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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRKAR1B Gene

protein-coding GIFtS: 66
GCID: GC07M000588

protein kinase, cAMP-dependent, regulatory, type I, beta

Explore 14 diseases affiliated with
PRKAR1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta¹ ²
PRKAR1²
CAMP-Dependent Protein Kinase Type I-Beta Regulatory Subunit²

External Ids:	HGNC: 9390¹	Entrez Gene: 5575²	Ensembl: ENSG00000188191⁷	OMIM: 176911⁵	UniProtKB: P31321³

Export aliases for PRKAR1B gene to outside databases

Previous GC identifers: GC07U990076 GC17P067105 GC07M000491 GC07M000555 GC07M000507

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKAR1B:

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger

cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including

regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2

catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321

Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

summary for PRKAR1B:

Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose

metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is

composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the

regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit

releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the

transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific

sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRKAR1B gene promoter:
Pax-5 Egr-1 HSF1 (long) Egr-4 Arnt CREB deltaCREB HSF1short ARP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRKAR1B promoter sequence

Search SABiosciences Chromatin IP Primers for PRKAR1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAR1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7pter-p22

PRKAR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR1B gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M000588: view genomic region (about GC identifiers)

Start:	588,834 bp from pter	End:	767,313 bp from pter
Size:	178,480 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 650,549-825,534

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321 (See protein sequence)

Recommended Name: cAMP-dependent protein kinase type I-beta regulatory subunit

Size: 381 amino acids; 43073 Da

Subunit: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP

releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this

cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma

membrane

Subcellular location: Cell membrane

2 PDB 3D structures from and Proteopedia for PRKAR1B:

4DIN (3D)

4F9K (3D)

Secondary accessions: Q8N422

Explore the universe of human proteins at neXtProt for PRKAR1B: NX_P31321

Post-translational modifications:

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the

inhibition of its activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31321

PRKAR1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001158230.1 NP_001158231.1 NP_001158232.1 NP_001158233.1 NP_001158234.1 NP_002726.1

ENSEMBL proteins:

ENSP00000385749 ENSP00000385349 ENSP00000353415 ENSP00000383569 ENSP00000402648

ENSP00000394633 ENSP00000406670 ENSP00000410414 ENSP00000440449 ENSP00000444487

Reactome Protein details: P31321
Human Recombinant Protein Products for PRKAR1B:

	EMD Millipore Purified and/or Recombinant PRKAR1B Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PRKAR1B OriGene Protein Over-expression Lysate (see all 6): PRKAR1B OriGene Custom Protein Services for PRKAR1B
	GenScript Custom Purified and Recombinant Proteins Services for PRKAR1B
	Novus Biologicals PRKAR1B Protein Novus Biologicals PRKAR1B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005626	insoluble fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--

PRKAR1B for ontologies About GeneDecksing

PRKAR1B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies (see all 4): PRKAR1B OriGene Custom Antibody Services for PRKAR1B
	GenScript Superior Antibodies for PRKAR1B
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	ThermoFisher Antibodies for PRKAR1B

Assay Products for PRKAR1B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PRKAR1B
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRKAR1B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003117 cAMP_dep_PK_reg_su_I/II_a/b

IPR018488 cNMP-bd_CS

IPR018490 cNMP-bd-like

IPR000595 cNMP-bd_dom

IPR012198 cAMP_dep_PK_reg_su

Graphical View of Domain Structure for InterPro Entry P31321

ProtoNet protein and cluster: P31321

3 Blocks protein families:

IPB000595 Cyclic nucleotide-binding domain

IPB002373 cAMP-dependent protein kinase signature

IPB003117 cAMP-dependent protein kinase regulator

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321

Similarity: Belongs to the cAMP-dependent kinase regulatory chain family

Similarity: Contains 2 cyclic nucleotide-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KAP1_HUMAN, P31321

Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

Genatlas biochemistry entry for PRKAR1B:

protein kinase,cAMP-dependent,type I,beta subunit,regulatory polypeptide

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008603	cAMP-dependent protein kinase regulator activity	NAS	1708242
GO:0030552	cAMP binding	IEA	--

PRKAR1B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PRKAR1B:

