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Aliases for PRKACG Gene

Aliases for PRKACG Gene

  • Protein Kinase, CAMP-Dependent, Catalytic, Gamma 2 3
  • EC 2.7.11.11 4 63
  • PKA C-Gamma 3 4
  • CAMP-Dependent Protein Kinase Catalytic Subunit Gamma 3
  • Serine(Threonine) Protein Kinase 3
  • EC 2.7.11 63
  • BDPLT19 3
  • PKACg 3
  • KAPG 3

External Ids for PRKACG Gene

Previous GeneCards Identifiers for PRKACG Gene

  • GC09M062671
  • GC09M063484
  • GC09M065197
  • GC09M067084
  • GC09M068857
  • GC09M070817
  • GC09M071627

Summaries for PRKACG Gene

Entrez Gene Summary for PRKACG Gene

  • Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKACG Gene

PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, Gamma) is a Protein Coding gene. Diseases associated with PRKACG include bleeding disorder, platelet-type, 19 and primary pigmented nodular adrenocortical disease. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include cAMP-dependent protein kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKACG Gene

  • Phosphorylates a large number of substrates in the cytoplasm and the nucleus

Tocris Summary for PRKACG Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKACG Gene

Genomics for PRKACG Gene

Regulatory Elements for PRKACG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKACG Gene

Start:
69,012,505 bp from pter
End:
69,014,123 bp from pter
Size:
1,619 bases
Orientation:
Minus strand

Genomic View for PRKACG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKACG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKACG Gene

Proteins for PRKACG Gene

  • Protein details for PRKACG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22612-KAPCG_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit gamma
    Protein Accession:
    P22612
    Secondary Accessions:
    • O60850
    • Q5VZ02
    • Q86YI1

    Protein attributes for PRKACG Gene

    Size:
    351 amino acids
    Molecular mass:
    40434 Da
    Quaternary structure:
    • A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
    SequenceCaution:
    • Sequence=AAC41690.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PRKACG Gene

Proteomics data for PRKACG Gene at MOPED

Post-translational modifications for PRKACG Gene

  • Ubiquitination at Lys190
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKACG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRKACG Gene

Suggested Antigen Peptide Sequences for PRKACG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22612

UniProtKB/Swiss-Prot:

KAPCG_HUMAN :
  • P22612
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKACG: view

Function for PRKACG Gene

Molecular function for PRKACG Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,catalytic,gamma subunit,retroposon inserted inside the STM7 gene and transcribed in the opposite (antisense) strand specifically transcribed in primate testicular germ cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP
UniProtKB/Swiss-Prot Function:
Phosphorylates a large number of substrates in the cytoplasm and the nucleus

Enzyme Numbers (IUBMB) for PRKACG Gene

Gene Ontology (GO) - Molecular Function for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004691 cAMP-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKACG: view

Phenotypes for PRKACG Gene

genes like me logo Genes that share phenotypes with PRKACG: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKACG

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRKACG Gene

Localization for PRKACG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKACG Gene COMPARTMENTS Subcellular localization image for PRKACG gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0097546 ciliary base TAS --
genes like me logo Genes that share ontologies with PRKACG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKACG Gene

Pathways for PRKACG Gene

SuperPathways for PRKACG Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with PRKACG: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Circadian Rhythms in human,mouse,rat
    • Gap Junctions in human,mouse,rat

Gene Ontology (GO) - Biological Process for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0003091 renal water homeostasis TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
genes like me logo Genes that share ontologies with PRKACG: view

Compounds for PRKACG Gene

(5) Tocris Compounds for PRKACG Gene

Compound Action Cas Number
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog [93602-66-5]
H 89 dihydrochloride Protein kinase A inhibitor [130964-39-5]
KT 5720 Selective protein kinase A inhibitor [108068-98-0]
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor [121932-06-7]
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor [201422-03-9]

(3) ApexBio Compounds for PRKACG Gene

Compound Action Cas Number
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC [486-35-1]
H 89 2HCl Potent PKA inhibitor [130964-39-5]
PKA inhibitor fragment (6-22) amide [121932-06-7]

(3) HMDB Compounds for PRKACG Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cyclic AMP
  • Cyclic AMP
60-92-4

(12) Novoseek inferred chemical compound relationships for PRKACG Gene

Compound -log(P) Hits PubMed IDs
serine 73 44
threonine 55.3 1
pkcs 50.9 2
tyrosine 44.4 10
phosphoenolpyruvate 43 1
genes like me logo Genes that share compounds with PRKACG: view

Transcripts for PRKACG Gene

mRNA/cDNA for PRKACG Gene

(10) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKACG Gene

Protein kinase, cAMP-dependent, catalytic, gamma:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKACG

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKACG Gene

No ASD Table

Relevant External Links for PRKACG Gene

GeneLoc Exon Structure for
PRKACG
ECgene alternative splicing isoforms for
PRKACG

Expression for PRKACG Gene

mRNA expression in normal human tissues for PRKACG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKACG Gene

This gene is overexpressed in Testis (52.1).

