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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKAR1B Gene

protein-coding   GIFtS: 67
GCID: GC07M000588

Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta1 2
PRKAR12
CAMP-Dependent Protein Kinase Type I-Beta Regulatory Subunit2

External Ids:    HGNC: 93901   Entrez Gene: 55752   Ensembl: ENSG000001881917   OMIM: 1769115   UniProtKB: P313213   

Export aliases for PRKAR1B gene to outside databases

Previous GC identifers: GC07U990076 GC17P067105 GC07M000491 GC07M000555 GC07M000507


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKAR1B Gene:
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second
messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell
including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2
regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.(supplied
by OMIM, Jun 2009)

GeneCards Summary for PRKAR1B Gene: 
PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta) is a protein-coding gene. Diseases associated with PRKAR1B include familial atrial fibrillation, and bloom syndrome, and among its related super-pathways are PKA activation in glucagon signalling and Regulation of Water Balance by Renal Aquaporins. GO annotations related to this gene include cAMP binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR2A.

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

summary for PRKAR1B Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKAR1B gene promoter:
         Pax-5   Egr-1   HSF1 (long)   Egr-4   Arnt   CREB   deltaCREB   HSF1short   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRKAR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKAR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

PRKAR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR1B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000588:  view genomic region     (about GC identifiers)

Start:
588,834 bp from pter      End:
767,313 bp from pter
Size:
178,480 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 650,549-825,534     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type I-beta regulatory subunit  
Size: 381 amino acids; 43073 Da
Subunit: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP
releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this
cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma
membrane
Subcellular location: Cell membrane
2 PDB 3D structures from and Proteopedia for PRKAR1B:
4DIN (3D)        4F9K (3D)    
Secondary accessions: Q8N422

Explore the universe of human proteins at neXtProt for PRKAR1B: NX_P31321

Explore proteomics data for PRKAR1B at MOPED 

Post-translational modifications:

  • UniProtKB: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the
    inhibition of its activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31321

  • PRKAR1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKAR1B Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001158230.1  NP_001158231.1  NP_001158232.1  NP_001158233.1  NP_001158234.1  NP_002726.1  

    ENSEMBL proteins: 
     ENSP00000385749   ENSP00000385349   ENSP00000353415   ENSP00000383569   ENSP00000402648  
     ENSP00000394633   ENSP00000406670   ENSP00000410414   ENSP00000440449   ENSP00000444487  
    Reactome Protein details: P31321
    Human Recombinant Protein Products for PRKAR1B: 
    EMD Millipore Purified and/or Recombinant PRKAR1B Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PRKAR1B
    OriGene Protein Over-expression Lysate for PRKAR1B
    OriGene MassSpec for PRKAR1B 
    OriGene Custom Protein Services for PRKAR1B
    GenScript Custom Purified and Recombinant Proteins Services for PRKAR1B
    Novus Biologicals PRKAR1B Protein
    Novus Biologicals PRKAR1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005952cAMP-dependent protein kinase complex NAS1708242

    PRKAR1B for ontologies           About GeneDecksing



    PRKAR1B Antibody Products: 
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    ThermoFisher Antibodies for PRKAR1B
    LSBio Antibodies in human, mouse, rat for PRKAR1B 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, regulatory, type I, beta subunit 
    Protein kinase A
    Protein kinase A (PKA) family

    5/7 InterPro protein domains (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P31321

    ProtoNet protein and cluster: P31321

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    PRKAR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAP1_HUMAN, P31321
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

         Genatlas biochemistry entry for PRKAR1B:
    protein kinase,cAMP-dependent,type I,beta subunit,regulatory polypeptide

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity IDA--
    GO:0008603cAMP-dependent protein kinase regulator activity NAS1708242
    GO:0030552cAMP binding IEA--
    GO:0034236protein kinase A catalytic subunit binding IPI--
         
    PRKAR1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRKAR1B:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prkar1b):
     behavior/neurological  immune system  integument  nervous system 

    PRKAR1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkar1btm1Gsm for PRKAR1B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKAR1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKAR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAR1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKAR1B 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAR1B:
    hsa-miR-92a hsa-miR-363 hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for PRKAR1B
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PRKAR1B

