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PRKAR1B Gene

protein-coding   GIFtS: 67
GCID: GC07M000588

Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta

  See PRKAR1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta1 2
PRKAR12
CAMP-Dependent Protein Kinase Type I-Beta Regulatory Subunit2

External Ids:    HGNC: 93901   Entrez Gene: 55752   Ensembl: ENSG000001881917   OMIM: 1769115   UniProtKB: P313213   

Export aliases for PRKAR1B gene to outside databases

Previous GC identifers: GC07U990076 GC17P067105 GC07M000491 GC07M000555 GC07M000507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKAR1B Gene:
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second
messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell
including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2
regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.(supplied
by OMIM, Jun 2009)

GeneCards Summary for PRKAR1B Gene:
PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta) is a protein-coding gene. Diseases associated with PRKAR1B include familial atrial fibrillation. GO annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR2A.

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

summary for PRKAR1B Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAR1B gene promoter:
         Pax-5   Egr-1   HSF1 (long)   Egr-4   Arnt   CREB   deltaCREB   HSF1short   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRKAR1B promoter sequence
   Search Chromatin IP Primers for PRKAR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

PRKAR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR1B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000588:  view genomic region     (about GC identifiers)

Start:
588,834 bp from pter      End:
767,313 bp from pter
Size:
178,480 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 650,549-825,534     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type I-beta regulatory subunit  
Size: 381 amino acids; 43073 Da
Subunit: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP
releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this
cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma
membrane
2 PDB 3D structures from and Proteopedia for PRKAR1B:
4DIN (3D)        4F9K (3D)    
Secondary accessions: Q8N422

Explore the universe of human proteins at neXtProt for PRKAR1B: NX_P31321

Explore proteomics data for PRKAR1B at MOPED

Post-translational modifications: 

  • The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the
    inhibition of its activity1
  • Ubiquitination2 at Lys244, Lys261, Lys349
  • Modification sites at PhosphoSitePlus

  • See PRKAR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001158230.1  NP_001158231.1  NP_001158232.1  NP_001158233.1  NP_001158234.1  NP_002726.1  

    ENSEMBL proteins: 
     ENSP00000385749   ENSP00000385349   ENSP00000353415   ENSP00000383569   ENSP00000402648  
     ENSP00000394633   ENSP00000406670   ENSP00000410414   ENSP00000440449   ENSP00000444487  
    Reactome Protein details: P31321

    PRKAR1B Human Recombinant Protein Products:

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    Novus Biologicals PRKAR1B Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRKAR1B 

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    Novus Biologicals PRKAR1B Antibodies
    Abcam antibodies for PRKAR1B
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    LSBio Antibodies in human, mouse, rat for PRKAR1B

    PRKAR1B Assay Products:

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    Search eBioscience for ELISAs for PRKAR1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, regulatory, type I, beta subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P31321

    ProtoNet protein and cluster: P31321

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    Find genes that share domains with PRKAR1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAP1_HUMAN, P31321
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

         Genatlas biochemistry entry for PRKAR1B:
    protein kinase,cAMP-dependent,type I,beta subunit,regulatory polypeptide

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity IDA--
    GO:0008603cAMP-dependent protein kinase regulator activity NAS1708242
    GO:0030552cAMP binding IEA--
    GO:0034236protein kinase A catalytic subunit binding IPI--
         
    Find genes that share ontologies with PRKAR1B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PRKAR1B:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prkar1b):
     behavior/neurological  immune system  integument  nervous system 

    Find genes that share phenotypes with PRKAR1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prkar1btm1Gsm for PRKAR1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKAR1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKAR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAR1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKAR1B

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    hsa-miR-92a hsa-miR-363 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 6): PRKAR1B (NM_002735)
    Sino Biological Human cDNA Clone for PRKAR1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAR1B
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    Addgene plasmids for PRKAR1B 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAP1_HUMAN, P31321: Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005952cAMP-dependent protein kinase complex NAS1708242

    Find genes that share ontologies with PRKAR1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKAR1B About   (see all 62)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    4G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    5Apoptosis (KEGG)
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37


