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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKACA Gene

protein-coding   GIFtS: 74
GCID: GC19M014202

protein kinase, cAMP-dependent, catalytic, alpha
 Explore 47 diseases affiliated with
PRKACA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRKACA    

Aliases
for PRKACA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Kinase, CAMP-Dependent, Catalytic, Alpha1 2     PKACa1
PKACA2 3     CAMP-Dependent Protein Kinase Catalytic Subunit Alpha2
PKA C-Alpha2 3     Protein Kinase A Catalytic Subunit2
EC 2.7.11.113 8     EC 2.7.118

External Ids:    HGNC: 93801   Entrez Gene: 55662   Ensembl: ENSG000000720627   OMIM: 6016395   UniProtKB: P176123   

Export aliases for PRKACA gene to outside databases

Previous GC identifers: GC19M014557 GC19M014047 GC19M014063 GC19M013774


Summaries
for PRKACA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRKACA:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the
cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The
inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the
dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric
catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of
cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been
observed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of
compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these
subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2,
RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation
increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in
response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in
numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA),
but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet
aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of
alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by
phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store
overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity
of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by
phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent
endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight
junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50
DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines
embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote
spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by
phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT).
Phosphorylates APOBEC3G and AICDA

summary for PRKACA:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACA


Genomic Views
for PRKACA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKACA gene promoter:
         GR   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKACA promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKACA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKACA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

PRKACA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKACA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014202:  view genomic region     (about GC identifiers)

Start:
 14,202,500 bp from pter      End:
 14,228,896 bp from pter
Size:
 26,397 bases      Orientation:
 minus strand

Proteins
for PRKACA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit alpha  
Size: 351 amino acids; 40590 Da
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the
different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive
holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The
cAMP-dependent protein kinase catalytic subunit binds PJA2. Both isoforms 1 and 2 forms activate cAMP-sensitive PKAI
and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively.
Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds
to ABL1 in spermatozoa and with CDC25B in oocytes. Interacts with APOBEC3G and AICDA
Subcellular location: Cytoplasm. Cell membrane. Nucleus (By similarity). Mitochondrion (By similarity).
Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic
competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity)
6/19 PDB 3D structures from and Proteopedia for PRKACA (see all 19):
2GU8 (3D)        3AGL (3D)        3AGM (3D)        3AMA (3D)        3AMB (3D)        3L9L (3D)    
Secondary accessions: Q32P54 Q9H2Y0 Q9NRB4 Q9NRH9
Alternative splicing: 2 isoforms:  P17612-1   P17612-2   

Explore the universe of human proteins at neXtProt for PRKACA: NX_P17612

Post-translational modifications:

  • Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By
    • similarity)1
  • Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues.
    • Phosphorylation on Thr-198 is required for full activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17612

    • 4/20 DME Specific Peptides for PRKACA (P17612) (see all 20)
     EKCGKEF  TDFGFAK  GVNDIKN  LKPENLL 

    PRKACA Protein expression data from MOPED and PaxDb:    About this image 
    PRKACA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002721.1  NP_997401.1  

    ENSEMBL proteins: 
     ENSP00000309591   ENSP00000466976   ENSP00000468352   ENSP00000466651   ENSP00000466289  
     ENSP00000466660   ENSP00000441654  
    Reactome Protein details: P17612
    Human Recombinant Protein Products for PRKACA: 
    EMD Millipore Purified and/or Recombinant PRKACA Protein
    R&D Systems Recombinant & Natural Proteins for PRKACA (PKA C alpha)
    Enzo Life Sciences proteins for PRKACA
    OriGene Purified Proteins (see all 2): PRKACA
    OriGene Protein Over-expression Lysate (see all 2): PRKACA
    OriGene Custom Protein Services for PRKACA 
    GenScript Custom Purified and Recombinant Proteins Services for PRKACA
    Novus Biologicals PRKACA Proteins
    Novus Biologicals PRKACA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRKACA
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    PRKACA for ontologies           About GeneDecksing



