Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PRKACB Gene

protein-coding   GIFtS: 74
GCID: GC01P084543

Protein Kinase, CAMP-Dependent, Catalytic, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Kinase, CAMP-Dependent, Catalytic, Beta1 2     CAMP-Dependent Protein Kinase Catalytic Beta Subunit Isoform 4ab2
PKA C-Beta2 3     CAMP-Dependent Protein Kinase Catalytic Subunit Beta2
EC 2.7.11.113 8     Protein Kinase A Catalytic Subunit Beta2
PKACB2     EC 2.7.118

External Ids:    HGNC: 93811   Entrez Gene: 55672   Ensembl: ENSG000001428757   OMIM: 1768925   UniProtKB: P226943   

Export aliases for PRKACB gene to outside databases

Previous GC identifers: GC01P084937 GC01P083681 GC01P083832 GC01P083966 GC01P084255 GC01P084316 GC01P082654


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PRKACB Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and
is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants
encoding distinct isoforms have been observed. (provided by RefSeq, Jun 2011)

GeneCards Summary for PRKACB Gene:
PRKACB (protein kinase, cAMP-dependent, catalytic, beta) is a protein-coding gene. Diseases associated with PRKACB include primary pigmented nodular adrenocortical disease, and prion disease. GO annotations related to this gene include cAMP-dependent protein kinase activity and magnesium ion binding. An important paralog of this gene is PRKX.

UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates
diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of
microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as
well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of
compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
these subunits, leading to their subsequent proteolysis

summary for PRKACB Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKACB gene promoter:
         TBP   STAT1   Sox5   AML1a   S8   POU2F1   HOXA5   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKACB promoter sequence
   Search Chromatin IP Primers for PRKACB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKACB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p36.1

PRKACB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKACB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P084543:  view genomic region     (about GC identifiers)

Start:
84,543,745 bp from pter      End:
84,704,181 bp from pter
Size:
160,437 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit beta  
Size: 351 amino acids; 40623 Da
Cofactor: Magnesium
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of
the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the
inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic
subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity)
Sequence caution: Sequence=BAD92426.1; Type=Frameshift; Positions=322;
Secondary accessions: B1APG4 B4DKB0 B4E2Q1 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3
Q5CZ92 Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09
Alternative splicing: 10 isoforms:  P22694-1   P22694-2   P22694-3   P22694-4   P22694-5   P22694-6   P22694-7   P22694-8   
P22694-9   P22694-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKACB: NX_P22694

Explore proteomics data for PRKACB at MOPED

Post-translational modifications: 

  • Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively
    (By similarity)1
  • Ubiquitination2 at Lys93
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKACB (P22694) (see all 17)
     TDFGFAK  YYAMKIL  LKPENLL  YLAPEII 


    See PRKACB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001229786.1  NP_001229787.1  NP_001229788.1  NP_001229789.1  NP_001229790.1  NP_001229791.1  NP_002722.1  NP_891993.1  
    NP_997461.1  

    ENSEMBL proteins: 
     ENSP00000359723   ENSP00000359722   ENSP00000359719   ENSP00000401252   ENSP00000359718  
     ENSP00000390906   ENSP00000392275   ENSP00000393654   ENSP00000359714   ENSP00000397175  
     ENSP00000399326   ENSP00000378315   ENSP00000378314   ENSP00000359716  
    Reactome Protein details: P22694

    PRKACB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PRKACB (PKA C beta)
    Enzo Life Sciences proteins for PRKACB
    OriGene Purified Protein for PRKACB
    OriGene Protein Over-expression Lysate for PRKACB
    OriGene MassSpec for PRKACB
    OriGene Custom Protein Services for PRKACB
    GenScript Custom Purified and Recombinant Proteins Services for PRKACB
    Novus Biologicals PRKACB Proteins
    Novus Biologicals PRKACB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PRKACB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKACB
    R&D Systems Antibodies for PRKACB (PKA C beta)
    OriGene Antibodies for PRKACB
    OriGene Custom Antibody Services for PRKACB
    Novus Biologicals PRKACB Antibodies
    Abcam antibodies for PRKACB (P22694, P22612, P17612)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKACB
    LSBio Antibodies in human, mouse, rat for PRKACB

    PRKACB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKACB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKACB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, catalytic, beta subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P22694

    ProtoNet protein and cluster: P22694

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    PRKACB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAPCB_HUMAN, P22694
    Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates
    diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of
    microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as
    well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of
    compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
    these subunits, leading to their subsequent proteolysis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cAMP