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): PRKAR1B (NM_002735)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAR1B
    Sirion Biotech Customized lentivirus for stable overexpression of PRKAR1B 
                         Customized lentivirus expression plasmids for stable overexpression of PRKAR1B 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKAR1B About   (see all 63)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    Glucagon signaling in metabolic regulation0.69
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    414-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37
    5Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Insulin signaling pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/26 EMD Millipore Pathways for PRKAR1B (see all 26)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Transcription PPAR Pathway

    5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAR1B (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for PRKAR1B
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/32 GeneGo (Thomson Reuters) Pathways for PRKAR1B (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/6 BioSystems Pathways for PRKAR1B (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    TGF-beta Receptor Signaling Pathway

    5/42        Reactome Pathways for PRKAR1B (see all 42)
        PKA activation
    Signaling by EGFR in Cancer
    DARPP-32 events
    Downstream signal transduction
    Signal Transduction


    2         Kegg Pathways  (Kegg details for PRKAR1B):
        Apoptosis
    Insulin signaling pathway


    PRKAR1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKAR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for PRKAR1B (P313212, 3 ENSP000003534154) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106443, ENSP000003514104I2D: score=3 STRING: ENSP00000351410
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    AKAP1Q926673, ENSP000003377364I2D: score=3 STRING: ENSP00000337736
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ----
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation NAS1708242
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--

    PRKAR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PRKAR1B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PRKAR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    1 HMDB Compound for PRKAR1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about PRKAR1B / KAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKAR1B gene (6 alternative transcripts): 
    NM_001164758.1  NM_001164759.1  NM_001164760.1  NM_001164761.1  NM_001164762.1  NM_002735.2  

    Unigene Cluster for PRKAR1B:

    Protein kinase, cAMP-dependent, regulatory, type I, beta
    Hs.520851  [show with all ESTs]
    Unigene Representative Sequence: NM_001164761
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406797(uc003siv.3) ENST00000403562 ENST00000360274 ENST00000400758(uc003six.1)
    ENST00000430040 ENST00000414568 ENST00000417852 ENST00000456696 ENST00000488474
    ENST00000478198 ENST00000537384(uc021zyj.1) ENST00000544935(uc003siu.2 uc021zyi.1 uc021zyk.1 uc003siw.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAR1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAR1B

    Additional mRNA sequence: 

    AK098822.1 AK124153.1 AK289464.1 AK297337.1 AK315951.1 AK315990.1 AL833563.1 BC013368.2 
    BC026734.1 BC036828.1 BC070478.1 M65066.1 

    23 DOTS entries:

    DT.86842826  DT.100028667  DT.449530  DT.100882718  DT.100785149  DT.97854140  DT.92427825  DT.95372126 
    DT.97854138  DT.422588  DT.121111468  DT.101969024  DT.121111513  DT.91893720  DT.95100163  DT.100882710 
    DT.121111381  DT.121111459  DT.121111484  DT.40127267  DT.75115664  DT.97807535  DT.95372130 

    24/83 AceView cDNA sequences (see all 83):

    BM924084 BX459980 AL047457 BX395406 BX442296 BX422448 BX428117 BX374447 
    BX440329 BI598242 BQ637910 BM545135 BQ067119 AL711491 BQ882361 BM927320 
    AW732869 BM800464 BX461088 BX385235 BX401114 AU117287 BX376816 AW160661 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKAR1B expression in normal human tissues (normalized intensities)      PRKAR1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCATTAAA
    PRKAR1B Expression
    About this image


    PRKAR1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Subthalamic Nucleus   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             autonomic/sympathetic/ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   

    See PRKAR1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKAR1B

    SOURCE GeneReport for Unigene cluster: Hs.520851

    UniProtKB/Swiss-Prot: KAP1_HUMAN, P31321
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their
    expression varies among tissues and is in some cases constitutive and in others inducible

        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAR1B: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR1B gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkar1b1 , 5 protein kinase, cAMP dependent regulatory, type I beta1, 5 85.91(n)1
    94.75(a)1
      5 (77.74 cM)5
    190851  NM_001253890.11  NP_001240819.11 
     1390173065 
    chicken
    (Gallus gallus)
    Aves PRKAR1B1 protein kinase, cAMP-dependent, regulatory, type I, more 80.49(n)
    93.18(a)
      416446  XM_414754.3  XP_414754.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAR1B6
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343385.1(577728-634758)
    zebrafish
    (Danio rerio)
    Actinopterygii prkar1b1 protein kinase, cAMP-dependent, regulatory, type I, more 82.44(n)
    94.62(a)
      767685  NM_001076623.1  NP_001070091.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-R16
    cAMP-dependent protein kinase R1
    54(a)
    1 → many
    3L(20809218-20829148)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-21 Protein KIN-2 58.96(n)
    59.61(a)
      180864  NM_001083302.1  NP_001076771.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCY16
    Regulatory subunit of the cyclic AMP-dependent pro...
    28(a)
    1 → many
    IX(290419-291669)


