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Aliases for PRKAG1 Gene

Aliases for PRKAG1 Gene

  • Protein Kinase, AMP-Activated, Gamma 1 Non-Catalytic Subunit 2 3
  • AMPK Gamma1 3 4
  • AMPKG 3 4
  • 5-AMP-Activated Protein Kinase, Gamma-1 Subunit 3
  • 5-AMP-Activated Protein Kinase Subunit Gamma-1 3
  • AMPK Subunit Gamma-1 4
  • AMPK Gamma-1 Chain 3

External Ids for PRKAG1 Gene

Summaries for PRKAG1 Gene

Entrez Gene Summary for PRKAG1 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAG1 Gene

PRKAG1 (Protein Kinase, AMP-Activated, Gamma 1 Non-Catalytic Subunit) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein kinase binding and ADP binding. An important paralog of this gene is PRKAG3.

UniProtKB/Swiss-Prot for PRKAG1 Gene

  • AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gene Wiki entry for PRKAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAG1 Gene

Genomics for PRKAG1 Gene

Genomic Location for PRKAG1 Gene

Start:
49,002,272 bp from pter
End:
49,019,197 bp from pter
Size:
16,926 bases
Orientation:
Minus strand

Genomic View for PRKAG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAG1 Gene

Regulatory Elements for PRKAG1 Gene

Proteins for PRKAG1 Gene

  • Protein details for PRKAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54619-AAKG1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit gamma-1
    Protein Accession:
    P54619
    Secondary Accessions:
    • B4DDT7
    • Q8N7V9

    Protein attributes for PRKAG1 Gene

    Size:
    331 amino acids
    Molecular mass:
    37579 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.

    Three dimensional structures from OCA and Proteopedia for PRKAG1 Gene

    Alternative splice isoforms for PRKAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAG1 Gene

Proteomics data for PRKAG1 Gene at MOPED

Post-translational modifications for PRKAG1 Gene

  • Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys170 and Lys264

No data available for DME Specific Peptides for PRKAG1 Gene

Domains for PRKAG1 Gene

Protein Domains for PRKAG1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

AAKG1_HUMAN
Domain:
  • The AMPK pseudosubstrate motif resembles the sequence around sites phosphorylated on target proteins of AMPK, except the presence of a non-phosphorylatable residue in place of Ser. In the absence of AMP this pseudosubstrate sequence may bind to the active site groove on the alpha subunit (PRKAA1 or PRKAA2), preventing phosphorylation by the upstream activating kinase STK11/LKB1:
    • P54619
  • The CBS domains mediate binding to AMP, ADP and ATP. 2 sites bind either AMP or ATP, whereas a third site contains a tightly bound AMP that does not exchange. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP:
    • P54619
  • Contains 4 CBS domains.:
    • P54619
Family:
  • Belongs to the 5-AMP-activated protein kinase gamma subunit family.:
    • P54619
genes like me logo Genes that share domains with PRKAG1: view

Function for PRKAG1 Gene

Molecular function for PRKAG1 Gene

GENATLAS Biochemistry: protein kinase,cAMP activated ,gamma 1 non catalytic subunit,complexing with alpha 2 and beta 2 subunits,involved in fatty acid and cholesterol metabolism
UniProtKB/Swiss-Prot Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Gene Ontology (GO) - Molecular Function for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17028174
GO:0004679 contributes_to AMP-activated protein kinase activity ISS --
GO:0004691 cAMP-dependent protein kinase activity TAS 9598317
GO:0005515 protein binding IPI 16306228
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with PRKAG1: view
genes like me logo Genes that share phenotypes with PRKAG1: view

Animal Models for PRKAG1 Gene

MGI Knock Outs for PRKAG1:

miRNA for PRKAG1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKAG1 Gene

Localization for PRKAG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAG1 Gene COMPARTMENTS Subcellular localization image for PRKAG1 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0031588 AMP-activated protein kinase complex ISS --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with PRKAG1: view

Pathways for PRKAG1 Gene

genes like me logo Genes that share pathways with PRKAG1: view

Gene Ontology (GO) - Biological Process for PRKAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS 8663446
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IDA 17028174
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with PRKAG1: view

