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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKACB Gene

protein-coding   GIFtS: 73
GCID: GC01P084543

Protein Kinase, CAMP-Dependent, Catalytic, Beta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase, CAMP-Dependent, Catalytic, Beta1 2     CAMP-Dependent Protein Kinase Catalytic Beta Subunit Isoform 4ab2
PKA C-Beta2 3     CAMP-Dependent Protein Kinase Catalytic Subunit Beta2
EC 2.7.11.113 8     Protein Kinase A Catalytic Subunit Beta2
PKACB2     EC 2.7.118

External Ids:    HGNC: 93811   Entrez Gene: 55672   Ensembl: ENSG000001428757   OMIM: 1768925   UniProtKB: P226943   

Export aliases for PRKACB gene to outside databases

Previous GC identifers: GC01P084937 GC01P083681 GC01P083832 GC01P083966 GC01P084255 GC01P084316 GC01P082654


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKACB Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and
is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants
encoding distinct isoforms have been observed. (provided by RefSeq, Jun 2011)

GeneCards Summary for PRKACB Gene: 
PRKACB (protein kinase, cAMP-dependent, catalytic, beta) is a protein-coding gene. Diseases associated with PRKACB include primary pigmented nodular adrenocortical disease, and prion disease, and among its related super-pathways are PKA activation in glucagon signalling and DAG and IP3 signaling. GO annotations related to this gene include cAMP-dependent protein kinase activity and magnesium ion binding. An important paralog of this gene is PRKX.

UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates
diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of
microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as
well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of
compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
these subunits, leading to their subsequent proteolysis

summary for PRKACB Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKACB gene promoter:
         TBP   STAT1   Sox5   AML1a   S8   POU2F1   HOXA5   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKACB promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKACB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKACB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p36.1

PRKACB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKACB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P084543:  view genomic region     (about GC identifiers)

Start:
84,543,745 bp from pter      End:
84,704,181 bp from pter
Size:
160,437 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit beta  
Size: 351 amino acids; 40623 Da
Cofactor: Magnesium
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of
the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the
inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic
subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus
(monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity)
Sequence caution: Sequence=BAD92426.1; Type=Frameshift; Positions=322;
Secondary accessions: B1APG4 B4DKB0 B4E2Q1 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3
Q5CZ92 Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09
Alternative splicing: 10 isoforms:  P22694-1   P22694-2   P22694-3   P22694-4   P22694-5   P22694-6   P22694-7   P22694-8   
P22694-9   P22694-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRKACB: NX_P22694

Explore proteomics data for PRKACB at MOPED 

Post-translational modifications:

  • UniProtKB: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively
    (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22694

  • 4/17 DME Specific Peptides for PRKACB (P22694) (see all 17)
     TDFGFAK  YYAMKIL  LKPENLL  YLAPEII 

    PRKACB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKACB Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001229786.1  NP_001229787.1  NP_001229788.1  NP_001229789.1  NP_001229790.1  NP_001229791.1  NP_002722.1  NP_891993.1  
    NP_997461.1  

    ENSEMBL proteins: 
     ENSP00000359723   ENSP00000359722   ENSP00000359719   ENSP00000401252   ENSP00000359718  
     ENSP00000390906   ENSP00000392275   ENSP00000393654   ENSP00000359714   ENSP00000397175  
     ENSP00000399326   ENSP00000378315   ENSP00000378314   ENSP00000359716  
    Reactome Protein details: P22694
    Human Recombinant Protein Products for PRKACB: 
    EMD Millipore Purified and/or Recombinant PRKACB Protein
    R&D Systems Recombinant & Natural Proteins for PRKACB (PKA C beta)
    Enzo Life Sciences proteins for PRKACB
    OriGene Purified Protein for PRKACB
    OriGene Protein Over-expression Lysate for PRKACB
    OriGene MassSpec for PRKACB 
    OriGene Custom Protein Services for PRKACB
    GenScript Custom Purified and Recombinant Proteins Services for PRKACB
    Novus Biologicals PRKACB Proteins
    Novus Biologicals PRKACB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    PRKACB for ontologies           About GeneDecksing



