Aliases for PRKAR1B Gene
External Ids for PRKAR1B Gene
Previous GeneCards Identifiers for PRKAR1B Gene
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
GeneCards Summary for PRKAR1B Gene
PRKAR1B (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta) is a Protein Coding gene. Diseases associated with PRKAR1B include Prkar1b-Related Neurodegenerative Dementia With Intermediate Filaments and Carney Complex Variant. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Development A2B receptor- action via G-protein alpha s. GO annotations related to this gene include cAMP binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR2B.
UniProtKB/Swiss-Prot for PRKAR1B Gene
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.