PRKAR1A Gene
protein-coding GIFtS: 70
GCID: GC17P066508
|
|
protein kinase, cAMP-dependent, regulatory, type I, alpha(Previous name: tissue specific extinguisher 1 )
(Previous symbols: PRKAR1, TSE1)
| |
Aliases
for PRKAR1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase, CAMP-Dependent, Regulatory, Type I, Alpha1 2 | | Tissue Specific Extinguisher 11 | | TSE11 2 3 5 | | ACRDYS12 | | PRKAR11 2 3 | | ADOHR2 | | Tissue-Specific Extinguisher 12 3 | | CNC2 | | PKR12 3 | | CAMP-Dependent Protein Kinase Regulatory Subunit RIalpha2 | | CAR2 5 | | CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Chain2 | | CNC12 5 | | CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit2 | | PPNAD12 5 | | Protein Kinase A Type 1a Regulatory Subunit2 |
Export aliases for PRKAR1A gene to outside databasesPrevious GC identifers: GC17P066304 GC17P069468 GC17P066972 GC17P067106 GC17P067107 GC17P064019 GC17P061893 |
Summaries
for PRKAR1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKAR1A:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. Theinactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes thedissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomericcatalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher thatdown-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene causeCarney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroidtumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been foundfor this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein forthe second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding twodifferent isoforms have been observed. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
 summary
for PRKAR1A: Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).
Gene Wiki entry for PRKAR1A
|
Genomic Views
for PRKAR1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKAR1A gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKAR1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAR1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23-q24 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q23-q24PRKAR1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P066508: view genomic region
(about GC identifiers)
Start:
|
66,409,764 bp from pter |
End:
|
66,547,460 bp from pter |
Size:
|
137,697 bases |
Orientation:
|
plus strand |
|
Proteins
for PRKAR1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644 (See
protein sequence)Recommended Name: cAMP-dependent protein kinase type I-alpha regulatory subunit Size: 381 amino acids; 42982 Da
Subunit: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMPreleases the two active catalytic monomers and the regulatory dimer. PRKAR1A also interacts with RFC2; the complex maybe involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in the presence ofcAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form of PJA2. Interactswith CBFA2T3 (By similarity). Interacts with PRKX; regulates this cAMP-dependent protein kinase. Interacts withC2orf88/smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with AICDA
Subcellular location: Cell membrane
Secondary accessions: Q567S7Explore the universe of human proteins at neXtProt for PRKAR1A: NX_P10644
Post-translational modifications:
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in theinhibition of its activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10644
PRKAR1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001263218.1 NP_001263219.1 NP_002725.1 NP_997636.1 NP_997637.1
ENSEMBL proteins: ENSP00000467057 ENSP00000465445 ENSP00000351410 ENSP00000464715 ENSP00000466722 ENSP00000464977 ENSP00000376474 ENSP00000445625 ENSP00000464701 ENSP00000467500 ENSP00000467311 ENSP00000466649 ENSP00000467867 ENSP00000466459 ENSP00000465013 ENSP00000468106 ENSP00000466314 ENSP00000465740 ENSP00000376475 Reactome Protein details: P10644
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
PRKAR1A for ontologies About GeneDecksing
PRKAR1A Antibody Products:
Assay Products for PRKAR1A: |
Protein
Domains /
Families
for PRKAR1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKAR1A for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P10644ProtoNet protein and cluster: P10644 3 Blocks protein families: IPB000595 Cyclic nucleotide-binding domain IPB002373 cAMP-dependent protein kinase signature IPB003117 cAMP-dependent protein kinase regulator