    PRKACA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKACA
    R&D Systems Antibodies for PRKACA (PKA C alpha/beta, PKA C alpha)
    Cell Signaling Technology (CST) Antibodies for PRKACA  (PKACa)
    OriGene Antibodies (see all 2): PRKACA
    OriGene Custom Antibody Services for PRKACA 
    GenScript Custom Superior Antibodies Services for PRKACA
    Novus Biologicals PRKACA Antibodies
    Abcam antibodies for PRKACA 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for PRKACA

    Assay Products for PRKACA: 
    EMD Millipore Kits and Assays for the Analysis of PRKACA
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript PRKACA-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PRKACA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRKACA for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P17612

    ProtoNet protein and cluster: P17612

    1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Function
    for PRKACA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAPCA_HUMAN, P17612
    Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of
    compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these
    subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2,
    RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation
    increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in
    response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in
    numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA),
    but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet
    aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of
    alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by
    phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store
    overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity
    of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by
    phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent
    endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight
    junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50
    DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines
    embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote
    spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by
    phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT).
    Phosphorylates APOBEC3G and AICDA
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide acts
    as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics
    synchronously and priming it for catalysis. Inhibited by H89
    (N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide), spiroindoline, azole-based inhibitors,
    (3s)-amino-aminomethylbenzamide analogs, ARC-1032
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-4-carbamimidamido-1-carbamoylbutyl]hexanamide),
    ARC-1034
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]hexanamide),
    ARC-582, ARC-902 (Adc-6-aminohexanoic acid-(D-Arg)(6)-NH(2)), ARC-1012
    ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}hexanamido)-N-(5-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]carbamoyl}pentyl)hexanamide)
    and ARC-1039
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-1-[(5-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]carbamoyl}pentyl)carbamoyl]ethyl]he
    xanamide)

         Genatlas biochemistry entry for PRKACA:
    protein kinase,cAMP-dependent,catalytic,alpha subunit

         Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity NAS2843813
    GO:0005515protein binding IPI15630084
    GO:0005524ATP binding NAS--
    GO:0019901protein kinase binding IPI11035810
         
    PRKACA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRKACA:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i  Stronger migration 

         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Prkaca):
     adipose tissue  cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  mortality/aging  nervous system  renal/urinary system  reproductive system 
     skeleton  tumorigenesis 

    PRKACA for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for PRKACA: Prkacatm2Gsm Prkacatm1Gsm
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRKACA 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): PRKACA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKACA
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKACA (see all 28):
    hsa-miR-607 hsa-miR-4307 hsa-miR-3660 hsa-miR-1260b hsa-miR-486-3p hsa-miR-650 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: PRKACA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKACA (see all 7)
    OriGene shRNA RFP: PRKACA
    OriGene siRNA: PRKACA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKACA
    Sirion Biotech Custom design and validation of potent shRNA sequences against PRKACA 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRKACA
    Sirion Biotech Customized adenovirus for overexpression of PRKACA 
    Sirion Biotech Customized adenovirus for potent knockdown of PRKACA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACA (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKACA (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKACA (NM_002730)
    Sino Biological Human cDNA Clone for PRKACA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKACA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACA 

    Cell Line
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    Search LifeMap BioReagents cell lines for PRKACA
    Sirion Biotech Customized stable knockdown cell line services for PRKACA 
    Sirion Biotech Customized inducible knockdown cell line services for PRKACA
    Sirion Biotech Customized stable overexpressing cell line services for PRKACA
    Sirion Biotech Customized inducible overexpressing cell line services for PRKACA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACA


    Pathways & Interactions
    for PRKACA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/121 super-pathways (see all 121) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PKA activation in glucagon signalling
    8/12 pathways (see all 12)
    		PKA activation in glucagon signalling1.00
    		Neurophysiological process_PGE2-induced pain processing0.44
    		PKA activation0.94
    		Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.37
    		PKA-mediated phosphorylation of CREB0.89
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    		Regulation of CFTR gating (normal and CF)0.76
    		Development Role of Activin A in cell differentiation and proliferation0.33
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		Development Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    		Development_Beta-adrenergic receptors regulation of ERK0.55
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/34 EMD Millipore Pathways for PRKACA (see all 34)
        Cell cycle Role of APC in cell cycle regulation
    Development Ligand-independent activation of ESR1 and ESR2
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    G-protein signaling G-Protein beta/gamma signaling cascades
    G-protein signaling G-Protein alpha-s signaling cascades