         Genatlas biochemistry entry for PRKACB:
    protein kinase,cAMP-dependent,catalytic,beta subunit

         Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12420224
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity IDA12420224
    GO:0004713protein tyrosine kinase activity ----
         
    PRKACB for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRKACB:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Increased cell death HMECs cel 
     Increased colony dispersion (i  Increases Tamoxifen sensitivit 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prkacb):
     behavior/neurological  embryogenesis  mortality/aging  nervous system  skeleton 

    PRKACB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKACB: Prkacbtm2Gsm Prkacbtm1Gsm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKACB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKACB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKACB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKACB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKACB:
    hsa-mir-19b-3p (MIRT031110), hsa-mir-93-5p (MIRT027986)

    Block miRNA regulation of human, mouse, rat PRKACB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKACB (see all 50):
    hsa-miR-194* hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPRKACB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKACB
    Predesigned siRNA for gene silencing in human, mouse, rat PRKACB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKACB

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKACB (see all 23)
    OriGene ORF clones in mouse, rat for PRKACB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKACB (NM_182948)
    Sino Biological Human cDNA Clone for PRKACB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKACB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKACB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKACB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KAPCB_HUMAN, P22694: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus
    (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    nucleus4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    PRKACB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PRKACB About   (see all 108)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    EGFR interacts with phospholipase C-gamma0.94
    Neurophysiological process PGE2 induced pain processing0.38
    PLC-gamma1 signalling0.94
    Signal transduction Calcium signaling0.35
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    3Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    4Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    5G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKACB (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for PRKACB (see all 39)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PRKACB (see all 8)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    AMPK signaling
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell


    Selected Reactome Pathways for PRKACB (see all 14)
        PKA activation
    PKA-mediated phosphorylation of key metabolic factors
    CREB phosphorylation through the activation of Adenylate Cyclase
    Regulation of insulin secretion
    PKA activation in glucagon signalling

    1 PharmGKB Pathway for PRKACB
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PRKACB) (see all 49):
        MAPK signaling pathway
    Ras signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    PRKACB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACB: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKACB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKACB (P226941, 2, 3 ENSP000003597194) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCAN1P538052, 3, ENSP000003207684MINT-7262390 I2D: score=1 STRING: ENSP00000320768
    FLNAP213332, 3, ENSP000003588664MINT-51380 I2D: score=1 STRING: ENSP00000358866
    CHEK1O147573, ENSP000002789164I2D: score=3 STRING: ENSP00000278916
    NGFRP081383, ENSP000001722294I2D: score=3 STRING: ENSP00000172229
    PKIAP619253, ENSP000003365524I2D: score=2 STRING: ENSP00000336552
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation IDA12420224

    PRKACB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKACB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    4 HMDB Compounds for PRKACB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for PRKACB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonothreonine-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PRKACB gene (9 alternative transcripts): 
    NM_001242857.1  NM_001242858.1  NM_001242859.1  NM_001242860.1  NM_001242861.1  NM_001242862.1  NM_002731.2  NM_182948.2  
    NM_207578.1  

    Unigene Cluster for PRKACB:

    Protein kinase, cAMP-dependent, catalytic, beta
    Hs.487325  [show with all ESTs]
    Unigene Representative Sequence: BX537705
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370689(uc001djj.3) ENST00000370688(uc001dji.3) ENST00000370685(uc001djl.3 uc010orv.2)
    ENST00000470673 ENST00000446538 ENST00000370684 ENST00000436133 ENST00000432111
    ENST00000450730 ENST00000370680(uc009wcf.2) ENST00000413538 ENST00000417530(uc001djo.2)
    ENST00000394839(uc001djq.3) ENST00000467507 ENST00000394838(uc010ort.2 uc001djp.3)
    ENST00000370682(uc001djn.3 uc010oru.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRKACB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKACB (see all 50):
    hsa-miR-194* hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPRKACB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRKACB
    Predesigned siRNA for gene silencing in human, mouse, rat PRKACB
    Clone
    Products:
         
    OriGene clones in human, mouse for PRKACB (see all 23)
    OriGene ORF clones in mouse, rat for PRKACB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKACB (NM_182948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKACB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRKACB
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKACB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKACB
      QuantiTect SYBR Green Assays in human, mouse, rat PRKACB
      QuantiFast Probe-based Assays in human, mouse, rat PRKACB

    Additional mRNA sequence: 