    Find genes that share SuperPaths with PRKAR1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAR1B (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for PRKAR1B
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for PRKAR1B (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PRKAR1B (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for PRKAR1B (see all 6)
        PKA activation
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    DARPP-32 events
    Factors involved in megakaryocyte development and platelet production
    Regulation of water balance by renal Aquaporins


    2 Kegg Pathways  (Kegg details for PRKAR1B):
        Apoptosis
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAR1B: 
              Circadian Rhythms in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAR1B (P313212, 3 ENSP000003534154) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106443, ENSP000003514104I2D: score=3 STRING: ENSP00000351410
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    AKAP1Q926673, ENSP000003377364I2D: score=3 STRING: ENSP00000337736
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    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ----
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation NAS1708242
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--

    Find genes that share ontologies with PRKAR1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKAR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    1 HMDB Compound for PRKAR1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKAR1B gene (6 alternative transcripts): 
    NM_001164758.1  NM_001164759.1  NM_001164760.1  NM_001164761.1  NM_001164762.1  NM_002735.2  

    Unigene Cluster for PRKAR1B:

    Protein kinase, cAMP-dependent, regulatory, type I, beta
    Hs.520851  [show with all ESTs]
    Unigene Representative Sequence: NM_001164761
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406797(uc003siv.3) ENST00000403562 ENST00000360274 ENST00000400758(uc003six.1)
    ENST00000430040 ENST00000414568 ENST00000417852 ENST00000456696 ENST00000488474
    ENST00000478198 ENST00000537384(uc021zyj.1) ENST00000544935(uc003siu.2 uc021zyi.1 uc021zyk.1 uc003siw.2)

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    hsa-miR-92a hsa-miR-363 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 6): PRKAR1B (NM_002735)
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      QuantiTect SYBR Green Assays in human, mouse, rat PRKAR1B
      QuantiFast Probe-based Assays in human, mouse, rat PRKAR1B

    Additional mRNA sequence: 

    AK098822.1 AK124153.1 AK289464.1 AK297337.1 AK315951.1 AK315990.1 AL833563.1 BC013368.2 
    BC026734.1 BC036828.1 BC070478.1 M65066.1 

    23 DOTS entries:

    DT.86842826  DT.100028667  DT.449530  DT.100882718  DT.100785149  DT.97854140  DT.92427825  DT.95372126 
    DT.97854138  DT.422588  DT.121111468  DT.101969024  DT.121111513  DT.91893720  DT.95100163  DT.100882710 
    DT.121111381  DT.121111459  DT.121111484  DT.40127267  DT.75115664  DT.97807535  DT.95372130 

    Selected AceView cDNA sequences (see all 83):

    BM924084 BX459980 AL047457 BX395406 BM800464 BX401114 BQ067119 BX385235 
    AW160661 BQ882361 AU117287 AW732869 BX440329 BX376816 AL711491 BX442296 
    BX422448 BX428117 BI598242 BQ637910 BX374447 BX461088 BM545135 BM927320 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKAR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCATTAAA
    PRKAR1B Expression
    About this image


    PRKAR1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
    PRKAR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520851

    UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their
    expression varies among tissues and is in some cases constitutive and in others inducible

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAR1B: 
              Circadian Rhythms in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkar1b1 , 5 protein kinase, cAMP dependent regulatory, type I beta1, 5 85.91(n)1
    94.75(a)1
      5 (77.74 cM)5
    190851  NM_001253890.11  NP_001240819.11 
     1390173065 
    chicken
    (Gallus gallus)
    Aves PRKAR1B1 protein kinase, cAMP-dependent, regulatory, type I, more 80.49(n)
    93.18(a)
      416446  XM_004945114.1  XP_004945171.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAR1B6
    protein kinase, cAMP-dependent, regulatory, type I...
    91(a)
    1 ↔ 1
    GL343385.1(577728-634758)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkar1b1 protein kinase, cAMP-dependent, regulatory, type I,beta 77.72(n)
    93.8(a)
      780384  NM_001079454.1  NP_001072922.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkar1b1 protein kinase, cAMP-dependent, regulatory, type I, more 82.44(n)
    94.62(a)
      767685  NM_001076623.1  NP_001070091.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-R16
    cAMP-dependent protein kinase R1
    54(a)
    1 → many
    3L(20809218-20829148)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-21 kin-2 58.96(n)
    59.61(a)
      180864  NM_001083302.1  NP_001076771.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCY16
    Regulatory subunit of the cyclic AMP-dependent pro...
    29(a)
    1 → many
    IX(290419-291669) YIL033C


