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Aliases for PRKAR1B Gene

Aliases for PRKAR1B Gene

  • Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta 2 3 5
  • Protein Kinase, CAMP-Dependent, Regulatory Subunit Type I Beta 2 3
  • Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta 2 3
  • CAMP-Dependent Protein Kinase Type I-Beta Regulatory Subunit 3
  • PRKAR1 3

External Ids for PRKAR1B Gene

Previous GeneCards Identifiers for PRKAR1B Gene

  • GC07U990076
  • GC17P067105
  • GC07M000491
  • GC07M000555
  • GC07M000507

Summaries for PRKAR1B Gene

Entrez Gene Summary for PRKAR1B Gene

  • The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for PRKAR1B Gene

PRKAR1B (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta) is a Protein Coding gene. Diseases associated with PRKAR1B include Prkar1b-Related Neurodegenerative Dementia With Intermediate Filaments and Carney Complex Variant. Among its related pathways are DAG and IP3 signaling and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include cAMP binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR1A.

UniProtKB/Swiss-Prot for PRKAR1B Gene

  • Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Tocris Summary for PRKAR1B Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKAR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAR1B Gene

Genomics for PRKAR1B Gene

Regulatory Elements for PRKAR1B Gene

Enhancers for PRKAR1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F000767 0.6 ENCODE 30.8 -41.0 -41033 2.2 CTCF SIN3A ZBTB33 REST RAD21 DNAAF5 PRKAR1B GPR146 C7orf50 PRSS3P2 GC07M000740
GH07F000729 0.6 ENCODE 22.9 -4.0 -3993 3.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 DNAAF5 PRKAR1B GC07P000738
GH07F000725 0.2 ENCODE 21.5 +0.9 865 3.2 HDGF ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 DNAAF5 PRKAR1B MAFK
GH07F000770 1.1 Ensembl ENCODE 19.8 -43.8 -43849 2.4 ATF1 KLF1 PKNOX1 ZNF121 ZNF316 ZFHX2 NFE2 TRIM24 CREM EGR2 DNAAF5 PRKAR1B GPR146 C7orf50 PRSS3P2 GC07M000740
GH07F000797 0.5 ENCODE 19.4 -70.3 -70289 1.0 CTCF PRKAR1B DNAAF5 GC07P000799 TRY7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRKAR1B on UCSC Golden Path with GeneCards custom track

Promoters for PRKAR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620529 576 1801 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207

Genomic Location for PRKAR1B Gene

Chromosome:
7
Start:
549,196 bp from pter
End:
727,676 bp from pter
Size:
178,481 bases
Orientation:
Minus strand

Genomic View for PRKAR1B Gene

Genes around PRKAR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAR1B Gene

Proteins for PRKAR1B Gene

  • Protein details for PRKAR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31321-KAP1_HUMAN
    Recommended name:
    cAMP-dependent protein kinase type I-beta regulatory subunit
    Protein Accession:
    P31321
    Secondary Accessions:
    • Q8N422

    Protein attributes for PRKAR1B Gene

    Size:
    381 amino acids
    Molecular mass:
    43073 Da
    Quaternary structure:
    • The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma membrane.

    Three dimensional structures from OCA and Proteopedia for PRKAR1B Gene

neXtProt entry for PRKAR1B Gene

Post-translational modifications for PRKAR1B Gene

  • The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Ubiquitination at Lys 261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRKAR1B Gene

Domains & Families for PRKAR1B Gene

Suggested Antigen Peptide Sequences for PRKAR1B Gene

Graphical View of Domain Structure for InterPro Entry

P31321

UniProtKB/Swiss-Prot:

KAP1_HUMAN :
  • Contains 2 cyclic nucleotide-binding domains.
  • Belongs to the cAMP-dependent kinase regulatory chain family.
Domain:
  • Contains 2 cyclic nucleotide-binding domains.
Family:
  • Belongs to the cAMP-dependent kinase regulatory chain family.
genes like me logo Genes that share domains with PRKAR1B: view

Function for PRKAR1B Gene

Molecular function for PRKAR1B Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,type I,beta subunit,regulatory polypeptide
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Gene Ontology (GO) - Molecular Function for PRKAR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004862 cAMP-dependent protein kinase inhibitor activity IDA 21812984
GO:0005515 protein binding IPI 23455922
GO:0008603 cAMP-dependent protein kinase regulator activity NAS,IDA 1708242
GO:0030552 cAMP binding IEA --
GO:0034236 protein kinase A catalytic subunit binding IPI 21812984
genes like me logo Genes that share ontologies with PRKAR1B: view
genes like me logo Genes that share phenotypes with PRKAR1B: view

