRF   Egr-3   FOXF2   SRF (504 AA)   Pax-2   Pax-2a   CREB   AREB6   Pax-2b   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKAR2A promoter sequence
   Search Chromatin IP Primers for PRKAR2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAR2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3-p21.2   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3-p21.2

PRKAR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR2A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048782:  view genomic region     (about GC identifiers)

Start:
48,782,030 bp from pter      End:
48,885,279 bp from pter
Size:
103,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KAP2_HUMAN, P13861 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type II-alpha regulatory subunit  
Size: 404 amino acids; 45518 Da
Subunit: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation
by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts
with AKAP4 and CBFA2T3. Interacts with the phosphorylated form of PJA2. Interacts with MYRIP. This interaction
may link PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release
(By similarity)
2 PDB 3D structures from and Proteopedia for PRKAR2A:
2IZX (3D)        2KYG (3D)    
Secondary accessions: Q16823

Explore the universe of human proteins at neXtProt for PRKAR2A: NX_P13861

Explore proteomics data for PRKAR2A at MOPED

Post-translational modifications: 

  • Phosphorylated by the activated catalytic chain1
  • Ubiquitination2 at Lys345
  • Modification sites at PhosphoSitePlus

  • See PRKAR2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004148.1  
    ENSEMBL proteins: 
     ENSP00000409239   ENSP00000265563   ENSP00000394041   ENSP00000296446   ENSP00000400840  
     ENSP00000416438   ENSP00000411432  
    Reactome Protein details: P13861

    PRKAR2A Human Recombinant Protein Products:

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    antibodies-online proteins for PRKAR2A (9 products) 

     
    antibodies-online peptides for PRKAR2A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, regulatory, type II, alpha subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P13861

    ProtoNet protein and cluster: P13861

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP2_HUMAN, P13861
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    Find genes that share domains with PRKAR2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAP2_HUMAN, P13861
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II
    regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

         Genatlas biochemistry entry for PRKAR2A:
    protein kinase,cAMP dependent,regulatory type II,alpha subunit,ubiquitously expressed,interacting with A kinase
    anchoring proteins,necessary for cAMP dependent modulation of ion channels

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity IDA--
    GO:0005515protein binding IPI11278869
    GO:0008603cAMP-dependent protein kinase regulator activity NAS9003463
    GO:0016301kinase activity ----
    GO:0030552cAMP binding IEA--
         
    Find genes that share ontologies with PRKAR2A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRKAR2A:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Prkar2a):
     normal 

    Find genes that share phenotypes with PRKAR2A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prkar2atm1Gsm for PRKAR2A

       genOway: Develop your customized and physiologically relevant rodent model for PRKAR2A

    miRNA
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    miRTarBase miRNAs that target PRKAR2A:
    hsa-mir-155-5p (MIRT020699), hsa-mir-197-3p (MIRT004218), hsa-let-7b-5p (MIRT032313), hsa-mir-103a-3p (MIRT027082), hsa-mir-1260b (MIRT052717), hsa-mir-769-3p (MIRT039067), hsa-mir-16-5p (MIRT031655)

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    Selected qRT-PCR Assays for microRNAs that regulate PRKAR2A (see all 10):
    hsa-miR-365 hsa-miR-15a hsa-miR-4306 hsa-miR-497 hsa-miR-424 hsa-miR-185 hsa-miR-520g hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidPRKAR2A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAP2_HUMAN, P13861: Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--
    GO:0005952cAMP-dependent protein kinase complex IEA--

    Find genes that share ontologies with PRKAR2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKAR2A About   (see all 60)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    4G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    5Apoptosis (KEGG)
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37


    Find genes that share SuperPaths with PRKAR2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAR2A (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKAR2A (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PRKAR2A (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    TGF-beta Receptor Signaling Pathway

    Selected Reactome Pathways for PRKAR2A (see all 6)
        PKA activation
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    DARPP-32 events
    Factors involved in megakaryocyte development and platelet production
    Regulation of water balance by renal Aquaporins


    2 Kegg Pathways  (Kegg details for PRKAR2A):
        Apoptosis
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKAR2A: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAR2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAR2A (P138611, 2, 3 ENSP000002655634) via UniProtKB, MINT, STRING, and/or I2D (see all 286)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ----
    GO:0006112energy reserve metabolic process TAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with PRKAR2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKAR2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    1 HMDB Compound for PRKAR2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKAR2A gene: 
    NM_004157.2  

    Unigene Cluster for PRKAR2A:

    Protein kinase, cAMP-dependent, regulatory, type II, alpha
    Hs.631923  [show with all ESTs]
    Unigene Representative Sequence: BC002763
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457914 ENST00000265563(uc010hki.1 uc003cux.1 uc003cuy.1)
    ENST00000454963 ENST00000296446 ENST00000437821 ENST00000438535 ENST00000419216

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    Additional mRNA sequence: 

    AK023535.1 AK026351.1 AK293042.1 BC002763.2 BT007225.1 X14968.1 

    12 DOTS entries:

    DT.91759488  DT.95359512  DT.95359487  DT.100794095  DT.120905774  DT.120905776  DT.95359514  DT.100794091 
    DT.120905758  DT.75159725  DT.92424312  DT.120905763 

    Selected AceView cDNA sequences (see all 386):