    5/52 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKACA (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for PRKACA
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/40 GeneGo (Thomson Reuters) Pathways for PRKACA (see all 40)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5/31 BioSystems Pathways for PRKACA (see all 31) 
        G Protein Signaling Pathways
    MAPK signaling pathway
    Calcium Regulation in the Cardiac Cell
    Estrogen signaling pathway
    Myometrial Relaxation and Contraction Pathways

    5/59        Reactome Pathways for PRKACA (see all 59)
        PKA activation
    Recruitment of mitotic centrosome proteins and complexes
    Signaling by EGFR in Cancer
    Downstream signal transduction
    DARPP-32 events

    2 PharmGKB Pathways for PRKACA
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    5/27         Kegg Pathways  (Kegg details for PRKACA) (see all 27):
        MAPK signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Apoptosis


    PRKACA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKACA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/300 Interacting proteins for PRKACA (P176121, 2, 3 ENSP000003095914) via UniProtKB, MINT, STRING, and/or I2D (see all 300)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042062, 3, ENSP000003842734MINT-50025 MINT-50026 MINT-50065 I2D: score=3 STRING: ENSP00000384273
    BCL2L11O435212, 3MINT-8142385 I2D: score=1 
    PDE4DQ084992, 3, ENSP000003848064MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 I2D: score=1 STRING: ENSP00000384806
    RXFP1Q9HBX92, ENSP000003032484MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 STRING: ENSP00000303248
    GRIA4P480582, 3, ENSP000002824994MINT-13729 MINT-49874 I2D: score=2 STRING: ENSP00000282499
    About this table

    Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001707mesoderm formation IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--

    PRKACA for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRKACA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRKACA for compounds           About GeneDecksing

    EMD Millipore small molecules for PRKACA:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PRKACA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    8-Bromo-cAMP, sodium salt Cell-permeable cAMP analog[76939-46-3]
    cAMPS-Rp, triethylammonium salt cAMP antagonist[73208-40-9]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]
    Dibutyryl-cAMP, sodium salt Cell-permeable cAMP analog[16980-89-5]

    3 HMDB Compounds for PRKACA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10/43 DrugBank Compounds for PRKACA (see all 43)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Balanol-- --target--17139284 17016423 10592235
    Balanol Analog 2-- --target--17139284 17016423 10592235
    Balanol Analog 8-- --target--17139284 17016423 10592235
    N-Octane-- 111-65-9target--17139284 17016423 10592235
    Pentanal-- 110-62-3target--17139284 17016423 10592235
    Phosphonoserine-- --target--17139284 17016423 10592235
    Phosphonothreonine-- --target--17139284 17016423 10592235
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423 10592235
    (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE-- --target--10592235
    (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE-- --target--10592235

    6 Novoseek chemical compound relationships for PRKACA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 54.9 2 1714581 (1), 9178752 (1)
    forskolin 49.7 2 1714581 (1), 9389510 (1)
    cyclic amp 36.4 1 1965098 (1)
    dexamethasone 17.4 2 19383776 (1)
    atp 12.1 2 9405483 (2)
    ethanol 0 1 1965098 (1)

    Search CenterWatch for drugs/clinical trials and news about PRKACA / KAPCA 

    Transcripts
    for PRKACA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRKACA gene (2 alternative transcripts): 
    NM_002730.3  NM_207518.1  

    Unigene Cluster for PRKACA:

    Protein kinase, cAMP-dependent, catalytic, alpha
    Hs.631630  [show with all ESTs]
    Unigene Representative Sequence: AK131561
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308677(uc002myc.3) ENST00000350356(uc002myb.3) ENST00000590853
    ENST00000587372 ENST00000589994 ENST00000588209 ENST00000587533 ENST00000536649(uc010xnm.1 uc002myd.3)
    ENST00000593092 ENST00000589284 ENST00000535695