Animal Models for PRKAR1B Gene

MGI Knock Outs for PRKAR1B:

Animal Model Products

miRNA for PRKAR1B Gene

miRTarBase miRNAs that target PRKAR1B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAR1B Gene

Localization for PRKAR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAR1B Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAR1B Gene COMPARTMENTS Subcellular localization image for PRKAR1B gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRKAR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005952 cAMP-dependent protein kinase complex NAS 1708242
GO:0016020 membrane IEA --
GO:0097546 ciliary base TAS --
genes like me logo Genes that share ontologies with PRKAR1B: view

Pathways & Interactions for PRKAR1B Gene

SuperPathways for PRKAR1B Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
2 RET signaling
3 G-Beta Gamma Signaling
4 Aquaporin-mediated transport
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with PRKAR1B: view

Gene Ontology (GO) - Biological Process for PRKAR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003091 renal water homeostasis TAS --
GO:0006468 protein phosphorylation NAS 1708242
GO:0007596 blood coagulation TAS --
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with PRKAR1B: view

No data available for SIGNOR curated interactions for PRKAR1B Gene

Drugs & Compounds for PRKAR1B Gene

(5) Drugs for PRKAR1B Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
KT 5720 Pharma Positive, Allosteric regulator Selective protein kinase A inhibitor 0
cAMPS-Sp, triethylammonium salt Pharma Cell-permeable cAMP analog 0
PKA inhibitor fragment (6-22) amide Pharma Potent protein kinase A inhibitor 0
PKI 14-22 amide, myristoylated Pharma PKA inhibitor, Cell-permeable protein kinase A inhibitor 0

(1) Additional Compounds for PRKAR1B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
H 89 dihydrochloride
130964-39-5

(5) Tocris Compounds for PRKAR1B Gene

Compound Action Cas Number
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog 93602-66-5
H 89 dihydrochloride Protein kinase A inhibitor 130964-39-5
KT 5720 Selective protein kinase A inhibitor 108068-98-0
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor 121932-06-7
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor 201422-03-9

(1) ApexBio Compounds for PRKAR1B Gene

Compound Action Cas Number
KT 5720 108068-98-0
genes like me logo Genes that share compounds with PRKAR1B: view

Transcripts for PRKAR1B Gene

Unigene Clusters for PRKAR1B Gene

Protein kinase, cAMP-dependent, regulatory, type I, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR1B Gene

No ASD Table

Relevant External Links for PRKAR1B Gene

GeneLoc Exon Structure for
PRKAR1B
ECgene alternative splicing isoforms for
PRKAR1B

Expression for PRKAR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRKAR1B Gene

mRNA differential expression in normal tissues according to GTEx for PRKAR1B Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Anterior cingulate cortex (BA24) (x5.4).

Protein differential expression in normal tissues from HIPED for PRKAR1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Heart (11.2), Fetal Brain (8.7), and Ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKAR1B Gene



NURSA nuclear receptor signaling pathways regulating expression of PRKAR1B Gene:

PRKAR1B

SOURCE GeneReport for Unigene cluster for PRKAR1B Gene:

Hs.520851

mRNA Expression by UniProt/SwissProt for PRKAR1B Gene:

P31321-KAP1_HUMAN
Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
genes like me logo Genes that share expression patterns with PRKAR1B: view

Primer Products

No data available for Protein tissue co-expression partners for PRKAR1B Gene

Orthologs for PRKAR1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKAR1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRKAR1B 34 35
  • 87.62 (n)
cow
(Bos Taurus)
Mammalia PRKAR1B 34 35
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Prkar1b 34 16 35
  • 85.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAR1B 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkar1b 34
  • 84.52 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKAR1B 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKAR1B 34 35
  • 80.49 (n)
lizard
(Anolis carolinensis)
Reptilia PRKAR1B 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkar1b 34
  • 77.72 (n)
zebrafish
(Danio rerio)
Actinopterygii prkar1b 34 35
  • 82.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pka-R1 35
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-2 34 35
  • 58.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCY1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8266 35
  • 62 (a)
OneToMany
Species where no ortholog for PRKAR1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAR1B Gene

ENSEMBL:
Gene Tree for PRKAR1B (if available)
TreeFam:
Gene Tree for PRKAR1B (if available)

