PRKAG3 Gene
protein-coding GIFtS: 60
GCID: GC02M219651
|
|
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
| |
Aliases
for PRKAG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase, AMP-Activated, Gamma 3 Non-Catalytic Subunit1 2 | | 5'-AMP-Activated Protein Kinase Subunit Gamma-32 | | AMPKG32 3 | | 5'-AMP-Activated Protein Kinase, Gamma-3 Subunit2 | | AMPK Gamma32 3 | | AMPK Gamma-3 Chain2 | | AMPK Subunit Gamma-32 3 | | |
Export aliases for PRKAG3 gene to outside databasesPrevious GC identifers: GC02M217702 GC02M218408 GC02M219889 GC02M219512 GC02M219395 GC02M211540 |
Summaries
for PRKAG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKAG3:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is aheterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an importantenergy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK isactivated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxybeta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid andcholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletalmuscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energymetabolism in skeletal muscle. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AAKG3_HUMAN, Q9UGI9Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation ofalpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation ofcatalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive
Gene Wiki entry for PRKAG3
|
Genomic Views
for PRKAG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKAG3 gene promoter:
AML1a Ik-2 Lmo2 MyoD LCR-F1 Roaz ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKAG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35PRKAG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M219651: view genomic region
(about GC identifiers)
Start:
|
219,687,106 bp from pter |
End:
|
219,696,809 bp from pter |
Size:
|
9,704 bases |
Orientation:
|
minus strand |
|
Proteins
for PRKAG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AAKG3_HUMAN, Q9UGI9 (See
protein sequence)Recommended Name: 5'-AMP-activated protein kinase subunit gamma-3 Size: 489 amino acids; 54258 Da
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gammanon-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2 (By similarity)
Secondary accessions: Q4QQG8 Q4V779 Q9NRL1Alternative splicing: 2 isoforms: Q9UGI9-1 Q9UGI9-2 Explore the universe of human proteins at neXtProt for PRKAG3: NX_Q9UGI9
Post-translational modifications:
Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatoryfeedback loop between ULK1 and AMPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGI9
PRKAG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059127.2
ENSEMBL proteins: ENSP00000233944 ENSP00000436068 ENSP00000419272 ENSP00000416100 ENSP00000397133 ENSP00000444536 ENSP00000375947 Reactome Protein details: Q9UGI9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- | | GO:0031588 | AMP-activated protein kinase complex |
IEA | -- |
PRKAG3 for ontologies About GeneDecksing
PRKAG3 Antibody Products:
Assay Products for PRKAG3: |
Protein
Domains /
Families
for PRKAG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKAG3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UGI9ProtoNet protein and cluster: Q9UGI9 1 Blocks protein family: IPB000644 CBS domain
UniProtKB/Swiss-Prot: AAKG3_HUMAN, Q9UGI9Domain: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK,except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstratesequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by theupstream activating kinase STK11/LKB1Domain: The CBS domains mediate binding to AMP, ADP and ATP. 2 sites bind either AMP or ATP, whereas a third sitecontains a tightly bound AMP that does not exchange. Under physiological conditions AMPK mainly exists in its inactiveform in complex with ATP, which is much more abundant than AMPSimilarity: Belongs to the 5'-AMP-activated protein kinase gamma subunit familySimilarity: Contains 4 CBS domains |
Function
for PRKAG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AAKG3_HUMAN, Q9UGI9Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation ofalpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation ofcatalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PRKAG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAG3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PRKAG3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PRKAG3:
Animal Models:
Mouse knock-out Prkag3tm1Sson for PRKAG3
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Prkag3):
PRKAG3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRKAG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_Leptin signaling via PI3K-dependent pathway | | | 3 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 4 | mTOR signalling | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PRKAG3
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAG3
1 
Cell Signaling Technology (CST) Pathway for PRKAG3
1  Tocris Bioscience Pathway for PRKAG3
1  GeneGo (Thomson Reuters) Pathway for PRKAG3
3  BioSystems Pathways for PRKAG3
5/16 
Reactome Pathways for PRKAG3 (see all 16)
1  PharmGKB Pathway for PRKAG3
3 
Kegg Pathways (Kegg details for PRKAG3):
PRKAG3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRKAG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for PRKAG3 (Q9UGI92, 3 ENSP000002339444) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
PRKAG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKAG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for PRKAG3
Search CenterWatch for drugs/clinical trials and news about PRKAG3 / AAKG3
|
Transcripts
for PRKAG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKAG3 gene: NM_017431.2 Unigene Cluster for PRKAG3: Protein kinase, AMP-activated, gamma 3 non-catalytic subunit Hs.591634 [show with all ESTs]Unigene Representative Sequence: NM_0174318 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000233944 ENST00000529249 ENST00000470307 ENST00000490971(uc010fvy.1)