Transcripts for PRKAG1 Gene

mRNA/cDNA for PRKAG1 Gene

Unigene Clusters for PRKAG1 Gene

Protein kinase, AMP-activated, gamma 1 non-catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - - -
SP10: -
SP11: - - -
SP12: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PRKAG1 Gene

GeneLoc Exon Structure for
PRKAG1
ECgene alternative splicing isoforms for
PRKAG1

Expression for PRKAG1 Gene

mRNA expression in normal human tissues for PRKAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAG1 Gene

SOURCE GeneReport for Unigene cluster for PRKAG1 Gene Hs.530862

genes like me logo Genes that share expressions with PRKAG1: view

Orthologs for PRKAG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAG1 36
  • 99.8 (n)
  • 99.41 (a)
PRKAG1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAG1 36
  • 93.92 (n)
  • 98.78 (a)
PRKAG1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAG1 36
  • 94.02 (n)
  • 99.09 (a)
PRKAG1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkag1 36
  • 87.68 (n)
  • 97.58 (a)
Prkag1 16
Prkag1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAG1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAG1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkag1 36
  • 87.98 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves PRKAG1 36
  • 77.94 (n)
  • 90.55 (a)
PRKAG1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAG1 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7123 36
tropical clawed frog
(Silurana tropicalis)
Amphibia prkag2 36
  • 74.27 (n)
  • 86.97 (a)
Str.2067 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10524 36
zebrafish
(Danio rerio)
Actinopterygii prkag1 36
  • 73.29 (n)
  • 84.69 (a)
prkag1 37
  • 78 (a)
OneToOne
wufa94d09 36
fruit fly
(Drosophila melanogaster)
Insecta SNF4Agamma 37
  • 15 (a)
OneToMany
SNF4Agamma 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea aakg-1 36
  • 56.74 (n)
  • 55.02 (a)
aakg-1 37
  • 30 (a)
OneToMany
Y41G9A.3 38
  • 31 (a)
Y111B2A.8 38
  • 55 (a)
T20F7.6 38
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF4 37
  • 34 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os04g0401300 36
  • 42.46 (n)
  • 32.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7193 37
  • 49 (a)
OneToMany
Species with no ortholog for PRKAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAG1 Gene

ENSEMBL:
Gene Tree for PRKAG1 (if available)
TreeFam:
Gene Tree for PRKAG1 (if available)

Paralogs for PRKAG1 Gene

Paralogs for PRKAG1 Gene

genes like me logo Genes that share paralogs with PRKAG1: view

Variants for PRKAG1 Gene

Sequence variations from dbSNP and Humsavar for PRKAG1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941194 -- 49,012,280(-) TGCTG(C/G)CCAGT intron-variant
rs1042862 -- 49,002,553(-) TCCAT(C/T)TTGGC utr-variant-3-prime
rs1042868 -- 49,002,489(-) TATTC(A/C)CCTGT utr-variant-3-prime
rs1126930 - 49,005,349(+) CATCA(C/G)TGATT reference, missense
rs1138908 -- 49,008,516(-) GAGGA(C/G)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAG1 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897
esv2662608 CNV Deletion 23128226

Relevant External Links for PRKAG1 Gene

HapMap Linkage Disequilibrium report
PRKAG1

Disorders for PRKAG1 Gene

Relevant External Links for PRKAG1

Genetic Association Database (GAD)
PRKAG1
Human Genome Epidemiology (HuGE) Navigator
PRKAG1
genes like me logo Genes that share disorders with PRKAG1: view

No data available for UniProtKB/Swiss-Prot for PRKAG1 Gene

Publications for PRKAG1 Gene

  1. Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP- activated protein kinase. (PMID: 8621499) Gao G. … Witters L.A. (J. Biol. Chem. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PMID: 17028174) Baba M. … Zbar B. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4
  5. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PMID: 18403135) Hasumi H. … Schmidt L.S. (Gene 2008) 3 4

Products for PRKAG1 Gene

Sources for PRKAG1 Gene

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