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644Similarity: Belongs to the cAMP-dependent kinase regulatory chain familySimilarity: Contains 2 cyclic nucleotide-binding domains |
Function
for PRKAR1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells Genatlas biochemistry entry for PRKAR1A:protein kinase,cAMP-dependent,regulatory,type I,alpha subunit,expressed at higher levels in pancreatic beta cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0008603 | cAMP-dependent protein kinase regulator activity |
IEA | -- | | GO:0030552 | cAMP binding |
IEA | -- | | GO:0031625 | ubiquitin protein ligase binding |
IDA | -- |
PRKAR1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRKAR1A:
Animal Models:
Mouse knock-outs for PRKAR1A: Prkar1atm1.1Lsk Prkar1atm1Gsm
15/20 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Prkar1a) (see all 20):
PRKAR1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRKAR1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/66 super-pathways (see all 66) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PKA activation in glucagon signalling | | | 3 | DAG and IP3 signaling | | | 4 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 5 | G Protein Signaling Pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/26 EMD Millipore Pathways for PRKAR1A (see all 26)
5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAR1A (see all 52)
2 
Cell Signaling Technology (CST) Pathways for PRKAR1A
5/32  GeneGo (Thomson Reuters) Pathways for PRKAR1A (see all 32)
5/6  BioSystems Pathways for PRKAR1A (see all 6)
5/42 
Reactome Pathways for PRKAR1A (see all 42)
2 
Kegg Pathways (Kegg details for PRKAR1A):
PRKAR1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKAR1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/147 Interacting proteins for PRKAR1A (P106441, 2, 3 ENSP000003514104) via UniProtKB, MINT, STRING, and/or I2D (see all 147)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| AKAP10 | O435722, 3, ENSP000002257374 | MINT-68409 I2D:
score=6 STRING: ENSP00000225737 | | PYCARD | Q9ULZ32, 3, ENSP000002474704 | MINT-68047 I2D:
score=5 STRING: ENSP00000247470 | | RFC2 | P352501, 3, ENSP000000550774 | EBI-476431,EBI-476409 I2D:
score=3 STRING: ENSP00000055077 | | SMAD2 | Q157962, 3, ENSP000002621604 | MINT-60922 I2D:
score=3 STRING: ENSP00000262160 | | PRKX | P518171, 3, ENSP000002628484 | EBI-476431,EBI-4302903 I2D:
score=2 STRING: ENSP00000262848 |
About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
PRKAR1A for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKAR1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PRKAR1A for compounds About GeneDecksing
Compounds for PRKAR1A available from Tocris Bioscience About this table
1 HMDB Compound for PRKAR1A About this table
3 DrugBank Compounds for PRKAR1A About this table
10/18 Novoseek chemical compound relationships for PRKAR1A gene (see all 18) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cpccoet |
60.9 |
3 |
10716234 (2) |
| cinacalcet |
58.7 |
6 |
14593085 (3), 16882283 (2) |
| calcium |
53.4 |
154 |
10907347 (5), 17852049 (4), 11089548 (3), 15697170 (3) (see all 57) |
| cyclic amp |
49.2 |
13 |
15604237 (1), 16767104 (1), 18223213 (1), 16192737 (1) (see all 8) |
| l-amino acid |
47.8 |
3 |
15579475 (2) |
| vitamin d |
23.4 |
9 |
19724293 (2), 10048455 (1), 19667166 (1), 12412775 (1) (see all 5) |
| neomycin |
20.9 |
6 |
15067332 (3), 11994364 (1) |
| dexamethasone |
15.9 |
1 |
12915689 (1) |
| cgmp |
10.9 |
1 |
7589570 (1) |
| glucose |
4.57 |
2 |
17003271 (1) |
Search CenterWatch for drugs/clinical trials and news about PRKAR1A / KAP0
|
Transcripts
for PRKAR1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKAR1A gene (5 alternative transcripts): NM_001276289.1 NM_001276290.1 NM_002734.4 NM_212471.2 NM_212472.2 Unigene Cluster for PRKAR1A: Protein kinase, cAMP-dependent, regulatory, type I, alpha Hs.280342 [show with all ESTs]Unigene Representative Sequence: CR74931118/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000590353 ENST00000589017 ENST00000358598(uc002jhg.3) ENST00000592194
ENST00000585427 ENST00000585608 ENST00000589228 ENST00000585460 ENST00000392710(uc002jhi.3 uc002jhk.3)
ENST00000536854(uc002jhj.3 uc002jhl.3) ENST00000588702 ENST00000589309
ENST00000585981 ENST00000589480 ENST00000585815 ENST00000586397 ENST00000588178
ENST00000588188
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PRKAR1A (NM_002734) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKAR1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAR1A |
