PRKAG1 Gene
protein-coding GIFtS: 64
GCID: GC12M049396
|
|
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
| |
Aliases
for PRKAG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase, AMP-Activated, Gamma 1 Non-Catalytic Subunit1 2 | | AMPKG2 | | AMPK Gamma12 3 | | AMPK Gamma-1 Chain2 | | 5'-AMP-Activated Protein Kinase Subunit Gamma-12 | | AMPKg3 | | 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit2 | | AMPK Subunit Gamma-13 |
Export aliases for PRKAG1 gene to outside databasesPrevious GC identifers: GC12P049402 GC12M049112 GC12M047682 GC12M046427 |
Summaries
for PRKAG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKAG1:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is aheterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an importantenergy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK isactivated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxybeta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid andcholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variantsencoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AAKG1_HUMAN, P54619Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation ofalpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation ofcatalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive
Gene Wiki entry for PRKAG1
|
Genomic Views
for PRKAG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKAG1 gene promoter:
E2F-3a E2F-4 E2F-5 HTF E2F-2 CREB HEN1 IRF-2 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKAG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q12-q14 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q12-q14PRKAG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M049396: view genomic region
(about GC identifiers)
Start:
|
49,396,055 bp from pter |
End:
|
49,412,980 bp from pter |
Size:
|
16,926 bases |
Orientation:
|
minus strand |
|
Proteins
for PRKAG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AAKG1_HUMAN, P54619 (See
protein sequence)Recommended Name: 5'-AMP-activated protein kinase subunit gamma-1 Size: 331 amino acids; 37579 Da
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gammanon-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2
4 PDB 3D structures from  and Proteopedia  for PRKAG1:2UV4 (3D)
2UV5 (3D)
2UV6 (3D)
2UV7 (3D)
Explore the universe of human proteins at neXtProt for PRKAG1: NX_P54619
Post-translational modifications:
Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of aregulatory feedback loop between ULK1, ULK2 and AMPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P54619
PRKAG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001193638.1 NP_001193639.1 NP_002724.1
ENSEMBL proteins: ENSP00000446987 ENSP00000448873 ENSP00000323867 ENSP00000447433 ENSP00000447637 ENSP00000447961 ENSP00000448972 ENSP00000449121 ENSP00000447671 ENSP00000450112 ENSP00000449637 ENSP00000448251 ENSP00000448739 ENSP00000449104 ENSP00000448290 ENSP00000450273 ENSP00000378599 Reactome Protein details: P54619
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
PRKAG1 for ontologies About GeneDecksing
PRKAG1 Antibody Products:
Assay Products for PRKAG1: |
Protein
Domains /
Families
for PRKAG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKAG1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P54619ProtoNet protein and cluster: P54619 1 Blocks protein family: IPB000644 CBS domain
UniProtKB/Swiss-Prot: AAKG1_HUMAN, P54619Domain: The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK,except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstratesequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by theupstream activating kinase STK11/LKB1Domain: The CBS domains mediate binding to AMP, ADP and ATP. 2 sites bind either AMP or ATP, whereas a third sitecontains a tightly bound AMP that does not exchange. Under physiological conditions AMPK mainly exists in its inactiveform in complex with ATP, which is much more abundant than AMPSimilarity: Belongs to the 5'-AMP-activated protein kinase gamma subunit familySimilarity: Contains 4 CBS domains |
Function
for PRKAG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AAKG1_HUMAN, P54619Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation ofalpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation ofcatalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive Genatlas biochemistry entry for PRKAG1:protein kinase,cAMP activated ,gamma 1 non catalytic subunit,complexing with alpha 2 and beta 2 subunits,involved infatty acid and cholesterol metabolism
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAG1 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
PRKAG1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PRKAG1:
Animal Models:
Mouse knock-out Prkag1tm1.2Mfor for PRKAG1
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Prkag1):
PRKAG1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRKAG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_Leptin signaling via PI3K-dependent pathway | | | 3 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 4 | mTOR signalling | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PRKAG1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAG1
1 
Cell Signaling Technology (CST) Pathway for PRKAG1
1  Tocris Bioscience Pathway for PRKAG1
3  GeneGo (Thomson Reuters) Pathways for PRKAG1
3  BioSystems Pathways for PRKAG1
5/16 
Reactome Pathways for PRKAG1 (see all 16)
1  PharmGKB Pathway for PRKAG1
3 
Kegg Pathways (Kegg details for PRKAG1):
PRKAG1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRKAG1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/876 Interacting proteins for PRKAG1 (P546191, 2, 3 ENSP000003238674) via UniProtKB, MINT, STRING, and/or I2D (see all 876)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
PRKAG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKAG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for PRKAG1
Search CenterWatch for drugs/clinical trials and news about PRKAG1 / AAKG1
|
Transcripts
for PRKAG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKAG1 gene (4 alternative transcripts): NM_001206709.1 NM_001206710.1 NM_002733.4 NM_212461.1 Unigene Cluster for PRKAG1: Protein kinase, AMP-activated, gamma 1 non-catalytic subunit Hs.530862 [show with all ESTs]Unigene Representative Sequence: NM_00120671018/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000548362 ENST00000547306 ENST00000316299 ENST00000548065(uc001rsz.3 uc001rsy.3)
ENST00000546531 ENST00000551259 ENST00000552212 ENST00000551770 ENST00000551696
ENST00000550125 ENST00000552793 ENST00000548950 ENST00000549726 ENST00000551121
ENST00000550448(uc010sme.2) ENST00000552463 ENST00000548857 ENST00000548605
