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PRKAR1A Gene

protein-coding   GIFtS: 75
GCID: GC17P066508

Protein Kinase, CAMP-Dependent, Regulatory, Type I, Alpha

(Previous name: tissue specific extinguisher 1)
(Previous symbols: PRKAR1, TSE1)
  See PRKAR1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Regulatory, Type I, Alpha1 2     PPNAD12 5
TSE11 2 3 5     Tissue Specific Extinguisher 11
PRKAR11 2 3     ADOHR2
Carney Complex Type 11 2     CNC2
Tissue-Specific Extinguisher 12 3     CAMP-Dependent Protein Kinase Regulatory Subunit RIalpha2
PKR12 3     CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Chain2
ACRDYS12 5     CAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit2
CAR2 5     Protein Kinase A Type 1a Regulatory Subunit2
CNC12 5     

External Ids:    HGNC: 93881   Entrez Gene: 55732   Ensembl: ENSG000001089467   OMIM: 1888305   UniProtKB: P106443   

Export aliases for PRKAR1A gene to outside databases

Previous GC identifers: GC17P066304 GC17P069468 GC17P066972 GC17P067106 GC17P067107 GC17P064019 GC17P061893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKAR1A Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a
tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast
hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene
rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear
localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the
protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).
Several alternatively spliced transcript variants encoding two different isoforms have been observed. (provided
by RefSeq, Jan 2013)

GeneCards Summary for PRKAR1A Gene:
PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha) is a protein-coding gene. Diseases associated with PRKAR1A include atrial myxoma, familial, and carney complex. GO annotations related to this gene include cAMP binding and ubiquitin protein ligase binding. An important paralog of this gene is PRKAR1B.

UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

summary for PRKAR1A Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAR1A gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKAR1A promoter sequence
   Search Chromatin IP Primers for PRKAR1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

PRKAR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAR1A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P066508:  view genomic region     (about GC identifiers)

Start:
66,507,921 bp from pter      End:
66,547,460 bp from pter
Size:
39,540 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase type I-alpha regulatory subunit  
Size: 381 amino acids; 42982 Da
Subunit: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP
releases the two active catalytic monomers and the regulatory dimer. PRKAR1A also interacts with RFC2; the
complex may be involved in cell survival. Interacts with AKAP4. Interacts with RARA; the interaction occurs in
the presence of cAMP or FSH and regulates RARA transcriptional activity. Interacts with the phosphorylated form
of PJA2. Interacts with CBFA2T3 (By similarity). Interacts with PRKX; regulates this cAMP-dependent protein
kinase. Interacts with C2orf88/smAKAP; this interaction may target PRKAR1A to the plasma membrane. Interacts with
AICDA
Secondary accessions: Q567S7

Explore the universe of human proteins at neXtProt for PRKAR1A: NX_P10644

Explore proteomics data for PRKAR1A at MOPED

Post-translational modifications: 

  • The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the
    inhibition of its activity1
  • Ubiquitination2 at Lys24, Lys63, Lys92, Lys134, Lys222, Lys244, Lys252, Lys261, Lys349
  • Modification sites at PhosphoSitePlus

  • See PRKAR1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001263218.1  NP_001263219.1  NP_001265362.1  NP_002725.1  NP_997636.1  NP_997637.1  

    ENSEMBL proteins: 
     ENSP00000465445   ENSP00000351410   ENSP00000464715   ENSP00000466722   ENSP00000464977  
     ENSP00000376474   ENSP00000445625   ENSP00000464701   ENSP00000467500   ENSP00000467311  
     ENSP00000466649   ENSP00000467867   ENSP00000466459   ENSP00000465013   ENSP00000468106  
     ENSP00000466314   ENSP00000465740   ENSP00000376475  
    Reactome Protein details: P10644

    PRKAR1A Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for PRKAR1A
    Sino Biological Cell Lysate for PRKAR1A
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PRKAR1A (11 products) 

     
    antibodies-online peptides for PRKAR1A

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    antibodies-online antibodies for PRKAR1A (26 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, regulatory, type I, alpha subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 7):
     IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR012198 cAMP_dep_PK_reg_su

    Graphical View of Domain Structure for InterPro Entry P10644

    ProtoNet protein and cluster: P10644

    3 Blocks protein domains:
    IPB000595 Cyclic nucleotide-binding domain
    IPB002373 cAMP-dependent protein kinase signature
    IPB003117 cAMP-dependent protein kinase regulator


    UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644
    Similarity: Belongs to the cAMP-dependent kinase regulatory chain family
    Similarity: Contains 2 cyclic nucleotide-binding domains


    Find genes that share domains with PRKAR1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAP0_HUMAN, P10644
    Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

         Genatlas biochemistry entry for PRKAR1A:
    protein kinase,cAMP-dependent,regulatory,type I,alpha subunit,expressed at higher levels in pancreatic beta cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity IDA--
    GO:0005515protein binding IPI11414803
    GO:0008603cAMP-dependent protein kinase regulator activity IDA--
    GO:0030552cAMP binding IEA--
    GO:0031625ubiquitin protein ligase binding IDA--
         
    Find genes that share ontologies with PRKAR1A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKAR1A:
     Increased cell number in S and  Increased cilium length after  

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Prkar1a) (see all 20):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal  pigmentation 

    Find genes that share phenotypes with PRKAR1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRKAR1A: Prkar1atm1.1Lsk Prkar1atm1Gsm

       genOway: Develop your customized and physiologically relevant rodent model for PRKAR1A

    miRNA
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    miRTarBase miRNAs that target PRKAR1A:
    hsa-mir-25-3p (MIRT050285), hsa-mir-324-3p (MIRT042851), hsa-mir-215-5p (MIRT024953), hsa-mir-155-5p (MIRT020712), hsa-mir-204-5p (MIRT047010), hsa-mir-16-5p (MIRT031552), hsa-mir-1296-5p (MIRT036121), hsa-mir-192-5p (MIRT026380), hsa-mir-96-5p (MIRT048733)

    Block miRNA regulation of human, mouse, rat PRKAR1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKAR1A (see all 49):
    hsa-miR-1321 hsa-miR-429 hsa-miR-200a hsa-miR-30d hsa-miR-138-2* hsa-miR-192 hsa-miR-141 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidPRKAR1A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKAR1A

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    GenScript: all cDNA clones in your preferred vector (see all 3): PRKAR1A (NM_002734)
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    Addgene plasmids for PRKAR1A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAR1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KAP0_HUMAN, P10644: Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus3
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005952cAMP-dependent protein kinase complex IEA--
    GO:0031588AMP-activated protein kinase complex IDA--

    Find genes that share ontologies with PRKAR1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKAR1A About   (see all 62)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    4G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    5Apoptosis (KEGG)
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37


    Find genes that share SuperPaths with PRKAR1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAR1A (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for PRKAR1A
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for PRKAR1A (see all 32)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PRKAR1A (see all 6)
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    G Protein Signaling Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell


    Selected Reactome Pathways for PRKAR1A (see all 6)
        PKA activation
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    DARPP-32 events
    Factors involved in megakaryocyte development and platelet production
    Regulation of water balance by renal Aquaporins


    2 Kegg Pathways  (Kegg details for PRKAR1A):
        Apoptosis
    Insulin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAR1A: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAR1A (P106441, 2, 3 ENSP000003514104) via UniProtKB, MINT, STRING, and/or I2D (see all 208)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176121, 3, ENSP000003095914EBI-476431,EBI-476586 I2D: score=7 STRING: ENSP00000309591
    AKAP10O435722, 3, ENSP000002257374MINT-68409 I2D: score=6 STRING: ENSP00000225737
    PYCARDQ9ULZ32, 3, ENSP000002474704MINT-68047 I2D: score=5 STRING: ENSP00000247470
    RFC2P352501, 3, ENSP000000550774EBI-476431,EBI-476409 I2D: score=3 STRING: ENSP00000055077
    SMAD2Q157962, 3, ENSP000002621604MINT-60922 I2D: score=3 STRING: ENSP00000262160
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0001932regulation of protein phosphorylation ----
    GO:0006112energy reserve metabolic process TAS--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1832337
    GO:0006469negative regulation of protein kinase activity ----