Additional cDNA sequence: AK124586.1 AK312307.1 AL050038.1 AY007115.1 BC036285.1 BC093042.1 CR749311.1 M18468.1 M33336.1 Y07642.1 24/40 DOTS entries (see all 40): DT.302776 DT.95362712 DT.99927439 DT.99984295 DT.100877957 DT.102835354 DT.95362652 DT.100765770 DT.121011433 DT.100877954 DT.100769055 DT.92476611 DT.97855563 DT.95362649 DT.121011456 DT.92476610 DT.121011415 DT.70105281 DT.100877949 DT.40276143 DT.92476368 DT.100877943 DT.100877948 DT.121011402 24/908 AceView cDNA sequences (see all 908): AA721253 BG231866 CA868517 CA389288 AU118860 AA315051 BG200314 AA976582 CA413655 AI446693 BF438916 BI963024 BQ022222 BG055240 AA827091 BP348978 CD109010 AV718955 BX506740 BM672164 BE327987 BQ425949 AA313159 BQ892583
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR1A (see all 21) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | · | 2h | · | 2i | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRKAR1A
|
Expression
for PRKAR1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKAR1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGCTAATA
About this image
See PRKAR1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAR1A
SOURCE GeneReport for Unigene cluster: Hs.280342
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expressionvaries among tissues and is in some cases constitutive and in others inducible
SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAR1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAR1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKAR1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAR1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAR1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1A |
Orthologs
for PRKAR1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PRKAR1A gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PRKAR1A1 |
protein kinase, cAMP-dependent, regulatory, type I, more |
82.41(n)
92.65(a) |
|
417438 NM_001007845.1 NP_001007846.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PRKAR1A6 |
-- |
92(a) |
1 ↔ 1 |
GL343260.1(1702189-1718380) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.35022 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.85(n) |
|
CA793080.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570899492 |
-- |
75.21(n) |
|
57089949 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pka-R13 |
actin filament organization cAMP-dependent
protein more |
72(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
kin-26 |
cAMP-dependent protein kinase regulatory subunit |
57(a) |
1 → many |
X(5971660-5977819) |
ENSEMBL Gene Tree for PRKAR1A (if available)
TreeFam Gene Tree for PRKAR1A (if available) |
Paralogs
for PRKAR1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRKAR1A gene
- PRKAR1B2 PRKAR2A2 PRKAR2B2
8 SIMAP similar genes for PRKAR1A using alignment to 17 protein entries: KAP0_HUMAN (see all proteins):RET/PTC2 DKFZp779L0468 PRKAR1A/RARA fusion PRKAR1B PRKAR2B PRKAR2A
PRKG1 WUGSC
PRKAR1A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PRKAR1A
PGOHUM00000244795
|
Genomic Variants
for PRKAR1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKAR1A (66409764 - 66547460 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKAR1A: --
Human Gene Mutation Database (HGMD): PRKAR1A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAR1A |
|
Disorders
/ Diseases
for PRKAR1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKAR1A for disorders About GeneDecksing
OMIM gene information: 188830
OMIM disorders: 160980 255960 188550 610489
UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644
Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasiasyndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatousmelanotic schwannomas Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomalrecessive Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1)[MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causingACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmentedmicronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can alsobe observed in patients without other manifestations or familial history Defects in PRKAR1A are the cause of acrodysostosis type 1, with or without hormone resistance (ACRDYS1)[MIM:101800]. ACRDYS1 is a form of skeletal dysplasia characterized by short stature, severe brachydactyly, facialdysostosis, and nasal hypoplasia. Affected individuals often have advanced bone age and obesity. Laboratory studiesshow resistance to multiple hormones, including parathyroid, thyrotropin, calcitonin, growth hormone-releasinghormone, and gonadotropin. However, not all patients show endocrine abnormalities
