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PRKACA Gene

protein-coding   GIFtS: 77
GCID: GC19M014202

Protein Kinase, CAMP-Dependent, Catalytic, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, CAMP-Dependent, Catalytic, Alpha1 2     CAMP-Dependent Protein Kinase Catalytic Subunit Alpha2
PKACA2 3     Protein Kinase A Catalytic Subunit2
PKA C-Alpha2 3     EC 2.7.118
EC 2.7.11.113 8     

External Ids:    HGNC: 93801   Entrez Gene: 55662   Ensembl: ENSG000000720627   OMIM: 6016395   UniProtKB: P176123   

Export aliases for PRKACA gene to outside databases

Previous GC identifers: GC19M014557 GC19M014047 GC19M014063 GC19M013774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKACA Gene:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating
the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target
proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.
cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP
and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have
been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and
is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding
distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKACA Gene:
PRKACA (protein kinase, cAMP-dependent, catalytic, alpha) is a protein-coding gene. Diseases associated with PRKACA include primary pigmented nodular adrenocortical disease, and drug addiction. GO annotations related to this gene include protein kinase A regulatory subunit binding and protein kinase binding. An important paralog of this gene is PRKX.

UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of
compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6,
PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic
differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation
of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by
phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and
NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA
stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative
and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel
activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and
increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+)
release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting
cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight
junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B
p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway
that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested
oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the
pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1
in sperm flagellum to promote spermatozoa capacitation

summary for PRKACA Gene:
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose
metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is
composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the
regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit
releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the
transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific
sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKACA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKACA gene promoter:
         GR   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKACA promoter sequence
   Search Chromatin IP Primers for PRKACA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKACA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

PRKACA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKACA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014202:  view genomic region     (about GC identifiers)

Start:
14,202,500 bp from pter      End:
14,228,896 bp from pter
Size:
26,397 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase catalytic subunit alpha  
Size: 351 amino acids; 40590 Da
Subunit: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of
the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the
inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic
subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Both isoforms 1 and 2 forms activate
cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and
PRKAR2A/PKR2, respectively. Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted
by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes. Interacts with APOBEC3G and
AICDA. Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly
Selected PDB 3D structures from and Proteopedia for PRKACA (see all 19):
2GU8 (3D)        3AGL (3D)        3AGM (3D)        3AMA (3D)        3AMB (3D)        3L9L (3D)    
Secondary accessions: Q32P54 Q9H2Y0 Q9NRB4 Q9NRH9
Alternative splicing: 2 isoforms:  P17612-1   P17612-2   

Explore the universe of human proteins at neXtProt for PRKACA: NX_P17612

Explore proteomics data for PRKACA at MOPED

Post-translational modifications: 

  • Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively
    (By similarity)1
  • Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues.
    Phosphorylation on Thr-198 is required for full activity1
  • Phosphorylated at Tyr-331 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic
    efficienncy (By similarity)1
  • Ubiquitination2 at Lys93
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKACA (P17612) (see all 20)
     EKCGKEF  TDFGFAK  GVNDIKN  LKPENLL 


    See PRKACA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002721.1  NP_997401.1  

    ENSEMBL proteins: 
     ENSP00000309591   ENSP00000466976   ENSP00000468352   ENSP00000466651   ENSP00000466289  
     ENSP00000466660  
    Reactome Protein details: P17612

    PRKACA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKACA Protein
    R&D Systems Recombinant & Natural Proteins for PRKACA (PKA C alpha)
    Enzo Life Sciences proteins for PRKACA
    OriGene Purified Proteins for PRKACA
    OriGene Protein Over-expression Lysate for PRKACA
    OriGene MassSpec for PRKACA
    OriGene Custom Protein Services for PRKACA
    GenScript Custom Purified and Recombinant Proteins Services for PRKACA
    Novus Biologicals PRKACA Proteins
    Novus Biologicals PRKACA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRKACA
    Browse Proteins at Cloud-Clone Corp.

