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PRKACG Gene

protein-coding   GIFtS: 68
GCID: GC09M071627

Protein Kinase, CAMP-Dependent, Catalytic, Gamma

  See PRKACG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Catalytic, Gamma1 2     PKACg2
PKA C-Gamma2 3     CAMP-Dependent Protein Kinase Catalytic Subunit Gamma2
EC 2.7.11.113 8     Serine(Threonine) Protein Kinase2
KAPG2     EC 2.7.118

External Ids:    HGNC: 93821   Entrez Gene: 55682   Ensembl: ENSG000001650597   OMIM: 1768935   UniProtKB: P226123   

Export aliases for PRKACG gene to outside databases

Previous GC identifers: GC09M062671 GC09M063484 GC09M065197 GC09M067084 GC09M068857 GC09M070817


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKACG Gene:
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This
gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a
retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRKACG Gene:
PRKACG (protein kinase, cAMP-dependent, catalytic, gamma) is a protein-coding gene. Diseases associated with PRKACG include primary pigmented nodular adrenocortical disease. GO annotations related to this gene include cAMP-dependent protein kinase activity. An important paralog of this gene is PRKX.

UniProtKB/Swiss-Prot: KAPCG_HUMAN, P22612
Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus

summary for PRKACG Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKACG gene promoter:
         C/EBPbeta   ISGF-3   AP-1   FOXJ2 (long isoform)   ATF-2   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKACG promoter sequence
   Search Chromatin IP Primers for PRKACG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKACG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13   Ensembl cytogenetic band:  9q21.11   HGNC cytogenetic band: 9q13

PRKACG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKACG gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M071627:  view genomic region     (about GC identifiers)

Start:
71,627,445 bp from pter      End:
71,629,039 bp from pter
Size:
1,595 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KAPCG_HUMAN, P22612 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit gamma  
Size: 351 amino acids; 40434 Da
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of
the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the
inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic
subunits
Sequence caution: Sequence=AAC41690.1; Type=Erroneous initiation;
Secondary accessions: O60850 Q5VZ02 Q86YI1

Explore the universe of human proteins at neXtProt for PRKACG: NX_P22612

Explore proteomics data for PRKACG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys190
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKACG (P22612) (see all 12)
     TDFGFAK  LKPENLL  YLAPEII  RDLKPEN 


    See PRKACG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002723.2  
    ENSEMBL proteins: 
     ENSP00000366488  
    Reactome Protein details: P22612

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    Novus Biologicals PRKACG Proteins
    Novus Biologicals PRKACG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, catalytic, gamma subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P22612

    ProtoNet protein and cluster: P22612

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KAPCG_HUMAN, P22612
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRKACG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAPCG_HUMAN, P22612
    Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cAMP

         Genatlas biochemistry entry for PRKACG:
    protein kinase,cAMP-dependent,catalytic,gamma subunit,retroposon inserted inside the STM7 gene and transcribed in
    the opposite (antisense) strand specifically transcribed in primate testicular germ cells

         Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PRKACG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRKACG:
     Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKACG
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    Addgene plasmids for PRKACG 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PRKACG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKACG About   (see all 106)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    EGFR interacts with phospholipase C-gamma0.94
    Neurophysiological process PGE2 induced pain processing0.38
    PLC-gamma1 signalling0.94
    Signal transduction Calcium signaling0.35
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    4Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    5G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44


    Find genes that share SuperPaths with PRKACG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKACG (see all 53)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKACG (see all 39)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for PRKACG
        G Protein Signaling Pathways
    AMPK signaling
    Glucocorticoid receptor regulatory network
    Dopamine metabolism
    miRs in Muscle Cell Differentiation


    Selected Reactome Pathways for PRKACG (see all 14)
        PKA activation
    PKA-mediated phosphorylation of key metabolic factors
    CREB phosphorylation through the activation of Adenylate Cyclase
    Regulation of insulin secretion
    PKA activation in glucagon signalling

    1 PharmGKB Pathway for PRKACG
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PRKACG) (see all 49):
        MAPK signaling pathway
    Ras signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACG: 
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRKACG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKACG (P226123 ENSP000003664884) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYR2Q927363, ENSP000003555334I2D: score=1 STRING: ENSP00000355533
    TNP1P094303, ENSP000002369794I2D: score=1 STRING: ENSP00000236979
    TNP2Q059523, ENSP000003257384I2D: score=1 STRING: ENSP00000325738
    ABHD5ENSP000003908494STRING: ENSP00000390849
    ADCY1ENSP000002973234STRING: ENSP00000297323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with PRKACG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKACG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    3 HMDB Compounds for PRKACG    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for PRKACG gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 73 48 9600272 (2), 11972772 (2), 1826633 (2), 8089485 (2) (see all 37)
    threonine 55.3 1 8650259 (1)
    pkcs 50.9 2 8538623 (1), 8078925 (1)
    tyrosine 44.4 11 9819398 (1), 1828701 (1), 9120267 (1), 8389462 (1) (see all 10)
    phosphoenolpyruvate 43 1 1311681 (1)
    phosphatidylinositol 34.7 4 7612667 (3)
    glycogen 18.1 2 11579232 (1), 7980435 (1)
    manganese 14 1 7612667 (1)
    arginine 7.25 2 10390541 (1)
    hydroxyapatite 7.24 1 8346924 (1)



    Find genes that share compounds with PRKACG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRKACG gene: 
    NM_002732.3  

