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Aliases for PRKACG Gene

Aliases for PRKACG Gene

  • Protein Kinase CAMP-Activated Catalytic Subunit Gamma 2 3
  • Protein Kinase, CAMP-Dependent, Gamma Catalytic Subunit 2 3 5
  • Protein Kinase, CAMP-Dependent, Catalytic, Gamma 2 3
  • EC 2.7.11.11 4 63
  • PKA C-Gamma 3 4
  • Serine(Threonine) Protein Kinase 3
  • EC 2.7.11 63
  • BDPLT19 3
  • PKACg 3
  • KAPG 3

External Ids for PRKACG Gene

Previous GeneCards Identifiers for PRKACG Gene

  • GC09M062671
  • GC09M063484
  • GC09M065197
  • GC09M067084
  • GC09M068857
  • GC09M070817
  • GC09M071627

Summaries for PRKACG Gene

Entrez Gene Summary for PRKACG Gene

  • Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKACG Gene

PRKACG (Protein Kinase CAMP-Activated Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PRKACG include bleeding disorder, platelet-type, 19 and severe autosomal recessive macrothrombocytopenia. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKACG Gene

  • Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Tocris Summary for PRKACG Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKACG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKACG Gene

Genomics for PRKACG Gene

Regulatory Elements for PRKACG Gene

Genomic Location for PRKACG Gene

Chromosome:
9
Start:
69,012,505 bp from pter
End:
69,014,123 bp from pter
Size:
1,619 bases
Orientation:
Minus strand

Genomic View for PRKACG Gene

Genes around PRKACG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKACG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKACG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKACG Gene

Proteins for PRKACG Gene

  • Protein details for PRKACG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22612-KAPCG_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit gamma
    Protein Accession:
    P22612
    Secondary Accessions:
    • O60850
    • Q5VZ02
    • Q86YI1

    Protein attributes for PRKACG Gene

    Size:
    351 amino acids
    Molecular mass:
    40434 Da
    Quaternary structure:
    • A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
    SequenceCaution:
    • Sequence=AAC41690.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for PRKACG Gene

Proteomics data for PRKACG Gene at MOPED

Post-translational modifications for PRKACG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKACG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRKACG Gene

Suggested Antigen Peptide Sequences for PRKACG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22612

UniProtKB/Swiss-Prot:

KAPCG_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKACG: view

Function for PRKACG Gene

Molecular function for PRKACG Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,catalytic,gamma subunit,retroposon inserted inside the STM7 gene and transcribed in the opposite (antisense) strand specifically transcribed in primate testicular germ cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP.
UniProtKB/Swiss-Prot Function:
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Enzyme Numbers (IUBMB) for PRKACG Gene

Gene Ontology (GO) - Molecular Function for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004691 cAMP-dependent protein kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with PRKACG: view
genes like me logo Genes that share phenotypes with PRKACG: view

Human Phenotype Ontology for PRKACG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRKACG Gene

Localization for PRKACG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKACG Gene COMPARTMENTS Subcellular localization image for PRKACG gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRKACG Gene

Pathways & Interactions for PRKACG Gene

SuperPathways for PRKACG Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Circadian entrainment
4 Aquaporin-mediated transport
5 G-Beta Gamma Signaling
genes like me logo Genes that share pathways with PRKACG: view

SIGNOR curated interactions for PRKACG Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRKACG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006833 water transport TAS --
genes like me logo Genes that share ontologies with PRKACG: view

Drugs & Compounds for PRKACG Gene

(13) Drugs for PRKACG Gene - From: HMDB, ApexBio, Novoseek, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
cyclic amp Experimental Pharma 0
Daphnetin Pharma Protein kinases inhibitor for EGFR/PKA/PKC 0
H 89 2HCl Pharma Potent PKA inhibitor 0
PKA inhibitor fragment (6-22) amide Pharma 0

(10) Additional Compounds for PRKACG Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
8-Bromo-cAMP, sodium salt
76939-46-3
cAMPS-Rp, triethylammonium salt
151837-09-1
cAMPS-Sp, triethylammonium salt
93602-66-5
cGMP Dependent Kinase Inhibitor Peptide
82801-73-8

(5) Tocris Compounds for PRKACG Gene

Compound Action Cas Number
8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog 76939-46-3
cAMPS-Rp, triethylammonium salt cAMP antagonist 151837-09-1
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog 93602-66-5
cGMP Dependent Kinase Inhibitor Peptide Inhibitor of protein kinases G and A 82801-73-8
KT 5720 Selective protein kinase A inhibitor 108068-98-0

(3) ApexBio Compounds for PRKACG Gene

Compound Action Cas Number
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
H 89 2HCl Potent PKA inhibitor 130964-39-5
PKA inhibitor fragment (6-22) amide 121932-06-7
genes like me logo Genes that share compounds with PRKACG: view

Transcripts for PRKACG Gene

mRNA/cDNA for PRKACG Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKACG Gene

Protein kinase, cAMP-dependent, catalytic, gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKACG Gene

No ASD Table

Relevant External Links for PRKACG Gene

GeneLoc Exon Structure for
PRKACG
ECgene alternative splicing isoforms for
PRKACG

Expression for PRKACG Gene

mRNA expression in normal human tissues for PRKACG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKACG Gene

This gene is overexpressed in Testis (x52.1).