    PRKACA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKACA
    R&D Systems Antibodies for PRKACA (PKA C alpha/beta, PKA C alpha)
    Cell Signaling Technology (CST) Antibodies for PRKACA  (PKACA)
    OriGene Antibodies for PRKACA
    OriGene Custom Antibody Services for PRKACA
    Novus Biologicals PRKACA Antibodies
    Abcam antibodies for PRKACA (P22694, P22612, P17612)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PRKACA
    LSBio Antibodies in human, mouse, rat for PRKACA

    PRKACA Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PRKACA
    OriGene Custom Assay Services for PRKACA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRKACA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, cAMP-dependent, catalytic, alpha subunit
    Protein kinase A
    Protein kinase A (PKA) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P17612

    ProtoNet protein and cluster: P17612

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    PRKACA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAPCA_HUMAN, P17612
    Function: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of
    compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates
    these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6,
    PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic
    differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation
    of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by
    phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and
    NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA
    stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative
    and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel
    activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and
    increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+)
    release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting
    cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight
    junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B
    p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway
    that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested
    oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the
    pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1
    in sperm flagellum to promote spermatozoa capacitation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide
    acts as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics
    synchronously and priming it for catalysis. Inhibited by H89
    (N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide), spiroindoline, azole-based
    inhibitors, (3s)-amino-aminomethylbenzamide analogs, ARC-1032
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-4-carbamimidamido-1-carbamoylbutyl]hexanamide),
    ARC-1034
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]hexanamide),
    ARC-582, ARC-902 (Adc-6-aminohexanoic acid-(D-Arg)(6)-NH(2)), ARC-1012
    ((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}hexanamido)-N-(5-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]carbamoyl}pentyl)hexanamide)
    and ARC-1039
    (6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]formamido}-N-[(1R)-1-[(5-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]carbamoyl}pentyl)carbamoyl]ethyl]he
    xanamide)

         Genatlas biochemistry entry for PRKACA:
    protein kinase,cAMP-dependent,catalytic,alpha subunit

         Enzyme Numbers (IUBMB): EC 2.7.11.111 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004691cAMP-dependent protein kinase activity NAS2843813
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11035810
         
    PRKACA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRKACA:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i  Stronger migration 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prkaca):
     adipose tissue  cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  renal/urinary system  reproductive system 
     skeleton  tumorigenesis 

    PRKACA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRKACA: Prkacatm2Gsm Prkacatm1Gsm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKACA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKACA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKACA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKACA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKACA:
    hsa-mir-365a-3p (MIRT044041), hsa-mir-331-3p (MIRT043455), hsa-mir-744-5p (MIRT037509), hsa-mir-22-3p (MIRT030635), hsa-mir-196b-5p (MIRT042660)

    Block miRNA regulation of human, mouse, rat PRKACA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKACA (see all 28):
    hsa-miR-607 hsa-miR-4307 hsa-miR-3660 hsa-miR-1260b hsa-miR-486-3p hsa-miR-650 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidPRKACA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKACA
    Predesigned siRNA for gene silencing in human, mouse, rat PRKACA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKACA

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKACA (see all 12)
    OriGene ORF clones in mouse, rat for PRKACA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKACA (NM_002730)
    Sino Biological Human cDNA Clone for PRKACA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKACA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKACA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKACA
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKACA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKACA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    KAPCA_HUMAN, P17612: Cytoplasm. Cell membrane. Nucleus (By similarity). Mitochondrion (By similarity).
    Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the
    cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion
    as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes
    (By similarity)
    KAPCA_HUMAN, P17612: Isoform 2: Cell projection, cilium, flagellum. Note=Expressed in the midpiece region of the
    sperm flagellum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    mitochondrion2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    PRKACA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for PRKACA About   (see all 137)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    EGFR interacts with phospholipase C-gamma0.94
    Neurophysiological process PGE2 induced pain processing0.38
    PLC-gamma1 signalling0.94
    Signal transduction Calcium signaling0.35
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Transcription PPAR Pathway0.34
    ErbB2/ErbB3 signaling events0.31
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    4Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKACA (see all 52)
        Nuclear Receptor Activation by Vitamin-A
    14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    CDK5 Pathway