Synthetic lethal with Ras

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prkar1b):

behavior/neurological

immune system

integument

nervous system

PRKAR1B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Prkar1b^tm1Gsm for PRKAR1B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRKAR1B

miRNA Products:		OriGene 3'-UTR Clone (see all 6): PRKAR1B Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAR1B:
		hsa-miR-92a hsa-miR-363 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-92b
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAR1B (see all 7) OriGene shRNA RFP: PRKAR1B OriGene siRNA: PRKAR1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAR1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKAR1B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PRKAR1B
			Sirion Biotech Customized adenovirus for overexpression of PRKAR1B Sirion Biotech Customized adenovirus for potent knockdown of PRKAR1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1B (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1B (see all 8) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): PRKAR1B (NM_002735)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/66 super-pathways (see all 66) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PKA activation in glucagon signalling

8/12 pathways (see all 12)
PKA activation in glucagon signalling	1.00	Neurophysiological process_PGE2-induced pain processing	0.44
PKA activation	0.94	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling	0.37
PKA-mediated phosphorylation of CREB	0.89	Development_Role of Activin A in cell differentiation and proliferation	0.33
Regulation of CFTR gating (normal and CF)	0.76	Development Role of Activin A in cell differentiation and proliferation	0.33

DAG and IP3 signaling

DAG and IP3 signaling	1.00	CaM pathway	0.84
PLC-gamma1 signalling	0.94	Calmodulin induced events	0.84
EGFR interacts with phospholipase C-gamma	0.94	Ca-dependent events	0.79
PLCG1 events in ERBB2 signaling	0.91	Phospholipase C-mediated cascade	0.57

G-protein signaling_G-Protein alpha-i signaling cascades

G-protein signaling_G-Protein alpha-i signaling cascades	1.00	Development Beta-adrenergic receptors regulation of ERK	0.55
G-protein signaling G-Protein alpha-i signaling cascades	1.00	G-protein signaling_G-Protein alpha-s signaling cascades	0.44
Development_Beta-adrenergic receptors regulation of ERK	0.55	G-protein signaling G-Protein alpha-s signaling cascades	0.44

G Protein Signaling Pathways

G Protein Signaling Pathways	1.00	Signal transduction_PKA signaling	0.23
Signal transduction cAMP signaling	0.44	Signal transduction PKA signaling	0.23
Signal transduction_cAMP signaling	0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

5/26 EMD Millipore Pathways for PRKAR1B (see all 26)

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development A1 receptor signaling
	Development Ligand-independent activation of ESR1 and ESR2
	Transcription PPAR Pathway

5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAR1B (see all 52)

	Nuclear Receptor Activation by Vitamin-A
	14-3-3 Induced Apoptosis
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	CDK5 Pathway

2 Cell Signaling Technology (CST) Pathways for PRKAR1B

	Ca, cAMP and Lipid Signaling
	Neuroscience

5/32 GeneGo (Thomson Reuters) Pathways for PRKAR1B (see all 32)

	Development A2A receptor signaling
	Signal transduction cAMP signaling
	Transcription PPAR Pathway
	G-protein signaling G-Protein alpha-i signaling cascades
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

5/6 BioSystems Pathways for PRKAR1B (see all 6)

	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	SIDS Susceptibility Pathways
	Calcium Regulation in the Cardiac Cell
	TGF-beta Receptor Signaling Pathway

5/42 Reactome Pathways for PRKAR1B (see all 42)

	PKA activation
	Signaling by EGFR in Cancer
	DARPP-32 events
	Downstream signal transduction
	Signal Transduction

2 Kegg Pathways (Kegg details for PRKAR1B):

	Apoptosis
	Insulin signaling pathway

PRKAR1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRKAR1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for PRKAR1B (P31321^{2, 3} ENSP00000353415⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKAR1A	P10644³, ENSP00000351410⁴	I2D: score=3 STRING: ENSP00000351410
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=2 STRING: ENSP00000332973
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=1 STRING: ENSP00000324897
AKAP1	Q92667³, ENSP00000337736⁴	I2D: score=3 STRING: ENSP00000337736

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006468	protein phosphorylation	NAS	1708242
GO:0006833	water transport	TAS	--
GO:0007165	signal transduction	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