    Find genes that share ontologies with PRKAR1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for PRKAR1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    1 HMDB Compound for PRKAR1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    3 DrugBank Compounds for PRKAR1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Adenosine Monophosphate3'-5'-cyclic adenosine monophosphate (see all 5)60-92-4target--17139284 17016423 10592235
    Cyclic Guanosine Monophosphate-- 7665-99-8target--17139284 17016423 10592235
    Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for PRKAR1A gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cpccoet 60.9 3 10716234 (2)
    cinacalcet 58.7 6 14593085 (3), 16882283 (2)
    calcium 53.4 154 10907347 (5), 17852049 (4), 11089548 (3), 15697170 (3) (see all 57)
    cyclic amp 49.2 13 15604237 (1), 16767104 (1), 18223213 (1), 16192737 (1) (see all 8)
    l-amino acid 47.8 3 15579475 (2)
    vitamin d 23.4 9 19724293 (2), 10048455 (1), 19667166 (1), 12412775 (1) (see all 5)
    neomycin 20.9 6 15067332 (3), 11994364 (1)
    dexamethasone 15.9 1 12915689 (1)
    cgmp 10.9 1 7589570 (1)
    glucose 4.57 2 17003271 (1)



    Find genes that share compounds with PRKAR1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKAR1A gene (6 alternative transcripts): 
    NM_001276289.1  NM_001276290.1  NM_001278433.1  NM_002734.4  NM_212471.2  NM_212472.2  

    Unigene Cluster for PRKAR1A:

    Protein kinase, cAMP-dependent, regulatory, type I, alpha
    Hs.280342  [show with all ESTs]
    Unigene Representative Sequence: NM_212471
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000589017 ENST00000358598(uc002jhg.3) ENST00000592194 ENST00000585427
    ENST00000585608 ENST00000589228 ENST00000585460 ENST00000392710(uc002jhi.3 uc002jhk.3)
    ENST00000536854(uc002jhj.3 uc002jhl.3) ENST00000588702 ENST00000589309
    ENST00000585981 ENST00000589480 ENST00000585815 ENST00000586397 ENST00000588178
    ENST00000588188 ENST00000592800
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    Selected qRT-PCR Assays for microRNAs that regulate PRKAR1A (see all 49):
    hsa-miR-1321 hsa-miR-429 hsa-miR-200a hsa-miR-30d hsa-miR-138-2* hsa-miR-192 hsa-miR-141 hsa-miR-30a
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    OriGene ORF clones in mouse, rat for PRKAR1A
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRKAR1A (NM_002734)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAR1A
    Addgene plasmids for PRKAR1A 
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      QuantiTect SYBR Green Assays in human, mouse, rat PRKAR1A
      QuantiFast Probe-based Assays in human, mouse, rat PRKAR1A

    Additional mRNA sequence: 

    AK124586.1 AK312307.1 AL050038.1 AY007115.1 BC036285.1 BC093042.1 CR749311.1 M18468.1 
    M33336.1 Y07642.1 

    Selected DOTS entries (see all 36):

    DT.302776  DT.95362712  DT.99927439  DT.99984295  DT.100877957  DT.102835354  DT.95362652  DT.100765770 
    DT.100877954  DT.121011433  DT.100769055  DT.92476611  DT.97855563  DT.121011456  DT.92476610  DT.121011415 
    DT.70105281  DT.100877949  DT.40276143  DT.92476368  DT.100877943  DT.100877948  DT.121011402  DT.121011503 

    Selected AceView cDNA sequences (see all 908):

    BQ425949 AI568542 BQ575197 AI348531 BQ892583 AA329900 CR615537 BM459581 
    CB529158 BF940164 AA918751 AA947448 BQ215698 CA413131 S54707 CB130262 
    AI354863 CR600338 BE327987 BF438916 AA782436 CA868517 BQ218831 H25945 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR1A (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^
    SP1:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                       
    SP2:                                                              -     -     -     -     -     -     -     -     -     -                                       
    SP3:                                                              -     -     -     -     -     -     -     -     -     -                       -               
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                             

    ExUns: 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                          -                             -                                               -                                       
    SP2:                          -                             -                                               -                                       
    SP3:                          -                             -                                               -                                       
    SP4:                          -                             -                                               -                                       
    SP5:                          -                             -                                                                                       


    ECgene alternative splicing isoforms for PRKAR1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRKAR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTAATA
    PRKAR1A Expression
    About this image


    PRKAR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    PRKAR1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAR1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.280342

    UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644
    Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their
    expression varies among tissues and is in some cases constitutive and in others inducible