Protein differential expression in normal tissues for PRKACG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (19.7) and Ovary (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKACG Gene

SOURCE GeneReport for Unigene cluster for PRKACG Gene Hs.158029

mRNA Expression by UniProt/SwissProt for PRKACG Gene

P22612-KAPCG_HUMAN
Tissue specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript
genes like me logo Genes that share expressions with PRKACG: view

In Situ Assay Products

No data available for Expression partners for PRKACG Gene

Orthologs for PRKACG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKACG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKACG 35
  • 99.15 (n)
  • 98.86 (a)
PRKACG 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii prkacaa 35
  • 76.35 (n)
  • 81.48 (a)
prkacaa 36
  • 81 (a)
ManyToMany
prkacab 36
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12069 37
  • 47 (a)
Pka-C1 37
  • 75 (a)
Pka-C2 37
  • 48 (a)
CG12069 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F47F2.1a 37
  • 49 (a)
F47F2.1b 37
  • 49 (a)
kin-1 36
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL115C 35
  • 57.65 (n)
  • 48.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07205g 35
  • 51.29 (n)
  • 50.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK3 35
  • 51.16 (n)
  • 48.84 (a)
TPK1 36
  • 38 (a)
ManyToMany
TPK2 36
  • 41 (a)
ManyToMany
TPK3 36
  • 38 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.32856 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10961 36
  • 27 (a)
ManyToMany
Species with no ortholog for PRKACG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKACG Gene

ENSEMBL:
Gene Tree for PRKACG (if available)
TreeFam:
Gene Tree for PRKACG (if available)

Paralogs for PRKACG Gene

Paralogs for PRKACG Gene

genes like me logo Genes that share paralogs with PRKACG: view

Variants for PRKACG Gene

Sequence variations from dbSNP and Humsavar for PRKACG Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3730386 - 69,013,291(-) TCAAG(C/G)ATCTG reference, missense
rs3750373 -- 69,013,541(-) GTGAC(C/G)GACTT synonymous-codon, reference
rs3812538 -- 69,012,840(+) TGGGG(C/G)GGGGT utr-variant-3-prime
rs3812539 -- 69,012,841(+) GGGGG(G/T)GGGTG utr-variant-3-prime
rs3841198 -- 69,012,844(+) GGGGG(-/G/GG)TGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRKACG Gene

Variant ID Type Subtype PubMed ID
esv2422258 CNV Duplication 17116639
nsv466393 CNV Gain 19166990
nsv466397 CNV Gain 19166990
nsv893416 CNV Gain 21882294
dgv8243n71 CNV Loss 21882294
dgv8244n71 CNV Loss 21882294
dgv8245n71 CNV Loss 21882294
dgv8246n71 CNV Loss 21882294

Relevant External Links for PRKACG Gene

HapMap Linkage Disequilibrium report
PRKACG
Human Gene Mutation Database (HGMD)
PRKACG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACG Gene

Disorders for PRKACG Gene

UniProtKB/Swiss-Prot

KAPCG_HUMAN
  • Bleeding disorder, platelet-type 19 (BDPLT19) [MIM:616176]: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. {ECO:0000269 PubMed:25061177}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for PRKACG Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PRKACG

Human Genome Epidemiology (HuGE) Navigator
PRKACG
genes like me logo Genes that share disorders with PRKACG: view

No data available for OMIM , University of Copenhagen DISEASES and Genatlas for PRKACG Gene

Publications for PRKACG Gene

  1. The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. (PMID: 9598317) Reinton N. … Tasken K. (Genomics 1998) 2 3 4
  2. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PMID: 2342480) Beebe S.J. … Jahnsen T. (Mol. Endocrinol. 1990) 2 3 4
  3. A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene. (PMID: 25061177) Manchev V.T. … Raslova H. (Blood 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Phosphorylation of HIV Nef by cAMP-dependent protein kinase. (PMID: 15629779) Li P.L. … Ruprecht R.M. (Virology 2005) 3

Products for PRKACG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Circadian Rhythms in human,mouse,rat
    • Gap Junctions in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PRKACG
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PRKACG
    • Block miRNA regulation of PRKACG using miScript Target Protectors

    Sources for PRKACG Gene

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