    PRKACB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKACB
    R&D Systems Antibodies for PRKACB (PKA C beta)
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    Abcam antibodies for PRKACB
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    ThermoFisher Antibodies for PRKACB
    LSBio Antibodies in human, mouse, rat for PRKACB 

    Assay Products for PRKACB: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRKACB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, catalytic, beta subunit 
    Protein kinase A
    Protein kinase A (PKA) family

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P22694

    ProtoNet protein and cluster: P22694

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    PRKACB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAPCB_HUMAN, P22694
    Function: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates
    diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of
    microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as
    well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of
    compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
    these subunits, leading to their subsequent proteolysis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cAMP

         Genatlas biochemistry entry for PRKACB:
    protein kinase,cAMP-dependent,catalytic,beta subunit

         Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12420224
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity IDA12420224
    GO:0004713protein tyrosine kinase activity ----
         
    PRKACB for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRKACB:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Increased cell death HMECs cel 
     Increased colony dispersion (i  Increases Tamoxifen sensitivit 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prkacb):
     behavior/neurological  embryogenesis  mortality/aging  nervous system  skeleton 

    PRKACB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKACB: Prkacbtm2Gsm Prkacbtm1Gsm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKACB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKACB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKACB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKACB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKACB
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKACB (see all 50):
    hsa-miR-194* hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPRKACB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PRKACB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRKACB (see all 25)
    OriGene ORF clones in mouse, rat for PRKACB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRKACB (NM_182948)
    Sino Biological Human cDNA Clone for PRKACB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKACB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACB
    Sirion Biotech Customized lentivirus for stable overexpression of PRKACB 
                         Customized lentivirus expression plasmids for stable overexpression of PRKACB 

    Cell Line
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    Search LifeMap BioReagents cell lines for PRKACB
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKACB About   (see all 106)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Ca-dependent events
    DAG and IP3 signaling0.94
    PLC beta mediated events0.65
    EGFR interacts with phospholipase C-gamma0.94
    G-protein mediated events0.64
    PLC-gamma1 signalling0.94
    Phospholipase C-mediated cascade0.57
    Ca-dependent events0.93
    Opioid Signalling0.55
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    Glucagon signaling in metabolic regulation0.69
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    4Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    514-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/33 EMD Millipore Pathways for PRKACB (see all 33)
        Cell cycle Role of APC in cell cycle regulation
    Development Ligand-independent activation of ESR1 and ESR2
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    G-protein signaling G-Protein beta/gamma signaling cascades
    G-protein signaling G-Protein alpha-s signaling cascades

    5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKACB (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    5/39 GeneGo (Thomson Reuters) Pathways for PRKACB (see all 39)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/7 BioSystems Pathways for PRKACB (see all 7)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    AMPK signaling
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways


    5/60        Reactome Pathways for PRKACB (see all 60)
        PKA activation
    Signaling by EGFR in Cancer
    Post NMDA receptor activation events
    Downstream signal transduction
    DARPP-32 events

    1 PharmGKB Pathway for PRKACB
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    5/43         Kegg Pathways  (Kegg details for PRKACB) (see all 43):
        MAPK signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Apoptosis


    PRKACB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKACB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for PRKACB (P226941, 2, 3 ENSP000003597194) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCAN1P538052, 3, ENSP000003207684MINT-7262390 I2D: score=1 STRING: ENSP00000320768
    FLNAP213332, 3, ENSP000003588664MINT-51380 I2D: score=1 STRING: ENSP00000358866
    NGFRP081383, ENSP000001722294I2D: score=3 STRING: ENSP00000172229
    PKIAP619253, ENSP000003365524I2D: score=2 STRING: ENSP00000336552
    PKIBQ9C0103, ENSP000003462274I2D: score=1 STRING: ENSP00000346227
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation IDA12420224

