PRKACB Gene
protein-coding GIFtS: 67
GCID: GC01P084543
|
|
protein kinase, cAMP-dependent, catalytic, beta
| |
Aliases
for PRKACB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase, CAMP-Dependent, Catalytic, Beta1 2 | | CAMP-Dependent Protein Kinase Catalytic Beta Subunit Isoform 4ab2 | | PKA C-Beta2 3 | | CAMP-Dependent Protein Kinase Catalytic Subunit Beta2 | | EC 2.7.11.113 8 | | Protein Kinase A Catalytic Subunit Beta2 | | PKACb1 | | EC 2.7.118 | | PKACB2 | | |
Export aliases for PRKACB gene to outside databasesPrevious GC identifers: GC01P084937 GC01P083681 GC01P083832 GC01P083966 GC01P084255 GC01P084316 GC01P082654 |
Summaries
for PRKACB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKACB:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. Theinactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes thedissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomericcatalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit ofcAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have beenobserved. (provided by RefSeq, Jun 2011)
UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diversecellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics,chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation ofintracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatorysubunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequentproteolysis
 summary
for PRKACB: Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).
Gene Wiki entry for PRKACB
|
Genomic Views
for PRKACB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKACB gene promoter:
TBP STAT1 Sox5 AML1a S8 POU2F1 HOXA5 POU2F1b POU2F1a POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKACB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKACB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p36.1PRKACB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P084543: view genomic region
(about GC identifiers)
Start:
|
84,543,745 bp from pter |
End:
|
84,704,181 bp from pter |
Size:
|
160,437 bases |
Orientation:
|
plus strand |
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Proteins
for PRKACB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694 (See
protein sequence)Recommended Name: cAMP-dependent protein kinase catalytic subunit beta Size: 351 amino acids; 40623 Da
Cofactor: Magnesium
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of thedifferent regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactiveholoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. ThecAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomericcatalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity)
Sequence caution: Sequence=BAD92426.1; Type=Frameshift; Positions=322;
Secondary accessions: B1APG4 B4DKB0 B4E2Q1 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3 Q5CZ92Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09Alternative splicing: 10 isoforms: P22694-1 P22694-2 P22694-3 P22694-4 P22694-5 P22694-6 P22694-7 P22694-8 P22694-9 P22694-10 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PRKACB: NX_P22694
Post-translational modifications:
Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P22694
4/17 DME Specific Peptides for PRKACB (P22694) (see all 17)
PRKACB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (9 alternative transcripts):
NP_001229786.1 NP_001229787.1 NP_001229788.1 NP_001229789.1 NP_001229790.1 NP_001229791.1 NP_002722.1 NP_891993.1 NP_997461.1
ENSEMBL proteins: ENSP00000359723 ENSP00000359722 ENSP00000359719 ENSP00000401252 ENSP00000359718 ENSP00000390906 ENSP00000392275 ENSP00000393654 ENSP00000359714 ENSP00000397175 ENSP00000399326 ENSP00000378315 ENSP00000378314 ENSP00000359716 ENSP00000359713 Reactome Protein details: P22694
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PRKACB for ontologies About GeneDecksing
PRKACB Antibody Products:
Assay Products for PRKACB: |
Protein
Domains /
Families
for PRKACB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKACB for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P22694ProtoNet protein and cluster: P22694 1 Blocks protein family: IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domain |
Function
for PRKACB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diversecellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics,chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation ofintracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatorysubunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequentproteolysisCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by cAMP Genatlas biochemistry entry for PRKACB:protein kinase,cAMP-dependent,catalytic,beta subunit
Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PRKACB (NM_182948) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKACB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PRKACB for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for PRKACB:
Animal Models:
Mouse knock-outs for PRKACB: Prkacbtm2Gsm Prkacbtm1Gsm
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Prkacb):
PRKACB for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRKACB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/100 super-pathways (see all 100) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PKA activation in glucagon signalling | | | 3 | DAG and IP3 signaling | | | 4 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 5 | Opioid Signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/33 EMD Millipore Pathways for PRKACB (see all 33)
5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKACB (see all 52)
5/39  GeneGo (Thomson Reuters) Pathways for PRKACB (see all 39)
5/7  BioSystems Pathways for PRKACB (see all 7)
5/60 
Reactome Pathways for PRKACB (see all 60)
1  PharmGKB Pathway for PRKACB
5/27 
Kegg Pathways (Kegg details for PRKACB) (see all 27):
PRKACB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKACB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/182 Interacting proteins for PRKACB (P226941, 2, 3 ENSP000003597194) via UniProtKB, MINT, STRING, and/or I2D (see all 182)About this table
Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table
PRKACB for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKACB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for PRKACB available from Tocris Bioscience About this table
4 HMDB Compounds for PRKACB About this table
1 DrugBank Compound for PRKACB About this table
Search CenterWatch for drugs/clinical trials and news about PRKACB / KAPCB
|
Transcripts
for PRKACB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKACB gene (9 alternative transcripts): NM_001242857.1 NM_001242858.1 NM_001242859.1 NM_001242860.1 NM_001242861.1 NM_001242862.1 NM_002731.2 NM_182948.2 NM_207578.1 Unigene Cluster for PRKACB: Protein kinase, cAMP-dependent, catalytic, beta Hs.487325 [show with all ESTs]Unigene Representative Sequence: BX53770517 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370689(uc001djj.3) ENST00000370688(uc001dji.3) ENST00000370685(uc001djl.3 uc010orv.2)
