Aliases for PRKACG Gene
External Ids for PRKACG Gene
Previous GeneCards Identifiers for PRKACG Gene
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKACG Gene
PRKACG (Protein Kinase CAMP-Activated Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PRKACG include bleeding disorder, platelet-type, 19 and severe autosomal recessive macrothrombocytopenia. Among its related pathways are cGMP-PKG signaling pathway and Insulin secretion. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.
UniProtKB/Swiss-Prot for PRKACG Gene
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.