    ENSEMBL Gene Tree for PRKAR1B (if available)
    TreeFam Gene Tree for PRKAR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKAR1B gene
    PRKAR2A2  PRKAR2B2  PRKAR1A2  
    9 SIMAP similar genes for PRKAR1B using alignment to 7 protein entries:     KAP1_HUMAN (see all proteins):
    RET/PTC2    DKFZp779L0468    PRKAR1A    PRKAR1A/RARA fusion    PRKAR2A    PRKG1
    PRKAR2B    PRKG2    WUGSC

    Find genes that share paralogs with PRKAR1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKAR1B (see all 4876)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93303991,2
    C,F--588334(+) ACAGTG/ACAGAG 6 -- ds50014Minor allele frequency- A:0.38NA CSA 8
    rs1412430271,2
    --588354(+) TGGGCA/CCCGTC 6 -- ds50010--------
    rs1455664591,2
    --588357(+) GCCCCA/GTCTAC 6 -- ds50010--------
    rs93304001,2
    C,F--588423(+) GCTCAA/TATGAG 6 -- ds50018Minor allele frequency- T:0.23NA WA CSA 13
    rs1883116251,2
    --588434(+) AACGTC/TTGGAT 6 -- ds50010--------
    rs1932808411,2
    --588478(+) GACAAC/TGCTCA 6 -- ds50010--------
    rs1419904261,2
    --588504(+) ATACAC/TAGGGC 6 -- ds50010--------
    rs1463013021,2
    C--588584(+) GTGGAC/TGGGTG 6 -- ds50010--------
    rs1854440561,2
    --588617(+) GCTGTC/TGTTTA 6 -- ds50010--------
    rs1393230531,2
    C--588651(+) GAAGAA/TGAAAG 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRKAR1B (588834 - 767313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKAR1B (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667360CNV Deletion23128226
    esv2733652CNV Deletion23290073
    esv2733647CNV Deletion23290073
    esv2733631CNV Deletion23290073
    esv2733646CNV Deletion23290073
    esv3069CNV Deletion18987735
    esv2733626CNV Deletion23290073
    esv2733634CNV Deletion23290073
    esv1697450CNV Deletion17803354
    esv2733645CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176911    OMIM disorders: --

    1 disease for PRKAR1B:    
    About MalaCards
    familial atrial fibrillation

    1 disease from the University of Copenhagen DISEASES database for PRKAR1B:
    Familial atrial fibrillation

    Find genes that share disorders with PRKAR1B           About GenesLikeMe

    Genetic Association Database (GAD): PRKAR1B
    Human Genome Epidemiology (HuGE) Navigator: PRKAR1B (2 documents)

    Export disorders for PRKAR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKAR1B gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with PRKAR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (Anal. Biochem. 2006)
    2. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    3. Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. (PubMed id 7925653)1, 2 Solberg R.... Taylor S.S. (Exp. Cell Res. 1994)
    4. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PubMed id 1358799)1, 3 Solberg R....de la Chapelle A. (Genomics 1992)
    5. Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. (PubMed id 1708242)1, 2 Solberg R.... Jahnsen T. (Biochem. Biophys. Res. Commun. 1991)
    6. Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis. (PubMed id 3479018)1, 3 Scambler P....Jahnsen T. (Am. J. Hum. Genet. 1987)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. (PubMed id 23115245)2 Burgers P.P.... Heck A.J. (J. Biol. Chem. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5575 HGNC: 9390 AceView: PRKAR1B Ensembl:ENSG00000188191 euGenes: HUgn5575
    ECgene: PRKAR1B Kegg: 5575 H-InvDB: PRKAR1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKAR1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAR1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKAR1B gene:
    Search GeneIP for patents involving PRKAR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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