    2 Cell Signaling Technology (CST) Pathways for PRKACA
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for PRKACA (see all 40)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Transcription PPAR Pathway
    G-protein signaling G-Protein alpha-i signaling cascades
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PRKACA (see all 34)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    Hypothetical Network for Drug Addiction
    Estrogen signaling pathway
    G Protein Signaling Pathways


    Selected Reactome Pathways for PRKACA (see all 18)
        PKA activation
    PKA-mediated phosphorylation of key metabolic factors
    Regulation of insulin secretion
    Recruitment of mitotic centrosome proteins and complexes
    PKA activation in glucagon signalling

    2 PharmGKB Pathways for PRKACA
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PRKACA) (see all 50):
        MAPK signaling pathway
    Ras signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    PRKACA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACA: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKACA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKACA (P176121, 2, 3 ENSP000003095914) via UniProtKB, MINT, STRING, and/or I2D (see all 413)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042062, 3, ENSP000003842734MINT-50025 MINT-50026 MINT-50065 I2D: score=3 STRING: ENSP00000384273
    PRKAR1AP106441, 3, ENSP000003514104EBI-476586,EBI-476431 I2D: score=7 STRING: ENSP00000351410
    GSK3BP498411, 3, ENSP000003248064EBI-476586,EBI-373586 I2D: score=2 STRING: ENSP00000324806
    BCL2L11O435212, 3MINT-8142385 I2D: score=1 
    PDE4DQ084992, 3, ENSP000003848064MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 I2D: score=1 STRING: ENSP00000384806
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001707mesoderm formation IEA--
    GO:0002027regulation of heart rate TAS--
    GO:0005975carbohydrate metabolic process TAS--

    PRKACA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKACA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog[71774-13-5]
    H 89 dihydrochlorideProtein kinase A inhibitor[127243-85-0]
    PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor[201422-03-9]
    PKA inhibitor fragment (6-22) amidePotent protein kinase A inhibitor[121932-06-7]
    KT 5720Selective protein kinase A inhibitor[108068-98-0]

    3 HMDB Compounds for PRKACA    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected DrugBank Compounds for PRKACA (see all 44)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Balanol-- --target--17139284 17016423 10592235
    Balanol Analog 2-- --target--17139284 17016423 10592235
    Balanol Analog 8-- --target--17139284 17016423 10592235
    N-Octane-- 111-65-9target--17139284 17016423 10592235
    Pentanal-- 110-62-3target--17139284 17016423 10592235
    Phosphonoserine-- --target--17139284 17016423 10592235
    Phosphonothreonine-- --target--17139284 17016423 10592235
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target--17139284 17016423 10592235
    (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE-- --target--10592235
    (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE-- --target--10592235

    6 Novoseek inferred chemical compound relationships for PRKACA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 54.9 2 1714581 (1), 9178752 (1)
    forskolin 49.7 2 1714581 (1), 9389510 (1)
    cyclic amp 36.4 1 1965098 (1)
    dexamethasone 17.4 2 19383776 (1)
    atp 12.1 2 9405483 (2)
    ethanol 0 1 1965098 (1)



    PRKACA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKACA gene (2 alternative transcripts): 
    NM_002730.3  NM_207518.1  

    Unigene Cluster for PRKACA:

    Protein kinase, cAMP-dependent, catalytic, alpha
    Hs.631630  [show with all ESTs]
    Unigene Representative Sequence: AK131561
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308677(uc002myc.3) ENST00000350356(uc002myb.3) ENST00000590853
    ENST00000587372 ENST00000589994 ENST00000588209 ENST00000587533 ENST00000536649(uc010xnm.1 uc002myd.3)
    ENST00000593092 ENST00000589284
    miRNA
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    hsa-miR-607 hsa-miR-4307 hsa-miR-3660 hsa-miR-1260b hsa-miR-486-3p hsa-miR-650 hsa-miR-3125 hsa-miR-3916
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    Additional mRNA sequence: 