PRKAR1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PRKAR1B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PRKAR1B available from Tocris Bioscience About this table

Compound	Action	CAS #
H 89 dihydrochloride	Protein kinase A inhibitor	[127243-85-0]
8-Bromo-cAMP, sodium salt	Cell-permeable cAMP analog	[76939-46-3]
cAMPS-Rp, triethylammonium salt	cAMP antagonist	[73208-40-9]
KT 5720	Selective protein kinase A inhibitor	[108068-98-0]
Dibutyryl-cAMP, sodium salt	Cell-permeable cAMP analog	[16980-89-5]

1 HMDB Compound for PRKAR1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

Search CenterWatch for drugs/clinical trials and news about PRKAR1B / KAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRKAR1B gene (6 alternative transcripts):

NM_001164758.1 NM_001164759.1 NM_001164760.1 NM_001164761.1 NM_001164762.1 NM_002735.2

Unigene Cluster for PRKAR1B:

Protein kinase, cAMP-dependent, regulatory, type I, beta

Hs.520851 [show with all ESTs]

Unigene Representative Sequence: NM_001164761

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000406797(uc003siv.3) ENST00000403562 ENST00000360274 ENST00000400758(uc003six.1)

ENST00000430040 ENST00000414568 ENST00000417852 ENST00000488474 ENST00000456696

ENST00000478198 ENST00000537384(uc021zyj.1) ENST00000544935(uc003siu.2 uc021zyi.1 uc021zyk.1 uc003siw.2)

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAR1B:
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAR1B (see all 7) OriGene shRNA RFP: PRKAR1B OriGene siRNA: PRKAR1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAR1B
		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKAR1B

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		GenScript: all cDNA clones in your preferred vector (see all 6): PRKAR1B (NM_002735)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAR1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRKAR1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAR1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAR1B

Additional cDNA sequence:

AK098822.1 AK124153.1 AK289464.1 AK297337.1 AK315951.1 AK315990.1 AL833563.1 BC013368.2

BC026734.1 BC036828.1 BC070478.1 M65066.1

23 DOTS entries:

DT.86842826 DT.100028667 DT.449530 DT.100882718 DT.100785149 DT.97854140 DT.92427825 DT.95372126

DT.97854138 DT.422588 DT.121111468 DT.101969024 DT.121111513 DT.91893720 DT.95100163 DT.100882710

DT.121111381 DT.121111459 DT.121111484 DT.40127267 DT.75115664 DT.97807535 DT.95372130

24/83 AceView cDNA sequences (see all 83):

AL047457 BX395406 BX459980 BM924084 BX440329 BQ067119 BX461088 BI598242

BX422448 BM800464 BX428117 BX385235 AL711491 BM545135 BX401114 BX442296

AU117287 BQ637910 BX376816 BM927320 BQ882361 BX374447 AW732869 AW160661

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRKAR1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCATTAAA

About this image

PRKAR1B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Eye

Gut Tube

Neural Tube

Neural Tube

Spinal Dorsal Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRKAR1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAR1B

SOURCE GeneReport for Unigene cluster: Hs.520851

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321

Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression

varies among tissues and is in some cases constitutive and in others inducible

SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAR1B:

Circadian Rhythms in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAR1B Browse OriGene validated miRNA SYBR primer pairs
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRKAR1B gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRKAR1B¹	protein kinase, cAMP-dependent, regulatory, type I, more	80.49(n) 93.18(a)		416446 XM_414754.3 XP_414754.1
lizard (Anolis carolinensis)	Reptilia	PRKAR1B⁶	--	90(a)	1 ↔ 1	GL343385.1(578996-632377)
zebrafish (Danio rerio)	Actinopterygii	prkar1b¹	protein kinase, cAMP-dependent, regulatory, type I, more	82.44(n) 94.62(a)		767685 NM_001076623.1 NP_001070091.1
fruit fly (Drosophila melanogaster)	Insecta	Pka-R1⁶	cAMP-dependent protein kinase R1	54(a)	1 → many	3L(20809218-20829148)
worm (Caenorhabditis elegans)	Secernentea	kin-2¹	Protein KIN-2	58.96(n) 59.61(a)		180864 NM_001083302.1 NP_001076771.1

