Aliases for PRKACG Gene
External Ids for PRKACG Gene
Previous GeneCards Identifiers for PRKACG Gene
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKACG Gene
PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, Gamma) is a Protein Coding gene. Diseases associated with PRKACG include bleeding disorder, platelet-type, 19 and primary pigmented nodular adrenocortical disease. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include cAMP-dependent protein kinase activity. An important paralog of this gene is PRKACA.
UniProtKB/Swiss-Prot for PRKACG Gene
Phosphorylates a large number of substrates in the cytoplasm and the nucleus
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).