    PRKACB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PRKACB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PRKACB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    4 HMDB Compounds for PRKACB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for PRKACB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonothreonine-- --target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about PRKACB / KAPCB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKACB gene (9 alternative transcripts): 
    NM_001242857.1  NM_001242858.1  NM_001242859.1  NM_001242860.1  NM_001242861.1  NM_001242862.1  NM_002731.2  NM_182948.2  
    NM_207578.1  

    Unigene Cluster for PRKACB:

    Protein kinase, cAMP-dependent, catalytic, beta
    Hs.487325  [show with all ESTs]
    Unigene Representative Sequence: BX537705
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370689(uc001djj.3) ENST00000370688(uc001dji.3) ENST00000370685(uc001djl.3 uc010orv.2)
    ENST00000470673 ENST00000446538 ENST00000370684 ENST00000436133 ENST00000432111
    ENST00000450730 ENST00000370680(uc009wcf.2) ENST00000413538 ENST00000417530(uc001djo.2)
    ENST00000394839(uc001djq.3) ENST00000467507 ENST00000394838(uc010ort.2 uc001djp.3)
    ENST00000370682(uc001djn.3 uc010oru.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKACB (see all 50):
    hsa-miR-194* hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPRKACB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209189.1 AB451239.1 AB451364.1 AK091420.1 AK296482.1 AK304322.1 AK304375.1 AK314550.1 
    AK316115.1 AL050208.1 AY927364.1 AY927365.1 AY927366.1 AY927367.1 AY927368.1 BC016285.1 
    BC035058.1 BX537705.1 BX641026.1 BX647515.1 CR936631.1 M34181.1 

    24/26 DOTS entries (see all 26):

    DT.100027499  DT.91697967  DT.95365903  DT.95365890  DT.101967415  DT.448087  DT.100703337  DT.95188739 
    DT.95365892  DT.121464195  DT.91697969  DT.40198662  DT.121464196  DT.100667657  DT.121464188  DT.121464189 
    DT.100766434  DT.121464255  DT.99997562  DT.100644361  DT.100720932  DT.121464150  DT.121464203  DT.121464302 

    24/291 AceView cDNA sequences (see all 291):

    CK431033 BM680117 CR619935 AI522214 AI620759 BQ189174 AU076749 AI863528 
    CA952402 AI445555 AA256017 AA825737 BU161978 AA352938 AL596920 BX641026 
    AX746972 BM672022 AA250745 AI964075 BQ230651 CR608646 AA252717 AI262796 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PRKACB (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
    SP1:              -                                               -     -     -                     
    SP2:              -                                                                                 
    SP3:                                                                                                
    SP4:                                -                             -     -     -                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for PRKACB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKACB expression in normal human tissues (normalized intensities)      PRKACB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAAATATG
    PRKACB Expression
    About this image


    PRKACB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Olfactory Bulb   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocyte-derived macrophage   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See PRKACB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKACB

    SOURCE GeneReport for Unigene cluster: Hs.487325

    UniProtKB/Swiss-Prot: KAPCB_HUMAN, P22694
    Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is
    predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKACB: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRKACB gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkacb1 , 5 protein kinase, cAMP dependent, catalytic, beta1, 5 85.01(n)1
    92.46(a)1
      3 (72.28 cM)5
    187491  NM_001164200.11  NP_001157672.11 
     1467295795 
    chicken
    (Gallus gallus)
    Aves PRKACB1 protein kinase, cAMP-dependent, catalytic, beta 85.51(n)
    90.2(a)
      424542  XM_422379.2  XP_422379.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    PRKACB6
    Uncharacterized protein
    95(a)
    78(a)
    possible ortholog
    1 ↔ 1
    GL343212.1(2149026-2156519)
    GL343194.1(9373023-9421597)
    African clawed frog
    (Xenopus laevis)
    Amphibia kin-1-prov2 protein kinase, cAMP-dependent, catalytic, beta 80.61(n)    BC046697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640542 similar to protein kinase, cAMP dependent, catalytic, more 75.98(n)   393998  BC053227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-C11 , 3 anterior/posterior pattern formation,
    imaginal more3
    cAMP-dependent protein kinase 11
    82(a)
    (best of 4)3
    70.03(n)1
    83.38(a)1
      342841  NM_205950.21  NP_995672.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F47F2.1a3 protein kinase 51(a)
    (best of 2)
      X(3926462-3928330)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK21 Tpk2p 58.33(n)
    54.67(a)
      855898   NP_015121.1 