    AB209189.1 AB451239.1 AB451364.1 AK091420.1 AK296482.1 AK304322.1 AK304375.1 AK314550.1 
    AK316115.1 AL050208.1 AY927364.1 AY927365.1 AY927366.1 AY927367.1 AY927368.1 BC016285.1 
    BC035058.1 BX537705.1 BX641026.1 BX647515.1 CR936631.1 M34181.1 

    Selected DOTS entries (see all 26):

    DT.100027499  DT.91697967  DT.95365903  DT.95365890  DT.101967415  DT.448087  DT.100703337  DT.95188739 
    DT.95365892  DT.121464195  DT.91697969  DT.40198662  DT.121464196  DT.100667657  DT.121464188  DT.121464189 
    DT.100766434  DT.121464255  DT.99997562  DT.100644361  DT.100720932  DT.121464150  DT.121464203  DT.121464302 

    Selected AceView cDNA sequences (see all 291):

    AI964075 BQ230651 CR608646 AA252717 AI262796 BQ269531 BQ286167 BM712525 
    BM054863 AA455327 BM454631 BQ101211 CA418330 BU177126 AI357420 AA809434 
    NM_002731 CK431033 BM680117 CR619935 AI522214 AI620759 BQ189174 AU076749 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKACB (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
    SP1:              -                                               -     -     -                     
    SP2:              -                                                                                 
    SP3:                                                                                                
    SP4:                                -                             -     -     -                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for PRKACB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PRKACB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAAATATG
    PRKACB Expression
    About this image


    PRKACB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebellum
             Ventral/hypothalamic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PRKACB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKACB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487325

    UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
    Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is
    predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACB: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRKACB
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKACB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKACB
    QuantiTect SYBR Green Assays in human, mouse, rat PRKACB
    QuantiFast Probe-based Assays in human, mouse, rat PRKACB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKACB gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkacb1 , 5 protein kinase, cAMP dependent, catalytic, beta1, 5 85.01(n)1
    92.46(a)1
      3 (72.28 cM)5
    187491  NM_001164200.11  NP_001157672.11 
     1467295795 
    chicken
    (Gallus gallus)
    Aves PRKACB1 protein kinase, cAMP-dependent, catalytic, beta 85.51(n)
    90.2(a)
      424542  XM_422379.3  XP_422379.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKACB6
    protein kinase, cAMP-dependent, catalytic, beta
    79(a)
    1 ↔ 1
    GL343194.1(9373023-9421597)
    African clawed frog
    (Xenopus laevis)
    Amphibia kin-1-prov2 protein kinase, cAMP-dependent, catalytic, beta 80.61(n)    BC046697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640542 similar to protein kinase, cAMP dependent, catalytic, more 75.98(n)   393998  BC053227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-C11 , 3 anterior/posterior pattern formation,
    imaginal more3
    cAMP-dependent protein kinase 11
    82(a)
    (best of 4)3
    70.03(n)1
    83.38(a)1
      342841  NM_205950.31  NP_995672.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F47F2.1a3
    kin-11
    protein kinase3
    kin-11
    51(a)
    (best of 2)3
    70.13(n)1
    83.68(a)1
      X(3926462-3928330)3
    35654071  NM_061204.31  NP_493605.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK11 TPK1 54.92(n)
    51.11(a)
      853275   NP_012371.2 


    ENSEMBL Gene Tree for PRKACB (if available)
    TreeFam Gene Tree for PRKACB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PRKACB gene
    PRKX2  PRKACG2  PRKG22  PRKACA2  PRKG12  
    Selected SIMAP similar genes for PRKACB using alignment to 10 protein entries:     KAPCB_HUMAN (see all proteins) (see all similar genes):
    KIN27    PRKACA    PRKACG    PRKX    PRKY    RPS6KA2
    STK32A    RPS6KA1    RPS6KA5    PDPK2    AKT1    PDPK1
    PRKCB    PRKG2    AKT3    RPS6KA3    RPS6KA4    PRKCH

    PRKACB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PRKACB (see all 2860)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588013211,2
    C--82793556(+) CACAGA/TGGGAA 8 -- int10--------
    rs715829171,2
    C--84544793(+) ATCATAATCAT/-
            
