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Aliases for PRKAR1B Gene

Aliases for PRKAR1B Gene

  • Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta 2 3
  • Protein Kinase, CAMP-Dependent, Regulatory Subunit Type I Beta 2 3 5
  • Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta 2 3
  • PRKAR1 3

External Ids for PRKAR1B Gene

Previous GeneCards Identifiers for PRKAR1B Gene

  • GC07U990076
  • GC17P067105
  • GC07M000491
  • GC07M000555
  • GC07M000507

Summaries for PRKAR1B Gene

Entrez Gene Summary for PRKAR1B Gene

  • The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for PRKAR1B Gene

PRKAR1B (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta) is a Protein Coding gene. Diseases associated with PRKAR1B include prkar1b-related neurodegenerative dementia with intermediate filaments and carney complex variant. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include cAMP binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR2B.

UniProtKB/Swiss-Prot for PRKAR1B Gene

  • Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Tocris Summary for PRKAR1B Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKAR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAR1B Gene

Genomics for PRKAR1B Gene

Regulatory Elements for PRKAR1B Gene

Promoters for PRKAR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKAR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKAR1B Gene

Chromosome:
7
Start:
549,196 bp from pter
End:
727,676 bp from pter
Size:
178,481 bases
Orientation:
Minus strand

Genomic View for PRKAR1B Gene

Genes around PRKAR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAR1B Gene

Proteins for PRKAR1B Gene

  • Protein details for PRKAR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31321-KAP1_HUMAN
    Recommended name:
    cAMP-dependent protein kinase type I-beta regulatory subunit
    Protein Accession:
    P31321
    Secondary Accessions:
    • Q8N422

    Protein attributes for PRKAR1B Gene

    Size:
    381 amino acids
    Molecular mass:
    43073 Da
    Quaternary structure:
    • The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1B to the plasma membrane.

    Three dimensional structures from OCA and Proteopedia for PRKAR1B Gene

neXtProt entry for PRKAR1B Gene

Proteomics data for PRKAR1B Gene at MOPED

Post-translational modifications for PRKAR1B Gene

  • The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Ubiquitination at Lys 261
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PRKAR1B (PKA RI beta)
  • Cell Signaling Technology (CST) Antibodies for PRKAR1B (PKAR1B)

No data available for DME Specific Peptides for PRKAR1B Gene

Domains & Families for PRKAR1B Gene

Suggested Antigen Peptide Sequences for PRKAR1B Gene

Graphical View of Domain Structure for InterPro Entry

P31321

UniProtKB/Swiss-Prot:

KAP1_HUMAN :
  • Contains 2 cyclic nucleotide-binding domains.
  • Belongs to the cAMP-dependent kinase regulatory chain family.
Domain:
  • Contains 2 cyclic nucleotide-binding domains.
Family:
  • Belongs to the cAMP-dependent kinase regulatory chain family.
genes like me logo Genes that share domains with PRKAR1B: view

Function for PRKAR1B Gene

Molecular function for PRKAR1B Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,type I,beta subunit,regulatory polypeptide
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
genes like me logo Genes that share phenotypes with PRKAR1B: view

Animal Models for PRKAR1B Gene

MGI Knock Outs for PRKAR1B:

Animal Model Products

miRNA for PRKAR1B Gene

miRTarBase miRNAs that target PRKAR1B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAR1B Gene

Localization for PRKAR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAR1B Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAR1B Gene COMPARTMENTS Subcellular localization image for PRKAR1B gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRKAR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0097546 ciliary base TAS --
genes like me logo Genes that share ontologies with PRKAR1B: view

Pathways & Interactions for PRKAR1B Gene

SuperPathways for PRKAR1B Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Aquaporin-mediated transport
4 G-Beta Gamma Signaling
5 Sweet Taste Signaling
genes like me logo Genes that share pathways with PRKAR1B: view

Gene Ontology (GO) - Biological Process for PRKAR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006468 protein phosphorylation NAS 1708242
GO:0006833 water transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PRKAR1B: view

No data available for SIGNOR curated interactions for PRKAR1B Gene

Drugs & Compounds for PRKAR1B Gene

(2) Drugs for PRKAR1B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
KT 5720 Pharma Positive, Allosteric regulator Selective protein kinase A inhibitor 0

(4) Additional Compounds for PRKAR1B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cAMP, sodium salt
76939-46-3
cAMPS-Rp, triethylammonium salt
151837-09-1
cAMPS-Sp, triethylammonium salt
93602-66-5
cGMP Dependent Kinase Inhibitor Peptide
82801-73-8

(5) Tocris Compounds for PRKAR1B Gene

Compound Action Cas Number
8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog 76939-46-3
cAMPS-Rp, triethylammonium salt cAMP antagonist 151837-09-1
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog 93602-66-5
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
KT 5720 Selective protein kinase A inhibitor 108068-98-0
genes like me logo Genes that share compounds with PRKAR1B: view

Transcripts for PRKAR1B Gene

Unigene Clusters for PRKAR1B Gene

Protein kinase, cAMP-dependent, regulatory, type I, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR1B Gene

No ASD Table

Relevant External Links for PRKAR1B Gene

GeneLoc Exon Structure for
PRKAR1B
ECgene alternative splicing isoforms for
PRKAR1B

Expression for PRKAR1B Gene

mRNA expression in normal human tissues for PRKAR1B Gene

mRNA differential expression in normal tissues according to GTEx for PRKAR1B Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Anterior cingulate cortex (BA24) (x5.4).