    AF208004.1 AF224718.1 AF239744.1 AK131561.1 AK290147.1 AK292284.1 AK301264.1 BC039846.1 
    BC108259.1 M80335.1 X07767.1 

    13 DOTS entries:

    DT.99955392  DT.418922  DT.100018343  DT.95158689  DT.100788463  DT.92427153  DT.100788461  DT.91865857 
    DT.100788462  DT.80100098  DT.95158683  DT.99973980  DT.434650 

    Selected AceView cDNA sequences (see all 339):

    T89486 AW589371 BX445403 BI964076 BM725154 BQ945449 AI074203 AI693677 
    BM841548 AI419832 CB054976 AI309904 AI318392 AW950079 BQ446333 BQ448176 
    BM850259 AF208004 CA421805 N63031 CR625910 BE382436 AW770267 BQ181777 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRKACA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                      -                                   -               
    SP2:        -     -                       -                                   -               
    SP3:                                      -                                                   
    SP4:              -                       -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PRKACA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKACA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGTGGGT
    PRKACA Expression
    About this image


    PRKACA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PRKACA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKACA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631630

    UniProtKB/Swiss-Prot: KAPCA_HUMAN, P17612
    Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is sperm-specific and is enriched in pachytene
    spermatocytes but is not detected in round spermatids

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKACA: 
              Fatty Acid Metabolism in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKACA gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkaca1 , 5 protein kinase, cAMP dependent, catalytic, alpha1, 5 91.26(n)1
    98.01(a)1
      8 (40.22 cM)5
    187471  NM_008854.51  NP_032880.11 
     839729785 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    30(a)
    many ↔ many
    AADN03024991.1(213-2045)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    2(119457730-119468670)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prkaca1 protein kinase, cAMP-dependent, catalytic, alpha 77.97(n)
    93.45(a)
      549157  NM_001016403.2  NP_001016403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkacab1 protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b less 78.44(n)
    89.46(a)
      445076  NM_001003470.1  NP_001003470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pka-C13 anterior/posterior pattern formation,
    imaginal disc protein serine/threonine
    kinase less
    82(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F47F2.1a3 protein kinase 52(a)
    (best of 2)
      X(3926462-3928330)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPK1(YJL164C)4
    TPK21
    cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p less4
    TPK21
    53.38(n)1
    52.73(a)1
      10(111159-109966)4
    8558981  NP_015121.11  8532754 
     NP_012371.14 
    barley
    (Hordeum vulgare)
    Liliopsida BF626879.22   -- 74.43(n)    BF626879.2 


    ENSEMBL Gene Tree for PRKACA (if available)
    TreeFam Gene Tree for PRKACA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKACA gene
    PRKX2  PRKACG2  PRKG22  PRKG12  PRKACB2  
    Selected SIMAP similar genes for PRKACA using alignment to 4 protein entries:     KAPCA_HUMAN (see all proteins) (see all similar genes):
    KIN27    PRKACB    PRKACG    PRKX    PKN2    PRKY
    RPS6KA2    RPS6KA1    RPS6KA6    SGK2    SGK3    RPS6KA3
    PRKG1    RPS6KA5    PRKG2    AKT1    STK32A    PRKCB