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAR1A: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Circadian Rhythms in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKAR1A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkar1a1 , 5 protein kinase, cAMP dependent regulatory, type I, more1, 5 88.1(n)1
    96.85(a)1
      11 (72.33 cM)5
    190841  NM_021880.21  NP_068680.11 
     1096494055 
    chicken
    (Gallus gallus)
    Aves PRKAR1A1 protein kinase, cAMP-dependent, regulatory, type I, more 82.41(n)
    92.65(a)
      417438  NM_001007845.1  NP_001007846.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAR1A6
    protein kinase, cAMP-dependent, regulatory, type I...
    92(a)
    1 ↔ 1
    GL343260.1(1696461-1718380)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35022 Xenopus laevis transcribed sequence with moderate similarity more 80.85(n)    CA793080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570899492   -- 75.21(n)    57089949 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-R11 , 3 actin filament organization
    cAMP-dependent protein more3
    cAMP-dependent protein kinase R11
    72(a)3
    64.1(n)1
    74.45(a)1
      403051  NM_168875.41  NP_730573.21 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-26
    Protein KIN-2, isoform a (kin-2) mRNA, complete cd...
    57(a)
    1 → many
    X(5970677-5977854) WBGene00002190
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCY16
    Regulatory subunit of the cyclic AMP-dependent pro...
    28(a)
    1 → many
    IX(290419-291669) YIL033C


    ENSEMBL Gene Tree for PRKAR1A (if available)
    TreeFam Gene Tree for PRKAR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKAR1A gene
    PRKAR1B2  PRKAR2A2  PRKAR2B2  
    8 SIMAP similar genes for PRKAR1A using alignment to 16 protein entries:     KAP0_HUMAN (see all proteins):
    RET/PTC2    DKFZp779L0468    PRKAR1A/RARA fusion    PRKAR1B    PRKAR2B    PRKAR2A
    PRKG1    WUGSC

    Find genes that share paralogs with PRKAR1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRKAR1A
    PGOHUM00000244795


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKAR1A (see all 592)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0694614
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0694612 I T mis40--------
    VAR_0468974
    Carney complex 1 (CNC1)4--see VAR_0468972 D Y mis40--------
    VAR_0468994
    Carney complex 1 (CNC1)4--see VAR_0468992 G W mis40--------
    VAR_0694564
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0694562 A T mis40--------
    VAR_0694604
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0694602 G E mis40--------
    VAR_0468954
    Carney complex 1 (CNC1)4--see VAR_0468952 R C mis40--------
    VAR_0468944
    Carney complex 1 (CNC1)4--see VAR_0468942 S N mis40--------
    VAR_0682414
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0682412 Y H mis40--------
    VAR_0694594
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0694592 Q R mis40--------
    VAR_0694654
    Acrodysostosis 1, with or without hormone resistance (ACRDYS1)4--see VAR_0694652 Y C mis40--------

    HapMap Linkage Disequilibrium report for PRKAR1A (66507921 - 66547460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRKAR1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833524CNV Gain17160897
    nsv833523CNV Gain17160897

    Human Gene Mutation Database (HGMD): PRKAR1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKAR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKAR1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188830   
    OMIM disorders: 160980  255960  188550  610489  101800  
    UniProtKB/Swiss-Prot: KAP0_HUMAN, P10644
  • Carney complex 1 (CNC1) [MIM:160980]: CNC is a multiple neoplasia syndrome characterized by spotty skin
    pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Intracardiac myxoma (INTMYX) [MIM:255960]: Inheritance is autosomal recessive. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Primary pigmented nodular adrenocortical disease 1 (PPNAD1) [MIM:610489]: A rare bilateral adrenal defect
    causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small
    pigmented micronodules observed in the cortex. Clinical manifestations of Cushing syndrome include facial and
    truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. PPNAD1 is
    most often diagnosed in patients with Carney complex, a multiple neoplasia syndrome. However it can also be
    observed in patients without other manifestations. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Acrodysostosis 1, with or without hormone resistance (ACRDYS1) [MIM:101800]: A form of skeletal dysplasia
    characterized by short stature, severe brachydactyly, facial dysostosis, and nasal hypoplasia. Affected
    individuals often have advanced bone age and obesity. Laboratory studies show resistance to multiple hormones,
    including parathyroid, thyrotropin, calcitonin, growth hormone-releasing hormone, and gonadotropin. However, not
    all patients show endocrine abnormalities. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • Selected diseases for PRKAR1A (see all 26):    
    About MalaCards
    atrial myxoma, familial    carney complex    pigmented nodular adrenocortical disease, primary, 1    acrodysostosis 1, with or without hormone resistance
    adrenocortical tumor, somatic    thyroid carcinoma, papillary, somatic    acrodysostosis    central nervous system origin vertigo
    primary pigmented nodular adrenocortical disease    acrodysostosis 2, with or without hormone resistance    skin papilloma    hypocalcemia, autosomal dominant
    autoimmune hypoparathyroidism    familial isolated pituitary adenoma    cushing syndrome, acth-independent adrenal, somatic    hypoparathyroidism
    acute promyelocytic leukemia    mccune albright syndrome    odontogenic myxoma    peutz-jeghers syndrome