    GAAAA
    2 -- cds11Minor allele frequency- -:0.50NA 2
    rs1507280531,2
    --84560401(+) TATTAG/TTTTTT 2 -- us2k10--------
    rs1177392031,2
    C,F--84560541(+) AATTAT/GGCACA 2 -- us2k11Minor allele frequency- G:0.05EA 120
    rs120590741,2
    C,H--84560754(+) ACAACA/GCAGAA 2 -- us2k13Minor allele frequency- G:0.04EA NS WA 270
    rs1924222701,2
    --84560920(+) TATGCA/GTCTAT 2 -- us2k10--------
    rs57757761,2
    C--84560930(+) TTTTT-/T/TT  
            
    GCGCT
    2 -- int1 trp31NA 2
    rs1401692291,2
    --84560981(+) ATCCAA/CAAGTT 2 -- us2k10--------
    rs350003191,2
    C,F,H--84561032(+) AATTGC/ACAGGG 2 -- us2k118Minor allele frequency- A:0.08NS EA NA 2220
    rs1135957941,2
    F--84561045(+) CAAATC/GCTGCT 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for PRKACB (84543745 - 84704181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PRKACB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1732CNV Loss18451855
    nsv871656CNV Loss21882294
    nsv871731CNV Loss21882294
    nsv871655CNV Loss21882294
    nsv871375CNV Loss21882294
    dgv263n71CNV Loss21882294
    nsv830414CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKACB
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKACB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 176892    OMIM disorders: --

    19 diseases for PRKACB:    
    About MalaCards
    primary pigmented nodular adrenocortical disease    prion disease    neurologic diseases    osteoporosis
    dilated cardiomyopathy    cholera    hiv-1    tonsillitis
    colorectal cancer    obesity    prostatitis    prostate cancer
    alzheimer's disease    cerebritis    endotheliitis    neuronitis
    breast cancer    thyroiditis    malaria


    PRKACB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKACB
    Human Genome Epidemiology (HuGE) Navigator: PRKACB (2 documents)

    Export disorders for PRKACB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PRKACB gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with PRKACB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene. (PubMed id 12420224)1, 2 Wu K.-J.... Dalla-Favera R. (Oncogene 2002)
    5. Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. (PubMed id 11589697)1, 2 Orstavik S....Skalhegg B.S. (Eur. J. Biochem. 2001)
    6. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PubMed id 2342480)1, 2 Beebe S.J.... Jahnsen T. (Mol. Endocrinol. 1990)
    7. Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. (PubMed id 19573263)1, 9 Shelton R.C....Lewis D.A. (Int. J. Neuropsychopharmacol. 2009)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5567 HGNC: 9381 AceView: PRKACB Ensembl:ENSG00000142875 euGenes: HUgn5567
    ECgene: PRKACB Kegg: 5567 H-InvDB: PRKACB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PRKACB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKACB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/prkacb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRKACB gene:
    Search GeneIP for patents involving PRKACB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKACB
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PRKACB (PKA C beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for PRKACB (PKA C beta)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRKACB   OriGene RNAi products in human, mouse, rat for PRKACB  
     OriGene qPCR primer pairs and template standards for PRKACB   OriGene Protein Over-expression Lysate for PRKACB  
     OriGene MassSpec something-or-other for PRKACB   OriGene clones in human, mouse for PRKACB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRKACB   OriGene Purified Protein for PRKACB  
     OriGene ORF clones in mouse, rat for PRKACB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKACB   OriGene Custom Protein Services for PRKACB  

     
     
     Block miRNA regulation of human, mouse, rat PRKACB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRKACB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKACB Predesigned siRNA for gene silencing in human, mouse, rat PRKACB
     QuantiFast Probe-based Assays in human, mouse, rat PRKACB QuantiTect SYBR Green Assays in human, mouse, rat PRKACB
     PCR Arrays including human, mouse, rat PRKACB Search Chromatin IP Primers for PRKACB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKACB  GeneGlobe Interaction Network for PRKACB
     Regulatory tfbs in PRKACB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRKACB GenScript cDNA clones with any tag delivered in your preferred vector for PRKACB
     GenScript Custom Assay Services for PRKACB GenScript Custom overexpressing Cell Line Services for PRKACB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PRKACB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRKACB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for PRKACB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRKACB antibodies
     PRKACB proteins
     PRKACB lysates
     Antibodies for PRKACB
     See all of Abcam's Antibodies, Kits and Proteins for PRKACB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRKACB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB
     SwitchGear 3'UTR luciferase reporter plasmids for PRKACB
     SwitchGear Promoter luciferase reporter plasmids for PRKACB
     ThermoFisher Antibodies for PRKACB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKACB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKACB
     LSBio Antibodies in human, mouse, rat for PRKACB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRKACB gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4