    BU931522 AI679401 BU782532 AI357389 AI364150 AI208670 CK904341 CK904340 
    AI083840 BQ642946 AA428143 NM_004157 BQ058516 BM693821 CK430430 R80181 
    AA868780 CA424534 AU122430 AW327807 CA420074 AA741549 AI679908 AW079441 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                                                    
    SP2:                                                  -                                 
    SP3:                                                        -                           
    SP4:                                                                    -     -         
    SP5:        -                                                                           


    ECgene alternative splicing isoforms for PRKAR2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKAR2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGGCCCC
    PRKAR2A Expression
    About this image

    PRKAR2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAR2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631923

    UniProtKB/Swiss-Prot: KAP2_HUMAN, P13861
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their
    expression varies among tissues and is in some cases constitutive and in others inducible

        Pathway & Disease-focused RT2 Profiler PCR Array including PRKAR2A: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR2A gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkar2a1 , 5 protein kinase, cAMP dependent regulatory, type II more1, 5 87.07(n)1
    87.15(a)1
      9 (59.63 cM)5
    190871  NM_008924.21  NP_032950.11 
     1086921435 
    chicken
    (Gallus gallus)
    Aves LOC1008588271 cAMP-dependent protein kinase type II-alpha regulatory more 76.63(n)
    79.12(a)
      100858827  XM_003642006.2  XP_003642054.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAR2A6
    protein kinase, cAMP-dependent, regulatory, type I...
    82(a)
    1 ↔ 1
    2(187497896-187530099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkar2a1 protein kinase, cAMP-dependent, regulatory, type II, more 71.55(n)
    74.75(a)
      100486265  XM_002933058.2  XP_002933104.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkar2aa1 protein kinase, cAMP-dependent, regulatory, type II, more 70.58(n)
    72.96(a)
      556042  NM_001077370.2  NP_001070838.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-R21 cAMP-dependent protein kinase R2 56.45(n)
    52.92(a)
      36041  NM_165723.4  NP_724860.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCY1(YIL033C)4
    BCY11
    Regulatory subunit of the cyclic AMP-dependent protein more4
    BCY11
    51.38(n)1
    43.68(a)1
      9(291669-290419)4
    8547781, 4  NP_012231.11, 4 


    ENSEMBL Gene Tree for PRKAR2A (if available)
    TreeFam Gene Tree for PRKAR2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKAR2A gene
    PRKAR1B2  PRKAR2B2  PRKAR1A2  
    5 SIMAP similar genes for PRKAR2A using alignment to 6 protein entries:     KAP2_HUMAN (see all proteins):
    PRKAR2B    PRKAR1B    PRKAR1A    DKFZp779L0468    WUGSC

    Find genes that share paralogs with PRKAR2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKAR2A (see all 1366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599090651,2
    C--48786929(+) AAATA-/AATA/ 
    AATAAATA
    GGCCA
    1 -- int11NA 2
    rs1406767401,2
    --48787665(+) GTGGCA/GCATGC 1 -- ds50010--------
    rs1900471041,2
    --48787719(+) TTAATC/TTGGGA 1 -- ds50010--------
    rs1821179991,2
    --48787723(+) TCTGGA/GAGGCG 1 -- ds50010--------
    rs1424608261,2
    --48787751(+) AGACCA/GCACCA 1 -- ds50010--------
    rs1513133411,2
    --48787996(+) TTGATC/TGGTTC 1 -- ds50010--------
    rs1866562121,2
    --48788028(+) CTCTGA/GAGTAG 1 -- ds50010--------
    rs1171016281,2
    C,F--48788099(+) GGCAAC/TTGCAA 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs1915995831,2
    --48788858(+) CCTTTA/GGTGCT 1 -- ut310--------
    rs1824852331,2
    --48788913(+) AGTGGC/TGGCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKAR2A (48782030 - 48885279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRKAR2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1169569CNV Deletion17803354
    nsv508918CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKAR2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176910    OMIM disorders: --


    Find genes that share disorders with PRKAR2A           About GenesLikeMe

    Genetic Association Database (GAD): PRKAR2A
    Human Genome Epidemiology (HuGE) Navigator: PRKAR2A (2 documents)

    Export disorders for PRKAR2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKAR2A gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with PRKAR2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of PKA stability and signalling by the RING ligase praja2. (PubMed id 21423175)1, 2 Lignitto L.... Feliciello A. (Nat. Cell Biol. 2011)
    2. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. (PubMed id 11823486)1, 2 Schillace R.V.... Carr D.W. (J. Immunol. 2002)
    6. Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2. (PubMed id 9676433)1, 3 TaskAcn K....Jahnsen T. (Genomics 1998)
    7. Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase. (PubMed id 9003463)1, 2 Foss K.B.... Tasken K. (Biochim. Biophys. Acta 1997)
    8. Human testis cDNA for the regulatory subunit RII alpha of cAMP- dependent protein kinase encodes an alternate amino-terminal region. (PubMed id 2540040)1, 2 Oyen O.... Jahnsen T. (FEBS Lett. 1989)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. (PubMed id 23942052)1 Han Y.S....Ogut O. (Arch. Biochem. Biophys. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5576 HGNC: 9391 AceView: PRKAR2A Ensembl:ENSG00000114302 euGenes: HUgn5576
    ECgene: PRKAR2A Kegg: 5576 H-InvDB: PRKAR2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKAR2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKAR2A gene:
    Search GeneIP for patents involving PRKAR2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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