    9 diseases from the University of Copenhagen DISEASES database for PRKAR1A:
    Carney complex     Acrodysostosis     Cushing's syndrome     McCune Albright syndrome
    Wermer syndrome     Adenoma     Central nervous system origin vertigo     Peutz-Jeghers syndrome
    Pituitary adenoma

    Find genes that share disorders with PRKAR1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRKAR1A gene (see all 45)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 89.2 6 10835431 (1), 11089548 (1), 8783675 (1), 15005845 (1) (see all 5)
    myxoma 86 22 15982496 (4), 16001434 (4), 19494712 (3), 19293268 (2) (see all 8)
    nshpt 85.1 7 15579740 (2), 8878438 (1), 8783675 (1)
    cushing syndrome 82.2 11 16001332 (1), 16767104 (1), 16756677 (1), 19833579 (1) (see all 9)
    lentigo 81.9 2 20358582 (1), 19169494 (1)
    adrenal hyperplasia 81.2 1 18401830 (1)
    multiple endocrine neoplasia 78.4 4 16772351 (1), 17613552 (1), 12161540 (1), 17411461 (1)
    adenoma adrenocortical 78.1 4 16001332 (1), 16189167 (1), 16192737 (1), 15591278 (1)
    adrenocortical cancer 76.8 3 16001332 (1), 16189167 (1), 17280861 (1)
    lentigines 76.4 2 19833579 (1)

    GeneTests: PRKAR1A
    GeneReviews: PRKAR1A
    Genetic Association Database (GAD): PRKAR1A
    Human Genome Epidemiology (HuGE) Navigator: PRKAR1A (6 documents)

    Export disorders for PRKAR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKAR1A gene, integrated from 10 sources (see all 363):
    (articles sorted by number of sources associating them with PRKAR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes. (PubMed id 19293268)1, 4, 9 Bertherat J....Stratakis C.A. (J. Clin. Endocrinol. Metab. 2009)
    2. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. (PubMed id 12213893)1, 2, 9 Groussin L.... Bertherat J. (J. Clin. Endocrinol. Metab. 2002)
    3. In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. (PubMed id 18241045)1, 2, 9 Greene E.L....Stratakis C.A. (Hum. Mutat. 2008)
    4. Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes. (PubMed id 19429701)1, 4, 9 Bimpaki E.I....Stratakis C.A. (Eur. J. Endocrinol. 2009)
    5. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. (PubMed id 10973256)1, 3, 9 Kirschner L.S....Stratakis C.A. (Nat. Genet. 2000)
    6. PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance. (PubMed id 23043190)1, 2 Linglart A.... Silve C. (J. Clin. Endocrinol. Metab. 2012)
    7. Control of PKA stability and signalling by the RING ligase praja2. (PubMed id 21423175)1, 2 Lignitto L.... Feliciello A. (Nat. Cell Biol. 2011)
    8. Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance. (PubMed id 21651393)1, 2 Linglart A.... Silve C. (N. Engl. J. Med. 2011)
    9. The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes. (PubMed id 20507346)1, 4 Stratakis C.A....Beckers A. (Clin. Genet. 2010)
    10. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5573 HGNC: 9388 AceView: PRKAR1A Ensembl:ENSG00000108946 euGenes: HUgn5573
    ECgene: PRKAR1A Kegg: 5573 H-InvDB: PRKAR1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKAR1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAR1A Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PRKAR1A[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKAR1A gene:
    Search GeneIP for patents involving PRKAR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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