ENST00000430489 ENST00000439262(uc002vjb.1) ENST00000545803 ENST00000392098(uc010zkn.1 uc010zko.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRKAG3 (NM_017431) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKAG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAG3 |
Additional cDNA sequence: AJ249977.1 AK300078.1 AK300687.1 AK309865.1 BC098102.1 BC098255.1 BC098277.1 BC098306.1 1 DOTS entry: DT.408290 10 AceView cDNA sequences: NM_017431 AJ249977 CD628193 AA176339 AF214519 CD628195 AA256854 AA256383 W94830 AA178898
GeneLoc Exon Structure
|
Expression
for PRKAG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKAG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTAGATT
About this image
See PRKAG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAG3
SOURCE GeneReport for Unigene cluster: Hs.591634
UniProtKB/Swiss-Prot: AAKG3_HUMAN, Q9UGI9Tissue specificity: Skeletal muscle, with weak expression in heart and pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAG3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKAG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAG3 |
Orthologs
for PRKAG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRKAG3 gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PRKAG31 |
protein kinase, AMP-activated, gamma 3 non-catalytic more |
75.6(n)
75.71(a) |
|
424208 NM_001031258.2 NP_001026429.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PRKAG36 |
-- |
71(a) |
1 ↔ 1 |
1(95953569-95967311) |
African clawed frog
(Xenopus laevis) |
Amphibia |
prkag3-prov2 |
protein kinase, AMP-activated, gamma 3 non-catatlytic more |
73.86(n) |
|
BC043738.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1368501 |
zgc:136850 |
64.74(n)
67.95(a) |
|
678619 NM_001040366.1 NP_001035456.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
SNF4A&ggr;3 |
protein amino acid phosphorylation protein
serine/threonine more |
53(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y111B2A.83 |
-- |
49(a)
(best of 3) |
|
III(12610648-12616456) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SNF46 |
sucrose nonfermenting 4-like protein |
21(a) |
1 → many |
1(2899914-2904815) |
rice
(Oryza sativa) |
Liliopsida |
---- |
CBS domain containing membrane protein, putative, ...CBS domain containing membrane protein, putative, ... |
20(a)20(a) |
many ↔ manymany ↔ many |
4(19679007-19687088) 3(36117329-36124938) |
ENSEMBL Gene Tree for PRKAG3 (if available)
TreeFam Gene Tree for PRKAG3 (if available) |
Paralogs
for PRKAG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRKAG3 gene
- PRKAG12 PRKAG22
2 SIMAP similar genes for PRKAG3 using alignment to 5 protein entries: AAKG3_HUMAN (see all proteins):PRKAG2 PRKAG1
PRKAG3 for paralogs About GeneDecksing
|
Genomic Variants
for PRKAG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKAG3 (219687106 - 219696809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKAG3: --
Human Gene Mutation Database (HGMD): PRKAG3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAG3 |
|
Disorders
/ Diseases
for PRKAG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKAG3 for disorders About GeneDecksing
OMIM gene information: 604976
OMIM disorders: --
4  diseases for PRKAG3: About MalaCardspolycystic ovary syndrome cholesterol atherosclerosis schizophrenia
1 disease from the University of Copenhagen DISEASES database for PRKAG3:Wolff-Parkinson-White syndrome Human Genome Epidemiology (HuGE) Navigator: PRKAG3 (9 documents)
Export disorders for PRKAG3 gene to outside databases
|
Publications
for PRKAG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKAG3 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with PRKAG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. (PubMed id 10818001)1, 2, 3 Milan D....Andersson L. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. (PubMed id 10698692)1, 2 Cheung P.C.F.... Carling D. (2000)
- Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites. (PubMed id 17701023)1, 9 Weyrich P....Haring H.U. (2007)
- Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons. (PubMed id 14970697)1, 9 Amarger V....Andersson L. (2003)
- Gain-of-function R225W mutation in human AMPKgamma3 causing increased glycogen and decreased triglyceride in skeletal muscle. (PubMed id 17878938)1, 9 Costford S.R....Harper M.E. (2007)
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)2 Loffler A.S.... Stork B. (2011)
- HDAC1/NFI_B pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation. (PubMed id 21344388)1 Zhang H.S....Sang W.W. (2011)
- Common variants in 40 genes assessed for diabetes inc idence and response to metformin and lifestyle intervention in the diabetes pre vention program. (PubMed id 20682687)1 Jablonski K.A....Florez J.C. (2010)
- Naturally occurring R225W mutation of the gene encodi ng AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative c apacity and glucose uptake in human primary myotubes. (PubMed id 20473479)1 Crawford S.A....Harper M.E. (2010)
|
External Searches for PRKAG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRKAG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRKAG3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRKAG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRKAG3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRKAG3 gene:
Search GeneIP for patents involving PRKAG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRKAG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRKAG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAG3 | | | OriGene Protein Over-expression Lysate for PRKAG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRKAG3 | | OriGene 3'-UTR Clone for PRKAG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRKAG3 | | OriGene Custom Protein Services for PRKAG3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKAG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAG3 |
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| | Antibodies & Assays for PRKAG3 (AMPKG3) |
| | | | Search Tocris compounds for PRKAG3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAG3 |
|  |  |  | | | | ThermoFisher Antibodies for PRKAG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAG3 |
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