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKACA (see all 28):
    hsa-miR-607 hsa-miR-4307 hsa-miR-3660 hsa-miR-1260b hsa-miR-486-3p hsa-miR-650 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: PRKACA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRKACA (see all 7)
    OriGene shRNA RFP: PRKACA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKACA (NM_002730)
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    Additional cDNA sequence: 

    AF208004.1 AF224718.1 AF239744.1 AK131561.1 AK290147.1 AK292284.1 AK301264.1 BC039846.1 
    BC108259.1 M80335.1 X07767.1 

    13 DOTS entries:

    DT.99955392  DT.418922  DT.100018343  DT.95158689  DT.100788463  DT.92427153  DT.100788461  DT.91865857 
    DT.100788462  DT.80100098  DT.95158683  DT.99973980  DT.434650 

    24/339 AceView cDNA sequences (see all 339):

    AA593221 BM982529 CN482626 AI318392 AW950078 BE676313 BU617989 CB054976 
    BQ181777 CA433696 BU856014 BM796029 BU543594 BU741900 AW950079 BM850259 
    BM714958 BM725154 CA312924 BF343290 BM721554 BQ945222 AF208004 H25036 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKACA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                      -                                   -               
    SP2:        -     -                       -                                   -               
    SP3:                                      -                                                   
    SP4:              -                       -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PRKACA

    Expression
    for PRKACA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKACA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAGTGGGT
    PRKACA Expression
    About this image

    PRKACA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Growth PlatePrehypertrophic ChondrocytesBone, Cartilage
    BoneCervical VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneLumbar VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneSacral VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneStylopod Growth PlatePrehypertrophic ChondrocytesBone, Cartilage
    BoneThoracic RibPrehypertrophic ChondrocytesBone, Cartilage
    BoneThoracic VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneZeugopod Growth PlatePrehypertrophic ChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRKACA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKACA

    SOURCE GeneReport for Unigene cluster: Hs.631630

    UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
    Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is sperm specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKACA: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PRKACA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKACA gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 97(a)
    		 1 → many
    		 GL343212.1(2149026-2156519)
    zebrafish
    (Danio rerio)    		 Actinopterygii prkacaa1 protein kinase, cAMP-dependent, catalytic, alpha, genome more 80.63(n)
    94.02(a)    		   564064  NM_001082840.1  NP_001076309.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pka-C13 anterior/posterior pattern formation,
    imaginal more    		 82(a)
    (best of 4)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea F47F2.1a3
    kin-11    		 protein kinase3
    Protein KIN-11    		 52(a)
    (best of 2)3
    72.68(n)1
    84.62(a)1    		   X(3926462-3928330)3
    35654071  NM_170958.21  NP_740954.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TPK1(YJL164C)4
    TPK11    		 cAMP-dependent protein kinase catalytic subunit; promotes more4
    Tpk1p1    		 52.66(n)1
    49.84(a)1    		   10(111159-109966)4
    8532751, 4  NP_012371.21  NP_012371.14 
    barley
    (Hordeum vulgare)    		 Liliopsida BF626879.22   -- 74.43(n)    BF626879.2 


    ENSEMBL Gene Tree for PRKACA (if available)
    TreeFam Gene Tree for PRKACA (if available) 

    Paralogs
    for PRKACA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKACA gene
    PRKX2  PRKACG2  PRKG22  PRKG12  PRKACB2  
    18/128 SIMAP similar genes for PRKACA using alignment to 4 protein entries:     KAPCA_HUMAN (see all proteins) (see all similar genes):
    KIN27    PRKACB    PRKACG    PRKX    PKN2    PRKY
    RPS6KA2    RPS6KA1    RPS6KA6    SGK2    PRKG1    SGK3
    RPS6KA3    RPS6KA5    PRKG2    RPS6KB2    AKT1    STK32A