ENST00000470673 ENST00000446538 ENST00000370684 ENST00000436133 ENST00000432111
ENST00000450730 ENST00000370680(uc009wcf.2) ENST00000413538 ENST00000417530(uc001djo.2)
ENST00000394839(uc001djq.3) ENST00000467507 ENST00000394838(uc010ort.2 uc001djp.3)
ENST00000370682(uc001djn.3 uc010oru.2) ENST00000370679
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PRKACB (NM_182948) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKACB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB |
Additional cDNA sequence: AB209189.1 AB451239.1 AB451364.1 AK091420.1 AK296482.1 AK304322.1 AK304375.1 AK314550.1 AK316115.1 AL050208.1 AY927364.1 AY927365.1 AY927366.1 AY927367.1 AY927368.1 BC016285.1 BC035058.1 BX537705.1 BX641026.1 BX647515.1 CR936631.1 M34181.1 24/26 DOTS entries (see all 26): DT.100027499 DT.91697967 DT.95365903 DT.95365890 DT.101967415 DT.448087 DT.100703337 DT.95188739 DT.95365892 DT.121464195 DT.91697969 DT.40198662 DT.121464196 DT.100667657 DT.121464188 DT.121464189 DT.100766434 DT.121464255 DT.99997562 DT.100644361 DT.100720932 DT.121464150 DT.121464203 DT.121464302 24/291 AceView cDNA sequences (see all 291): BE709211 BQ269531 AI964075 AI262796 BQ286167 BQ101211 BM454631 AA455327 BM712525 CA418330 BU177126 BM054863 AA809434 AI357420 NM_002731 CK431033 BM680117 CR619935 BQ189174 AI522214 AI863528 AU076749 AA256017 AI620759
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PRKACB (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRKACB
|
Expression
for PRKACB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKACB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAAATATG
About this image
See PRKACB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKACB
SOURCE GeneReport for Unigene cluster: Hs.487325
UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 ispredominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain
SABiosciences Expression via Pathway-Focused PCR Arrays including PRKACB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKACB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKACB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKACB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKACB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB |
Orthologs
for PRKACB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for PRKACB gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PRKACB1 |
protein kinase, cAMP-dependent, catalytic, beta |
85.51(n)
90.2(a) |
|
424542 XM_422379.2 XP_422379.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PRKACB6 |
-- |
90(a) |
1 ↔ 1 |
GL343194.1(9373023-9421594) |
African clawed frog
(Xenopus laevis) |
Amphibia |
kin-1-prov2 |
protein kinase, cAMP-dependent, catalytic, beta |
80.61(n) |
|
BC046697.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc640542 |
similar to protein kinase, cAMP dependent, catalytic, more |
75.98(n) |
|
393998 BC053227.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pka-C11 , 3 |
anterior/posterior pattern formation,
imaginal more3
cAMP-dependent protein kinase 11 |
82(a)
(best of 4)3
70.03(n)1
83.38(a)1 |
|
342841 NM_205950.21 NP_995672.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F47F2.1a3 |
protein kinase |
51(a)
(best of 2) |
|
X(3926462-3928330) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TPK21 |
Tpk2p |
58.33(n)
54.67(a) |
|
855898 NP_015121.1 |
ENSEMBL Gene Tree for PRKACB (if available)
TreeFam Gene Tree for PRKACB (if available) |
Paralogs
for PRKACB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRKACB gene
- PRKX2 PRKACG2 PRKG22 PRKACA2 PRKG12
18/166 SIMAP similar genes for PRKACB using alignment to 11 protein entries: KAPCB_HUMAN (see all proteins)
(see all similar genes):KIN27 PRKACA PRKACG PRKX PKN2 PRKY
RPS6KA2 RPS6KA1 STK32A RPS6KA5 PDPK2 PDPK1
PRKCB PRKG2 RPS6KA3 SGK2 RPS6KA4 PRKCH
PRKACB for paralogs About GeneDecksing
|
Genomic Variants
for PRKACB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKACB (84543745 - 84704181 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKACB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKACB |
|
Disorders
/ Diseases
for PRKACB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKACB for disorders About GeneDecksing
OMIM gene information: 176892
OMIM disorders: --
12  diseases for PRKACB: About MalaCardsprimary pigmented nodular adrenocortical disease prion disease neurologic diseases cholera
osteoporosis prostate cancer breast cancer prostatitis
immunodeficiency malaria carcinoma colorectal cancer
Human Genome Epidemiology (HuGE) Navigator: PRKACB (2 documents)
Export disorders for PRKACB gene to outside databases
|
Publications
for PRKACB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKACB gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with PRKACB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene. (PubMed id 12420224)1, 2 Wu K.-J.... Dalla-Favera R. (2002)
- Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. (PubMed id 11589697)1, 2 Orstavik S....Skalhegg B.S. (2001)
- Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PubMed id 2342480)1, 2 Beebe S.J.... Jahnsen T. (1990)
- Protein kinases A and C in post-mortem prefrontal cor tex from persons with major depression and normal controls. (PubMed id 19573263)1, 9 Shelton R.C....Lewis D.A. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
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External Searches for PRKACB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PRKACB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PRKACB gene
(According to HUGE)
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Specialized Databases showing PRKACB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PRKACB gene:
Search GeneIP for patents involving PRKACB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PRKACB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRKACB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKACB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKACB | | | OriGene Protein Over-expression Lysate for PRKACB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRKACB | | OriGene 3'-UTR Clone for PRKACB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRKACB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRKACB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKACB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKACB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKACB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKACB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKACB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB |
|  |  |  | | | | ThermoFisher Antibodies for PRKACB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB |
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