Paralogs for PRKAR1B Gene

Paralogs for PRKAR1B Gene

genes like me logo Genes that share paralogs with PRKAR1B: view

Variants for PRKAR1B Gene

Sequence variations from dbSNP and Humsavar for PRKAR1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs557885420 Likely benign 726,747(+) GAGGC(C/T)GTGGC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs78581255 Likely benign 727,197(+) GCCGC(A/G)CTCGC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs878855037 Likely benign 726,750(+) GCCGT(A/G)GCGGC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs878855038 Uncertain significance 727,160(+) TGTGC(A/G)GCTGC intron-variant, nc-transcript-variant, reference, missense
rs878855039 Uncertain significance 727,270(+) TGCGC(A/C)GCGAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRKAR1B Gene

Variant ID Type Subtype PubMed ID
dgv11108n54 CNV loss 21841781
dgv11109n54 CNV gain 21841781
dgv11110n54 CNV loss 21841781
dgv1177e199 CNV deletion 23128226
dgv3731e59 CNV duplication 20981092
esv1089300 CNV deletion 17803354
esv1167523 CNV deletion 17803354
esv1339677 CNV insertion 17803354
esv1611886 CNV deletion 17803354
esv1697450 CNV deletion 17803354
esv23027 CNV loss 19812545
esv23727 CNV loss 19812545
esv25048 CNV gain 19812545
esv25246 CNV loss 19812545
esv2661211 CNV deletion 23128226
esv2667360 CNV deletion 23128226
esv2673044 CNV deletion 23128226
esv2733626 CNV deletion 23290073
esv2733627 CNV deletion 23290073
esv2733629 CNV deletion 23290073
esv2733630 CNV deletion 23290073
esv2733631 CNV deletion 23290073
esv2733632 CNV deletion 23290073
esv2733633 CNV deletion 23290073
esv2733634 CNV deletion 23290073
esv2733635 CNV deletion 23290073
esv2733636 CNV deletion 23290073
esv2733637 CNV deletion 23290073
esv2733638 CNV deletion 23290073
esv2733640 CNV deletion 23290073
esv2733641 CNV deletion 23290073
esv2733642 CNV deletion 23290073
esv2733643 CNV deletion 23290073
esv2733644 CNV deletion 23290073
esv2733645 CNV deletion 23290073
esv2733646 CNV deletion 23290073
esv2733647 CNV deletion 23290073
esv2733648 CNV deletion 23290073
esv2733649 CNV deletion 23290073
esv2733651 CNV deletion 23290073
esv2733652 CNV deletion 23290073
esv2733653 CNV deletion 23290073
esv2859902 CNV duplication 24192839
esv3069 CNV loss 18987735
esv3540996 CNV deletion 23714750
esv3611782 CNV loss 21293372
esv3611783 CNV loss 21293372
esv3611784 CNV loss 21293372
esv998846 CNV gain 20482838
nsv1021075 CNV gain 25217958
nsv1073622 CNV deletion 25765185
nsv1074051 CNV deletion 25765185
nsv1074052 CNV deletion 25765185
nsv1074990 CNV deletion 25765185
nsv1078007 CNV duplication 25765185
nsv1078576 CNV duplication 25765185
nsv1120540 CNV tandem duplication 24896259
nsv1120541 CNV tandem duplication 24896259
nsv1129776 CNV tandem duplication 24896259
nsv1133642 CNV deletion 24896259
nsv1135974 CNV deletion 24896259
nsv1137569 CNV deletion 24896259
nsv1145117 CNV deletion 24896259
nsv1148788 CNV insertion 26484159
nsv605688 CNV loss 21841781
nsv605693 CNV gain+loss 21841781
nsv950782 CNV deletion 24416366
nsv950783 CNV deletion 24416366

Variation tolerance for PRKAR1B Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKAR1B Gene

Human Gene Mutation Database (HGMD)
PRKAR1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKAR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAR1B Gene

Disorders for PRKAR1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKAR1B Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
prkar1b-related neurodegenerative dementia with intermediate filaments
carney complex variant
  • carney complex
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRKAR1B

Genetic Association Database (GAD)
PRKAR1B
Human Genome Epidemiology (HuGE) Navigator
PRKAR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKAR1B
genes like me logo Genes that share disorders with PRKAR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAR1B Gene

Publications for PRKAR1B Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 22 64
  2. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. (PMID: 7925653) Solberg R. … Taylor S.S. (Exp. Cell Res. 1994) 3 4 64
  4. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PMID: 1358799) Solberg R. … de la Chapelle A. (Genomics 1992) 2 3 64
  5. Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. (PMID: 1708242) Solberg R. … Jahnsen T. (Biochem. Biophys. Res. Commun. 1991) 3 4 64

Products for PRKAR1B Gene

Sources for PRKAR1B Gene

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