20/79  diseases for PRKAR1A (see all 79): About MalaCardscarney complex central nervous system origin vertigo pigmented adrenocortical disease, primary, 1 peutz-jeghers syndrome
growth hormone secreting pituitary adenoma hypocalcemia, autosomal dominant pigmented adrenocortical disease primary pigmented nodular adrenocortical disease
multiple endocrine neoplasia thyroiditis adrenocortical tumor, somatic mccune albright syndrome
hypocalciuric hypercalcemia hypocalcemia myxoma common variable immunodeficiency
odontogenic myxoma parathyroid adenoma adrenal hyperplasia pituitary adenoma
9 diseases from the University of Copenhagen DISEASES database for PRKAR1A:Carney complex Acrodysostosis Cushing's syndrome McCune Albright syndrome
Wermer syndrome Adenoma Central nervous system origin vertigo Peutz-Jeghers syndrome
Pituitary adenoma 10/45 Novoseek disease relationships for PRKAR1A gene (see all 45) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hypocalcemia, autosomal dominant |
89.2 |
6 |
10835431 (1), 11089548 (1), 8783675 (1), 15005845 (1) (see all 5) |
| myxoma |
86 |
22 |
15982496 (4), 16001434 (4), 19494712 (3), 19293268 (2) (see all 8) |
| nshpt |
85.1 |
7 |
15579740 (2), 8878438 (1), 8783675 (1) |
| cushing syndrome |
82.2 |
11 |
16001332 (1), 16767104 (1), 16756677 (1), 19833579 (1) (see all 9) |
| lentigo |
81.9 |
2 |
20358582 (1), 19169494 (1) |
| adrenal hyperplasia |
81.2 |
1 |
18401830 (1) |
| multiple endocrine neoplasia |
78.4 |
4 |
16772351 (1), 17613552 (1), 12161540 (1), 17411461 (1) |
| adenoma adrenocortical |
78.1 |
4 |
16001332 (1), 16189167 (1), 16192737 (1), 15591278 (1) |
| adrenocortical cancer |
76.8 |
3 |
16001332 (1), 16189167 (1), 17280861 (1) |
| lentigines |
76.4 |
2 |
19833579 (1) |
GeneTests: PRKAR1A
Carney Complex
Human Genome Epidemiology (HuGE) Navigator: PRKAR1A (6 documents)
Export disorders for PRKAR1A gene to outside databases
|
Publications
for PRKAR1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKAR1A gene, integrated from 9 sources (see all 341):
(articles sorted by number of sources associating them with PRKAR1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. (PubMed id 12213893)1, 2, 9 Groussin L.... Bertherat J. (2002)
- In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. (PubMed id 18241045)1, 2, 9 Greene E.L....Stratakis C.A. (2008)
- Control of PKA stability and signalling by the RING ligase praja2. (PubMed id 21423175)1, 2 Lignitto L.... Feliciello A. (2011)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. (PubMed id 15655353)1, 2 Gupte R.S.... Lee M.Y. (2005)
- Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. (PubMed id 15371594)1, 2 Veugelers M....Basson C.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids. (PubMed id 8977401)1, 2 Solberg R.... Tasken K. (1997)
- Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. (PubMed id 1889088)1, 2 Jones K.W.... Fournier R.E. (1991)
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External Searches for PRKAR1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing PRKAR1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing PRKAR1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRKAR1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for PRKAR1A gene:
Search GeneIP for patents involving PRKAR1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRKAR1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
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| | |  | OriGene Antibodies for PRKAR1A | | OriGene shRNA RFP for PRKAR1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAR1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAR1A | | | OriGene Protein Over-expression Lysate for PRKAR1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRKAR1A | | OriGene 3'-UTR Clone for PRKAR1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAR1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRKAR1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | Antibodies & Assays for PRKAR1A (PKAR1A) |
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 | | | PRKAR1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1A |
|  |  |  | | | | ThermoFisher Antibodies for PRKAR1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAR1A |
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