    ENSEMBL Gene Tree for PRKACB (if available)
    TreeFam Gene Tree for PRKACB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKACB gene
    PRKX2  PRKACG2  PRKG22  PRKACA2  PRKG12  
    18/141 SIMAP similar genes for PRKACB using alignment to 10 protein entries:     KAPCB_HUMAN (see all proteins) (see all similar genes):
    KIN27    PRKACA    PRKACG    PRKX    PRKY    RPS6KA2
    STK32A    RPS6KA1    RPS6KA5    PDPK2    AKT1    PDPK1
    PRKCB    PRKG2    AKT3    RPS6KA3    RPS6KA4    PRKCH

    PRKACB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2860 SNPs in PRKACB are shown (see all 2860)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588013211,2
    C--82793556(+) CACAGA/TGGGAA 8 -- int10--------
    rs715829171,2
    C--84544793(+) ATCATAATCAT/-
            
    GAAAA
    2 -- cds11Minor allele frequency- -:0.50NA 2
    rs1507280531,2
    --84560401(+) TATTAG/TTTTTT 2 -- us2k10--------
    rs1177392031,2
    C,F--84560541(+) AATTAT/GGCACA 2 -- us2k11Minor allele frequency- G:0.05EA 120
    rs120590741,2
    C,H--84560754(+) ACAACA/GCAGAA 2 -- us2k13Minor allele frequency- G:0.04EA NS WA 270
    rs1924222701,2
    --84560920(+) TATGCA/GTCTAT 2 -- us2k10--------
    rs57757761,2
    C--84560930(+) TTTTT-/T/TT  
            
    GCGCT
    2 -- int1 trp31NA 2
    rs1401692291,2
    --84560981(+) ATCCAA/CAAGTT 2 -- us2k10--------
    rs350003191,2
    C,F,H--84561032(+) AATTGC/ACAGGG 2 -- us2k118Minor allele frequency- A:0.08NS EA NA 2220
    rs1135957941,2
    F--84561045(+) CAAATC/GCTGCT 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for PRKACB (84543745 - 84704181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for PRKACB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1732CNV Loss18451855
    nsv871656CNV Loss21882294
    nsv871731CNV Loss21882294
    nsv871655CNV Loss21882294
    nsv871375CNV Loss21882294
    dgv263n71CNV Loss21882294
    nsv830414CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176892    OMIM disorders: --

    12 diseases for PRKACB:    About MalaCards
    primary pigmented nodular adrenocortical disease    prion disease    neurologic diseases    hiv type 1
    cholera    dilated cardiomyopathy    colorectal cancer    prostate cancer
    prostatitis    endotheliitis    breast cancer    neuronitis


    PRKACB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKACB
    Human Genome Epidemiology (HuGE) Navigator: PRKACB (2 documents)

    Export disorders for PRKACB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKACB gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with PRKACB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene. (PubMed id 12420224)1, 2 Wu K.-J.... Dalla-Favera R. (2002)
    5. Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. (PubMed id 11589697)1, 2 Orstavik S....Skalhegg B.S. (2001)
    6. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. (PubMed id 2342480)1, 2 Beebe S.J.... Jahnsen T. (1990)
    7. Protein kinases A and C in post-mortem prefrontal cor tex from persons with major depression and normal controls. (PubMed id 19573263)1, 9 Shelton R.C....Lewis D.A. (2009)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5567 HGNC: 9381 AceView: PRKACB Ensembl:ENSG00000142875 euGenes: HUgn5567
    ECgene: PRKACB Kegg: 5567 H-InvDB: PRKACB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKACB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKACB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/prkacb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKACB gene:
    Search GeneIP for patents involving PRKACB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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