    ENSEMBL Gene Tree for PRKAR1B (if available)
    TreeFam Gene Tree for PRKAR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKAR1B gene
    PRKAR2A2  PRKAR2B2  PRKAR1A2  
    9 SIMAP similar genes for PRKAR1B using alignment to 7 protein entries:     KAP1_HUMAN (see all proteins):
    RET/PTC2    DKFZp779L0468    PRKAR1A    PRKAR1A/RARA fusion    PRKAR2A    PRKG1
    PRKAR2B    PRKG2    WUGSC

    PRKAR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4876 SNPs in PRKAR1B are shown (see all 4876)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93303991,2
    C,F--588334(+) ACAGTG/ACAGAG 6 -- ds50014Minor allele frequency- A:0.38NA CSA 8
    rs1412430271,2
    --588354(+) TGGGCA/CCCGTC 6 -- ds50010--------
    rs1455664591,2
    --588357(+) GCCCCA/GTCTAC 6 -- ds50010--------
    rs93304001,2
    C,F--588423(+) GCTCAA/TATGAG 6 -- ds50018Minor allele frequency- T:0.23NA WA CSA 13
    rs1883116251,2
    --588434(+) AACGTC/TTGGAT 6 -- ds50010--------
    rs1932808411,2
    --588478(+) GACAAC/TGCTCA 6 -- ds50010--------
    rs1419904261,2
    --588504(+) ATACAC/TAGGGC 6 -- ds50010--------
    rs1463013021,2
    C--588584(+) GTGGAC/TGGGTG 6 -- ds50010--------
    rs1854440561,2
    --588617(+) GCTGTC/TGTTTA 6 -- ds50010--------
    rs1393230531,2
    C--588651(+) GAAGAA/TGAAAG 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRKAR1B (588834 - 767313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/47 variations for PRKAR1B (see all 47):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667360CNV Deletion23128226
    esv2733652CNV Deletion23290073
    esv2733647CNV Deletion23290073
    esv2733631CNV Deletion23290073
    esv2733646CNV Deletion23290073
    esv3069CNV Deletion18987735
    esv2733626CNV Deletion23290073
    esv2733634CNV Deletion23290073
    esv1697450CNV Deletion17803354
    esv2733645CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176911    OMIM disorders: --

    14 diseases for PRKAR1B:    About MalaCards
    familial atrial fibrillation    bloom syndrome    dengue hemorrhagic fever    neurologic diseases
    hemorrhagic fever    hiv type 1    pituitary adenoma    adenoma
    systemic lupus erythematosus    lupus erythematosus    colorectal cancer    endotheliitis
    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PRKAR1B:
    Familial atrial fibrillation

    PRKAR1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKAR1B
    Human Genome Epidemiology (HuGE) Navigator: PRKAR1B (2 documents)

    Export disorders for PRKAR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKAR1B gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with PRKAR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    2. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
    3. Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. (PubMed id 7925653)1, 2 Solberg R.... Taylor S.S. (1994)
    4. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PubMed id 1358799)1, 3 Solberg R....de la Chapelle A. (1992)
    5. Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. (PubMed id 1708242)1, 2 Solberg R.... Jahnsen T. (1991)
    6. Exclusion of catalytic and regulatory subunits of cAM P-dependent protein kinase as candidate genes for the defect causing cystic fib rosis. (PubMed id 3479018)1, 3 Scambler P....Jahnsen T. (1987)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. (PubMed id 23115245)2 Burgers P.P.... Heck A.J. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5575 HGNC: 9390 AceView: PRKAR1B Ensembl:ENSG00000188191 euGenes: HUgn5575
    ECgene: PRKAR1B Kegg: 5575 H-InvDB: PRKAR1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKAR1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAR1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKAR1B gene:
    Search GeneIP for patents involving PRKAR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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