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PRKAG1 (NM_002733) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKAG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAG1 |
Additional cDNA sequence: AK097606.1 AK293332.1 AK307994.1 BC000358.2 BT007345.1 15 DOTS entries: DT.100841368 DT.446289 DT.100709688 DT.100841373 DT.100841374 DT.121192235 DT.97792687 DT.95226733 DT.95208818 DT.95226719 DT.95226731 DT.95226737 DT.97860247 DT.91891359 DT.95226730 15 AceView cDNA sequences: CR613967 CR608916 NM_212461 BC000358 NM_002733 CR611774 CR604823 CR620523 CR590162 AK097606 CR596899 CR612109 CR616664 BT007345 U42412
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAG1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | |
| ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | - | | | | | | | |
ECgene alternative splicing isoforms for PRKAG1
|
Expression
for PRKAG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKAG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCACCAGG
About this image
See PRKAG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAG1
SOURCE GeneReport for Unigene cluster: Hs.530862
SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAG1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAG1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAG1 |
Orthologs
for PRKAG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRKAG1 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Prkag11 , 5 |
protein kinase, AMP-activated, gamma 1 non-catalytic more1, 5 |
87.67(n)1
97.55(a)1 |
|
15 (54.73 cM)5
190821 NM_016781.21 NP_058061.21
988127985 |
chicken
(Gallus gallus) |
Aves |
PRKAG11 |
protein kinase, AMP-activated, gamma 1 non-catalytic more |
77.94(n)
90.55(a) |
|
429688 NM_001034827.1 NP_001029999.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PRKAG16 |
-- |
86(a) |
1 ↔ 1 |
2(93963706-93974819) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.71232 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.46(n) |
|
BX845992.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa94d092 |
Danio rerio cDNA clone MGC63896 IMAGE6789945, complete more |
75.6(n) |
|
BC059181.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
SNF4A&ggr;3 |
protein amino acid phosphorylation protein
serine/threonine more |
63(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y111B2A.83
aakg-11 |
Protein AAKG-11 |
55(a)
(best of 3)3
56.74(n)1
55.02(a)1 |
|
III(12610648-12616456)3
1766771 NM_067236.31 NP_499637.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SNF46 |
sucrose nonfermenting 4-like protein |
20(a) |
1 → many |
1(2899914-2904815) |
rice
(Oryza sativa) |
Liliopsida |
---- |
CBS domain containing membrane protein, putative, ...CBS domain containing membrane protein, putative, ... |
20(a)19(a) |
many ↔ manymany ↔ many |
4(19679007-19687088) 3(36117329-36124938) |
ENSEMBL Gene Tree for PRKAG1 (if available)
TreeFam Gene Tree for PRKAG1 (if available) |
Paralogs
for PRKAG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRKAG1 gene
- PRKAG22 PRKAG32
3 SIMAP similar genes for PRKAG1 using alignment to 17 protein entries: AAKG1_HUMAN (see all proteins):PRKAG2 DKFZp781C1522 PRKAG3
PRKAG1 for paralogs About GeneDecksing
|
Genomic Variants
for PRKAG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKAG1 (49396055 - 49412980 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PRKAG1
2 CNVs: 86367 4777 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAG1 |
|
Disorders
/ Diseases
for PRKAG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKAG1 for disorders About GeneDecksing
OMIM gene information: 602742
OMIM disorders: --
11  diseases for PRKAG1: About MalaCardscholesterol ascariasis trichuriasis intrahepatic cholangiocarcinoma
neurologic diseases epididymitis cholangiocarcinoma atherosclerosis
hypoxia schizophrenia immunodeficiency
Human Genome Epidemiology (HuGE) Navigator: PRKAG1 (10 documents)
Export disorders for PRKAG1 gene to outside databases
|
Publications
for PRKAG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKAG1 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with PRKAG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. (PubMed id 8621499)1, 2, 3 Gao G....Witters L.A. (1996)
- Identification and characterization of a novel folliculin-interacting protein FNIP2. (PubMed id 18403135)1, 2 Hasumi H.... Schmidt L.S. (2008)
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)1, 2 Baba M....Zbar B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mammalian AMP-activated protein kinase subfamily. (PubMed id 8557660)1, 3 Stapleton D.... Kemp B.E. (1996)
- AMP-activated protein kinase phosphorylates cardiac tr oponin I and alters contractility of murine ventricular myocytes. (PubMed id 22456184)1 Oliveira S.M....Redwood C. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Sestrin2 modulates AMPK subunit expression and its res ponse to ionizing radiation in breast cancer cells. (PubMed id 22363791)1 Sanli T....Singh G. (2012)
- AMP-activated protein kinase regulation and biological actions in the heart. (PubMed id 22935535)1 Zaha V.G. and Young L.H. (2012)
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. (PubMed id 21892142)1 Mihaylova M.M. and Shaw R.J. (2011)
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External Searches for PRKAG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PRKAG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PRKAG1 gene
(According to HUGE)
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Specialized Databases showing PRKAG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for PRKAG1 gene:
Search GeneIP for patents involving PRKAG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PRKAG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PRKAG1 | | OriGene shRNA RFP for PRKAG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKAG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAG1 | | | OriGene Protein Over-expression Lysate for PRKAG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRKAG1 | | OriGene 3'-UTR Clone for PRKAG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRKAG1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRKAG1 | | OriGene Custom Protein Services for PRKAG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKAG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKAG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAG1 |
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| | Antibodies & Assays for PRKAG1 (AMPKG1) |
| | | | Search Tocris compounds for PRKAG1 |
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|  |  |  | | | | ThermoFisher Antibody for PRKAG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAG1 |
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