    PRKACA for paralogs           About GeneDecksing



    Genomic Variants
    for PRKACA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/401 NCBI SNPs in PRKACA are shown (see all 401)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1850775951,2
    		--14202003(+) CCAGCC/GCGCTC 2 -- ds50010--------
    rs1419182061,2
    		--14202380(+) TAAACC/TCTGGT 2 -- ds50010--------
    rs1891390011,2
    		--14202556(+) CAGCAA/CACTGT 2 -- ut310--------
    rs1810063221,2
    		--14202614(+) GCACCC/TACCCG 2 -- ut310--------
    rs152471,2
    		C,F,H--14202687(-) TTCATC/ACCCGT 2 -- ut316Minor allele frequency- A:0.01MN NS 1130
    rs412963281,2
    		C--14202693(-) ACCCCA/GTTCAT 2 -- ut312Minor allele frequency- G:0.01NS 94
    rs412963261,2
    		C,F--14202734(-) TTTTT-/TCTCTC 2 -- ut312Minor allele frequency- T:0.02NS 88
    rs1845944721,2
    		--14202762(+) TGGGGG/TAGAGG 2 -- ut310--------
    rs1389230291,2
    		--14202973(+) AATCTA/GGCGGA 2 -- ut310--------
    rs1893844961,2
    		--14203002(+) GGGGGA/GAAACG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKACA (14202500 - 14228896 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PRKACA
         2 CNVs: 73315 5089
    Human Gene Mutation Database (HGMD): PRKACA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKACA
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKACA

    Disorders / Diseases
    for PRKACA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRKACA for disorders           About GeneDecksing

    OMIM gene information: 601639    OMIM disorders: --

    20/47 diseases for PRKACA (see all 47):    About MalaCards
    primary pigmented nodular adrenocortical disease    adenomatous polyposis coli    systemic lupus erythematosus    lupus erythematosus
    pituitary tumor    hypertrophic cardiomyopathy    acute lymphoblastic leukemia    lymphoblastic leukemia
    prion disease    wilms tumor    cystic fibrosis    cardiomyopathy
    polyposis    thyroid adenoma    neurologic diseases    hepatitis c
    huntington's disease    colon adenocarcinoma    cholera    adenoma

    1 Novoseek disease relationship for PRKACA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 39.6 1 14703016 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRKACA (18 documents)

    Export disorders for PRKACA gene to outside databases

    Publications
    for PRKACA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKACA gene, integrated from 9 sources (see all 482):
    (articles sorted by number of sources associating them with PRKACA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit. (PubMed id 15642694)1, 2, 9 Guan H....Ricciardi R.P. (2005)
    2. The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA. (PubMed id 21812984)1, 2 Vetter M.M....Skaalhegg B.S. (2011)
    3. Protein kinase A activates and phosphorylates ROR?4 in vitro and takes part in ROR? activation by CaMK-IV. (PubMed id 21514275)1, 2 Ermisch M.... Steinhilber D. (2011)
    4. High glucose stimulates adipogenic and inhibits osteo genic differentiation in MG-63 cells through cAMP/protein kinase A/extracellula r signal-regulated kinase pathway. (PubMed id 19949837)1, 2 Wang W....Yang J. (2010)
    5. Thrombin and collagen induce a feedback inhibitory si gnaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. (PubMed id 20356841)1, 2 Gambaryan S....Walter U. (2010)
    6. Diversity of bisubstrate binding modes of adenosine a nalogue-oligoarginine conjugates in protein kinase a and implications for prote in substrate interactions. (PubMed id 20732331)1, 2 Pflug A....Bossemeyer D. (2010)
    7. Gravin dynamics regulates the subcellular distribution of PKA. (PubMed id 19210988)1, 2 Yan X....Grove B. (2009)
    8. Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells. (PubMed id 17333334)1, 2 Xu H....Manni A. (2008)
    9. Allosteric cooperativity in protein kinase A. (PubMed id 18178622)1, 2 Masterson L.R....Veglia G. (2008)
    10. Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif. (PubMed id 18836454)1, 2 Shirakawa K....Uchiyama T. (2008)

    External Searches for PRKACA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRKACA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5566 HGNC: 9380 AceView: PRKACA Ensembl:ENSG00000072062 euGenes: HUgn5566
    ECgene: PRKACA Kegg: 5566 H-InvDB: PRKACA

    Other Databases showing PRKACA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRKACA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKACA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKACA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/prkaca/

    Intellectual Property
    for PRKACA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRKACA gene:
    Search GeneIP for patents involving PRKACA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRKACA gene

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    About This Section

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     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRKACA
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for PRKACA
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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