ENSEMBL Gene Tree for PRKAR1B (if available)
TreeFam Gene Tree for PRKAR1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRKAR1B gene

PRKAR2A² PRKAR2B² PRKAR1A²

9 SIMAP similar genes for PRKAR1B using alignment to 7 protein entries: KAP1_HUMAN (see all proteins):

DKFZp779L0468 RET/PTC2 PRKAR1A PRKAR1A/RARA fusion PRKAR2A PRKG1

PRKAR2B PRKG2 WUGSC

PRKAR1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9330399^1,2	C,F	--	588334(+)	`ACAGTG/ACAGAG`	6	--	ds500¹		4		NA CSA	8
rs141243027^1,2		--	588354(+)	`TGGGCA/CCCGTC`	6	--	ds500¹		0	--	--	--	--
rs145566459^1,2		--	588357(+)	`GCCCCA/GTCTAC`	6	--	ds500¹		0	--	--	--	--
rs9330400^1,2	C,F	--	588423(+)	`GCTCAA/TATGAG`	6	--	ds500¹		8		NA WA CSA	13
rs188311625^1,2		--	588434(+)	`AACGTC/TTGGAT`	6	--	ds500¹		0	--	--	--	--
rs193280841^1,2		--	588478(+)	`GACAAC/TGCTCA`	6	--	ds500¹		0	--	--	--	--
rs141990426^1,2		--	588504(+)	`ATACAC/TAGGGC`	6	--	ds500¹		0	--	--	--	--
rs146301302^1,2		--	588584(+)	`GTGGAC/TGGGTG`	6	--	ds500¹		0	--	--	--	--
rs185444056^1,2		--	588617(+)	`GCTGTC/TGTTTA`	6	--	ds500¹		0	--	--	--	--
rs139323053^1,2		--	588651(+)	`GAAGAA/TGAAAG`	6	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRKAR1B (588834 - 767313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for PRKAR1B
6 CNVs: 69743 94323 81832 69741 94324 94325
10 Indels: 94320 69742 64733 94318 81831 43172 94319 28663 94321 94322

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRKAR1B for disorders           About GeneDecksing

OMIM gene information: 176911    OMIM disorders: --

14 diseases for PRKAR1B:    About MalaCards

dengue hemorrhagic fever familial atrial fibrillation hemorrhagic fever atrial fibrillation

systemic lupus erythematosus lupus erythematosus bloom syndrome pituitary adenoma

neurologic diseases adenoma immunodeficiency malaria

colorectal cancer breast cancer

1 disease from the University of Copenhagen DISEASES database for PRKAR1B:

Familial atrial fibrillation

Human Genome Epidemiology (HuGE) Navigator: PRKAR1B (2 documents)

Export disorders for PRKAR1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRKAR1B gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with PRKAR1B)

Utopia: connect your pdf to the dynamic
world of online information

Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)^{1, 2, 9} Zhan X. and Desiderio D.M. (2006)
Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. (PubMed id 7925653)^{1, 2} Solberg R.... Taylor S.S. (1994)
Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PubMed id 1358799)^{1, 3} Solberg R....de la Chapelle A. (1992)
Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. (PubMed id 1708242)^{1, 2} Solberg R.... Jahnsen T. (1991)
Exclusion of catalytic and regulatory subunits of cAM P-dependent protein kinase as candidate genes for the defect causing cystic fib rosis. (PubMed id 3479018)^{1, 3} Scambler P....Jahnsen T. (1987)
A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. (PubMed id 23115245)² Burgers P.P.... Heck A.J. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Role of phosphorylation in the nuclear biology of HIV- 1. (PubMed id 21651489)¹ Francis A.C....Cereseto A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5575	HGNC: 9390	AceView: PRKAR1B	Ensembl:ENSG00000188191	euGenes: HUgn5575
ECgene: PRKAR1B	Kegg: 5575	H-InvDB: PRKAR1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRKAR1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRKAR1B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRKAR1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PRKAR1B gene:
Search GeneIP for patents involving PRKAR1B

GeneCards and IP:
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PRKAR1B Gene

protein kinase, cAMP-dependent, regulatory, type I, beta

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PRKAR1B Gene

protein kinase, cAMP-dependent, regulatory, type I, beta

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