Protein differential expression in normal tissues from HIPED for PRKAR1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Heart (11.2), Fetal Brain (8.7), and Ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAR1B Gene



SOURCE GeneReport for Unigene cluster for PRKAR1B Gene Hs.520851

mRNA Expression by UniProt/SwissProt for PRKAR1B Gene

P31321-KAP1_HUMAN
Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
genes like me logo Genes that share expression patterns with PRKAR1B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PRKAR1B Gene

Orthologs for PRKAR1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKAR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKAR1B 35
  • 86.44 (n)
  • 91.6 (a)
PRKAR1B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAR1B 35
  • 87.62 (n)
  • 94.96 (a)
PRKAR1B 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkar1b 35
  • 85.91 (n)
  • 94.75 (a)
Prkar1b 16
Prkar1b 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkar1b 35
  • 84.52 (n)
  • 95.24 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKAR1B 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAR1B 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKAR1B 35
  • 80.49 (n)
  • 93.18 (a)
PRKAR1B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAR1B 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkar1b 35
  • 77.72 (n)
  • 93.8 (a)
zebrafish
(Danio rerio)
Actinopterygii prkar1b 35
  • 82.44 (n)
  • 94.62 (a)
prkar1b 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pka-R1 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-2 35
  • 58.96 (n)
  • 59.61 (a)
kin-2 36
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCY1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8266 36
  • 62 (a)
OneToMany
Species with no ortholog for PRKAR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAR1B Gene

ENSEMBL:
Gene Tree for PRKAR1B (if available)
TreeFam:
Gene Tree for PRKAR1B (if available)

Paralogs for PRKAR1B Gene

Paralogs for PRKAR1B Gene

genes like me logo Genes that share paralogs with PRKAR1B: view

Variants for PRKAR1B Gene

Sequence variations from dbSNP and Humsavar for PRKAR1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2763 -- 550,023(+) CAGAC(C/G)TCAAT utr-variant-3-prime
rs8382 -- 550,149(-) CTTCT(C/G)CTGGG utr-variant-3-prime
rs10620 -- 549,885(+) TGGGG(A/G)TGCGG utr-variant-3-prime
rs1126837 -- 549,429(-) TCACC(C/G/T)GATGT utr-variant-3-prime
rs1126844 -- 549,235(-) CTGCT(C/T)TGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRKAR1B Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
esv25048 CNV Gain 19812545
esv998846 CNV Gain 20482838
esv1089300 CNV Deletion 17803354
esv2733626 CNV Deletion 23290073
esv2733627 CNV Deletion 23290073
esv1697450 CNV Deletion 17803354
esv3069 CNV Deletion 18987735
esv2733629 CNV Deletion 23290073
esv2733630 CNV Deletion 23290073
esv2733631 CNV Deletion 23290073
esv2733632 CNV Deletion 23290073
esv2733633 CNV Deletion 23290073
esv2733634 CNV Deletion 23290073
esv1611886 CNV Deletion 17803354
esv2733635 CNV Deletion 23290073
esv2733636 CNV Deletion 23290073
esv2673044 CNV Deletion 23128226
nsv887129 CNV Loss 21882294
esv2733637 CNV Deletion 23290073
esv2733638 CNV Deletion 23290073
esv1339677 CNV Insertion 17803354
nsv887130 CNV Loss 21882294
nsv887131 CNV Loss 21882294
esv2733640 CNV Deletion 23290073
esv2733641 CNV Deletion 23290073
esv1167523 CNV Deletion 17803354
esv2733642 CNV Deletion 23290073
dgv7079n71 CNV Loss 21882294
esv23027 CNV Loss 19812545
esv2733643 CNV Deletion 23290073
dgv1177e199 CNV Deletion 23128226
esv25246 CNV Loss 19812545
esv23727 CNV Loss 19812545
esv2733644 CNV Deletion 23290073
esv2733645 CNV Deletion 23290073
esv2733646 CNV Deletion 23290073
esv2733647 CNV Deletion 23290073
esv2733648 CNV Deletion 23290073
esv2733649 CNV Deletion 23290073
esv2733651 CNV Deletion 23290073
esv2661211 CNV Deletion 23128226
esv2733652 CNV Deletion 23290073
esv2733653 CNV Deletion 23290073
esv2667360 CNV Deletion 23128226

Variation tolerance for PRKAR1B Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKAR1B Gene

HapMap Linkage Disequilibrium report
PRKAR1B
Human Gene Mutation Database (HGMD)
PRKAR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAR1B Gene

Disorders for PRKAR1B Gene

MalaCards: The human disease database

(12) MalaCards diseases for PRKAR1B Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
prkar1b-related neurodegenerative dementia with intermediate filaments
carney complex variant
  • carney complex, type 1
myxosarcoma
acrodysostosis
  • acrodysplasia
adrenal cortex disease
  • disorder of adrenal cortex
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRKAR1B

Genetic Association Database (GAD)
PRKAR1B
Human Genome Epidemiology (HuGE) Navigator
PRKAR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKAR1B
genes like me logo Genes that share disorders with PRKAR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAR1B Gene

Publications for PRKAR1B Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 23 67
  2. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PMID: 1358799) Solberg R. … de la Chapelle A. (Genomics 1992) 2 3
  3. Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis. (PMID: 3479018) Scambler P. … Jahnsen T. (Am. J. Hum. Genet. 1987) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all. (PMID: 24189052) Desimmie B.A. … Pathak V.K. (J. Mol. Biol. 2014) 3

Products for PRKAR1B Gene

Sources for PRKAR1B Gene

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