Protein differential expression in normal tissues from HIPED for PRKACG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (19.7) and Ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKACG Gene



SOURCE GeneReport for Unigene cluster for PRKACG Gene Hs.158029

mRNA Expression by UniProt/SwissProt for PRKACG Gene

P22612-KAPCG_HUMAN
Tissue specificity: Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.
genes like me logo Genes that share expression patterns with PRKACG: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PRKACG Gene

Orthologs for PRKACG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKACG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKACG 35
  • 99.15 (n)
  • 98.86 (a)
PRKACG 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii prkacaa 35
  • 76.35 (n)
  • 81.48 (a)
prkacaa 36
  • 81 (a)
ManyToMany
prkacab 36
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12069 37
  • 47 (a)
Pka-C1 37
  • 75 (a)
Pka-C2 37
  • 48 (a)
CG12069 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F47F2.1a 37
  • 49 (a)
F47F2.1b 37
  • 49 (a)
kin-1 36
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL115C 35
  • 57.65 (n)
  • 48.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07205g 35
  • 51.29 (n)
  • 50.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK3 35
  • 51.16 (n)
  • 48.84 (a)
TPK1 36
  • 38 (a)
ManyToMany
TPK2 36
  • 41 (a)
ManyToMany
TPK3 36
  • 38 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.32856 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10961 36
  • 27 (a)
ManyToMany
Species with no ortholog for PRKACG:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKACG Gene

ENSEMBL:
Gene Tree for PRKACG (if available)
TreeFam:
Gene Tree for PRKACG (if available)

Paralogs for PRKACG Gene

Paralogs for PRKACG Gene

genes like me logo Genes that share paralogs with PRKACG: view

Variants for PRKACG Gene

Sequence variations from dbSNP and Humsavar for PRKACG Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3730386 - 69,013,291(-) TCAAG(C/G)ATCTG reference, missense
VAR_040595 -
VAR_072672 Bleeding disorder, platelet-type 19 (BDPLT19)
rs3841198 -- 69,012,844(+) GGGGG(-/G/GG)TGAGG utr-variant-3-prime
rs3750373 -- 69,013,541(-) GTGAC(C/G)GACTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PRKACG Gene

Variant ID Type Subtype PubMed ID
esv2422258 CNV Duplication 17116639
nsv466393 CNV Gain 19166990
nsv466397 CNV Gain 19166990
nsv893416 CNV Gain 21882294
dgv8243n71 CNV Loss 21882294
dgv8244n71 CNV Loss 21882294
dgv8245n71 CNV Loss 21882294
dgv8246n71 CNV Loss 21882294

Variation tolerance for PRKACG Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKACG Gene

HapMap Linkage Disequilibrium report
PRKACG
Human Gene Mutation Database (HGMD)
PRKACG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACG Gene

Disorders for PRKACG Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRKACG Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 19
  • bleeding disorder, platelet-type 19
severe autosomal recessive macrothrombocytopenia
stormorken syndrome
  • thrombocytopathy, asplenia and miosis
primary pigmented nodular adrenocortical disease
  • pigmented nodular adrenocortical disease, primary, 2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

KAPCG_HUMAN
  • Bleeding disorder, platelet-type 19 (BDPLT19) [MIM:616176]: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. {ECO:0000269 PubMed:25061177}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PRKACG

Human Genome Epidemiology (HuGE) Navigator
PRKACG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKACG
genes like me logo Genes that share disorders with PRKACG: view

No data available for Genatlas for PRKACG Gene

Publications for PRKACG Gene

  1. The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. (PMID: 9598317) Reinton N. … Tasken K. (Genomics 1998) 2 3 4 67
  2. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PMID: 2342480) Beebe S.J. … Jahnsen T. (Mol. Endocrinol. 1990) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all. (PMID: 24189052) Desimmie B.A. … Pathak V.K. (J. Mol. Biol. 2014) 3
  5. A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene. (PMID: 25061177) Manchev V.T. … Raslova H. (Blood 2014) 3

Products for PRKACG Gene

Sources for PRKACG Gene

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