    PRKACA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKACA (see all 518)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850775951,2
    --14202003(+) CCAGCC/GCGCTC 2 -- ds50010--------
    rs1419182061,2
    --14202380(+) TAAACC/TCTGGT 2 -- ds50010--------
    rs1891390011,2
    --14202556(+) CAGCAA/CACTGT 2 -- ut310--------
    rs1810063221,2
    --14202614(+) GCACCC/TACCCG 2 -- ut310--------
    rs152471,2
    C,F,H--14202687(-) TTCATC/ACCCGT 2 -- ut316Minor allele frequency- A:0.01MN NS 1130
    rs412963281,2
    C,F--14202693(-) ACCCCA/GTTCAT 2 -- ut312Minor allele frequency- G:0.01NS 94
    rs412963261,2
    C,F--14202735(-) TTTTT-/TCTCTC 2 -- ut312Minor allele frequency- T:0.02NS 88
    rs1845944721,2
    --14202762(+) TGGGGG/TAGAGG 2 -- ut310--------
    rs1389230291,2
    C--14202973(+) AATCTA/GGCGGA 2 -- ut310--------
    rs1893844961,2
    --14203002(+) GGGGGA/GAAACG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKACA (14202500 - 14228896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRKACA (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677290CNV Deletion23128226
    nsv911119CNV Loss21882294
    nsv833761CNV Loss17160897
    nsv911117CNV Loss21882294
    dgv49n68CNV Loss17160897
    nsv911120CNV Loss21882294
    dgv3741n71CNV Loss21882294
    dgv3744n71CNV Loss21882294
    dgv3739n71CNV Loss21882294
    nsv828452CNV Loss20364138

    Human Gene Mutation Database (HGMD): PRKACA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKACA
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKACA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601639    OMIM disorders: --

    Selected diseases for PRKACA (see all 46):    
    About MalaCards
    primary pigmented nodular adrenocortical disease    drug addiction    prion disease    thyroid adenoma
    pituitary tumors    neurologic diseases    hypertrophic cardiomyopathy    wiskott-aldrich syndrome
    wilms tumor    osteoporosis    pertussis    colon adenocarcinoma
    dilated cardiomyopathy    choriocarcinoma    gingivitis    cholera
    cystic fibrosis    huntington's disease    hepatitis c virus    hiv-1


    PRKACA for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PRKACA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 39.6 1 14703016 (1)

    Genetic Association Database (GAD): PRKACA
    Human Genome Epidemiology (HuGE) Navigator: PRKACA (18 documents)

    Export disorders for PRKACA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKACA gene, integrated from 10 sources (see all 518):
    (articles sorted by number of sources associating them with PRKACA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit. (PubMed id 15642694)1, 2, 9 Guan H.... Ricciardi R.P. (J. Biol. Chem. 2005)
    2. The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA. (PubMed id 21812984)1, 2 Vetter M.M....Skaalhegg B.S. (BMC Biochem. 2011)
    3. Protein kinase A activates and phosphorylates ROR?4 in vitro and takes part in ROR? activation by CaMK-IV. (PubMed id 21514275)1, 2 Ermisch M.... Steinhilber D. (Biochem. Biophys. Res. Commun. 2011)
    4. Diversity of bisubstrate binding modes of adenosine analogue- oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. (PubMed id 20732331)1, 2 Pflug A....Bossemeyer D. (J. Mol. Biol. 2010)
    5. High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway. (PubMed id 19949837)1, 2 Wang W.... Yang J. (Mol. Cell. Biochem. 2010)
    6. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. (PubMed id 20356841)1, 2 Gambaryan S.... Walter U. (J. Biol. Chem. 2010)
    7. Gravin dynamics regulates the subcellular distribution of PKA. (PubMed id 19210988)1, 2 Yan X.... Grove B. (Exp. Cell Res. 2009)
    8. Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha- difluoromethylornithine in breast cancer cells. (PubMed id 17333334)1, 2 Xu H.... Manni A. (Breast Cancer Res. Treat. 2008)
    9. Allosteric cooperativity in protein kinase A. (PubMed id 18178622)1, 2 Masterson L.R.... Veglia G. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif. (PubMed id 18836454)1, 2 Shirakawa K.... Uchiyama T. (Nat. Struct. Mol. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5566 HGNC: 9380 AceView: PRKACA Ensembl:ENSG00000072062 euGenes: HUgn5566
    ECgene: PRKACA Kegg: 5566 H-InvDB: PRKACA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRKACA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKACA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/prkaca/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRKACA gene:
    Search GeneIP for patents involving PRKACA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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