    Unigene Cluster for PRKACG:

    Protein kinase, cAMP-dependent, catalytic, gamma
    Hs.158029  [show with all ESTs]
    Unigene Representative Sequence: NM_002732
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377276(uc004agy.3)
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      QuantiFast Probe-based Assays in human, mouse, rat PRKACG

    Additional mRNA sequence: BC039888.1 

    1 DOTS entry:

    DT.210058 

    10 AceView cDNA sequences:

    BI827997 BC039888 BI830096 BG705102 NM_002732 M34182 AA861091 AW086441 
    AA912811 AI024862 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKACG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGTGGGC
    PRKACG Expression
    About this image


    PRKACG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PRKACG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKACG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158029

    UniProtKB/Swiss-Prot: KAPCG_HUMAN, P22612
    Tissue specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the
    content of transcript

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACG: 
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKACG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    Uncharacterized protein
    79(a)
    1 → many
    3(446210758-446225924)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    1 → many
    2(119457730-119468670)
    zebrafish
    (Danio rerio)
    Actinopterygii prkacaa1 protein kinase, cAMP-dependent, catalytic, alpha, genome more 76.35(n)
    81.48(a)
      564064  NM_001082840.1  NP_001076309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-C13 anterior/posterior pattern formation,
    imaginal more
    75(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F47F2.1b3   -- 49(a)
    (best of 2)
      X(3923777-3928330)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK31 TPK3 51.16(n)
    48.84(a)
      853688   NP_012755.1 
    rice
    (Oryza sativa)
    Liliopsida Os.328562 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.91(n)    AK102618.1 


    ENSEMBL Gene Tree for PRKACG (if available)
    TreeFam Gene Tree for PRKACG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKACG gene
    PRKX2  PRKG22  PRKACA2  PRKG12  PRKACB2  
    Selected SIMAP similar genes for PRKACG using alignment to 1 protein entry:     KAPCG_HUMAN(see all similar genes):
    KIN27    PRKACB    PRKACA    PRKX    PRKY    PRKG1
    RPS6KA3    RPS6KA1    RPS6KA2    RPS6KA6    AKT1    AKT3
    PRKG2    PRKCA    RPS6KA5    RPS6KB2    PRKCQ    PKN3

    Find genes that share paralogs with PRKACG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKACG (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115869981,2
    F--71627108(+) TTGGGG/AGACAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1855205811,2
    --71627137(+) TAGGGA/CAGCTG 1 -- ds50010--------
    rs412968441,2
    C,F--71627166(-) TCACCC/TTTGGG 1 -- ds50012Minor allele frequency- T:0.01NS 94
    rs111447621,2
    C,F,A,H--71627283(+) GTTCAT/CGGGGG 1 -- ds500123Minor allele frequency- C:0.20NS EA NA WA 2326
    rs412963421,2
    C,F--71627364(-) ACCTTA/CCCGTG 1 -- ds50018Minor allele frequency- C:0.16NS NA CSA WA EA 456
    rs1914819691,2
    --71627459(+) TTAATA/TTTTTA 1 -- ut310--------
    rs1831359191,2
    --71627484(+) CCACTA/GAACAT 1 -- ut310--------
    rs1877758251,2
    --71627494(+) TGGCAC/TTAAAC 1 -- ut310--------
    rs123458861,2
    C,F,A--71627525(+) ATTACG/TCCAAA 1 -- ut31 ese313Minor allele frequency- T:0.20NA NS WA CSA EA 452
    rs1909579081,2
    --71627557(+) ATCCTC/GTCTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKACG (71627445 - 71629039 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRKACG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422258CNV Duplication17116639
    dgv8245n71CNV Loss21882294
    dgv8244n71CNV Loss21882294
    dgv8246n71CNV Loss21882294
    dgv8243n71CNV Loss21882294
    nsv466393CNV Gain19166990
    nsv466397CNV Gain19166990
    nsv893416CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKACG
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKACG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176893    OMIM disorders: --

    1 disease for PRKACG:    
    About MalaCards
    primary pigmented nodular adrenocortical disease


    Find genes that share disorders with PRKACG           About GenesLikeMe

    1 Novoseek inferred disease relationship for PRKACG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 2072910 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRKACG (1 document)

    Export disorders for PRKACG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKACG gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with PRKACG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. (PubMed id 9598317)1, 2, 3 Reinton N.... Tasken K. (Genomics 1998)
    2. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PubMed id 2342480)1, 2, 3 Beebe S.J.... Jahnsen T. (Mol. Endocrinol. 1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Role of phosphorylation in the nuclear biology of HIV-1. (PubMed id 21651489)1 Francis A.C....Cereseto A. (Curr. Med. Chem. 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction. (PubMed id 21745501)1 Rom S....Peruzzi F. (Biochim. Biophys. Acta 2011)
    9. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains. (PubMed id 22114277)1 Xu H....Haughey N.J. (J. Neurosci. 2011)
    10. Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection. (PubMed id 20392842)1 Barnitz R.A....Lenardo M.J. (J. Virol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5568 HGNC: 9382 AceView: PRKACG Ensembl:ENSG00000165059 euGenes: HUgn5568
    ECgene: PRKACG Kegg: 5568 H-InvDB: PRKACG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKACG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKACG Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/prkacg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKACG gene:
    Search GeneIP for patents involving PRKACG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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